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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:methoxybenzoic acid
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Accession:CHEBI:25238 term browser browse the term
Definition:Any benzoic acid carrying one or more methoxy substituents.
Synonyms:related_synonym: methoxybenzoic acids



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3,4-dimethoxybenzoic acid 4-[ethyl-[1-(4-methoxyphenyl)propan-2-yl]amino]butyl ester term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO mebeverine results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO mebeverine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
JBrowse link
dicamba term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acox1 acyl-CoA oxidase 1 increases activity EXP Dicamba results in increased activity of ACOX1 protein CTD PMID:7657066 NCBI chr10:101,406,197...101,431,242
Ensembl chr10:101,406,197...101,431,232
JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing multiple interactions ISO Dicamba inhibits the reaction [[Dexamethasone co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of and results in increased secretion of ADIPOQ protein] CTD PMID:29782964 NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564
JBrowse link
G Alb albumin multiple interactions EXP [bentazone co-treated with Dicamba] results in increased secretion of ALB protein CTD PMID:25863332 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
JBrowse link
G Ins2 insulin 2 multiple interactions ISO Dicamba inhibits the reaction [[Dexamethasone co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of and results in increased secretion of ADIPOQ protein] CTD PMID:29782964 NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775
JBrowse link
G Srxn1 sulfiredoxin 1 increases expression ISO Dicamba results in increased expression of SRXN1 mRNA CTD PMID:34626751 NCBI chr 3:140,604,490...140,610,050
Ensembl chr 3:140,599,608...140,628,448
JBrowse link
eluxadoline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Oprd1 opioid receptor, delta 1 affects response to substance ISO OPRD1 protein affects the susceptibility to eluxadoline CTD PMID:25261794 NCBI chr 5:144,306,188...144,340,960
Ensembl chr 5:144,306,188...144,340,960
JBrowse link
O-methylsalicylic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
decreases activity
ISO 2-methoxybenzoic acid inhibits the reaction [PTGS2 protein results in increased metabolism of Arachidonic Acid]
2-methoxybenzoic acid results in decreased activity of PTGS2 protein
CTD PMID:12538810 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
vanillic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bad BCL2-associated agonist of cell death multiple interactions ISO Vanillic Acid inhibits the reaction [INS protein results in decreased expression of BAD protein] CTD PMID:33651899 NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823
JBrowse link
G Casp3 caspase 3 multiple interactions EXP Vanillic Acid inhibits the reaction [Isoproterenol results in increased expression of CASP3 mRNA] CTD PMID:25794854 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp8 caspase 8 multiple interactions EXP Vanillic Acid inhibits the reaction [Isoproterenol results in increased expression of CASP8 mRNA] CTD PMID:25794854 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Casp9 caspase 9 multiple interactions EXP Vanillic Acid inhibits the reaction [Isoproterenol results in increased expression of CASP9 mRNA] CTD PMID:25794854 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Fas Fas cell surface death receptor multiple interactions EXP Vanillic Acid inhibits the reaction [Isoproterenol results in increased expression of FAS mRNA] CTD PMID:25794854 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
JBrowse link
G G6pc1 glucose-6-phosphatase catalytic subunit 1 multiple interactions ISO Vanillic Acid inhibits the reaction [INS protein results in increased expression of G6PC1 protein] CTD PMID:33651899 NCBI chr10:86,307,400...86,318,766
Ensembl chr10:86,257,668...86,333,804
JBrowse link
