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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:mevalonic acid
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Accession:CHEBI:25351 term browser browse the term
Definition:A racemate composed of equimolar amounts of (R)- and (S)-mevalonic acid.
Synonyms:exact_synonym: rac-3,5-dihydroxy-3-methylpentanoic acid
 related_synonym: (+-)-2,4-dideoxy-3-C-methylpentonic acid;   (+-)-3,5-dihydroxy-3-methylvaleric acid;   (3RS)-mevalonic acid;   DL-Mevalonic acid;   Formula=C6H12O4;   MVA;   RS-Mevalonic acid;   rac-MVA;   rac-mevalonic acid;   racemic mevalonic acid
 xref: Beilstein:1722595;   CAS:150-97-0;   HMDB:HMDB0000227
 xref_mesh: MESH:D008798
 xref: PMID:10369261;   PMID:10647065;   PMID:10947201;   PMID:11521206;   PMID:12031835;   PMID:12872277;   PMID:1653652;   PMID:22770225;   PMID:2702744;   PMID:3012338;   PMID:32004772;   PMID:35840187;   PMID:36247639;   PMID:5683362;   PMID:6236250;   PMID:6263908;   PMID:6565710;   PMID:6610447;   PMID:6953445;   PMID:8747489;   Reaxys:1722595;   Wikipedia:Mevalonic_acid
 cyclic_relationship: is_conjugate_acid_of CHEBI:25350



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mevalonic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP binding cassette subfamily A member 1 multiple interactions ISO Mevalonic Acid inhibits the reaction [mevastatin inhibits the reaction [8-((4-chlorophenyl)thio)cyclic-3',5'-AMP results in increased expression of ABCA1 protein]] CTD PMID:16415093 NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170
JBrowse link
G Acacb acetyl-CoA carboxylase beta multiple interactions EXP Mevalonic Acid inhibits the reaction [Atorvastatin results in increased expression of ACACB mRNA] CTD PMID:12056585 NCBI chr12:42,365,800...42,477,651
Ensembl chr12:42,366,548...42,457,655
JBrowse link
G Acan aggrecan multiple interactions EXP Mevalonic Acid inhibits the reaction [Simvastatin results in increased expression of ACAN mRNA] CTD PMID:18628692 NCBI chr 1:132,981,582...133,044,416
Ensembl chr 1:132,981,582...133,043,627
JBrowse link
G Agt angiotensinogen multiple interactions EXP Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [AGT protein results in increased phosphorylation of PXN protein]] CTD PMID:22306966 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO Mevalonic Acid inhibits the reaction [Asbestos, Crocidolite results in increased activity of AKT1 protein]; Mevalonic Acid inhibits the reaction [Asbestos, Crocidolite results in increased expression of AKT1 mRNA]
Mevalonic Acid inhibits the reaction [Simvastatin results in decreased phosphorylation of AKT1 protein]
CTD PMID:17322126 PMID:33034787 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Bbc3 Bcl-2 binding component 3 multiple interactions ISO Mevalonic Acid inhibits the reaction [Simvastatin results in increased expression of BBC3 protein] CTD PMID:20045437 NCBI chr 1:77,013,281...77,022,509
Ensembl chr 1:77,014,543...77,022,509
JBrowse link
G Bcar1 BCAR1 scaffold protein, Cas family member multiple interactions EXP Mevalonic Acid inhibits the reaction [Lovastatin results in increased cleavage of BCAR1 protein] CTD PMID:16367743 NCBI chr19:39,679,215...39,713,907
Ensembl chr19:39,679,204...39,713,907
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO
EXP
Mevalonic Acid inhibits the reaction [Lovastatin results in decreased expression of BCL2 protein] CTD PMID:11178870 PMID:12094262 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743
JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions EXP Mevalonic Acid inhibits the reaction [Lovastatin results in decreased expression of BCL2L1 protein] CTD PMID:11178870 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
JBrowse link
G Bid BH3 interacting domain death agonist multiple interactions EXP Mevalonic Acid inhibits the reaction [Atorvastatin results in decreased expression of and results in increased cleavage of BID protein] CTD PMID:18339080 NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720
JBrowse link
G Bmp2 bone morphogenetic protein 2 multiple interactions EXP
ISO
Mevalonic Acid inhibits the reaction [Simvastatin results in increased expression of BMP2 mRNA] CTD PMID:10814523 PMID:18628692 NCBI chr 3:120,812,660...120,822,579
Ensembl chr 3:120,812,882...120,821,397
JBrowse link
G Cacna1c calcium voltage-gated channel subunit alpha1 C multiple interactions EXP Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of CACNA1C mRNA]; Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of CACNA1C protein]; Mevalonic Acid inhibits the reaction [Verapamil results in decreased expression of CACNA1C mRNA]; Mevalonic Acid inhibits the reaction [Verapamil results in decreased expression of CACNA1C protein] CTD PMID:19791473 NCBI chr 4:151,764,138...152,379,454
Ensembl chr 4:151,764,138...152,379,648
JBrowse link
G Cacna1h calcium voltage-gated channel subunit alpha1 H multiple interactions EXP Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of CACNA1H mRNA]; Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of CACNA1H protein]; Mevalonic Acid inhibits the reaction [Verapamil results in decreased expression of CACNA1H mRNA]; Mevalonic Acid inhibits the reaction [Verapamil results in decreased expression of CACNA1H protein] CTD PMID:19791473 NCBI chr10:14,390,104...14,448,204
Ensembl chr10:14,390,113...14,448,376
JBrowse link
G Casp3 caspase 3 multiple interactions ISO
EXP
Mevalonic Acid inhibits the reaction [Atorvastatin results in increased activity of CASP3 protein]; Mevalonic Acid inhibits the reaction [cerivastatin results in increased activity of CASP3 protein]; Mevalonic Acid inhibits the reaction [Fluvastatin results in increased cleavage of and results in increased activity of CASP3 protein]; Mevalonic Acid inhibits the reaction [Simvastatin results in increased activity of CASP3 protein]; Mevalonic Acid inhibits the reaction [Simvastatin results in increased expression of CASP3 protein]
Mevalonic Acid inhibits the reaction [Atorvastatin results in increased activity of CASP3 protein]; Mevalonic Acid inhibits the reaction [Lovastatin results in increased activity of and results in increased cleavage of CASP3 protein]; Mevalonic Acid inhibits the reaction [Simvastatin results in increased activity of CASP3 protein]
