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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:mevalonic acid
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Accession:CHEBI:25351 term browser browse the term
Definition:A dihydroxy monocarboxylic acid comprising valeric acid having two hydroxy groups at the 3- and 5-positions together with a methyl group at the 3-position.
Synonyms:related_synonym: 3,5-Dihydroxy-3-methylpentanoic acid;   DL-Mevalonic acid;   Formula=C6H12O4;   InChI=1S/C6H12O4/c1-6(10,2-3-7)4-5(8)9/h7,10H,2-4H2,1H3,(H,8,9);   InChIKey=KJTLQQUUPVSXIM-UHFFFAOYSA-N;   MVA;   RS-Mevalonic acid;   SMILES=CC(O)(CCO)CC(O)=O
 xref: Beilstein:1722595;   HMDB:HMDB0000227;   PMID:22770225;   Reaxys:1722595
 cyclic_relationship: is_conjugate_acid_of CHEBI:25350


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(R)-mevalonic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP binding cassette subfamily A member 1 multiple interactions ISO Mevalonic Acid inhibits the reaction [mevastatin inhibits the reaction [8-((4-chlorophenyl)thio)cyclic-3',5'-AMP results in increased expression of ABCA1 protein]] CTD PMID:16415093 NCBI chr 5:69,857,717...69,983,042
Ensembl chr 5:69,857,771...69,983,015
JBrowse link
G Acacb acetyl-CoA carboxylase beta multiple interactions EXP Mevalonic Acid inhibits the reaction [Atorvastatin results in increased expression of ACACB mRNA] CTD PMID:12056585 NCBI chr12:48,127,149...48,238,969
Ensembl chr12:48,127,149...48,238,887
JBrowse link
G Acan aggrecan multiple interactions EXP Mevalonic Acid inhibits the reaction [Simvastatin results in increased expression of ACAN mRNA] CTD PMID:18628692 NCBI chr 1:140,762,758...140,824,441
Ensembl chr 1:140,762,758...140,824,441
JBrowse link
G Agt angiotensinogen multiple interactions EXP Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [AGT protein results in increased phosphorylation of PXN protein]] CTD PMID:22306966 NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO Mevalonic Acid inhibits the reaction [Asbestos, Crocidolite results in increased activity of AKT1 protein]; Mevalonic Acid inhibits the reaction [Asbestos, Crocidolite results in increased expression of AKT1 mRNA] CTD PMID:17322126 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Bbc3 Bcl-2 binding component 3 multiple interactions ISO Mevalonic Acid inhibits the reaction [Simvastatin results in increased expression of BBC3 protein] CTD PMID:20045437 NCBI chr 1:78,261,491...78,267,802 JBrowse link
G Bcar1 BCAR1 scaffold protein, Cas family member multiple interactions EXP Mevalonic Acid inhibits the reaction [Lovastatin results in increased cleavage of BCAR1 protein] CTD PMID:16367743 NCBI chr19:43,932,543...43,967,452
Ensembl chr19:43,932,554...43,955,783
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO
EXP
Mevalonic Acid inhibits the reaction [Lovastatin results in decreased expression of BCL2 protein] CTD PMID:11178870, PMID:12094262 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions EXP Mevalonic Acid inhibits the reaction [Lovastatin results in decreased expression of BCL2L1 protein] CTD PMID:11178870 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Bid BH3 interacting domain death agonist multiple interactions EXP Mevalonic Acid inhibits the reaction [Atorvastatin results in decreased expression of and results in increased cleavage of BID protein] CTD PMID:18339080 NCBI chr 4:153,439,812...153,465,247
Ensembl chr 4:153,442,218...153,465,203
JBrowse link
G Bmp2 bone morphogenetic protein 2 multiple interactions ISO
EXP
Mevalonic Acid inhibits the reaction [Simvastatin results in increased expression of BMP2 mRNA] CTD PMID:10814523, PMID:18628692 NCBI chr 3:126,335,963...126,346,771
Ensembl chr 3:126,335,863...126,346,318
JBrowse link
G Cacna1c calcium voltage-gated channel subunit alpha1 C multiple interactions EXP Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of CACNA1C mRNA]; Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of CACNA1C protein]; Mevalonic Acid inhibits the reaction [Verapamil results in decreased expression of CACNA1C mRNA]; Mevalonic Acid inhibits the reaction [Verapamil results in decreased expression of CACNA1C protein] CTD PMID:19791473 NCBI chr 4:150,635,808...151,270,790
Ensembl chr 4:150,641,066...150,829,913
JBrowse link
G Cacna1h calcium voltage-gated channel subunit alpha1 H multiple interactions EXP Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of CACNA1H mRNA]; Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of CACNA1H protein]; Mevalonic Acid inhibits the reaction [Verapamil results in decreased expression of CACNA1H mRNA]; Mevalonic Acid inhibits the reaction [Verapamil results in decreased expression of CACNA1H protein] CTD PMID:19791473 NCBI chr10:14,730,932...14,789,201
Ensembl chr10:14,730,941...14,788,617
JBrowse link
G Casp3 caspase 3 multiple interactions ISO
EXP
Mevalonic Acid inhibits the reaction [Atorvastatin results in increased activity of CASP3 protein]; Mevalonic Acid inhibits the reaction [cerivastatin results in increased activity of CASP3 protein]; Mevalonic Acid inhibits the reaction [Fluvastatin results in increased cleavage of and results in increased activity of CASP3 protein]; Mevalonic Acid inhibits the reaction [Simvastatin results in increased activity of CASP3 protein]; Mevalonic Acid inhibits the reaction [Simvastatin results in increased expression of CASP3 protein]
Mevalonic Acid inhibits the reaction [Atorvastatin results in increased activity of CASP3 protein]; Mevalonic Acid inhibits the reaction [Lovastatin results in increased activity of and results in increased cleavage of CASP3 protein]; Mevalonic Acid inhibits the reaction [Simvastatin results in increased activity of CASP3 protein]
