Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:ajmalicine
go back to main search page
Accession:CHEBI:2524 term browser browse the term
Definition:A monoterpenoid indole alkaloid with formula C21H24N2O3, isolated from several Rauvolfia and Catharanthus species. It is a selective alpha1-adrenoceptor antagonist used for the treatment of high blood pressure.
Synonyms:exact_synonym: methyl (19alpha)-19-methyl-16,17-didehydro-18-oxayohimban-16-carboxylate
 related_synonym: (19alpha)-16,17-didehydro-19-methyl-oxayohimban-16-carboxylic acid methyl ester;   Circolene;   Cristanyl;   Duxil;   Formula=C21H24N2O3;   InChI=1S/C21H24N2O3/c1-12-16-10-23-8-7-14-13-5-3-4-6-18(13)22-20(14)19(23)9-15(16)17(11-26-12)21(24)25-2/h3-6,11-12,15-16,19,22H,7-10H2,1-2H3/t12-,15-,16+,19-/m0/s1;   InChIKey=GRTOGORTSDXSFK-XJTZBENFSA-N;   Lamuran;   Raubasine;   SMILES=C=1C=CC=2NC=3[C@]4(N(CCC3C2C1)C[C@]5([C@@](C(=CO[C@H]5C)C(OC)=O)(C4)[H])[H])[H];   Sarpan;   ajmalicin;   delta-yohimbine;   methyl (4S,4aR,13bS,14aS)-4-methyl-4a,5,7,8,13,13b,14,14a-octahydro-4H-indolo[2,3-a]pyrano[3,4-g]quinolizine-1-carboxylate
 xref: CAS:483-04-5;   KEGG:C09024;   KEGG:D08470;   KNApSAcK:C00001678;   LINCS:LSM-15373
 xref_mesh: MESH:C005709
 xref: PMID:15930738;   PMID:19151732;   PMID:22331368;   PMID:22332772;   PMID:24237015;   PMID:26983347;   PMID:27584856;   PMID:4387608;   PMID:6091834;   PMID:6128043;   Reaxys:97268;   Wikipedia:Ajmalicine
 cyclic_relationship: is_conjugate_base_of CHEBI:142527


show annotations for term's descendants           Sort by:
 
ajmalicine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 decreases activity
multiple interactions
ISO raubasine results in decreased activity of CYP2D6 protein
raubasine inhibits the reaction [CYP2D6 protein affects the metabolism of Dextromethorphan]
CTD PMID:15930738 NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    role 19732
      application 19391
        fuel 10797
          methanol 3062
            methyl ester 3051
              ajmalicine 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    p-block element atom 19670
                      chalcogen 19360
                        oxygen atom 19321
                          oxygen molecular entity 19321
                            hydroxides 19066
                              organic hydroxy compound 18630
                                alcohol 14984
                                  aliphatic alcohol 11104
                                    alkyl alcohol 11058
                                      methanol 3062
                                        methyl ester 3051
                                          ajmalicine 1
paths to the root

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.