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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:methionine derivative
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Accession:CHEBI:25230 term browser browse the term
Definition:An amino acid derivative resulting from reaction of methionine at the amino group or the carboxy group, or from the replacement of any hydrogen of methionine by a heteroatom. The definition normally excludes peptides containing methionine residues.
Synonyms:related_synonym: methionine derivatives


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methionine sulfoximine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl2 C-C motif chemokine ligand 2 decreases expression ISO Methionine Sulfoximine results in decreased expression of CCL2 protein CTD PMID:20116850 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccl3 C-C motif chemokine ligand 3 decreases expression ISO Methionine Sulfoximine results in decreased expression of CCL3 protein CTD PMID:20116850 NCBI chr10:70,869,516...70,871,066
Ensembl chr10:70,869,513...70,871,066
JBrowse link
G Ccl4 C-C motif chemokine ligand 4 decreases expression ISO Methionine Sulfoximine results in decreased expression of CCL4 protein CTD PMID:20116850 NCBI chr10:70,870,926...70,886,357
Ensembl chr10:70,884,531...70,886,355
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 decreases expression ISO Methionine Sulfoximine results in decreased expression of CCL5 protein CTD PMID:20116850 NCBI chr10:70,739,764...70,744,303
Ensembl chr10:70,739,800...70,744,315
JBrowse link
G Gfap glial fibrillary acidic protein increases expression EXP Methionine Sulfoximine results in increased expression of GFAP protein CTD PMID:2565645 NCBI chr10:90,990,762...90,999,435
Ensembl chr10:90,990,762...90,999,506
JBrowse link
G Glul glutamate-ammonia ligase decreases activity
multiple interactions
EXP Methionine Sulfoximine results in decreased activity of GLUL protein
[Methionine Sulfoximine results in decreased activity of GLUL protein] which results in increased abundance of Ammonia
CTD PMID:19619585 NCBI chr13:71,331,052...71,340,207
Ensembl chr13:71,331,052...71,340,229
JBrowse link
G Il6r interleukin 6 receptor decreases expression ISO Methionine Sulfoximine results in decreased expression of IL6R protein modified form CTD PMID:20116850 NCBI chr 2:189,196,180...189,255,987
Ensembl chr 2:189,205,701...189,254,628
JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression ISO Methionine Sulfoximine results in decreased expression of VEGFA protein CTD PMID:20116850 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    chemical entity 19787
      atom 19784
        nonmetal atom 19659
          sulfur atom 16256
            sulfur molecular entity 16256
              organosulfur compound 15190
                methionine derivative 8
                  (2S)-2-[[[4-[[(2R)-2-amino-3-mercaptopropyl]amino]-2-phenylphenyl]-oxomethyl]amino]-4-(methylthio)butanoic acid 0
                  2-(1,3-benzothiazol-2-ylamino)-4-(methylthio)butanoic acid 0
                  2-[(6-bromo-4-quinazolinyl)amino]-4-(methylthio)butanoic acid 0
                  2-[[(4-ethylphenyl)-oxomethyl]amino]-4-(methylthio)butanoic acid methyl ester 0
                  2-amino-4-(methylsulfanyl)-N-(2-naphthyl)butanamide + 0
                  D-methionine derivative + 0
                  L-methionine derivative + 0
                  L-methionine methylsulfonium iodide 0
                  N-acetylmethionine + 0
                  methionine S-oxide + 0
                  methionine sulfone + 0
                  methionine sulfoximine + 8
                  methioninehydroxamic acid 0
                  peptidyl-methionine 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    p-block element atom 19672
                      carbon group element atom 19574
                        carbon atom 19563
                          organic molecular entity 19563
                            organic group 18495
                              organic divalent group 18488
                                organodiyl group 18488
                                  carbonyl group 18391
                                    carbonyl compound 18391
                                      carboxylic acid 18061
                                        monocarboxylic acid 17407
                                          fatty acid 15845
                                            short-chain fatty acid 15500
                                              fatty acid 4:0 7011
                                                butyric acid 5292
                                                  methionine 3432
                                                    methionine derivative 8
                                                      (2S)-2-[[[4-[[(2R)-2-amino-3-mercaptopropyl]amino]-2-phenylphenyl]-oxomethyl]amino]-4-(methylthio)butanoic acid 0
                                                      2-(1,3-benzothiazol-2-ylamino)-4-(methylthio)butanoic acid 0
                                                      2-[(6-bromo-4-quinazolinyl)amino]-4-(methylthio)butanoic acid 0
                                                      2-[[(4-ethylphenyl)-oxomethyl]amino]-4-(methylthio)butanoic acid methyl ester 0
                                                      2-amino-4-(methylsulfanyl)-N-(2-naphthyl)butanamide + 0
                                                      D-methionine derivative + 0
                                                      L-methionine derivative + 0
                                                      L-methionine methylsulfonium iodide 0
                                                      N-acetylmethionine + 0
                                                      methionine S-oxide + 0
                                                      methionine sulfone + 0
                                                      methionine sulfoximine + 8
                                                      methioninehydroxamic acid 0
                                                      peptidyl-methionine 0
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