p-menthane monoterpenoid - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	p-menthane monoterpenoid	go back to main search page
Accession:	CHEBI:25186	browse the term
Synonyms:	related_synonym:	p-menthane monoterpenoids

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Rat (489) Mouse (489) Human (502) Chinchilla (0) Bonobo (0) Dog (2) Squirrel (0) Pig (1) Green Monkey (0) Naked Mole-rat (0) All
Genes (489)

(S)-(-)-perillyl alcohol

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

BCL2-antagonist/killer 1

increases expression

perillyl alcohol results in increased expression of BAK1 protein

NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264

G

BCL2 associated X, apoptosis regulator

multiple interactions

perillyl alcohol inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased expression of BAX protein]

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

BCL2, apoptosis regulator

multiple interactions

perillyl alcohol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of BCL2 protein]

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

catalase

multiple interactions

perillyl alcohol inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased activity of CAT protein]
perillyl alcohol inhibits the reaction [Ethanol results in decreased activity of CAT protein]

PMID:19161993 PMID:20923693

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

cyclin A2

decreases expression

perillyl alcohol results in decreased expression of CCNA2 protein

NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577

G

cyclin B1

decreases expression

perillyl alcohol results in decreased expression of CCNB1 protein

NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172

G

cyclin dependent kinase 2

decreases expression
multiple interactions

perillyl alcohol results in decreased expression of CDK2 protein
perillyl alcohol promotes the reaction [CDKN1A protein binds to and results in decreased activity of CDK2 protein]; perillyl alcohol promotes the reaction [CDKN1B protein binds to and results in decreased activity of CDK2 protein]

NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403

G

cyclin-dependent kinase inhibitor 1A

increases response to substance
multiple interactions
increases expression

CDKN1A protein results in increased susceptibility to perillyl alcohol
perillyl alcohol promotes the reaction [CDKN1A protein binds to and results in decreased activity of CDK2 protein]
perillyl alcohol results in increased expression of CDKN1A protein

NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585

G

cyclin-dependent kinase inhibitor 1B

increases expression
increases response to substance
multiple interactions

perillyl alcohol results in increased expression of CDKN1B protein
CDKN1B protein results in increased susceptibility to perillyl alcohol
perillyl alcohol promotes the reaction [CDKN1B protein binds to and results in decreased activity of CDK2 protein]

NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982

G

F-box protein 32

increases expression

perillyl alcohol results in increased expression of FBXO32 mRNA; perillyl alcohol results in increased expression of FBXO32 protein

NCBI chr 7:89,731,428...89,764,997
Ensembl chr 7:89,730,232...89,765,436

G

farnesyltransferase, CAAX box, subunit alpha

multiple interactions

[Vitamin A co-treated with perillyl alcohol] results in decreased expression of FNTA protein

NCBI chr16:66,065,131...66,083,460
Ensembl chr16:66,065,132...66,083,460

G

farnesyltransferase, CAAX box, subunit beta

multiple interactions
increases expression
decreases expression

[perillyl alcohol co-treated with Vitamin A] results in decreased expression of FNTB mRNA
perillyl alcohol results in increased expression of FNTB protein
perillyl alcohol results in decreased expression of FNTB mRNA

NCBI chr 6:95,536,540...95,619,587
Ensembl chr 6:95,470,683...95,619,586

G

glutathione-disulfide reductase

multiple interactions

perillyl alcohol inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased expression of GSR protein]
perillyl alcohol inhibits the reaction [Ethanol results in decreased activity of GSR protein]

PMID:19161993 PMID:20923693

NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661

G

hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)

multiple interactions

perillyl alcohol inhibits the reaction [Ethanol results in decreased activity of H6PD protein]

NCBI chr 5:160,434,499...160,470,203
Ensembl chr 5:160,438,697...160,470,171

G

involucrin

decreases expression

perillyl alcohol results in decreased expression of IVL protein

NCBI chr 2:178,146,694...178,160,807
Ensembl chr 2:178,147,061...178,149,100

G

mitogen activated protein kinase 1

multiple interactions

perillyl alcohol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK1 protein]

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

multiple interactions

perillyl alcohol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK3 protein]

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

ornithine decarboxylase 1

multiple interactions

perillyl alcohol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of ODC1 protein]

NCBI chr 6:40,329,831...40,336,444
Ensembl chr 6:40,329,964...40,336,440

G

Raf-1 proto-oncogene, serine/threonine kinase

multiple interactions

perillyl alcohol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of RAF1 protein]

NCBI chr 4:148,679,534...148,740,265
Ensembl chr 4:148,679,530...148,740,317

G

RAP1A, member of RAS oncogene family

multiple interactions
increases expression

Mevalonic Acid affects the reaction [perillyl alcohol results in increased expression of RAP1A protein]

NCBI chr 2:193,208,631...193,286,513
Ensembl chr 2:193,208,635...193,286,501

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

perillyl alcohol inhibits the reaction [Ethanol results in increased activity of RELA protein]

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

ras homolog family member A

multiple interactions
increases expression

Mevalonic Acid affects the reaction [perillyl alcohol results in increased expression of RHOA protein]
[perillyl alcohol co-treated with Vitamin A] results in increased expression of RHOA mRNA

PMID:12671036 PMID:15959631

NCBI chr 8:108,991,926...109,025,746
Ensembl chr 8:108,991,954...109,025,746

G

ras homolog family member B

multiple interactions
increases expression

Mevalonic Acid affects the reaction [perillyl alcohol results in increased expression of RHOB protein]
perillyl alcohol results in increased expression of RHOB mRNA; perillyl alcohol results in increased expression of RHOB protein
[perillyl alcohol co-treated with Vitamin A] affects the expression of RHOB mRNA; [perillyl alcohol co-treated with Vitamin A] affects the expression of RHOB protein

PMID:12671036 PMID:15959631

NCBI chr 6:31,363,752...31,365,926
Ensembl chr 6:31,363,548...31,366,108

G

tumor necrosis factor

multiple interactions

perillyl alcohol inhibits the reaction [Ethanol results in increased expression of TNF protein]

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

1,8-cineole

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

acetyl-CoA carboxylase alpha

multiple interactions

[beta-thujone co-treated with linalyl acetate co-treated with sabinene co-treated with linalool co-treated with Camphor co-treated with myrcene co-treated with Eucalyptol co-treated with caryophyllene co-treated with spathulenol] results in decreased expression of ACACA mRNA

NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457

G

acetyl-CoA carboxylase beta

multiple interactions

[beta-thujone co-treated with linalyl acetate co-treated with sabinene co-treated with linalool co-treated with Camphor co-treated with myrcene co-treated with Eucalyptol co-treated with caryophyllene co-treated with spathulenol] results in increased expression of ACACB mRNA

NCBI chr12:42,365,800...42,477,651
Ensembl chr12:42,366,548...42,457,655

G

ATP citrate lyase

multiple interactions

[beta-thujone co-treated with linalyl acetate co-treated with sabinene co-treated with linalool co-treated with Camphor co-treated with myrcene co-treated with Eucalyptol co-treated with caryophyllene co-treated with spathulenol] results in decreased expression of ACLY mRNA

NCBI chr10:85,412,045...85,464,253
Ensembl chr10:85,412,049...85,463,320

G

actin alpha 2, smooth muscle

multiple interactions

[beta-thujone co-treated with linalyl acetate co-treated with sabinene co-treated with linalool co-treated with Camphor co-treated with myrcene co-treated with Eucalyptol co-treated with caryophyllene co-treated with spathulenol] results in decreased expression of ACTA2 mRNA

NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554

G

actin related protein 2

multiple interactions

Eucalyptol inhibits the reaction [Glucose results in decreased expression of ACTR2 protein]

NCBI chr14:94,296,443...94,333,735
Ensembl chr14:94,296,443...94,340,524

G

aryl hydrocarbon receptor

multiple interactions

[beta-thujone co-treated with linalyl acetate co-treated with sabinene co-treated with linalool co-treated with Camphor co-treated with myrcene co-treated with Eucalyptol co-treated with caryophyllene co-treated with spathulenol] results in increased expression of AHR mRNA

NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568

G

AKT serine/threonine kinase 1

multiple interactions

[beta-thujone co-treated with linalyl acetate co-treated with sabinene co-treated with linalool co-treated with Camphor co-treated with myrcene co-treated with Eucalyptol co-treated with caryophyllene co-treated with spathulenol] results in increased expression of AKT1 mRNA

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

ankyrin repeat domain 17

decreases expression

Eucalyptol results in decreased expression of ANKRD17 mRNA

NCBI chr14:17,723,239...17,861,841
Ensembl chr14:17,721,932...17,862,617

G

APC regulator of WNT signaling pathway

increases expression

Eucalyptol results in increased expression of APC mRNA

NCBI chr18:25,828,558...25,925,511
Ensembl chr18:25,864,222...25,922,696

G

achaete-scute family bHLH transcription factor 1

decreases expression

Eucalyptol results in decreased expression of ASCL1 mRNA

NCBI chr 7:21,903,136...21,906,003
Ensembl chr 7:21,903,126...21,905,993

G

BCL2-associated agonist of cell death

increases expression

Eucalyptol results in increased expression of BAD mRNA

NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823

G

catalase

multiple interactions

[beta-thujone co-treated with linalyl acetate co-treated with sabinene co-treated with linalool co-treated with Camphor co-treated with myrcene co-treated with Eucalyptol co-treated with caryophyllene co-treated with spathulenol] results in decreased expression of CAT mRNA

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

cellular communication network factor 2

multiple interactions

[beta-thujone co-treated with linalyl acetate co-treated with sabinene co-treated with linalool co-treated with Camphor co-treated with myrcene co-treated with Eucalyptol co-treated with caryophyllene co-treated with spathulenol] results in increased expression of CTGF mRNA

NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734

G

cell division cycle 42

multiple interactions

Eucalyptol inhibits the reaction [Glucose results in increased expression of CDC42 protein]; Eucalyptol inhibits the reaction [LEP gene mutant form results in increased expression of CDC42 protein]

NCBI chr 5:149,555,069...149,593,239
Ensembl chr 5:149,553,724...149,593,111

G

Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2

decreases expression

Eucalyptol results in decreased expression of CITED2 mRNA

NCBI chr 1:12,312,426...12,314,869
Ensembl chr 1:12,312,160...12,314,897

G

collagen type I alpha 1 chain

multiple interactions

[beta-thujone co-treated with linalyl acetate co-treated with sabinene co-treated with linalool co-treated with Camphor co-treated with myrcene co-treated with Eucalyptol co-treated with caryophyllene co-treated with spathulenol] results in decreased expression of COL1A1 mRNA

NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624

G

carnitine palmitoyltransferase 1A

multiple interactions

[beta-thujone co-treated with linalyl acetate co-treated with sabinene co-treated with linalool co-treated with Camphor co-treated with myrcene co-treated with Eucalyptol co-treated with caryophyllene co-treated with spathulenol] results in increased expression of CPT1A mRNA

NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055

G

carnitine palmitoyltransferase 2

multiple interactions

[beta-thujone co-treated with linalyl acetate co-treated with sabinene co-treated with linalool co-treated with Camphor co-treated with myrcene co-treated with Eucalyptol co-treated with caryophyllene co-treated with spathulenol] results in increased expression of CPT2 mRNA

NCBI chr 5:122,664,677...122,682,126
Ensembl chr 5:122,664,677...122,682,095

G

cathepsin D

multiple interactions
increases expression

Fulvestrant inhibits the reaction [Eucalyptol results in increased expression of CTSD mRNA]

NCBI chr 1:197,527,467...197,539,343
Ensembl chr 1:197,527,467...197,539,488

G

cortactin

multiple interactions

Eucalyptol inhibits the reaction [Glucose results in decreased expression of CTTN protein]; Eucalyptol inhibits the reaction [LEP gene mutant form results in decreased expression of CTTN protein]

NCBI chr 1:199,599,710...199,635,254
Ensembl chr 1:199,599,710...199,635,164

G

cytochrome P450, family 1, subfamily a, polypeptide 1

multiple interactions

[beta-thujone co-treated with linalyl acetate co-treated with sabinene co-treated with linalool co-treated with Camphor co-treated with myrcene co-treated with Eucalyptol co-treated with caryophyllene co-treated with spathulenol] results in increased expression of CYP1A1 mRNA

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

G

cytochrome P450, family 2, subfamily b, polypeptide 3

multiple interactions

Eucalyptol inhibits the reaction [CYP2B6 protein results in increased hydrolysis of Bupropion]

NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143

G

cytochrome P450, family 3, subfamily a, polypeptide 2

increases hydroxylation
multiple interactions

CYP3A4 protein results in increased hydroxylation of Eucalyptol
Eucalyptol inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Midazolam]

PMID:15715982 PMID:18385293

NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008

G

cytochrome P450, family 3, subfamily a, polypeptide 9

increases hydroxylation

CYP3A5 protein results in increased hydroxylation of Eucalyptol

NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422

G

diacylglycerol O-acyltransferase 1

multiple interactions

[beta-thujone co-treated with linalyl acetate co-treated with sabinene co-treated with linalool co-treated with Camphor co-treated with myrcene co-treated with Eucalyptol co-treated with caryophyllene co-treated with spathulenol] results in increased expression of DGAT1 mRNA

NCBI chr 7:108,223,860...108,235,413
Ensembl chr 7:108,218,524...108,234,299

G

ezrin

multiple interactions

Eucalyptol inhibits the reaction [Glucose results in decreased expression of EZR protein]; Eucalyptol inhibits the reaction [LEP gene mutant form results in decreased expression of EZR protein]

NCBI chr 1:46,967,961...47,011,505
Ensembl chr 1:46,967,658...47,011,505

G

fatty acid synthase

multiple interactions

[beta-thujone co-treated with linalyl acetate co-treated with sabinene co-treated with linalool co-treated with Camphor co-treated with myrcene co-treated with Eucalyptol co-treated with caryophyllene co-treated with spathulenol] results in increased expression of FASN mRNA

NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261

G

forkhead box O1

multiple interactions

[beta-thujone co-treated with linalyl acetate co-treated with sabinene co-treated with linalool co-treated with Camphor co-treated with myrcene co-treated with Eucalyptol co-treated with caryophyllene co-treated with spathulenol] results in increased expression of FOXO1 mRNA

NCBI chr 2:136,312,168...136,390,603
Ensembl chr 2:136,312,168...136,387,790

G

glutathione peroxidase 1

multiple interactions

[beta-thujone co-treated with linalyl acetate co-treated with sabinene co-treated with linalool co-treated with Camphor co-treated with myrcene co-treated with Eucalyptol co-treated with caryophyllene co-treated with spathulenol] results in increased expression of GPX1 mRNA

NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024

G

growth regulating estrogen receptor binding 1

multiple interactions
increases expression

Fulvestrant inhibits the reaction [Eucalyptol results in increased expression of GREB1 mRNA]

NCBI chr 6:39,440,522...39,562,364
Ensembl chr 6:39,440,504...39,581,633

G

glycogen synthase kinase 3 beta

multiple interactions

Eucalyptol inhibits the reaction [Glucose results in increased expression of GSK3B protein]; RHOA protein inhibits the reaction [Eucalyptol inhibits the reaction [Glucose results in increased expression of GSK3B protein]]

NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646

G

glutathione-disulfide reductase

multiple interactions

[beta-thujone co-treated with linalyl acetate co-treated with sabinene co-treated with linalool co-treated with Camphor co-treated with myrcene co-treated with Eucalyptol co-treated with caryophyllene co-treated with spathulenol] results in increased expression of GSR mRNA

NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661

G

3-hydroxy-3-methylglutaryl-CoA reductase

decreases expression

Eucalyptol results in decreased expression of HMGCR protein

NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703

G

intercellular adhesion molecule 1

multiple interactions

Eucalyptol inhibits the reaction [Tobacco Smoke Pollution results in increased expression of ICAM1 mRNA]; Eucalyptol inhibits the reaction [Tobacco Smoke Pollution results in increased expression of ICAM1 protein]

NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438

G

interleukin 1 beta

multiple interactions

[Ibuprofen co-treated with Eucalyptol] inhibits the reaction [ammonium acetate results in increased expression of IL1B mRNA]; Eucalyptol inhibits the reaction [ammonium acetate results in increased expression of IL1B mRNA]

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 6

multiple interactions

[Ibuprofen co-treated with Eucalyptol] inhibits the reaction [ammonium acetate results in increased expression of IL6 mRNA]; Eucalyptol inhibits the reaction [ammonium acetate results in increased expression of IL6 mRNA]; Eucalyptol inhibits the reaction [Tobacco Smoke Pollution results in increased expression of IL6 protein]

PMID:29789401 PMID:36346500

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

lymphoid enhancer binding factor 1

decreases expression

Eucalyptol results in decreased expression of LEF1 mRNA

NCBI chr 2:219,666,549...219,779,815
Ensembl chr 2:219,666,592...219,779,794

G

leptin

multiple interactions

Eucalyptol inhibits the reaction [LEP gene mutant form results in decreased expression of CTTN protein]; Eucalyptol inhibits the reaction [LEP gene mutant form results in decreased expression of EZR protein]; Eucalyptol inhibits the reaction [LEP gene mutant form results in decreased expression of PTK2 protein]; Eucalyptol inhibits the reaction [LEP gene mutant form results in decreased expression of PXN protein]; Eucalyptol inhibits the reaction [LEP gene mutant form results in decreased expression of SRC protein]; Eucalyptol inhibits the reaction [LEP gene mutant form results in decreased expression of SYNPO protein]; Eucalyptol inhibits the reaction [LEP gene mutant form results in decreased expression of TLN1 protein]; Eucalyptol inhibits the reaction [LEP gene mutant form results in decreased expression of VCL protein]; Eucalyptol inhibits the reaction [LEP gene mutant form results in increased abundance of Blood Glucose]; Eucalyptol inhibits the reaction [LEP gene mutant form results in increased expression of CDC42 protein]; Eucalyptol inhibits the reaction [LEP gene mutant form results in increased expression of PXN protein modified form]; Eucalyptol inhibits the reaction [LEP gene mutant form results in increased expression of RAC1 protein]; Eucalyptol inhibits the reaction [LEP gene mutant form results in increased expression of RHOA protein]; Eucalyptol inhibits the reaction [LEP gene mutant form results in increased expression of ROCK1 protein]; Eucalyptol inhibits the reaction [LEP gene mutant form results in increased expression of VCL protein modified form]

NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262

G

mitogen-activated protein kinase 8

multiple interactions

Eucalyptol inhibits the reaction [Lipopolysaccharides results in decreased expression of and results in decreased phosphorylation of MAPK8 protein]

NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981

G

mitogen-activated protein kinase 9

multiple interactions

Eucalyptol inhibits the reaction [Lipopolysaccharides results in decreased expression of and results in decreased phosphorylation of MAPK9 protein]

NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178

G

malonyl-CoA decarboxylase

multiple interactions

[beta-thujone co-treated with linalyl acetate co-treated with sabinene co-treated with linalool co-treated with Camphor co-treated with myrcene co-treated with Eucalyptol co-treated with caryophyllene co-treated with spathulenol] results in increased expression of MLYCD mRNA

NCBI chr19:47,447,931...47,463,794
Ensembl chr19:47,447,970...47,463,793

G

mucin 19, oligomeric

decreases expression

Eucalyptol results in decreased expression of MUC19 mRNA

NCBI chr 7:123,017,896...123,139,053
Ensembl chr 7:123,017,896...123,139,053

G

mucin 2, oligomeric mucus/gel-forming

multiple interactions

Eucalyptol inhibits the reaction [Lipopolysaccharides results in increased expression of MUC2 mRNA]

