melanins - Ontology Report - Rat Genome Database

Submit Data | Help | Video Tutorials | News | Publications | Download | REST API | Citing RGD | Contact

CHEBI ONTOLOGY - ANNOTATIONS

{{ watchLinkText }}

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	melanins	go back to main search page
Accession:	CHEBI:25179	browse the term
Synonyms:	alt_id:	CHEBI:6727
	xref_mesh:	MESH:D008543

show annotations for term's descendants Sort by:
Rat (19) Mouse (19) Human (19) Chinchilla (0) Bonobo (0) Dog (0) Squirrel (0) Pig (0) Green Monkey (0) Naked Mole-rat (0) All
Genes (19)

melanins

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

aryl hydrocarbon receptor

multiple interactions

Melanins inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein]

NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568

G

ATPase copper transporting alpha

multiple interactions

[TYR protein co-treated with ATP7A protein] results in increased abundance of Melanins

NCBI chr X:71,094,144...71,201,550
Ensembl chr X:71,094,202...71,198,354

G

claudin 3

multiple interactions

[CLDN3 protein results in increased abundance of Copper] promotes the reaction [[TYR protein results in increased oxidation of Levodopa] which results in increased chemical synthesis of Melanins]

NCBI chr12:21,708,538...21,710,010
Ensembl chr12:21,708,398...21,711,001

G

claudin 4

multiple interactions

[CLDN4 protein results in increased abundance of Copper] promotes the reaction [[TYR protein results in increased oxidation of Levodopa] which results in increased chemical synthesis of Melanins]

NCBI chr12:21,751,638...21,753,436
Ensembl chr12:21,751,331...21,753,436

G

cytochrome P450, family 1, subfamily a, polypeptide 1

multiple interactions

Melanins inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]; Melanins inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 protein]

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

G

melanocortin 1 receptor

multiple interactions

[Fenofibrate results in decreased expression of MC1R mRNA] which results in decreased chemical synthesis of Melanins

NCBI chr19:51,452,448...51,455,375
Ensembl chr19:51,453,239...51,454,192

G

peptidase D

multiple interactions
decreases activity

Melanins inhibits the reaction [Gentamicins results in decreased activity of PEPD protein]
Melanins results in decreased activity of PEPD protein

NCBI chr 1:87,536,650...87,681,233
Ensembl chr 1:87,536,609...87,681,231

G

phospholipase D1

multiple interactions

[TYR protein results in decreased expression of and results in decreased activity of PLD1 protein] which results in decreased abundance of Melanins

NCBI chr 2:110,849,205...111,047,304
Ensembl chr 2:110,893,608...111,047,692

G

proopiomelanocortin

increases chemical synthesis
multiple interactions

POMC protein modified form results in increased chemical synthesis of Melanins
Quercetin analog inhibits the reaction [POMC protein modified form results in increased chemical synthesis of Melanins]

NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664

G

tyrosinase

multiple interactions

[CLDN3 protein results in increased abundance of Copper] promotes the reaction [[TYR protein results in increased oxidation of Levodopa] which results in increased chemical synthesis of Melanins]; [CLDN4 protein results in increased abundance of Copper] promotes the reaction [[TYR protein results in increased oxidation of Levodopa] which results in increased chemical synthesis of Melanins]; [Tetrachlorodibenzodioxin results in increased activity of TYR protein] which results in increased abundance of Melanins; [TYR protein co-treated with ATP7A protein] results in increased abundance of Melanins; [TYR protein results in decreased expression of and results in decreased activity of PLD1 protein] which results in decreased abundance of Melanins; [TYR protein results in increased oxidation of Levodopa] which results in increased chemical synthesis of Melanins
[Fenofibrate results in decreased chemical synthesis of Melanins] which results in decreased expression of TYR

PMID:11092760 PMID:14615486 PMID:20973933 PMID:23053666 PMID:23872139

NCBI chr 1:141,115,036...141,210,207
Ensembl chr 1:141,115,036...141,210,207

eumelanin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

agouti signaling protein

affects chemical synthesis

A gene affects the chemical synthesis of eumelanin

NCBI chr 3:143,473,584...143,561,170
Ensembl chr 3:143,555,696...143,561,171

G

caspase 3

multiple interactions

eumelanin inhibits the reaction [Diethylnitrosamine results in increased expression of CASP3 protein]

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

catalase

multiple interactions

eumelanin inhibits the reaction [Diethylnitrosamine results in decreased abundance of CAT protein]

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

dopachrome tautomerase

decreases abundance

DCT gene mutant form results in decreased abundance of eumelanin

NCBI chr15:95,062,006...95,100,863
Ensembl chr15:95,062,003...95,100,836

G

glutamic-oxaloacetic transaminase 1

multiple interactions

eumelanin inhibits the reaction [Diethylnitrosamine results in increased abundance of GOT1 protein]

NCBI chr 1:242,357,293...242,381,535
Ensembl chr 1:242,357,306...242,380,633

G

glutamic--pyruvic transaminase

multiple interactions

eumelanin inhibits the reaction [Diethylnitrosamine results in increased abundance of GPT protein]

NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494

G

interleukin 6

multiple interactions

eumelanin inhibits the reaction [Diethylnitrosamine results in increased expression of IL6 protein]

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

melanocortin 1 receptor

increases chemical synthesis

MC1R protein results in increased chemical synthesis of eumelanin

NCBI chr19:51,452,448...51,455,375
Ensembl chr19:51,453,239...51,454,192

G

proliferating cell nuclear antigen

multiple interactions

eumelanin inhibits the reaction [Diethylnitrosamine results in increased expression of PCNA protein]

NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995

G

tumor necrosis factor

multiple interactions

eumelanin inhibits the reaction [Diethylnitrosamine results in increased expression of TNF protein]

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	19831
role	19807
biological role	19805
biophysical role	14060
biological pigment	1124
melanins	19
1,8-dihydroxynaphthalene-melanin	0
Melanin	0
catechol melanin +	0
eumelanin	10
Path 2
Term	Annotations
CHEBI ontology	19831
subatomic particle	19829
composite particle	19829
hadron	19829
baryon	19829
nucleon	19829
atomic nucleus	19829
atom	19829
main group element atom	19779
p-block element atom	19779
carbon group element atom	19728
carbon atom	19724
organic molecular entity	19724
organic molecule	19677
organic cyclic compound	19490
organic aromatic compound	19359
phenols	18634
polyphenol	9423
melanins	19
1,8-dihydroxynaphthalene-melanin	0
Melanin	0
catechol melanin +	0
eumelanin	10

paths to the root