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G |
Abca1 |
ATP binding cassette subfamily A member 1 |
multiple interactions |
ISO |
Mevalonic Acid inhibits the reaction [mevastatin inhibits the reaction [8-((4-chlorophenyl)thio)cyclic-3',5'-AMP results in increased expression of ABCA1 protein]] |
CTD |
PMID:16415093 |
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NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170
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G |
Acacb |
acetyl-CoA carboxylase beta |
multiple interactions |
EXP |
Mevalonic Acid inhibits the reaction [Atorvastatin results in increased expression of ACACB mRNA] |
CTD |
PMID:12056585 |
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NCBI chr12:42,365,800...42,477,651
Ensembl chr12:42,366,548...42,457,655
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G |
Acan |
aggrecan |
multiple interactions |
EXP |
Mevalonic Acid inhibits the reaction [Simvastatin results in increased expression of ACAN mRNA] |
CTD |
PMID:18628692 |
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NCBI chr 1:132,981,582...133,044,416
Ensembl chr 1:132,981,582...133,043,627
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G |
Agt |
angiotensinogen |
multiple interactions |
EXP |
Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [AGT protein results in increased phosphorylation of PXN protein]] |
CTD |
PMID:22306966 |
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NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
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G |
Akt1 |
AKT serine/threonine kinase 1 |
multiple interactions |
ISO |
Mevalonic Acid inhibits the reaction [Asbestos, Crocidolite results in increased activity of AKT1 protein]; Mevalonic Acid inhibits the reaction [Asbestos, Crocidolite results in increased expression of AKT1 mRNA] Mevalonic Acid inhibits the reaction [Simvastatin results in decreased phosphorylation of AKT1 protein] |
CTD |
PMID:17322126 PMID:33034787 |
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NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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G |
Bbc3 |
Bcl-2 binding component 3 |
multiple interactions |
ISO |
Mevalonic Acid inhibits the reaction [Simvastatin results in increased expression of BBC3 protein] |
CTD |
PMID:20045437 |
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NCBI chr 1:77,013,281...77,022,509
Ensembl chr 1:77,014,543...77,022,509
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G |
Bcar1 |
BCAR1 scaffold protein, Cas family member |
multiple interactions |
EXP |
Mevalonic Acid inhibits the reaction [Lovastatin results in increased cleavage of BCAR1 protein] |
CTD |
PMID:16367743 |
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NCBI chr19:39,679,215...39,713,907
Ensembl chr19:39,679,204...39,713,907
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G |
Bcl2 |
BCL2, apoptosis regulator |
multiple interactions |
ISO EXP |
Mevalonic Acid inhibits the reaction [Lovastatin results in decreased expression of BCL2 protein] |
CTD |
PMID:11178870 PMID:12094262 |
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NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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G |
Bcl2l1 |
Bcl2-like 1 |
multiple interactions |
EXP |
Mevalonic Acid inhibits the reaction [Lovastatin results in decreased expression of BCL2L1 protein] |
CTD |
PMID:11178870 |
|
NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
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G |
Bid |
BH3 interacting domain death agonist |
multiple interactions |
EXP |
Mevalonic Acid inhibits the reaction [Atorvastatin results in decreased expression of and results in increased cleavage of BID protein] |
CTD |
PMID:18339080 |
|
NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720
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G |
Bmp2 |
bone morphogenetic protein 2 |
multiple interactions |
EXP ISO |
Mevalonic Acid inhibits the reaction [Simvastatin results in increased expression of BMP2 mRNA] |
CTD |
PMID:10814523 PMID:18628692 |
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NCBI chr 3:120,812,660...120,822,579
Ensembl chr 3:120,812,882...120,821,397
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G |
Cacna1c |
calcium voltage-gated channel subunit alpha1 C |
multiple interactions |
EXP |
Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of CACNA1C mRNA]; Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of CACNA1C protein]; Mevalonic Acid inhibits the reaction [Verapamil results in decreased expression of CACNA1C mRNA]; Mevalonic Acid inhibits the reaction [Verapamil results in decreased expression of CACNA1C protein] |
CTD |
PMID:19791473 |
|
NCBI chr 4:151,764,138...152,379,454
Ensembl chr 4:151,764,138...152,379,648
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G |
Cacna1h |
calcium voltage-gated channel subunit alpha1 H |
multiple interactions |
EXP |
Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of CACNA1H mRNA]; Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of CACNA1H protein]; Mevalonic Acid inhibits the reaction [Verapamil results in decreased expression of CACNA1H mRNA]; Mevalonic Acid inhibits the reaction [Verapamil results in decreased expression of CACNA1H protein] |
CTD |
PMID:19791473 |
|
NCBI chr10:14,390,104...14,448,204
Ensembl chr10:14,390,113...14,448,376
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G |
Casp3 |
caspase 3 |
multiple interactions |
ISO EXP |
Mevalonic Acid inhibits the reaction [Atorvastatin results in increased activity of CASP3 protein]; Mevalonic Acid inhibits the reaction [cerivastatin results in increased activity of CASP3 protein]; Mevalonic Acid inhibits the reaction [Fluvastatin results in increased cleavage of and results in increased activity of CASP3 protein]; Mevalonic Acid inhibits the reaction [Simvastatin results in increased activity of CASP3 protein]; Mevalonic Acid inhibits the reaction [Simvastatin results in increased expression of CASP3 protein] Mevalonic Acid inhibits the reaction [Atorvastatin results in increased activity of CASP3 protein]; Mevalonic Acid inhibits the reaction [Lovastatin results in increased activity of and results in increased cleavage of CASP3 protein]; Mevalonic Acid inhibits the reaction [Simvastatin results in increased activity of CASP3 protein] |
CTD |
PMID:15949312 PMID:16367743 PMID:16470222 PMID:16698853 PMID:17428261 PMID:18339080 PMID:20427495 PMID:24964743 More...