NCBI chr 1:196,799,494...196,831,740
Ensembl chr 1:196,799,517...196,831,756

G

mucin 5AC, oligomeric mucus/gel-forming

multiple interactions

Eucalyptol inhibits the reaction [Tobacco Smoke Pollution results in increased expression of MUC5AC mRNA]; Eucalyptol inhibits the reaction [Tobacco Smoke Pollution results in increased expression of MUC5AC protein]

NCBI chr 1:196,864,336...196,896,475
Ensembl chr 1:196,864,336...196,896,475

G

MYC proto-oncogene, bHLH transcription factor

decreases expression

Eucalyptol results in decreased expression of MYC mRNA

NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630

G

NFE2 like bZIP transcription factor 2

multiple interactions

[beta-thujone co-treated with linalyl acetate co-treated with sabinene co-treated with linalool co-treated with Camphor co-treated with myrcene co-treated with Eucalyptol co-treated with caryophyllene co-treated with spathulenol] results in increased expression of NFE2L2 mRNA

NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737

G

nuclear factor kappa B subunit 1

multiple interactions

[beta-thujone co-treated with linalyl acetate co-treated with sabinene co-treated with linalool co-treated with Camphor co-treated with myrcene co-treated with Eucalyptol co-treated with caryophyllene co-treated with spathulenol] results in increased expression of NFKB1 mRNA

NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404

G

NFKB inhibitor alpha

multiple interactions

Eucalyptol inhibits the reaction [Lipopolysaccharides affects the expression of NFKBIA protein]; Eucalyptol inhibits the reaction [Lipopolysaccharides inhibits the reaction [RELA protein binds to NFKBIA protein]]

NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941

G

nuclear receptor subfamily 4, group A, member 3

decreases expression

Eucalyptol results in decreased expression of NR4A3 mRNA

NCBI chr 5:62,361,588...62,401,489
Ensembl chr 5:62,361,822...62,402,733

G

platelet derived growth factor receptor beta

decreases expression

Eucalyptol results in decreased expression of PDGFRB mRNA

NCBI chr18:54,499,962...54,538,840
Ensembl chr18:54,499,964...54,538,843

G

peroxisome proliferator activated receptor alpha

multiple interactions

[beta-thujone co-treated with linalyl acetate co-treated with sabinene co-treated with linalool co-treated with Camphor co-treated with myrcene co-treated with Eucalyptol co-treated with caryophyllene co-treated with spathulenol] results in increased expression of PPARA mRNA

NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346

G

prostaglandin-endoperoxide synthase 1

multiple interactions

[beta-thujone co-treated with linalyl acetate co-treated with sabinene co-treated with linalool co-treated with Camphor co-treated with myrcene co-treated with Eucalyptol co-treated with caryophyllene co-treated with spathulenol] results in increased expression of PTGS1 mRNA

NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586

G

protein tyrosine kinase 2

multiple interactions

Eucalyptol inhibits the reaction [Glucose results in decreased expression of PTK2 protein]; Eucalyptol inhibits the reaction [LEP gene mutant form results in decreased expression of PTK2 protein]

NCBI chr 7:105,126,725...105,331,848
Ensembl chr 7:105,126,728...105,331,783

G

protein tyrosine kinase 6

decreases expression

Eucalyptol results in decreased expression of PTK6 mRNA

NCBI chr 3:168,307,073...168,315,664
Ensembl chr 3:168,307,073...168,315,664

G

paxillin

multiple interactions

Eucalyptol inhibits the reaction [Glucose results in decreased expression of PXN protein]; Eucalyptol inhibits the reaction [Glucose results in increased expression of PXN protein modified form]; Eucalyptol inhibits the reaction [LEP gene mutant form results in decreased expression of PXN protein]; Eucalyptol inhibits the reaction [LEP gene mutant form results in increased expression of PXN protein modified form]; RHOA protein promotes the reaction [Eucalyptol inhibits the reaction [Glucose results in decreased expression of PXN protein]]

NCBI chr12:41,060,791...41,107,952
Ensembl chr12:41,060,791...41,107,931

G

Rac family small GTPase 1

multiple interactions

Eucalyptol inhibits the reaction [Glucose results in increased expression of RAC1 protein]; Eucalyptol inhibits the reaction [LEP gene mutant form results in increased expression of RAC1 protein]

NCBI chr12:11,037,028...11,057,251
Ensembl chr12:11,036,698...11,057,251

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

Eucalyptol inhibits the reaction [Lipopolysaccharides inhibits the reaction [RELA protein binds to NFKBIA protein]]

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

ras homolog family member A

multiple interactions

Eucalyptol inhibits the reaction [Glucose results in increased expression of RHOA protein]; Eucalyptol inhibits the reaction [LEP gene mutant form results in increased expression of RHOA protein]; RHOA protein inhibits the reaction [Eucalyptol inhibits the reaction [Glucose results in increased expression of GSK3B protein]]; RHOA protein promotes the reaction [Eucalyptol inhibits the reaction [Glucose results in decreased expression of PXN protein]]; RHOA protein promotes the reaction [Eucalyptol inhibits the reaction [Glucose results in decreased expression of VCL protein]]

NCBI chr 8:108,991,926...109,025,746
Ensembl chr 8:108,991,954...109,025,746

G

Rho-associated coiled-coil containing protein kinase 1

multiple interactions

Eucalyptol inhibits the reaction [Glucose results in increased expression of ROCK1 protein]; Eucalyptol inhibits the reaction [LEP gene mutant form results in increased expression of ROCK1 protein]

NCBI chr18:1,114,532...1,236,345
Ensembl chr18:1,115,905...1,235,571

G

SEC14-like lipid binding 2

multiple interactions

Eucalyptol inhibits the reaction [Testosterone results in increased expression of SEC14L2 mRNA]

NCBI chr14:78,973,805...78,998,480
Ensembl chr14:78,973,808...78,993,788

G

snail family transcriptional repressor 1

multiple interactions

[beta-thujone co-treated with linalyl acetate co-treated with sabinene co-treated with linalool co-treated with Camphor co-treated with myrcene co-treated with Eucalyptol co-treated with caryophyllene co-treated with spathulenol] results in increased expression of SNAI1 mRNA

NCBI chr 3:156,248,479...156,252,969
Ensembl chr 3:156,248,485...156,252,969

G

superoxide dismutase 1

multiple interactions

[beta-thujone co-treated with linalyl acetate co-treated with sabinene co-treated with linalool co-treated with Camphor co-treated with myrcene co-treated with Eucalyptol co-treated with caryophyllene co-treated with spathulenol] results in increased expression of SOD1 mRNA

NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249

G

SRC proto-oncogene, non-receptor tyrosine kinase

multiple interactions

Eucalyptol inhibits the reaction [Glucose results in decreased expression of SRC protein]; Eucalyptol inhibits the reaction [LEP gene mutant form results in decreased expression of SRC protein]

NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476

G

synaptopodin

multiple interactions

Eucalyptol inhibits the reaction [LEP gene mutant form results in decreased expression of SYNPO protein]

NCBI chr18:54,048,299...54,106,388
Ensembl chr18:54,026,152...54,102,126

G

T-box transcription factor 3

affects expression

Eucalyptol affects the expression of TBX3 mRNA

NCBI chr12:36,879,924...36,894,849
Ensembl chr12:36,881,445...36,893,708

G

transforming growth factor, beta 1

multiple interactions

[beta-thujone co-treated with linalyl acetate co-treated with sabinene co-treated with linalool co-treated with Camphor co-treated with myrcene co-treated with Eucalyptol co-treated with caryophyllene co-treated with spathulenol] results in decreased expression of TGFB1 mRNA

NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847

G

transglutaminase 1

decreases expression

Eucalyptol results in decreased expression of TGM1 mRNA

NCBI chr15:29,191,039...29,206,000
Ensembl chr15:29,191,041...29,204,523

G

talin 1

multiple interactions

Eucalyptol inhibits the reaction [Glucose results in decreased expression of TLN1 protein]; Eucalyptol inhibits the reaction [LEP gene mutant form results in decreased expression of TLN1 protein]

NCBI chr 5:57,787,670...57,817,900
Ensembl chr 5:57,787,943...57,817,900

G

tumor necrosis factor

multiple interactions

Eucalyptol inhibits the reaction [Tobacco Smoke Pollution results in increased expression of TNF protein]
Eucalyptol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]

PMID:23872422 PMID:26207629 PMID:29789401

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

tripartite motif-containing 21

decreases expression

Eucalyptol results in decreased expression of TRIM21 mRNA

NCBI chr 1:156,964,896...156,987,504
Ensembl chr 1:156,964,913...156,987,440

G

vinculin

multiple interactions

Eucalyptol inhibits the reaction [Glucose results in decreased expression of VCL protein]; Eucalyptol inhibits the reaction [Glucose results in increased expression of VCL protein modified form]; Eucalyptol inhibits the reaction [LEP gene mutant form results in decreased expression of VCL protein]; Eucalyptol inhibits the reaction [LEP gene mutant form results in increased expression of VCL protein modified form]; RHOA protein promotes the reaction [Eucalyptol inhibits the reaction [Glucose results in decreased expression of VCL protein]]

NCBI chr15:3,265,776...3,355,586
Ensembl chr15:3,265,815...3,355,606

G

zinc finger E-box binding homeobox 1

multiple interactions

[beta-thujone co-treated with linalyl acetate co-treated with sabinene co-treated with linalool co-treated with Camphor co-treated with myrcene co-treated with Eucalyptol co-treated with caryophyllene co-treated with spathulenol] results in increased expression of ZEB1 mRNA

NCBI chr17:51,948,948...52,116,018
Ensembl chr17:51,948,948...52,115,214

G

zinc finger E-box binding homeobox 2

multiple interactions

[beta-thujone co-treated with linalyl acetate co-treated with sabinene co-treated with linalool co-treated with Camphor co-treated with myrcene co-treated with Eucalyptol co-treated with caryophyllene co-treated with spathulenol] results in increased expression of ZEB2 mRNA

NCBI chr 3:29,214,581...29,344,890
Ensembl chr 3:29,218,301...29,345,157

4-terpineol

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

cathepsin D

increases expression
multiple interactions

terpinenol-4 results in increased expression of CTSD mRNA
Fulvestrant inhibits the reaction [terpinenol-4 results in increased expression of CTSD mRNA]

NCBI chr 1:197,527,467...197,539,343
Ensembl chr 1:197,527,467...197,539,488

G

cytochrome P450, family 4, subfamily f, polypeptide 6

multiple interactions

terpinenol-4 inhibits the reaction [Testosterone results in increased expression of CYP4F8 mRNA]

NCBI chr 7:12,030,276...12,058,020
Ensembl chr 7:12,030,301...12,057,782

G

estrogen receptor 1

increases activity
multiple interactions

terpinenol-4 results in increased activity of ESR1 protein
NCOA2 protein promotes the reaction [terpinenol-4 results in increased activity of ESR1 protein]

NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002

G

growth regulating estrogen receptor binding 1

increases expression
multiple interactions

terpinenol-4 results in increased expression of GREB1 mRNA
Fulvestrant inhibits the reaction [terpinenol-4 results in increased expression of GREB1 mRNA]

NCBI chr 6:39,440,522...39,562,364
Ensembl chr 6:39,440,504...39,581,633

G

nuclear receptor coactivator 2

multiple interactions

NCOA2 protein promotes the reaction [terpinenol-4 results in increased activity of ESR1 protein]

NCBI chr 5:5,835,642...6,069,693
Ensembl chr 5:5,835,706...6,067,451

G

progesterone receptor

multiple interactions
increases expression

Fulvestrant inhibits the reaction [terpinenol-4 results in increased expression of PGR mRNA]

NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:6,072,673...6,131,344

G

SEC14-like lipid binding 2

multiple interactions

terpinenol-4 inhibits the reaction [Testosterone results in increased expression of SEC14L2 mRNA]

NCBI chr14:78,973,805...78,998,480
Ensembl chr14:78,973,808...78,993,788

G

UDP glucuronosyltransferase family 2 member B15

increases metabolic processing

UGT2B15 protein results in increased metabolism of terpinenol-4

NCBI chr14:20,768,015...20,783,599
Ensembl chr14:20,768,015...20,783,589

G

UDP glucuronosyltransferase 2 family, polypeptide B34 like 1

multiple interactions

terpinenol-4 inhibits the reaction [Testosterone results in increased expression of UGT2B28 mRNA]

NCBI chr14:21,146,140...21,167,706
Ensembl chr14:21,145,827...21,167,704

alpha-terpineol

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

cathepsin D

increases expression

alpha-terpineol results in increased expression of CTSD mRNA

NCBI chr 1:197,527,467...197,539,343
Ensembl chr 1:197,527,467...197,539,488

G

cytochrome P450, family 4, subfamily f, polypeptide 6

multiple interactions

alpha-terpineol inhibits the reaction [Testosterone results in increased expression of CYP4F8 mRNA]

NCBI chr 7:12,030,276...12,058,020
Ensembl chr 7:12,030,301...12,057,782

G

estrogen receptor 1

multiple interactions
increases activity

alpha-terpineol binds to and results in increased activity of ESR1 protein; NCOA2 protein promotes the reaction [alpha-terpineol results in increased activity of ESR1 protein]

PMID:27633901 PMID:31393563

NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002

G

growth regulating estrogen receptor binding 1

multiple interactions
increases expression

Fulvestrant inhibits the reaction [alpha-terpineol results in increased expression of GREB1 mRNA]

NCBI chr 6:39,440,522...39,562,364
Ensembl chr 6:39,440,504...39,581,633

G

nuclear receptor coactivator 2

multiple interactions

NCOA2 protein promotes the reaction [alpha-terpineol results in increased activity of ESR1 protein]

NCBI chr 5:5,835,642...6,069,693
Ensembl chr 5:5,835,706...6,067,451

G

SEC14-like lipid binding 2

multiple interactions

alpha-terpineol inhibits the reaction [Testosterone results in increased expression of SEC14L2 mRNA]

NCBI chr14:78,973,805...78,998,480
Ensembl chr14:78,973,808...78,993,788

G

UDP glucuronosyltransferase family 2 member B15

increases metabolic processing

UGT2B15 protein results in increased metabolism of alpha-terpineol

NCBI chr14:20,768,015...20,783,599
Ensembl chr14:20,768,015...20,783,589

G

UDP glucuronosyltransferase 2 family, polypeptide B34 like 1

multiple interactions

alpha-terpineol inhibits the reaction [Testosterone results in increased expression of UGT2B28 mRNA]

NCBI chr14:21,146,140...21,167,706
Ensembl chr14:21,145,827...21,167,704

ascaridole

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ERCC excision repair 6, chromatin remodeling factor

affects response to substance

ERCC6 protein affects the susceptibility to ascaridole

NCBI chr16:7,764,983...7,835,587
Ensembl chr16:7,765,013...7,835,587

G

XPC complex subunit, DNA damage recognition and repair factor

affects response to substance

XPC protein affects the susceptibility to ascaridole

NCBI chr 4:123,993,670...124,020,922
Ensembl chr 4:123,993,666...124,021,010

carvacrol

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

acetylcholinesterase

multiple interactions
decreases activity

[propiconazole co-treated with carvacrol] results in decreased activity of ACHE protein
carvacrol results in decreased activity of ACHE protein

NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651

G

actin alpha 2, smooth muscle

multiple interactions

carvacrol inhibits the reaction [Thioacetamide results in increased expression of ACTA2 protein]

NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554

G

adiponectin, C1Q and collagen domain containing

multiple interactions

carvacrol inhibits the reaction [Poloxamer results in decreased secretion of ADIPOQ protein]; carvacrol promotes the reaction [Simvastatin inhibits the reaction [Poloxamer results in decreased secretion of ADIPOQ protein]]

NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564

G

aryl hydrocarbon receptor

multiple interactions
increases activity

[4-cymene co-treated with gamma-terpinene co-treated with Thymol co-treated with carvacrol] inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein]; [4-cymene co-treated with gamma-terpinene co-treated with Thymol co-treated with carvacrol] results in increased activity of AHR protein; carvacrol inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein]
carvacrol results in increased activity of AHR protein

NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568

G

albumin

multiple interactions

carvacrol inhibits the reaction [Thioacetamide results in decreased expression of ALB protein]

NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836

G

BCL2 associated X, apoptosis regulator

multiple interactions

carvacrol inhibits the reaction [Ethanol results in increased expression of BAX protein]

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

BCL2, apoptosis regulator

multiple interactions

carvacrol inhibits the reaction [Ethanol results in decreased expression of BCL2 protein]

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

caspase 3

increases activity
multiple interactions

carvacrol results in increased activity of CASP3 protein
carvacrol inhibits the reaction [Poloxamer results in increased expression of CASP3 protein]; carvacrol inhibits the reaction [propiconazole results in increased expression of CASP3 protein]; carvacrol inhibits the reaction [Simvastatin promotes the reaction [Poloxamer results in increased expression of CASP3 protein]]; carvacrol inhibits the reaction [Thioacetamide results in increased expression of CASP3 protein]

PMID:23146755 PMID:29071762 PMID:29852196 PMID:34155936

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

catalase

multiple interactions

carvacrol inhibits the reaction [Ethanol results in decreased expression of CAT protein]; carvacrol inhibits the reaction [Poloxamer results in decreased activity of CAT protein]; carvacrol inhibits the reaction [propiconazole results in decreased activity of CAT protein]; carvacrol promotes the reaction [Simvastatin inhibits the reaction [Poloxamer results in decreased activity of CAT protein]]
carvacrol inhibits the reaction [Diethylhexyl Phthalate results in increased activity of CAT protein]
carvacrol inhibits the reaction [Benzo(a)pyrene results in decreased activity of CAT protein]

PMID:29019276 PMID:29071762 PMID:29852196 PMID:35521929 PMID:37499997

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

creatine kinase, M-type

multiple interactions

carvacrol inhibits the reaction [Poloxamer results in increased secretion of CKM protein]; carvacrol inhibits the reaction [Simvastatin results in increased secretion of CKM protein]

NCBI chr 1:79,061,390...79,071,721
Ensembl chr 1:79,061,456...79,071,720

G

crystallin zeta

multiple interactions

carvacrol inhibits the reaction [Benzo(a)pyrene results in decreased activity of CRYZ protein]

NCBI chr 2:243,552,037...243,580,369
Ensembl chr 2:243,552,119...243,579,758

G

C-X-C motif chemokine ligand 3

multiple interactions

2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide inhibits the reaction [carvacrol inhibits the reaction [irinotecan results in increased expression of CXCL1 protein]]; carvacrol inhibits the reaction [irinotecan results in increased expression of CXCL1 protein]

NCBI chr14:17,287,727...17,289,451
Ensembl chr14:17,270,146...17,289,511

G

cytochrome P450, family 1, subfamily a, polypeptide 1

increases expression
multiple interactions

carvacrol results in increased expression of CYP1A1 mRNA
carvacrol inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

G

epidermal growth factor receptor

increases phosphorylation
multiple interactions

carvacrol results in increased phosphorylation of EGFR protein
KN 93 inhibits the reaction [carvacrol results in increased phosphorylation of EGFR protein]; TRPV3 protein affects the reaction [carvacrol results in increased phosphorylation of EGFR protein]

NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382

G

ectonucleotide pyrophosphatase/phosphodiesterase 2

multiple interactions

carvacrol inhibits the reaction [Thioacetamide results in increased expression of ENPP2 protein]

