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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:manganese molecular entity
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Accession:CHEBI:25154 term browser browse the term
Synonyms:related_synonym: manganese compounds;   manganese molecular entities



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mancozeb term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase affects activity
multiple interactions
ISO mancozeb affects the activity of ACHE protein
[carbendazim co-treated with mancozeb] results in increased activity of ACHE protein
CTD PMID:10641187 PMID:33217513 NCBI chr 5:137,286,516...137,292,728
Ensembl chr 5:137,285,781...137,292,728
JBrowse link
G Actg1 actin, gamma, cytoplasmic 1 increases expression EXP mancozeb results in increased expression of ACTG1 protein CTD PMID:21375462 NCBI chr11:120,236,513...120,239,321
Ensembl chr11:120,236,516...120,239,368
JBrowse link
G Adam24 a disintegrin and metallopeptidase domain 24 (testase 1) increases expression ISO mancozeb results in increased expression of NPIPB11 mRNA CTD PMID:33396126 NCBI chr 8:41,128,118...41,135,238
Ensembl chr 8:41,128,118...41,135,238
JBrowse link
G Akt1 thymoma viral proto-oncogene 1 multiple interactions EXP [alachlor co-treated with Captan co-treated with Diazinon co-treated with Endosulfan co-treated with mancozeb co-treated with Maneb] affects the phosphorylation of AKT1 protein; [alachlor co-treated with Captan co-treated with Diazinon co-treated with Endosulfan co-treated with mancozeb co-treated with Maneb] results in decreased expression of AKT1 protein CTD PMID:19883720 NCBI chr12:112,620,255...112,641,318
Ensembl chr12:112,620,255...112,641,318
JBrowse link
G Alb albumin decreases expression EXP mancozeb results in decreased expression of ALB protein CTD PMID:21375462 NCBI chr 5:90,608,729...90,624,461
Ensembl chr 5:90,608,756...90,624,461
JBrowse link
G Aldh2 aldehyde dehydrogenase 2, mitochondrial decreases activity ISO mancozeb results in decreased activity of ALDH2 protein CTD PMID:17010440 NCBI chr 5:121,704,090...121,731,887
Ensembl chr 5:121,704,090...121,731,887
JBrowse link
G Aldh5a1 aldhehyde dehydrogenase family 5, subfamily A1 decreases activity ISO mancozeb results in decreased activity of ALDH5A1 protein CTD PMID:17010440 NCBI chr13:25,091,562...25,121,740
Ensembl chr13:25,091,562...25,121,644
JBrowse link
G Angptl1 angiopoietin-like 1 decreases expression ISO mancozeb results in decreased expression of ANGPTL1 mRNA CTD PMID:33396126 NCBI chr 1:156,666,593...156,688,648
Ensembl chr 1:156,666,132...156,688,648
JBrowse link
G Anxa2 annexin A2 decreases expression EXP mancozeb results in decreased expression of ANXA2 protein CTD PMID:21375462 NCBI chr 9:69,360,965...69,399,074
Ensembl chr 9:69,360,902...69,399,077
JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 increases expression ISO mancozeb results in increased expression of APAF1 protein CTD PMID:22289270 NCBI chr10:90,825,173...90,918,688
Ensembl chr10:90,825,173...90,918,632
JBrowse link
G Ar androgen receptor multiple interactions
decreases expression
decreases activity
ISO mancozeb inhibits the reaction [Dihydrotestosterone binds to and results in increased activity of AR protein]; mancozeb inhibits the reaction [Metribolone binds to and results in increased activity of AR protein]
mancozeb results in decreased expression of AR mRNA
mancozeb results in decreased activity of AR protein
CTD PMID:23871939 PMID:33396126 NCBI chr  X:97,192,363...97,366,824
Ensembl chr  X:97,192,375...97,366,821
JBrowse link
G Atp1a2 ATPase, Na+/K+ transporting, alpha 2 polypeptide decreases expression ISO mancozeb results in decreased expression of ATP1A2 mRNA CTD PMID:33396126 NCBI chr 1:172,099,276...172,125,631
Ensembl chr 1:172,099,276...172,125,631
JBrowse link
G Bax BCL2-associated X protein increases expression
multiple interactions
ISO mancozeb results in increased expression of BAX mRNA; mancozeb results in increased expression of BAX protein
lupeol inhibits the reaction [mancozeb results in increased expression of BAX mRNA]
CTD PMID:22289270 PMID:27235710 NCBI chr 7:45,111,119...45,116,344
Ensembl chr 7:45,111,121...45,116,322
JBrowse link
G BC024978 cDNA sequence BC024978 decreases expression ISO mancozeb results in decreased expression of C19ORF54 mRNA CTD PMID:33396126 NCBI chr 7:26,894,973...26,909,611
Ensembl chr 7:26,895,206...26,909,611
JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 decreases expression
multiple interactions
ISO mancozeb results in decreased expression of BCL2 mRNA; mancozeb results in decreased expression of BCL2 protein
lupeol inhibits the reaction [mancozeb results in decreased expression of BCL2 mRNA]
alpha-Tocopherol inhibits the reaction [mancozeb results in decreased expression of BCL2 protein]
CTD PMID:16005924 PMID:22289270 PMID:27235710 NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004
JBrowse link
G Car3 carbonic anhydrase 3 increases expression EXP mancozeb results in increased expression of CAR3 protein CTD PMID:21375462 NCBI chr 3:14,928,598...14,937,441
Ensembl chr 3:14,928,572...14,937,583
JBrowse link
G Casp3 caspase 3 increases activity
increases cleavage
multiple interactions
ISO
EXP
mancozeb results in increased activity of CASP3 protein
mancozeb results in increased cleavage of CASP3 protein
Acetylcysteine inhibits the reaction [mancozeb results in increased cleavage of CASP3 protein]
mancozeb results in increased cleavage of and results in increased activity of CASP3 protein
CTD PMID:22289270 PMID:22824503 PMID:30037311 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724
JBrowse link
G Casp7 caspase 7 increases activity ISO mancozeb results in increased activity of CASP7 protein CTD PMID:22824503 NCBI chr19:56,382,640...56,430,780
Ensembl chr19:56,385,561...56,430,776
JBrowse link
G Casp8 caspase 8 increases activity ISO mancozeb results in increased activity of CASP8 protein CTD PMID:22289270 PMID:22824503 NCBI chr 1:58,834,398...58,886,662
Ensembl chr 1:58,834,533...58,886,662
JBrowse link
G Casp9 caspase 9 increases activity
multiple interactions
ISO mancozeb results in increased activity of CASP9 protein
mancozeb results in increased cleavage of and results in increased activity of CASP9 protein
CTD PMID:22289270 PMID:22824503 NCBI chr 4:141,520,923...141,543,289
Ensembl chr 4:141,520,923...141,543,287
JBrowse link
G Cat catalase multiple interactions
decreases activity
ISO
EXP
Acetylcysteine inhibits the reaction [mancozeb results in decreased activity of CAT protein]; lupeol inhibits the reaction [mancozeb results in decreased activity of CAT protein]; Quercetin inhibits the reaction [mancozeb results in decreased activity of CAT protein]
Colforsin inhibits the reaction [mancozeb results in decreased activity of CAT protein]
CTD PMID:23024109 PMID:27235710 PMID:29283200 PMID:30037311 NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505
JBrowse link
G Ccdc106 coiled-coil domain containing 106 decreases expression ISO mancozeb results in decreased expression of CCDC106 mRNA CTD PMID:33396126 NCBI chr 7:5,056,847...5,063,784
Ensembl chr 7:5,023,552...5,063,784
JBrowse link
G Ccnd1 cyclin D1 multiple interactions
increases expression
EXP
ISO
[alachlor co-treated with Captan co-treated with Diazinon co-treated with Endosulfan co-treated with mancozeb co-treated with Maneb] results in increased expression of CCND1 protein
mancozeb results in increased expression of CCND1 protein
CTD PMID:19883720 PMID:21375462 NCBI chr 7:144,483,668...144,493,568
Ensembl chr 7:144,483,668...144,493,662
JBrowse link
G Cdc25c cell division cycle 25C increases phosphorylation ISO mancozeb results in increased phosphorylation of CDC25C protein CTD PMID:21375462 NCBI chr18:34,866,046...34,884,644
Ensembl chr18:34,866,046...34,884,586
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A (P21) multiple interactions
increases expression
ISO lupeol inhibits the reaction [mancozeb results in increased expression of CDKN1A mRNA] CTD PMID:27235710 NCBI chr17:29,309,953...29,319,696
Ensembl chr17:29,309,950...29,319,701
JBrowse link
G Cfap126 cilia and flagella associated protein 126 decreases expression ISO mancozeb results in decreased expression of CFAP126 mRNA CTD PMID:33396126 NCBI chr 1:170,941,326...170,954,525
Ensembl chr 1:170,941,487...170,954,536
JBrowse link
G Cldn16 claudin 16 decreases expression ISO mancozeb results in decreased expression of CLDN16 mRNA CTD PMID:33396126 NCBI chr16:26,281,885...26,301,515
Ensembl chr16:26,281,885...26,301,515
JBrowse link
G Ctf1 cardiotrophin 1 decreases expression ISO mancozeb results in decreased expression of CTF1 mRNA CTD PMID:33396126 NCBI chr 7:127,311,848...127,317,360
Ensembl chr 7:127,311,908...127,317,364
JBrowse link
G Cxcl15 chemokine (C-X-C motif) ligand 15 multiple interactions ISO mancozeb inhibits the reaction [Lipopolysaccharides results in increased secretion of CXCL8 protein] CTD PMID:16112155 NCBI chr 5:90,942,393...90,950,926
Ensembl chr 5:90,942,393...90,950,926
JBrowse link
G Cycs cytochrome c, somatic increases expression ISO mancozeb results in increased expression of CYCS protein CTD PMID:27016407 NCBI chr 6:50,539,543...50,543,549
Ensembl chr 6:50,539,543...50,543,518
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases activity
decreases expression
ISO mancozeb results in decreased activity of CYP1A1 protein
mancozeb results in decreased expression of CYP1A1 protein
CTD PMID:1946188 PMID:31096615 NCBI chr 9:57,595,211...57,611,107
Ensembl chr 9:57,595,211...57,611,107
JBrowse link
G Cyp2b10 cytochrome P450, family 2, subfamily b, polypeptide 10 decreases expression ISO mancozeb results in decreased expression of CYP2B6 protein CTD PMID:31096615 NCBI chr 7:25,597,083...25,626,049
Ensembl chr 7:25,597,045...25,626,049
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 decreases expression ISO mancozeb results in decreased expression of CYP2E1 mRNA CTD PMID:31096615 NCBI chr 7:140,343,732...140,354,903
Ensembl chr 7:140,343,652...140,354,900
JBrowse link
G Ddit4 DNA-damage-inducible transcript 4 increases expression ISO mancozeb results in increased expression of DDIT4 protein CTD PMID:24764117 NCBI chr10:59,785,497...59,787,592
Ensembl chr10:59,785,491...59,787,656
JBrowse link
G Efcab12 EF-hand calcium binding domain 12 decreases expression ISO mancozeb results in decreased expression of EFCAB12 mRNA CTD PMID:33396126 NCBI chr 6:115,787,690...115,815,536
Ensembl chr 6:115,787,690...115,815,373
JBrowse link
G Elk1 ELK1, member of ETS oncogene family increases phosphorylation ISO mancozeb results in increased phosphorylation of ELK1 protein CTD PMID:21375462 NCBI chr  X:20,799,634...20,816,847
Ensembl chr  X:20,799,634...20,816,847
JBrowse link
G Esr1 estrogen receptor 1 (alpha) decreases expression ISO mancozeb results in decreased expression of ESR1 mRNA CTD PMID:33396126 NCBI chr10:4,561,989...4,955,633
Ensembl chr10:4,561,593...4,955,614
JBrowse link
G Esr2 estrogen receptor 2 (beta) decreases expression ISO mancozeb results in decreased expression of ESR2 mRNA; mancozeb results in decreased expression of ESR2 protein CTD PMID:33396126 NCBI chr12:76,167,193...76,224,033
Ensembl chr12:76,167,193...76,224,033
JBrowse link
G F3 coagulation factor III increases expression ISO mancozeb results in increased expression of F3 protein CTD PMID:25569083 NCBI chr 3:121,517,186...121,528,701
Ensembl chr 3:121,517,186...121,528,697
JBrowse link
G Fas Fas (TNF receptor superfamily member 6) increases expression ISO mancozeb results in increased expression of FAS protein CTD PMID:22289270 NCBI chr19:34,267,926...34,305,175
Ensembl chr19:34,268,066...34,305,172
JBrowse link
G Fasl Fas ligand (TNF superfamily, member 6) increases expression ISO mancozeb results in increased expression of FASLG protein CTD PMID:22289270 NCBI chr 1:161,608,260...161,616,064
Ensembl chr 1:161,608,258...161,616,064
JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible 45 alpha increases expression
multiple interactions
ISO mancozeb results in increased expression of GADD45A mRNA
lupeol inhibits the reaction [mancozeb results in increased expression of GADD45A mRNA]
CTD PMID:27235710 NCBI chr 6:67,012,080...67,014,391
Ensembl chr 6:67,012,080...67,014,441
JBrowse link
G Glyatl3 glycine-N-acyltransferase-like 3 decreases expression ISO mancozeb results in decreased expression of GLYATL3 mRNA CTD PMID:33396126 NCBI chr17:41,215,618...41,231,606
Ensembl chr17:41,215,509...41,225,241
JBrowse link
G Gm11562 predicted gene 11562 decreases expression ISO mancozeb results in decreased expression of KRTAP2-2 mRNA CTD PMID:33396126 NCBI chr11:99,510,424...99,511,230
Ensembl chr11:99,510,445...99,511,261
JBrowse link
G Got1 glutamic-oxaloacetic transaminase 1, soluble affects activity ISO mancozeb affects the activity of GOT1 protein CTD PMID:10641187 NCBI chr19:43,488,191...43,514,743
Ensembl chr19:43,488,191...43,513,044
JBrowse link
G Gpt glutamic pyruvic transaminase, soluble affects activity ISO mancozeb affects the activity of GPT protein CTD PMID:10641187 NCBI chr15:76,580,926...76,583,875
Ensembl chr15:76,579,916...76,583,886
JBrowse link
G Gpx1 glutathione peroxidase 1 decreases expression
multiple interactions
EXP mancozeb results in decreased expression of GPX1 mRNA
Acetylcysteine inhibits the reaction [mancozeb results in decreased expression of GPX1 mRNA]
CTD PMID:30037311 NCBI chr 9:108,216,279...108,217,541
Ensembl chr 9:108,216,102...108,217,542
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions EXP [alachlor co-treated with Captan co-treated with Diazinon co-treated with Endosulfan co-treated with mancozeb co-treated with Maneb] affects the phosphorylation of GSK3B protein CTD PMID:19883720 NCBI chr16:37,909,363...38,066,446
Ensembl chr16:37,909,363...38,066,446
JBrowse link
G Hdac3 histone deacetylase 3 decreases activity ISO mancozeb results in decreased activity of HDAC3 protein CTD PMID:21251949 NCBI chr18:38,070,024...38,088,073
Ensembl chr18:38,068,897...38,088,069
JBrowse link
G Hdac6 histone deacetylase 6 decreases activity ISO mancozeb results in decreased activity of HDAC6 protein CTD PMID:21251949 NCBI chr  X:7,796,355...7,814,284
Ensembl chr  X:7,796,359...7,814,128
JBrowse link
G Hnrnpm heterogeneous nuclear ribonucleoprotein M increases expression EXP mancozeb results in increased expression of HNRNPM protein CTD PMID:21375462 NCBI chr17:33,865,207...33,904,432
Ensembl chr17:33,865,207...33,905,834
JBrowse link
G Ifitm2 interferon induced transmembrane protein 2 decreases expression ISO mancozeb results in decreased expression of IFITM2 mRNA CTD PMID:33396126 NCBI chr 7:140,534,750...140,539,602
Ensembl chr 7:140,534,750...140,535,900
JBrowse link
G Ifng interferon gamma multiple interactions EXP mancozeb affects the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased secretion of TNF protein] CTD PMID:15742816 NCBI chr10:118,276,951...118,281,799
Ensembl chr10:118,276,951...118,281,797
JBrowse link
G Ighm immunoglobulin heavy constant mu increases expression ISO mancozeb results in increased expression of IGHM mRNA CTD PMID:33396126 NCBI chr12:113,382,446...113,386,350
Ensembl chr12:113,382,178...113,386,350
JBrowse link
G Ighv5-4 immunoglobulin heavy variable 5-4 decreases expression ISO mancozeb results in decreased expression of IGHV3-38 mRNA CTD PMID:33396126 NCBI chr12:113,561,068...113,561,361
Ensembl chr12:113,561,066...113,561,597
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO mancozeb inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein] CTD PMID:16112155 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059
JBrowse link
G Il2 interleukin 2 affects expression ISO mancozeb affects the expression of IL2 protein CTD PMID:9012323 NCBI chr 3:37,174,862...37,180,103
Ensembl chr 3:37,174,672...37,180,108
JBrowse link
G Itgb3 integrin beta 3 decreases expression ISO mancozeb results in decreased expression of ITGB3 mRNA; mancozeb results in decreased expression of ITGB3 protein CTD PMID:33396126 NCBI chr11:104,498,826...104,561,302
Ensembl chr11:104,498,826...104,561,302
JBrowse link
G Kcnq2 potassium voltage-gated channel, subfamily Q, member 2 increases activity ISO mancozeb results in increased activity of KCNQ2 protein CTD PMID:23542819 NCBI chr 2:180,717,372...180,777,368
Ensembl chr 2:180,717,372...180,777,093
JBrowse link
G Kiss1 KiSS-1 metastasis-suppressor affects expression ISO mancozeb affects the expression of KISS1 mRNA CTD PMID:23660487 NCBI chr 1:133,249,625...133,257,460
Ensembl chr 1:133,237,565...133,257,460
Ensembl chr 1:133,237,565...133,257,460
JBrowse link
G Krt6a keratin 6A decreases expression EXP mancozeb results in decreased expression of KRT6A protein CTD PMID:21375462 NCBI chr15:101,598,363...101,602,740
Ensembl chr15:101,598,345...101,602,742
JBrowse link