CTD PMID:15949312, PMID:16367743, PMID:16470222, PMID:16698853, PMID:17428261, PMID:18339080, PMID:20427495, PMID:24964743 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp7 caspase 7 multiple interactions ISO Mevalonic Acid inhibits the reaction [Simvastatin results in increased activity of CASP7 protein]; Mevalonic Acid inhibits the reaction [Simvastatin results in increased cleavage of CASP7 protein] CTD PMID:20045437, PMID:20427495 NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774
JBrowse link
G Casp8 caspase 8 multiple interactions ISO Mevalonic Acid inhibits the reaction [fluvastatin results in increased activity of CASP8 protein] CTD PMID:24964743 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Casp9 caspase 9 multiple interactions ISO
EXP
Mevalonic Acid inhibits the reaction [Simvastatin results in increased cleavage of CASP9 protein]
Mevalonic Acid inhibits the reaction [Atorvastatin results in increased activity of CASP9 protein]
CTD PMID:18339080, PMID:20045437 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO Mevalonic Acid inhibits the reaction [Atorvastatin inhibits the reaction [TNF results in increased expression of CCL2 mRNA]]; Mevalonic Acid inhibits the reaction [Atorvastatin results in decreased expression of CCL2 mRNA]; Mevalonic Acid inhibits the reaction [cerivastatin inhibits the reaction [TNF results in increased expression of CCL2 mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of CCL2 mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased expression of CCL2 mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of CCL2 mRNA] CTD PMID:12117737, PMID:16321392 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccl3 C-C motif chemokine ligand 3 multiple interactions ISO Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of CCL3 mRNA]] CTD PMID:16321392 NCBI chr10:70,869,516...70,871,066
Ensembl chr10:70,869,513...70,871,066
JBrowse link
G Ccl4 C-C motif chemokine ligand 4 multiple interactions ISO Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of CCL4 mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased expression of CCL4 mRNA]] CTD PMID:16321392 NCBI chr10:70,870,926...70,886,357
Ensembl chr10:70,884,531...70,886,355
JBrowse link
G Ccna2 cyclin A2 multiple interactions EXP Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of CCNA2 protein] CTD PMID:26577051 NCBI chr 2:123,274,727...123,282,266
Ensembl chr 2:123,275,881...123,282,214
JBrowse link
G Ccne1 cyclin E1 multiple interactions EXP Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of CCNE1 protein] CTD PMID:26577051 NCBI chr 1:94,485,830...94,495,112
Ensembl chr 1:94,485,832...94,494,980
JBrowse link
G Ccr1 C-C motif chemokine receptor 1 multiple interactions ISO Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of CCR1 mRNA]] CTD PMID:16321392 NCBI chr 8:132,996,646...133,002,201
Ensembl chr 8:132,996,649...133,002,201
JBrowse link
G Ccr2 C-C motif chemokine receptor 2 multiple interactions ISO Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of CCR2 mRNA]] CTD PMID:16321392
G Ccr4 C-C motif chemokine receptor 4 multiple interactions ISO Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased expression of CCR4 mRNA]] CTD PMID:16321392 NCBI chr 8:122,530,152...122,535,959
Ensembl chr 8:122,530,624...122,532,070
JBrowse link
G Ccr5 C-C motif chemokine receptor 5 multiple interactions ISO Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of CCR5 mRNA]] CTD PMID:16321392 NCBI chr 8:133,192,398...133,215,599
Ensembl chr 8:133,197,032...133,215,614
JBrowse link
G Cd40 CD40 molecule multiple interactions ISO Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of CD40 mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of CD40 protein]] CTD PMID:17507688 NCBI chr 3:161,519,789...161,534,943
Ensembl chr 3:161,519,743...161,534,704
JBrowse link
G Cd40lg CD40 ligand multiple interactions ISO Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [CD40LG results in increased expression of VCAM1 mRNA]] CTD PMID:18269829 NCBI chr  X:159,703,703...159,714,886
Ensembl chr  X:159,703,578...159,716,562
JBrowse link
G Cd44 CD44 molecule (Indian blood group) multiple interactions ISO Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of CD44 protein] CTD PMID:21199873 NCBI chr 3:92,695,083...92,783,820
Ensembl chr 3:92,696,313...92,783,658
JBrowse link
G Cdk1 cyclin-dependent kinase 1 multiple interactions EXP Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of CDK1 protein] CTD PMID:26577051 NCBI chr20:20,576,341...20,591,510
Ensembl chr20:20,576,377...20,591,549
JBrowse link
G Cdk2 cyclin dependent kinase 2 multiple interactions EXP Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of CDK2 protein] CTD PMID:26577051 NCBI chr 7:3,124,953...3,132,533
Ensembl chr 7:3,124,954...3,132,457
JBrowse link
G Cenpf centromere protein F multiple interactions ISO Mevalonic Acid inhibits the reaction [Lovastatin results in increased expression of CENPF protein]; Mevalonic Acid inhibits the reaction [Paclitaxel results in increased expression of CENPF protein] CTD PMID:12467231 NCBI chr13:108,132,499...108,178,609
Ensembl chr13:108,132,499...108,178,609
JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex multiple interactions
decreases phosphorylation
ISO Mevalonic Acid inhibits the reaction [Asbestos, Crocidolite results in increased activity of and results in increased phosphorylation of CHUK protein]
Mevalonic Acid results in decreased phosphorylation of CHUK protein
CTD PMID:17322126 NCBI chr 1:263,848,829...263,884,354
Ensembl chr 1:263,848,884...263,885,169
JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions ISO Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of COL1A1 mRNA] CTD PMID:16575855 NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789
JBrowse link
G Col2a1 collagen type II alpha 1 chain multiple interactions EXP Mevalonic Acid inhibits the reaction [Simvastatin results in increased expression of COL2A1 mRNA] CTD PMID:18628692 NCBI chr 7:139,454,945...139,484,403
Ensembl chr 7:139,455,242...139,483,997
JBrowse link