NCBI chr 7:86,202,345...86,325,050
Ensembl chr 7:86,202,350...86,324,827

G

glial fibrillary acidic protein

multiple interactions

carvacrol inhibits the reaction [propiconazole results in increased expression of GFAP protein]

NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589

G

glutamic--pyruvic transaminase

multiple interactions

carvacrol inhibits the reaction [Thioacetamide results in increased activity of GPT protein]

NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494

G

glutathione peroxidase 1

multiple interactions

carvacrol inhibits the reaction [Ethanol results in decreased expression of GPX1 protein]

NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024

G

glutathione peroxidase 4

affects binding

carvacrol binds to GPX4 protein

NCBI chr 7:9,650,186...9,652,982
Ensembl chr 7:9,650,185...9,652,982

G

5-hydroxytryptamine receptor 3A

increases activity

carvacrol results in increased activity of HTR3A protein

NCBI chr 8:49,242,018...49,254,475
Ensembl chr 8:49,242,020...49,254,389

G

interleukin 1 beta

multiple interactions

2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide inhibits the reaction [carvacrol inhibits the reaction [irinotecan results in increased expression of IL1B protein]]; carvacrol inhibits the reaction [irinotecan results in increased expression of IL1B protein]
carvacrol inhibits the reaction [Thioacetamide results in increased expression of IL1B protein]
carvacrol inhibits the reaction [Acetaminophen results in increased expression of IL1B mRNA]

PMID:26801986 PMID:27838229 PMID:34155936

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

leptin

multiple interactions

carvacrol inhibits the reaction [Poloxamer results in increased secretion of LEP protein]

NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262

G

myoglobin

multiple interactions

carvacrol inhibits the reaction [Poloxamer results in increased secretion of MB protein]

NCBI chr 7:108,759,903...108,767,134
Ensembl chr 7:108,759,904...108,767,383

G

matrix metallopeptidase 3

multiple interactions

carvacrol inhibits the reaction [Thioacetamide results in increased expression of MMP3 protein]

NCBI chr 8:4,640,397...4,653,963
Ensembl chr 8:4,640,416...4,653,961

G

matrix metallopeptidase 9

multiple interactions

carvacrol inhibits the reaction [Thioacetamide results in increased expression of MMP9 protein]

NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120

G

myeloperoxidase

multiple interactions

2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide inhibits the reaction [carvacrol inhibits the reaction [irinotecan results in increased activity of MPO protein]]; carvacrol inhibits the reaction [irinotecan results in increased activity of MPO protein]

NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819

G

NFE2 like bZIP transcription factor 2

multiple interactions

carvacrol inhibits the reaction [Thioacetamide results in decreased expression of NFE2L2 protein]

NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737

G

nuclear factor kappa B subunit 1

multiple interactions

carvacrol inhibits the reaction [irinotecan results in increased expression of NFKB1 protein]
carvacrol inhibits the reaction [Ethanol results in increased expression of NFKB1 protein]

PMID:27838229 PMID:37499997

NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404

G

nitric oxide synthase 2

multiple interactions

carvacrol inhibits the reaction [Benzo(a)pyrene results in increased expression of NOS2 protein]
carvacrol inhibits the reaction [Thioacetamide results in increased expression of NOS2 protein]

PMID:29019276 PMID:34155936

NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210

G

NADPH oxidase 1

multiple interactions
affects binding

carvacrol inhibits the reaction [Ethanol results in increased expression of NOX1 protein]
carvacrol binds to NOX1 protein

NCBI chr X:97,279,058...97,332,291
Ensembl chr X:97,279,056...97,302,236

G

NADPH oxidase 4

multiple interactions

carvacrol inhibits the reaction [Ethanol results in increased expression of NOX4 protein]

NCBI chr 1:140,900,886...141,078,844
Ensembl chr 1:140,901,097...141,077,406

G

phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha

multiple interactions
increases phosphorylation

Erlotinib Hydrochloride inhibits the reaction [carvacrol results in increased phosphorylation of PIK3CA protein]; TRPV3 protein affects the reaction [carvacrol results in increased phosphorylation of PIK3CA protein]

NCBI chr 2:115,175,275...115,249,034
Ensembl chr 2:115,174,984...115,249,032

G

prostaglandin-endoperoxide synthase 2

multiple interactions

carvacrol inhibits the reaction [Benzo(a)pyrene results in increased expression of PTGS2 protein]; carvacrol inhibits the reaction [Irinotecan results in increased expression of PTGS2 protein]
carvacrol inhibits the reaction [propiconazole results in increased expression of PTGS2 protein]

PMID:27838229 PMID:29019276 PMID:29852196

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

RELA proto-oncogene, NF-kB subunit

multiple interactions
increases phosphorylation

Erlotinib Hydrochloride inhibits the reaction [carvacrol results in increased phosphorylation of RELA protein]; TRPV3 protein affects the reaction [carvacrol results in increased phosphorylation of RELA protein]

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

transforming growth factor alpha

increases secretion
multiple interactions

carvacrol results in increased secretion of TGFA protein
KN 93 inhibits the reaction [carvacrol results in increased secretion of TGFA protein]

NCBI chr 4:118,618,043...118,700,897
Ensembl chr 4:118,618,269...118,700,894

G

transforming growth factor, beta 1

multiple interactions

carvacrol inhibits the reaction [Thioacetamide results in increased expression of TGFB1 protein]

NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847

G

tumor necrosis factor

multiple interactions

2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide inhibits the reaction [carvacrol inhibits the reaction [irinotecan results in increased expression of TNF protein]]; carvacrol inhibits the reaction [irinotecan results in increased expression of TNF protein]
carvacrol inhibits the reaction [Acetaminophen results in increased expression of TNF mRNA]
carvacrol inhibits the reaction [Ethanol results in increased expression of TNF protein]

PMID:26801986 PMID:27838229 PMID:37499997

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

transient receptor potential cation channel, subfamily A, member 1

increases activity

carvacrol results in increased activity of TRPA1 protein

PMID:16617338 PMID:22935519

NCBI chr 5:4,379,862...4,434,133
Ensembl chr 5:4,379,999...4,433,570

G

transient receptor potential cation channel, subfamily V, member 3

increases activity
affects response to substance
multiple interactions
increases response to substance

carvacrol results in increased activity of TRPV3 protein
TRPV3 protein affects the susceptibility to carvacrol
TRPV3 protein affects the reaction [carvacrol results in increased phosphorylation of EGFR protein]; TRPV3 protein affects the reaction [carvacrol results in increased phosphorylation of PIK3CA protein]; TRPV3 protein affects the reaction [carvacrol results in increased phosphorylation of RELA protein]
TRPV3 protein results in increased susceptibility to carvacrol
[carvacrol binds to and results in increased activity of TRPV3 protein] which results in increased transport of Calcium; [carvacrol results in increased activity of TRPV3 protein] which results in increased transport of Calcium; carvacrol binds to and results in increased activity of TRPV3 protein; Ruthenium Red inhibits the reaction [[carvacrol binds to and results in increased activity of TRPV3 protein] which results in increased transport of Calcium]

PMID:16617338 PMID:20086034 PMID:29658714 PMID:32535744

NCBI chr10:57,883,546...57,915,865
Ensembl chr10:57,883,546...57,913,296

G

thioredoxin 1

multiple interactions

carvacrol inhibits the reaction [Thioacetamide results in increased expression of TXN protein]

NCBI chr 5:72,712,334...72,724,564
Ensembl chr 5:72,711,933...72,724,629

G

xanthine dehydrogenase

multiple interactions

carvacrol inhibits the reaction [Benzo(a)pyrene results in increased activity of XDH protein]

NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268

carveol

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

C-type lectin domain containing 10A

multiple interactions

carveol promotes the reaction [[IL4 protein co-treated with IL13 protein] results in increased expression of CLEC10A mRNA]

NCBI chr10:54,876,244...54,880,439
Ensembl chr10:54,876,260...54,880,435

G

interleukin 13

multiple interactions

carveol promotes the reaction [[IL4 protein co-treated with IL13 protein] results in increased expression of CLEC10A mRNA]; carveol promotes the reaction [[IL4 protein co-treated with IL13 protein] results in increased expression of MRC1 mRNA]; carveol promotes the reaction [[IL4 protein co-treated with IL13 protein] results in increased phosphorylation of STAT6 protein]

NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737

G

interleukin 1 beta

multiple interactions

carveol inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 4

multiple interactions

carveol promotes the reaction [[IL4 protein co-treated with IL13 protein] results in increased expression of CLEC10A mRNA]; carveol promotes the reaction [[IL4 protein co-treated with IL13 protein] results in increased expression of MRC1 mRNA]; carveol promotes the reaction [[IL4 protein co-treated with IL13 protein] results in increased phosphorylation of STAT6 protein]

NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750

G

interleukin 6

multiple interactions

carveol inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

mannose receptor, C type 1

multiple interactions

carveol promotes the reaction [[IL4 protein co-treated with IL13 protein] results in increased expression of MRC1 mRNA]

NCBI chr17:77,249,187...77,330,857
Ensembl chr17:77,249,187...77,330,857

G

nitric oxide synthase 2

multiple interactions

carveol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]

NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210

G

ras homolog family member B

increases expression
multiple interactions

carveol results in increased expression of RHOB protein
Mevalonic Acid affects the reaction [carveol results in increased expression of RHOB protein]

NCBI chr 6:31,363,752...31,365,926
Ensembl chr 6:31,363,548...31,366,108

G

signal transducer and activator of transcription 6

multiple interactions

carveol promotes the reaction [[IL4 protein co-treated with IL13 protein] results in increased phosphorylation of STAT6 protein]

NCBI chr 7:63,480,229...63,497,551
Ensembl chr 7:63,479,642...63,498,495

G

tumor necrosis factor

multiple interactions

carveol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

UDP glucuronosyltransferase family 2 member B15

increases metabolic processing

UGT2B15 protein results in increased metabolism of carveol

NCBI chr14:20,768,015...20,783,599
Ensembl chr14:20,768,015...20,783,589

carvone

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

aryl hydrocarbon receptor

multiple interactions

[carvone co-treated with limonene] inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein]; carvone inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein]

NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568

G

cytochrome P450, family 1, subfamily a, polypeptide 1

multiple interactions
increases expression

carvone inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]
carvone results in increased expression of CYP1A1 mRNA

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

G

gamma-aminobutyric acid type A receptor subunit alpha 1

multiple interactions

carvone promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]

NCBI chr10:26,595,151...26,650,611
Ensembl chr10:26,595,160...26,650,864

G

gamma-aminobutyric acid type A receptor subunit beta 2

multiple interactions

carvone promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]

NCBI chr10:26,936,592...27,156,141
Ensembl chr10:26,936,551...27,151,251

G

gamma-aminobutyric acid type A receptor subunit gamma 2

multiple interactions

carvone promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]

NCBI chr10:26,374,693...26,463,937
Ensembl chr10:26,374,694...26,464,346

G

G protein subunit alpha 15

multiple interactions
increases response to substance

[GNA15 protein results in increased susceptibility to carvone] which results in increased activity of OR1J21 protein

NCBI chr 7:8,184,632...8,205,508
Ensembl chr 7:8,184,861...8,205,508

G

gonadotropin releasing hormone 1

increases expression
increases secretion

carvone results in increased expression of GNRH1 mRNA
carvone results in increased secretion of GNRH1 protein

NCBI chr15:41,972,482...41,976,690
Ensembl chr15:41,972,905...41,973,581
Ensembl chr15:41,972,905...41,973,581

G

hypoxia inducible factor 1 subunit alpha

multiple interactions
decreases expression

[Methotrexate co-treated with carvone] results in increased expression of HIF1A mRNA
carvone results in decreased expression of HIF1A protein
carvone results in decreased expression of HIF1A mRNA

NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261

G

integrin subunit beta 1

decreases expression
multiple interactions

carvone results in decreased expression of ITGB1 mRNA
carvone results in decreased expression of and affects the localization of ITGB1 protein
[carvone co-treated with Methotrexate] results in increased expression of ITGB1 mRNA

NCBI chr19:56,705,123...56,753,199
Ensembl chr19:56,705,171...56,753,195

G

matrix metallopeptidase 14

decreases expression

carvone results in decreased expression of MMP14 mRNA

NCBI chr15:27,887,795...27,897,020
Ensembl chr15:27,887,727...27,899,864

G

matrix metallopeptidase 2

multiple interactions
decreases expression

carvone results in decreased activity of and results in decreased secretion of MMP2 protein
carvone results in decreased expression of MMP2 mRNA

NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870

G

matrix metallopeptidase 9

decreases expression
decreases activity

carvone results in decreased expression of MMP9 mRNA
carvone results in decreased activity of MMP9 protein

NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120

G

cytochrome p450 oxidoreductase

increases response to substance

POR protein results in increased susceptibility to carvone analog

NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245

G

protein tyrosine kinase 2

decreases phosphorylation

carvone results in decreased phosphorylation of PTK2 protein

NCBI chr 7:105,126,725...105,331,848
Ensembl chr 7:105,126,728...105,331,783

G

ras homolog family member A

increases expression
multiple interactions

carvone results in increased expression of RHOA protein
Mevalonic Acid affects the reaction [carvone results in increased expression of RHOA protein]

NCBI chr 8:108,991,926...109,025,746
Ensembl chr 8:108,991,954...109,025,746

G

ras homolog family member B

multiple interactions
increases expression

Mevalonic Acid affects the reaction [carvone results in increased expression of RHOB protein]

NCBI chr 6:31,363,752...31,365,926
Ensembl chr 6:31,363,548...31,366,108

G

TIMP metallopeptidase inhibitor 1

decreases expression

carvone results in decreased expression of TIMP1 mRNA

NCBI chr X:1,212,969...1,217,714
Ensembl chr X:1,212,972...1,217,664

G

vascular endothelial growth factor A

multiple interactions
decreases expression

[Methotrexate co-treated with carvone] results in increased expression of VEGFA mRNA
carvone results in decreased expression of VEGFA mRNA; carvone results in decreased expression of VEGFA protein

NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641

menthone

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

gamma-aminobutyric acid type A receptor subunit alpha 1

multiple interactions

menthone promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]

NCBI chr10:26,595,151...26,650,611
Ensembl chr10:26,595,160...26,650,864

G

gamma-aminobutyric acid type A receptor subunit beta 2

multiple interactions

menthone promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]

NCBI chr10:26,936,592...27,156,141
Ensembl chr10:26,936,551...27,151,251

G

gamma-aminobutyric acid type A receptor subunit gamma 2

multiple interactions

menthone promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]

NCBI chr10:26,374,693...26,463,937
Ensembl chr10:26,374,694...26,464,346

p-menth-4(8)-en-3-one

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

tumor necrosis factor

increases expression

pulegone results in increased expression of TNF mRNA

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

p-menthan-3-ol

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

apoptosis antagonizing transcription factor

increases expression

Menthol results in increased expression of DED mRNA

NCBI chr10:69,299,029...69,392,207
Ensembl chr10:69,299,037...69,392,201

G

apoptosis-associated tyrosine kinase

decreases expression

Menthol results in decreased expression of AATK mRNA

NCBI chr10:105,290,752...105,327,219
Ensembl chr10:105,291,585...105,327,112

G

ATP binding cassette subfamily C member 2

increases expression

Menthol results in increased expression of ABCC2 mRNA

NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238

G

ATP binding cassette subfamily C member 3

increases expression

Menthol results in increased expression of ABCC3 mRNA

NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595

G

actin, beta

decreases expression

Menthol results in decreased expression of ACTB protein

NCBI chr12:11,663,112...11,666,697
Ensembl chr12:11,663,109...11,672,877

G

ADAM metallopeptidase domain 17

increases expression

Menthol results in increased expression of ADAM17 mRNA

NCBI chr 6:40,872,936...40,920,700
Ensembl chr 6:40,872,856...40,920,639

G

angiotensin II receptor, type 2

decreases expression

Menthol results in decreased expression of AGTR2 mRNA

NCBI chr X:112,119,876...112,124,060
Ensembl chr X:112,120,228...112,124,057

G

allograft inflammatory factor 1

increases expression

Menthol results in increased expression of AIF1 mRNA

NCBI chr20:3,646,784...3,652,670
Ensembl chr20:3,646,777...3,652,668

G

apoptosis inducing factor, mitochondria associated 1

decreases expression

Menthol results in decreased expression of AIFM1 mRNA

NCBI chr X:127,650,223...127,689,356
Ensembl chr X:127,650,226...127,689,256

G

AKT serine/threonine kinase 1

decreases expression

Menthol results in decreased expression of AKT1 mRNA

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

AKT serine/threonine kinase 2

decreases expression

Menthol results in decreased expression of AKT2 mRNA

NCBI chr 1:82,877,228...82,933,828
Ensembl chr 1:82,883,547...82,933,817

G

AKT serine/threonine kinase 3

increases expression

Menthol results in increased expression of AKT3 mRNA

NCBI chr13:88,943,708...89,225,831
Ensembl chr13:88,946,091...89,225,708

G

annexin A5

increases expression

Menthol results in increased expression of ANXA5 protein

NCBI chr 2:119,314,007...119,344,703
Ensembl chr 2:119,314,007...119,353,369

G

apoptotic peptidase activating factor 1

increases expression

Menthol results in increased expression of APAF1 mRNA

NCBI chr 7:25,494,143...25,579,540
Ensembl chr 7:25,494,609...25,579,540

G

APC regulator of WNT signaling pathway

decreases expression

Menthol results in decreased expression of APC mRNA

NCBI chr18:25,828,558...25,925,511
Ensembl chr18:25,864,222...25,922,696

G

apolipoprotein A1

multiple interactions

[Tobacco Smoke Pollution co-treated with Menthol] results in decreased expression of and results in decreased secretion of APOA1 protein