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|
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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G |
Casp7 |
caspase 7 |
multiple interactions |
ISO |
Mevalonic Acid inhibits the reaction [Simvastatin results in increased activity of CASP7 protein]; Mevalonic Acid inhibits the reaction [Simvastatin results in increased cleavage of CASP7 protein] |
CTD |
PMID:20045437 PMID:20427495 |
|
NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729
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G |
Casp8 |
caspase 8 |
multiple interactions |
ISO |
Mevalonic Acid inhibits the reaction [Fluvastatin results in increased activity of CASP8 protein] |
CTD |
PMID:24964743 |
|
NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
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G |
Casp9 |
caspase 9 |
multiple interactions |
ISO EXP |
Mevalonic Acid inhibits the reaction [Simvastatin results in increased cleavage of CASP9 protein] Mevalonic Acid inhibits the reaction [Atorvastatin results in increased activity of CASP9 protein] |
CTD |
PMID:18339080 PMID:20045437 |
|
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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G |
Ccl2 |
C-C motif chemokine ligand 2 |
multiple interactions |
ISO |
Mevalonic Acid inhibits the reaction [Atorvastatin inhibits the reaction [TNF results in increased expression of CCL2 mRNA]]; Mevalonic Acid inhibits the reaction [Atorvastatin results in decreased expression of CCL2 mRNA]; Mevalonic Acid inhibits the reaction [cerivastatin inhibits the reaction [TNF results in increased expression of CCL2 mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of CCL2 mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased expression of CCL2 mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of CCL2 mRNA] |
CTD |
PMID:12117737 PMID:16321392 |
|
NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
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G |
Ccl3 |
C-C motif chemokine ligand 3 |
multiple interactions |
ISO |
Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of CCL3 mRNA]] |
CTD |
PMID:16321392 |
|
NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938
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G |
Ccl4 |
C-C motif chemokine ligand 4 |
multiple interactions |
ISO |
Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of CCL4 mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased expression of CCL4 mRNA]] |
CTD |
PMID:16321392 |
|
NCBI chr10:68,466,394...68,468,229
Ensembl chr10:68,452,052...68,468,231
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G |
Ccna2 |
cyclin A2 |
multiple interactions |
EXP |
Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of CCNA2 protein] |
CTD |
PMID:26577051 |
|
NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577
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G |
Ccne1 |
cyclin E1 |
multiple interactions |
EXP |
Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of CCNE1 protein] |
CTD |
PMID:26577051 |
|
NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101
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G |
Ccr1 |
C-C motif chemokine receptor 1 |
multiple interactions |
ISO |
Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of CCR1 mRNA]] |
CTD |
PMID:16321392 |
|
NCBI chr 8:123,556,286...123,561,841
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G |
Ccr2 |
C-C motif chemokine receptor 2 |
multiple interactions |
ISO |
Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of CCR2 mRNA]] |
CTD |
PMID:16321392 |
|
NCBI chr 8:123,734,465...123,742,483
Ensembl chr 8:123,734,430...123,742,100
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G |
Ccr4 |
C-C motif chemokine receptor 4 |
multiple interactions |
ISO |
Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased expression of CCR4 mRNA]] |
CTD |
PMID:16321392 |
|
NCBI chr 8:114,176,291...114,182,033
Ensembl chr 8:114,176,974...114,178,056
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G |
Ccr5 |
C-C motif chemokine receptor 5 |
multiple interactions |
ISO |
Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of CCR5 mRNA]] |
CTD |
PMID:16321392 |
|
NCBI chr 8:123,752,423...123,757,538
Ensembl chr 8:123,752,325...123,759,260
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G |
Cd40 |
CD40 molecule |
multiple interactions |
ISO |
Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of CD40 mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of CD40 protein]] |
CTD |
PMID:17507688 |
|
NCBI chr 3:153,790,372...153,805,279
Ensembl chr 3:153,790,449...153,805,534
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G |
Cd40lg |
CD40 ligand |
multiple interactions |
ISO |
Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [CD40LG results in increased expression of VCAM1 mRNA]] |
CTD |
PMID:18269829 |
|
NCBI chr X:135,127,052...135,138,768
Ensembl chr X:135,126,969...135,138,306
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G |
Cd44 |
CD44 molecule |
multiple interactions |
ISO |
Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of CD44 protein] |
CTD |
PMID:21199873 |
|
NCBI chr 3:89,155,850...89,244,615
Ensembl chr 3:89,157,058...89,244,620
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G |
Cdk1 |
cyclin-dependent kinase 1 |
multiple interactions |
EXP |
Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of CDK1 protein] |
CTD |
PMID:26577051 |
|
NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408
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G |
Cdk2 |
cyclin dependent kinase 2 |
multiple interactions |
EXP |
Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of CDK2 protein] |
CTD |
PMID:26577051 |
|
NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403
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G |
Cenpf |
centromere protein F |
multiple interactions |
ISO |
Mevalonic Acid inhibits the reaction [Lovastatin results in increased expression of CENPF protein]; Mevalonic Acid inhibits the reaction [Paclitaxel results in increased expression of CENPF protein] |
CTD |
PMID:12467231 |
|
NCBI chr13:101,184,127...101,229,714
Ensembl chr13:101,184,127...101,229,669
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G |
Chuk |
component of inhibitor of nuclear factor kappa B kinase complex |
decreases phosphorylation multiple interactions |
ISO |
Mevalonic Acid results in decreased phosphorylation of CHUK protein Mevalonic Acid inhibits the reaction [Asbestos, Crocidolite results in increased activity of and results in increased phosphorylation of CHUK protein] |
CTD |
PMID:17322126 |
|
NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:242,959,760...242,995,065
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G |
Col1a1 |
collagen type I alpha 1 chain |
multiple interactions |
ISO |
Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of COL1A1 mRNA] |
CTD |
PMID:16575855 |
|
NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
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G |
Col2a1 |
collagen type II alpha 1 chain |
multiple interactions |
EXP |
Mevalonic Acid inhibits the reaction [Simvastatin results in increased expression of COL2A1 mRNA] |
CTD |
PMID:18628692 |
|
NCBI chr 7:129,098,489...129,127,560
Ensembl chr 7:129,098,786...129,127,546
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G |
Crp |
C-reactive protein |
multiple interactions |
ISO |
Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [CRP results in increased expression of RETN mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [CRP results in increased secretion of RETN protein]] |
CTD |
PMID:18023360 |
|
NCBI chr13:85,135,384...85,175,178
Ensembl chr13:85,124,977...85,175,178
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G |
Ctf1 |
cardiotrophin 1 |
multiple interactions |
EXP |
Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [CTF1 results in increased expression of JAK1 protein]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [CTF1 results in increased expression of JAK2 protein]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [CTF1 results in increased expression of NPPA mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [CTF1 results in increased expression of STAT1 protein]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [CTF1 results in increased expression of STAT3 protein]] |
CTD |
PMID:16534557 |
|
NCBI chr 1:182,328,035...182,336,346
Ensembl chr 1:182,328,090...182,333,335
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G |
Ddb2 |
damage specific DNA binding protein 2 |
multiple interactions |
ISO |
Mevalonic Acid inhibits the reaction [Fluvastatin results in decreased expression of DDB2 mRNA]; Mevalonic Acid inhibits the reaction [Fluvastatin results in decreased expression of DDB2 protein] |
CTD |
PMID:24964743 |
|
NCBI chr 3:77,185,114...77,207,650
Ensembl chr 3:77,185,109...77,207,631
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G |
Dgat1 |
diacylglycerol O-acyltransferase 1 |
multiple interactions |
EXP |
Mevalonic Acid inhibits the reaction [Atorvastatin results in increased activity of DGAT1 protein] |
CTD |
PMID:12056585 |
|
NCBI chr 7:108,223,860...108,235,413
Ensembl chr 7:108,218,524...108,234,299
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G |
Edn1 |
endothelin 1 |
multiple interactions |
ISO |
Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of EDN1 mRNA]; Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of EDN1 protein] |
CTD |
PMID:18390205 |
|
NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
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G |
Egfr |
epidermal growth factor receptor |
multiple interactions |
EXP |
Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [Acrolein results in increased phosphorylation of EGFR protein]] |
CTD |
PMID:20359552 |
|
NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382
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G |
F3 |
coagulation factor III, tissue factor |
multiple interactions |
ISO |
Mevalonic Acid inhibits the reaction [Fluvastatin results in decreased expression of F3 mRNA]; Mevalonic Acid inhibits the reaction [Fluvastatin results in decreased expression of F3 protein]; Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of F3] |
CTD |
PMID:9081680 PMID:12753293 |
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NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668
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G |
Fasn |
fatty acid synthase |
multiple interactions |
EXP |
Mevalonic Acid inhibits the reaction [Atorvastatin results in increased expression of FASN mRNA] |
CTD |
PMID:12056585 |
|
NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261
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G |
Fbxo32 |
F-box protein 32 |
multiple interactions |
ISO |
Mevalonic Acid inhibits the reaction [Lovastatin results in increased expression of FBXO32 mRNA]; Mevalonic Acid inhibits the reaction [Lovastatin results in increased expression of FBXO32 protein] |
CTD |
PMID:19406843 |
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NCBI chr 7:89,731,428...89,764,997
Ensembl chr 7:89,730,232...89,765,436
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G |
Foxo1 |
forkhead box O1 |
multiple interactions |
ISO |
Mevalonic Acid inhibits the reaction [Simvastatin results in decreased phosphorylation of and affects the localization of FOXO1 protein] |
CTD |
PMID:33034787 |
|
NCBI chr 2:136,312,168...136,390,603
Ensembl chr 2:136,312,168...136,387,790
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G |
Foxp3 |
forkhead box P3 |
multiple interactions |
ISO |
Mevalonic Acid inhibits the reaction [Simvastatin results in increased expression of FOXP3] |
CTD |
PMID:20408897 |
|
NCBI chr X:14,908,494...14,924,994
Ensembl chr X:14,908,494...14,923,838
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G |
Hmgcr |
3-hydroxy-3-methylglutaryl-CoA reductase |
decreases activity multiple interactions |
ISO EXP |
Mevalonic Acid results in decreased activity of HMGCR protein [25-hydroxycholesterol co-treated with Mevalonic Acid] results in increased ubiquitination of HMGCR protein Mevalonic Acid inhibits the reaction [Atorvastatin results in increased activity of HMGCR protein]; Mevalonic Acid inhibits the reaction [Atorvastatin results in increased expression of HMGCR mRNA]; Mevalonic Acid inhibits the reaction [Clofibrate results in decreased expression of HMGCR mRNA]; Mevalonic Acid inhibits the reaction [Simvastatin results in increased activity of HMGCR protein]; Mevalonic Acid inhibits the reaction [Simvastatin results in increased expression of HMGCR mRNA] |
CTD |
PMID:12056585 PMID:12477733 PMID:12518023 PMID:21944868 |
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NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703
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G |
Icam1 |
intercellular adhesion molecule 1 |
multiple interactions |
ISO |
Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased expression of ICAM1 mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin promotes the reaction [IL1B protein results in increased expression of ICAM1 protein]] |
CTD |
PMID:10946302 PMID:20863785 |
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NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
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G |
Ifng |
interferon gamma |
multiple interactions |
ISO |
Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of CCL2 mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of CCL3 mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of CCL4 mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of CCR1 mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of CCR2 mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of CCR5 mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of HLA-DRA protein]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of TNFRSF4 mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of TNFRSF4 protein]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of TNFSF4 mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of TNFSF4 protein]] Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of CD40 mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of CD40 protein]] |
CTD |
PMID:11219190 PMID:16321392 PMID:17507688 PMID:19589242 |
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NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
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G |
Il12b |
interleukin 12B |
multiple interactions |
ISO |
Mevalonic Acid inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL12B protein] |
CTD |
PMID:15187114 |
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NCBI chr10:28,888,832...28,903,802
Ensembl chr10:28,893,008...28,902,903
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G |
Il17a |
interleukin 17A |
multiple interactions |
ISO |
Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of IL17A mRNA] |
CTD |
PMID:18453621 |
|
NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889
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G |
Il18 |
interleukin 18 |
multiple interactions |
EXP |
Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [Aldosterone results in increased expression of IL18 mRNA]] |
CTD |
PMID:18660453 |
|
NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
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G |
Il1a |
interleukin 1 alpha |
multiple interactions |
ISO EXP |
Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [[IL1A co-treated with PDGFB] results in increased secretion of MMP9 protein]] Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IL1A results in decreased expression of NOS2 protein]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IL1A results in increased abundance of Nitric Oxide]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IL1A results in increased localization of RELA protein]] |