G Crp C-reactive protein multiple interactions ISO Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [CRP results in increased expression of RETN mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [CRP results in increased secretion of RETN protein]] CTD PMID:18023360 NCBI chr13:91,080,448...91,081,358
Ensembl chr13:91,054,974...91,093,713
JBrowse link
G Ctf1 cardiotrophin 1 multiple interactions EXP Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [CTF1 results in increased expression of JAK1 protein]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [CTF1 results in increased expression of JAK2 protein]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [CTF1 results in increased expression of NPPA mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [CTF1 results in increased expression of STAT1 protein]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [CTF1 results in increased expression of STAT3 protein]] CTD PMID:16534557 NCBI chr 1:199,162,319...199,168,296
Ensembl chr 1:199,163,086...199,168,296
JBrowse link
G Ddb2 damage specific DNA binding protein 2 multiple interactions ISO Mevalonic Acid inhibits the reaction [fluvastatin results in decreased expression of DDB2 mRNA]; Mevalonic Acid inhibits the reaction [fluvastatin results in decreased expression of DDB2 protein] CTD PMID:24964743 NCBI chr 3:80,030,437...80,052,984
Ensembl chr 3:80,030,437...80,052,953
JBrowse link
G Dgat1 diacylglycerol O-acyltransferase 1 multiple interactions EXP Mevalonic Acid inhibits the reaction [Atorvastatin results in increased activity of DGAT1 protein] CTD PMID:12056585 NCBI chr 7:117,566,363...117,576,735
Ensembl chr 7:117,566,368...117,576,737
JBrowse link
G Edn1 endothelin 1 multiple interactions ISO Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of EDN1 mRNA]; Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of EDN1 protein] CTD PMID:18390205 NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324
JBrowse link
G Egfr epidermal growth factor receptor multiple interactions EXP Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [Acrolein results in increased phosphorylation of EGFR protein]] CTD PMID:20359552 NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796
JBrowse link
G F3 coagulation factor III, tissue factor multiple interactions ISO Mevalonic Acid inhibits the reaction [Fluvastatin results in decreased expression of F3 mRNA]; Mevalonic Acid inhibits the reaction [Fluvastatin results in decreased expression of F3 protein]; Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of F3] CTD PMID:9081680, PMID:12753293 NCBI chr 2:225,310,686...225,322,281
Ensembl chr 2:225,310,624...225,322,272
JBrowse link
G Fasn fatty acid synthase multiple interactions EXP Mevalonic Acid inhibits the reaction [Atorvastatin results in increased expression of FASN mRNA] CTD PMID:12056585 NCBI chr10:109,987,735...110,005,901
Ensembl chr10:109,987,735...110,005,901
JBrowse link
G Fbxo32 F-box protein 32 multiple interactions ISO Mevalonic Acid inhibits the reaction [Lovastatin results in increased expression of FBXO32 mRNA]; Mevalonic Acid inhibits the reaction [Lovastatin results in increased expression of FBXO32 protein] CTD PMID:19406843 NCBI chr 7:98,065,664...98,098,071
Ensembl chr 7:98,063,735...98,098,268
JBrowse link
G Foxp3 forkhead box P3 multiple interactions ISO Mevalonic Acid inhibits the reaction [Simvastatin results in increased expression of FOXP3] CTD PMID:20408897 NCBI chr  X:15,753,175...15,768,648
Ensembl chr  X:15,753,175...15,768,522
JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase multiple interactions
decreases activity
EXP
ISO
Mevalonic Acid inhibits the reaction [Atorvastatin results in increased activity of HMGCR protein]; Mevalonic Acid inhibits the reaction [Atorvastatin results in increased expression of HMGCR mRNA]; Mevalonic Acid inhibits the reaction [Clofibrate results in decreased expression of HMGCR mRNA]; Mevalonic Acid inhibits the reaction [Simvastatin results in increased activity of HMGCR protein]; Mevalonic Acid inhibits the reaction [Simvastatin results in increased expression of HMGCR mRNA]
Mevalonic Acid results in decreased activity of HMGCR protein
[25-hydroxycholesterol co-treated with Mevalonic Acid] results in increased ubiquitination of HMGCR protein
CTD PMID:12056585, PMID:12477733, PMID:12518023, PMID:21944868 NCBI chr 2:27,480,224...27,500,654
Ensembl chr 2:27,480,226...27,500,654
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased expression of ICAM1 mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin promotes the reaction [IL1B protein results in increased expression of ICAM1 protein]] CTD PMID:10946302, PMID:20863785 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Ifng interferon gamma multiple interactions ISO Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of CCL2 mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of CCL3 mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of CCL4 mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of CCR1 mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of CCR2 mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of CCR5 mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of HLA-DRA protein]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of TNFRSF4 mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of TNFRSF4 protein]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of TNFSF4 mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of TNFSF4 protein]]
Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of CD40 mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of CD40 protein]]
CTD PMID:11219190, PMID:16321392, PMID:17507688, PMID:19589242 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Il12b interleukin 12B multiple interactions ISO Mevalonic Acid inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL12B protein] CTD PMID:15187114 NCBI chr10:30,034,447...30,048,774
Ensembl chr10:30,038,709...30,048,085
JBrowse link
G Il17a interleukin 17A multiple interactions ISO Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of IL17A mRNA] CTD PMID:18453621 NCBI chr 9:26,841,299...26,844,786