NCBI chr 8:46,527,251...46,529,035
Ensembl chr 8:46,527,144...46,529,035

G

amyloid beta precursor protein

decreases expression

Menthol results in decreased expression of APP mRNA

NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561

G

AT-rich interaction domain 4A

increases expression

Menthol results in increased expression of ARID4A mRNA

NCBI chr 6:89,522,459...89,593,868
Ensembl chr 6:89,522,442...89,593,510

G

autophagy related 5

increases expression

Menthol results in increased expression of ATG5 mRNA

NCBI chr20:47,798,217...47,889,216
Ensembl chr20:47,798,290...47,889,209

G

ATM serine/threonine kinase

decreases expression

Menthol results in decreased expression of ATM mRNA

NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437

G

ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3

increases expression

Menthol results in increased expression of ATP2A3 mRNA

NCBI chr10:57,581,742...57,612,758
Ensembl chr10:57,582,128...57,612,748

G

BRISC and BRCA1 A complex member 2

decreases expression

Menthol results in decreased expression of BRE mRNA

NCBI chr 6:24,369,021...24,788,416
Ensembl chr 6:24,369,022...24,833,951

G

BCL2-associated agonist of cell death

increases expression

Menthol results in increased expression of BAD mRNA

NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823

G

BAG cochaperone 1

decreases expression

Menthol results in decreased expression of BAG1 mRNA

NCBI chr 5:56,068,494...56,081,075
Ensembl chr 5:56,068,494...56,081,075

G

BAG cochaperone 2

decreases expression

Menthol results in decreased expression of BAG2 mRNA

NCBI chr 9:35,970,033...35,980,677
Ensembl chr 9:35,970,033...35,980,721

G

BAG cochaperone 3

increases expression

Menthol results in increased expression of BAG3 mRNA

NCBI chr 1:183,103,038...183,126,862
Ensembl chr 1:183,102,871...183,126,858

G

BAG cochaperone 4

increases expression

Menthol results in increased expression of BAG4 mRNA

NCBI chr16:66,288,678...66,305,893
Ensembl chr16:66,288,678...66,308,663

G

BAG cochaperone 5

increases expression

Menthol results in increased expression of BAG5 mRNA

NCBI chr 6:130,768,467...130,772,122
Ensembl chr 6:130,768,141...130,772,970

G

BCL2-antagonist/killer 1

increases expression

Menthol results in increased expression of BAK1 mRNA

NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264

G

BCL2 associated X, apoptosis regulator

decreases expression

Menthol results in decreased expression of BAX mRNA

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

BCL10, immune signaling adaptor

decreases expression

Menthol results in decreased expression of BCL10 mRNA

NCBI chr 2:234,840,880...234,850,520
Ensembl chr 2:234,840,858...234,850,523

G

BCL2, apoptosis regulator

decreases expression

Menthol results in decreased expression of BCL2 mRNA

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

Bcl2-like 10

increases expression

Menthol results in increased expression of BCL2L10 mRNA

NCBI chr 8:76,107,326...76,113,373
Ensembl chr 8:76,107,326...76,113,367

G

Bcl2 like 12

decreases expression

Menthol results in decreased expression of BCL2L12 mRNA

NCBI chr 1:95,472,272...95,480,991
Ensembl chr 1:95,472,272...95,480,991

G

Bcl2-like 14

increases expression

Menthol results in increased expression of BCL2L14 mRNA

NCBI chr 4:167,217,561...167,258,723
Ensembl chr 4:167,219,871...167,258,086

G

Bcl2-like 2

increases expression

Menthol results in increased expression of BCL2L2 mRNA

NCBI chr15:28,346,449...28,361,627
Ensembl chr15:28,356,807...28,361,624

G

BCL3, transcription coactivator

increases expression

Menthol results in increased expression of BCL3 mRNA

NCBI chr 1:79,471,368...79,485,908
Ensembl chr 1:79,471,369...79,485,607

G

BAF chromatin remodeling complex subunit BCL7B

increases expression

Menthol results in increased expression of BCL7B mRNA

NCBI chr12:21,496,860...21,510,079
Ensembl chr12:21,496,856...21,510,202

G

beclin 1

increases expression

Menthol results in increased expression of BECN1 mRNA

NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742

G

brain expressed X-linked 3

increases expression

Menthol results in increased expression of BEX3 mRNA

NCBI chr X:99,273,270...99,274,799
Ensembl chr X:99,273,161...99,274,800

G

bifunctional apoptosis regulator

decreases expression

Menthol results in decreased expression of BFAR mRNA

NCBI chr10:1,552,019...1,585,040
Ensembl chr10:1,552,072...1,585,038

G

BH3 interacting domain death agonist

increases expression

Menthol results in increased expression of BID mRNA

NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720

G

BCL2-interacting killer

increases expression

Menthol results in increased expression of BIK mRNA

NCBI chr 7:114,672,277...114,691,296
Ensembl chr 7:114,672,277...114,691,296

G

baculoviral IAP repeat-containing 3

decreases expression

Menthol results in decreased expression of BIRC3 mRNA

NCBI chr 8:5,000,844...5,028,470
Ensembl chr 8:5,000,845...5,015,802

G

BLK proto-oncogene, Src family tyrosine kinase

decreases expression

Menthol results in decreased expression of BLK mRNA

NCBI chr15:37,626,746...37,665,053
Ensembl chr15:37,627,039...37,665,031

G

Bcl2 modifying factor

decreases expression

Menthol results in decreased expression of BMF mRNA

NCBI chr 3:105,499,534...105,520,159
Ensembl chr 3:105,499,538...105,520,145

G

BCL2 interacting protein 2

increases expression

Menthol results in increased expression of BNIP2 mRNA

NCBI chr 8:70,640,436...70,661,782
Ensembl chr 8:70,640,445...70,675,590

G

BCL2 interacting protein 3

decreases expression

Menthol results in decreased expression of BNIP3 mRNA

NCBI chr 1:193,708,164...193,725,348
Ensembl chr 1:193,708,167...193,725,359

G

BCL2 interacting protein 3 like

decreases expression

Menthol results in decreased expression of BNIP3L mRNA

NCBI chr15:41,174,594...41,197,730
Ensembl chr15:41,174,594...41,197,803

G

BCL2 family apoptosis regulator BOK

decreases expression

Menthol results in decreased expression of BOK mRNA

NCBI chr 9:94,223,493...94,234,476
Ensembl chr 9:94,223,389...94,234,476

G

calcium voltage-gated channel subunit alpha1 B

decreases expression

Menthol results in decreased expression of CACNA1B mRNA

NCBI chr 3:7,380,892...7,546,104
Ensembl chr 3:7,380,922...7,546,091

G

calcium voltage-gated channel subunit alpha1 D

decreases expression

Menthol results in decreased expression of CACNA1D mRNA

NCBI chr16:5,227,157...5,521,163
Ensembl chr16:5,228,306...5,668,215

G

calcium voltage-gated channel subunit alpha1 E

decreases expression

Menthol results in decreased expression of CACNA1E mRNA

NCBI chr13:66,574,659...67,063,443
Ensembl chr13:66,581,920...66,894,450

G

calcium voltage-gated channel subunit alpha1 F

increases expression

Menthol results in increased expression of CACNA1F mRNA

NCBI chr X:14,868,096...14,896,413
Ensembl chr X:14,868,024...14,896,413

G

calcium voltage-gated channel subunit alpha1 G

increases expression

Menthol results in increased expression of CACNA1G mRNA

NCBI chr10:79,354,998...79,422,960
Ensembl chr10:79,355,008...79,422,752

G

calcium voltage-gated channel subunit alpha1 H

decreases expression

Menthol results in decreased expression of CACNA1H mRNA

NCBI chr10:14,390,104...14,448,204
Ensembl chr10:14,390,113...14,448,376

G

calcium voltage-gated channel auxiliary subunit alpha2delta 2

decreases expression

Menthol results in decreased expression of CACNA2D2 mRNA

NCBI chr 8:108,072,208...108,203,516
Ensembl chr 8:108,072,454...108,203,173

G

calcium voltage-gated channel auxiliary subunit beta 1

decreases expression

Menthol results in decreased expression of CACNB1 mRNA

NCBI chr10:82,998,182...83,018,838
Ensembl chr10:82,998,182...83,018,694

G

calcium voltage-gated channel auxiliary subunit beta 2

decreases expression

Menthol results in decreased expression of CACNB2 mRNA

NCBI chr17:77,564,630...77,910,000
Ensembl chr17:77,564,460...77,909,106

G

calcium voltage-gated channel auxiliary subunit beta 4

decreases expression

Menthol results in decreased expression of CACNB4 mRNA

NCBI chr 3:36,906,771...37,169,165
Ensembl chr 3:36,910,427...37,168,944

G

calpain 1

increases expression

Menthol results in increased expression of CAPN1 mRNA

NCBI chr 1:203,275,912...203,300,848
Ensembl chr 1:203,277,344...203,300,177

G

calpain 11

decreases expression

Menthol results in decreased expression of CAPN11 mRNA

NCBI chr 9:15,344,059...15,365,604
Ensembl chr 9:15,344,089...15,365,601

G

calpain 6

decreases expression

Menthol results in decreased expression of CAPN6 mRNA

NCBI chr X:107,380,774...107,405,489
Ensembl chr X:107,380,774...107,405,489

G

calpain 9

decreases expression

Menthol results in decreased expression of CAPN9 mRNA

NCBI chr19:52,549,448...52,586,413
Ensembl chr19:52,549,448...52,586,413

G

caspase recruitment domain family, member 10

decreases expression

Menthol results in decreased expression of CARD10 mRNA

NCBI chr 7:110,330,460...110,371,551
Ensembl chr 7:110,330,408...110,359,224

G

caspase recruitment domain family, member 11

decreases expression

Menthol results in decreased expression of CARD11 mRNA

NCBI chr12:13,621,140...13,758,115
Ensembl chr12:13,621,087...13,758,112

G

caspase recruitment domain family, member 14

decreases expression

Menthol results in decreased expression of CARD14 mRNA

NCBI chr10:104,572,059...104,601,606
Ensembl chr10:104,566,424...104,601,905

G

caspase recruitment domain family, member 6

decreases expression

Menthol results in decreased expression of CARD6 mRNA

NCBI chr 2:54,194,343...54,206,902
Ensembl chr 2:54,195,739...54,206,846

G

caspase recruitment domain family, member 9

increases expression

Menthol results in increased expression of CARD9 mRNA

NCBI chr 3:9,171,814...9,180,310
Ensembl chr 3:9,171,815...9,180,237

G

caspase 1

decreases expression

Menthol results in decreased expression of CASP1 mRNA

NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383

G

caspase 14

increases expression

Menthol results in increased expression of CASP14 mRNA

NCBI chr 7:10,929,759...10,932,591
Ensembl chr 7:10,926,725...10,933,405

G

caspase 2

decreases expression

Menthol results in decreased expression of CASP2 mRNA

NCBI chr 4:71,149,632...71,167,388
Ensembl chr 4:71,149,669...71,167,379

G

caspase 3

increases activity
increases expression

Menthol results in increased activity of CASP3 protein
Menthol results in increased expression of CASP3 mRNA

PMID:21472860 PMID:26760959

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 4

increases expression

Menthol results in increased expression of CASP4 mRNA

NCBI chr 8:2,599,017...2,635,097
Ensembl chr 8:2,598,876...2,635,092

G

caspase 6

decreases expression

Menthol results in decreased expression of CASP6 mRNA

NCBI chr 2:218,466,063...218,478,503
Ensembl chr 2:218,466,076...218,478,502

G

caspase 7

increases expression

Menthol results in increased expression of CASP7 mRNA

NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729

G

caspase 8

decreases expression

Menthol results in decreased expression of CASP8 mRNA

NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542

G

caspase 8 associated protein 2

decreases expression

Menthol results in decreased expression of CASP8AP2 mRNA

NCBI chr 5:47,014,501...47,052,276
Ensembl chr 5:47,014,667...47,052,275

G

caspase 9

increases expression

Menthol results in increased expression of CASP9 mRNA

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

G

caveolin 1

increases expression

Menthol results in increased expression of CAV1 mRNA

NCBI chr 4:45,640,624...45,673,708
Ensembl chr 4:45,634,918...45,673,705

G

Cbl proto-oncogene

decreases expression

Menthol results in decreased expression of CBL mRNA

NCBI chr 8:44,487,824...44,571,620
Ensembl chr 8:44,489,410...44,571,176

G

Cbl proto-oncogene B

decreases expression

Menthol results in decreased expression of CBLB mRNA

NCBI chr11:48,589,878...48,756,940
Ensembl chr11:48,592,703...48,756,839

G

chromobox 4

increases expression

Menthol results in increased expression of CBX4 mRNA

NCBI chr10:104,337,140...104,343,210
Ensembl chr10:104,336,876...104,356,706

G

cyclin D1

decreases expression

Menthol results in decreased expression of CCND1 mRNA

NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602

G

cyclin G1

decreases expression

Menthol results in decreased expression of CCNG1 mRNA

NCBI chr10:25,176,231...25,182,604
Ensembl chr10:25,176,234...25,181,641

G

chaperonin containing TCP1 subunit 2

decreases expression

Menthol results in decreased expression of CCT2 protein

NCBI chr 7:52,692,725...52,705,478
Ensembl chr 7:52,692,725...52,706,944

G

CD27 molecule

increases expression

Menthol results in increased expression of CD27 mRNA

NCBI chr 4:158,030,700...158,035,862
Ensembl chr 4:158,030,703...158,035,592

G

CD40 molecule

decreases expression

Menthol results in decreased expression of CD40 mRNA

NCBI chr 3:153,790,372...153,805,279
Ensembl chr 3:153,790,449...153,805,534

G

CD40 ligand

decreases expression

Menthol results in decreased expression of CD40LG mRNA

NCBI chr X:135,127,052...135,138,768
Ensembl chr X:135,126,969...135,138,306

G

Cd70 molecule

increases expression

Menthol results in increased expression of CD70 mRNA

NCBI chr 9:2,006,563...2,009,715
Ensembl chr 9:2,006,563...2,009,715

G

cadherin 1

increases expression

Menthol results in increased expression of CDH1 mRNA

NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775

G

cadherin 3

increases expression

Menthol results in increased expression of CDH3 mRNA

NCBI chr19:34,393,596...34,444,084
Ensembl chr19:34,393,727...34,444,084

G

cyclin-dependent kinase 13

increases expression

Menthol results in increased expression of CDK13 mRNA

NCBI chr17:47,251,145...47,344,675
Ensembl chr17:47,251,163...47,341,721

G

cyclin-dependent kinase 5 regulatory subunit 2

increases expression

Menthol results in increased expression of CDK5R2 mRNA

NCBI chr 9:76,416,251...76,417,719
Ensembl chr 9:76,416,062...76,418,344

G

cyclin-dependent kinase inhibitor 1A

decreases expression

Menthol results in decreased expression of CDKN1A mRNA

NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585

G

cyclin-dependent kinase inhibitor 2A

increases expression

Menthol results in increased expression of CDKN2A mRNA

NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149

G

cyclin dependent kinase inhibitor 2D

decreases expression

Menthol results in decreased expression of CDKN2D mRNA

NCBI chr 8:19,831,874...19,834,640
Ensembl chr 8:19,831,866...19,834,674

G

CUGBP, Elav-like family member 2

increases expression

Menthol results in increased expression of CELF2 mRNA

NCBI chr17:70,904,462...71,729,072
Ensembl chr17:71,210,853...71,728,333

G

carboxylesterase 1F

multiple interactions

[Tobacco Smoke Pollution co-treated with Menthol] results in decreased expression of CES1F protein

NCBI chr19:13,796,623...13,822,113
Ensembl chr19:13,796,623...13,912,035

G

CASP8 and FADD-like apoptosis regulator

increases expression

Menthol results in increased expression of CFLAR mRNA

NCBI chr 9:60,185,338...60,236,173
Ensembl chr 9:60,185,452...60,237,034

G

chitinase 3 like 1

multiple interactions

[Tobacco Smoke Pollution co-treated with Menthol] results in increased expression of CHI3L1 protein

NCBI chr13:45,641,802...45,649,787
Ensembl chr13:45,641,802...45,649,787

G

cell death-inducing DFFA-like effector a

increases expression

Menthol results in increased expression of CIDEA mRNA

NCBI chr18:60,894,917...60,920,485
Ensembl chr18:60,894,874...60,920,481

G

cell death-inducing DFFA-like effector b

increases expression

Menthol results in increased expression of CIDEB mRNA

NCBI chr15:29,252,208...29,256,482
Ensembl chr15:29,252,213...29,256,605

G

clusterin

decreases expression

Menthol results in decreased expression of CLU mRNA

NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315

G

cannabinoid receptor 1

decreases expression

Menthol results in decreased expression of CNR1 mRNA

NCBI chr 5:48,408,543...48,436,099
Ensembl chr 5:48,408,574...48,435,099

G

cannabinoid receptor 2

decreases expression

Menthol results in decreased expression of CNR2 mRNA

NCBI chr 5:148,125,222...148,151,548
Ensembl chr 5:148,125,604...148,151,548

G

C-reactive protein

multiple interactions

[Tobacco Smoke Pollution co-treated with Menthol] results in increased expression of and results in increased secretion of CRP protein

NCBI chr13:85,135,384...85,175,178
Ensembl chr13:85,124,977...85,175,178

G

chromosome segregation 1 like

increases expression

Menthol results in increased expression of CSE1L mRNA

NCBI chr 3:155,641,104...155,678,866
Ensembl chr 3:155,641,166...155,678,865

G

catenin beta 1

decreases expression

Menthol results in decreased expression of CTNNB1 mRNA

NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111

G

C-X-C motif chemokine ligand 2

multiple interactions

[Tobacco Smoke Pollution co-treated with Menthol] results in decreased expression of and results in decreased secretion of CXCL2 protein

NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075

G

C-X-C motif chemokine ligand 6

multiple interactions

[Tobacco Smoke Pollution co-treated with Menthol] results in increased expression of and results in increased secretion of CXCL6 protein

NCBI chr14:17,310,790...17,312,250
Ensembl chr14:17,310,426...17,313,093

G

cytochrome c-1

decreases expression

Menthol results in decreased expression of CYC1 mRNA

NCBI chr 7:108,067,106...108,069,483
Ensembl chr 7:108,067,115...108,069,479

G

cytochrome P450, family 2, subfamily b, polypeptide 3

multiple interactions
increases expression

Menthol inhibits the reaction [CYP2B6 protein results in increased hydrolysis of Bupropion]
Menthol results in increased expression of CYP2B10 mRNA

PMID:18611395 PMID:24594507

NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143

G

cytochrome P450, family 2, subfamily C, polypeptide 6

increases expression

Menthol results in increased expression of CYP2C29 mRNA

NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596

G

cytochrome P450, family 3, subfamily a, polypeptide 2

increases expression

Menthol results in increased expression of CYP3A4 mRNA

NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008

G

defender against cell death 1

decreases expression

Menthol results in decreased expression of DAD1 mRNA

NCBI chr15:27,677,286...27,697,120
Ensembl chr15:27,677,268...27,697,347

G

death-associated protein

decreases expression

Menthol results in decreased expression of DAP mRNA

NCBI chr 2:82,199,206...82,251,771
Ensembl chr 2:82,199,280...82,251,752

G

death associated protein 3

decreases expression

Menthol results in decreased expression of DAP3 mRNA

NCBI chr 2:174,319,341...174,347,489
Ensembl chr 2:174,318,983...174,346,461

G

death associated protein kinase 1

decreases expression

Menthol results in decreased expression of DAPK1 mRNA

NCBI chr17:3,930,223...4,090,991
Ensembl chr17:3,930,213...4,090,991

G

death-associated protein kinase 2

decreases expression

Menthol results in decreased expression of DAPK2 mRNA

NCBI chr 8:66,706,536...66,825,567
Ensembl chr 8:66,706,609...66,825,567

G

death-associated protein kinase 3

decreases expression

Menthol results in decreased expression of DAPK3 mRNA

NCBI chr 7:8,524,182...8,532,552
Ensembl chr 7:8,524,183...8,532,558

G

death-domain associated protein

decreases expression

Menthol results in decreased expression of DAXX mRNA

NCBI chr20:4,970,090...4,976,145
Ensembl chr20:4,970,092...4,975,843

G

DEAD-box helicase 41

increases expression

Menthol results in increased expression of ABS mRNA

NCBI chr17:9,102,926...9,108,415
Ensembl chr17:9,103,010...9,108,415

G

defensin beta 4

multiple interactions

[Tobacco Smoke Pollution co-treated with Menthol] results in increased expression of DEFB4 protein