CTD PMID:15949312 PMID:16367743 PMID:16470222 PMID:16698853 PMID:17428261 More... NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp7 caspase 7 multiple interactions ISO Mevalonic Acid inhibits the reaction [Simvastatin results in increased activity of CASP7 protein]; Mevalonic Acid inhibits the reaction [Simvastatin results in increased cleavage of CASP7 protein] CTD PMID:20045437 PMID:20427495 NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729
JBrowse link
G Casp8 caspase 8 multiple interactions ISO Mevalonic Acid inhibits the reaction [Fluvastatin results in increased activity of CASP8 protein] CTD PMID:24964743 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Casp9 caspase 9 multiple interactions ISO
EXP
Mevalonic Acid inhibits the reaction [Simvastatin results in increased cleavage of CASP9 protein]
Mevalonic Acid inhibits the reaction [Atorvastatin results in increased activity of CASP9 protein]
CTD PMID:18339080 PMID:20045437 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO Mevalonic Acid inhibits the reaction [Atorvastatin inhibits the reaction [TNF results in increased expression of CCL2 mRNA]]; Mevalonic Acid inhibits the reaction [Atorvastatin results in decreased expression of CCL2 mRNA]; Mevalonic Acid inhibits the reaction [cerivastatin inhibits the reaction [TNF results in increased expression of CCL2 mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of CCL2 mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased expression of CCL2 mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of CCL2 mRNA] CTD PMID:12117737 PMID:16321392 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Ccl3 C-C motif chemokine ligand 3 multiple interactions ISO Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of CCL3 mRNA]] CTD PMID:16321392 NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938
JBrowse link
G Ccl4 C-C motif chemokine ligand 4 multiple interactions ISO Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of CCL4 mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased expression of CCL4 mRNA]] CTD PMID:16321392 NCBI chr10:68,466,394...68,468,229
Ensembl chr10:68,452,052...68,468,231
JBrowse link
G Ccna2 cyclin A2 multiple interactions EXP Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of CCNA2 protein] CTD PMID:26577051 NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577
JBrowse link
G Ccne1 cyclin E1 multiple interactions EXP Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of CCNE1 protein] CTD PMID:26577051 NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101
JBrowse link
G Ccr1 C-C motif chemokine receptor 1 multiple interactions ISO Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of CCR1 mRNA]] CTD PMID:16321392 NCBI chr 8:123,556,286...123,561,841 JBrowse link
G Ccr2 C-C motif chemokine receptor 2 multiple interactions ISO Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of CCR2 mRNA]] CTD PMID:16321392 NCBI chr 8:123,734,465...123,742,483
Ensembl chr 8:123,734,430...123,742,100
JBrowse link
G Ccr4 C-C motif chemokine receptor 4 multiple interactions ISO Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased expression of CCR4 mRNA]] CTD PMID:16321392 NCBI chr 8:114,176,291...114,182,033
Ensembl chr 8:114,176,974...114,178,056
JBrowse link
G Ccr5 C-C motif chemokine receptor 5 multiple interactions ISO Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of CCR5 mRNA]] CTD PMID:16321392 NCBI chr 8:123,752,423...123,757,538
Ensembl chr 8:123,752,325...123,759,260
JBrowse link
G Cd40 CD40 molecule multiple interactions ISO Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of CD40 mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of CD40 protein]] CTD PMID:17507688 NCBI chr 3:153,790,372...153,805,279
Ensembl chr 3:153,790,449...153,805,534
JBrowse link
G Cd40lg CD40 ligand multiple interactions ISO Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [CD40LG results in increased expression of VCAM1 mRNA]] CTD PMID:18269829 NCBI chr  X:135,127,052...135,138,768
Ensembl chr  X:135,126,969...135,138,306
JBrowse link
G Cd44 CD44 molecule multiple interactions ISO Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of CD44 protein] CTD PMID:21199873 NCBI chr 3:89,155,850...89,244,615
Ensembl chr 3:89,157,058...89,244,620
JBrowse link
G Cdk1 cyclin-dependent kinase 1 multiple interactions EXP Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of CDK1 protein] CTD PMID:26577051 NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408
JBrowse link
G Cdk2 cyclin dependent kinase 2 multiple interactions EXP Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of CDK2 protein] CTD PMID:26577051 NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403
JBrowse link
G Cenpf centromere protein F multiple interactions ISO Mevalonic Acid inhibits the reaction [Lovastatin results in increased expression of CENPF protein]; Mevalonic Acid inhibits the reaction [Paclitaxel results in increased expression of CENPF protein] CTD PMID:12467231 NCBI chr13:101,184,127...101,229,714
Ensembl chr13:101,184,127...101,229,669
JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex decreases phosphorylation
multiple interactions
ISO Mevalonic Acid results in decreased phosphorylation of CHUK protein
Mevalonic Acid inhibits the reaction [Asbestos, Crocidolite results in increased activity of and results in increased phosphorylation of CHUK protein]
CTD PMID:17322126 NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:242,959,760...242,995,065
JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions ISO Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of COL1A1 mRNA] CTD PMID:16575855 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
JBrowse link
G Col2a1 collagen type II alpha 1 chain multiple interactions EXP Mevalonic Acid inhibits the reaction [Simvastatin results in increased expression of COL2A1 mRNA] CTD PMID:18628692 NCBI chr 7:129,098,489...129,127,560
Ensembl chr 7:129,098,786...129,127,546
JBrowse link