Ensembl chr 9:26,841,299...26,844,786
JBrowse link
G Il18 interleukin 18 multiple interactions EXP Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [Aldosterone results in increased expression of IL18 mRNA]] CTD PMID:18660453 NCBI chr 8:55,009,666...55,016,286
Ensembl chr 8:54,993,859...55,016,299
JBrowse link
G Il1a interleukin 1 alpha multiple interactions ISO
EXP
Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [[IL1A co-treated with PDGFB] results in increased secretion of MMP9 protein]]
Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IL1A results in decreased expression of NOS2 protein]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IL1A results in increased abundance of Nitric Oxide]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IL1A results in increased localization of RELA protein]]
CTD PMID:15705589, PMID:15728660 NCBI chr 3:121,824,712...121,836,122
Ensembl chr 3:121,825,412...121,836,086
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased secretion of IL1B protein]]; Mevalonic Acid inhibits the reaction [Simvastatin promotes the reaction [IL1B protein results in increased expression of ICAM1 protein]]; Mevalonic Acid inhibits the reaction [Simvastatin promotes the reaction [IL1B protein results in increased expression of SELE protein]] CTD PMID:10946302, PMID:17075836 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 multiple interactions ISO Mevalonic Acid inhibits the reaction [Atorvastatin inhibits the reaction [TNF results in increased expression of IL6 mRNA]]; Mevalonic Acid inhibits the reaction [Atorvastatin results in decreased expression of IL6 mRNA]; Mevalonic Acid inhibits the reaction [cerivastatin inhibits the reaction [TNF results in increased expression of IL6 mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IL6 results in increased expression of VEGFA mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IL6 results in increased expression of VEGFA protein]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased expression of IL6 mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased secretion of IL6 protein]]; Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of IL6 mRNA]
Mevalonic Acid inhibits the reaction [Simvastatin promotes the reaction [[Lipopolysaccharides co-treated with TNF] results in increased expression of IL6 protein]]
CTD PMID:12117737, PMID:16424782, PMID:16511915, PMID:17075836, PMID:17729120 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Itga2 integrin subunit alpha 2 multiple interactions ISO
EXP
Mevalonic Acid inhibits the reaction [Atorvastatin results in increased expression of [ITGA2 protein binds to ITGB1 protein]]; Mevalonic Acid inhibits the reaction [Pravastatin results in increased expression of [ITGA2 protein binds to ITGB1 protein]] CTD PMID:12500026 NCBI chr 2:46,996,904...47,097,011
Ensembl chr 2:47,000,323...47,096,961
JBrowse link
G Itgb1 integrin subunit beta 1 multiple interactions ISO
EXP
Mevalonic Acid inhibits the reaction [Atorvastatin results in increased expression of [ITGA2 protein binds to ITGB1 protein]]; Mevalonic Acid inhibits the reaction [Atorvastatin results in increased expression of ITGB1 mRNA]; Mevalonic Acid inhibits the reaction [Pravastatin results in increased expression of [ITGA2 protein binds to ITGB1 protein]]
Mevalonic Acid inhibits the reaction [Atorvastatin results in increased expression of [ITGA2 protein binds to ITGB1 protein]]; Mevalonic Acid inhibits the reaction [Pravastatin results in increased expression of [ITGA2 protein binds to ITGB1 protein]]
CTD PMID:12500026 NCBI chr19:61,677,512...61,725,537
Ensembl chr19:61,677,542...61,725,535
JBrowse link
G Jak1 Janus kinase 1 multiple interactions EXP Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [CTF1 results in increased expression of JAK1 protein]] CTD PMID:16534557 NCBI chr 5:119,982,503...120,091,452
Ensembl chr 5:119,982,943...120,083,904
JBrowse link
G Jak2 Janus kinase 2 multiple interactions EXP Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [CTF1 results in increased expression of JAK2 protein]] CTD PMID:16534557 NCBI chr 1:247,398,667...247,457,521
Ensembl chr 1:247,398,598...247,458,509
JBrowse link
G Klf2 Kruppel-like factor 2 multiple interactions ISO Mevalonic Acid inhibits the reaction [Simvastatin results in increased expression of KLF2 mRNA] CTD PMID:20493886 NCBI chr16:19,223,087...19,225,037
Ensembl chr16:19,223,087...19,225,037
JBrowse link
G Lep leptin multiple interactions ISO Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of LEP mRNA]; Mevalonic Acid inhibits the reaction [Simvastatin results in decreased secretion of LEP protein] CTD PMID:19254925 NCBI chr 4:56,337,695...56,351,818
Ensembl chr 4:56,337,695...56,351,818
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO
EXP
Mevalonic Acid inhibits the reaction [Atorvastatin results in decreased phosphorylation of MAPK1 protein]
Mevalonic Acid inhibits the reaction [Atorvastatin results in increased phosphorylation of MAPK1 protein]; Mevalonic Acid inhibits the reaction [Lovastatin results in decreased phosphorylation of MAPK1 protein]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [Acrolein results in increased phosphorylation of MAPK1 protein]]
CTD PMID:16470222, PMID:16952276, PMID:18339080, PMID:20359552 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO
EXP
Mevalonic Acid inhibits the reaction [Atorvastatin results in decreased phosphorylation of MAPK3 protein]
Mevalonic Acid inhibits the reaction [Atorvastatin results in increased phosphorylation of MAPK3 protein]; Mevalonic Acid inhibits the reaction [Lovastatin results in decreased phosphorylation of MAPK3 protein]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [Acrolein results in increased phosphorylation of MAPK3 protein]]