G Ltb4r2 leukotriene B4 receptor 2 increases expression ISO mancozeb results in increased expression of LTB4R2 mRNA CTD PMID:33396126 NCBI chr14:55,995,379...56,001,523
Ensembl chr14:55,998,885...56,002,595
JBrowse link
G Mapk1 mitogen-activated protein kinase 1 multiple interactions ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [mancozeb results in increased activity of MAPK1 protein]; mancozeb results in increased localization of and results in increased activity of MAPK1 protein CTD PMID:21375462 NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317
JBrowse link
G Mapk3 mitogen-activated protein kinase 3 multiple interactions ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [mancozeb results in increased activity of MAPK3 protein]; mancozeb results in increased localization of and results in increased activity of MAPK3 protein CTD PMID:21375462 NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991
JBrowse link
G Mdm2 transformed mouse 3T3 cell double minute 2 increases expression
multiple interactions
ISO mancozeb results in increased expression of MDM2 mRNA
lupeol inhibits the reaction [mancozeb results in increased expression of MDM2 mRNA]
CTD PMID:27235710 NCBI chr10:117,524,780...117,546,663
Ensembl chr10:117,524,780...117,546,663
JBrowse link
G Mir421 microRNA 421 increases expression ISO mancozeb results in increased expression of MIR421 mRNA CTD PMID:33396126 NCBI chr  X:102,616,527...102,616,602
Ensembl chr  X:102,616,527...102,616,602
JBrowse link
G Muc1 mucin 1, transmembrane decreases expression ISO mancozeb results in decreased expression of MUC1 mRNA; mancozeb results in decreased expression of MUC1 protein CTD PMID:33396126 NCBI chr 3:89,136,363...89,140,688
Ensembl chr 3:89,136,364...89,140,688
JBrowse link
G Myc myelocytomatosis oncogene multiple interactions
increases expression
decreases expression
EXP
ISO
[alachlor co-treated with Captan co-treated with Diazinon co-treated with Endosulfan co-treated with mancozeb co-treated with Maneb] results in increased expression of MYC protein
mancozeb results in increased expression of MYC protein
mancozeb results in decreased expression of MYC protein
alpha-Tocopherol inhibits the reaction [mancozeb results in decreased expression of MYC protein]
CTD PMID:16005924 PMID:19883720 NCBI chr15:61,857,190...61,862,210
Ensembl chr15:61,857,240...61,862,223
JBrowse link
G Nhlrc1 NHL repeat containing 1 decreases expression ISO mancozeb results in decreased expression of NHLRC1 mRNA CTD PMID:33396126 NCBI chr13:47,166,033...47,168,326
Ensembl chr13:47,166,033...47,168,326
JBrowse link
G Nos2 nitric oxide synthase 2, inducible multiple interactions
increases expression
EXP Acetylcysteine inhibits the reaction [mancozeb results in increased expression of NOS2 mRNA] CTD PMID:30037311 NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080
JBrowse link
G Nox4 NADPH oxidase 4 multiple interactions
increases expression
EXP Acetylcysteine inhibits the reaction [mancozeb results in increased expression of NOX4 mRNA] CTD PMID:30037311 NCBI chr 7:86,893,638...87,047,918
Ensembl chr 7:86,895,304...87,047,918
JBrowse link
G Odc1 ornithine decarboxylase, structural 1 increases activity EXP mancozeb results in increased activity of ODC1 protein CTD PMID:1733566 NCBI chr12:17,594,809...17,601,503
Ensembl chr12:17,594,795...17,601,506
JBrowse link
G Ogg1 8-oxoguanine DNA-glycosylase 1 decreases expression
multiple interactions
ISO mancozeb results in decreased expression of OGG1 mRNA
lupeol inhibits the reaction [mancozeb results in decreased expression of OGG1 mRNA]
CTD PMID:27235710 NCBI chr 6:113,303,871...113,311,838
Ensembl chr 6:113,303,933...113,312,029
JBrowse link
G Pcdhb20 protocadherin beta 20 decreases expression ISO mancozeb results in decreased expression of PCDHB14 mRNA CTD PMID:33396126 NCBI chr18:37,637,317...37,640,713
Ensembl chr18:37,637,317...37,640,875
JBrowse link
G Prdx2 peroxiredoxin 2 increases expression EXP mancozeb results in increased expression of PRDX2 protein CTD PMID:21375462 NCBI chr 8:85,696,251...85,701,440
Ensembl chr 8:85,696,216...85,701,463
JBrowse link
G Prl prolactin multiple interactions
increases expression
EXP
ISO
[mancozeb co-treated with imidacloprid] results in increased expression of PRL protein
mancozeb results in increased expression of PRL mRNA
CTD PMID:24530807 PMID:33396126 NCBI chr13:27,241,553...27,249,187
Ensembl chr13:27,241,553...27,249,188
JBrowse link
G Ptges prostaglandin E synthase increases expression
decreases expression
multiple interactions
ISO
EXP
mancozeb results in increased expression of PTGES mRNA
mancozeb results in decreased expression of PTGES protein
lupeol inhibits the reaction [mancozeb results in increased expression of PTGES mRNA]
CTD PMID:27235710 PMID:32446389 NCBI chr 2:30,779,483...30,793,309
Ensembl chr 2:30,779,483...30,819,875
JBrowse link
G Ptges3 prostaglandin E synthase 3 decreases expression EXP mancozeb results in decreased expression of PTGES3 mRNA CTD PMID:32446389 NCBI chr10:127,894,851...127,913,123
Ensembl chr10:127,894,823...127,913,141
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression ISO
EXP
mancozeb results in increased expression of PTGS2 protein CTD PMID:21375462 PMID:32446389 NCBI chr 1:149,975,782...149,983,985
Ensembl chr 1:149,975,782...149,983,978
JBrowse link
G Ptk2b PTK2 protein tyrosine kinase 2 beta multiple interactions EXP [alachlor co-treated with Captan co-treated with Diazinon co-treated with Endosulfan co-treated with mancozeb co-treated with Maneb] results in decreased expression of PTK2B protein modified form CTD PMID:19883720 NCBI chr14:66,390,706...66,518,549
Ensembl chr14:66,390,706...66,518,501
JBrowse link
G Pvalb parvalbumin increases expression EXP mancozeb results in increased expression of PVALB protein CTD PMID:21375462 NCBI chr15:78,075,312...78,090,600
Ensembl chr15:78,075,314...78,090,600
JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) increases phosphorylation
affects localization
multiple interactions
increases localization
ISO mancozeb results in increased phosphorylation of RELA protein
mancozeb affects the localization of RELA protein
Acetylcysteine inhibits the reaction [mancozeb affects the localization of RELA protein]; lupeol inhibits the reaction [mancozeb affects the localization of RELA protein]; mancozeb inhibits the reaction [Lipopolysaccharides affects the localization of and results in increased activity of RELA protein]
mancozeb results in increased localization of RELA protein
CTD PMID:16112155 PMID:21375462 PMID:22289270 PMID:27235710 NCBI chr19:5,687,569...5,698,162
Ensembl chr19:5,687,511...5,698,158
JBrowse link
G S100a6 S100 calcium binding protein A6 (calcyclin) increases expression EXP
ISO
mancozeb results in increased expression of S100A6 protein CTD PMID:21375462 NCBI chr 3:90,520,201...90,521,721
Ensembl chr 3:90,520,189...90,531,488
JBrowse link
G S100a9 S100 calcium binding protein A9 (calgranulin B) increases expression EXP
ISO
mancozeb results in increased expression of S100A9 protein CTD PMID:21375462 NCBI chr 3:90,599,937...90,603,028
Ensembl chr 3:90,599,939...90,603,028
JBrowse link
G Scx scleraxis decreases expression ISO mancozeb results in decreased expression of SCX mRNA CTD PMID:33396126 NCBI chr15:76,341,594...76,343,668
Ensembl chr15:76,341,652...76,343,658
JBrowse link
G Septin11 septin 11 increases expression ISO mancozeb results in increased expression of SEPTIN11 mRNA CTD PMID:33396126 NCBI chr 5:93,227,445...93,329,237
Ensembl chr 5:93,241,296...93,324,306
JBrowse link
G Serpinf1 serine (or cysteine) peptidase inhibitor, clade F, member 1 decreases expression ISO mancozeb results in decreased expression of SERPINF1 mRNA CTD PMID:33396126 NCBI chr11:75,300,855...75,313,449
Ensembl chr11:75,300,595...75,313,527
JBrowse link
G Sirt1 sirtuin 1 decreases activity ISO mancozeb results in decreased activity of SIRT1 protein CTD PMID:21251949 NCBI chr10:63,154,784...63,174,814
Ensembl chr10:63,154,784...63,217,483
JBrowse link
G Sirt2 sirtuin 2 decreases activity ISO mancozeb results in decreased activity of SIRT2 protein CTD PMID:21251949 NCBI chr 7:28,466,177...28,488,090
Ensembl chr 7:28,466,160...28,488,086
JBrowse link
G Sirt3 sirtuin 3 decreases activity ISO mancozeb results in decreased activity of SIRT3 protein CTD PMID:21251949 NCBI chr 7:140,443,576...140,462,222
Ensembl chr 7:140,443,579...140,462,222
JBrowse link
G Slc14a1 solute carrier family 14 (urea transporter), member 1 decreases expression ISO mancozeb results in decreased expression of SLC14A1 mRNA CTD PMID:33396126 NCBI chr18:78,143,306...78,185,334
Ensembl chr18:78,143,306...78,185,334
JBrowse link
G Slc5a5 solute carrier family 5 (sodium iodide symporter), member 5 multiple interactions ISO mancozeb inhibits the reaction [SLC5A5 protein results in increased uptake of Iodine] CTD PMID:27979590 NCBI chr 8:71,335,529...71,345,429
Ensembl chr 8:71,335,533...71,345,401
JBrowse link
G Snord82 small nucleolar RNA, C/D box 82 increases expression ISO mancozeb results in increased expression of SNORD82 mRNA CTD PMID:33396126 NCBI chr 1:86,283,982...86,284,049
Ensembl chr 1:86,283,983...86,284,052
JBrowse link
G Sod1 superoxide dismutase 1, soluble decreases expression EXP mancozeb results in decreased expression of SOD1 protein CTD PMID:21375462 NCBI chr16:90,017,650...90,023,221
Ensembl chr16:90,017,642...90,023,217
JBrowse link
G Stfa3 stefin A3 increases expression EXP mancozeb results in increased expression of STFA3 protein CTD PMID:21375462 NCBI chr16:36,270,899...36,275,754
Ensembl chr16:36,270,899...36,275,754
JBrowse link
G Sult2b1 sulfotransferase family, cytosolic, 2B, member 1 decreases expression ISO mancozeb results in decreased expression of SULT2B1 mRNA CTD PMID:33396126 NCBI chr 7:45,379,405...45,409,096
Ensembl chr 7:45,379,407...45,434,093
JBrowse link
G Tek TEK receptor tyrosine kinase increases activity ISO mancozeb results in increased activity of TEK protein CTD PMID:21251949 NCBI chr 4:94,627,322...94,763,213
Ensembl chr 4:94,627,526...94,763,213
JBrowse link
G Tgfb1i1 transforming growth factor beta 1 induced transcript 1 decreases expression ISO mancozeb results in decreased expression of TGFB1I1 mRNA CTD PMID:33396126 NCBI chr 7:127,845,963...127,854,871
Ensembl chr 7:127,845,984...127,854,871
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP
ISO
mancozeb affects the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased secretion of TNF protein]
mancozeb inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; mancozeb inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; mancozeb inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of TNF protein]
CTD PMID:15742816 PMID:15893782 PMID:16112155 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983
JBrowse link
G Tpi1 triosephosphate isomerase 1 increases expression EXP mancozeb results in increased expression of TPI1 protein CTD PMID:21375462 NCBI chr 6:124,787,549...124,791,121
Ensembl chr 6:124,787,549...124,791,259
JBrowse link
G Tpo thyroid peroxidase decreases activity ISO mancozeb results in decreased activity of TPO protein CTD PMID:9418944 NCBI chr12:30,104,658...30,182,983
Ensembl chr12:30,104,658...30,182,623
JBrowse link
G Trp53 transformation related protein 53 decreases expression
increases expression
multiple interactions
ISO
EXP
mancozeb results in decreased expression of TRP53 mRNA; mancozeb results in decreased expression of TRP53 protein
mancozeb results in increased expression of TP53 mRNA
lupeol inhibits the reaction [mancozeb results in increased expression of TP53 mRNA]
CTD PMID:22369882 PMID:27235710 NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699
JBrowse link
G Tshb thyroid stimulating hormone, beta subunit multiple interactions EXP [mancozeb co-treated with imidacloprid] results in increased expression of TSHB protein CTD PMID:24530807 NCBI chr 3:102,684,621...102,718,175
Ensembl chr 3:102,682,781...102,690,034
JBrowse link
G Xrcc1 X-ray repair complementing defective repair in Chinese hamster cells 1 decreases expression
multiple interactions
ISO mancozeb results in decreased expression of XRCC1 mRNA
lupeol inhibits the reaction [mancozeb results in decreased expression of XRCC1 mRNA]
CTD PMID:27235710 NCBI chr 7:24,246,124...24,272,863
Ensembl chr 7:24,245,714...24,272,865
JBrowse link
G Zfp358 zinc finger protein 358 decreases expression ISO mancozeb results in decreased expression of ZNF358 mRNA CTD PMID:33396126 NCBI chr 8:3,543,138...3,547,208
Ensembl chr 8:3,543,138...3,547,208
JBrowse link
maneb term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acads acyl-Coenzyme A dehydrogenase, short chain multiple interactions EXP [Maneb co-treated with Paraquat] results in decreased expression of ACADS mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of ACADS mRNA]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of ACADS mRNA] CTD PMID:23963992 NCBI chr 5:115,248,358...115,257,405
Ensembl chr 5:115,248,358...115,257,405
JBrowse link
G Ache acetylcholinesterase multiple interactions
decreases expression
EXP
ISO
[LRRK2 protein mutant form co-treated with Maneb co-treated with Paraquat] results in decreased expression of ACHE mRNA
Maneb results in decreased expression of ACHE protein
CTD PMID:3868355 PMID:23017109 NCBI chr 5:137,286,516...137,292,728
Ensembl chr 5:137,285,781...137,292,728
JBrowse link
G Aco2 aconitase 2, mitochondrial multiple interactions EXP [Paraquat co-treated with Maneb] results in decreased expression of ACO2 mRNA CTD PMID:18386188 NCBI chr15:81,756,664...81,799,338
Ensembl chr15:81,756,510...81,799,334
JBrowse link
G Adam22 a disintegrin and metallopeptidase domain 22 multiple interactions EXP [Paraquat co-treated with Maneb] affects the expression of ADAM22 mRNA CTD PMID:22563483 NCBI chr 5:8,122,347...8,418,312
Ensembl chr 5:8,122,352...8,418,160
JBrowse link
G Adgrb1 adhesion G protein-coupled receptor B1 multiple interactions EXP [Maneb co-treated with Paraquat] results in decreased expression of ADGRB1 mRNA CTD PMID:23017109 NCBI chr15:74,388,045...74,461,314
Ensembl chr15:74,388,044...74,461,314
JBrowse link
G Adgrg1 adhesion G protein-coupled receptor G1 multiple interactions EXP [Paraquat co-treated with Maneb] results in decreased expression of ADGRG1 mRNA CTD PMID:18386188 NCBI chr 8:95,701,384...95,740,836
Ensembl chr 8:95,701,379...95,740,845
JBrowse link
G Adora1 adenosine A1 receptor multiple interactions EXP [SNCA protein co-treated with Maneb co-treated with Paraquat] results in decreased expression of ADORA1 mRNA CTD PMID:23017109 NCBI chr 1:134,126,953...134,163,195
Ensembl chr 1:134,126,961...134,163,169
JBrowse link
G Ago3 argonaute RISC catalytic subunit 3 multiple interactions EXP [Paraquat co-treated with Maneb] affects the expression of AGO3 mRNA CTD PMID:22563483 NCBI chr 4:126,220,797...126,323,360
Ensembl chr 4:126,225,497...126,323,349
JBrowse link
G Aif1 allograft inflammatory factor 1 multiple interactions EXP [Maneb co-treated with Paraquat] results in increased expression of AIF1 protein; [Paraquat co-treated with Maneb] results in increased expression of AIF1 protein; acetovanillone inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of AIF1 protein]; Glyburide inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of AIF1 protein] CTD PMID:28202386 PMID:32375810 NCBI chr17:35,389,962...35,395,050
Ensembl chr17:35,389,967...35,395,044
JBrowse link
G Akr1b3 aldo-keto reductase family 1, member B3 (aldose reductase) multiple interactions EXP [Paraquat co-treated with Maneb] results in decreased expression of AKR1B3 mRNA CTD PMID:18386188 NCBI chr 6:34,280,865...34,294,424
Ensembl chr 6:34,279,369...34,294,413
JBrowse link
G Akt1 thymoma viral proto-oncogene 1 multiple interactions EXP [alachlor co-treated with Captan co-treated with Diazinon co-treated with Endosulfan co-treated with mancozeb co-treated with Maneb] affects the phosphorylation of AKT1 protein; [alachlor co-treated with Captan co-treated with Diazinon co-treated with Endosulfan co-treated with mancozeb co-treated with Maneb] results in decreased expression of AKT1 protein; [Maneb co-treated with Paraquat] results in decreased expression of AKT1 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of AKT1 mRNA]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of AKT1 mRNA] CTD PMID:19883720 PMID:23963992 NCBI chr12:112,620,255...112,641,318
Ensembl chr12:112,620,255...112,641,318
JBrowse link
G Alas2 aminolevulinic acid synthase 2, erythroid multiple interactions EXP [Paraquat co-treated with Maneb] affects the expression of ALAS2 mRNA CTD PMID:22563483 NCBI chr  X:149,330,413...149,353,618
Ensembl chr  X:149,330,371...149,353,634
JBrowse link
G Aldh2 aldehyde dehydrogenase 2, mitochondrial decreases activity ISO Maneb results in decreased activity of ALDH2 protein CTD PMID:17010440 NCBI chr 5:121,704,090...121,731,887
Ensembl chr 5:121,704,090...121,731,887
JBrowse link
G Aldh5a1 aldhehyde dehydrogenase family 5, subfamily A1 decreases activity
