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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:methionine derivative
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Accession:CHEBI:25230 term browser browse the term
Definition:An amino acid derivative resulting from reaction of methionine at the amino group or the carboxy group, or from the replacement of any hydrogen of methionine by a heteroatom. The definition normally excludes peptides containing methionine residues.
Synonyms:related_synonym: methionine derivatives


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methionine sulfoximine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl2 C-C motif chemokine ligand 2 decreases expression ISO Methionine Sulfoximine results in decreased expression of CCL2 protein CTD PMID:20116850 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Ccl3 C-C motif chemokine ligand 3 decreases expression ISO Methionine Sulfoximine results in decreased expression of CCL3 protein CTD PMID:20116850 NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938
JBrowse link
G Ccl4 C-C motif chemokine ligand 4 decreases expression ISO Methionine Sulfoximine results in decreased expression of CCL4 protein CTD PMID:20116850 NCBI chr10:68,466,469...68,467,941
Ensembl chr10:68,452,052...68,468,231
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 decreases expression ISO Methionine Sulfoximine results in decreased expression of CCL5 protein CTD PMID:20116850 NCBI chr10:68,322,826...68,327,365
Ensembl chr10:68,322,829...68,327,377
JBrowse link
G Gfap glial fibrillary acidic protein increases expression EXP Methionine Sulfoximine results in increased expression of GFAP protein CTD PMID:2565645 NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589
JBrowse link
G Glul glutamate-ammonia ligase decreases activity
multiple interactions
EXP Methionine Sulfoximine results in decreased activity of GLUL protein
[Methionine Sulfoximine results in decreased activity of GLUL protein] which results in increased abundance of Ammonia
CTD PMID:19619585 NCBI chr13:65,969,064...66,035,121
Ensembl chr13:66,025,630...66,035,108
JBrowse link
G Il6r interleukin 6 receptor decreases expression ISO Methionine Sulfoximine results in decreased expression of IL6R protein modified form CTD PMID:20116850 NCBI chr 2:175,289,157...175,347,719
Ensembl chr 2:175,298,686...175,347,536
JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression ISO Methionine Sulfoximine results in decreased expression of VEGFA protein CTD PMID:20116850 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19812
    chemical entity 19812
      atom 19811
        nonmetal atom 19698
          sulfur atom 16395
            sulfur molecular entity 16395
              organosulfur compound 15272
                methionine derivative 8
                  (2S)-2-[[[4-[[(2R)-2-amino-3-mercaptopropyl]amino]-2-phenylphenyl]-oxomethyl]amino]-4-(methylthio)butanoic acid 0
                  2-(1,3-benzothiazol-2-ylamino)-4-(methylthio)butanoic acid 0
                  2-[(6-bromo-4-quinazolinyl)amino]-4-(methylthio)butanoic acid 0
                  2-[[(4-ethylphenyl)-oxomethyl]amino]-4-(methylthio)butanoic acid methyl ester 0
                  2-amino-4-(methylsulfanyl)-N-(2-naphthyl)butanamide + 0
                  D-methionine derivative + 0
                  L-methionine derivative + 0
                  L-methionine methylsulfonium iodide 0
                  N-(1-Deoxy-1-fructosyl)methionine 0
                  N-Oleoyl methionine 0
                  N-[(2S)-2-Hydroxypropanoyl]methionine 0
                  N-acetylmethionine + 0
                  methionine S-oxide + 0
                  methionine sulfone + 0
                  methionine sulfoximine + 8
                  methioninehydroxamic acid 0
                  peptidyl-methionine 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19812
    subatomic particle 19811
      composite particle 19811
        hadron 19811
          baryon 19811
            nucleon 19811
              atomic nucleus 19811
                atom 19811
                  main group element atom 19708
                    p-block element atom 19708
                      carbon group element atom 19630
                        carbon atom 19620
                          organic molecular entity 19620
                            organic group 18728
                              organic divalent group 18719
                                organodiyl group 18719
                                  carbonyl group 18667
                                    carbonyl compound 18667
                                      carboxylic acid 18364
                                        monocarboxylic acid 17632
                                          fatty acid 16012
                                            short-chain fatty acid 15700
                                              fatty acid 4:0 7901
                                                butyric acid 6271
                                                  methionine 3458
                                                    methionine derivative 8
                                                      (2S)-2-[[[4-[[(2R)-2-amino-3-mercaptopropyl]amino]-2-phenylphenyl]-oxomethyl]amino]-4-(methylthio)butanoic acid 0
                                                      2-(1,3-benzothiazol-2-ylamino)-4-(methylthio)butanoic acid 0
                                                      2-[(6-bromo-4-quinazolinyl)amino]-4-(methylthio)butanoic acid 0
                                                      2-[[(4-ethylphenyl)-oxomethyl]amino]-4-(methylthio)butanoic acid methyl ester 0
                                                      2-amino-4-(methylsulfanyl)-N-(2-naphthyl)butanamide + 0
                                                      D-methionine derivative + 0
                                                      L-methionine derivative + 0
                                                      L-methionine methylsulfonium iodide 0
                                                      N-(1-Deoxy-1-fructosyl)methionine 0
                                                      N-Oleoyl methionine 0
                                                      N-[(2S)-2-Hydroxypropanoyl]methionine 0
                                                      N-acetylmethionine + 0
                                                      methionine S-oxide + 0
                                                      methionine sulfone + 0
                                                      methionine sulfoximine + 8
                                                      methioninehydroxamic acid 0
                                                      peptidyl-methionine 0
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