CTD PMID:16470222, PMID:16952276, PMID:18339080, PMID:20359552 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mmp1 matrix metallopeptidase 1 multiple interactions ISO Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [Lipopolysaccharides results in increased secretion of MMP1 protein]]; Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of MMP1 mRNA]; Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of MMP1 protein]; Mevalonic Acid inhibits the reaction [Simvastatin results in decreased secretion of MMP1 protein] CTD PMID:17303772, PMID:18625914 NCBI chr 8:5,703,206...5,723,593
Ensembl chr 8:5,703,206...5,723,591
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [[IL1A co-treated with PDGFB] results in increased secretion of MMP9 protein]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of MMP9 protein]] CTD PMID:15728660 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Mttp microsomal triglyceride transfer protein multiple interactions EXP Mevalonic Acid inhibits the reaction [Atorvastatin results in increased expression of MTTP mRNA] CTD PMID:12056585 NCBI chr 2:243,366,181...243,407,608
Ensembl chr 2:243,366,181...243,407,608
JBrowse link
G Muc5ac mucin 5AC, oligomeric mucus/gel-forming multiple interactions ISO Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [Acrolein results in increased expression of MUC5AC protein]] CTD PMID:20359552 NCBI chr 1:214,725,482...214,756,653 JBrowse link
G Mvk mevalonate kinase increases phosphorylation
multiple interactions
ISO MVK protein results in increased phosphorylation of Mevalonic Acid
3,3-dimethylallyl pyrophosphate inhibits the reaction [MVK protein results in increased phosphorylation of Mevalonic Acid]; dolichol monophosphate inhibits the reaction [MVK protein results in increased phosphorylation of Mevalonic Acid]; Farnesol inhibits the reaction [MVK protein results in increased phosphorylation of Mevalonic Acid]; farnesyl pyrophosphate inhibits the reaction [MVK protein results in increased phosphorylation of Mevalonic Acid]; geranyl diphosphate inhibits the reaction [MVK protein results in increased phosphorylation of Mevalonic Acid]; geranylgeranyl pyrophosphate inhibits the reaction [MVK protein results in increased phosphorylation of Mevalonic Acid]; isopentenyl pyrophosphate inhibits the reaction [MVK protein results in increased phosphorylation of Mevalonic Acid]
CTD PMID:9392419 NCBI chr12:47,904,266...47,920,457
Ensembl chr12:47,904,719...47,919,400
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions EXP Mevalonic Acid affects the reaction [Simvastatin results in increased localization of NFE2L2 protein] CTD PMID:18787804 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO Mevalonic Acid inhibits the reaction [Asbestos, Crocidolite affects the localization of NFKB1 protein]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]] CTD PMID:17277159, PMID:17322126 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO Mevalonic Acid inhibits the reaction [Asbestos, Crocidolite results in decreased expression of and results in increased phosphorylation of NFKBIA protein]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased degradation of NFKBIA protein]] CTD PMID:17075836, PMID:17322126 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP
ISO
Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IL1A results in decreased expression of NOS2 protein]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [TNF results in decreased expression of NOS2 protein]]
Mevalonic Acid inhibits the reaction [fluvastatin results in increased expression of NOS2 protein]
Mevalonic Acid inhibits the reaction [Simvastatin promotes the reaction [[Lipopolysaccharides co-treated with TNF] results in increased expression of NOS2 mRNA]]
CTD PMID:15705589, PMID:17729120, PMID:24964743 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions ISO Mevalonic Acid inhibits the reaction [Simvastatin results in increased expression of NOS3 mRNA]; Mevalonic Acid inhibits the reaction [Y 27632 results in increased phosphorylation of NOS3 protein] CTD PMID:17322126, PMID:20493886 NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410
JBrowse link
G Nppa natriuretic peptide A multiple interactions EXP Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [CTF1 results in increased expression of NPPA mRNA]] CTD PMID:16534557 NCBI chr 5:164,808,407...164,809,716
Ensembl chr 5:164,808,323...164,809,705
JBrowse link
G Nr4a3 nuclear receptor subfamily 4, group A, member 3 multiple interactions ISO Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of NR4A3 mRNA] CTD PMID:16005304 NCBI chr 5:63,781,801...63,822,890
Ensembl chr 5:63,781,801...63,821,637
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO Mevalonic Acid inhibits the reaction [Simvastatin promotes the reaction [TNFSF10 protein results in increased cleavage of PARP1 protein]]; Mevalonic Acid inhibits the reaction [Simvastatin results in increased cleavage of PARP1 protein]; Mevalonic Acid inhibits the reaction [TNFSF10 protein promotes the reaction [Simvastatin results in increased cleavage of PARP1 protein]] CTD PMID:20045437, PMID:21910007 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions ISO Mevalonic Acid inhibits the reaction [Asbestos, Crocidolite results in increased expression of PCNA protein]; Mevalonic Acid inhibits the reaction [Clostridium difficile lethal toxin B results in increased expression of PCNA protein]; Mevalonic Acid inhibits the reaction [Y 27632 results in increased expression of PCNA protein] CTD PMID:17322126 NCBI chr 3:124,880,698...124,884,570
Ensembl chr 3:124,880,698...124,884,570
JBrowse link
G Pcyt1a phosphate cytidylyltransferase 1, choline, alpha increases activity
increases expression
EXP Mevalonic Acid results in increased activity of PCYT1A protein
Mevalonic Acid results in increased expression of PCYT1A mRNA
CTD PMID:12056585 NCBI chr11:71,547,865...71,592,037
Ensembl chr11:71,548,222...71,591,502
JBrowse link
G Pdgfb platelet derived growth factor subunit B multiple interactions ISO Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [[IL1A co-treated with PDGFB] results in increased secretion of MMP9 protein]]; Mevalonic Acid inhibits the reaction [Simvastatin results in decreased activity of PDGFB protein] CTD PMID:8231022, PMID:15728660 NCBI chr 7:121,215,458...121,233,092