NCBI chr16:70,650,472...70,653,665
Ensembl chr16:70,650,472...70,653,665

G

DNA fragmentation factor subunit alpha

increases expression

Menthol results in increased expression of DFFA mRNA

NCBI chr 5:159,540,715...159,553,639
Ensembl chr 5:159,540,715...159,553,633

G

DNA fragmentation factor subunit beta

increases expression

Menthol results in increased expression of DFFB mRNA

NCBI chr 5:164,522,446...164,534,733
Ensembl chr 5:164,522,463...164,534,628

G

diablo, IAP-binding mitochondrial protein

increases expression

Menthol results in increased expression of DIABLO mRNA

NCBI chr12:33,055,784...33,070,401
Ensembl chr12:33,055,263...33,070,387

G

deoxyribonuclease 1

decreases expression

Menthol results in decreased expression of DNASE1 mRNA

NCBI chr10:11,498,930...11,505,151
Ensembl chr10:11,498,931...11,501,869

G

deoxyribonuclease 1L3

increases expression

Menthol results in increased expression of DNASE1L3 mRNA

NCBI chr15:16,922,335...16,948,322
Ensembl chr15:16,922,335...16,948,317

G

deoxyribonuclease 2, lysosomal

decreases expression

Menthol results in decreased expression of DNASE2 mRNA

NCBI chr19:23,244,656...23,247,376
Ensembl chr19:23,244,664...23,247,376

G

dedicator of cyto-kinesis 1

decreases expression

Menthol results in decreased expression of DOCK1 mRNA

NCBI chr 1:189,467,143...189,983,777
Ensembl chr 1:189,467,143...189,983,768

G

double PHD fingers 2

decreases expression

Menthol results in decreased expression of DPF2 mRNA

NCBI chr 1:203,183,674...203,199,037
Ensembl chr 1:203,183,686...203,198,983

G

E2F transcription factor 1

increases expression

Menthol results in increased expression of E2F1 mRNA

NCBI chr 3:143,064,535...143,075,362
Ensembl chr 3:143,049,478...143,075,361

G

E2F transcription factor 3

decreases expression

Menthol results in decreased expression of E2F3 mRNA

NCBI chr17:34,601,756...34,679,139
Ensembl chr17:34,601,830...34,676,253

G

E2F transcription factor 5

decreases expression

Menthol results in decreased expression of E2F5 mRNA

NCBI chr 2:86,997,331...87,012,908
Ensembl chr 2:86,997,332...87,012,990

G

eukaryotic translation elongation factor 1 alpha 1

decreases expression

Menthol results in decreased expression of EEF1A1 mRNA

NCBI chr 8:79,341,554...79,344,784
Ensembl chr 8:79,341,557...79,344,839

G

eukaryotic translation elongation factor 1 gamma

decreases expression

Menthol results in decreased expression of EEF1G protein

NCBI chr 1:205,860,713...205,871,319
Ensembl chr 1:205,860,698...205,872,382

G

EI24, autophagy associated transmembrane protein

decreases expression

Menthol results in decreased expression of EI24 mRNA

NCBI chr 8:36,494,289...36,510,653
Ensembl chr 8:36,494,289...36,510,571

G

eukaryotic translation initiation factor 4, gamma 2

decreases expression

Menthol results in decreased expression of EIF4G2 mRNA

NCBI chr 1:165,181,433...165,193,583
Ensembl chr 1:165,181,434...165,193,588

G

epithelial membrane protein 3

increases expression

Menthol results in increased expression of EMP3 mRNA

NCBI chr 1:96,388,651...96,391,946
Ensembl chr 1:96,388,652...96,391,988

G

E1A binding protein p300

decreases expression

Menthol results in decreased expression of EP300 mRNA

NCBI chr 7:113,108,476...113,178,529
Ensembl chr 7:113,106,247...113,136,088
Ensembl chr 7:113,106,247...113,136,088

G

ERCC excision repair 2, TFIIH core complex helicase subunit

increases expression

Menthol results in increased expression of ERCC2 mRNA

NCBI chr 1:79,033,342...79,047,102
Ensembl chr 1:79,033,326...79,047,102

G

ERCC excision repair 3, TFIIH core complex helicase subunit

increases expression

Menthol results in increased expression of ERCC3 mRNA

NCBI chr18:23,883,613...23,914,326
Ensembl chr18:23,883,580...23,914,329

G

Fas associated via death domain

decreases expression

Menthol results in decreased expression of FADD mRNA

NCBI chr 1:199,743,200...199,745,746
Ensembl chr 1:199,739,994...199,745,653

G

Fas associated factor 1

decreases expression

Menthol results in decreased expression of FAF1 mRNA

NCBI chr 5:124,426,032...124,790,014
Ensembl chr 5:124,426,062...124,789,977

G

Fas cell surface death receptor

decreases expression

Menthol results in decreased expression of FAS mRNA

NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591

G

Fas ligand

increases expression

Menthol results in increased expression of FASLG mRNA

NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215

G

Fas-activated serine/threonine kinase

decreases expression

Menthol results in decreased expression of FASTK mRNA

NCBI chr 4:10,732,273...10,736,332
Ensembl chr 4:10,732,256...10,737,430

G

Fc mu receptor

increases expression

Menthol results in increased expression of FCMR mRNA

NCBI chr13:42,337,363...42,351,706
Ensembl chr13:42,337,414...42,351,653

G

Fos proto-oncogene, AP-1 transcription factor subunit

increases expression

Menthol results in increased expression of FOS protein

NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036

G

forkhead box K2

increases expression

Menthol results in increased expression of FOXK2 mRNA

NCBI chr10:106,542,643...106,592,569
Ensembl chr10:106,542,566...106,592,563

G

GRB2-associated binding protein 1

increases expression

Menthol results in increased expression of GAB1 mRNA

NCBI chr19:27,131,262...27,239,236
Ensembl chr19:27,131,262...27,239,236

G

gamma-aminobutyric acid type A receptor subunit alpha 1

multiple interactions

Menthol promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]

NCBI chr10:26,595,151...26,650,611
Ensembl chr10:26,595,160...26,650,864

G

gamma-aminobutyric acid type A receptor subunit beta 2

multiple interactions

Menthol promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]

NCBI chr10:26,936,592...27,156,141
Ensembl chr10:26,936,551...27,151,251

G

gamma-aminobutyric acid type A receptor subunit gamma 2

multiple interactions

Menthol promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]

NCBI chr10:26,374,693...26,463,937
Ensembl chr10:26,374,694...26,464,346

G

growth arrest and DNA-damage-inducible, alpha

decreases expression

Menthol results in decreased expression of GADD45A mRNA

NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115

G

glyceraldehyde-3-phosphate dehydrogenase

increases expression

Menthol results in increased expression of GAPDH mRNA

NCBI chr 4:157,962,312...157,967,158
Ensembl chr 4:157,962,343...157,966,235

G

glyoxalase 1

increases expression

Menthol results in increased expression of GLO1 protein

NCBI chr20:8,663,617...8,681,661
Ensembl chr20:8,662,801...8,681,649

G

growth factor receptor bound protein 2

decreases expression

Menthol results in decreased expression of GRB2 mRNA

NCBI chr10:100,881,404...100,949,193
Ensembl chr10:100,869,718...100,949,309

G

glutamate ionotropic receptor delta type subunit 2

increases expression

Menthol results in increased expression of GRID2 mRNA

NCBI chr 4:92,415,019...93,892,472
Ensembl chr 4:92,415,230...93,889,355

G

glutamate ionotropic receptor NMDA type subunit 2C

decreases expression

Menthol results in decreased expression of GRIN2C mRNA

NCBI chr10:100,488,430...100,507,083
Ensembl chr10:100,488,431...100,506,427

G

gelsolin

decreases expression

Menthol results in decreased expression of GSN mRNA

NCBI chr 3:18,585,166...18,638,404
Ensembl chr 3:18,585,172...18,638,402

G

glutathione S-transferase omega 1

increases expression

Menthol results in increased expression of GSTO1 mRNA

NCBI chr 1:246,721,089...246,731,228
Ensembl chr 1:246,721,221...246,731,468

G

granzyme B

increases expression

Menthol results in increased expression of GZMB mRNA

NCBI chr15:30,343,352...30,346,814
Ensembl chr15:30,173,603...30,346,814

G

hematopoietic cell signal transducer

decreases expression

Menthol results in decreased expression of HCST mRNA

NCBI chr 1:85,676,976...85,679,083
Ensembl chr 1:85,676,979...85,679,012

G

heterogeneous nuclear ribonucleoprotein U-like 1

increases expression

Menthol results in increased expression of HNRNPUL1 mRNA

NCBI chr 1:81,228,404...81,264,121
Ensembl chr 1:81,228,404...81,262,592

G

heat shock protein 90 alpha family class B member 1

decreases expression

Menthol results in decreased expression of HSP90AB1 mRNA; Menthol results in decreased expression of HSP90AB1 protein

NCBI chr 9:15,432,986...15,438,358
Ensembl chr 9:15,433,691...15,438,488

G

heat shock protein 90 beta family member 1

decreases expression

Menthol results in decreased expression of HSP90B1 mRNA; Menthol results in decreased expression of HSP90B1 protein

NCBI chr 7:21,110,431...21,124,762
Ensembl chr 7:21,110,457...21,124,788

G

heat shock protein family A (Hsp70) member 5

increases expression

Menthol results in increased expression of HSPA5 mRNA; Menthol results in increased expression of HSPA5 protein

NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891

G

heat shock protein family D (Hsp60) member 1

decreases expression

Menthol results in decreased expression of HSPD1 mRNA

NCBI chr 9:56,579,195...56,590,011
Ensembl chr 9:56,579,201...56,589,662

G

heat shock protein family E (Hsp10) member 1

decreases expression

Menthol results in decreased expression of HSPE1 mRNA

NCBI chr 9:56,589,912...56,593,000
Ensembl chr 9:56,589,789...56,593,089

G

HIV-1 Tat interactive protein 2

increases expression

Menthol results in increased expression of HTATIP2 mRNA

NCBI chr 1:99,473,411...99,488,632
Ensembl chr 1:99,469,245...99,488,629

G

huntingtin

decreases expression

Menthol results in decreased expression of HTT mRNA

NCBI chr14:75,845,836...75,996,094
Ensembl chr14:75,845,836...75,995,070

G

insulin-like growth factor 1

decreases expression

Menthol results in decreased expression of IGF1 mRNA

NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296

G

insulin-like growth factor 1 receptor

decreases expression

Menthol results in decreased expression of IGF1R mRNA

NCBI chr 1:121,549,831...121,838,548
Ensembl chr 1:121,550,743...121,831,777

G

insulin-like growth factor 2 receptor

increases expression

Menthol results in increased expression of IGF2R mRNA

NCBI chr 1:47,979,109...48,067,501
Ensembl chr 1:47,979,109...48,067,501

G

insulin-like growth factor binding protein, acid labile subunit

increases expression

Menthol results in increased expression of IGFALS mRNA

NCBI chr10:13,897,468...13,903,920
Ensembl chr10:13,898,395...13,902,677

G

insulin-like growth factor binding protein 2

increases expression

Menthol results in increased expression of IGFBP2 mRNA

NCBI chr 9:74,415,574...74,442,945
Ensembl chr 9:74,415,546...74,442,937

G

insulin-like growth factor binding protein 4

decreases expression

Menthol results in decreased expression of IGFBP4 mRNA

NCBI chr10:83,995,253...84,007,272
Ensembl chr10:83,989,591...84,007,225

G

insulin-like growth factor binding protein 5

decreases expression

Menthol results in decreased expression of IGFBP5 mRNA

NCBI chr 9:74,452,371...74,464,953
Ensembl chr 9:74,448,382...74,465,156

G

insulin-like growth factor binding protein 6

increases expression

Menthol results in increased expression of IGFBP6 mRNA

NCBI chr 7:133,276,309...133,280,944
Ensembl chr 7:133,276,234...133,280,966

G

inhibitor of nuclear factor kappa B kinase regulatory subunit gamma

decreases expression

Menthol results in decreased expression of IKBKG mRNA

NCBI chr X:152,216,485...152,241,476
Ensembl chr X:152,216,596...152,239,499

G

interleukin 16

decreases expression

Menthol results in decreased expression of IL16 mRNA

NCBI chr 1:137,617,702...137,718,022
Ensembl chr 1:137,617,944...137,718,130

G

interleukin 1 beta

multiple interactions

Menthol inhibits the reaction [[Alendronate co-treated with Lipopolysaccharides] results in increased expression of IL1B protein]
Menthol inhibits the reaction [[MVK gene mutant form results in increased susceptibility to Lipopolysaccharides] which results in increased expression of IL1B protein]

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 2

increases expression

Menthol results in increased expression of IL2 mRNA

NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566

G

interleukin 24

decreases expression

Menthol results in decreased expression of IL24 mRNA

NCBI chr13:42,353,089...42,358,487
Ensembl chr13:42,353,090...42,358,487

G

interleukin 3

decreases expression

Menthol results in decreased expression of IL3 mRNA

NCBI chr10:38,405,716...38,408,066
Ensembl chr10:38,405,716...38,408,066

G

interleukin 6

increases secretion

Menthol results in increased secretion of IL6 protein

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

inhibitor of growth family, member 1

increases expression

Menthol results in increased expression of ING1 mRNA

NCBI chr16:77,937,276...77,945,320
Ensembl chr16:77,937,279...77,946,264

G

interferon regulatory factor 1

decreases expression

Menthol results in decreased expression of IRF1 mRNA

NCBI chr10:37,917,155...37,924,166
Ensembl chr10:37,916,670...37,924,166

G

Jun proto-oncogene, AP-1 transcription factor subunit

increases expression

Menthol results in increased expression of JUN mRNA

NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656

G

JunB proto-oncogene, AP-1 transcription factor subunit

decreases expression

Menthol results in decreased expression of JUNB mRNA

NCBI chr19:23,176,265...23,178,049
Ensembl chr19:23,176,294...23,178,035

G

JunD proto-oncogene, AP-1 transcription factor subunit

increases expression

Menthol results in increased expression of JUND mRNA

NCBI chr16:18,734,121...18,735,799
Ensembl chr16:18,734,122...18,735,799

G

lysine demethylase 5A

decreases expression

Menthol results in decreased expression of KDM5A mRNA

NCBI chr 4:153,565,909...153,643,912
Ensembl chr 4:153,565,846...153,642,422

G

kinase insert domain receptor

increases expression

Menthol results in increased expression of KDR mRNA

NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018

G

kinesin family member 20A

increases expression

Menthol results in increased expression of KIF20A mRNA

NCBI chr18:26,230,294...26,238,780
Ensembl chr18:26,230,230...26,238,780

G

KIT ligand

multiple interactions

[Tobacco Smoke Pollution co-treated with Menthol] results in increased expression of and results in increased secretion of KITLG protein

NCBI chr 7:34,896,075...34,977,215
Ensembl chr 7:34,896,053...34,977,214

G

late endosomal/lysosomal adaptor, MAPK and MTOR activator 3

multiple interactions

[Tobacco Smoke Pollution co-treated with Menthol] results in increased expression of LAMTOR3 protein

NCBI chr 2:226,411,389...226,423,612
Ensembl chr 2:226,411,400...226,423,607

G

lipopolysaccharide-induced TNF factor

increases expression

Menthol results in increased expression of LITAF mRNA

NCBI chr10:4,656,308...4,692,981
Ensembl chr10:4,625,552...4,692,763

G

lamin A/C

increases expression

Menthol results in increased expression of LMNA mRNA

NCBI chr 2:173,939,751...173,960,423
Ensembl chr 2:173,939,751...173,960,423

G

lamin B1

increases expression

Menthol results in increased expression of LMNB1 mRNA

NCBI chr18:50,175,861...50,215,210
Ensembl chr18:50,175,874...50,214,502

G

lymphotoxin beta receptor

increases expression

Menthol results in increased expression of LTBR mRNA

NCBI chr 4:158,108,884...158,115,339
Ensembl chr 4:158,108,886...158,121,539

G

MAP-kinase activating death domain

increases expression

Menthol results in increased expression of MADD mRNA

NCBI chr 3:77,114,330...77,157,865
Ensembl chr 3:77,114,314...77,157,701

G

mitogen activated protein kinase kinase 1

decreases expression

Menthol results in decreased expression of MAP2K1 mRNA

NCBI chr 8:64,683,449...64,754,900
Ensembl chr 8:64,683,449...64,755,147

G

mitogen activated protein kinase kinase 4

increases expression

Menthol results in increased expression of MAP2K4 mRNA

NCBI chr10:50,343,227...50,447,956
Ensembl chr10:50,344,915...50,447,993

G

mitogen-activated protein kinase kinase 6

decreases expression

Menthol results in decreased expression of MAP2K6 mRNA

NCBI chr10:95,373,304...95,490,406
Ensembl chr10:95,373,204...95,488,293

G

mitogen activated protein kinase kinase 7

decreases expression

Menthol results in decreased expression of MAP2K7 mRNA

NCBI chr12:2,591,312...2,600,534
Ensembl chr12:2,591,219...2,604,222

G

mitogen-activated protein kinase kinase kinase 1

increases expression

Menthol results in increased expression of MAP3K1 mRNA

NCBI chr 2:43,348,572...43,414,706
Ensembl chr 2:43,350,098...43,414,463

G

mitogen-activated protein kinase kinase kinase 14

increases expression

Menthol results in increased expression of MAP3K14 mRNA

NCBI chr10:88,165,349...88,215,558
Ensembl chr10:88,165,351...88,215,523

G

mitogen activated protein kinase kinase kinase 3

decreases expression

Menthol results in decreased expression of MAP3K3 mRNA

NCBI chr10:91,020,174...91,088,852
Ensembl chr10:91,020,174...91,088,848

G

mitogen activated protein kinase 10

decreases expression

Menthol results in decreased expression of MAPK10 mRNA

NCBI chr14:6,497,662...6,790,109
Ensembl chr14:6,497,707...6,786,201

G

mitogen-activated protein kinase 8

increases phosphorylation

Menthol results in increased phosphorylation of MAPK8 protein

NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981

G

MCL1 apoptosis regulator, BCL2 family member

increases expression

Menthol results in increased expression of MCL1 mRNA

NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303

G

MDM4 regulator of p53

increases expression

Menthol results in increased expression of MDM4 mRNA

NCBI chr13:44,432,596...44,516,165
Ensembl chr13:44,406,213...44,474,226

G

milk fat globule EGF and factor V/VIII domain containing

increases expression

Menthol results in increased expression of MFGE8 mRNA

NCBI chr 1:133,064,665...133,080,069
Ensembl chr 1:133,064,665...133,080,073

G

modulator of apoptosis 1

decreases expression

Menthol results in decreased expression of MOAP1 mRNA

NCBI chr 6:121,882,565...121,884,500
Ensembl chr 6:121,882,366...121,898,643

G

mitochondrial pyruvate carrier 2

multiple interactions

[Tobacco Smoke Pollution co-treated with Menthol] results in increased expression of MPC2 protein

NCBI chr13:77,728,176...77,747,664
Ensembl chr13:77,728,250...77,747,664

G

N-methylpurine-DNA glycosylase

decreases expression

Menthol results in decreased expression of MPG mRNA

NCBI chr10:15,396,246...15,402,528
Ensembl chr10:15,395,782...15,402,520

G

mitochondrially encoded cytochrome c oxidase II

decreases expression

Menthol results in decreased expression of COX2 protein

NCBI chr MT:7,006...7,689
NCBI chr MT:7,006...7,689
NCBI chr MT:7,006...7,689
NCBI chr MT:7,006...7,689
NCBI chr MT:7,006...7,689
NCBI chr MT:7,006...7,689
Ensembl chr MT:7,006...7,689

G

mevalonate kinase

multiple interactions

Menthol inhibits the reaction [[MVK gene mutant form results in increased susceptibility to Lipopolysaccharides] which results in increased expression of IL1B protein]; Menthol inhibits the reaction [MVK gene mutant form results in increased susceptibility to Lipopolysaccharides]