multiple interactions
ISO
EXP
Maneb results in decreased activity of ALDH5A1 protein
[Maneb co-treated with Paraquat] results in decreased expression of ALDH5A1 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of ALDH5A1 mRNA]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of ALDH5A1 mRNA]
CTD PMID:17010440 PMID:23963992 NCBI chr13:25,091,562...25,121,740
Ensembl chr13:25,091,562...25,121,644
JBrowse link
G Aldoc aldolase C, fructose-bisphosphate multiple interactions EXP [Paraquat co-treated with Maneb] results in decreased expression of ALDOC mRNA CTD PMID:18386188 NCBI chr11:78,213,899...78,218,607
Ensembl chr11:78,213,794...78,218,607
JBrowse link
G Amn amnionless multiple interactions EXP [Paraquat co-treated with Maneb] affects the expression of AMN mRNA CTD PMID:22563483 NCBI chr12:111,237,530...111,242,860
Ensembl chr12:111,237,529...111,242,860
JBrowse link
G Ap3b2 adaptor-related protein complex 3, beta 2 subunit multiple interactions EXP [Paraquat co-treated with Maneb] results in decreased expression of AP3B2 mRNA CTD PMID:18386188 NCBI chr 7:81,110,147...81,143,722
Ensembl chr 7:81,110,147...81,143,673
JBrowse link
G Ap3d1 adaptor-related protein complex 3, delta 1 subunit multiple interactions EXP [Paraquat co-treated with Maneb] results in decreased expression of AP3D1 mRNA CTD PMID:18386188 NCBI chr10:80,542,790...80,578,137
Ensembl chr10:80,542,790...80,578,098
JBrowse link
G Apbb1 amyloid beta (A4) precursor protein-binding, family B, member 1 multiple interactions EXP [SNCA protein co-treated with Maneb co-treated with Paraquat] results in decreased expression of APBB1 mRNA CTD PMID:23017109 NCBI chr 7:105,207,672...105,231,151
Ensembl chr 7:105,207,690...105,230,860
JBrowse link
G Arf3 ADP-ribosylation factor 3 multiple interactions EXP [Paraquat co-treated with Maneb] results in decreased expression of ARF3 mRNA CTD PMID:18386188 NCBI chr15:98,635,505...98,660,999
Ensembl chr15:98,634,515...98,661,095
JBrowse link
G Arg1 arginase, liver multiple interactions
decreases expression
EXP
ISO
[Maneb co-treated with Paraquat] results in increased expression of ARG1 mRNA; [Paraquat co-treated with Maneb] results in increased expression of ARG1 mRNA; Glyburide inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of ARG1 mRNA]
Maneb results in decreased expression of ARG1 mRNA
CTD PMID:29568078 PMID:32194361 PMID:32375810 PMID:34052309 NCBI chr10:24,791,105...24,803,368
Ensembl chr10:24,791,119...24,803,382
JBrowse link
G Arnt2 aryl hydrocarbon receptor nuclear translocator 2 multiple interactions EXP [Maneb co-treated with Paraquat] results in increased expression of ARNT2 mRNA CTD PMID:23017109 NCBI chr 7:83,895,482...84,060,949
Ensembl chr 7:83,895,486...84,059,384
JBrowse link
G Ascl1 achaete-scute family bHLH transcription factor 1 multiple interactions EXP [SNCA protein co-treated with Maneb co-treated with Paraquat] results in decreased expression of ASCL1 mRNA CTD PMID:23017109 NCBI chr10:87,326,681...87,329,522
Ensembl chr10:87,326,681...87,329,522
JBrowse link
G Atg12 autophagy related 12 multiple interactions EXP Maneb promotes the reaction [Paraquat results in increased expression of ATG12 protein] CTD PMID:22292029 NCBI chr18:46,865,484...46,874,683
Ensembl chr18:46,863,211...46,874,647
JBrowse link
G Atp5a1 ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1 multiple interactions EXP [Maneb co-treated with Paraquat] results in decreased expression of ATP5A1 protein; Minocycline inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of ATP5A1 protein]; tetrakis(N-methyl-4-pyridiniumyl)porphine manganese(III) complex inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of ATP5A1 protein] CTD PMID:23562983 NCBI chr18:77,861,468...77,870,569
Ensembl chr18:77,861,429...77,870,569
JBrowse link
G Atp5g1 ATP synthase, H+ transporting, mitochondrial F0 complex, subunit C1 (subunit 9) multiple interactions EXP [Paraquat co-treated with Maneb] results in decreased expression of ATP5G1 mRNA CTD PMID:18386188 NCBI chr11:95,963,619...95,966,520
Ensembl chr11:95,959,678...95,966,496
JBrowse link
G Atp6v0b ATPase, H+ transporting, lysosomal V0 subunit B multiple interactions EXP [Paraquat co-treated with Maneb] results in decreased expression of ATP6V0B mRNA CTD PMID:18386188 NCBI chr 4:117,741,523...117,744,548
Ensembl chr 4:117,741,523...117,744,530
JBrowse link
G Atp6v0c ATPase, H+ transporting, lysosomal V0 subunit C multiple interactions EXP [Paraquat co-treated with Maneb] results in decreased expression of ATP6V0C mRNA CTD PMID:18386188 NCBI chr17:24,382,839...24,388,652
Ensembl chr17:24,382,840...24,388,676
JBrowse link
G Atp6v1c1 ATPase, H+ transporting, lysosomal V1 subunit C1 multiple interactions EXP [Maneb co-treated with Paraquat] results in decreased expression of ATP6V1C1 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of ATP6V1C1 mRNA]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of ATP6V1C1 mRNA] CTD PMID:23963992 NCBI chr15:38,662,096...38,692,688
Ensembl chr15:38,662,177...38,692,690
JBrowse link
G Atp8a2 ATPase, aminophospholipid transporter-like, class I, type 8A, member 2 multiple interactions EXP [Paraquat co-treated with Maneb] affects the expression of ATP8A2 mRNA CTD PMID:22563483 NCBI chr14:59,884,980...60,324,363
Ensembl chr14:59,875,989...60,434,628
JBrowse link
G Bad BCL2-associated agonist of cell death multiple interactions ISO [Paraquat co-treated with Maneb] results in increased phosphorylation of BAD protein CTD PMID:15824117 NCBI chr19:6,919,229...6,929,273
Ensembl chr19:6,919,229...6,929,267
JBrowse link
G Bak1 BCL2-antagonist/killer 1 multiple interactions
increases expression
affects response to substance
EXP
ISO
[Maneb co-treated with Paraquat] results in increased expression of BAK1 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of BAK1 mRNA]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of BAK1 mRNA]
[Paraquat co-treated with Maneb] results in increased expression of BAK1 protein; Maneb inhibits the reaction [BAK1 protein affects the susceptibility to Paraquat]; Paraquat inhibits the reaction [BAK1 protein affects the susceptibility to Maneb]
Maneb results in increased expression of BAK1 mRNA; Maneb results in increased expression of BAK1 protein
CTD PMID:18266926 PMID:23963992 NCBI chr17:27,238,786...27,247,601
Ensembl chr17:27,238,784...27,247,983
JBrowse link
G Bax BCL2-associated X protein multiple interactions
increases expression
ISO
EXP
[Paraquat co-treated with Maneb] results in increased expression of BAX protein; BAX protein affects the susceptibility to [Paraquat co-treated with Maneb]
Maneb results in increased expression of BAX protein
[Maneb co-treated with Paraquat] results in increased expression of BAX mRNA; [Paraquat co-treated with Maneb] results in increased expression of BAX protein; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of BAX mRNA]; Melatonin inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of BAX protein]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of BAX mRNA]; Silymarin inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of BAX protein]
CTD PMID:15824117 PMID:18266926 PMID:20964710 PMID:23963992 NCBI chr 7:45,111,119...45,116,344
Ensembl chr 7:45,111,121...45,116,322
JBrowse link
G Bbc3 BCL2 binding component 3 increases expression ISO Maneb results in increased expression of BBC3 protein CTD PMID:18266926 NCBI chr 7:16,042,307...16,052,259
Ensembl chr 7:16,042,318...16,052,130
JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 multiple interactions
increases expression
EXP
ISO
[Maneb co-treated with Paraquat] results in decreased expression of BCL2 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of BCL2 mRNA]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of BCL2 mRNA]
Maneb results in increased expression of BCL2 mRNA; Maneb results in increased expression of BCL2 protein
CTD PMID:18266926 PMID:23963992 NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004
JBrowse link
G Bcl2a1b B cell leukemia/lymphoma 2 related protein A1b multiple interactions
increases expression
ISO [Paraquat co-treated with Maneb] results in increased expression of BCL2A1 protein
Maneb results in increased expression of BCL2A1 mRNA
CTD PMID:18266926 NCBI chr 9:89,081,326...89,089,891
Ensembl chr 9:89,081,262...89,089,880
JBrowse link
G Bcl2l1 BCL2-like 1 multiple interactions
increases expression
ISO [Paraquat co-treated with Maneb] results in decreased expression of BCL2L1 protein
Maneb results in increased expression of BCL2L1 mRNA
CTD PMID:15824117 PMID:18266926 NCBI chr 2:152,600,652...152,675,723
Ensembl chr 2:152,622,588...152,673,648
JBrowse link
G Bcl2l11 BCL2-like 11 (apoptosis facilitator) multiple interactions
increases expression
ISO [Paraquat co-treated with Maneb] results in increased expression of BCL2L11 protein
Maneb results in increased expression of BCL2L11 protein
CTD PMID:18266926 NCBI chr 2:127,967,958...128,004,467
Ensembl chr 2:127,967,958...128,004,467
JBrowse link
G Bdnf brain derived neurotrophic factor multiple interactions EXP
ISO
[Maneb co-treated with Paraquat] results in decreased expression of BDNF mRNA
[Paraquat co-treated with Maneb] results in decreased expression of BDNF mRNA; [Paraquat co-treated with Maneb] results in decreased expression of BDNF protein; Taurine inhibits the reaction [[Paraquat co-treated with Maneb] results in decreased expression of BDNF mRNA]; Taurine inhibits the reaction [[Paraquat co-treated with Maneb] results in decreased expression of BDNF protein]
CTD PMID:23017109 PMID:27460631 PMID:33368748 NCBI chr 2:109,505,045...109,557,388
Ensembl chr 2:109,505,045...109,557,352
JBrowse link
G Becn1 beclin 1, autophagy related increases expression
multiple interactions
EXP Maneb results in increased expression of BECN1 protein
[Paraquat co-treated with Maneb] results in increased expression of BECN1 protein
CTD PMID:22292029 PMID:26884967 NCBI chr11:101,179,084...101,193,112
Ensembl chr11:101,176,778...101,193,112
JBrowse link
G Bicd1 BICD cargo adaptor 1 multiple interactions EXP [Paraquat co-treated with Maneb] affects the expression of BICD1 mRNA CTD PMID:22563483 NCBI chr 6:149,310,322...149,464,827
Ensembl chr 6:149,310,384...149,464,827
JBrowse link
G Bid BH3 interacting domain death agonist multiple interactions
increases expression
ISO [Maneb co-treated with Paraquat] results in increased expression of BID protein
Maneb results in increased expression of BID protein
CTD PMID:18266926 NCBI chr 6:120,870,080...120,894,074
Ensembl chr 6:120,868,891...120,893,814
JBrowse link
G Bik BCL2-interacting killer increases expression
multiple interactions
ISO Maneb results in increased expression of BIK mRNA; Maneb results in increased expression of BIK protein
[Paraquat co-treated with Maneb] results in increased expression of BIK protein
CTD PMID:18266926 NCBI chr15:83,410,992...83,428,836
Ensembl chr15:83,411,063...83,428,835
JBrowse link
G Bmp2 bone morphogenetic protein 2 multiple interactions EXP [SNCA protein co-treated with Maneb co-treated with Paraquat] results in decreased expression of BMP2 mRNA CTD PMID:23017109 NCBI chr 2:133,394,079...133,404,816
Ensembl chr 2:133,394,079...133,404,805
JBrowse link
G Bmp4 bone morphogenetic protein 4 multiple interactions EXP [LRRK2 protein mutant form co-treated with Maneb co-treated with Paraquat] results in decreased expression of BMP4 mRNA; [SNCA protein co-treated with Maneb co-treated with Paraquat] results in decreased expression of BMP4 mRNA CTD PMID:23017109 NCBI chr14:46,620,982...46,628,126
Ensembl chr14:46,620,977...46,628,126
JBrowse link
G Bnip3 BCL2/adenovirus E1B interacting protein 3 increases expression ISO Maneb results in increased expression of BNIP3 mRNA; Maneb results in increased expression of BNIP3 protein CTD PMID:18266926 NCBI chr 7:138,492,565...138,511,235
Ensembl chr 7:138,492,565...138,511,248
JBrowse link
G Bnip3l BCL2/adenovirus E1B interacting protein 3-like increases expression ISO Maneb results in increased expression of BNIP3L mRNA CTD PMID:18266926 NCBI chr14:67,222,688...67,246,580
Ensembl chr14:67,222,688...67,246,326
JBrowse link
G Brf1 BRF1, RNA polymerase III transcription initiation factor 90 kDa subunit multiple interactions EXP [Paraquat co-treated with Maneb] results in increased expression of BRF1 mRNA CTD PMID:18386188 NCBI chr12:112,919,251...112,964,327
Ensembl chr12:112,923,705...112,964,324
JBrowse link
G Cacna1e calcium channel, voltage-dependent, R type, alpha 1E subunit multiple interactions EXP [Paraquat co-treated with Maneb] affects the expression of CACNA1E mRNA CTD PMID:22563483 NCBI chr 1:154,266,552...154,760,374
Ensembl chr 1:154,266,477...154,760,247
JBrowse link
G Cacybp calcyclin binding protein multiple interactions EXP [Paraquat co-treated with Maneb] results in increased expression of CACYBP mRNA CTD PMID:18386188 NCBI chr 1:160,029,937...160,040,462
Ensembl chr 1:160,029,937...160,040,445
JBrowse link
G Calm1 calmodulin 1 multiple interactions EXP [Maneb co-treated with Paraquat] results in increased expression of CALM1 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of CALM1 mRNA]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of CALM1 mRNA] CTD PMID:23963992 NCBI chr12:100,165,694...100,176,083
Ensembl chr12:100,165,694...100,176,073
JBrowse link
G Calm2 calmodulin 2 multiple interactions EXP [Paraquat co-treated with Maneb] results in increased expression of CALM2 mRNA CTD PMID:18386188 NCBI chr17:87,740,829...87,754,363
Ensembl chr17:87,740,840...87,754,363
JBrowse link
G Camp cathelicidin antimicrobial peptide multiple interactions EXP
ISO
[Paraquat co-treated with Maneb] affects the expression of CAMP mRNA
[Paraquat co-treated with Maneb] results in decreased expression of CAMP mRNA
CTD PMID:22563483 PMID:27460631 NCBI chr 9:109,676,445...109,678,524
Ensembl chr 9:109,676,447...109,678,685
JBrowse link
G Capn11 calpain 11 multiple interactions EXP [Paraquat co-treated with Maneb] affects the expression of CAPN11 mRNA CTD PMID:22563483 NCBI chr17:45,941,117...45,970,400
Ensembl chr17:45,941,130...45,970,251
JBrowse link
G Casp1 caspase 1 multiple interactions EXP [Maneb co-treated with Paraquat] results in increased cleavage of CASP1 protein; [Maneb co-treated with Paraquat] results in increased expression of CASP1 mRNA; [Paraquat co-treated with Maneb] results in increased cleavage of CASP1 protein; Glyburide inhibits the reaction [[Maneb co-treated with Paraquat] results in increased cleavage of CASP1 protein]; Glyburide inhibits the reaction [[Paraquat co-treated with Maneb] results in increased cleavage of CASP1 protein]; ITGAM protein affects the reaction [[Paraquat co-treated with Maneb] results in increased cleavage of CASP1 protein]; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of CASP1 mRNA]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of CASP1 mRNA] CTD PMID:23963992 PMID:32375810 PMID:34052309 NCBI chr 9:5,298,517...5,307,281
Ensembl chr 9:5,298,508...5,307,290
JBrowse link
G Casp3 caspase 3 increases activity ISO Maneb results in increased activity of CASP3 protein CTD PMID:22824503 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724
JBrowse link
G Casp7 caspase 7 increases activity ISO Maneb results in increased activity of CASP7 protein CTD PMID:22824503 NCBI chr19:56,382,640...56,430,780
Ensembl chr19:56,385,561...56,430,776
JBrowse link
G Casp8 caspase 8 increases activity ISO Maneb results in increased activity of CASP8 protein CTD PMID:22824503 NCBI chr 1:58,834,398...58,886,662
Ensembl chr 1:58,834,533...58,886,662
JBrowse link
G Casp9 caspase 9 multiple interactions
increases activity
EXP
ISO
[Maneb co-treated with Paraquat] results in increased expression of CASP9 mRNA; [Paraquat co-treated with Maneb] results in increased expression of CASP9 protein; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of CASP9 mRNA]; Melatonin inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of CASP9 protein]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of CASP9 mRNA]; Silymarin inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of CASP9 protein]
Maneb results in increased activity of CASP9 protein
CTD PMID:20964710 PMID:22824503 PMID:23963992 NCBI chr 4:141,520,923...141,543,289
Ensembl chr 4:141,520,923...141,543,287
JBrowse link
G Cat catalase decreases activity
multiple interactions
EXP
ISO
Maneb results in decreased activity of CAT protein
[Maneb co-treated with Paraquat] results in increased expression of CAT mRNA
CTD PMID:26210702 PMID:29859004 NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505
JBrowse link
G Ccdc88a coiled coil domain containing 88A multiple interactions EXP [Paraquat co-treated with Maneb] affects the expression of CCDC88A mRNA CTD PMID:22563483 NCBI chr11:29,323,521...29,460,808
Ensembl chr11:29,323,658...29,460,808
JBrowse link