Ensembl chr 7:121,214,628...121,232,741
JBrowse link
G Pdk4 pyruvate dehydrogenase kinase 4 multiple interactions EXP Mevalonic Acid inhibits the reaction [Atorvastatin inhibits the reaction [TNF protein results in decreased expression of PDK4 protein]] CTD PMID:22343369 NCBI chr 4:30,546,772...30,556,774
Ensembl chr 4:30,546,664...30,556,814
JBrowse link
G Plat plasminogen activator, tissue type multiple interactions EXP
ISO
Mevalonic Acid inhibits the reaction [Lovastatin results in increased expression of PLAT protein]
Mevalonic Acid inhibits the reaction [Simvastatin results in increased expression of PLAT mRNA]; Mevalonic Acid inhibits the reaction [Simvastatin results in increased expression of PLAT]
CTD PMID:10412747, PMID:12371961, PMID:12753293 NCBI chr16:74,098,263...74,122,897
Ensembl chr16:74,098,260...74,122,889
JBrowse link
G Pon1 paraoxonase 1 multiple interactions ISO Mevalonic Acid inhibits the reaction [pitavastatin results in increased expression of PON1 mRNA]; Mevalonic Acid inhibits the reaction [Simvastatin promotes the reaction [SREBF2 protein binds to PON1 promoter]]; Mevalonic Acid inhibits the reaction [Simvastatin results in increased expression of PON1 mRNA] CTD PMID:14500290, PMID:15690306 NCBI chr 4:30,249,749...30,276,297
Ensembl chr 4:30,249,742...30,276,372
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions ISO Mevalonic Acid inhibits the reaction [cerivastatin promotes the reaction [Bezafibrate results in increased activity of [PPARA protein binds to RXRA protein]]] CTD PMID:11779144 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions EXP Mevalonic Acid inhibits the reaction [Lovastatin results in increased expression of PPARG mRNA] CTD PMID:20578043 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Prkcd protein kinase C, delta multiple interactions EXP Mevalonic Acid inhibits the reaction [Lovastatin results in increased cleavage of PRKCD protein] CTD PMID:16367743 NCBI chr16:6,655,131...6,675,746
Ensembl chr16:6,655,120...6,675,746
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO Mevalonic Acid affects the reaction [Lovastatin analog results in increased expression of PTGS2 protein]; Mevalonic Acid inhibits the reaction [Simvastatin promotes the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA]] CTD PMID:18612546, PMID:26863638 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Pxn paxillin multiple interactions EXP Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [AGT protein results in increased phosphorylation of PXN protein]] CTD PMID:22306966 NCBI chr12:46,797,953...46,845,107
Ensembl chr12:46,797,954...46,845,080
JBrowse link
G Rac1 Rac family small GTPase 1 multiple interactions ISO
EXP
Mevalonic Acid inhibits the reaction [Lovastatin affects the localization of RAC1 protein]
Mevalonic Acid inhibits the reaction [Simvastatin results in increased expression of RAC1 protein]
CTD PMID:12933658, PMID:16698853 NCBI chr12:13,090,316...13,111,841
Ensembl chr12:13,090,172...13,111,873
JBrowse link
G Rap1a RAP1A, member of RAS oncogene family multiple interactions ISO Mevalonic Acid affects the reaction [Menthol analog results in increased expression of RAP1A protein]; Mevalonic Acid affects the reaction [Menthol results in increased expression of RAP1A protein]; Mevalonic Acid affects the reaction [myrtenol results in increased expression of RAP1A protein]; Mevalonic Acid affects the reaction [perillaldehyde results in increased expression of RAP1A protein]; Mevalonic Acid affects the reaction [perillyl alcohol results in increased expression of RAP1A protein]; Mevalonic Acid inhibits the reaction [cerivastatin results in decreased geranoylation of RAP1A protein]; Mevalonic Acid inhibits the reaction [Simvastatin results in decreased geranoylation of RAP1A protein] CTD PMID:12671036, PMID:25578243 NCBI chr 2:208,193,950...208,215,186
Ensembl chr 2:208,193,954...208,215,187
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP
ISO
Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IL1A results in increased localization of RELA protein]]
Mevalonic Acid inhibits the reaction [Asbestos, Crocidolite affects the localization of RELA protein]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]]
CTD PMID:15705589, PMID:17277159, PMID:17322126 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Retn resistin multiple interactions ISO Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [CRP results in increased expression of RETN mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [CRP results in increased secretion of RETN protein]] CTD PMID:18023360 NCBI chr12:2,201,909...2,203,649
Ensembl chr12:2,201,891...2,204,249
JBrowse link
G Rhoa ras homolog family member A multiple interactions EXP
ISO
Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of RHOA protein]
Mevalonic Acid affects the reaction [2-methyl-5-(1-methylethenyl)cyclohexanol results in increased expression of RHOA protein]; Mevalonic Acid affects the reaction [carvone results in increased expression of RHOA protein]; Mevalonic Acid affects the reaction [Menthol analog results in increased expression of RHOA protein]; Mevalonic Acid affects the reaction [myrtenol results in increased expression of RHOA protein]; Mevalonic Acid affects the reaction [perillaldehyde results in increased expression of RHOA protein]; Mevalonic Acid affects the reaction [perillic acid results in increased expression of RHOA protein]; Mevalonic Acid affects the reaction [perillyl alcohol results in increased expression of RHOA protein]; Mevalonic Acid inhibits the reaction [Asbestos, Crocidolite results in decreased activity of and results in decreased lipidation of RHOA protein]; Mevalonic Acid inhibits the reaction [Atorvastatin results in decreased activity of RHOA protein]; Mevalonic Acid inhibits the reaction [Atorvastatin results in increased localization of RHOA protein]; Mevalonic Acid inhibits the reaction [Lovastatin affects the localization of RHOA protein]; Mevalonic Acid inhibits the reaction [mevastatin results in decreased lipidation of RHOA protein]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased activity of RHOA protein]]; Mevalonic Acid inhibits the reaction [Simvastatin results in decreased activity of RHOA protein]; Mevalonic Acid inhibits the reaction [Simvastatin results in decreased geranoylation of and affects the localization of RHOA protein]; Mevalonic Acid inhibits the reaction [Simvastatin results in increased localization of RHOA protein]