G Gck glucokinase multiple interactions ISO Vanillic Acid inhibits the reaction [INS protein results in decreased activity of GCK protein]; Vanillic Acid inhibits the reaction [INS protein results in decreased expression of GCK protein] CTD PMID:33651899 NCBI chr14:80,785,060...80,829,842
Ensembl chr14:80,785,060...80,826,995
JBrowse link
G Gckr glucokinase regulator multiple interactions ISO Vanillic Acid inhibits the reaction [INS protein results in increased expression of GCKR protein] CTD PMID:33651899 NCBI chr 6:25,044,592...25,075,834
Ensembl chr 6:25,045,100...25,075,654
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions ISO Vanillic Acid inhibits the reaction [INS protein results in increased expression of GSK3B protein] CTD PMID:33651899 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
JBrowse link
G Gys1 glycogen synthase 1 multiple interactions ISO Vanillic Acid inhibits the reaction [INS protein results in decreased expression of GYS1 protein] CTD PMID:33651899 NCBI chr 1:95,915,443...95,935,292
Ensembl chr 1:95,915,443...95,935,292
JBrowse link
G Ins2 insulin 2 multiple interactions ISO Vanillic Acid inhibits the reaction [INS protein results in decreased activity of GCK protein]; Vanillic Acid inhibits the reaction [INS protein results in decreased expression of BAD protein]; Vanillic Acid inhibits the reaction [INS protein results in decreased expression of GCK protein]; Vanillic Acid inhibits the reaction [INS protein results in decreased expression of GYS1 protein]; Vanillic Acid inhibits the reaction [INS protein results in increased expression of G6PC1 protein]; Vanillic Acid inhibits the reaction [INS protein results in increased expression of GCKR protein]; Vanillic Acid inhibits the reaction [INS protein results in increased expression of GSK3B protein] CTD PMID:33651899 NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775
JBrowse link
G LOC686683 similar to olfactory receptor 73 multiple interactions ISO Vanillic Acid analog binds to and results in increased activity of OR5D18 protein CTD PMID:21142015 NCBI chr 3:73,516,522...73,517,463
Ensembl chr 3:73,516,364...73,519,858
Ensembl chr 3:73,516,364...73,519,858
JBrowse link
G Mir122 microRNA 122 decreases expression ISO Vanillic Acid results in decreased expression of MIR122 mRNA CTD PMID:24165878 NCBI chr18:58,758,703...58,758,787 JBrowse link
G Nos3 nitric oxide synthase 3 increases expression ISO Vanillic Acid results in increased expression of NOS3 mRNA CTD PMID:15740983 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 increases glucuronidation ISO UGT1A3 protein results in increased glucuronidation of Vanillic Acid CTD PMID:15117964 NCBI chr 9:88,791,216...88,808,465
Ensembl chr 9:88,713,184...88,808,465
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20072
    role 20026
      chemical role 19582
        donor 18906
          Bronsted acid 18792
            oxoacid 18753
              carbon oxoacid 18633
                carboxylic acid 18629
                  aromatic carboxylic acid 11814
                    benzoic acids 11789
                      methoxybenzoic acid 23
                        2,4,5-Trimethoxybenzoic acid 0
                        2,6-dimethoxybenzoic acid [[amino(pyridin-4-yl)methylidene]amino] ester 0
                        2-Amino-5-methoxybenzoic acid 0
                        2-HYDROXY-3,4-DIMETHOXYBENZOIC ACID 0
                        2-Methoxy-4-pentadecylbenzoic acid 0
                        2-[(carboxymethyl)(methyl)amino]-5-methoxybenzoic acid 0
                        2-[[anilino(oxo)methyl]amino]-4,5-dimethoxybenzoic acid 0
                        2-hydroxy-3-methoxybenzoic acid [2-[2-chloro-5-[ethyl(phenyl)sulfamoyl]anilino]-2-oxoethyl] ester 0
                        2-hydroxy-4-methoxy-6-methylbenzoic acid ethyl ester 0
                        2-hydroxy-4-methoxy-6-methylbenzoic acid methyl ester 0
                        2-hydroxy-4-methoxybenzoic acid (2-methyl-4-thiazolyl)methyl ester 0
                        2-methoxy-4-(methylthio)benzoic acid [2-(cyclopropylamino)-2-oxoethyl] ester 0
                        2-methoxybenzoic acid 4-[[5-(1-naphthalenyl)-1,3,4-oxadiazol-2-yl]thio]but-2-ynyl ester 0
                        3,4-Dimethoxy-1,2-benzenedicarboxylic acid 0
                        3,4-dimethoxybenzoic acid 4-[ethyl-[1-(4-methoxyphenyl)propan-2-yl]amino]butyl ester 2