G Ccl19 chemokine (C-C motif) ligand 19 multiple interactions EXP [Paraquat co-treated with Maneb] affects the expression of CCL19 mRNA CTD PMID:22563483 NCBI chr 4:42,754,525...42,756,365
Ensembl chr 4:42,754,525...42,756,577
JBrowse link
G Ccl21a chemokine (C-C motif) ligand 21A (serine) multiple interactions EXP [Paraquat co-treated with Maneb] affects the expression of CCL21 mRNA; [Paraquat co-treated with Maneb] affects the expression of CCL21A mRNA CTD PMID:22563483 NCBI chr 4:42,772,860...42,773,991
Ensembl chr 4:42,772,860...42,773,993
JBrowse link
G Ccl21d chemokine (C-C motif) ligand 21D multiple interactions EXP [Paraquat co-treated with Maneb] affects the expression of CCL21D mRNA CTD PMID:22563483 NCBI chr 4:41,896,187...41,904,743
Ensembl chr 4:41,903,610...41,904,743
JBrowse link
G Ccnd1 cyclin D1 multiple interactions EXP
ISO
[alachlor co-treated with Captan co-treated with Diazinon co-treated with Endosulfan co-treated with mancozeb co-treated with Maneb] results in increased expression of CCND1 protein
[Maneb co-treated with Paraquat] results in decreased expression of CCND1 mRNA
CTD PMID:19883720 PMID:29859004 NCBI chr 7:144,483,668...144,493,568
Ensembl chr 7:144,483,668...144,493,662
JBrowse link
G Ccnd2 cyclin D2 multiple interactions ISO [Maneb co-treated with Paraquat] results in decreased expression of CCND2 mRNA CTD PMID:29859004 NCBI chr 6:127,102,125...127,131,913
Ensembl chr 6:127,102,125...127,129,156
JBrowse link
G Cd34 CD34 antigen increases expression ISO Maneb results in increased expression of CD34 CTD PMID:25803990 NCBI chr 1:194,621,129...194,643,600
Ensembl chr 1:194,621,127...194,643,587
JBrowse link
G Cd68 CD68 antigen multiple interactions EXP [Paraquat co-treated with Maneb] results in increased expression of CD68 mRNA; Poloxamer inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of CD68 mRNA] CTD PMID:32169474 NCBI chr11:69,555,039...69,556,996
Ensembl chr11:69,555,039...69,556,979
JBrowse link
G Cdhr4 cadherin-related family member 4 multiple interactions EXP [Paraquat co-treated with Maneb] affects the expression of CDHR4 mRNA CTD PMID:22563483 NCBI chr 9:107,869,656...107,876,880
Ensembl chr 9:107,869,696...107,876,883
JBrowse link
G Cdipt CDP-diacylglycerol--inositol 3-phosphatidyltransferase (phosphatidylinositol synthase) multiple interactions EXP [Paraquat co-treated with Maneb] results in decreased expression of CDIPT mRNA CTD PMID:18386188 NCBI chr 7:126,575,630...126,579,671
Ensembl chr 7:126,575,086...126,579,673
JBrowse link
G Cdk2 cyclin-dependent kinase 2 multiple interactions EXP [Maneb co-treated with Paraquat] results in decreased expression of CDK2 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of CDK2 mRNA]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of CDK2 mRNA] CTD PMID:23963992 NCBI chr10:128,533,807...128,540,920
Ensembl chr10:128,533,808...128,540,900
JBrowse link
G Cdk5r1 cyclin-dependent kinase 5, regulatory subunit 1 (p35) multiple interactions EXP [LRRK2 protein mutant form co-treated with Maneb co-treated with Paraquat] results in decreased expression of CDK5R1 mRNA CTD PMID:23017109 NCBI chr11:80,367,849...80,372,010
Ensembl chr11:80,367,849...80,372,010
JBrowse link
G Cdk5rap1 CDK5 regulatory subunit associated protein 1 multiple interactions EXP [LRRK2 protein mutant form co-treated with Maneb co-treated with Paraquat] results in decreased expression of CDK5RAP1 mRNA CTD PMID:23017109 NCBI chr 2:154,063,931...154,216,170
Ensembl chr 2:154,177,300...154,214,930
JBrowse link
G Cdk5rap2 CDK5 regulatory subunit associated protein 2 multiple interactions EXP [Maneb co-treated with Paraquat] results in increased expression of CDK5RAP2 mRNA; LRRK2 protein mutant form inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of CDK5RAP2 mRNA]; SNCA protein inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of CDK5RAP2 mRNA] CTD PMID:23017109 NCBI chr 4:70,135,092...70,328,672
Ensembl chr 4:70,135,093...70,328,680
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A (P21) multiple interactions EXP [Maneb co-treated with Paraquat] results in increased expression of CDKN1A mRNA; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of CDKN1A mRNA] CTD PMID:23963992 NCBI chr17:29,309,953...29,319,696
Ensembl chr17:29,309,950...29,319,701
JBrowse link
G Cdkn2a cyclin dependent kinase inhibitor 2A multiple interactions
increases expression
ISO [Maneb co-treated with Paraquat] results in increased expression of CDKN2A mRNA
Maneb results in increased expression of CDKN2A mRNA
CTD PMID:29859004 NCBI chr 4:89,192,710...89,212,856
Ensembl chr 4:89,192,708...89,212,890
JBrowse link
G Cebpd CCAAT/enhancer binding protein (C/EBP), delta multiple interactions EXP [Paraquat co-treated with Maneb] affects the expression of CEBPD mRNA CTD PMID:22563483 NCBI chr16:15,705,150...15,707,409
Ensembl chr16:15,705,150...15,708,895
JBrowse link
G Cep290 centrosomal protein 290 multiple interactions EXP [Paraquat co-treated with Maneb] affects the expression of CEP290 mRNA CTD PMID:22563483 NCBI chr10:100,323,410...100,411,533
Ensembl chr10:100,323,420...100,410,702
JBrowse link
G Chil3 chitinase-like 3 multiple interactions EXP [Paraquat co-treated with Maneb] results in increased expression of CHIL3 mRNA CTD PMID:29568078 PMID:32375810 NCBI chr 3:106,054,870...106,074,880
Ensembl chr 3:106,054,870...106,074,880
JBrowse link
G Chrm2 cholinergic receptor, muscarinic 2, cardiac multiple interactions EXP [LRRK2 protein mutant form co-treated with Maneb co-treated with Paraquat] results in decreased expression of CHRM2 mRNA CTD PMID:23017109 NCBI chr 6:36,364,928...36,505,573
Ensembl chr 6:36,365,019...36,505,349
JBrowse link
G Chuk conserved helix-loop-helix ubiquitous kinase multiple interactions EXP [Paraquat co-treated with Maneb] results in increased phosphorylation of CHUK protein; Taurine inhibits the reaction [[Paraquat co-treated with Maneb] results in increased phosphorylation of CHUK protein] CTD PMID:29568078 NCBI chr19:44,061,773...44,095,940
Ensembl chr19:44,061,774...44,095,919
JBrowse link
G Cirbp cold inducible RNA binding protein multiple interactions EXP [Paraquat co-treated with Maneb] results in decreased expression of CIRBP mRNA CTD PMID:18386188 NCBI chr10:80,001,824...80,008,620
Ensembl chr10:80,001,819...80,008,620
JBrowse link
G Clca1 chloride channel accessory 1 multiple interactions EXP [Maneb co-treated with Paraquat] results in decreased expression of CLCA1 mRNA; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of CLCA1 mRNA] CTD PMID:23963992 NCBI chr 3:144,710,298...144,738,537
Ensembl chr 3:144,709,578...144,738,537
JBrowse link
G Clu clusterin multiple interactions EXP [Paraquat co-treated with Maneb] results in decreased expression of CLU mRNA CTD PMID:18386188 NCBI chr14:66,205,932...66,218,997
Ensembl chr14:66,205,932...66,218,996
JBrowse link
G Cope coatomer protein complex, subunit epsilon multiple interactions EXP [Paraquat co-treated with Maneb] results in decreased expression of COPE mRNA CTD PMID:18386188 NCBI chr 8:70,755,417...70,765,652
Ensembl chr 8:70,755,168...70,765,643
JBrowse link
G Cox5a cytochrome c oxidase subunit 5A multiple interactions EXP [Maneb co-treated with Paraquat] results in decreased expression of COX5A protein; Levodopa inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of COX5A protein]; Minocycline inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of COX5A protein]; tetrakis(N-methyl-4-pyridiniumyl)porphine manganese(III) complex inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of COX5A protein] CTD PMID:23562983 NCBI chr 9:57,423,012...57,439,710
Ensembl chr 9:57,428,557...57,439,709
JBrowse link
G Cox6a1 cytochrome c oxidase subunit 6A1 multiple interactions EXP [Paraquat co-treated with Maneb] results in decreased expression of COX6A1 mRNA CTD PMID:18386188 NCBI chr 5:115,483,711...115,487,017
Ensembl chr 5:115,483,701...115,487,040
JBrowse link
G Cox6b1 cytochrome c oxidase, subunit 6B1 multiple interactions EXP [Maneb co-treated with Paraquat] results in decreased expression of COX6B1 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of COX6B1 mRNA]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of COX6B1 mRNA] CTD PMID:23963992 NCBI chr 7:30,316,396...30,325,539
Ensembl chr 7:30,316,286...30,325,576
JBrowse link
G Cox7a2 cytochrome c oxidase subunit 7A2 multiple interactions EXP [Paraquat co-treated with Maneb] results in decreased expression of COX7A2 mRNA CTD PMID:18386188 NCBI chr 9:79,662,523...79,667,135
Ensembl chr 9:79,662,643...79,667,160
JBrowse link
G Cox7a2l cytochrome c oxidase subunit 7A2 like multiple interactions EXP [Paraquat co-treated with Maneb] results in decreased expression of COX7A2L mRNA CTD PMID:18386188 NCBI chr17:83,809,346...83,821,762
Ensembl chr17:83,809,347...83,824,759
JBrowse link
G Cplx1 complexin 1 multiple interactions EXP [Paraquat co-treated with Maneb] results in decreased expression of CPLX1 mRNA; [Paraquat co-treated with Maneb] results in decreased expression of CPLX1 protein CTD PMID:17532186 NCBI chr 5:108,666,420...108,697,893
Ensembl chr 5:108,666,420...108,697,890
JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions EXP
ISO
[Maneb co-treated with Paraquat] results in decreased expression of CREB1 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of CREB1 mRNA]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of CREB1 mRNA]
[Paraquat co-treated with Maneb] results in decreased expression of and results in decreased phosphorylation of CREB1 protein; [Paraquat co-treated with Maneb] results in decreased expression of CREB1 mRNA; [Paraquat co-treated with Maneb] results in decreased expression of CREB1 protein; [Paraquat co-treated with Maneb] results in decreased expression of CREB1 protein modified form; Taurine inhibits the reaction [[Paraquat co-treated with Maneb] results in decreased expression of and results in decreased phosphorylation of CREB1 protein]; Taurine inhibits the reaction [[Paraquat co-treated with Maneb] results in decreased expression of CREB1 mRNA]
CTD PMID:23963992 PMID:27460631 PMID:33368748 NCBI chr 1:64,571,963...64,643,707
Ensembl chr 1:64,571,804...64,643,707
JBrowse link
G Crip2 cysteine rich protein 2 multiple interactions EXP [Paraquat co-treated with Maneb] results in decreased expression of CRIP2 mRNA CTD PMID:18386188 NCBI chr12:113,103,856...113,109,126
Ensembl chr12:113,103,856...113,109,126
JBrowse link
G Crlf2 cytokine receptor-like factor 2 multiple interactions EXP [Paraquat co-treated with Maneb] affects the expression of CRLF2 mRNA CTD PMID:22563483 NCBI chr 5:109,702,575...109,707,301
Ensembl chr 5:109,702,575...109,706,859
JBrowse link
G Crot carnitine O-octanoyltransferase multiple interactions EXP [Paraquat co-treated with Maneb] results in decreased expression of CROT mRNA CTD PMID:18386188 NCBI chr 5:9,016,033...9,047,926
Ensembl chr 5:9,016,033...9,047,324
JBrowse link
G Csf1r colony stimulating factor 1 receptor multiple interactions EXP [Paraquat co-treated with Maneb] results in increased expression of CSF1R mRNA; Poloxamer inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of CSF1R mRNA] CTD PMID:32169474 NCBI chr18:61,238,644...61,264,211
Ensembl chr18:61,233,670...61,265,221
JBrowse link
G Csf2ra colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage) multiple interactions EXP [Paraquat co-treated with Maneb] results in increased expression of CSF2RA mRNA; Poloxamer inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of CSF2RA mRNA] CTD PMID:32169474 NCBI chr19:61,205,629...61,221,141
Ensembl chr19:61,212,395...61,216,867
JBrowse link
G Ctsl cathepsin L multiple interactions EXP [Maneb co-treated with Paraquat] results in increased expression of CTSL mRNA; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of CTSL mRNA] CTD PMID:23963992 NCBI chr13:64,509,704...64,518,586
Ensembl chr13:64,507,151...64,518,704
JBrowse link
G Cybb cytochrome b-245, beta polypeptide multiple interactions ISO
EXP
[Paraquat co-treated with Maneb] results in increased expression of CYBB mRNA; acetovanillone inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of CYBB mRNA]; diphenyleneiodonium inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of CYBB mRNA]
[Maneb co-treated with Paraquat] results in increased expression of CYBB protein; [Paraquat co-treated with Maneb] results in increased expression of CYBB protein; Glyburide inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of CYBB protein]; Glyburide inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of CYBB protein]; Taurine inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of CYBB protein]
CTD PMID:29568078 PMID:30797899 PMID:32375810 PMID:34052309 NCBI chr  X:9,301,493...9,354,005
Ensembl chr  X:9,301,491...9,354,010
JBrowse link
G Cyc1 cytochrome c-1 multiple interactions EXP [Paraquat co-treated with Maneb] results in decreased expression of CYC1 mRNA CTD PMID:18386188 NCBI chr15:76,227,711...76,230,460
Ensembl chr15:76,227,723...76,230,460
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases activity
decreases expression
increases expression
ISO Maneb results in increased activity of CYP1A1 protein
Maneb results in decreased expression of CYP1A1 mRNA
Maneb results in increased expression of CYP1A1 mRNA; Maneb results in increased expression of CYP1A1 protein
CTD PMID:20888808 PMID:32194361 NCBI chr 9:57,595,211...57,611,107
Ensembl chr 9:57,595,211...57,611,107
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions ISO [Paraquat co-treated with Maneb] results in increased expression of and results in increased activity of CYP1A2 protein; [Paraquat co-treated with Maneb] results in increased expression of CYP1A2 mRNA; Acetylcysteine inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of and results in increased activity of CYP1A2 protein]; Acetylcysteine inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of CYP1A2 mRNA]; Silymarin inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of and results in increased activity of CYP1A2 protein]; Silymarin inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of CYP1A2 mRNA] CTD PMID:23159886 NCBI chr 9:57,584,220...57,590,938
Ensembl chr 9:57,584,220...57,590,986
JBrowse link
G Cyp2c38 cytochrome P450, family 2, subfamily c, polypeptide 38 decreases expression ISO Maneb results in decreased expression of CYP2C19 protein CTD PMID:32194361 NCBI chr19:39,378,000...39,451,547
Ensembl chr19:39,378,000...39,451,519
JBrowse link
G Cyp2d22 cytochrome P450, family 2, subfamily d, polypeptide 22 multiple interactions
decreases expression
EXP Ketoconazole inhibits the reaction [Maneb results in decreased expression of CYP2D22 protein] CTD PMID:22334051 NCBI chr15:82,254,728...82,264,461
Ensembl chr15:82,254,728...82,264,461
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 decreases activity
increases expression
multiple interactions
increases activity
ISO
EXP
Maneb results in decreased activity of CYP2E1 protein
Maneb results in increased expression of CYP2E1 mRNA; Maneb results in increased expression of CYP2E1 protein
[Maneb co-treated with Paraquat] results in increased expression of and results in increased activity of CYP2E1 protein; [Maneb co-treated with Paraquat] results in increased expression of CYP2E1 mRNA; Acetylcysteine inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of and results in increased activity of CYP2E1 protein]; Acetylcysteine inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of CYP2E1 mRNA]; Acetylcysteine inhibits the reaction [Maneb results in increased expression of and results in increased activity of CYP2E1 protein]; Acetylcysteine inhibits the reaction [Maneb results in increased expression of CYP2E1 mRNA]; Maneb results in increased expression of and results in increased activity of CYP2E1 protein; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of and results in increased activity of CYP2E1 protein]; Silymarin inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of CYP2E1 mRNA]; Silymarin inhibits the reaction [Maneb results in increased expression of and results in increased activity of CYP2E1 protein]; Silymarin inhibits the reaction [Maneb results in increased expression of CYP2E1 mRNA]
Maneb results in increased activity of CYP2E1 protein
[Maneb co-treated with Paraquat] results in increased expression of CYP2E1 mRNA; [Paraquat co-treated with Maneb] results in increased activity of CYP2E1 protein; [Paraquat co-treated with Maneb] results in increased expression of CYP2E1 mRNA; Melatonin inhibits the reaction [[Paraquat co-treated with Maneb] results in increased activity of CYP2E1 protein]; Melatonin inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of CYP2E1 mRNA]; Silymarin inhibits the reaction [[Paraquat co-treated with Maneb] results in increased activity of CYP2E1 protein]; Silymarin inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of CYP2E1 mRNA]
CTD PMID:11043497 PMID:16510128 PMID:20888808 PMID:20964710 PMID:23159886 NCBI chr 7:140,343,732...140,354,903