NCBI chr12:42,141,391...42,158,893
Ensembl chr12:42,141,384...42,158,882

G

MYB proto-oncogene, transcription factor

decreases expression

Menthol results in decreased expression of MYB mRNA

NCBI chr 1:15,939,771...15,973,367
Ensembl chr 1:15,939,761...15,973,057

G

MYCN proto-oncogene, bHLH transcription factor

decreases expression

Menthol results in decreased expression of MYCN mRNA

NCBI chr 6:35,717,764...35,723,590
Ensembl chr 6:35,717,764...35,723,590

G

myosin XVIIIa

increases expression

Menthol results in increased expression of MYO18A mRNA

NCBI chr10:62,654,218...62,755,465
Ensembl chr10:62,654,281...62,755,468

G

NLR family, apoptosis inhibitory protein 6

increases expression

Menthol results in increased expression of NAIP mRNA

NCBI chr 2:31,507,423...31,559,098
Ensembl chr 2:31,507,424...31,570,542

G

NADH:ubiquinone oxidoreductase subunit A12

increases expression

Menthol results in increased expression of NDUFA12 mRNA

NCBI chr 7:28,771,330...28,798,316
Ensembl chr 7:28,771,330...28,798,315

G

NADH:ubiquinone oxidoreductase subunit B8

decreases expression

Menthol results in decreased expression of NDUFB8 protein

NCBI chr 1:243,408,656...243,413,715
Ensembl chr 1:243,408,619...243,413,817

G

nuclear factor of activated T-cells 1

increases expression

Menthol results in increased expression of NFATC1 mRNA

NCBI chr18:74,046,422...74,156,041
Ensembl chr18:74,046,904...74,156,028

G

nuclear factor of activated T-cells 2

increases expression

Menthol results in increased expression of NFATC2 mRNA

NCBI chr 3:157,195,970...157,328,640
Ensembl chr 3:157,198,872...157,328,325

G

nuclear factor kappa B subunit 1

decreases expression

Menthol results in decreased expression of NFKB1 mRNA

NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404

G

nerve growth factor receptor

increases expression

Menthol results in increased expression of NGFR mRNA

NCBI chr10:80,515,287...80,533,518
Ensembl chr10:80,515,299...80,533,518

G

NLR family, CARD domain containing 4

decreases expression

Menthol results in decreased expression of NLRC4 mRNA

NCBI chr 6:20,991,785...21,018,254
Ensembl chr 6:20,995,266...21,018,248

G

NLR family, pyrin domain containing 1A

increases expression

Menthol results in increased expression of NLRP1 mRNA

NCBI chr10:55,778,560...55,833,639
Ensembl chr10:55,778,560...55,825,180

G

NME/NM23 nucleoside diphosphate kinase 3

decreases expression

Menthol results in decreased expression of NME3 mRNA

NCBI chr10:13,917,309...13,918,415
Ensembl chr10:13,917,403...13,918,359

G

NME/NM23 family member 5

decreases expression

Menthol results in decreased expression of NME5 mRNA

NCBI chr18:26,163,558...26,180,742
Ensembl chr18:26,163,555...26,180,794

G

NME/NM23 nucleoside diphosphate kinase 6

decreases expression

Menthol results in decreased expression of NME6 mRNA

NCBI chr 8:109,832,085...109,839,301
Ensembl chr 8:109,832,589...109,839,301

G

nucleotide-binding oligomerization domain containing 1

decreases expression

Menthol results in decreased expression of NOD1 mRNA

NCBI chr 4:84,060,871...84,111,668
Ensembl chr 4:84,060,880...84,111,404

G

nucleotide-binding oligomerization domain containing 2

increases expression

Menthol results in increased expression of NOD2 mRNA

NCBI chr19:18,382,369...18,422,817
Ensembl chr19:18,382,439...18,417,177

G

nucleolar protein 3

increases expression

Menthol results in increased expression of NOL3 mRNA

NCBI chr19:33,154,061...33,158,250
Ensembl chr19:33,154,062...33,158,250

G

nitric oxide synthase 1

increases expression

Menthol results in increased expression of NOS1 mRNA

NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945

G

nuclear receptor subfamily 1, group I, member 2

affects localization

Menthol affects the localization of NR1I2 protein

NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658

G

nuclear receptor subfamily 1, group I, member 3

affects localization

Menthol affects the localization of NR1I3 protein

NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906

G

neuropilin 1

increases expression

Menthol results in increased expression of NRP1 mRNA

NCBI chr19:56,359,455...56,514,628
Ensembl chr19:56,359,455...56,513,633

G

neuropilin 2

decreases expression

Menthol results in decreased expression of NRP2 mRNA

NCBI chr 9:64,122,815...64,238,007
Ensembl chr 9:64,123,132...64,237,958

G

neutral sphingomyelinase activation associated factor

increases expression

Menthol results in increased expression of NSMAF mRNA

NCBI chr 5:19,517,795...19,578,773
Ensembl chr 5:19,518,348...19,577,627

G

nuclear mitotic apparatus protein 1

increases expression

Menthol results in increased expression of NUMA1 mRNA

NCBI chr 1:156,297,907...156,372,855
Ensembl chr 1:156,326,259...156,372,855

G

nucleoporin 62

decreases expression

Menthol results in decreased expression of NUP62 mRNA

NCBI chr 1:95,298,995...95,314,902
Ensembl chr 1:95,295,526...95,315,174

G

p21 (RAC1) activated kinase 2

increases expression

Menthol results in increased expression of PAK2 mRNA

NCBI chr11:68,707,940...68,768,816
Ensembl chr11:68,707,969...68,768,816

G

Parkinsonism associated deglycase

decreases expression

Menthol results in decreased expression of PARK7 protein

NCBI chr 5:161,353,718...161,376,993
Ensembl chr 5:161,353,719...161,376,970

G

poly (ADP-ribose) polymerase family, member 8

multiple interactions

[Tobacco Smoke Pollution co-treated with Menthol] results in increased expression of PARP8 protein

NCBI chr 2:48,679,405...48,848,700
Ensembl chr 2:48,679,436...48,849,253

G

pro-apoptotic WT1 regulator

increases expression

Menthol results in increased expression of PAWR mRNA

NCBI chr 7:43,645,028...43,725,033
Ensembl chr 7:43,645,084...43,725,028

G

programmed cell death 2

decreases expression

Menthol results in decreased expression of PDCD2 mRNA

NCBI chr 1:56,484,947...56,490,437
Ensembl chr 1:56,463,931...56,490,437

G

programmed cell death 5

decreases expression

Menthol results in decreased expression of PDCD5 mRNA

NCBI chr 1:88,305,869...88,311,200
Ensembl chr 1:88,305,869...88,311,200

G

programmed cell death 6

decreases expression

Menthol results in decreased expression of PDCD6 mRNA

NCBI chr 1:28,966,518...28,982,188
Ensembl chr 1:28,966,518...28,982,189

G

phosphodiesterase 1B

decreases expression

Menthol results in decreased expression of PDE1B mRNA

NCBI chr 7:134,627,378...134,654,581
Ensembl chr 7:134,627,322...134,654,580

G

protein disulfide isomerase family A, member 6

increases expression

Menthol results in increased expression of PDIA6 protein

NCBI chr 6:40,062,980...40,080,223
Ensembl chr 6:40,062,926...40,080,613

G

penta-EF hand domain containing 1

increases expression

Menthol results in increased expression of PEF1 mRNA

NCBI chr 5:142,451,791...142,475,061
Ensembl chr 5:142,451,778...142,475,067

G

pleckstrin homology and RhoGEF domain containing G5

increases expression

Menthol results in increased expression of PLEKHG5 mRNA

NCBI chr 5:162,577,999...162,621,518
Ensembl chr 5:162,578,071...162,621,513

G

phospholipid scramblase 1

decreases expression

Menthol results in decreased expression of PLSCR1 mRNA

NCBI chr 8:92,784,279...92,804,698
Ensembl chr 8:92,784,356...92,804,692

G

PML nuclear body scaffold

decreases expression

Menthol results in decreased expression of PML mRNA

NCBI chr 8:58,627,347...58,661,927
Ensembl chr 8:58,628,837...58,658,971

G

protein phosphatase 1, regulatory subunit 15A

increases expression

Menthol results in increased expression of PPP1R15A mRNA

NCBI chr 1:96,000,053...96,003,128
Ensembl chr 1:96,000,058...96,003,171

G

polyglutamine binding protein 1

increases expression

Menthol results in increased expression of PQBP1 mRNA

NCBI chr X:14,603,516...14,608,091
Ensembl chr X:14,603,539...14,608,087

G

peroxiredoxin 1

increases expression

Menthol results in increased expression of PRDX1 protein

NCBI chr 5:130,147,258...130,162,856
Ensembl chr 5:130,147,204...130,162,856

G

peroxiredoxin 5

decreases expression

Menthol results in decreased expression of PRDX5 mRNA

NCBI chr 1:204,099,826...204,103,589
Ensembl chr 1:204,099,826...204,114,268

G

perforin 1

decreases expression

Menthol results in decreased expression of PRF1 mRNA

NCBI chr20:29,246,202...29,251,712
Ensembl chr20:29,246,202...29,251,701

G

proline dehydrogenase

increases expression

Menthol results in increased expression of PRODH mRNA

NCBI chr11:82,910,043...82,927,305
Ensembl chr11:82,910,137...82,927,305

G

presenilin 1

decreases expression

Menthol results in decreased expression of PSEN1 mRNA

NCBI chr 6:103,323,052...103,375,088
Ensembl chr 6:103,323,120...103,371,650

G

proteasome 20S subunit alpha 3

increases expression

Menthol results in increased expression of PSMA3 protein

NCBI chr 6:89,483,741...89,503,775
Ensembl chr 6:89,483,727...89,504,965

G

proteasome 20S subunit alpha 5

increases expression

Menthol results in increased expression of PSMA5 protein

NCBI chr 2:195,896,369...195,919,733
Ensembl chr 2:195,896,365...195,919,731

G

prostaglandin E synthase

decreases expression

Menthol results in decreased expression of PTGES mRNA

NCBI chr 3:14,177,892...14,189,236

G

protein tyrosine kinase 2

decreases expression

Menthol results in decreased expression of PTK2 mRNA

NCBI chr 7:105,126,725...105,331,848
Ensembl chr 7:105,126,728...105,331,783

G

protein tyrosine phosphatase, non-receptor type 13

increases expression

Menthol results in increased expression of PTPN13 mRNA

NCBI chr14:6,108,202...6,282,619
Ensembl chr14:6,108,211...6,282,563

G

PYD and CARD domain containing

decreases expression

Menthol results in decreased expression of PYCARD mRNA

NCBI chr 1:182,601,657...182,603,013
Ensembl chr 1:182,601,174...182,602,955

G

RAD23 homolog B, nucleotide excision repair protein

decreases expression

Menthol results in decreased expression of RAD23B mRNA

NCBI chr 5:70,090,232...70,128,340
Ensembl chr 5:70,090,232...70,128,319

G

Raf-1 proto-oncogene, serine/threonine kinase

decreases expression

Menthol results in decreased expression of RAF1 mRNA

NCBI chr 4:148,679,534...148,740,265
Ensembl chr 4:148,679,530...148,740,317

G

RAP1A, member of RAS oncogene family

multiple interactions
increases expression

Mevalonic Acid affects the reaction [Menthol analog results in increased expression of RAP1A protein]; Mevalonic Acid affects the reaction [Menthol results in increased expression of RAP1A protein]

NCBI chr 2:193,208,631...193,286,513
Ensembl chr 2:193,208,635...193,286,501

G

RB transcriptional corepressor 1

increases expression

Menthol results in increased expression of RB1 mRNA

NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302

G

RB binding protein 5, histone lysine methyltransferase complex subunit

decreases expression

Menthol results in decreased expression of RBBP5 mRNA

NCBI chr13:43,912,254...43,939,107
Ensembl chr13:43,912,254...43,939,107

G

RB binding protein 6, ubiquitin ligase

increases expression

Menthol results in increased expression of RBBP6 mRNA

NCBI chr 1:177,503,988...177,537,397
Ensembl chr 1:177,503,313...177,535,678

G

RB transcriptional corepressor like 2

decreases expression

Menthol results in decreased expression of RBL2 mRNA

NCBI chr19:15,876,852...15,923,632
Ensembl chr19:15,876,853...15,923,572

G

RELA proto-oncogene, NF-kB subunit

increases phosphorylation

Menthol results in increased phosphorylation of RELA protein

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

ras homolog family member A

increases expression
multiple interactions

Menthol analog results in increased expression of RHOA protein
Mevalonic Acid affects the reaction [Menthol analog results in increased expression of RHOA protein]

NCBI chr 8:108,991,926...109,025,746
Ensembl chr 8:108,991,954...109,025,746

G

ras homolog family member B

increases expression
multiple interactions

Menthol analog results in increased expression of RHOB protein; Menthol results in increased expression of RHOB protein
Mevalonic Acid affects the reaction [Menthol analog results in increased expression of RHOB protein]; Mevalonic Acid affects the reaction [Menthol results in increased expression of RHOB protein]

NCBI chr 6:31,363,752...31,365,926
Ensembl chr 6:31,363,548...31,366,108

G

receptor interacting serine/threonine kinase 1

increases expression

Menthol results in increased expression of RIPK1 mRNA

NCBI chr17:30,839,639...30,871,824
Ensembl chr17:30,839,650...30,871,824

G

receptor-interacting serine-threonine kinase 2

increases expression

Menthol results in increased expression of RIPK2 mRNA

NCBI chr 5:29,630,806...29,662,804
Ensembl chr 5:29,631,570...29,662,657

G

receptor-interacting serine-threonine kinase 3

increases expression

Menthol results in increased expression of RIPK3 mRNA

NCBI chr15:29,283,153...29,292,107
Ensembl chr15:29,283,145...29,292,121

G

ribosomal protein L31

decreases expression

Menthol results in decreased expression of RPL31 mRNA

NCBI chr 9:41,647,397...41,651,441
Ensembl chr 9:41,647,426...41,662,129

G

ribosomal protein L7

increases expression

Menthol results in increased expression of RPL7 mRNA

NCBI chr 5:3,217,184...3,220,192

G

ribosomal protein S20

increases expression

Menthol results in increased expression of RPS20 mRNA

NCBI chr 5:16,819,095...16,820,476
Ensembl chr 5:16,819,304...16,820,475
Ensembl chr 9:16,819,304...16,820,475
Ensembl chr 3:16,819,304...16,820,475

G

ribosomal protein S3a

increases expression

Menthol results in increased expression of RPS3A mRNA

NCBI chr 2:171,524,685...171,529,054
Ensembl chr 2:171,524,500...171,529,055

G

ribosomal protein S9

decreases expression

Menthol results in decreased expression of RPS9 mRNA

NCBI chr 1:65,511,723...65,515,076
Ensembl chr 1:65,511,723...65,515,123

G

succinate dehydrogenase complex iron sulfur subunit B

decreases expression

Menthol results in decreased expression of SDHB protein

NCBI chr 5:153,264,906...153,285,570
Ensembl chr 5:153,264,899...153,314,293

G

serpin family B member 9

increases expression

Menthol results in increased expression of SERPINB9 mRNA

NCBI chr17:31,420,118...31,443,237
Ensembl chr17:31,420,125...31,443,230

G

secreted frizzled-related protein 1

increases expression

Menthol results in increased expression of SFRP1 mRNA

NCBI chr16:68,575,763...68,614,180
Ensembl chr16:68,575,763...68,614,286

G

siah E3 ubiquitin protein ligase 1

decreases expression

Menthol results in decreased expression of SIAH1 mRNA

NCBI chr19:20,378,908...20,402,512
Ensembl chr19:20,378,439...20,403,808

G

solute carrier family 25 member 4

decreases expression

Menthol results in decreased expression of SLC25A4 mRNA

NCBI chr16:46,072,935...46,076,730
Ensembl chr16:46,072,939...46,076,733

G

superoxide dismutase 1

increases expression

Menthol results in increased expression of SOD1 mRNA

NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249

G

superoxide dismutase 2

decreases expression
multiple interactions
increases expression

Menthol results in decreased expression of SOD2 mRNA
TRPM8 protein affects the reaction [Menthol results in increased expression of SOD2 protein]

PMID:26760959 PMID:32950532

NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189

G

spectrin, alpha, non-erythrocytic 1

decreases expression

Menthol results in decreased expression of SPTAN1 mRNA

NCBI chr 3:13,241,164...13,306,047
Ensembl chr 3:13,241,217...13,306,046

G

spectrin, beta, non-erythrocytic 1

increases expression

Menthol results in increased expression of SPTBN1 mRNA

NCBI chr14:103,841,713...104,016,900
Ensembl chr14:103,842,684...104,008,507

G

sterol regulatory element binding transcription factor 1

decreases expression

Menthol results in decreased expression of SREBF1 mRNA

NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650

G

sterol regulatory element binding transcription factor 2

decreases expression

Menthol results in decreased expression of SREBF2 mRNA

NCBI chr 7:113,663,202...113,720,850
Ensembl chr 7:113,663,202...113,720,848

G

signal recognition particle 72

decreases expression

Menthol results in decreased expression of SRP72 mRNA

NCBI chr14:31,168,175...31,195,717
Ensembl chr14:31,168,293...31,195,729

G

serine/threonine kinase 17b

decreases expression

Menthol results in decreased expression of STK17B mRNA

NCBI chr 9:55,307,485...55,338,085
Ensembl chr 9:55,307,668...55,338,031

G

syntaxin 11

decreases expression

Menthol results in decreased expression of STX11 mRNA

NCBI chr 1:7,293,427...7,320,060
Ensembl chr 1:7,289,976...7,320,164

G

TRAF family member-associated NFKB activator

decreases expression

Menthol results in decreased expression of TANK mRNA

NCBI chr 3:46,114,230...46,190,270
Ensembl chr 3:46,114,274...46,190,264

G

tyrosyl-DNA phosphodiesterase 2

increases expression

Menthol results in increased expression of TDP2 mRNA

NCBI chr17:40,228,943...40,240,337
Ensembl chr17:40,228,947...40,240,313

G

transcription factor Dp-1

decreases expression

Menthol results in decreased expression of TFDP1 mRNA

NCBI chr16:76,162,040...76,200,871
Ensembl chr16:76,162,043...76,200,817

G

transcription factor Dp-2

decreases expression

Menthol results in decreased expression of TFDP2 mRNA

NCBI chr 8:96,760,459...96,901,466
Ensembl chr 8:96,760,504...96,896,682

G

Tia1 cytotoxic granule-associated RNA binding protein-like 1

decreases expression

Menthol results in decreased expression of TIAL1 mRNA

NCBI chr 1:183,008,358...183,045,092
Ensembl chr 1:183,009,253...183,031,637

G

TIMP metallopeptidase inhibitor 1

multiple interactions

[Tobacco Smoke Pollution co-treated with Menthol] results in increased expression of and results in increased secretion of TIMP1 protein