                        3,4-dimethoxybenzoic acid [(1R,5R)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl] ester 0
                        3,5-dimethoxybenzoic acid + 0
                        3-chloro-2,6-dimethoxybenzoic acid 0
                        3-decaprenyl-4-hydroxy-5-methoxybenzoic acid 0
                        3-hexaprenyl-4-hydroxy-5-methoxybenzoic acid 0
                        3-hydroxy-4-methoxybenzoic acid + 0
                        3-methoxy-4-hydroxy-5-all-trans-polyprenylbenzoic acid + 0
                        3-methoxybenzoic acid 0
                        3-methoxybenzoic acid [[1-amino-2-(4-chlorophenyl)ethylidene]amino] ester 0
                        3-methoxybenzoic acid [[amino-(4-nitrophenyl)methylidene]amino] ester 0
                        3-nonaprenyl-4-hydroxy-5-methoxybenzoic acid 0
                        4,5-Dimethoxy-1,2-benzenedicarboxylic acid 0
                        4,5-dimethoxy-2-[[(2-methoxyanilino)-oxomethyl]amino]benzoic acid methyl ester 0
                        4-Hydroxy-7-methoxy-1,3-benzodioxole-5-carboxylic acid 0
                        4-O-methylolivetolcarboxylic acid 0
                        4-[2-(5-Carboxy-2-hydroxy-3-methoxyphenyl)-2-oxoethylidene]-2-hydroxy-2-pentenedioate 0
                        4-[2-[(2,6-dimethoxyphenyl)-oxomethoxy]-1-oxoethyl]-2,5-dimethyl-1H-pyrrole-3-carboxylic acid ethyl ester 0
                        4-acetyloxy-3-methoxybenzoic acid (4,7,7-trimethyl-3-bicyclo[2.2.1]heptanyl) ester 0
                        4-amino-5-chloro-2-methoxybenzoic acid 2-(diethylamino)ethyl ester 0
                        4-amino-5-chloro-2-methoxybenzoic acid 3-(1-piperidinyl)propyl ester 0
                        4-hydroxy-3-methoxybenzoic acid [(1S,5R)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl] ester 0
                        4-methoxy-3-(sulfooxy)benzoic acid 0
                        4-methoxy-3-[2-phenylethyl-(phenylmethyl)sulfamoyl]benzoic acid 0
                        4-methoxybenzoic acid + 0
                        4-methoxybenzoic acid 2-(4-hydroxyphenyl)ethyl ester 0
                        4-methoxybenzoic acid 4-[[5-(1-naphthalenyl)-1,3,4-oxadiazol-2-yl]thio]but-2-ynyl ester 0
                        4-methoxybenzoic acid [1-(2-pyrazinyl)ethylideneamino] ester 0
                        4-methoxybenzoic acid [1-(2-thiazolyl)ethylideneamino] ester 0
                        4-methoxybenzoic acid [2-(4-bromophenyl)-4-oxo-3-quinazolinyl] ester 0
                        4-methoxybenzoic acid [2-oxo-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)amino]ethyl] ester 0
                        4-methoxysalicylic acid 0
                        5-(1,3-benzodioxol-5-ylsulfamoyl)-2-methoxybenzoic acid 0
                        5-Chlorodivaricatinic acid 0
                        5-Chloropyridin-3-yl 3-methoxybenzoate 0
                        5-Methoxy-3-hydroxyanthranilate 0
                        6-Methoxysalicylic acid 0
                        Bis(4-methoxybenzoyl)-3a,29-dihydroxy-8-multifloren-7-one 0
                        Convolamine 0
                        Convoline 0
                        Convolvine 0
                        Damascenine 0
                        Differanisole A 0
                        Divaricatinic acid 0
                        Ethyl p-anisate 0
                        Ethyl vanillate 0
                        Everninic acid 0
                        Falaconitine 0
                        Hesperaline 0
                        Isoevernic acid 0
                        Methyl 2-methoxybenzoate 0
                        Methylveratrate 0
                        N-Pyruvoyl-5-methoxy-3-hydroxyanthranilate 0
                        O-methylsalicylic acid + 1
                        Phyllalbine 0
                        Rhizonic acid 0
                        SureCN668028 0
                        Verimol A 0
                        Verimol B 0
                        dicamba 5
                        eluxadoline 1
                        lignin cw compound-192 0
                        macrophomic acid 0
                        methoxysalicylic acid + 0
                        o-Anisic acid, tridec-2-ynyl ester 0
                        tricamba 0