Ensembl chr 7:140,343,652...140,354,900
JBrowse link
G Cyp7a1 cytochrome P450, family 7, subfamily a, polypeptide 1 decreases expression ISO Maneb results in decreased expression of CYP7A1 mRNA CTD PMID:32194361 NCBI chr 4:6,265,612...6,275,632
Ensembl chr 4:6,265,612...6,275,633
JBrowse link
G Dap3 death associated protein 3 multiple interactions EXP [Maneb co-treated with Paraquat] results in increased expression of DAP3 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of DAP3 mRNA] CTD PMID:23963992 NCBI chr 3:88,828,110...88,858,504
Ensembl chr 3:88,828,110...88,858,488
JBrowse link
G Dbi diazepam binding inhibitor multiple interactions EXP [Paraquat co-treated with Maneb] results in decreased expression of DBI mRNA CTD PMID:18386188 NCBI chr 1:120,041,010...120,048,826
Ensembl chr 1:120,041,010...120,048,808
JBrowse link
G Ddit4 DNA-damage-inducible transcript 4 increases expression ISO Maneb results in increased expression of DDIT4 protein CTD PMID:24764117 NCBI chr10:59,785,497...59,787,592
Ensembl chr10:59,785,491...59,787,656
JBrowse link
G Ddx5 DEAD box helicase 5 multiple interactions EXP [Paraquat co-treated with Maneb] results in increased expression of DDX5 mRNA CTD PMID:18386188 NCBI chr11:106,671,181...106,680,011
Ensembl chr11:106,671,181...106,680,011
JBrowse link
G Dgki diacylglycerol kinase, iota multiple interactions EXP [Paraquat co-treated with Maneb] affects the expression of DGKI mRNA CTD PMID:22563483 NCBI chr 6:36,814,316...37,281,034
Ensembl chr 6:36,822,957...37,277,119
JBrowse link
G Dio1 deiodinase, iodothyronine, type I decreases activity ISO Maneb results in decreased activity of DIO1 protein CTD PMID:29228274 NCBI chr 4:107,148,662...107,164,365
Ensembl chr 4:107,148,662...107,164,366
JBrowse link
G Dip2b disco interacting protein 2 homolog B multiple interactions EXP [Paraquat co-treated with Maneb] affects the expression of DIP2B mRNA CTD PMID:22563483 NCBI chr15:99,935,119...100,117,355
Ensembl chr15:99,936,545...100,117,354
JBrowse link
G Dll1 delta like canonical Notch ligand 1 multiple interactions EXP [SNCA protein co-treated with Maneb co-treated with Paraquat] results in decreased expression of DLL1 mRNA CTD PMID:23017109 NCBI chr17:15,587,616...15,597,275
Ensembl chr17:15,587,616...15,597,134
JBrowse link
G Dlst dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex) multiple interactions EXP [Maneb co-treated with Paraquat] results in increased expression of DLST protein; Minocycline inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of DLST protein]; tetrakis(N-methyl-4-pyridiniumyl)porphine manganese(III) complex inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of DLST protein] CTD PMID:23562983 NCBI chr12:85,157,597...85,180,865
Ensembl chr12:85,157,607...85,181,619
JBrowse link
G Dmrta2 doublesex and mab-3 related transcription factor like family A2 multiple interactions EXP [Paraquat co-treated with Maneb] affects the expression of DMRTA2 mRNA CTD PMID:22563483 NCBI chr 4:109,835,222...109,840,896
Ensembl chr 4:109,835,250...109,840,884
JBrowse link
G Dnajb6 DnaJ heat shock protein family (Hsp40) member B6 multiple interactions EXP [Paraquat co-treated with Maneb] results in increased expression of DNAJB6 mRNA CTD PMID:18386188 NCBI chr 5:29,940,896...29,991,476
Ensembl chr 5:29,940,686...30,023,132
JBrowse link
G Dnm2 dynamin 2 multiple interactions EXP [Maneb co-treated with Paraquat] results in decreased expression of DNM2 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of DNM2 mRNA] CTD PMID:23963992 NCBI chr 9:21,336,167...21,419,055
Ensembl chr 9:21,336,204...21,419,055
JBrowse link
G Drd2 dopamine receptor D2 multiple interactions EXP [SNCA protein co-treated with Maneb co-treated with Paraquat] results in decreased expression of DRD2 mRNA CTD PMID:23017109 NCBI chr 9:49,251,633...49,319,477
Ensembl chr 9:49,251,927...49,319,477
JBrowse link
G Drd4 dopamine receptor D4 multiple interactions EXP [Paraquat co-treated with Maneb] results in increased expression of DRD4 protein CTD PMID:22563483 NCBI chr 7:140,871,887...140,876,377
Ensembl chr 7:140,871,919...140,876,377
JBrowse link
G Drd5 dopamine receptor D5 multiple interactions EXP [SNCA protein co-treated with Maneb co-treated with Paraquat] results in decreased expression of DRD5 mRNA CTD PMID:23017109 NCBI chr 5:38,476,852...38,479,866
Ensembl chr 5:38,476,710...38,479,861
JBrowse link
G E2f1 E2F transcription factor 1 multiple interactions EXP [Maneb co-treated with Paraquat] results in increased expression of E2F1 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of E2F1 mRNA] CTD PMID:23963992 NCBI chr 2:154,401,320...154,411,812
Ensembl chr 2:154,401,327...154,411,812
JBrowse link
G Eef1a1 eukaryotic translation elongation factor 1 alpha 1 multiple interactions EXP [Paraquat co-treated with Maneb] results in increased expression of EEF1A1 mRNA CTD PMID:18386188 NCBI chr 9:78,385,735...78,389,006
Ensembl chr 9:78,385,731...78,396,433
JBrowse link
G Eef1g eukaryotic translation elongation factor 1 gamma multiple interactions EXP [Maneb co-treated with Paraquat] results in decreased expression of EEF1G mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of EEF1G mRNA]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of EEF1G mRNA] CTD PMID:23963992 NCBI chr19:8,944,405...8,955,544
Ensembl chr19:8,944,405...8,955,843
JBrowse link
G Efnb1 ephrin B1 multiple interactions EXP [LRRK2 protein mutant form co-treated with Maneb co-treated with Paraquat] results in decreased expression of EFNB1 mRNA CTD PMID:23017109 NCBI chr  X:98,179,667...98,192,628
Ensembl chr  X:98,179,736...98,192,597
JBrowse link
G Egr4 early growth response 4 multiple interactions EXP [Paraquat co-treated with Maneb] affects the expression of EGR4 mRNA CTD PMID:22563483 NCBI chr 6:85,488,103...85,490,571
Ensembl chr 6:85,488,103...85,490,571
JBrowse link
G Eif4g2 eukaryotic translation initiation factor 4, gamma 2 multiple interactions EXP [Maneb co-treated with Paraquat] results in decreased expression of EIF4G2 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of EIF4G2 mRNA] CTD PMID:23963992 NCBI chr 7:110,667,192...110,682,237
Ensembl chr 7:110,666,957...110,682,237
JBrowse link
G Elk1 ELK1, member of ETS oncogene family multiple interactions EXP [Maneb co-treated with Paraquat] results in decreased expression of ELK1 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of ELK1 mRNA] CTD PMID:23963992 NCBI chr  X:20,799,634...20,816,847
Ensembl chr  X:20,799,634...20,816,847
JBrowse link
G Eno1 enolase 1, alpha non-neuron multiple interactions EXP [Maneb co-treated with Paraquat] results in increased expression of ENO1 protein; [Paraquat co-treated with Maneb] results in decreased expression of ENO1 mRNA; [Paraquat co-treated with Maneb] results in decreased expression of ENO1 protein; Minocycline inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of ENO1 protein] CTD PMID:17532186 PMID:18386188 PMID:23562983 NCBI chr 4:150,321,165...150,333,336
Ensembl chr 4:150,321,178...150,333,336
JBrowse link
G Eno2 enolase 2, gamma neuronal multiple interactions EXP [Maneb co-treated with Paraquat] results in increased expression of ENO2 protein CTD PMID:23562983 NCBI chr 6:124,737,016...124,746,636
Ensembl chr 6:124,737,016...124,746,636
JBrowse link
G Etl4 enhancer trap locus 4 multiple interactions EXP [Paraquat co-treated with Maneb] affects the expression of ETL4 mRNA CTD PMID:22563483 NCBI chr 2:19,915,018...20,815,346
Ensembl chr 2:19,914,591...20,815,524
JBrowse link
G Fas Fas (TNF receptor superfamily member 6) multiple interactions EXP [Maneb co-treated with Paraquat] results in increased expression of FAS mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of FAS mRNA]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of FAS mRNA] CTD PMID:23963992 NCBI chr19:34,267,926...34,305,175
Ensembl chr19:34,268,066...34,305,172
JBrowse link
G Fez1 fasciculation and elongation protein zeta 1 (zygin I) multiple interactions EXP [LRRK2 protein mutant form co-treated with Maneb co-treated with Paraquat] results in decreased expression of FEZ1 mRNA CTD PMID:23017109 NCBI chr 9:36,732,694...36,790,222
Ensembl chr 9:36,733,160...36,790,220
JBrowse link
G Fgfr3 fibroblast growth factor receptor 3 multiple interactions EXP [Maneb co-treated with Paraquat] results in increased expression of FGFR3 mRNA; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of FGFR3 mRNA] CTD PMID:23963992 NCBI chr 5:33,879,068...33,894,412
Ensembl chr 5:33,879,018...33,894,412
JBrowse link
G Fkbp4 FK506 binding protein 4 multiple interactions EXP [Paraquat co-treated with Maneb] results in decreased expression of FKBP4 mRNA CTD PMID:18386188 NCBI chr 6:128,407,066...128,415,619
Ensembl chr 6:128,406,698...128,415,640
JBrowse link
G Fkbp5 FK506 binding protein 5 multiple interactions EXP [Paraquat co-treated with Maneb] results in decreased expression of FKBP5 mRNA CTD PMID:18386188 NCBI chr17:28,617,727...28,705,123
Ensembl chr17:28,618,068...28,736,501
JBrowse link
G Fos FBJ osteosarcoma oncogene multiple interactions EXP
ISO
[Maneb co-treated with Paraquat] results in increased expression of FOS mRNA; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of FOS mRNA]
[Paraquat co-treated with Maneb] results in decreased expression of FOS mRNA; [Paraquat co-treated with Maneb] results in decreased expression of FOS protein; Taurine inhibits the reaction [[Paraquat co-treated with Maneb] results in decreased expression of FOS mRNA]; Taurine inhibits the reaction [[Paraquat co-treated with Maneb] results in decreased expression of FOS protein]
CTD PMID:23963992 PMID:27460631 PMID:33368748 NCBI chr12:85,520,664...85,524,048
Ensembl chr12:85,520,664...85,524,047
JBrowse link
G Fxyd6 FXYD domain-containing ion transport regulator 6 multiple interactions EXP [Paraquat co-treated with Maneb] results in decreased expression of FXYD6 mRNA CTD PMID:18386188 NCBI chr 9:45,280,768...45,307,457
Ensembl chr 9:45,281,483...45,307,457
JBrowse link
G G6pc glucose-6-phosphatase, catalytic decreases expression ISO Maneb results in decreased expression of G6PC1 mRNA CTD PMID:32194361 NCBI chr11:101,258,542...101,268,729
Ensembl chr11:101,258,387...101,268,729
JBrowse link
G Gabra6 gamma-aminobutyric acid (GABA) A receptor, subunit alpha 6 multiple interactions EXP [Paraquat co-treated with Maneb] affects the expression of GABRA6 mRNA CTD PMID:22563483 NCBI chr11:42,197,264...42,211,977
Ensembl chr11:42,197,264...42,211,899
JBrowse link
G Gas5 growth arrest specific 5 multiple interactions EXP [Paraquat co-treated with Maneb] results in decreased expression of GAS5 mRNA CTD PMID:18386188 NCBI chr 1:160,862,171...160,866,109
Ensembl chr 1:160,861,992...160,866,109
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression
increases activity
ISO [Maneb results in increased expression of NFE2L2 protein] which results in increased expression of GCLC mRNA
Maneb results in increased activity of GCLC protein
CTD PMID:15527874 PMID:21402726 NCBI chr 9:77,661,817...77,701,771
Ensembl chr 9:77,661,817...77,701,767
JBrowse link
G Gfap glial fibrillary acidic protein multiple interactions EXP [Paraquat co-treated with Maneb] results in increased expression of GFAP protein; acetovanillone inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of GFAP protein] CTD PMID:30797899 NCBI chr11:102,778,162...102,791,368
Ensembl chr11:102,778,162...102,791,738
JBrowse link
G Gh growth hormone multiple interactions EXP [Paraquat co-treated with Maneb] affects the expression of GH mRNA CTD PMID:22563483 NCBI chr11:106,191,087...106,194,529
Ensembl chr11:106,191,097...106,192,691
JBrowse link
G Gm2a GM2 ganglioside activator protein multiple interactions EXP [Paraquat co-treated with Maneb] results in decreased expression of GM2A mRNA CTD PMID:18386188 NCBI chr11:54,988,811...55,003,855
Ensembl chr11:54,988,941...55,003,855
JBrowse link
G Gm40318 predicted gene, 40318 increases expression ISO Maneb results in increased expression of S100P mRNA; Maneb results in increased expression of S100P protein CTD PMID:32194361 NCBI chr 5:36,919,848...36,924,763
Ensembl chr 5:36,919,961...36,924,039
JBrowse link
G Gmfb glia maturation factor, beta multiple interactions EXP [Paraquat co-treated with Maneb] results in decreased expression of GMFB mRNA; [Paraquat co-treated with Maneb] results in decreased expression of GMFB protein CTD PMID:17532186 NCBI chr14:47,045,606...47,059,711
Ensembl chr14:47,045,606...47,059,699
JBrowse link
G Gng5 guanine nucleotide binding protein (G protein), gamma 5 multiple interactions EXP [Paraquat co-treated with Maneb] results in decreased expression of GNG5 mRNA CTD PMID:18386188 NCBI chr 3:146,205,591...146,211,298
Ensembl chr 3:146,205,562...146,211,327
JBrowse link
G Gngt2 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2 multiple interactions EXP [Paraquat co-treated with Maneb] affects the expression of GNGT2 mRNA CTD PMID:22563483 NCBI chr11:95,733,045...95,736,557
Ensembl chr11:95,728,042...95,736,560
JBrowse link
G Gpr27 G protein-coupled receptor 27 multiple interactions EXP [Paraquat co-treated with Maneb] affects the expression of GPR27 mRNA CTD PMID:22563483 NCBI chr 6:99,669,328...99,672,027
Ensembl chr 6:99,669,640...99,672,027
JBrowse link
G Gpx1 glutathione peroxidase 1 multiple interactions
decreases expression
ISO
EXP
GPX1 protein results in decreased susceptibility to [Paraquat co-treated with Maneb]
[Maneb co-treated with Paraquat] results in increased expression of GPX1 mRNA
Maneb results in decreased expression of GPX1 mRNA
CTD PMID:15824117 PMID:26210702 PMID:29859004 NCBI chr 9:108,216,279...108,217,541
Ensembl chr 9:108,216,102...108,217,542
JBrowse link
G Gpx4 glutathione peroxidase 4 increases expression
multiple interactions
EXP
ISO
Maneb results in increased expression of GPX4 mRNA
[Paraquat co-treated with Maneb] results in decreased expression of GPX4 protein
[Paraquat co-treated with Maneb] results in decreased expression of GPX4 protein; acetovanillone inhibits the reaction [[Paraquat co-treated with Maneb] results in decreased expression of GPX4 protein]; NFE2L2 gene mutant form inhibits the reaction [Maneb results in increased expression of GPX4 mRNA]
CTD PMID:23764462 PMID:30797899 NCBI chr10:79,883,000...79,892,273
Ensembl chr10:79,883,000...79,892,273
JBrowse link
G Grb2 growth factor receptor bound protein 2 multiple interactions EXP [Maneb co-treated with Paraquat] results in decreased expression of GRB2 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of GRB2 mRNA]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of GRB2 mRNA] CTD PMID:23963992 NCBI chr11:115,534,871...115,599,423
Ensembl chr11:115,534,871...115,599,423
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions EXP [alachlor co-treated with Captan co-treated with Diazinon co-treated with Endosulfan co-treated with mancozeb co-treated with Maneb] affects the phosphorylation of GSK3B protein CTD PMID:19883720 NCBI chr16:37,909,363...38,066,446
Ensembl chr16:37,909,363...38,066,446
JBrowse link
G Gsr glutathione reductase multiple interactions ISO
EXP
[Acetylcysteine co-treated with Paraquat co-treated with Maneb] results in increased activity of GSR protein; [Silymarin co-treated with Maneb] results in increased activity of GSR protein; [Silymarin co-treated with Paraquat co-treated with Maneb] results in increased activity of GSR protein
[NFE2L2 gene mutant form results in increased susceptibility to Maneb] which results in decreased expression of GSR protein
CTD PMID:23159886 PMID:23764462 NCBI chr 8:34,143,266...34,188,190
Ensembl chr 8:34,142,551...34,188,191
JBrowse link
G Gsta3 glutathione S-transferase, alpha 3 increases expression ISO Maneb results in increased expression of GSTA3 mRNA CTD PMID:20888808 NCBI chr 1:21,310,789...21,335,799
Ensembl chr 1:21,310,813...21,335,885
JBrowse link
G Gsta4 glutathione S-transferase, alpha 4 multiple interactions
increases activity
increases expression
ISO [Paraquat co-treated with Maneb] results in increased expression of and results in increased activity of GSTA4 protein; [Paraquat co-treated with Maneb] results in increased expression of GSTA4 mRNA; Acetylcysteine promotes the reaction [[Paraquat co-treated with Maneb] results in increased expression of and results in increased activity of GSTA4 protein]; Acetylcysteine promotes the reaction [[Paraquat co-treated with Maneb] results in increased expression of GSTA4 mRNA]; Acetylcysteine promotes the reaction [Maneb results in increased expression of and results in increased activity of GSTA4 protein]; Acetylcysteine promotes the reaction [Maneb results in increased expression of GSTA4 mRNA]; Maneb results in increased expression of and results in increased activity of GSTA4 protein; Silymarin promotes the reaction [[Paraquat co-treated with Maneb] results in increased expression of and results in increased activity of GSTA4 protein]; Silymarin promotes the reaction [[Paraquat co-treated with Maneb] results in increased expression of GSTA4 mRNA]; Silymarin promotes the reaction [Maneb results in increased expression of and results in increased activity of GSTA4 protein]; Silymarin promotes the reaction [Maneb results in increased expression of GSTA4 mRNA]