G Crp C-reactive protein multiple interactions ISO Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [CRP results in increased expression of RETN mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [CRP results in increased secretion of RETN protein]] CTD PMID:18023360 NCBI chr13:85,135,384...85,175,178
Ensembl chr13:85,124,977...85,175,178
JBrowse link
G Ctf1 cardiotrophin 1 multiple interactions EXP Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [CTF1 results in increased expression of JAK1 protein]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [CTF1 results in increased expression of JAK2 protein]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [CTF1 results in increased expression of NPPA mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [CTF1 results in increased expression of STAT1 protein]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [CTF1 results in increased expression of STAT3 protein]] CTD PMID:16534557 NCBI chr 1:182,328,035...182,336,346
Ensembl chr 1:182,328,090...182,333,335
JBrowse link
G Ddb2 damage specific DNA binding protein 2 multiple interactions ISO Mevalonic Acid inhibits the reaction [Fluvastatin results in decreased expression of DDB2 mRNA]; Mevalonic Acid inhibits the reaction [Fluvastatin results in decreased expression of DDB2 protein] CTD PMID:24964743 NCBI chr 3:77,185,114...77,207,650
Ensembl chr 3:77,185,109...77,207,631
JBrowse link
G Dgat1 diacylglycerol O-acyltransferase 1 multiple interactions EXP Mevalonic Acid inhibits the reaction [Atorvastatin results in increased activity of DGAT1 protein] CTD PMID:12056585 NCBI chr 7:108,223,860...108,235,413
Ensembl chr 7:108,218,524...108,234,299
JBrowse link
G Edn1 endothelin 1 multiple interactions ISO Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of EDN1 mRNA]; Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of EDN1 protein] CTD PMID:18390205 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
JBrowse link
G Egfr epidermal growth factor receptor multiple interactions EXP Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [Acrolein results in increased phosphorylation of EGFR protein]] CTD PMID:20359552 NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382
JBrowse link
G F3 coagulation factor III, tissue factor multiple interactions ISO Mevalonic Acid inhibits the reaction [Fluvastatin results in decreased expression of F3 mRNA]; Mevalonic Acid inhibits the reaction [Fluvastatin results in decreased expression of F3 protein]; Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of F3] CTD PMID:9081680 PMID:12753293 NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668
JBrowse link
G Fasn fatty acid synthase multiple interactions EXP Mevalonic Acid inhibits the reaction [Atorvastatin results in increased expression of FASN mRNA] CTD PMID:12056585 NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261
JBrowse link
G Fbxo32 F-box protein 32 multiple interactions ISO Mevalonic Acid inhibits the reaction [Lovastatin results in increased expression of FBXO32 mRNA]; Mevalonic Acid inhibits the reaction [Lovastatin results in increased expression of FBXO32 protein] CTD PMID:19406843 NCBI chr 7:89,731,428...89,764,997
Ensembl chr 7:89,730,232...89,765,436
JBrowse link
G Foxo1 forkhead box O1 multiple interactions ISO Mevalonic Acid inhibits the reaction [Simvastatin results in decreased phosphorylation of and affects the localization of FOXO1 protein] CTD PMID:33034787 NCBI chr 2:136,312,168...136,390,603
Ensembl chr 2:136,312,168...136,387,790
JBrowse link
G Foxp3 forkhead box P3 multiple interactions ISO Mevalonic Acid inhibits the reaction [Simvastatin results in increased expression of FOXP3] CTD PMID:20408897 NCBI chr  X:14,908,494...14,924,994
Ensembl chr  X:14,908,494...14,923,838
JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase decreases activity
multiple interactions
ISO
EXP
Mevalonic Acid results in decreased activity of HMGCR protein
[25-hydroxycholesterol co-treated with Mevalonic Acid] results in increased ubiquitination of HMGCR protein
Mevalonic Acid inhibits the reaction [Atorvastatin results in increased activity of HMGCR protein]; Mevalonic Acid inhibits the reaction [Atorvastatin results in increased expression of HMGCR mRNA]; Mevalonic Acid inhibits the reaction [Clofibrate results in decreased expression of HMGCR mRNA]; Mevalonic Acid inhibits the reaction [Simvastatin results in increased activity of HMGCR protein]; Mevalonic Acid inhibits the reaction [Simvastatin results in increased expression of HMGCR mRNA]
CTD PMID:12056585 PMID:12477733 PMID:12518023 PMID:21944868 NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased expression of ICAM1 mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin promotes the reaction [IL1B protein results in increased expression of ICAM1 protein]] CTD PMID:10946302 PMID:20863785 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
JBrowse link
G Ifng interferon gamma multiple interactions ISO Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of CCL2 mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of CCL3 mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of CCL4 mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of CCR1 mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of CCR2 mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of CCR5 mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of HLA-DRA protein]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of TNFRSF4 mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of TNFRSF4 protein]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of TNFSF4 mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of TNFSF4 protein]]
Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of CD40 mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of CD40 protein]]
CTD PMID:11219190 PMID:16321392 PMID:17507688 PMID:19589242 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Il12b interleukin 12B multiple interactions ISO Mevalonic Acid inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL12B protein] CTD PMID:15187114 NCBI chr10:28,888,832...28,903,802
Ensembl chr10:28,893,008...28,902,903
JBrowse link
G Il17a interleukin 17A multiple interactions ISO Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of IL17A mRNA] CTD PMID:18453621 NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889