                        vanillic acid + 15
Path 2
Term Annotations click to browse term
  CHEBI ontology 20072
    subatomic particle 20071
      composite particle 20071
        hadron 20071
          baryon 20071
            nucleon 20071
              atomic nucleus 20071
                atom 20071
                  main group element atom 19974
                    p-block element atom 19974
                      carbon group element atom 19903
                        carbon atom 19896
                          organic molecular entity 19896
                            organic group 18994
                              organic divalent group 18980
                                organodiyl group 18980
                                  carbonyl group 18933
                                    carbonyl compound 18933
                                      carboxylic acid 18629
                                        aromatic carboxylic acid 11814
                                          benzoic acids 11789
                                            methoxybenzoic acid 23
                                              2,4,5-Trimethoxybenzoic acid 0
                                              2,6-dimethoxybenzoic acid [[amino(pyridin-4-yl)methylidene]amino] ester 0
                                              2-Amino-5-methoxybenzoic acid 0
                                              2-HYDROXY-3,4-DIMETHOXYBENZOIC ACID 0
                                              2-Methoxy-4-pentadecylbenzoic acid 0
                                              2-[(carboxymethyl)(methyl)amino]-5-methoxybenzoic acid 0
                                              2-[[anilino(oxo)methyl]amino]-4,5-dimethoxybenzoic acid 0
                                              2-hydroxy-3-methoxybenzoic acid [2-[2-chloro-5-[ethyl(phenyl)sulfamoyl]anilino]-2-oxoethyl] ester 0
                                              2-hydroxy-4-methoxy-6-methylbenzoic acid ethyl ester 0
                                              2-hydroxy-4-methoxy-6-methylbenzoic acid methyl ester 0
                                              2-hydroxy-4-methoxybenzoic acid (2-methyl-4-thiazolyl)methyl ester 0
                                              2-methoxy-4-(methylthio)benzoic acid [2-(cyclopropylamino)-2-oxoethyl] ester 0
                                              2-methoxybenzoic acid 4-[[5-(1-naphthalenyl)-1,3,4-oxadiazol-2-yl]thio]but-2-ynyl ester 0
                                              3,4-Dimethoxy-1,2-benzenedicarboxylic acid 0
                                              3,4-dimethoxybenzoic acid 4-[ethyl-[1-(4-methoxyphenyl)propan-2-yl]amino]butyl ester 2
                                              3,4-dimethoxybenzoic acid [(1R,5R)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl] ester 0
                                              3,5-dimethoxybenzoic acid + 0
                                              3-chloro-2,6-dimethoxybenzoic acid 0
                                              3-decaprenyl-4-hydroxy-5-methoxybenzoic acid 0
                                              3-hexaprenyl-4-hydroxy-5-methoxybenzoic acid 0
                                              3-hydroxy-4-methoxybenzoic acid + 0
                                              3-methoxy-4-hydroxy-5-all-trans-polyprenylbenzoic acid + 0
                                              3-methoxybenzoic acid 0
                                              3-methoxybenzoic acid [[1-amino-2-(4-chlorophenyl)ethylidene]amino] ester 0
                                              3-methoxybenzoic acid [[amino-(4-nitrophenyl)methylidene]amino] ester 0
                                              3-nonaprenyl-4-hydroxy-5-methoxybenzoic acid 0
                                              4,5-Dimethoxy-1,2-benzenedicarboxylic acid 0
                                              4,5-dimethoxy-2-[[(2-methoxyanilino)-oxomethyl]amino]benzoic acid methyl ester 0
                                              4-Hydroxy-7-methoxy-1,3-benzodioxole-5-carboxylic acid 0
                                              4-O-methylolivetolcarboxylic acid 0