CTD |
PMID:15705589 PMID:15728660 |
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NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
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G |
Il1b |
interleukin 1 beta |
multiple interactions |
ISO |
Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased secretion of IL1B protein]]; Mevalonic Acid inhibits the reaction [Simvastatin promotes the reaction [IL1B protein results in increased expression of ICAM1 protein]]; Mevalonic Acid inhibits the reaction [Simvastatin promotes the reaction [IL1B protein results in increased expression of SELE protein]] |
CTD |
PMID:10946302 PMID:17075836 |
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NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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G |
Il6 |
interleukin 6 |
multiple interactions |
ISO |
Mevalonic Acid inhibits the reaction [Atorvastatin inhibits the reaction [TNF results in increased expression of IL6 mRNA]]; Mevalonic Acid inhibits the reaction [Atorvastatin results in decreased expression of IL6 mRNA]; Mevalonic Acid inhibits the reaction [cerivastatin inhibits the reaction [TNF results in increased expression of IL6 mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IL6 results in increased expression of VEGFA mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IL6 results in increased expression of VEGFA protein]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased expression of IL6 mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased secretion of IL6 protein]]; Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of IL6 mRNA] Mevalonic Acid inhibits the reaction [Simvastatin promotes the reaction [[Lipopolysaccharides co-treated with TNF] results in increased expression of IL6 protein]] |
CTD |
PMID:12117737 PMID:16424782 PMID:16511915 PMID:17075836 PMID:17729120 |
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NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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G |
Irf4 |
interferon regulatory factor 4 |
multiple interactions |
ISO |
Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of IRF4 mRNA]; Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of IRF4 protein] |
CTD |
PMID:33034787 |
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NCBI chr17:33,721,800...33,742,570
Ensembl chr17:33,721,811...33,740,070
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G |
Itga2 |
integrin subunit alpha 2 |
multiple interactions |
EXP ISO |
Mevalonic Acid inhibits the reaction [Atorvastatin results in increased expression of [ITGA2 protein binds to ITGB1 protein]]; Mevalonic Acid inhibits the reaction [Pravastatin results in increased expression of [ITGA2 protein binds to ITGB1 protein]] |
CTD |
PMID:12500026 |
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NCBI chr 2:46,520,345...46,621,487
Ensembl chr 2:46,523,948...46,621,481
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G |
Itgb1 |
integrin subunit beta 1 |
multiple interactions |
EXP ISO |
Mevalonic Acid inhibits the reaction [Atorvastatin results in increased expression of [ITGA2 protein binds to ITGB1 protein]]; Mevalonic Acid inhibits the reaction [Pravastatin results in increased expression of [ITGA2 protein binds to ITGB1 protein]] Mevalonic Acid inhibits the reaction [Atorvastatin results in increased expression of [ITGA2 protein binds to ITGB1 protein]]; Mevalonic Acid inhibits the reaction [Atorvastatin results in increased expression of ITGB1 mRNA]; Mevalonic Acid inhibits the reaction [Pravastatin results in increased expression of [ITGA2 protein binds to ITGB1 protein]] |
CTD |
PMID:12500026 |
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NCBI chr19:56,705,123...56,753,199
Ensembl chr19:56,705,171...56,753,195
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G |
Jak1 |
Janus kinase 1 |
multiple interactions |
EXP |
Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [CTF1 results in increased expression of JAK1 protein]] |
CTD |
PMID:16534557 |
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NCBI chr 5:115,780,248...115,888,841
Ensembl chr 5:115,780,248...115,888,926
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G |
Jak2 |
Janus kinase 2 |
multiple interactions |
EXP |
Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [CTF1 results in increased expression of JAK2 protein]] |
CTD |
PMID:16534557 |
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NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189
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G |
Klf2 |
KLF transcription factor 2 |
multiple interactions |
ISO |
Mevalonic Acid inhibits the reaction [Simvastatin results in increased expression of KLF2 mRNA] |
CTD |
PMID:20493886 |
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NCBI chr16:17,521,107...17,523,739
Ensembl chr16:17,514,552...17,523,944
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G |
Lep |
leptin |
multiple interactions |
ISO |
Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of LEP mRNA]; Mevalonic Acid inhibits the reaction [Simvastatin results in decreased secretion of LEP protein] |
CTD |
PMID:19254925 |
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NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262
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G |
Mapk1 |
mitogen activated protein kinase 1 |
multiple interactions |
ISO EXP |
Mevalonic Acid inhibits the reaction [Atorvastatin results in decreased phosphorylation of MAPK1 protein] Mevalonic Acid inhibits the reaction [Atorvastatin results in increased phosphorylation of MAPK1 protein]; Mevalonic Acid inhibits the reaction [Lovastatin results in decreased phosphorylation of MAPK1 protein]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [Acrolein results in increased phosphorylation of MAPK1 protein]] |
CTD |
PMID:16470222 PMID:16952276 PMID:18339080 PMID:20359552 |
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NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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G |
Mapk3 |
mitogen activated protein kinase 3 |
multiple interactions |
EXP ISO |
Mevalonic Acid inhibits the reaction [Atorvastatin results in increased phosphorylation of MAPK3 protein]; Mevalonic Acid inhibits the reaction [Lovastatin results in decreased phosphorylation of MAPK3 protein]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [Acrolein results in increased phosphorylation of MAPK3 protein]] Mevalonic Acid inhibits the reaction [Atorvastatin results in decreased phosphorylation of MAPK3 protein] |
CTD |
PMID:16470222 PMID:16952276 PMID:18339080 PMID:20359552 |
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NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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G |
Mmp1 |
matrix metallopeptidase 1 |
multiple interactions |
ISO |
Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [Lipopolysaccharides results in increased secretion of MMP1 protein]]; Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of MMP1 mRNA]; Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of MMP1 protein]; Mevalonic Acid inhibits the reaction [Simvastatin results in decreased secretion of MMP1 protein] |
CTD |
PMID:17303772 PMID:18625914 |
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NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097
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G |
Mmp9 |
matrix metallopeptidase 9 |
multiple interactions |
ISO |
Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [[IL1A co-treated with PDGFB] results in increased secretion of MMP9 protein]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of MMP9 protein]] |
CTD |
PMID:15728660 |
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NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