JBrowse link
G Il18 interleukin 18 multiple interactions EXP Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [Aldosterone results in increased expression of IL18 mRNA]] CTD PMID:18660453 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
JBrowse link
G Il1a interleukin 1 alpha multiple interactions ISO
EXP
Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [[IL1A co-treated with PDGFB] results in increased secretion of MMP9 protein]]
Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IL1A results in decreased expression of NOS2 protein]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IL1A results in increased abundance of Nitric Oxide]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IL1A results in increased localization of RELA protein]]
CTD PMID:15705589 PMID:15728660 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased secretion of IL1B protein]]; Mevalonic Acid inhibits the reaction [Simvastatin promotes the reaction [IL1B protein results in increased expression of ICAM1 protein]]; Mevalonic Acid inhibits the reaction [Simvastatin promotes the reaction [IL1B protein results in increased expression of SELE protein]] CTD PMID:10946302 PMID:17075836 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 multiple interactions ISO Mevalonic Acid inhibits the reaction [Atorvastatin inhibits the reaction [TNF results in increased expression of IL6 mRNA]]; Mevalonic Acid inhibits the reaction [Atorvastatin results in decreased expression of IL6 mRNA]; Mevalonic Acid inhibits the reaction [cerivastatin inhibits the reaction [TNF results in increased expression of IL6 mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IL6 results in increased expression of VEGFA mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IL6 results in increased expression of VEGFA protein]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased expression of IL6 mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased secretion of IL6 protein]]; Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of IL6 mRNA]
Mevalonic Acid inhibits the reaction [Simvastatin promotes the reaction [[Lipopolysaccharides co-treated with TNF] results in increased expression of IL6 protein]]
CTD PMID:12117737 PMID:16424782 PMID:16511915 PMID:17075836 PMID:17729120 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Irf4 interferon regulatory factor 4 multiple interactions ISO Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of IRF4 mRNA]; Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of IRF4 protein] CTD PMID:33034787 NCBI chr17:33,721,800...33,742,570
Ensembl chr17:33,721,811...33,740,070
JBrowse link
G Itga2 integrin subunit alpha 2 multiple interactions EXP
ISO
Mevalonic Acid inhibits the reaction [Atorvastatin results in increased expression of [ITGA2 protein binds to ITGB1 protein]]; Mevalonic Acid inhibits the reaction [Pravastatin results in increased expression of [ITGA2 protein binds to ITGB1 protein]] CTD PMID:12500026 NCBI chr 2:46,520,345...46,621,487
Ensembl chr 2:46,523,948...46,621,481
JBrowse link
G Itgb1 integrin subunit beta 1 multiple interactions EXP
ISO
Mevalonic Acid inhibits the reaction [Atorvastatin results in increased expression of [ITGA2 protein binds to ITGB1 protein]]; Mevalonic Acid inhibits the reaction [Pravastatin results in increased expression of [ITGA2 protein binds to ITGB1 protein]]
Mevalonic Acid inhibits the reaction [Atorvastatin results in increased expression of [ITGA2 protein binds to ITGB1 protein]]; Mevalonic Acid inhibits the reaction [Atorvastatin results in increased expression of ITGB1 mRNA]; Mevalonic Acid inhibits the reaction [Pravastatin results in increased expression of [ITGA2 protein binds to ITGB1 protein]]
CTD PMID:12500026 NCBI chr19:56,705,123...56,753,199
Ensembl chr19:56,705,171...56,753,195
JBrowse link
G Jak1 Janus kinase 1 multiple interactions EXP Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [CTF1 results in increased expression of JAK1 protein]] CTD PMID:16534557 NCBI chr 5:115,780,248...115,888,841
Ensembl chr 5:115,780,248...115,888,926
JBrowse link
G Jak2 Janus kinase 2 multiple interactions EXP Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [CTF1 results in increased expression of JAK2 protein]] CTD PMID:16534557 NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189
JBrowse link
G Klf2 KLF transcription factor 2 multiple interactions ISO Mevalonic Acid inhibits the reaction [Simvastatin results in increased expression of KLF2 mRNA] CTD PMID:20493886 NCBI chr16:17,521,107...17,523,739
Ensembl chr16:17,514,552...17,523,944
JBrowse link
G Lep leptin multiple interactions ISO Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of LEP mRNA]; Mevalonic Acid inhibits the reaction [Simvastatin results in decreased secretion of LEP protein] CTD PMID:19254925 NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO
EXP
Mevalonic Acid inhibits the reaction [Atorvastatin results in decreased phosphorylation of MAPK1 protein]
Mevalonic Acid inhibits the reaction [Atorvastatin results in increased phosphorylation of MAPK1 protein]; Mevalonic Acid inhibits the reaction [Lovastatin results in decreased phosphorylation of MAPK1 protein]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [Acrolein results in increased phosphorylation of MAPK1 protein]]
CTD PMID:16470222 PMID:16952276 PMID:18339080 PMID:20359552 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions EXP
ISO
Mevalonic Acid inhibits the reaction [Atorvastatin results in increased phosphorylation of MAPK3 protein]; Mevalonic Acid inhibits the reaction [Lovastatin results in decreased phosphorylation of MAPK3 protein]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [Acrolein results in increased phosphorylation of MAPK3 protein]]
Mevalonic Acid inhibits the reaction [Atorvastatin results in decreased phosphorylation of MAPK3 protein]