Maneb results in increased activity of GSTA4 protein
Maneb results in increased expression of GSTA4 mRNA; Maneb results in increased expression of GSTA4 protein
CTD PMID:20888808 PMID:23159886 NCBI chr 9:78,099,248...78,116,631
Ensembl chr 9:78,090,056...78,116,631
JBrowse link
G Gstp1 glutathione S-transferase, pi 1 multiple interactions EXP [Maneb co-treated with Paraquat] results in decreased expression of GSTP1 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of GSTP1 mRNA]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of GSTP1 mRNA] CTD PMID:23963992 NCBI chr19:4,085,411...4,087,912
Ensembl chr19:4,085,407...4,087,985
JBrowse link
G Guk1 guanylate kinase 1 multiple interactions EXP [Paraquat co-treated with Maneb] results in decreased expression of GUK1 mRNA CTD PMID:18386188 NCBI chr11:59,074,681...59,083,033
Ensembl chr11:59,074,701...59,083,038
JBrowse link
G H2ac20 H2A clustered histone 20 multiple interactions EXP [Paraquat co-treated with Maneb] affects the expression of H2AC20 mRNA CTD PMID:22563483 NCBI chr 3:96,127,729...96,128,196
Ensembl chr 3:96,127,677...96,128,196
JBrowse link
G H2aw H2A.W histone multiple interactions EXP [Paraquat co-treated with Maneb] affects the expression of H2AC6 mRNA CTD PMID:22563483 NCBI chr11:58,845,511...58,846,018
Ensembl chr11:58,845,511...58,847,656
JBrowse link
G H2bc9 H2B clustered histone 9 multiple interactions EXP [Paraquat co-treated with Maneb] affects the expression of H2BC9 mRNA CTD PMID:22563483 NCBI chr13:23,727,093...23,727,614
Ensembl chr13:23,725,884...23,727,562
JBrowse link
G Hba-a1 hemoglobin alpha, adult chain 1 multiple interactions EXP [Paraquat co-treated with Maneb] results in decreased expression of HBA-A1 mRNA CTD PMID:18386188 NCBI chr11:32,233,672...32,234,486
Ensembl chr11:32,233,511...32,234,465
JBrowse link
G Hdac3 histone deacetylase 3 decreases activity ISO Maneb results in decreased activity of HDAC3 protein CTD PMID:21251949 NCBI chr18:38,070,024...38,088,073
Ensembl chr18:38,068,897...38,088,069
JBrowse link
G Hdac6 histone deacetylase 6 decreases activity ISO Maneb results in decreased activity of HDAC6 protein CTD PMID:21251949 NCBI chr  X:7,796,355...7,814,284
Ensembl chr  X:7,796,359...7,814,128
JBrowse link
G Hes3 hes family bHLH transcription factor 3 multiple interactions EXP [Paraquat co-treated with Maneb] affects the expression of HES3 mRNA CTD PMID:22563483 NCBI chr 4:152,369,707...152,376,377
Ensembl chr 4:152,370,429...152,376,119
JBrowse link
G Hey2 hairy/enhancer-of-split related with YRPW motif 2 multiple interactions EXP [LRRK2 protein mutant form co-treated with Maneb co-treated with Paraquat] results in decreased expression of HEY2 mRNA CTD PMID:23017109 NCBI chr10:30,708,355...30,718,779
Ensembl chr10:30,708,355...30,718,797
JBrowse link
G Heyl hairy/enhancer-of-split related with YRPW motif-like multiple interactions EXP [SNCA protein co-treated with Maneb co-treated with Paraquat] results in decreased expression of HEYL mRNA CTD PMID:23017109 NCBI chr 4:123,127,349...123,143,663
Ensembl chr 4:123,127,349...123,143,668
JBrowse link
G Hk1 hexokinase 1 multiple interactions EXP [Paraquat co-treated with Maneb] results in decreased expression of HK1 mRNA CTD PMID:18386188 NCBI chr10:62,104,634...62,215,699
Ensembl chr10:62,104,634...62,215,687
JBrowse link
G Hmga2 high mobility group AT-hook 2 multiple interactions EXP [Paraquat co-treated with Maneb] results in decreased expression of HMGA2 mRNA CTD PMID:18386188 NCBI chr10:120,197,173...120,312,374
Ensembl chr10:120,197,180...120,312,374
JBrowse link
G Hmgn5 high-mobility group nucleosome binding domain 5 multiple interactions EXP [Paraquat co-treated with Maneb] affects the expression of HMGN5 mRNA CTD PMID:22563483 NCBI chr  X:108,048,143...108,056,986
Ensembl chr  X:108,048,140...108,057,010
JBrowse link
G Hmox1 heme oxygenase 1 increases expression
multiple interactions
ISO
EXP
Maneb results in increased expression of HMOX1 protein
[NFE2L2 gene mutant form results in increased susceptibility to Maneb] which results in decreased expression of HMOX1 protein
CTD PMID:15527874 PMID:23764462 NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217
JBrowse link
G Hnrnpk heterogeneous nuclear ribonucleoprotein K multiple interactions EXP [Paraquat co-treated with Maneb] results in decreased expression of HNRNPK mRNA CTD PMID:18386188 NCBI chr13:58,538,946...58,551,157
Ensembl chr13:58,538,956...58,551,157
JBrowse link
G Hsd11b2 hydroxysteroid 11-beta dehydrogenase 2 decreases activity ISO Maneb results in decreased activity of HSD11B2 protein CTD PMID:22796344 NCBI chr 8:106,245,378...106,250,620
Ensembl chr 8:106,245,387...106,250,620
JBrowse link
G Hsf1 heat shock factor 1 multiple interactions EXP [Maneb co-treated with Paraquat] results in decreased expression of HSF1 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of HSF1 mRNA]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of HSF1 mRNA] CTD PMID:23963992 NCBI chr15:76,361,562...76,385,355
Ensembl chr15:76,361,622...76,386,113
JBrowse link
G Hsp90aa1 heat shock protein 90, alpha (cytosolic), class A member 1 multiple interactions EXP [Maneb co-treated with Paraquat] results in decreased expression of HSP90AA1 mRNA; [Paraquat co-treated with Maneb] results in increased expression of HSP90AA1 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of HSP90AA1 mRNA] CTD PMID:18386188 PMID:23963992 NCBI chr12:110,657,470...110,662,829
Ensembl chr12:110,657,039...110,669,162
JBrowse link
G Hspa1b heat shock protein 1B multiple interactions EXP [Maneb co-treated with Paraquat] results in decreased expression of HSPA1B mRNA; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of HSPA1B mRNA] CTD PMID:23963992 NCBI chr17:35,175,405...35,178,214
Ensembl chr17:35,175,412...35,178,214
JBrowse link
G Hspa5 heat shock protein 5 multiple interactions EXP [Paraquat co-treated with Maneb] results in increased expression of HSPA5 mRNA CTD PMID:18386188 NCBI chr 2:34,662,102...34,666,541
Ensembl chr 2:34,661,982...34,667,559
JBrowse link
G Hspa8 heat shock protein 8 multiple interactions EXP [Paraquat co-treated with Maneb] results in increased expression of HSPA8 mRNA CTD PMID:18386188 NCBI chr 9:40,712,572...40,716,498
Ensembl chr 9:40,712,280...40,721,383
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions EXP [Paraquat co-treated with Maneb] results in increased expression of ICAM1 mRNA; Poloxamer inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of ICAM1 mRNA] CTD PMID:32169474 NCBI chr 9:20,927,236...20,940,110
Ensembl chr 9:20,927,281...20,940,113
JBrowse link
G Icam2 intercellular adhesion molecule 2 multiple interactions EXP [Paraquat co-treated with Maneb] results in increased expression of ICAM2 mRNA; Poloxamer inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of ICAM2 mRNA] CTD PMID:32169474 NCBI chr11:106,268,482...106,278,948
Ensembl chr11:106,268,482...106,278,901
JBrowse link
G Idh3a isocitrate dehydrogenase 3 (NAD+) alpha multiple interactions EXP [Maneb co-treated with Paraquat] results in increased expression of IDH3A protein; Levodopa inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of IDH3A protein]; tetrakis(N-methyl-4-pyridiniumyl)porphine manganese(III) complex inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of IDH3A protein] CTD PMID:23562983 NCBI chr 9:54,493,795...54,511,946
Ensembl chr 9:54,493,618...54,511,945
JBrowse link
G Ier5l immediate early response 5-like multiple interactions EXP [Paraquat co-treated with Maneb] affects the expression of IER5L mRNA CTD PMID:22563483 NCBI chr 2:30,362,643...30,364,211
Ensembl chr 2:30,361,549...30,364,231
JBrowse link
G Ifng interferon gamma multiple interactions EXP [Maneb co-treated with Paraquat] results in increased expression of IFNG mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of IFNG mRNA]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of IFNG mRNA] CTD PMID:23963992 NCBI chr10:118,276,951...118,281,799
Ensembl chr10:118,276,951...118,281,797
JBrowse link
G Igf1 insulin-like growth factor 1 multiple interactions EXP [Maneb co-treated with Paraquat] results in decreased expression of IGF1 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of IGF1 mRNA]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of IGF1 mRNA] CTD PMID:23963992 NCBI chr10:87,694,127...87,772,909
Ensembl chr10:87,694,127...87,772,904
JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases expression
ISO
EXP
[Paraquat co-treated with Maneb] results in increased expression of IL1B mRNA; Acetylcysteine inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of IL1B mRNA]; Silymarin inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of IL1B mRNA]; Silymarin inhibits the reaction [Maneb results in increased expression of IL1B mRNA]
[Maneb co-treated with Paraquat] results in increased expression of IL1B mRNA; [Maneb co-treated with Paraquat] results in increased expression of IL1B protein; [Paraquat co-treated with Maneb] results in increased expression of IL1B mRNA; [Paraquat co-treated with Maneb] results in increased expression of IL1B protein; Glyburide inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of IL1B protein]; Glyburide inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of IL1B protein]; ITGAM protein affects the reaction [[Paraquat co-treated with Maneb] results in increased expression of IL1B mRNA]; ITGAM protein affects the reaction [[Paraquat co-treated with Maneb] results in increased expression of IL1B protein]; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of IL1B mRNA]; Poloxamer inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of IL1B mRNA]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of IL1B mRNA]; Taurine inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of IL1B mRNA]
CTD PMID:23159886 PMID:23963992 PMID:29568078 PMID:32169474 PMID:32375810 More... NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059
JBrowse link
G Il6 interleukin 6 multiple interactions EXP [Paraquat co-treated with Maneb] results in increased expression of IL6 mRNA; Poloxamer inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of IL6 mRNA] CTD PMID:32169474 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979
JBrowse link
G Inhba inhibin beta-A multiple interactions EXP [Maneb co-treated with Paraquat] results in decreased expression of INHBA mRNA; [Paraquat co-treated with Maneb] affects the expression of INHBA mRNA CTD PMID:22563483 PMID:23017109 NCBI chr13:16,178,841...16,206,194
Ensembl chr13:16,186,436...16,206,206
JBrowse link
G Irs2 insulin receptor substrate 2 multiple interactions EXP [Maneb co-treated with Paraquat] results in decreased expression of IRS2 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of IRS2 mRNA] CTD PMID:23963992 NCBI chr 8:11,034,681...11,058,929
Ensembl chr 8:11,034,681...11,058,458
JBrowse link
G Itgam integrin alpha M multiple interactions EXP [Maneb co-treated with Paraquat] results in increased expression of ITGAM protein; [Paraquat co-treated with Maneb] results in increased expression of ITGAM mRNA; [Paraquat co-treated with Maneb] results in increased expression of ITGAM protein; acetovanillone inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of ITGAM protein]; acetovanillone inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of ITGAM protein]; ITGAM protein affects the reaction [[Paraquat co-treated with Maneb] results in increased cleavage of CASP1 protein]; ITGAM protein affects the reaction [[Paraquat co-treated with Maneb] results in increased expression of IL1B mRNA]; ITGAM protein affects the reaction [[Paraquat co-treated with Maneb] results in increased expression of IL1B protein]; ITGAM protein affects the reaction [[Paraquat co-treated with Maneb] results in increased expression of NLRP3 protein]; ITGAM protein affects the reaction [[Paraquat co-treated with Maneb] results in increased expression of TNF mRNA]; Poloxamer inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of ITGAM mRNA] CTD PMID:28202386 PMID:30797899 PMID:32169474 PMID:32375810 NCBI chr 7:127,661,812...127,717,663
Ensembl chr 7:127,661,812...127,717,663
JBrowse link
G Itgb8 integrin beta 8 multiple interactions EXP [Paraquat co-treated with Maneb] affects the expression of ITGB8 mRNA CTD PMID:22563483 NCBI chr12:119,121,921...119,202,891
Ensembl chr12:119,121,757...119,202,537
JBrowse link
G Itpr1 inositol 1,4,5-trisphosphate receptor 1 multiple interactions EXP [Maneb co-treated with Paraquat] results in decreased expression of ITPR1 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of ITPR1 mRNA] CTD PMID:23963992 NCBI chr 6:108,190,044...108,528,077
Ensembl chr 6:108,190,057...108,528,070
JBrowse link
G Jpt1 Jupiter microtubule associated homolog 1 multiple interactions EXP [Paraquat co-treated with Maneb] results in decreased expression of JPT1 mRNA CTD PMID:18386188 NCBI chr11:115,388,171...115,405,219
Ensembl chr11:115,388,179...115,405,213
JBrowse link
G Jun jun proto-oncogene multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of JUN mRNA; [Paraquat co-treated with Maneb] results in decreased expression of JUN protein; Taurine inhibits the reaction [[Paraquat co-treated with Maneb] results in decreased expression of JUN mRNA]; Taurine inhibits the reaction [[Paraquat co-treated with Maneb] results in decreased expression of JUN protein] CTD PMID:27460631 PMID:33368748 NCBI chr 4:94,937,273...94,940,459
Ensembl chr 4:94,937,271...94,940,459
JBrowse link
G Kcna2 potassium voltage-gated channel, shaker-related subfamily, member 2 multiple interactions EXP [Paraquat co-treated with Maneb] affects the expression of KCNA2 mRNA CTD PMID:22563483 NCBI chr 3:106,998,203...107,022,321
Ensembl chr 3:107,008,462...107,022,321
JBrowse link
G Kcnma1 potassium large conductance calcium-activated channel, subfamily M, alpha member 1 multiple interactions EXP [Paraquat co-treated with Maneb] affects the expression of KCNMA1 mRNA CTD PMID:22563483 NCBI chr14:23,342,356...24,055,173
Ensembl chr14:23,339,499...24,064,559
JBrowse link
G Kif1b kinesin family member 1B multiple interactions EXP [Paraquat co-treated with Maneb] affects the expression of KIF1B mRNA CTD PMID:22563483 NCBI chr 4:149,260,776...149,392,762
Ensembl chr 4:149,260,776...149,392,150
JBrowse link
G Kit KIT proto-oncogene receptor tyrosine kinase decreases expression ISO Maneb results in decreased expression of KIT CTD PMID:25803990 NCBI chr 5:75,735,647...75,817,382
Ensembl chr 5:75,735,576...75,817,382
JBrowse link
G Klf2 Kruppel-like factor 2 (lung) multiple interactions EXP [Paraquat co-treated with Maneb] affects the expression of KLF2 mRNA CTD PMID:22563483 NCBI chr 8:73,072,906...73,075,498
Ensembl chr 8:73,072,877...73,075,500
JBrowse link
G Klhl15 kelch-like 15 multiple interactions EXP [Paraquat co-treated with Maneb] affects the expression of KLHL15 mRNA CTD PMID:22563483 NCBI chr  X:93,275,884...93,321,330
Ensembl chr  X:93,278,205...93,321,330
JBrowse link
G Lamc2 laminin, gamma 2 multiple interactions EXP [Paraquat co-treated with Maneb] affects the expression of LAMC2 mRNA CTD PMID:22563483 NCBI chr 1:152,998,502...153,062,193
Ensembl chr 1:152,998,502...153,062,193
JBrowse link
G Lifr LIF receptor alpha multiple interactions EXP [Paraquat co-treated with Maneb] affects the expression of LIFR mRNA CTD PMID:22563483 NCBI chr15:7,120,091...7,226,970
Ensembl chr15:7,120,095...7,226,970
JBrowse link
G Limk2 LIM motif-containing protein kinase 2 multiple interactions EXP [Paraquat co-treated with Maneb] results in decreased expression of LIMK2 mRNA CTD PMID:18386188 NCBI chr11:3,293,297...3,359,249
Ensembl chr11:3,294,256...3,359,189
JBrowse link
G Lor loricrin multiple interactions EXP [Paraquat co-treated with Maneb] affects the expression of LOR mRNA CTD PMID:22563483 NCBI chr 3:91,987,578...91,990,449
Ensembl chr 3:91,987,578...91,990,449
JBrowse link
G Lrp4 low density lipoprotein receptor-related protein 4 multiple interactions EXP [Paraquat co-treated with Maneb] affects the expression of LRP4 mRNA CTD PMID:22563483 NCBI chr 2:91,287,794...91,344,246
Ensembl chr 2:91,287,856...91,344,124
JBrowse link
G Lrrc17 leucine rich repeat containing 17 multiple interactions EXP [Paraquat co-treated with Maneb] results in decreased expression of LRRC17 mRNA CTD PMID:18386188 NCBI chr 5:21,748,525...21,780,909
Ensembl chr 5:21,748,557...21,780,902
JBrowse link
G Lrrc41 leucine rich repeat containing 41 multiple interactions EXP [Paraquat co-treated with Maneb] results in decreased expression of LRRC41 mRNA CTD PMID:18386188 NCBI chr 4:115,932,466...115,954,306
