Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:methyladenosine
go back to main search page
Accession:CHEBI:25273 term browser browse the term
Definition:A hydrocarbyladenosine that has formula C11H15N5O4.


show annotations for term's descendants           Sort by:
N(6)-methyladenosine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fto FTO, alpha-ketoglutarate dependent dioxygenase multiple interactions ISO [FTO results in decreased abundance of N-methyladenosine] which results in decreased methylation of SETD2 mRNA alternative form CTD PMID:36260529 NCBI chr19:15,284,898...15,692,142
Ensembl chr19:15,349,696...15,692,083 		JBrowse link
G Igfbp4 insulin-like growth factor binding protein 4 multiple interactions ISO [[METTL3 protein affects the abundance of N-methyladenosine] which affects the methylation of IGFBP4 mRNA] which affects the expression of IGFBP4 protein; [METTL3 protein affects the abundance of N-methyladenosine] which affects the expression of IGFBP4 protein; [METTL3 protein affects the abundance of N-methyladenosine] which affects the methylation of IGFBP4 mRNA CTD PMID:35971034 NCBI chr10:83,995,253...84,007,272
Ensembl chr10:83,989,591...84,007,225 		JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member multiple interactions EXP METTL3 inhibits the reaction [N-methyladenosine results in decreased expression of MCL1 mRNA] CTD PMID:36260529 NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303 		JBrowse link
G Mettl3 methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit affects abundance
multiple interactions		 ISO
EXP		 METTL3 protein affects the abundance of N-methyladenosine
[[METTL3 protein affects the abundance of N-methyladenosine] which affects the methylation of IGFBP4 mRNA] which affects the expression of IGFBP4 protein; [[METTL3 protein affects the abundance of N-methyladenosine] which affects the methylation of PAPPA mRNA] which affects the expression of PAPPA protein; [METTL3 protein affects the abundance of N-methyladenosine] which affects the expression of IGFBP4 protein; [METTL3 protein affects the abundance of N-methyladenosine] which affects the expression of PAPPA protein; [METTL3 protein affects the abundance of N-methyladenosine] which affects the methylation of IGFBP4 mRNA; [METTL3 protein affects the abundance of N-methyladenosine] which affects the methylation of PAPPA mRNA; [METTL3 results in increased abundance of N-methyladenosine] which results in increased methylation of SETD2 mRNA alternative form
METTL3 inhibits the reaction [N-methyladenosine results in decreased expression of MCL1 mRNA]; METTL3 inhibits the reaction [N-methyladenosine results in decreased expression of SETD2 mRNA alternative form]		 CTD PMID:35971034 PMID:36260529 NCBI chr15:25,002,505...25,014,097
Ensembl chr15:25,003,172...25,014,041 		JBrowse link
G Mir145 microRNA 145 increases abundance
multiple interactions		 ISO MIR145 mRNA results in increased abundance of N-methyladenosine
[MIR145 mRNA results in decreased expression of YTHDF2 protein] which results in increased abundance of N-methyladenosine; YTHDF2 protein inhibits the reaction [MIR145 mRNA results in increased abundance of N-methyladenosine]		 CTD PMID:28104805 NCBI chr18:55,099,640...55,099,727
Ensembl chr18:55,099,640...55,099,727 		JBrowse link
G Pappa pappalysin multiple interactions ISO [[METTL3 protein affects the abundance of N-methyladenosine] which affects the methylation of PAPPA mRNA] which affects the expression of PAPPA protein; [METTL3 protein affects the abundance of N-methyladenosine] which affects the expression of PAPPA protein; [METTL3 protein affects the abundance of N-methyladenosine] which affects the methylation of PAPPA mRNA CTD PMID:35971034 NCBI chr 5:78,497,660...78,735,873
Ensembl chr 5:78,498,300...78,730,666 		JBrowse link
G Setd2 SET domain containing 2, histone lysine methyltransferase multiple interactions EXP
ISO		 METTL3 inhibits the reaction [N-methyladenosine results in decreased expression of SETD2 mRNA alternative form]
[FTO results in decreased abundance of N-methyladenosine] which results in decreased methylation of SETD2 mRNA alternative form; [METTL3 results in increased abundance of N-methyladenosine] which results in increased methylation of SETD2 mRNA alternative form		 CTD PMID:36260529 NCBI chr 8:110,511,808...110,597,475
Ensembl chr 8:110,511,772...110,597,489 		JBrowse link
G Ythdf2 YTH N6-methyladenosine RNA binding protein F2 multiple interactions
affects binding		 ISO [MIR145 mRNA results in decreased expression of YTHDF2 protein] which results in increased abundance of N-methyladenosine; YTHDF2 protein inhibits the reaction [MIR145 mRNA results in increased abundance of N-methyladenosine]
YTHDF2 protein binds to N-methyladenosine		 CTD PMID:28104805 PMID:34213887 NCBI chr 5:144,381,426...144,407,126
Ensembl chr 5:144,381,431...144,408,144 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19811
    role 19818
      biological role 19785
        biochemical role 19496
          metabolite 19484
            fundamental metabolite 14418
              purine 6859
                9H-purine 6681
                  adenine 1014
                    adenosines 765
                      hydrocarbyladenosine 10
                        methyladenosine 8
                          1-methyladenosine 0
                          2-methyladenosine 0
                          N(6),2'-O-dimethyladenosine 0
                          N(6)-methyladenosine 8
Path 2
Term Annotations click to browse term
  CHEBI ontology 19811
    subatomic particle 19809
      composite particle 19809
        hadron 19840
          baryon 19809
            nucleon 19809
              atomic nucleus 19809
                atom 19809
                  main group element atom 19759
                    p-block element atom 19759
                      carbon group element atom 19708
                        carbon atom 19734
                          organic molecular entity 19705
                            heteroorganic entity 19459
                              organochalcogen compound 19222
                                organooxygen compound 19137
                                  carbohydrates and carbohydrate derivatives 15269
                                    carbohydrate 15284
                                      carbohydrate derivative 14290
                                        glycosyl compound 13035
                                          N-glycosyl compound 5808
                                            nucleoside 5662
                                              ribonucleoside 1121
                                                purine ribonucleoside 785
                                                  adenosines 765
                                                    hydrocarbyladenosine 10
                                                      methyladenosine 8
                                                        1-methyladenosine 0
                                                        2-methyladenosine 0
                                                        N(6),2'-O-dimethyladenosine 0
                                                        N(6)-methyladenosine 8
paths to the root