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G |
Mstn |
myostatin |
multiple interactions |
ISO |
Mevalonic Acid inhibits the reaction [Simvastatin results in increased expression of MSTN mRNA]; Mevalonic Acid inhibits the reaction [Simvastatin results in increased expression of MSTN protein] |
CTD |
PMID:33034787 |
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NCBI chr 9:48,452,533...48,458,933
Ensembl chr 9:48,452,533...48,458,933
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G |
Mttp |
microsomal triglyceride transfer protein |
multiple interactions |
EXP |
Mevalonic Acid inhibits the reaction [Atorvastatin results in increased expression of MTTP mRNA] |
CTD |
PMID:12056585 |
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NCBI chr 2:226,613,090...226,654,239
Ensembl chr 2:226,613,090...226,654,239
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G |
Muc5ac |
mucin 5AC, oligomeric mucus/gel-forming |
multiple interactions |
ISO |
Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [Acrolein results in increased expression of MUC5AC protein]] |
CTD |
PMID:20359552 |
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NCBI chr 1:196,864,336...196,896,475
Ensembl chr 1:196,864,336...196,896,475
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G |
Mvk |
mevalonate kinase |
multiple interactions increases phosphorylation |
ISO |
3,3-dimethylallyl pyrophosphate inhibits the reaction [MVK protein results in increased phosphorylation of Mevalonic Acid]; dolichol monophosphate inhibits the reaction [MVK protein results in increased phosphorylation of Mevalonic Acid]; Farnesol inhibits the reaction [MVK protein results in increased phosphorylation of Mevalonic Acid]; farnesyl pyrophosphate inhibits the reaction [MVK protein results in increased phosphorylation of Mevalonic Acid]; geranyl diphosphate inhibits the reaction [MVK protein results in increased phosphorylation of Mevalonic Acid]; geranylgeranyl pyrophosphate inhibits the reaction [MVK protein results in increased phosphorylation of Mevalonic Acid]; isopentenyl pyrophosphate inhibits the reaction [MVK protein results in increased phosphorylation of Mevalonic Acid] |
CTD |
PMID:9392419 |
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NCBI chr12:42,141,391...42,158,893
Ensembl chr12:42,141,384...42,158,882
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G |
Nfe2l2 |
NFE2 like bZIP transcription factor 2 |
multiple interactions |
EXP |
Mevalonic Acid affects the reaction [Simvastatin results in increased localization of NFE2L2 protein] |
CTD |
PMID:18787804 |
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NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
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G |
Nfkb1 |
nuclear factor kappa B subunit 1 |
multiple interactions |
ISO |
Mevalonic Acid inhibits the reaction [Asbestos, Crocidolite affects the localization of NFKB1 protein]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]] |
CTD |
PMID:17277159 PMID:17322126 |
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NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
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G |
Nfkbia |
NFKB inhibitor alpha |
multiple interactions |
ISO |
Mevalonic Acid inhibits the reaction [Asbestos, Crocidolite results in decreased expression of and results in increased phosphorylation of NFKBIA protein]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased degradation of NFKBIA protein]] |
CTD |
PMID:17075836 PMID:17322126 |
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NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
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G |
Nos2 |
nitric oxide synthase 2 |
multiple interactions |
EXP ISO |
Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IL1A results in decreased expression of NOS2 protein]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [TNF results in decreased expression of NOS2 protein]] Mevalonic Acid inhibits the reaction [Simvastatin promotes the reaction [[Lipopolysaccharides co-treated with TNF] results in increased expression of NOS2 mRNA]] Mevalonic Acid inhibits the reaction [Fluvastatin results in increased expression of NOS2 protein] |
CTD |
PMID:15705589 PMID:17729120 PMID:24964743 |
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NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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G |
Nos3 |
nitric oxide synthase 3 |
multiple interactions |
ISO |
Mevalonic Acid inhibits the reaction [Simvastatin results in increased expression of NOS3 mRNA]; Mevalonic Acid inhibits the reaction [Y 27632 results in increased phosphorylation of NOS3 protein] |
CTD |
PMID:17322126 PMID:20493886 |
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NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
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G |
Nppa |
natriuretic peptide A |
multiple interactions |
EXP |
Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [CTF1 results in increased expression of NPPA mRNA]] |
CTD |
PMID:16534557 |
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NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351
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G |
Nr4a3 |
nuclear receptor subfamily 4, group A, member 3 |
multiple interactions |
ISO |
Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of NR4A3 mRNA] |
CTD |
PMID:16005304 |
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NCBI chr 5:62,361,588...62,401,489
Ensembl chr 5:62,361,822...62,402,733
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G |
Parp1 |
poly (ADP-ribose) polymerase 1 |
multiple interactions |
ISO |
Mevalonic Acid inhibits the reaction [Simvastatin promotes the reaction [TNFSF10 protein results in increased cleavage of PARP1 protein]]; Mevalonic Acid inhibits the reaction [Simvastatin results in increased cleavage of PARP1 protein]; Mevalonic Acid inhibits the reaction [TNFSF10 protein promotes the reaction [Simvastatin results in increased cleavage of PARP1 protein]] |
CTD |
PMID:20045437 PMID:21910007 |
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NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
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G |
Pcna |
proliferating cell nuclear antigen |
multiple interactions |
ISO |
Mevalonic Acid inhibits the reaction [Asbestos, Crocidolite results in increased expression of PCNA protein]; Mevalonic Acid inhibits the reaction [Clostridium difficile lethal toxin B results in increased expression of PCNA protein]; Mevalonic Acid inhibits the reaction [Y 27632 results in increased expression of PCNA protein] |
CTD |
PMID:17322126 |
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NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
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G |
Pcyt1a |
phosphate cytidylyltransferase 1A, choline |
increases activity increases expression |
EXP |
Mevalonic Acid results in increased activity of PCYT1A protein Mevalonic Acid results in increased expression of PCYT1A mRNA |
CTD |
PMID:12056585 |
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NCBI chr11:68,313,860...68,357,828
Ensembl chr11:68,313,882...68,357,357
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G |
Pdgfb |
platelet derived growth factor subunit B |
multiple interactions |
ISO |
Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [[IL1A co-treated with PDGFB] results in increased secretion of MMP9 protein]]; Mevalonic Acid inhibits the reaction [Simvastatin results in decreased activity of PDGFB protein] |
CTD |
PMID:8231022 PMID:15728660 |
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NCBI chr 7:111,539,444...111,557,984
Ensembl chr 7:111,540,345...111,557,984
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G |
Pdk4 |
pyruvate dehydrogenase kinase 4 |
multiple interactions |
EXP |