CTD PMID:16470222 PMID:16952276 PMID:18339080 PMID:20359552 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mmp1 matrix metallopeptidase 1 multiple interactions ISO Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [Lipopolysaccharides results in increased secretion of MMP1 protein]]; Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of MMP1 mRNA]; Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of MMP1 protein]; Mevalonic Acid inhibits the reaction [Simvastatin results in decreased secretion of MMP1 protein] CTD PMID:17303772 PMID:18625914 NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [[IL1A co-treated with PDGFB] results in increased secretion of MMP9 protein]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of MMP9 protein]] CTD PMID:15728660 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Mstn myostatin multiple interactions ISO Mevalonic Acid inhibits the reaction [Simvastatin results in increased expression of MSTN mRNA]; Mevalonic Acid inhibits the reaction [Simvastatin results in increased expression of MSTN protein] CTD PMID:33034787 NCBI chr 9:48,452,533...48,458,933
Ensembl chr 9:48,452,533...48,458,933
JBrowse link
G Mttp microsomal triglyceride transfer protein multiple interactions EXP Mevalonic Acid inhibits the reaction [Atorvastatin results in increased expression of MTTP mRNA] CTD PMID:12056585 NCBI chr 2:226,613,090...226,654,239
Ensembl chr 2:226,613,090...226,654,239
JBrowse link
G Muc5ac mucin 5AC, oligomeric mucus/gel-forming multiple interactions ISO Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [Acrolein results in increased expression of MUC5AC protein]] CTD PMID:20359552 NCBI chr 1:196,864,336...196,896,475
Ensembl chr 1:196,864,336...196,896,475
JBrowse link
G Mvk mevalonate kinase multiple interactions
increases phosphorylation
ISO 3,3-dimethylallyl pyrophosphate inhibits the reaction [MVK protein results in increased phosphorylation of Mevalonic Acid]; dolichol monophosphate inhibits the reaction [MVK protein results in increased phosphorylation of Mevalonic Acid]; Farnesol inhibits the reaction [MVK protein results in increased phosphorylation of Mevalonic Acid]; farnesyl pyrophosphate inhibits the reaction [MVK protein results in increased phosphorylation of Mevalonic Acid]; geranyl diphosphate inhibits the reaction [MVK protein results in increased phosphorylation of Mevalonic Acid]; geranylgeranyl pyrophosphate inhibits the reaction [MVK protein results in increased phosphorylation of Mevalonic Acid]; isopentenyl pyrophosphate inhibits the reaction [MVK protein results in increased phosphorylation of Mevalonic Acid] CTD PMID:9392419 NCBI chr12:42,141,391...42,158,893
Ensembl chr12:42,141,384...42,158,882
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions EXP Mevalonic Acid affects the reaction [Simvastatin results in increased localization of NFE2L2 protein] CTD PMID:18787804 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO Mevalonic Acid inhibits the reaction [Asbestos, Crocidolite affects the localization of NFKB1 protein]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]] CTD PMID:17277159 PMID:17322126 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO Mevalonic Acid inhibits the reaction [Asbestos, Crocidolite results in decreased expression of and results in increased phosphorylation of NFKBIA protein]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased degradation of NFKBIA protein]] CTD PMID:17075836 PMID:17322126 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP
ISO
Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IL1A results in decreased expression of NOS2 protein]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [TNF results in decreased expression of NOS2 protein]]
Mevalonic Acid inhibits the reaction [Simvastatin promotes the reaction [[Lipopolysaccharides co-treated with TNF] results in increased expression of NOS2 mRNA]]
Mevalonic Acid inhibits the reaction [Fluvastatin results in increased expression of NOS2 protein]
CTD PMID:15705589 PMID:17729120 PMID:24964743 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions ISO Mevalonic Acid inhibits the reaction [Simvastatin results in increased expression of NOS3 mRNA]; Mevalonic Acid inhibits the reaction [Y 27632 results in increased phosphorylation of NOS3 protein] CTD PMID:17322126 PMID:20493886 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
JBrowse link
G Nppa natriuretic peptide A multiple interactions EXP Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [CTF1 results in increased expression of NPPA mRNA]] CTD PMID:16534557 NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351
JBrowse link
G Nr4a3 nuclear receptor subfamily 4, group A, member 3 multiple interactions ISO Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of NR4A3 mRNA] CTD PMID:16005304 NCBI chr 5:62,361,588...62,401,489
Ensembl chr 5:62,361,822...62,402,733
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO Mevalonic Acid inhibits the reaction [Simvastatin promotes the reaction [TNFSF10 protein results in increased cleavage of PARP1 protein]]; Mevalonic Acid inhibits the reaction [Simvastatin results in increased cleavage of PARP1 protein]; Mevalonic Acid inhibits the reaction [TNFSF10 protein promotes the reaction [Simvastatin results in increased cleavage of PARP1 protein]] CTD PMID:20045437 PMID:21910007 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions ISO Mevalonic Acid inhibits the reaction [Asbestos, Crocidolite results in increased expression of PCNA protein]; Mevalonic Acid inhibits the reaction [Clostridium difficile lethal toxin B results in increased expression of PCNA protein]; Mevalonic Acid inhibits the reaction [Y 27632 results in increased expression of PCNA protein] CTD PMID:17322126 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
JBrowse link
G Pcyt1a phosphate cytidylyltransferase 1A, choline increases activity
increases expression
EXP Mevalonic Acid results in increased activity of PCYT1A protein
Mevalonic Acid results in increased expression of PCYT1A mRNA
CTD PMID:12056585 NCBI chr11:68,313,860...68,357,828
Ensembl chr11:68,313,882...68,357,357
JBrowse link
G Pdgfb platelet derived growth factor subunit B multiple interactions ISO Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [[IL1A co-treated with PDGFB] results in increased secretion of MMP9 protein]]; Mevalonic Acid inhibits the reaction [Simvastatin results in decreased activity of PDGFB protein] CTD PMID:8231022 PMID:15728660 NCBI chr 7:111,539,444...111,557,984