CTD PMID:12477733, PMID:12671036, PMID:12933658, PMID:16005304, PMID:16470222, PMID:16698853, PMID:17075836, PMID:17322126 NCBI chr 8:117,082,440...117,116,244
Ensembl chr 8:117,106,576...117,116,167
JBrowse link
G Rhob ras homolog family member B multiple interactions ISO Mevalonic Acid affects the reaction [2-methyl-5-(1-methylethenyl)cyclohexanol results in increased expression of RHOB protein]; Mevalonic Acid affects the reaction [carveol results in increased expression of RHOB protein]; Mevalonic Acid affects the reaction [carvone results in increased expression of RHOB protein]; Mevalonic Acid affects the reaction [Menthol analog results in increased expression of RHOB protein]; Mevalonic Acid affects the reaction [Menthol results in increased expression of RHOB protein]; Mevalonic Acid affects the reaction [myrtenol results in increased expression of RHOB protein]; Mevalonic Acid affects the reaction [perillaldehyde results in increased expression of RHOB protein]; Mevalonic Acid affects the reaction [perillic acid results in increased expression of RHOB protein]; Mevalonic Acid affects the reaction [perillyl alcohol results in increased expression of RHOB protein] CTD PMID:12671036 NCBI chr 6:33,689,127...33,691,301
Ensembl chr 6:33,689,127...33,691,301
JBrowse link
G Rorc RAR-related orphan receptor C multiple interactions ISO Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of RORC mRNA] CTD PMID:18453621 NCBI chr 2:195,612,471...195,636,797
Ensembl chr 2:195,617,021...195,637,630
JBrowse link
G RT1-Da RT1 class II, locus Da multiple interactions ISO Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of HLA-DRA protein]] CTD PMID:11219190 NCBI chr20:4,127,644...4,132,616
Ensembl chr20:4,127,644...4,132,616
JBrowse link
G Rxra retinoid X receptor alpha multiple interactions ISO Mevalonic Acid inhibits the reaction [cerivastatin promotes the reaction [Bezafibrate results in increased activity of [PPARA protein binds to RXRA protein]]] CTD PMID:11779144 NCBI chr 3:6,272,560...6,295,354
Ensembl chr 3:6,211,789...6,295,908
JBrowse link
G Sele selectin E multiple interactions ISO Mevalonic Acid inhibits the reaction [Simvastatin promotes the reaction [IL1B protein results in increased expression of SELE protein]] CTD PMID:10946302 NCBI chr13:82,355,234...82,365,323
Ensembl chr13:82,355,471...82,365,341
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions ISO Mevalonic Acid inhibits the reaction [fluvastatin results in increased expression of SOD2 protein] CTD PMID:24964743 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Srebf2 sterol regulatory element binding transcription factor 2 multiple interactions ISO
EXP
Mevalonic Acid inhibits the reaction [Simvastatin promotes the reaction [SREBF2 protein binds to PON1 promoter]]
Mevalonic Acid inhibits the reaction [Atorvastatin results in increased expression of SREBF2 mRNA]; Mevalonic Acid inhibits the reaction [Simvastatin results in increased expression of SREBF2 mRNA]
CTD PMID:12056585, PMID:14500290 NCBI chr 7:123,381,082...123,438,605
Ensembl chr 7:123,381,077...123,438,603
JBrowse link
G Stat1 signal transducer and activator of transcription 1 multiple interactions
increases expression
ISO
EXP
Mevalonic Acid inhibits the reaction [Simvastatin results in decreased phosphorylation of STAT1 protein]
Mevalonic Acid results in increased expression of STAT1 protein
Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [CTF1 results in increased expression of STAT1 protein]]
Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of STAT1 mRNA]; Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of STAT1 protein]
CTD PMID:16534557, PMID:17507688, PMID:18453621 NCBI chr 9:54,287,540...54,327,958
Ensembl chr 9:54,287,541...54,484,533
JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO
EXP
Mevalonic Acid inhibits the reaction [Simvastatin results in decreased phosphorylation of STAT3 protein]
Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [CTF1 results in increased expression of STAT3 protein]]
CTD PMID:16534557, PMID:18453621 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233
JBrowse link
G Tfrc transferrin receptor multiple interactions ISO Mevalonic Acid inhibits the reaction [fluvastatin results in decreased expression of TFRC mRNA]; Mevalonic Acid inhibits the reaction [fluvastatin results in decreased expression of TFRC protein] CTD PMID:24964743 NCBI chr11:71,397,423...71,419,263
Ensembl chr11:71,397,383...71,419,223
JBrowse link
G Th tyrosine hydroxylase multiple interactions ISO Mevalonic Acid inhibits the reaction [Lovastatin results in increased expression of TH protein] CTD PMID:20694854 NCBI chr 1:216,073,034...216,080,287
Ensembl chr 1:216,073,031...216,080,287
JBrowse link
G Thbd thrombomodulin multiple interactions ISO Mevalonic Acid inhibits the reaction [Simvastatin results in increased expression of THBD mRNA] CTD PMID:20493886 NCBI chr 3:142,748,673...142,752,325
Ensembl chr 3:142,748,674...142,752,325
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP
Mevalonic Acid inhibits the reaction [Atorvastatin inhibits the reaction [TNF results in increased expression of CCL2 mRNA]]; Mevalonic Acid inhibits the reaction [Atorvastatin inhibits the reaction [TNF results in increased expression of CXCL8 mRNA]]; Mevalonic Acid inhibits the reaction [Atorvastatin inhibits the reaction [TNF results in increased expression of IL6 mRNA]]; Mevalonic Acid inhibits the reaction [cerivastatin inhibits the reaction [TNF results in increased expression of CCL2 mRNA]]; Mevalonic Acid inhibits the reaction [cerivastatin inhibits the reaction [TNF results in increased expression of CXCL8 mRNA]]; Mevalonic Acid inhibits the reaction [cerivastatin inhibits the reaction [TNF results in increased expression of IL6 mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased activity of RHOA protein]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased degradation of NFKBIA protein]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased expression of CCL2 mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased expression of CCL4 mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased expression of CCR4 mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased expression of CXCL8 mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased expression of ICAM1 mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased expression of IL6 mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased expression of VCAM1 mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased secretion of IL1B protein]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased secretion of IL6 protein]]
Mevalonic Acid inhibits the reaction [Atorvastatin inhibits the reaction [TNF protein results in decreased expression of PDK4 protein]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [Acrolein results in increased secretion of TNF protein]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [TNF results in decreased expression of NOS2 protein]]
Mevalonic Acid inhibits the reaction [Simvastatin promotes the reaction [[Lipopolysaccharides co-treated with TNF] results in increased abundance of Nitric Oxide]]; Mevalonic Acid inhibits the reaction [Simvastatin promotes the reaction [[Lipopolysaccharides co-treated with TNF] results in increased expression of IL6 protein]]; Mevalonic Acid inhibits the reaction [Simvastatin promotes the reaction [[Lipopolysaccharides co-treated with TNF] results in increased expression of NOS2 mRNA]]
CTD PMID:12117737, PMID:15705589, PMID:16321392, PMID:16511915, PMID:17075836, PMID:17277159, PMID:17729120, PMID:20359552, PMID:20863785, PMID:22343369 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tnfrsf4 TNF receptor superfamily member 4 multiple interactions ISO Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of TNFRSF4 mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of TNFRSF4 protein]] CTD PMID:19589242 NCBI chr 5:173,447,784...173,450,474
Ensembl chr 5:173,447,784...173,450,474
JBrowse link
G Tnfsf10 TNF superfamily member 10 multiple interactions ISO Mevalonic Acid inhibits the reaction [Simvastatin promotes the reaction [TNFSF10 protein results in increased cleavage of PARP1 protein]]; Mevalonic Acid inhibits the reaction [TNFSF10 protein promotes the reaction [Simvastatin results in increased cleavage of PARP1 protein]] CTD PMID:21910007 NCBI chr 2:113,008,008...113,026,899
Ensembl chr 2:113,007,549...113,026,899
JBrowse link
G Tnfsf4 TNF superfamily member 4 multiple interactions ISO Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of TNFSF4 mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of TNFSF4 protein]] CTD PMID:19589242 NCBI chr13:79,269,973...79,293,775
Ensembl chr13:79,269,973...79,293,778
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [CD40LG results in increased expression of VCAM1 mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased expression of VCAM1 mRNA]] CTD PMID:18269829, PMID:20863785 NCBI chr 2:219,071,193...219,090,931
Ensembl chr 2:219,071,193...219,097,619
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IL6 results in increased expression of VEGFA mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IL6 results in increased expression of VEGFA protein]]; Mevalonic Acid inhibits the reaction [Simvastatin results in increased expression of VEGFA mRNA] CTD PMID:16424782, PMID:18356691 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      biological role 19734
        biochemical role 19282
          metabolite 19263
            mevalonic acid 109
              (R)-3-phosphomevalonic acid 0
              (R)-5-diphosphomevalonic acid 0
              (R)-5-phosphomevalonic acid 0
              (R)-mevalonic acid 109
              (S)-mevalonic acid 0
              mevalonyl-CoA 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    p-block element atom 19672
                      carbon group element atom 19574
                        carbon atom 19563
                          organic molecular entity 19563
                            organic group 18495
                              organic divalent group 18488
                                organodiyl group 18488
                                  carbonyl group 18391
                                    carbonyl compound 18391
                                      carboxylic acid 18061
                                        monocarboxylic acid 17407
                                          fatty acid 15845
                                            saturated fatty acid 15812
                                              straight-chain saturated fatty acid 15227
                                                valeric acid 14336
                                                  mevalonic acid 109
                                                    (R)-3-phosphomevalonic acid 0
                                                    (R)-5-diphosphomevalonic acid 0
                                                    (R)-5-phosphomevalonic acid 0
                                                    (R)-mevalonic acid 109
                                                    (S)-mevalonic acid 0
                                                    mevalonyl-CoA 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.