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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:melanins
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Accession:CHEBI:25179 term browser browse the term
Synonyms:alt_id: CHEBI:6727
 xref_mesh: MESH:D008543



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melanins term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor multiple interactions ISO Melanins inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein] CTD PMID:17077530 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
JBrowse link
G Atp7a ATPase copper transporting alpha multiple interactions ISO [TYR protein co-treated with ATP7A protein] results in increased abundance of Melanins CTD PMID:11092760 NCBI chr  X:71,094,144...71,201,550
Ensembl chr  X:71,094,202...71,198,354
JBrowse link
G Cldn3 claudin 3 multiple interactions ISO [CLDN3 protein results in increased abundance of Copper] promotes the reaction [[TYR protein results in increased oxidation of Levodopa] which results in increased chemical synthesis of Melanins] CTD PMID:23053666 NCBI chr12:21,708,538...21,710,010
Ensembl chr12:21,708,398...21,711,001
JBrowse link
G Cldn4 claudin 4 multiple interactions ISO [CLDN4 protein results in increased abundance of Copper] promotes the reaction [[TYR protein results in increased oxidation of Levodopa] which results in increased chemical synthesis of Melanins] CTD PMID:23053666 NCBI chr12:21,751,638...21,753,436
Ensembl chr12:21,751,331...21,753,436
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO Melanins inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]; Melanins inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 protein] CTD PMID:17077530 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Mc1r melanocortin 1 receptor multiple interactions ISO [Fenofibrate results in decreased expression of MC1R mRNA] which results in decreased chemical synthesis of Melanins CTD PMID:23872139 NCBI chr19:51,452,448...51,455,375 JBrowse link
G Pepd peptidase D multiple interactions
decreases activity
ISO Melanins inhibits the reaction [Gentamicins results in decreased activity of PEPD protein]
Melanins results in decreased activity of PEPD protein
CTD PMID:12098580 NCBI chr 1:87,536,650...87,681,233 JBrowse link
G Pld1 phospholipase D1 multiple interactions ISO [TYR protein results in decreased expression of and results in decreased activity of PLD1 protein] which results in decreased abundance of Melanins CTD PMID:14615486 NCBI chr 2:110,849,205...111,047,692
Ensembl chr 2:110,893,608...111,047,692
JBrowse link
G Pomc proopiomelanocortin increases chemical synthesis
multiple interactions
ISO POMC protein modified form results in increased chemical synthesis of Melanins
Quercetin analog inhibits the reaction [POMC protein modified form results in increased chemical synthesis of Melanins]
CTD PMID:26586997 NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664
JBrowse link
G Tyr tyrosinase multiple interactions ISO [CLDN3 protein results in increased abundance of Copper] promotes the reaction [[TYR protein results in increased oxidation of Levodopa] which results in increased chemical synthesis of Melanins]; [CLDN4 protein results in increased abundance of Copper] promotes the reaction [[TYR protein results in increased oxidation of Levodopa] which results in increased chemical synthesis of Melanins]; [Tetrachlorodibenzodioxin results in increased activity of TYR protein] which results in increased abundance of Melanins; [TYR protein co-treated with ATP7A protein] results in increased abundance of Melanins; [TYR protein results in decreased expression of and results in decreased activity of PLD1 protein] which results in decreased abundance of Melanins; [TYR protein results in increased oxidation of Levodopa] which results in increased chemical synthesis of Melanins
[Fenofibrate results in decreased chemical synthesis of Melanins] which results in decreased expression of TYR
CTD PMID:11092760 PMID:14615486 PMID:20973933 PMID:23053666 PMID:23872139 NCBI chr 1:141,115,036...141,210,207
Ensembl chr 1:141,115,036...141,210,207
JBrowse link
eumelanin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Asip agouti signaling protein affects chemical synthesis ISO A gene affects the chemical synthesis of eumelanin CTD PMID:8125260 NCBI chr 3:143,473,584...143,561,170
Ensembl chr 3:143,555,696...143,561,171
JBrowse link
G Dct dopachrome tautomerase decreases abundance ISO DCT gene mutant form results in decreased abundance of eumelanin CTD PMID:16584806 NCBI chr15:95,062,006...95,100,863
Ensembl chr15:95,062,003...95,100,836
JBrowse link
G Mc1r melanocortin 1 receptor increases chemical synthesis ISO MC1R protein results in increased chemical synthesis of eumelanin CTD PMID:24975581 NCBI chr19:51,452,448...51,455,375 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19800
    role 19751
      biological role 19751
        biophysical role 13180
          biological pigment 1078
            melanins 12
              1,8-dihydroxynaphthalene-melanin 0
              Melanin 0
              catechol melanin + 0
              eumelanin 3
Path 2
Term Annotations click to browse term
  CHEBI ontology 19800
    subatomic particle 19799
      composite particle 19799
        hadron 19799
          baryon 19799
            nucleon 19799
              atomic nucleus 19799
                atom 19799
                  main group element atom 19698
                    p-block element atom 19698
                      carbon group element atom 19619
                        carbon atom 19609
                          organic molecular entity 19609
                            organic molecule 19549
                              organic cyclic compound 19343
                                organic aromatic compound 19189
                                  phenols 18252
                                    polyphenol 6728
                                      melanins 12
                                        1,8-dihydroxynaphthalene-melanin 0
                                        Melanin 0
                                        catechol melanin + 0
                                        eumelanin 3
paths to the root