Ensembl chr 7:111,540,345...111,557,984
JBrowse link
G Pdk4 pyruvate dehydrogenase kinase 4 multiple interactions EXP Mevalonic Acid inhibits the reaction [Atorvastatin inhibits the reaction [TNF protein results in decreased expression of PDK4 protein]] CTD PMID:22343369 NCBI chr 4:33,591,796...33,601,798
Ensembl chr 4:33,589,799...33,601,850
JBrowse link
G Plat plasminogen activator, tissue type multiple interactions EXP
ISO
Mevalonic Acid inhibits the reaction [Lovastatin results in increased expression of PLAT protein]
Mevalonic Acid inhibits the reaction [Simvastatin results in increased expression of PLAT mRNA]; Mevalonic Acid inhibits the reaction [Simvastatin results in increased expression of PLAT]
CTD PMID:10412747 PMID:12371961 PMID:12753293 NCBI chr16:69,240,582...69,265,177
Ensembl chr16:69,240,585...69,268,223
JBrowse link
G Pon1 paraoxonase 1 multiple interactions ISO Mevalonic Acid inhibits the reaction [pitavastatin results in increased expression of PON1 mRNA]; Mevalonic Acid inhibits the reaction [Simvastatin promotes the reaction [SREBF2 protein binds to PON1 promoter]]; Mevalonic Acid inhibits the reaction [Simvastatin results in increased expression of PON1 mRNA] CTD PMID:14500290 PMID:15690306 NCBI chr 4:33,294,737...33,325,759
Ensembl chr 4:33,294,722...33,321,360
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions ISO Mevalonic Acid inhibits the reaction [cerivastatin promotes the reaction [Bezafibrate results in increased activity of [PPARA protein binds to RXRA protein]]] CTD PMID:11779144 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions EXP Mevalonic Acid inhibits the reaction [Lovastatin results in increased expression of PPARG mRNA] CTD PMID:20578043 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
JBrowse link
G Prkcd protein kinase C, delta multiple interactions EXP Mevalonic Acid inhibits the reaction [Lovastatin results in increased cleavage of PRKCD protein] CTD PMID:16367743 NCBI chr16:5,769,217...5,799,380
Ensembl chr16:5,769,215...5,799,352
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO Mevalonic Acid affects the reaction [Lovastatin analog results in increased expression of PTGS2 protein]; Mevalonic Acid inhibits the reaction [Simvastatin promotes the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA]] CTD PMID:18612546 PMID:26863638 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Pxn paxillin multiple interactions EXP Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [AGT protein results in increased phosphorylation of PXN protein]] CTD PMID:22306966 NCBI chr12:41,060,791...41,107,952
Ensembl chr12:41,060,791...41,107,931
JBrowse link
G Rac1 Rac family small GTPase 1 multiple interactions ISO
EXP
Mevalonic Acid inhibits the reaction [Lovastatin affects the localization of RAC1 protein]
Mevalonic Acid inhibits the reaction [Simvastatin results in increased expression of RAC1 protein]
CTD PMID:12933658 PMID:16698853 NCBI chr12:11,037,028...11,057,251
Ensembl chr12:11,036,698...11,057,251
JBrowse link
G Rap1a RAP1A, member of RAS oncogene family multiple interactions ISO Mevalonic Acid affects the reaction [Menthol analog results in increased expression of RAP1A protein]; Mevalonic Acid affects the reaction [Menthol results in increased expression of RAP1A protein]; Mevalonic Acid affects the reaction [myrtenol results in increased expression of RAP1A protein]; Mevalonic Acid affects the reaction [perillaldehyde results in increased expression of RAP1A protein]; Mevalonic Acid affects the reaction [perillyl alcohol results in increased expression of RAP1A protein]; Mevalonic Acid inhibits the reaction [cerivastatin results in decreased geranoylation of RAP1A protein]; Mevalonic Acid inhibits the reaction [Simvastatin results in decreased geranoylation of RAP1A protein] CTD PMID:12671036 PMID:25578243 NCBI chr 2:193,208,631...193,286,513
Ensembl chr 2:193,208,635...193,286,501
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP
ISO
Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IL1A results in increased localization of RELA protein]]
Mevalonic Acid inhibits the reaction [Asbestos, Crocidolite affects the localization of RELA protein]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]]
CTD PMID:15705589 PMID:17277159 PMID:17322126 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Retn resistin multiple interactions ISO Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [CRP results in increased expression of RETN mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [CRP results in increased secretion of RETN protein]] CTD PMID:18023360 NCBI chr12:1,710,881...1,712,621
Ensembl chr12:1,710,881...1,712,620
JBrowse link
G Rhoa ras homolog family member A multiple interactions ISO
EXP
Mevalonic Acid affects the reaction [2-methyl-5-(1-methylethenyl)cyclohexanol results in increased expression of RHOA protein]; Mevalonic Acid affects the reaction [carvone results in increased expression of RHOA protein]; Mevalonic Acid affects the reaction [Menthol analog results in increased expression of RHOA protein]; Mevalonic Acid affects the reaction [myrtenol results in increased expression of RHOA protein]; Mevalonic Acid affects the reaction [perillaldehyde results in increased expression of RHOA protein]; Mevalonic Acid affects the reaction [perillic acid results in increased expression of RHOA protein]; Mevalonic Acid affects the reaction [perillyl alcohol results in increased expression of RHOA protein]; Mevalonic Acid inhibits the reaction [Asbestos, Crocidolite results in decreased activity of and results in decreased lipidation of RHOA protein]; Mevalonic Acid inhibits the reaction [Atorvastatin results in decreased activity of RHOA protein]; Mevalonic Acid inhibits the reaction [Atorvastatin results in increased localization of RHOA protein]; Mevalonic Acid inhibits the reaction [Lovastatin affects the localization of RHOA protein]; Mevalonic Acid inhibits the reaction [mevastatin results in decreased lipidation of RHOA protein]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased activity of RHOA protein]]; Mevalonic Acid inhibits the reaction [Simvastatin results in decreased activity of RHOA protein]; Mevalonic Acid inhibits the reaction [Simvastatin results in decreased geranoylation of and affects the localization of RHOA protein]; Mevalonic Acid inhibits the reaction [Simvastatin results in increased localization of RHOA protein]
Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of RHOA protein]
CTD PMID:12477733 PMID:12671036 PMID:12933658 PMID:16005304 PMID:16470222 More... NCBI chr 8:108,991,926...109,025,746
Ensembl chr 8:108,991,954...109,025,746
JBrowse link
G Rhob ras homolog family member B multiple interactions ISO Mevalonic Acid affects the reaction [2-methyl-5-(1-methylethenyl)cyclohexanol results in increased expression of RHOB protein]; Mevalonic Acid affects the reaction [carveol results in increased expression of RHOB protein]; Mevalonic Acid affects the reaction [carvone results in increased expression of RHOB protein]; Mevalonic Acid affects the reaction [Menthol analog results in increased expression of RHOB protein]; Mevalonic Acid affects the reaction [Menthol results in increased expression of RHOB protein]; Mevalonic Acid affects the reaction [myrtenol results in increased expression of RHOB protein]; Mevalonic Acid affects the reaction [perillaldehyde results in increased expression of RHOB protein]; Mevalonic Acid affects the reaction [perillic acid results in increased expression of RHOB protein]; Mevalonic Acid affects the reaction [perillyl alcohol results in increased expression of RHOB protein] CTD PMID:12671036 NCBI chr 6:31,363,752...31,365,926
Ensembl chr 6:31,363,548...31,366,108
JBrowse link
G Rorc RAR-related orphan receptor C multiple interactions ISO Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of RORC mRNA] CTD PMID:18453621 NCBI chr 2:182,009,707...182,034,910
Ensembl chr 2:182,009,286...182,034,907
JBrowse link
G RT1-Da RT1 class II, locus Da multiple interactions ISO Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of HLA-DRA protein]] CTD PMID:11219190 NCBI chr20:4,513,464...4,518,457
Ensembl chr20:4,512,911...4,518,455
JBrowse link
G Rxra retinoid X receptor alpha multiple interactions ISO Mevalonic Acid inhibits the reaction [cerivastatin promotes the reaction [Bezafibrate results in increased activity of [PPARA protein binds to RXRA protein]]] CTD PMID:11779144 NCBI chr 3:10,989,832...11,076,366
Ensembl chr 3:10,989,832...11,073,712
JBrowse link
G Sele selectin E multiple interactions ISO Mevalonic Acid inhibits the reaction [Simvastatin promotes the reaction [IL1B protein results in increased expression of SELE protein]] CTD PMID:10946302 NCBI chr13:76,402,841...76,412,741
Ensembl chr13:76,403,304...76,412,741
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions ISO Mevalonic Acid inhibits the reaction [Fluvastatin results in increased expression of SOD2 protein] CTD PMID:24964743 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
JBrowse link
G Srebf2 sterol regulatory element binding transcription factor 2 multiple interactions EXP
ISO
Mevalonic Acid inhibits the reaction [Atorvastatin results in increased expression of SREBF2 mRNA]; Mevalonic Acid inhibits the reaction [Simvastatin results in increased expression of SREBF2 mRNA]
Mevalonic Acid inhibits the reaction [Simvastatin promotes the reaction [SREBF2 protein binds to PON1 promoter]]
CTD PMID:12056585 PMID:14500290 NCBI chr 7:113,663,202...113,720,850
Ensembl chr 7:113,663,202...113,720,848
JBrowse link
G Stat1 signal transducer and activator of transcription 1 multiple interactions
increases expression
ISO
EXP
Mevalonic Acid inhibits the reaction [Simvastatin results in decreased phosphorylation of STAT1 protein]
Mevalonic Acid results in increased expression of STAT1 protein
Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [CTF1 results in increased expression of STAT1 protein]]
Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of STAT1 mRNA]; Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of STAT1 protein]
CTD PMID:16534557 PMID:17507688 PMID:18453621 NCBI chr 9:49,419,561...49,459,969
Ensembl chr 9:49,419,340...49,588,540
JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions EXP
ISO
Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [CTF1 results in increased expression of STAT3 protein]]
Mevalonic Acid inhibits the reaction [Simvastatin results in decreased phosphorylation of STAT3 protein]
CTD PMID:16534557 PMID:18453621 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
JBrowse link
G Tfrc transferrin receptor multiple interactions ISO Mevalonic Acid inhibits the reaction [Fluvastatin results in decreased expression of TFRC mRNA]; Mevalonic Acid inhibits the reaction [Fluvastatin results in decreased expression of TFRC protein] CTD PMID:24964743 NCBI chr11:68,163,413...68,185,257
Ensembl chr11:68,163,413...68,185,257
JBrowse link
G Th tyrosine hydroxylase multiple interactions ISO Mevalonic Acid inhibits the reaction [Lovastatin results in increased expression of TH protein] CTD PMID:20694854 NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767
JBrowse link
G Thbd thrombomodulin multiple interactions ISO Mevalonic Acid inhibits the reaction [Simvastatin results in increased expression of THBD mRNA] CTD PMID:20493886 NCBI chr 3:135,863,366...135,867,018
Ensembl chr 3:135,862,835...135,867,193
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP
Mevalonic Acid inhibits the reaction [Atorvastatin inhibits the reaction [TNF results in increased expression of CCL2 mRNA]]; Mevalonic Acid inhibits the reaction [Atorvastatin inhibits the reaction [TNF results in increased expression of CXCL8 mRNA]]; Mevalonic Acid inhibits the reaction [Atorvastatin inhibits the reaction [TNF results in increased expression of IL6 mRNA]]; Mevalonic Acid inhibits the reaction [cerivastatin inhibits the reaction [TNF results in increased expression of CCL2 mRNA]]; Mevalonic Acid inhibits the reaction [cerivastatin inhibits the reaction [TNF results in increased expression of CXCL8 mRNA]]; Mevalonic Acid inhibits the reaction [cerivastatin inhibits the reaction [TNF results in increased expression of IL6 mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased activity of RHOA protein]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased degradation of NFKBIA protein]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased expression of CCL2 mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased expression of CCL4 mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased expression of CCR4 mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased expression of CXCL8 mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased expression of ICAM1 mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased expression of IL6 mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased expression of VCAM1 mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased secretion of IL1B protein]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased secretion of IL6 protein]]