Mevalonic Acid inhibits the reaction [Atorvastatin inhibits the reaction [TNF protein results in decreased expression of PDK4 protein]] |
CTD |
PMID:22343369 |
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NCBI chr 4:33,591,796...33,601,798
Ensembl chr 4:33,589,799...33,601,850
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G |
Plat |
plasminogen activator, tissue type |
multiple interactions |
EXP ISO |
Mevalonic Acid inhibits the reaction [Lovastatin results in increased expression of PLAT protein] Mevalonic Acid inhibits the reaction [Simvastatin results in increased expression of PLAT mRNA]; Mevalonic Acid inhibits the reaction [Simvastatin results in increased expression of PLAT] |
CTD |
PMID:10412747 PMID:12371961 PMID:12753293 |
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NCBI chr16:69,240,582...69,265,177
Ensembl chr16:69,240,585...69,268,223
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G |
Pon1 |
paraoxonase 1 |
multiple interactions |
ISO |
Mevalonic Acid inhibits the reaction [pitavastatin results in increased expression of PON1 mRNA]; Mevalonic Acid inhibits the reaction [Simvastatin promotes the reaction [SREBF2 protein binds to PON1 promoter]]; Mevalonic Acid inhibits the reaction [Simvastatin results in increased expression of PON1 mRNA] |
CTD |
PMID:14500290 PMID:15690306 |
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NCBI chr 4:33,294,737...33,325,759
Ensembl chr 4:33,294,722...33,321,360
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G |
Ppara |
peroxisome proliferator activated receptor alpha |
multiple interactions |
ISO |
Mevalonic Acid inhibits the reaction [cerivastatin promotes the reaction [Bezafibrate results in increased activity of [PPARA protein binds to RXRA protein]]] |
CTD |
PMID:11779144 |
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NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
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G |
Pparg |
peroxisome proliferator-activated receptor gamma |
multiple interactions |
EXP |
Mevalonic Acid inhibits the reaction [Lovastatin results in increased expression of PPARG mRNA] |
CTD |
PMID:20578043 |
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NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
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G |
Prkcd |
protein kinase C, delta |
multiple interactions |
EXP |
Mevalonic Acid inhibits the reaction [Lovastatin results in increased cleavage of PRKCD protein] |
CTD |
PMID:16367743 |
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NCBI chr16:5,769,217...5,799,380
Ensembl chr16:5,769,215...5,799,352
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G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
multiple interactions |
ISO |
Mevalonic Acid affects the reaction [Lovastatin analog results in increased expression of PTGS2 protein]; Mevalonic Acid inhibits the reaction [Simvastatin promotes the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA]] |
CTD |
PMID:18612546 PMID:26863638 |
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NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
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G |
Pxn |
paxillin |
multiple interactions |
EXP |
Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [AGT protein results in increased phosphorylation of PXN protein]] |
CTD |
PMID:22306966 |
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NCBI chr12:41,060,791...41,107,952
Ensembl chr12:41,060,791...41,107,931
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G |
Rac1 |
Rac family small GTPase 1 |
multiple interactions |
ISO EXP |
Mevalonic Acid inhibits the reaction [Lovastatin affects the localization of RAC1 protein] Mevalonic Acid inhibits the reaction [Simvastatin results in increased expression of RAC1 protein] |
CTD |
PMID:12933658 PMID:16698853 |
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NCBI chr12:11,037,028...11,057,251
Ensembl chr12:11,036,698...11,057,251
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G |
Rap1a |
RAP1A, member of RAS oncogene family |
multiple interactions |
ISO |
Mevalonic Acid affects the reaction [Menthol analog results in increased expression of RAP1A protein]; Mevalonic Acid affects the reaction [Menthol results in increased expression of RAP1A protein]; Mevalonic Acid affects the reaction [myrtenol results in increased expression of RAP1A protein]; Mevalonic Acid affects the reaction [perillaldehyde results in increased expression of RAP1A protein]; Mevalonic Acid affects the reaction [perillyl alcohol results in increased expression of RAP1A protein]; Mevalonic Acid inhibits the reaction [cerivastatin results in decreased geranoylation of RAP1A protein]; Mevalonic Acid inhibits the reaction [Simvastatin results in decreased geranoylation of RAP1A protein] |
CTD |
PMID:12671036 PMID:25578243 |
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NCBI chr 2:193,208,631...193,286,513
Ensembl chr 2:193,208,635...193,286,501
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G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions |
EXP ISO |
Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IL1A results in increased localization of RELA protein]] Mevalonic Acid inhibits the reaction [Asbestos, Crocidolite affects the localization of RELA protein]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]] |
CTD |
PMID:15705589 PMID:17277159 PMID:17322126 |
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NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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G |
Retn |
resistin |
multiple interactions |
ISO |
Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [CRP results in increased expression of RETN mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [CRP results in increased secretion of RETN protein]] |
CTD |
PMID:18023360 |
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NCBI chr12:1,710,881...1,712,621
Ensembl chr12:1,710,881...1,712,620
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G |
Rhoa |
ras homolog family member A |
multiple interactions |
ISO EXP |
Mevalonic Acid affects the reaction [2-methyl-5-(1-methylethenyl)cyclohexanol results in increased expression of RHOA protein]; Mevalonic Acid affects the reaction [carvone results in increased expression of RHOA protein]; Mevalonic Acid affects the reaction [Menthol analog results in increased expression of RHOA protein]; Mevalonic Acid affects the reaction [myrtenol results in increased expression of RHOA protein]; Mevalonic Acid affects the reaction [perillaldehyde results in increased expression of RHOA protein]; Mevalonic Acid affects the reaction [perillic acid results in increased expression of RHOA protein]; Mevalonic Acid affects the reaction [perillyl alcohol results in increased expression of RHOA protein]; Mevalonic Acid inhibits the reaction [Asbestos, Crocidolite results in decreased activity of and results in decreased lipidation of RHOA protein]; Mevalonic Acid inhibits the reaction [Atorvastatin results in decreased activity of RHOA protein]; Mevalonic Acid inhibits the reaction [Atorvastatin results in increased localization of RHOA protein]; Mevalonic Acid inhibits the reaction [Lovastatin affects the localization of RHOA protein]; Mevalonic Acid inhibits the reaction [mevastatin results in decreased lipidation of RHOA protein]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased activity of RHOA protein]]; Mevalonic Acid inhibits the reaction [Simvastatin results in decreased activity of RHOA protein]; Mevalonic Acid inhibits the reaction [Simvastatin results in decreased geranoylation of and affects the localization of RHOA protein]; Mevalonic Acid inhibits the reaction [Simvastatin results in increased localization of RHOA protein] Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of RHOA protein] |
CTD |
PMID:12477733 PMID:12671036 PMID:12933658 PMID:16005304 PMID:16470222 PMID:16698853 PMID:17075836 PMID:17322126 More...