Ensembl chr 4:115,932,466...115,954,240
JBrowse link
G Lrrk2 leucine-rich repeat kinase 2 multiple interactions EXP [LRRK2 protein mutant form co-treated with Maneb co-treated with Paraquat] results in decreased expression of ACHE mRNA; [LRRK2 protein mutant form co-treated with Maneb co-treated with Paraquat] results in decreased expression of BMP4 mRNA; [LRRK2 protein mutant form co-treated with Maneb co-treated with Paraquat] results in decreased expression of CDK5R1 mRNA; [LRRK2 protein mutant form co-treated with Maneb co-treated with Paraquat] results in decreased expression of CDK5RAP1 mRNA; [LRRK2 protein mutant form co-treated with Maneb co-treated with Paraquat] results in decreased expression of CHRM2 mRNA; [LRRK2 protein mutant form co-treated with Maneb co-treated with Paraquat] results in decreased expression of EFNB1 mRNA; [LRRK2 protein mutant form co-treated with Maneb co-treated with Paraquat] results in decreased expression of FEZ1 mRNA; [LRRK2 protein mutant form co-treated with Maneb co-treated with Paraquat] results in decreased expression of HEY2 mRNA; [LRRK2 protein mutant form co-treated with Maneb co-treated with Paraquat] results in decreased expression of NDP mRNA; [LRRK2 protein mutant form co-treated with Maneb co-treated with Paraquat] results in decreased expression of NRG1 mRNA; [LRRK2 protein mutant form co-treated with Maneb co-treated with Paraquat] results in decreased expression of NTN1 mRNA; [LRRK2 protein mutant form co-treated with Maneb co-treated with Paraquat] results in decreased expression of PAX6 mRNA; [LRRK2 protein mutant form co-treated with Maneb co-treated with Paraquat] results in decreased expression of POU3F3 mRNA; [LRRK2 protein mutant form co-treated with Maneb co-treated with Paraquat] results in decreased expression of VEGFA mRNA; LRRK2 protein mutant form inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of CDK5RAP2 mRNA] CTD PMID:23017109 NCBI chr15:91,556,994...91,700,327
Ensembl chr15:91,557,378...91,700,323
JBrowse link
G Lynx1 Ly6/neurotoxin 1 multiple interactions EXP [Paraquat co-treated with Maneb] results in decreased expression of LYNX1 mRNA CTD PMID:18386188 NCBI chr15:74,619,705...74,624,828
Ensembl chr15:74,619,701...74,624,895
JBrowse link
G Macf1 microtubule-actin crosslinking factor 1 multiple interactions EXP [Paraquat co-treated with Maneb] results in decreased expression of MACF1 mRNA CTD PMID:18386188 NCBI chr 4:123,243,426...123,581,594
NCBI chr 4:123,297,394...123,305,704
Ensembl chr 4:123,243,426...123,578,153
JBrowse link
G Map2 microtubule-associated protein 2 multiple interactions EXP [Maneb co-treated with Paraquat] results in decreased expression of MAP2 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of MAP2 mRNA]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of MAP2 mRNA] CTD PMID:23963992 NCBI chr 1:66,214,337...66,481,742
Ensembl chr 1:66,214,432...66,481,742
JBrowse link
G Map2k1 mitogen-activated protein kinase kinase 1 multiple interactions EXP [Maneb co-treated with Paraquat] results in decreased expression of MAP2K1 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of MAP2K1 mRNA]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of MAP2K1 mRNA] CTD PMID:23963992 NCBI chr 9:64,093,051...64,160,887
Ensembl chr 9:64,093,052...64,160,913
JBrowse link
G Map2k6 mitogen-activated protein kinase kinase 6 multiple interactions EXP [Maneb co-treated with Paraquat] results in increased expression of MAP2K6 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of MAP2K6 mRNA]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of MAP2K6 mRNA] CTD PMID:23963992 NCBI chr11:110,289,928...110,416,348
Ensembl chr11:110,289,948...110,416,348
JBrowse link
G Mapk1 mitogen-activated protein kinase 1 multiple interactions ISO
EXP
[Paraquat co-treated with Maneb] results in increased phosphorylation of MAPK1 protein
[Paraquat co-treated with Maneb] results in increased phosphorylation of MAPK1 protein; acetovanillone inhibits the reaction [[Paraquat co-treated with Maneb] results in increased phosphorylation of MAPK1 protein]
CTD PMID:15824117 PMID:30797899 NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317
JBrowse link
G Mapk15 mitogen-activated protein kinase 15 multiple interactions EXP [Paraquat co-treated with Maneb] affects the expression of MAPK15 mRNA CTD PMID:22563483 NCBI chr15:75,865,581...75,871,002
Ensembl chr15:75,865,618...75,871,003
JBrowse link
G Mapk3 mitogen-activated protein kinase 3 multiple interactions ISO
EXP
[Paraquat co-treated with Maneb] results in increased phosphorylation of MAPK3 protein
[Paraquat co-treated with Maneb] results in increased phosphorylation of MAPK3 protein; acetovanillone inhibits the reaction [[Paraquat co-treated with Maneb] results in increased phosphorylation of MAPK3 protein]
CTD PMID:15824117 PMID:30797899 NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991
JBrowse link
G Mapt microtubule-associated protein tau multiple interactions EXP [Maneb co-treated with Paraquat] results in decreased expression of MAPT mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of MAPT mRNA]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of MAPT mRNA] CTD PMID:23963992 NCBI chr11:104,120,235...104,222,916
Ensembl chr11:104,122,216...104,222,916
JBrowse link
G Marchf9 membrane associated ring-CH-type finger 9 multiple interactions EXP [Paraquat co-treated with Maneb] affects the expression of MARCHF9 mRNA CTD PMID:22563483 NCBI chr10:126,891,919...126,896,053
Ensembl chr10:126,890,880...126,896,053
JBrowse link
G Mbd3 methyl-CpG binding domain protein 3 multiple interactions EXP [Paraquat co-treated with Maneb] results in decreased expression of MBD3 mRNA; [Paraquat co-treated with Maneb] results in increased expression of MBD3 mRNA CTD PMID:18386188 NCBI chr10:80,228,373...80,235,365
Ensembl chr10:80,228,373...80,235,384
JBrowse link
G Mbnl1 muscleblind like splicing factor 1 multiple interactions EXP [Paraquat co-treated with Maneb] results in increased expression of MBNL1 mRNA CTD PMID:18386188 NCBI chr 3:60,380,209...60,537,171
Ensembl chr 3:60,380,251...60,537,171
JBrowse link
G Mboat2 membrane bound O-acyltransferase domain containing 2 multiple interactions EXP [Paraquat co-treated with Maneb] affects the expression of MBOAT2 mRNA CTD PMID:22563483 NCBI chr12:24,881,401...25,014,399
Ensembl chr12:24,880,878...25,014,396
JBrowse link
G Mcl1 myeloid cell leukemia sequence 1 multiple interactions
increases expression
ISO [Paraquat co-treated with Maneb] results in increased expression of MCL1 protein
Maneb results in increased expression of MCL1 protein
CTD PMID:18266926 NCBI chr 3:95,564,017...95,583,553
Ensembl chr 3:95,566,099...95,570,487
JBrowse link
G Mdm4 transformed mouse 3T3 cell double minute 4 multiple interactions EXP [Paraquat co-treated with Maneb] results in decreased expression of MDM4 mRNA CTD PMID:18386188 NCBI chr 1:132,913,843...132,958,325
Ensembl chr 1:132,887,222...132,958,299
JBrowse link
G Mef2c myocyte enhancer factor 2C multiple interactions ISO [Maneb promotes the reaction [SNCA gene mutant form results in increased susceptibility to Paraquat]] which results in increased metabolism of MEF2C protein; [Paraquat promotes the reaction [SNCA gene mutant form results in increased susceptibility to Maneb]] which results in increased metabolism of MEF2C protein CTD PMID:24290359 NCBI chr13:83,652,136...83,815,198
Ensembl chr13:83,652,153...83,815,199
JBrowse link
G Mfge8 milk fat globule EGF and factor V/VIII domain containing multiple interactions EXP [Paraquat co-treated with Maneb] results in decreased expression of MFGE8 mRNA CTD PMID:18386188 NCBI chr 7:78,783,516...78,798,808
Ensembl chr 7:78,783,516...78,798,808
JBrowse link
G Mrc1 mannose receptor, C type 1 multiple interactions EXP [Paraquat co-treated with Maneb] results in increased expression of MRC1 mRNA CTD PMID:29568078 NCBI chr 2:14,234,225...14,336,834
Ensembl chr 2:14,234,203...14,336,868
JBrowse link
G Mrpl15 mitochondrial ribosomal protein L15 multiple interactions EXP [Paraquat co-treated with Maneb] results in decreased expression of MRPL15 mRNA CTD PMID:18386188 NCBI chr 1:4,843,421...4,855,973
Ensembl chr 1:4,843,429...4,855,962
JBrowse link
G Mrtfb myocardin related transcription factor B multiple interactions EXP [Paraquat co-treated with Maneb] affects the expression of MRTFB mRNA CTD PMID:22563483 NCBI chr16:13,073,913...13,235,393
Ensembl chr16:13,074,345...13,235,393
JBrowse link
G Mt1 metallothionein 1 multiple interactions EXP [Paraquat co-treated with Maneb] results in decreased expression of MT1 mRNA CTD PMID:18386188 NCBI chr 8:94,905,214...94,906,955
Ensembl chr 8:94,905,710...94,906,955
JBrowse link
G Mthfr methylenetetrahydrofolate reductase multiple interactions EXP [Paraquat co-treated with Maneb] results in decreased expression of MTHFR mRNA CTD PMID:18386188 NCBI chr 4:148,123,534...148,144,019
Ensembl chr 4:148,123,534...148,144,008
JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions
increases expression
EXP [Paraquat co-treated with Maneb] results in increased expression of MTOR protein; Maneb promotes the reaction [Paraquat results in increased expression of MTOR protein]; Paraquat promotes the reaction [Maneb results in increased expression of MTOR protein] CTD PMID:22292029 PMID:26884967 NCBI chr 4:148,533,039...148,642,142
Ensembl chr 4:148,533,068...148,642,140
JBrowse link
G Muc6 mucin 6, gastric multiple interactions EXP [Paraquat co-treated with Maneb] affects the expression of MUC6 mRNA CTD PMID:22563483 NCBI chr 7:141,212,404...141,241,659
Ensembl chr 7:141,213,373...141,241,641
JBrowse link
G Myc myelocytomatosis oncogene multiple interactions EXP [alachlor co-treated with Captan co-treated with Diazinon co-treated with Endosulfan co-treated with mancozeb co-treated with Maneb] results in increased expression of MYC protein CTD PMID:19883720 NCBI chr15:61,857,190...61,862,210
Ensembl chr15:61,857,240...61,862,223
JBrowse link
G Ncf1 neutrophil cytosolic factor 1 multiple interactions EXP [Maneb co-treated with Paraquat] affects the localization of NCF1 protein; [Maneb co-treated with Paraquat] results in increased expression of NCF1 protein; [Paraquat co-treated with Maneb] results in increased expression of NCF1 protein; Glyburide inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of NCF1 protein]; Glyburide inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of NCF1 protein]; Taurine inhibits the reaction [[Paraquat co-treated with Maneb] affects the localization of NCF1 protein]; Taurine inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of NCF1 protein] CTD PMID:28202386 PMID:29568078 PMID:32375810 PMID:34052309 NCBI chr 5:134,248,907...134,258,479
Ensembl chr 5:134,248,907...134,258,479
JBrowse link
G Ndp Norrie disease (pseudoglioma) (human) multiple interactions EXP [LRRK2 protein mutant form co-treated with Maneb co-treated with Paraquat] results in decreased expression of NDP mRNA CTD PMID:23017109 NCBI chr  X:16,751,760...16,778,013
Ensembl chr  X:16,751,760...16,778,013
JBrowse link
G Neurod1 neurogenic differentiation 1 multiple interactions EXP [Maneb co-treated with Paraquat] results in decreased expression of NEUROD1 mRNA CTD PMID:23017109 NCBI chr 2:79,282,981...79,286,980
Ensembl chr 2:79,282,865...79,287,095
JBrowse link
G Nfat5 nuclear factor of activated T cells 5 multiple interactions EXP [Paraquat co-treated with Maneb] affects the expression of NFAT5 mRNA CTD PMID:22563483 NCBI chr 8:108,020,072...108,106,149
Ensembl chr 8:108,020,102...108,106,149
JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 increases expression
increases response to substance
multiple interactions
ISO
EXP
[Maneb results in increased expression of NFE2L2 protein] which results in increased expression of GCLC mRNA; [Maneb results in increased expression of NFE2L2 protein] which results in increased expression of NQO1 mRNA; [Maneb results in increased expression of NFE2L2 protein] which results in increased expression of PRDX1 mRNA; [Maneb results in increased expression of NFE2L2 protein] which results in increased expression of TXN1 mRNA; [Maneb results in increased expression of NFE2L2 protein] which results in increased expression of TXNRD1 mRNA; Maneb results in increased expression of NFE2L2 protein
NFE2L2 gene mutant form results in increased susceptibility to Maneb
[NFE2L2 gene mutant form results in increased susceptibility to Maneb] which results in decreased abundance of Glutathione; [NFE2L2 gene mutant form results in increased susceptibility to Maneb] which results in decreased expression of GSR protein; [NFE2L2 gene mutant form results in increased susceptibility to Maneb] which results in decreased expression of HMOX1 protein; [NFE2L2 gene mutant form results in increased susceptibility to Maneb] which results in increased abundance of Manganese; [NFE2L2 gene mutant form results in increased susceptibility to Maneb] which results in increased abundance of Thiobarbituric Acid Reactive Substances; NFE2L2 gene mutant form inhibits the reaction [Maneb results in increased expression of GPX4 mRNA]
CTD PMID:21402726 PMID:23764462 NCBI chr 2:75,505,857...75,535,007
Ensembl chr 2:75,505,857...75,534,985
JBrowse link
G Nfib nuclear factor I/B multiple interactions EXP [Paraquat co-treated with Maneb] affects the expression of NFIB mRNA CTD PMID:22563483 NCBI chr 4:82,208,410...82,424,988
Ensembl chr 4:82,208,410...82,623,987
JBrowse link
G Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 multiple interactions EXP [Maneb co-treated with Paraquat] results in increased expression of NFKB1 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of NFKB1 mRNA]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of NFKB1 mRNA] CTD PMID:23963992 NCBI chr 3:135,290,416...135,397,728
Ensembl chr 3:135,290,416...135,397,308
JBrowse link
G Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha multiple interactions EXP [Maneb co-treated with Paraquat] results in increased phosphorylation of and results in decreased expression of NFKBIA protein; [Paraquat co-treated with Maneb] results in increased degradation of and results in increased phosphorylation of NFKBIA protein; acetovanillone inhibits the reaction [[Maneb co-treated with Paraquat] results in increased phosphorylation of and results in decreased expression of NFKBIA protein]; Taurine inhibits the reaction [[Paraquat co-treated with Maneb] results in increased degradation of and results in increased phosphorylation of NFKBIA protein] CTD PMID:28202386 PMID:29568078 NCBI chr12:55,536,194...55,539,432
Ensembl chr12:55,536,195...55,539,432
JBrowse link
G Ngp neutrophilic granule protein multiple interactions EXP [Paraquat co-treated with Maneb] affects the expression of NGP mRNA CTD PMID:22563483 NCBI chr 9:110,248,876...110,252,080
Ensembl chr 9:110,248,815...110,252,080
JBrowse link
G Nipbl NIPBL cohesin loading factor multiple interactions EXP [Paraquat co-treated with Maneb] affects the expression of NIPBL mRNA CTD PMID:22563483 NCBI chr15:8,319,308...8,494,799
Ensembl chr15:8,320,101...8,473,947
JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions EXP [Maneb co-treated with Paraquat] results in increased expression of NLRP3 protein; [Paraquat co-treated with Maneb] results in increased expression of NLRP3 protein; Glyburide inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of NLRP3 protein]; Glyburide inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of NLRP3 protein]; ITGAM protein affects the reaction [[Paraquat co-treated with Maneb] results in increased expression of NLRP3 protein] CTD PMID:32375810 PMID:34052309 NCBI chr11:59,432,395...59,457,781
Ensembl chr11:59,432,394...59,457,782
JBrowse link
G Nog noggin multiple interactions EXP [Maneb co-treated with Paraquat] results in decreased expression of NOG mRNA CTD PMID:23017109 NCBI chr11:89,191,464...89,193,385
Ensembl chr11:89,191,464...89,193,158
JBrowse link
G Nos2 nitric oxide synthase 2, inducible multiple interactions
increases expression
EXP
ISO
4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of NOS2 mRNA]; [Maneb co-treated with Paraquat] results in increased expression of NOS2 mRNA; [Maneb co-treated with Paraquat] results in increased expression of NOS2 protein; [Paraquat co-treated with Maneb] results in increased expression of NOS2 mRNA; [Paraquat co-treated with Maneb] results in increased expression of NOS2 protein; acetovanillone inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of NOS2 mRNA]; acetovanillone inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of NOS2 mRNA]; Genistein inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of NOS2 mRNA]; Glyburide inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of NOS2 mRNA]; Glyburide inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of NOS2 protein]; Glyburide inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of NOS2 mRNA]; Glyburide inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of NOS2 protein]; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of NOS2 mRNA]; pimagedine inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of NOS2 mRNA]; prolinedithiocarbamate inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of NOS2 mRNA]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of NOS2 mRNA]; Taurine inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of NOS2 mRNA]