                                              4-[2-(5-Carboxy-2-hydroxy-3-methoxyphenyl)-2-oxoethylidene]-2-hydroxy-2-pentenedioate 0
                                              4-[2-[(2,6-dimethoxyphenyl)-oxomethoxy]-1-oxoethyl]-2,5-dimethyl-1H-pyrrole-3-carboxylic acid ethyl ester 0
                                              4-acetyloxy-3-methoxybenzoic acid (4,7,7-trimethyl-3-bicyclo[2.2.1]heptanyl) ester 0
                                              4-amino-5-chloro-2-methoxybenzoic acid 2-(diethylamino)ethyl ester 0
                                              4-amino-5-chloro-2-methoxybenzoic acid 3-(1-piperidinyl)propyl ester 0
                                              4-hydroxy-3-methoxybenzoic acid [(1S,5R)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl] ester 0
                                              4-methoxy-3-(sulfooxy)benzoic acid 0
                                              4-methoxy-3-[2-phenylethyl-(phenylmethyl)sulfamoyl]benzoic acid 0
                                              4-methoxybenzoic acid + 0
                                              4-methoxybenzoic acid 2-(4-hydroxyphenyl)ethyl ester 0
                                              4-methoxybenzoic acid 4-[[5-(1-naphthalenyl)-1,3,4-oxadiazol-2-yl]thio]but-2-ynyl ester 0
                                              4-methoxybenzoic acid [1-(2-pyrazinyl)ethylideneamino] ester 0
                                              4-methoxybenzoic acid [1-(2-thiazolyl)ethylideneamino] ester 0
                                              4-methoxybenzoic acid [2-(4-bromophenyl)-4-oxo-3-quinazolinyl] ester 0
                                              4-methoxybenzoic acid [2-oxo-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)amino]ethyl] ester 0
                                              4-methoxysalicylic acid 0
                                              5-(1,3-benzodioxol-5-ylsulfamoyl)-2-methoxybenzoic acid 0
                                              5-Chlorodivaricatinic acid 0
                                              5-Chloropyridin-3-yl 3-methoxybenzoate 0
                                              5-Methoxy-3-hydroxyanthranilate 0
                                              6-Methoxysalicylic acid 0
                                              Bis(4-methoxybenzoyl)-3a,29-dihydroxy-8-multifloren-7-one 0
                                              Convolamine 0
                                              Convoline 0
                                              Convolvine 0
                                              Damascenine 0
                                              Differanisole A 0
                                              Divaricatinic acid 0
                                              Ethyl p-anisate 0
                                              Ethyl vanillate 0
                                              Everninic acid 0
                                              Falaconitine 0
                                              Hesperaline 0
                                              Isoevernic acid 0
                                              Methyl 2-methoxybenzoate 0
                                              Methylveratrate 0
                                              N-Pyruvoyl-5-methoxy-3-hydroxyanthranilate 0
                                              O-methylsalicylic acid + 1
                                              Phyllalbine 0
                                              Rhizonic acid 0
                                              SureCN668028 0
                                              Verimol A 0
                                              Verimol B 0
                                              dicamba 5
                                              eluxadoline 1
                                              lignin cw compound-192 0
                                              macrophomic acid 0
                                              methoxysalicylic acid + 0
                                              o-Anisic acid, tridec-2-ynyl ester 0
                                              tricamba 0
                                              vanillic acid + 15
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