NCBI chr X:1,212,969...1,217,714
Ensembl chr X:1,212,972...1,217,664

G

tumor necrosis factor

decreases expression

Menthol results in decreased expression of TNF mRNA

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

TNF alpha induced protein 1

decreases expression

Menthol results in decreased expression of TNFAIP1 mRNA

NCBI chr10:63,417,774...63,432,466
Ensembl chr10:63,417,775...63,432,466

G

TNF alpha induced protein 2

increases expression

Menthol results in increased expression of TNFAIP2 mRNA

NCBI chr 6:130,476,832...130,489,914
Ensembl chr 6:130,476,889...130,489,914

G

TNF alpha induced protein 3

decreases expression

Menthol results in decreased expression of TNFAIP3 mRNA

NCBI chr 1:13,709,211...13,724,291
Ensembl chr 1:13,709,206...13,725,282

G

TNF alpha induced protein 6

decreases expression

Menthol results in decreased expression of TNFAIP6 mRNA

NCBI chr 3:36,502,250...36,521,652
Ensembl chr 3:36,502,188...36,521,649

G

TNF alpha induced protein 8

decreases expression

Menthol results in decreased expression of TNFAIP8 mRNA

NCBI chr18:43,183,854...43,299,512
Ensembl chr18:43,183,916...43,299,517

G

TNF receptor superfamily member 10b

increases expression

Menthol results in increased expression of TNFRSF10A mRNA

NCBI chr15:44,840,386...44,868,318
Ensembl chr15:44,840,386...44,867,467

G

TNF receptor superfamily member 11A

decreases expression

Menthol results in decreased expression of TNFRSF11A mRNA

NCBI chr13:21,928,370...21,986,719
Ensembl chr13:21,928,408...21,986,695

G

TNF receptor superfamily member 11B

decreases expression

Menthol results in decreased expression of TNFRSF11B mRNA

NCBI chr 7:85,566,520...85,594,526
Ensembl chr 7:85,566,520...85,594,538

G

TNF receptor superfamily member 14

increases expression

Menthol results in increased expression of TNFRSF14 mRNA

NCBI chr 5:165,486,069...165,494,421
Ensembl chr 5:165,484,262...165,493,703

G

TNF receptor superfamily member 17

increases expression

Menthol results in increased expression of TNFRSF17 mRNA

NCBI chr10:4,301,023...4,306,889
Ensembl chr10:4,301,038...4,306,788

G

TNF receptor superfamily member 1B

increases expression

Menthol results in increased expression of TNFRSF1B mRNA

NCBI chr 5:157,070,642...157,104,216
Ensembl chr 5:157,070,642...157,104,206

G

TNF receptor superfamily member 21

decreases expression

Menthol results in decreased expression of TNFRSF21 mRNA

NCBI chr 9:17,879,156...17,954,085
Ensembl chr 9:17,879,156...17,954,085

G

tumor necrosis factor receptor superfamily, member 22

decreases expression

Menthol results in decreased expression of TNFRSF10C mRNA

NCBI chr 1:198,840,452...198,860,713
Ensembl chr 1:198,840,453...198,856,309

G

TNF receptor superfamily member 25

decreases expression

Menthol results in decreased expression of TNFRSF25 mRNA

NCBI chr 5:162,621,669...162,626,341
Ensembl chr 5:162,622,075...162,626,341

G

TNF receptor superfamily member 4

decreases expression

Menthol results in decreased expression of TNFRSF4 mRNA

NCBI chr 5:166,606,909...166,609,599
Ensembl chr 5:166,606,909...166,609,599

G

TNF receptor superfamily member 8

decreases expression

Menthol results in decreased expression of TNFRSF8 mRNA

NCBI chr 5:157,123,183...157,168,421
Ensembl chr 5:157,123,185...157,168,421

G

TNF receptor superfamily member 9

increases expression

Menthol results in increased expression of TNFRSF9 mRNA

NCBI chr 5:161,381,662...161,408,003
Ensembl chr 5:161,381,662...161,408,000

G

TNF superfamily member 10

decreases expression

Menthol results in decreased expression of TNFSF10 mRNA

NCBI chr 2:110,199,835...110,227,239
Ensembl chr 2:110,207,916...110,225,135

G

TNF superfamily member 12

decreases expression

Menthol results in decreased expression of TNFSF12 mRNA

NCBI chr10:54,403,870...54,413,213
Ensembl chr10:54,403,870...54,413,213

G

TNF superfamily member 13

decreases expression

Menthol results in decreased expression of TNFSF13 mRNA

NCBI chr10:54,400,054...54,403,723
Ensembl chr10:54,400,065...54,403,042

G

TNF superfamily member 14

decreases expression

Menthol results in decreased expression of TNFSF14 mRNA

NCBI chr 9:2,068,295...2,073,128
Ensembl chr 9:2,069,104...2,073,216

G

TNF superfamily member 15

decreases expression

Menthol results in decreased expression of TNFSF15 mRNA

NCBI chr 5:77,134,885...77,156,171
Ensembl chr 5:77,139,878...77,156,228

G

TNF superfamily member 18

increases expression

Menthol results in increased expression of TNFSF18 mRNA

NCBI chr13:73,833,478...73,907,249
Ensembl chr13:73,831,252...73,843,169

G

TNF superfamily member 4

increases expression

Menthol results in increased expression of TNFSF4 mRNA

NCBI chr13:73,723,329...73,746,809
Ensembl chr13:73,723,329...73,746,788

G

TNF superfamily member 8

decreases expression

Menthol results in decreased expression of TNFSF8 mRNA

NCBI chr 5:77,250,942...77,277,364
Ensembl chr 5:77,251,373...77,277,421

G

TNF superfamily member 9

increases expression

Menthol results in increased expression of TNFSF9 mRNA

NCBI chr 9:1,944,017...1,946,351
Ensembl chr 9:1,944,017...1,946,345

G

DNA topoisomerase I

decreases activity
decreases expression

Menthol results in decreased activity of TOP1 protein
Menthol results in decreased expression of TOP1 mRNA

PMID:16158947 PMID:26760959

NCBI chr 3:149,293,469...149,376,618
Ensembl chr 3:149,293,403...149,376,623

G

DNA topoisomerase II alpha

decreases activity
increases expression

Menthol results in decreased activity of TOP2A protein
Menthol results in increased expression of TOP2A mRNA

PMID:16158947 PMID:26760959

NCBI chr10:83,945,731...83,976,874
Ensembl chr10:83,945,735...83,976,874

G

DNA topoisomerase II beta

decreases activity
increases expression

Menthol results in decreased activity of TOP2B protein
Menthol results in increased expression of TOP2B mRNA

PMID:16158947 PMID:26760959

NCBI chr15:9,051,340...9,111,721
Ensembl chr15:9,051,341...9,112,085

G

tumor protein p53

increases expression

Menthol results in increased expression of TP53 mRNA

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

G

tumor protein p53 binding protein, 2

increases expression

Menthol results in increased expression of TP53BP2 mRNA

NCBI chr13:94,088,769...94,145,436
Ensembl chr13:94,088,709...94,145,432

G

tumor protein p53 inducible protein 3

increases expression

Menthol results in increased expression of TP53I3 mRNA

NCBI chr 6:27,818,327...27,825,753

G

tumor protein p73

decreases expression

Menthol results in decreased expression of TP73 mRNA

NCBI chr 5:164,621,377...164,703,958
Ensembl chr 5:164,621,377...164,681,128

G

triosephosphate isomerase 1

increases expression

Menthol results in increased expression of TPI1 protein

NCBI chr 4:157,615,283...157,618,813
Ensembl chr 4:157,615,386...157,619,541

G

TNFRSF1A-associated via death domain

increases expression

Menthol results in increased expression of TRADD mRNA

NCBI chr19:33,136,148...33,142,714
Ensembl chr19:33,136,138...33,142,638

G

TNF receptor-associated factor 1

decreases expression

Menthol results in decreased expression of TRAF1 mRNA

NCBI chr 3:18,222,024...18,242,163
Ensembl chr 3:18,222,054...18,241,807

G

Tnf receptor-associated factor 2

decreases expression

Menthol results in decreased expression of TRAF2 mRNA

NCBI chr 3:8,341,950...8,366,609
Ensembl chr 3:8,341,951...8,366,538

G

Tnf receptor-associated factor 3

increases expression

Menthol results in increased expression of TRAF3 mRNA

NCBI chr 6:130,199,696...130,307,168
Ensembl chr 6:130,206,484...130,305,481

G

TRAF3 interacting protein 1

decreases expression

Menthol results in decreased expression of TRAF3IP1 mRNA

NCBI chr 9:92,073,622...92,110,427
Ensembl chr 9:92,073,640...92,108,977

G

Tnf receptor associated factor 4

decreases expression

Menthol results in decreased expression of TRAF4 mRNA

NCBI chr10:63,054,169...63,060,284
Ensembl chr10:63,054,181...63,060,284

G

TNF receptor-associated factor 5

decreases expression

Menthol results in decreased expression of TRAF5 mRNA

NCBI chr13:103,569,944...103,618,747
Ensembl chr13:103,572,314...103,618,709

G

TNF receptor associated factor 6

decreases expression

Menthol results in decreased expression of TRAF6 mRNA

NCBI chr 3:87,963,517...87,988,316
Ensembl chr 3:87,963,514...87,983,507

G

TRAF-interacting protein

decreases expression

Menthol results in decreased expression of TRAIP mRNA

NCBI chr 8:108,641,860...108,661,640
Ensembl chr 8:108,641,852...108,661,638

G

transient receptor potential cation channel, subfamily A, member 1

increases activity

Menthol results in increased activity of TRPA1 protein

NCBI chr 5:4,379,862...4,434,133
Ensembl chr 5:4,379,999...4,433,570

G

transient receptor potential cation channel, subfamily M, member 8

multiple interactions
decreases response to substance
increases response to substance
affects response to substance
increases activity

[Menthol analog binds to and results in increased activity of TRPM8 protein] which results in increased transport of Calcium; [Menthol results in increased activity of TRPM8 protein] which results in increased transport of Calcium; Menthol analog binds to and results in increased activity of TRPM8 protein; Menthol inhibits the reaction [Praziquantel results in increased activity of TRPM8 protein]; Menthol promotes the reaction [TRPM8 protein results in increased transport of Calcium]; Praziquantel inhibits the reaction [Menthol results in increased activity of TRPM8 protein]; TRPM8 protein affects the reaction [Menthol results in increased expression of SOD2 protein]
TRPM8 gene mutant form results in decreased susceptibility to Menthol
TRPM8 protein results in increased susceptibility to Menthol
6-(bromomethylene)tetrahydro-3-(1-naphthaleneyl)-2H-pyran-2-one inhibits the reaction [icilin inhibits the reaction [Menthol results in increased activity of TRPM8 protein]]; 6-(bromomethylene)tetrahydro-3-(1-naphthaleneyl)-2H-pyran-2-one inhibits the reaction [Menthol inhibits the reaction [Menthol results in increased activity of TRPM8 protein]]; 6-(bromomethylene)tetrahydro-3-(1-naphthaleneyl)-2H-pyran-2-one inhibits the reaction [Menthol inhibits the reaction [Phenylephrine results in increased activity of TRPM8 protein]]; Menthol binds to and results in increased activity of TRPM8 protein; Menthol inhibits the reaction [Phenylephrine results in increased activity of TRPM8 protein]; Menthol inhibits the reaction [Potassium Chloride results in increased activity of TRPM8 protein]
TRPM8 protein affects the susceptibility to Menthol
Menthol results in increased activity of TRPM8; Menthol results in increased activity of TRPM8 protein
1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Menthol results in increased activity of TRPM8]; [Menthol binds to and results in increased activity of TRPM8 protein] which affects the abundance of Calcium
Menthol analog results in increased activity of TRPM8 protein; Menthol results in increased activity of TRPM8 protein

PMID:15046718 PMID:16174775 PMID:16520735 PMID:17481392 PMID:17517434 More...

NCBI chr 9:88,897,039...88,990,167
Ensembl chr 9:88,903,880...88,988,552

G

transient receptor potential cation channel, subfamily V, member 1

increases activity

Menthol results in increased activity of TRPV1 protein

NCBI chr10:57,851,428...57,876,513
Ensembl chr10:57,851,428...57,876,513

G

translocator protein

decreases expression

Menthol results in decreased expression of TSPO mRNA

NCBI chr 7:114,720,188...114,730,450
Ensembl chr 7:114,720,188...114,730,450

G

UDP glucuronosyltransferase family 2 member B15

increases metabolic processing

UGT2B15 protein results in increased metabolism of Menthol

NCBI chr14:20,768,015...20,783,599
Ensembl chr14:20,768,015...20,783,589

G

UDP glucuronosyltransferase family 2 member B7

increases glucuronidation

UGT2B7 protein results in increased glucuronidation of Menthol

NCBI chr14:20,896,682...20,919,604
Ensembl chr14:20,896,682...20,919,604

G

voltage-dependent anion channel 1

decreases expression

Menthol results in decreased expression of VDAC1 mRNA

NCBI chr10:36,532,306...36,559,642
Ensembl chr10:36,532,244...36,559,640

G

voltage-dependent anion channel 2

increases expression

Menthol results in increased expression of VDAC2 mRNA

NCBI chr15:2,462,877...2,476,802
Ensembl chr15:2,463,056...2,476,553

G

vascular endothelial growth factor A

decreases expression

Menthol results in decreased expression of VEGF mRNA

NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641

G

vascular endothelial growth factor B

increases expression

Menthol results in increased expression of VEGFB mRNA

NCBI chr 1:204,172,297...204,178,046
Ensembl chr 1:204,172,225...204,177,944

G

vascular endothelial growth factor C

decreases expression

Menthol results in decreased expression of VEGFC mRNA

NCBI chr16:37,712,251...37,827,845
Ensembl chr16:37,712,262...37,827,848

G

vascular endothelial growth factor D

increases expression

Menthol results in increased expression of VEGFD mRNA

NCBI chr X:30,073,122...30,108,413
Ensembl chr X:30,074,163...30,108,295

G

von Willebrand factor

multiple interactions

[Tobacco Smoke Pollution co-treated with Menthol] results in increased expression of and results in increased secretion of VWF protein

NCBI chr 4:158,360,152...158,491,539
Ensembl chr 4:158,360,152...158,491,539

G

X-linked inhibitor of apoptosis

increases expression

Menthol results in increased expression of XIAP mRNA

NCBI chr X:120,890,537...120,938,413
Ensembl chr X:120,897,907...120,934,700

G

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon

affects expression

Menthol affects the expression of YWHAE protein

NCBI chr10:60,584,665...60,622,352
Ensembl chr10:60,584,652...60,671,589

G

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta

decreases expression

Menthol results in decreased expression of YWHAZ protein

NCBI chr 7:67,941,353...67,963,651
Ensembl chr 7:67,940,017...67,963,668

G

zinc finger protein 36, C3H type-like 1

increases expression

Menthol results in increased expression of ZFP36L1 mRNA

NCBI chr 6:98,930,705...98,935,748
Ensembl chr 6:98,930,718...98,935,748

G

zinc finger protein 709

decreases expression

Menthol results in decreased expression of ZNF443 mRNA

NCBI chr16:17,907,599...17,920,047
Ensembl chr16:17,909,641...17,919,700

G

zinc finger RANBP2-type containing 1

decreases expression

Menthol results in decreased expression of ZRANB1 mRNA

NCBI chr 1:187,725,354...187,780,129
Ensembl chr 1:187,724,320...187,779,655

perillyl alcohol

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

BCL2-antagonist/killer 1

increases expression

perillyl alcohol results in increased expression of BAK1 protein

NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264

G

BCL2 associated X, apoptosis regulator

multiple interactions

perillyl alcohol inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased expression of BAX protein]

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

BCL2, apoptosis regulator

multiple interactions

perillyl alcohol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of BCL2 protein]

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

catalase

multiple interactions

perillyl alcohol inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased activity of CAT protein]
perillyl alcohol inhibits the reaction [Ethanol results in decreased activity of CAT protein]

PMID:19161993 PMID:20923693

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

cyclin A2

decreases expression

perillyl alcohol results in decreased expression of CCNA2 protein

NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577

G

cyclin B1

decreases expression

perillyl alcohol results in decreased expression of CCNB1 protein

NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172

G

cyclin dependent kinase 2

decreases expression
multiple interactions

perillyl alcohol results in decreased expression of CDK2 protein
perillyl alcohol promotes the reaction [CDKN1A protein binds to and results in decreased activity of CDK2 protein]; perillyl alcohol promotes the reaction [CDKN1B protein binds to and results in decreased activity of CDK2 protein]

NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403

G

cyclin-dependent kinase inhibitor 1A

increases response to substance
multiple interactions
increases expression

CDKN1A protein results in increased susceptibility to perillyl alcohol
perillyl alcohol promotes the reaction [CDKN1A protein binds to and results in decreased activity of CDK2 protein]
perillyl alcohol results in increased expression of CDKN1A protein

NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585

G

cyclin-dependent kinase inhibitor 1B

increases response to substance
increases expression
multiple interactions

CDKN1B protein results in increased susceptibility to perillyl alcohol
perillyl alcohol results in increased expression of CDKN1B protein
perillyl alcohol promotes the reaction [CDKN1B protein binds to and results in decreased activity of CDK2 protein]

NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982

G

F-box protein 32

increases expression

perillyl alcohol results in increased expression of FBXO32 mRNA; perillyl alcohol results in increased expression of FBXO32 protein

NCBI chr 7:89,731,428...89,764,997
Ensembl chr 7:89,730,232...89,765,436

G

farnesyltransferase, CAAX box, subunit alpha

multiple interactions

[Vitamin A co-treated with perillyl alcohol] results in decreased expression of FNTA protein

NCBI chr16:66,065,131...66,083,460
Ensembl chr16:66,065,132...66,083,460

G

farnesyltransferase, CAAX box, subunit beta

multiple interactions
increases expression
decreases expression

[perillyl alcohol co-treated with Vitamin A] results in decreased expression of FNTB mRNA
perillyl alcohol results in increased expression of FNTB protein
perillyl alcohol results in decreased expression of FNTB mRNA

NCBI chr 6:95,536,540...95,619,587
Ensembl chr 6:95,470,683...95,619,586

G

glutathione-disulfide reductase

multiple interactions

perillyl alcohol inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased expression of GSR protein]
perillyl alcohol inhibits the reaction [Ethanol results in decreased activity of GSR protein]

PMID:19161993 PMID:20923693

NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661

G

hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)

multiple interactions

perillyl alcohol inhibits the reaction [Ethanol results in decreased activity of H6PD protein]

NCBI chr 5:160,434,499...160,470,203
Ensembl chr 5:160,438,697...160,470,171

G

involucrin

decreases expression

perillyl alcohol results in decreased expression of IVL protein

NCBI chr 2:178,146,694...178,160,807
Ensembl chr 2:178,147,061...178,149,100

G

mitogen activated protein kinase 1

multiple interactions

perillyl alcohol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK1 protein]

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

multiple interactions

perillyl alcohol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK3 protein]

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

ornithine decarboxylase 1

multiple interactions

perillyl alcohol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of ODC1 protein]

NCBI chr 6:40,329,831...40,336,444
Ensembl chr 6:40,329,964...40,336,440

G

Raf-1 proto-oncogene, serine/threonine kinase

multiple interactions

perillyl alcohol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of RAF1 protein]

NCBI chr 4:148,679,534...148,740,265
Ensembl chr 4:148,679,530...148,740,317

G

RAP1A, member of RAS oncogene family

multiple interactions
increases expression

Mevalonic Acid affects the reaction [perillyl alcohol results in increased expression of RAP1A protein]

NCBI chr 2:193,208,631...193,286,513
Ensembl chr 2:193,208,635...193,286,501

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

perillyl alcohol inhibits the reaction [Ethanol results in increased activity of RELA protein]