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NCBI chr 8:108,991,926...109,025,746
Ensembl chr 8:108,991,954...109,025,746
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G |
Rhob |
ras homolog family member B |
multiple interactions |
ISO |
Mevalonic Acid affects the reaction [2-methyl-5-(1-methylethenyl)cyclohexanol results in increased expression of RHOB protein]; Mevalonic Acid affects the reaction [carveol results in increased expression of RHOB protein]; Mevalonic Acid affects the reaction [carvone results in increased expression of RHOB protein]; Mevalonic Acid affects the reaction [Menthol analog results in increased expression of RHOB protein]; Mevalonic Acid affects the reaction [Menthol results in increased expression of RHOB protein]; Mevalonic Acid affects the reaction [myrtenol results in increased expression of RHOB protein]; Mevalonic Acid affects the reaction [perillaldehyde results in increased expression of RHOB protein]; Mevalonic Acid affects the reaction [perillic acid results in increased expression of RHOB protein]; Mevalonic Acid affects the reaction [perillyl alcohol results in increased expression of RHOB protein] |
CTD |
PMID:12671036 |
|
NCBI chr 6:31,363,752...31,365,926
Ensembl chr 6:31,363,548...31,366,108
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G |
Rorc |
RAR-related orphan receptor C |
multiple interactions |
ISO |
Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of RORC mRNA] |
CTD |
PMID:18453621 |
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NCBI chr 2:182,009,707...182,034,910
Ensembl chr 2:182,009,286...182,034,907
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G |
RT1-Da |
RT1 class II, locus Da |
multiple interactions |
ISO |
Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of HLA-DRA protein]] |
CTD |
PMID:11219190 |
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NCBI chr20:4,513,464...4,518,457
Ensembl chr20:4,512,911...4,518,455
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G |
Rxra |
retinoid X receptor alpha |
multiple interactions |
ISO |
Mevalonic Acid inhibits the reaction [cerivastatin promotes the reaction [Bezafibrate results in increased activity of [PPARA protein binds to RXRA protein]]] |
CTD |
PMID:11779144 |
|
NCBI chr 3:10,989,832...11,076,366
Ensembl chr 3:10,989,832...11,073,712
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G |
Sele |
selectin E |
multiple interactions |
ISO |
Mevalonic Acid inhibits the reaction [Simvastatin promotes the reaction [IL1B protein results in increased expression of SELE protein]] |
CTD |
PMID:10946302 |
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NCBI chr13:76,402,841...76,412,741
Ensembl chr13:76,403,304...76,412,741
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G |
Sod2 |
superoxide dismutase 2 |
multiple interactions |
ISO |
Mevalonic Acid inhibits the reaction [Fluvastatin results in increased expression of SOD2 protein] |
CTD |
PMID:24964743 |
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NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
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G |
Srebf2 |
sterol regulatory element binding transcription factor 2 |
multiple interactions |
EXP ISO |
Mevalonic Acid inhibits the reaction [Atorvastatin results in increased expression of SREBF2 mRNA]; Mevalonic Acid inhibits the reaction [Simvastatin results in increased expression of SREBF2 mRNA] Mevalonic Acid inhibits the reaction [Simvastatin promotes the reaction [SREBF2 protein binds to PON1 promoter]] |
CTD |
PMID:12056585 PMID:14500290 |
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NCBI chr 7:113,663,202...113,720,850
Ensembl chr 7:113,663,202...113,720,848
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G |
Stat1 |
signal transducer and activator of transcription 1 |
multiple interactions increases expression |
ISO EXP |
Mevalonic Acid inhibits the reaction [Simvastatin results in decreased phosphorylation of STAT1 protein] Mevalonic Acid results in increased expression of STAT1 protein Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [CTF1 results in increased expression of STAT1 protein]] Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of STAT1 mRNA]; Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of STAT1 protein] |
CTD |
PMID:16534557 PMID:17507688 PMID:18453621 |
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NCBI chr 9:49,419,561...49,459,969
Ensembl chr 9:49,419,340...49,588,540
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G |
Stat3 |
signal transducer and activator of transcription 3 |
multiple interactions |
EXP ISO |
Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [CTF1 results in increased expression of STAT3 protein]] Mevalonic Acid inhibits the reaction [Simvastatin results in decreased phosphorylation of STAT3 protein] |
CTD |
PMID:16534557 PMID:18453621 |
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NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
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G |
Tfrc |
transferrin receptor |
multiple interactions |
ISO |
Mevalonic Acid inhibits the reaction [Fluvastatin results in decreased expression of TFRC mRNA]; Mevalonic Acid inhibits the reaction [Fluvastatin results in decreased expression of TFRC protein] |
CTD |
PMID:24964743 |
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NCBI chr11:68,163,413...68,185,257
Ensembl chr11:68,163,413...68,185,257
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G |
Th |
tyrosine hydroxylase |
multiple interactions |
ISO |
Mevalonic Acid inhibits the reaction [Lovastatin results in increased expression of TH protein] |
CTD |
PMID:20694854 |
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NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767
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G |
Thbd |
thrombomodulin |
multiple interactions |
ISO |
Mevalonic Acid inhibits the reaction [Simvastatin results in increased expression of THBD mRNA] |
CTD |
PMID:20493886 |
|
NCBI chr 3:135,863,366...135,867,018
Ensembl chr 3:135,862,835...135,867,193
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G |
Tnf |
tumor necrosis factor |
multiple interactions |
ISO EXP |