Mevalonic Acid inhibits the reaction [Atorvastatin inhibits the reaction [TNF protein results in decreased expression of PDK4 protein]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [Acrolein results in increased secretion of TNF protein]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [TNF results in decreased expression of NOS2 protein]]
Mevalonic Acid inhibits the reaction [Simvastatin promotes the reaction [[Lipopolysaccharides co-treated with TNF] results in increased abundance of Nitric Oxide]]; Mevalonic Acid inhibits the reaction [Simvastatin promotes the reaction [[Lipopolysaccharides co-treated with TNF] results in increased expression of IL6 protein]]; Mevalonic Acid inhibits the reaction [Simvastatin promotes the reaction [[Lipopolysaccharides co-treated with TNF] results in increased expression of NOS2 mRNA]]
CTD PMID:12117737 PMID:15705589 PMID:16321392 PMID:16511915 PMID:17075836 More... NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tnfrsf4 TNF receptor superfamily member 4 multiple interactions ISO Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of TNFRSF4 mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of TNFRSF4 protein]] CTD PMID:19589242 NCBI chr 5:166,606,909...166,609,599
Ensembl chr 5:166,606,909...166,609,599
JBrowse link
G Tnfsf10 TNF superfamily member 10 multiple interactions ISO Mevalonic Acid inhibits the reaction [Simvastatin promotes the reaction [TNFSF10 protein results in increased cleavage of PARP1 protein]]; Mevalonic Acid inhibits the reaction [TNFSF10 protein promotes the reaction [Simvastatin results in increased cleavage of PARP1 protein]] CTD PMID:21910007 NCBI chr 2:110,199,835...110,227,239
Ensembl chr 2:110,207,916...110,225,135
JBrowse link
G Tnfsf4 TNF superfamily member 4 multiple interactions ISO Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of TNFSF4 mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of TNFSF4 protein]] CTD PMID:19589242 NCBI chr13:73,723,329...73,746,809
Ensembl chr13:73,723,329...73,746,788
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [CD40LG results in increased expression of VCAM1 mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased expression of VCAM1 mRNA]] CTD PMID:18269829 PMID:20863785 NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IL6 results in increased expression of VEGFA mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IL6 results in increased expression of VEGFA protein]]; Mevalonic Acid inhibits the reaction [Simvastatin results in increased expression of VEGFA mRNA] CTD PMID:16424782 PMID:18356691 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link
mevalonolactone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase decreases activity ISO mevalonolactone results in decreased activity of HMGCR protein CTD PMID:3042028 PMID:12477733 NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703
JBrowse link
G Ptgir prostaglandin I2 receptor affects binding ISO mevalonolactone binds to PTGIR protein CTD PMID:11895442 NCBI chr 1:77,579,596...77,581,979
Ensembl chr 1:77,579,596...77,581,979
JBrowse link
G Rap2a RAP2A, member of RAS oncogene family increases farnesylation ISO mevalonolactone results in increased farnesylation of RAP2A protein CTD PMID:8424780 NCBI chr15:97,596,848...97,597,338
Ensembl chr15:97,596,020...97,624,138
JBrowse link
G Rap2b RAP2B, member of RAS oncogene family increases prenylation ISO mevalonolactone results in increased prenylation of RAP2B protein CTD PMID:8424780 NCBI chr 2:145,599,714...145,600,265
Ensembl chr 2:145,599,116...145,603,069
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19918
    chemical entity 19916
      chemical substance 14422
        mixture 13739
          racemate 12113
            mevalonic acid 115
              mevalonolactone 4
              mevalonyl-CoA 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19918
    subatomic particle 19916
      composite particle 19916
        hadron 19916
          baryon 19916
            nucleon 19916
              atomic nucleus 19916
                atom 19916
                  main group element atom 19866
                    p-block element atom 19866
                      carbon group element atom 19811
                        carbon atom 19806
                          organic molecular entity 19806
                            organic group 18995
                              organic divalent group 18969
                                organodiyl group 18969
                                  carbonyl group 18922
                                    carbonyl compound 18922
                                      carboxylic acid 18646
                                        monocarboxylic acid 17984
                                          fatty acid 16709
                                            saturated fatty acid 16409
                                              straight-chain saturated fatty acid 15904
                                                valeric acid 14547
                                                  3,5-dihydroxy-3-methylpentanoic acid 115
                                                    (R)-mevalonic acid 115
                                                      mevalonic acid 115
                                                        mevalonolactone 4
                                                        mevalonyl-CoA 0
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