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

ras homolog family member A

multiple interactions
increases expression

Mevalonic Acid affects the reaction [perillyl alcohol results in increased expression of RHOA protein]
[perillyl alcohol co-treated with Vitamin A] results in increased expression of RHOA mRNA

PMID:12671036 PMID:15959631

NCBI chr 8:108,991,926...109,025,746
Ensembl chr 8:108,991,954...109,025,746

G

ras homolog family member B

multiple interactions
increases expression

Mevalonic Acid affects the reaction [perillyl alcohol results in increased expression of RHOB protein]
perillyl alcohol results in increased expression of RHOB mRNA; perillyl alcohol results in increased expression of RHOB protein
[perillyl alcohol co-treated with Vitamin A] affects the expression of RHOB mRNA; [perillyl alcohol co-treated with Vitamin A] affects the expression of RHOB protein

PMID:12671036 PMID:15959631

NCBI chr 6:31,363,752...31,365,926
Ensembl chr 6:31,363,548...31,366,108

G

tumor necrosis factor

multiple interactions

perillyl alcohol inhibits the reaction [Ethanol results in increased expression of TNF protein]

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

tea tree oil

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

androgen receptor

multiple interactions

Tea Tree Oil inhibits the reaction [Testosterone results in increased activity of AR protein]

NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925

G

cathepsin D

multiple interactions
increases expression

Fulvestrant inhibits the reaction [Tea Tree Oil results in increased expression of CTSD mRNA]

NCBI chr 1:197,527,467...197,539,343
Ensembl chr 1:197,527,467...197,539,488

G

cytochrome P450, family 4, subfamily f, polypeptide 6

multiple interactions

Tea Tree Oil inhibits the reaction [Testosterone results in increased expression of CYP4F8 mRNA]

NCBI chr 7:12,030,276...12,058,020
Ensembl chr 7:12,030,301...12,057,782

G

estrogen receptor 1

increases activity

Tea Tree Oil results in increased activity of ESR1 protein

NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002

G

growth regulating estrogen receptor binding 1

multiple interactions
increases expression

Fulvestrant inhibits the reaction [Tea Tree Oil results in increased expression of GREB1 mRNA]

NCBI chr 6:39,440,522...39,562,364
Ensembl chr 6:39,440,504...39,581,633

G

progesterone receptor

increases expression
multiple interactions

Tea Tree Oil results in increased expression of PGR mRNA
Fulvestrant inhibits the reaction [Tea Tree Oil results in increased expression of PGR mRNA]

NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:6,072,673...6,131,344

G

SEC14-like lipid binding 2

multiple interactions

Tea Tree Oil inhibits the reaction [Testosterone results in increased expression of SEC14L2 mRNA]

NCBI chr14:78,973,805...78,998,480
Ensembl chr14:78,973,808...78,993,788

G

UDP glucuronosyltransferase 2 family, polypeptide B34 like 1

multiple interactions

Tea Tree Oil inhibits the reaction [Testosterone results in increased expression of UGT2B28 mRNA]

NCBI chr14:21,146,140...21,167,706
Ensembl chr14:21,145,827...21,167,704

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	19932
chemical entity	19930
atom	19930
nonmetal atom	19859
carbon atom	19812
organic molecular entity	19812
isoprenoid	14071
terpenoid	13771
monoterpenoid	2045
p-menthane monoterpenoid	489
(+)-(6S)-hydroxymenthol	0
(+)-7-Hydroxymenthol	0
(+)-8-Acetoxycarvone	0
(+)-sabinone	0
(+)-trans-Piperitenol	0
(+)-trans-Pulegol	0
(+/-)-Menthyl acetate	0
(-)-Menthyl acetate	0
(-)-Pulegone	0
(1R,2R,4R,8R)-p-Menthane-2,8,9-triol	0
(1R,2R,4R,8S)-(-)-p-menthane-2,8,9-triol	0
(1R,2R,4S)-p-Menthane-1,2,8-triol	0
(1R,2S,3S,4R)-p-Menthane-2,3-diol	0
(1R,4R)-p-Mentha-2,8-dien-1-ol	0
(1R,4S)-1-hydroperoxy-p-menth-2-en-8-ol acetate	0
(1S,2S,4R,8R)-p-Menthane-1,2,8,9-tetrol	0
(1S,2S,4R,8R)-p-Menthane-1,2,9-triol	0
(1S,2S,4S)-p-menthane-1,2,4-triol	0
(1S,3R,4R)-p-Menthane-1,3-diol	0
(1S,4R)-p-Mentha-2,8-dien-1-ol	0
(1S,4S)-menthone-8-thioacetate	0
(1alpha,2alpha,4betaH,6alpha,8R)-p-Menthane-2,6,8,9-tetrol	0
(2S,4R)-p-Mentha-1(7),5-dien-2-ol	0
(2S,4R)-p-Mentha-1(7),8-dien-2-ol	0
(4R)-4-(1-methylethenyl)-1-cyclohexenecarboxylic acid	0
(4S,8R)-8,9-Dihydroxy-p-menth-1(6)-en-2-one	0
(7R)-1-hydroxy-3-p-menthen-9-oic acid	0
(7S)-1-hydroxy-3-p-menthen-9-oic acid	0
(E)-2-(Hydroxymethyl)-3-[(1S,2R,5S)-5-(hydroxymethyl)-2-propan-2-ylcyclohexyl]prop-2-enoic acid	0
(R)-2-Nitro-p-mentha-1,5-diene	0
(R)-p-Mentha-1,8-dien-10-ol	0
(S)-Oleuropeic acid	0
(S)-menthone 8-thioacetate	0
1(7),8(10)-p-Menthadien-9-ol	0
1,1,2-Trimethyl-3,5-bis(1-methylethenyl)cyclohexane	0
1,2-Dimethyl-3,5-bis(1-methylethenyl)cyclohexane	0
1-Ethoxy-p-menth-2-ene	0
1-Hydroxypropan-2-yl 2-isopropyl-5-methylcyclohexyl carbonate	0
1-Isopropyl-4-methylcyclohex-3-en-1-yl acetate	0
10alpha-4,5-Seco-11-eudesmene-4,5-dione	0
12-nor-11-acetoxybisabolen-3,6,7-triol	0
14-acetylgliocladic acid	0
2-(2-hydroxy-4-methylcyclohex-3-enyl)propanoic acid	0
2-(4-Methylcyclohex-3-en-1-yl)propane-2-thiol	0
2-(Hydroxymethyl)-3-[3-(hydroxymethyl)-6-propan-2-ylcyclohex-2-en-1-yl]prop-2-enoic acid	0
2-Hydroxy-p-mentha-1,8-dien-6-one	0
2-Hydroxypropyl 2-isopropyl-5-methylcyclohexyl carbonate	0
2-Menthene	0
2-p-Menthen-1-ol	0
3-(L-Menthoxy)-2-methylpropane-1,2-diol	0
3-Hydroxy-p-mentha-1,8-dien-7-al	0
3-[[5-Methyl-2-(1-methylethyl)cyclohexyl]oxy]-1,2-propanediol	0
3-acetylgliocladic acid	0
4-(2-Methoxypropan-2-yl)-1-methylcyclohex-1-ene	0
4-Isopropyl-3-cyclohexene-1-carboxylic acid	0
4-Methyl-2-methylene-1-(1methylethylidene)-cyclohexane	0
4-hydroxy-5-isopropenyl-2-methyl-2-cyclohexen-1-one	0
4-isopropylbenzyl alcohol	0
5,5-Diisopropyl-2,2'-dimethylbiphenyl-3,3',4,4'-tetrone	0
5-Isopropyl-2-(2-methylpropyl)-2-cyclohexen-1-one	0
5-hydroxy-3-(hydroxymethyl)-6-isopropyl-2-oxo-3-cyclohexen-1-yl 3-methylpentanoate	0
5-isopropyl-2-methyl-5-cyclohexene-1,2,4-triol	0
6-isopropyl-1-oxaspiro[2.5]octane	0
8-Hydroxycarvotanacetone	0
8-Mercapto-p-menthan-3-one	0
Acoric acid	0
Axisothiocyanate 3	0
Boydone A	0
Calacone	0
Carvotanacetone	0
Carvyl acetate	0
Diacetylgliocladic acid	0
Dihydrocarveol acetate	0
Ether, p-menth-6-en-2-yl methyl	0
Ethyl menthane carboxamide	0
Flammuspirone A	0
Flammuspirone B	0
Flammuspirone C	0
Flammuspirone D	0
Flammuspirone E	0
Flammuspirone F	0
Flammuspirone G	0
Flammuspirone H	0
Flammuspirone I	0
Flammuspirone J	0
Gamma-Diosphenol	0
Gliocladic acid	0
Graphostromabisabol B	0
Isocadinanol A	0
Isopulegol acetate	0
L-Menthone 1,2-glycerol ketal	0
L-Menthyl (R,S)-3-hydroxybutyrate	0
L-Menthyl acetoacetate	0
Limonene aldehyde	0
Menthone 1,2-glyceryl ketal	0
Menthone 1,3-glyceryl ketal	0
Menthyl ethylene glycol carbonate	0
Menthyl lactate	0
Menthyl pyrrolidone carboxylate	0
Monomenthyl succinate	0
Mycosphine A	0
Mycosphine B	0
Mycosphine C	0
Mycosphine D	0
Neomenthyl acetate	0
P-Mentha-6,8-dien-2-ol acetate	0
P-Meth-1-en-4-OL	0
Perillartine	0
Phellandral	0
Similin B	0
Spirotoamide C	0
Spirotoamide D	0
Terpinolene oxide	0
Terpinyl isobutyrate	0
Tetrahydrocarvone	0
Trichobisabolin D	0
Trichobisabolin E	0
Trichobisabolin F	0
Zopfiellin B	0
[5-Acetyloxy-3-(hydroxymethyl)-2-oxo-6-propan-2-ylcyclohex-3-en-1-yl] 3-methylbutanoate	0
[5-Acetyloxy-3-(hydroxymethyl)-2-oxo-6-propan-2-ylcyclohex-3-en-1-yl] 3-methylpentanoate	0
[5-Hydroxy-3-(hydroxymethyl)-2-oxo-6-propan-2-ylcyclohex-3-en-1-yl] 3-methylbutanoate	0
alpha-Terpineol butanoate	0
alpha-Terpineol formate	0
alpha-Terpineol propanoate	0
alpha-Terpinyl acetate	0
ascaridole	2
beta-Terpinyl acetate	0
carvacrol	41
carvones +	18
cineole +	78
cis- and trans-L-Mercapto-p-menthan-3-one	0
cis-2,8-Menthadien-2-ol	0
cis-6-Nitro-p-mentha-1(7),2-diene	0
cis-Piperitol	0
cis-p-Menthane-1,7,8-triol	0
delta-Terpineol	0
delta-terpineol acetate	0
dihydrocarveol +	0
gamma-Terpineol	0
gamma-Terpinyl acetate	0
isopiperitenol +	0
isopulegol	0
limonene monoterpenoid +	33
neo-isopulegol, rel-	0
p-Menth-1-en-9-ol acetate	0
p-Menth-3-en-9-al	0
p-Menth-3-ene-3-thiol	0
p-Mentha-1(6),8-dien-3-ol	0
p-Mentha-1,8-dien-4-ol	0
p-Menthan-4-ol	0
p-menth-4(8)-en-3-one +	1
p-menth-8-en-3-one +	0
p-menthadien-3-one +	0
p-menthan-1-ol	0
p-menthan-3-ol +	373
p-menthan-3-one +	3
p-menthane-3,8-diol +	0
piperitone +	0
s perillaldehyde	0
s perillic acid	0
sabinene hydrate	0
sabinol +	0
sobrerol	0
terpin	0
terpineol +	10
trans-2-Menthenol	0
trans-3-methyl-6-(1-methylethyl)-Cyclohexene	0
trans-Carvyl formate	0
trans-Dihydrocarvone	0
trans-p-Menth-2-ene-1,4-diol	0
trans-p-Menthane-1,8-diol	0
xi-p-Mentha-1(7),2-dien-4-ol	0
xi-p-Mentha-3,8-dien-1-ol	0
Path 2
Term	Annotations
CHEBI ontology	19932
subatomic particle	19930
composite particle	19930
hadron	19930
baryon	19930
nucleon	19930
atomic nucleus	19930
atom	19930
main group element atom	19876
main group molecular entity	19876
s-block molecular entity	19705
hydrogen molecular entity	19686
hydrides	19179
organic hydride	18717
organic fundamental parent	18717
hydrocarbon	18457
terpene	14071
terpenoid	13771
monoterpenoid	2045
p-menthane monoterpenoid	489
(+)-(6S)-hydroxymenthol	0
(+)-7-Hydroxymenthol	0
(+)-8-Acetoxycarvone	0
(+)-sabinone	0
(+)-trans-Piperitenol	0
(+)-trans-Pulegol	0
(+/-)-Menthyl acetate	0
(-)-Menthyl acetate	0
(-)-Pulegone	0
(1R,2R,4R,8R)-p-Menthane-2,8,9-triol	0
(1R,2R,4R,8S)-(-)-p-menthane-2,8,9-triol	0
(1R,2R,4S)-p-Menthane-1,2,8-triol	0
(1R,2S,3S,4R)-p-Menthane-2,3-diol	0
(1R,4R)-p-Mentha-2,8-dien-1-ol	0
(1R,4S)-1-hydroperoxy-p-menth-2-en-8-ol acetate	0
(1S,2S,4R,8R)-p-Menthane-1,2,8,9-tetrol	0
(1S,2S,4R,8R)-p-Menthane-1,2,9-triol	0
(1S,2S,4S)-p-menthane-1,2,4-triol	0
(1S,3R,4R)-p-Menthane-1,3-diol	0
(1S,4R)-p-Mentha-2,8-dien-1-ol	0
(1S,4S)-menthone-8-thioacetate	0
(1alpha,2alpha,4betaH,6alpha,8R)-p-Menthane-2,6,8,9-tetrol	0
(2S,4R)-p-Mentha-1(7),5-dien-2-ol	0
(2S,4R)-p-Mentha-1(7),8-dien-2-ol	0
(4R)-4-(1-methylethenyl)-1-cyclohexenecarboxylic acid	0
(4S,8R)-8,9-Dihydroxy-p-menth-1(6)-en-2-one	0
(7R)-1-hydroxy-3-p-menthen-9-oic acid	0
(7S)-1-hydroxy-3-p-menthen-9-oic acid	0
(E)-2-(Hydroxymethyl)-3-[(1S,2R,5S)-5-(hydroxymethyl)-2-propan-2-ylcyclohexyl]prop-2-enoic acid	0
(R)-2-Nitro-p-mentha-1,5-diene	0
(R)-p-Mentha-1,8-dien-10-ol	0
(S)-Oleuropeic acid	0
(S)-menthone 8-thioacetate	0
1(7),8(10)-p-Menthadien-9-ol	0
1,1,2-Trimethyl-3,5-bis(1-methylethenyl)cyclohexane	0
1,2-Dimethyl-3,5-bis(1-methylethenyl)cyclohexane	0
1-Ethoxy-p-menth-2-ene	0
1-Hydroxypropan-2-yl 2-isopropyl-5-methylcyclohexyl carbonate	0
1-Isopropyl-4-methylcyclohex-3-en-1-yl acetate	0
10alpha-4,5-Seco-11-eudesmene-4,5-dione	0
12-nor-11-acetoxybisabolen-3,6,7-triol	0
14-acetylgliocladic acid	0
2-(2-hydroxy-4-methylcyclohex-3-enyl)propanoic acid	0
2-(4-Methylcyclohex-3-en-1-yl)propane-2-thiol	0
2-(Hydroxymethyl)-3-[3-(hydroxymethyl)-6-propan-2-ylcyclohex-2-en-1-yl]prop-2-enoic acid	0
2-Hydroxy-p-mentha-1,8-dien-6-one	0
2-Hydroxypropyl 2-isopropyl-5-methylcyclohexyl carbonate	0
2-Menthene	0
2-p-Menthen-1-ol	0
3-(L-Menthoxy)-2-methylpropane-1,2-diol	0
3-Hydroxy-p-mentha-1,8-dien-7-al	0
3-[[5-Methyl-2-(1-methylethyl)cyclohexyl]oxy]-1,2-propanediol	0
3-acetylgliocladic acid	0
4-(2-Methoxypropan-2-yl)-1-methylcyclohex-1-ene	0
4-Isopropyl-3-cyclohexene-1-carboxylic acid	0
4-Methyl-2-methylene-1-(1methylethylidene)-cyclohexane	0
4-hydroxy-5-isopropenyl-2-methyl-2-cyclohexen-1-one	0
4-isopropylbenzyl alcohol	0
5,5-Diisopropyl-2,2'-dimethylbiphenyl-3,3',4,4'-tetrone	0
5-Isopropyl-2-(2-methylpropyl)-2-cyclohexen-1-one	0
5-hydroxy-3-(hydroxymethyl)-6-isopropyl-2-oxo-3-cyclohexen-1-yl 3-methylpentanoate	0
5-isopropyl-2-methyl-5-cyclohexene-1,2,4-triol	0
6-isopropyl-1-oxaspiro[2.5]octane	0
8-Hydroxycarvotanacetone	0
8-Mercapto-p-menthan-3-one	0
Acoric acid	0
Axisothiocyanate 3	0
Boydone A	0
Calacone	0
Carvotanacetone	0
Carvyl acetate	0
Diacetylgliocladic acid	0
Dihydrocarveol acetate	0
Ether, p-menth-6-en-2-yl methyl	0
Ethyl menthane carboxamide	0
Flammuspirone A	0
Flammuspirone B	0
Flammuspirone C	0
Flammuspirone D	0
Flammuspirone E	0
Flammuspirone F	0
Flammuspirone G	0
Flammuspirone H	0
Flammuspirone I	0
Flammuspirone J	0
Gamma-Diosphenol	0
Gliocladic acid	0
Graphostromabisabol B	0
Isocadinanol A	0
Isopulegol acetate	0
L-Menthone 1,2-glycerol ketal	0
L-Menthyl (R,S)-3-hydroxybutyrate	0
L-Menthyl acetoacetate	0
Limonene aldehyde	0
Menthone 1,2-glyceryl ketal	0
Menthone 1,3-glyceryl ketal	0
Menthyl ethylene glycol carbonate	0
Menthyl lactate	0
Menthyl pyrrolidone carboxylate	0
Monomenthyl succinate	0
Mycosphine A	0
Mycosphine B	0
Mycosphine C	0
Mycosphine D	0
Neomenthyl acetate	0
P-Mentha-6,8-dien-2-ol acetate	0
P-Meth-1-en-4-OL	0
Perillartine	0
Phellandral	0
Similin B	0
Spirotoamide C	0
Spirotoamide D	0
Terpinolene oxide	0
Terpinyl isobutyrate	0
Tetrahydrocarvone	0
Trichobisabolin D	0
Trichobisabolin E	0
Trichobisabolin F	0
Zopfiellin B	0
[5-Acetyloxy-3-(hydroxymethyl)-2-oxo-6-propan-2-ylcyclohex-3-en-1-yl] 3-methylbutanoate	0
[5-Acetyloxy-3-(hydroxymethyl)-2-oxo-6-propan-2-ylcyclohex-3-en-1-yl] 3-methylpentanoate	0
[5-Hydroxy-3-(hydroxymethyl)-2-oxo-6-propan-2-ylcyclohex-3-en-1-yl] 3-methylbutanoate	0
alpha-Terpineol butanoate	0