Mevalonic Acid inhibits the reaction [Atorvastatin inhibits the reaction [TNF results in increased expression of CCL2 mRNA]]; Mevalonic Acid inhibits the reaction [Atorvastatin inhibits the reaction [TNF results in increased expression of CXCL8 mRNA]]; Mevalonic Acid inhibits the reaction [Atorvastatin inhibits the reaction [TNF results in increased expression of IL6 mRNA]]; Mevalonic Acid inhibits the reaction [cerivastatin inhibits the reaction [TNF results in increased expression of CCL2 mRNA]]; Mevalonic Acid inhibits the reaction [cerivastatin inhibits the reaction [TNF results in increased expression of CXCL8 mRNA]]; Mevalonic Acid inhibits the reaction [cerivastatin inhibits the reaction [TNF results in increased expression of IL6 mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased activity of RHOA protein]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased degradation of NFKBIA protein]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased expression of CCL2 mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased expression of CCL4 mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased expression of CCR4 mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased expression of CXCL8 mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased expression of ICAM1 mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased expression of IL6 mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased expression of VCAM1 mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased secretion of IL1B protein]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased secretion of IL6 protein]] Mevalonic Acid inhibits the reaction [Atorvastatin inhibits the reaction [TNF protein results in decreased expression of PDK4 protein]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [Acrolein results in increased secretion of TNF protein]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [TNF results in decreased expression of NOS2 protein]] Mevalonic Acid inhibits the reaction [Simvastatin promotes the reaction [[Lipopolysaccharides co-treated with TNF] results in increased abundance of Nitric Oxide]]; Mevalonic Acid inhibits the reaction [Simvastatin promotes the reaction [[Lipopolysaccharides co-treated with TNF] results in increased expression of IL6 protein]]; Mevalonic Acid inhibits the reaction [Simvastatin promotes the reaction [[Lipopolysaccharides co-treated with TNF] results in increased expression of NOS2 mRNA]] |
CTD |
PMID:12117737 PMID:15705589 PMID:16321392 PMID:16511915 PMID:17075836 PMID:17277159 PMID:17729120 PMID:20359552 PMID:20863785 PMID:22343369 More...
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NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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G |
Tnfrsf4 |
TNF receptor superfamily member 4 |
multiple interactions |
ISO |
Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of TNFRSF4 mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of TNFRSF4 protein]] |
CTD |
PMID:19589242 |
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NCBI chr 5:166,606,909...166,609,599
Ensembl chr 5:166,606,909...166,609,599
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G |
Tnfsf10 |
TNF superfamily member 10 |
multiple interactions |
ISO |
Mevalonic Acid inhibits the reaction [Simvastatin promotes the reaction [TNFSF10 protein results in increased cleavage of PARP1 protein]]; Mevalonic Acid inhibits the reaction [TNFSF10 protein promotes the reaction [Simvastatin results in increased cleavage of PARP1 protein]] |
CTD |
PMID:21910007 |
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NCBI chr 2:110,199,835...110,227,239
Ensembl chr 2:110,207,916...110,225,135
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G |
Tnfsf4 |
TNF superfamily member 4 |
multiple interactions |
ISO |
Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of TNFSF4 mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of TNFSF4 protein]] |
CTD |
PMID:19589242 |
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NCBI chr13:73,723,329...73,746,809
Ensembl chr13:73,723,329...73,746,788
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G |
Vcam1 |
vascular cell adhesion molecule 1 |
multiple interactions |
ISO |
Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [CD40LG results in increased expression of VCAM1 mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased expression of VCAM1 mRNA]] |
CTD |
PMID:18269829 PMID:20863785 |
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NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958
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G |
Vegfa |
vascular endothelial growth factor A |
multiple interactions |
ISO |
Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IL6 results in increased expression of VEGFA mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IL6 results in increased expression of VEGFA protein]]; Mevalonic Acid inhibits the reaction [Simvastatin results in increased expression of VEGFA mRNA] |
CTD |
PMID:16424782 PMID:18356691 |
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NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
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G |
Hmgcr |
3-hydroxy-3-methylglutaryl-CoA reductase |
decreases activity |
ISO |
mevalonolactone results in decreased activity of HMGCR protein |
CTD |
PMID:3042028 PMID:12477733 |
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NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703
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G |
Ptgir |
prostaglandin I2 receptor |
affects binding |
ISO |
mevalonolactone binds to PTGIR protein |
CTD |
PMID:11895442 |
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NCBI chr 1:77,579,596...77,581,979
Ensembl chr 1:77,579,596...77,581,979
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G |
Rap2a |
RAP2A, member of RAS oncogene family |
increases farnesylation |
ISO |
mevalonolactone results in increased farnesylation of RAP2A protein |
CTD |
PMID:8424780 |
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NCBI chr15:97,596,848...97,597,338
Ensembl chr15:97,596,020...97,624,138
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G |
Rap2b |
RAP2B, member of RAS oncogene family |
increases prenylation |
ISO |
mevalonolactone results in increased prenylation of RAP2B protein |
CTD |
PMID:8424780 |
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NCBI chr 2:145,599,714...145,600,265
Ensembl chr 2:145,599,116...145,603,069
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