[Paraquat co-treated with Maneb] results in increased expression of NOS2 mRNA; Acetylcysteine inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of NOS2 mRNA]; Silymarin inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of NOS2 mRNA]; Silymarin inhibits the reaction [Maneb results in increased expression of NOS2 mRNA]
CTD PMID:20455021 PMID:23159886 PMID:23963992 PMID:28202386 PMID:29568078 More... NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080
JBrowse link
G Nox1 NADPH oxidase 1 multiple interactions ISO [Paraquat co-treated with Maneb] results in increased expression of NOX1 mRNA; acetovanillone inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of NOX1 mRNA]; diphenyleneiodonium inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of NOX1 mRNA] CTD PMID:30797899 NCBI chr  X:132,987,170...133,038,455
Ensembl chr  X:132,987,170...133,122,705
JBrowse link
G Nps neuropeptide S multiple interactions EXP [Paraquat co-treated with Maneb] affects the expression of NPS mRNA CTD PMID:22563483 NCBI chr 7:134,870,348...134,874,671
Ensembl chr 7:134,860,432...134,874,671
JBrowse link
G Nqo1 NAD(P)H dehydrogenase, quinone 1 increases expression ISO [Maneb results in increased expression of NFE2L2 protein] which results in increased expression of NQO1 mRNA CTD PMID:21402726 NCBI chr 8:108,114,856...108,139,012
Ensembl chr 8:108,114,857...108,129,838
JBrowse link
G Nr4a1 nuclear receptor subfamily 4, group A, member 1 multiple interactions EXP [Paraquat co-treated with Maneb] affects the expression of NR4A1 mRNA CTD PMID:22563483 NCBI chr15:101,151,788...101,172,676
Ensembl chr15:101,152,150...101,172,676
JBrowse link
G Nr4a2 nuclear receptor subfamily 4, group A, member 2 multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of NR4A2 mRNA; [Paraquat co-treated with Maneb] results in decreased expression of NR4A2 protein CTD PMID:29152652 NCBI chr 2:56,996,845...57,014,018
Ensembl chr 2:56,996,842...57,014,015
JBrowse link
G Nrg1 neuregulin 1 multiple interactions EXP [LRRK2 protein mutant form co-treated with Maneb co-treated with Paraquat] results in decreased expression of NRG1 mRNA CTD PMID:23017109 NCBI chr 8:32,299,493...33,381,858
Ensembl chr 8:32,304,579...33,374,825
Ensembl chr 8:32,304,579...33,374,825
JBrowse link
G Nrtn neurturin multiple interactions EXP [Paraquat co-treated with Maneb] affects the expression of NRTN mRNA CTD PMID:22563483 NCBI chr17:57,058,323...57,064,548
Ensembl chr17:57,058,325...57,064,530
JBrowse link
G Ntn1 netrin 1 multiple interactions EXP [LRRK2 protein mutant form co-treated with Maneb co-treated with Paraquat] results in decreased expression of NTN1 mRNA; [Maneb co-treated with Paraquat] results in decreased expression of NTN1 mRNA CTD PMID:23017109 NCBI chr11:68,100,190...68,277,652
Ensembl chr11:68,100,190...68,291,649
JBrowse link
G Ntrk2 neurotrophic tyrosine kinase, receptor, type 2 multiple interactions EXP [Maneb co-treated with Paraquat] results in decreased expression of NTRK2 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of NTRK2 mRNA]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of NTRK2 mRNA] CTD PMID:23963992 NCBI chr13:58,954,286...59,281,784
Ensembl chr13:58,954,383...59,281,784
JBrowse link
G Oaz2 ornithine decarboxylase antizyme 2 multiple interactions EXP [Maneb co-treated with Paraquat] results in increased expression of OAZ2 mRNA; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of OAZ2 mRNA] CTD PMID:23963992 NCBI chr 9:65,583,830...65,597,582
Ensembl chr 9:65,575,283...65,597,582
JBrowse link
G P2ry4 pyrimidinergic receptor P2Y, G-protein coupled, 4 multiple interactions EXP [Maneb co-treated with Paraquat] results in decreased expression of P2RY4 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of P2RY4 mRNA] CTD PMID:23963992 NCBI chr  X:99,631,964...99,638,533
Ensembl chr  X:99,633,760...99,638,475
JBrowse link
G Pax5 paired box 5 multiple interactions EXP [SNCA protein co-treated with Maneb co-treated with Paraquat] results in decreased expression of PAX5 mRNA CTD PMID:23017109 NCBI chr 4:44,524,748...44,710,694
Ensembl chr 4:44,524,757...44,710,487
JBrowse link
G Pax6 paired box 6 multiple interactions EXP [LRRK2 protein mutant form co-treated with Maneb co-treated with Paraquat] results in decreased expression of PAX6 mRNA CTD PMID:23017109 NCBI chr 2:105,499,241...105,528,755
Ensembl chr 2:105,499,245...105,527,709
JBrowse link
G Pcdh7 protocadherin 7 multiple interactions EXP [Maneb co-treated with Paraquat] results in increased expression of PCDH7 mRNA; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of PCDH7 mRNA] CTD PMID:23963992 NCBI chr 5:57,873,487...58,290,578
Ensembl chr 5:57,875,309...58,290,572
JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions EXP 3-bromo-7-nitroindazole inhibits the reaction [[Paraquat co-treated with Maneb] results in decreased expression of PCNA protein]; [Paraquat co-treated with Maneb] results in decreased expression of PCNA protein CTD PMID:23985028 NCBI chr 2:132,091,206...132,095,100
Ensembl chr 2:132,091,082...132,095,234
JBrowse link
G Pcp2 Purkinje cell protein 2 (L7) multiple interactions EXP [Paraquat co-treated with Maneb] affects the expression of PCP2 mRNA CTD PMID:22563483 NCBI chr 8:3,673,369...3,675,547
Ensembl chr 8:3,673,371...3,675,545
JBrowse link
G Pdcd10 programmed cell death 10 multiple interactions EXP [Paraquat co-treated with Maneb] results in increased expression of PDCD10 mRNA CTD PMID:18386188 NCBI chr 3:75,423,797...75,464,159
Ensembl chr 3:75,423,797...75,464,163
JBrowse link
G Pde1b phosphodiesterase 1B, Ca2+-calmodulin dependent multiple interactions EXP [Maneb co-treated with Paraquat] results in decreased expression of PDE1B mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of PDE1B mRNA] CTD PMID:23963992 NCBI chr15:103,411,461...103,438,483
Ensembl chr15:103,411,461...103,438,479
JBrowse link
G Pdgfra platelet derived growth factor receptor, alpha polypeptide multiple interactions EXP [Maneb co-treated with Paraquat] results in increased expression of PDGFRA mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of PDGFRA mRNA] CTD PMID:23963992 NCBI chr 5:75,311,988...75,358,867
Ensembl chr 5:75,312,953...75,358,876
JBrowse link
G Pdha1 pyruvate dehydrogenase E1 alpha 1 multiple interactions EXP [Maneb co-treated with Paraquat] results in decreased expression of PDHA1 mRNA; [Maneb co-treated with Paraquat] results in increased expression of PDHA1 protein; Levodopa inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of PDHA1 protein]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of PDHA1 mRNA] CTD PMID:23562983 PMID:23963992 NCBI chr  X:158,905,215...158,921,426
Ensembl chr  X:158,905,205...158,921,409
JBrowse link
G Pdyn prodynorphin multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of PDYN CTD PMID:24376148 NCBI chr 2:129,528,469...129,541,858
Ensembl chr 2:129,528,485...129,541,764
JBrowse link
G Pebp1 phosphatidylethanolamine binding protein 1 multiple interactions EXP [Maneb co-treated with Paraquat] results in decreased expression of PEBP1 protein; Levodopa inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of PEBP1 protein] CTD PMID:23562983 NCBI chr 5:117,420,716...117,425,629
Ensembl chr 5:117,420,719...117,425,690
JBrowse link
G Pgs1 phosphatidylglycerophosphate synthase 1 multiple interactions EXP [Paraquat co-treated with Maneb] results in decreased expression of PGS1 mRNA CTD PMID:18386188 NCBI chr11:117,876,505...117,914,837
Ensembl chr11:117,877,118...117,914,837
JBrowse link
G Pigc phosphatidylinositol glycan anchor biosynthesis, class C multiple interactions EXP [Paraquat co-treated with Maneb] results in increased expression of PIGC mRNA CTD PMID:18386188 NCBI chr 1:161,796,757...161,801,029
Ensembl chr 1:161,796,755...161,801,004
JBrowse link
G Plce1 phospholipase C, epsilon 1 multiple interactions EXP [Paraquat co-treated with Maneb] affects the expression of PLCE1 mRNA CTD PMID:22563483 NCBI chr19:38,469,438...38,773,549
Ensembl chr19:38,469,557...38,773,474
JBrowse link
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 increases expression ISO Maneb results in increased expression of PMAIP1 mRNA; Maneb results in increased expression of PMAIP1 protein CTD PMID:18266926 NCBI chr18:66,591,675...66,598,629
Ensembl chr18:66,591,604...66,598,636
JBrowse link
G Pnoc prepronociceptin multiple interactions ISO [Paraquat co-treated with Maneb] results in increased expression of PNOC CTD PMID:24376148 NCBI chr14:65,638,122...65,663,130
Ensembl chr14:65,638,122...65,662,921
JBrowse link
G Polr1c polymerase (RNA) I polypeptide C multiple interactions EXP [Paraquat co-treated with Maneb] results in decreased expression of POLR1C mRNA CTD PMID:18386188 NCBI chr17:46,554,846...46,558,971
Ensembl chr17:46,554,846...46,558,980
JBrowse link
G Polr2k polymerase (RNA) II (DNA directed) polypeptide K multiple interactions EXP [Paraquat co-treated with Maneb] affects the expression of POLR2K mRNA CTD PMID:22563483 NCBI chr15:36,174,156...36,177,158
Ensembl chr15:36,174,156...36,177,156
JBrowse link
G Pou3f3 POU domain, class 3, transcription factor 3 multiple interactions EXP [LRRK2 protein mutant form co-treated with Maneb co-treated with Paraquat] results in decreased expression of POU3F3 mRNA CTD PMID:23017109 NCBI chr 1:42,734,928...42,739,370
Ensembl chr 1:42,734,085...42,742,336
JBrowse link
G Prdx1 peroxiredoxin 1 increases expression ISO [Maneb results in increased expression of NFE2L2 protein] which results in increased expression of PRDX1 mRNA CTD PMID:21402726 NCBI chr 4:116,542,796...116,557,197
Ensembl chr 4:116,542,741...116,558,019
JBrowse link
G Prdx3 peroxiredoxin 3 multiple interactions EXP [Maneb co-treated with Paraquat] results in decreased expression of PRDX3 protein; Levodopa inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of PRDX3 protein]; Minocycline inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of PRDX3 protein]; tetrakis(N-methyl-4-pyridiniumyl)porphine manganese(III) complex inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of PRDX3 protein] CTD PMID:23562983 NCBI chr19:60,852,504...60,862,976
Ensembl chr19:60,852,489...60,862,994
JBrowse link
G Prkaca protein kinase, cAMP dependent, catalytic, alpha multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of PRKACA mRNA; [Paraquat co-treated with Maneb] results in decreased expression of PRKACA protein; Taurine inhibits the reaction [[Paraquat co-treated with Maneb] results in decreased expression of PRKACA mRNA] CTD PMID:27460631 PMID:33368748 NCBI chr 8:84,699,607...84,723,073
Ensembl chr 8:84,699,622...84,723,072
JBrowse link
G Prkcz protein kinase C, zeta multiple interactions EXP [Paraquat co-treated with Maneb] results in decreased expression of PRKCZ mRNA CTD PMID:18386188 NCBI chr 4:155,344,575...155,445,885
Ensembl chr 4:155,344,586...155,445,818
JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase multiple interactions EXP 3-bromo-7-nitroindazole inhibits the reaction [[Paraquat co-treated with Maneb] results in increased nitrosation of PRKN protein]; [Paraquat co-treated with Maneb] results in increased expression of PRKN protein; [Paraquat co-treated with Maneb] results in increased nitrosation of PRKN protein CTD PMID:22563483 PMID:23985028 NCBI chr17:11,059,227...12,282,257
Ensembl chr17:11,059,271...12,282,248
JBrowse link
G Prl prolactin multiple interactions EXP [Paraquat co-treated with Maneb] affects the expression of PRL mRNA CTD PMID:22563483 NCBI chr13:27,241,553...27,249,187
Ensembl chr13:27,241,553...27,249,188
JBrowse link
G Prr7 proline rich 7 (synaptic) multiple interactions EXP [Paraquat co-treated with Maneb] affects the expression of PRR7 mRNA CTD PMID:22563483 NCBI chr13:55,612,080...55,620,968
Ensembl chr13:55,612,080...55,620,967
JBrowse link
G Psap prosaposin multiple interactions EXP [Paraquat co-treated with Maneb] results in decreased expression of PSAP mRNA CTD PMID:18386188 NCBI chr10:60,113,436...60,138,379
Ensembl chr10:60,113,449...60,138,376
JBrowse link
G Psen1 presenilin 1 multiple interactions EXP [Maneb co-treated with Paraquat] results in increased expression of PSEN1 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of PSEN1 mRNA] CTD PMID:23963992 NCBI chr12:83,734,926...83,781,869
Ensembl chr12:83,734,926...83,781,973
JBrowse link
G Psmb1 proteasome (prosome, macropain) subunit, beta type 1 multiple interactions ISO Maneb inhibits the reaction [Paraquat results in decreased expression of PSMB1 mRNA] CTD PMID:26498265 NCBI chr17:15,695,983...15,718,538
Ensembl chr17:15,695,283...15,720,013
JBrowse link
G Psmc4 proteasome (prosome, macropain) 26S subunit, ATPase, 4 multiple interactions EXP
ISO
[Maneb co-treated with Paraquat] results in decreased expression of PSMC4 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of PSMC4 mRNA]
[Paraquat co-treated with Maneb] results in decreased expression of PSMC4 mRNA
CTD PMID:23963992 PMID:26498265 NCBI chr 7:27,741,127...27,749,517
Ensembl chr 7:27,741,132...27,749,526
JBrowse link
G Ptk2b PTK2 protein tyrosine kinase 2 beta multiple interactions EXP [alachlor co-treated with Captan co-treated with Diazinon co-treated with Endosulfan co-treated with mancozeb co-treated with Maneb] results in decreased expression of PTK2B protein modified form CTD PMID:19883720 NCBI chr14:66,390,706...66,518,549
Ensembl chr14:66,390,706...66,518,501
JBrowse link
G Ptpn4 protein tyrosine phosphatase, non-receptor type 4 affects activity ISO Maneb affects the activity of PTPN4 protein CTD PMID:23611293 NCBI chr 1:119,580,197...119,765,281
Ensembl chr 1:119,580,197...119,765,343
JBrowse link
G Ptpn9 protein tyrosine phosphatase, non-receptor type 9 affects activity ISO Maneb affects the activity of PTPN9 protein CTD PMID:23611293 NCBI chr 9:56,902,252...56,970,092
Ensembl chr 9:56,902,207...56,970,091
JBrowse link
G Raf1 v-raf-leukemia viral oncogene 1 multiple interactions EXP [Maneb co-treated with Paraquat] results in decreased expression of RAF1 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of RAF1 mRNA]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of RAF1 mRNA] CTD PMID:23963992 NCBI chr 6:115,595,530...115,653,596
Ensembl chr 6:115,595,028...115,653,596
JBrowse link
G Rb1 RB transcriptional corepressor 1 multiple interactions
increases expression
ISO [Maneb co-treated with Paraquat] results in increased expression of RB1 mRNA; Acetylcysteine inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of RB1 mRNA]; Acetylcysteine inhibits the reaction [Maneb results in increased expression of RB1 mRNA] CTD PMID:29859004 NCBI chr14:73,430,298...73,563,446
Ensembl chr14:73,421,113...73,563,262
JBrowse link
G Rbx1 ring-box 1 multiple interactions EXP [Paraquat co-treated with Maneb] results in decreased expression of RBX1 mRNA CTD PMID:18386188 NCBI chr15:81,350,517...81,360,570
Ensembl chr15:81,350,497...81,360,570
JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) multiple interactions EXP [Maneb co-treated with Paraquat] results in increased phosphorylation of RELA protein; [Paraquat co-treated with Maneb] results in increased phosphorylation of RELA protein; acetovanillone inhibits the reaction [[Maneb co-treated with Paraquat] results in increased phosphorylation of RELA protein]; Taurine inhibits the reaction [[Paraquat co-treated with Maneb] results in increased phosphorylation of RELA protein] CTD PMID:28202386 PMID:29568078 NCBI chr19:5,687,569...5,698,162
Ensembl chr19:5,687,511...5,698,158
JBrowse link
G Ripk1 receptor (TNFRSF)-interacting serine-threonine kinase 1 multiple interactions EXP [Maneb co-treated with Paraquat] results in increased expression of RIPK1 mRNA; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of RIPK1 mRNA] CTD PMID:23963992 NCBI chr13:34,181,072...34,219,153
Ensembl chr13:34,186,346...34,221,130
JBrowse link
G Rock1 Rho-associated coiled-coil containing protein kinase 1 multiple interactions EXP [Paraquat co-treated with Maneb] affects the expression of ROCK1 mRNA CTD PMID:22563483 NCBI chr18:10,064,401...10,182,225
Ensembl chr18:10,064,401...10,182,045
JBrowse link
G Rpl12 ribosomal protein L12 multiple interactions EXP [Paraquat co-treated with Maneb] results in decreased expression of RPL12 mRNA CTD PMID:18386188 NCBI chr 2:32,851,724...32,854,057
Ensembl chr 2:32,851,571...32,855,357
JBrowse link
G Rpl19 ribosomal protein L19 multiple interactions EXP [Maneb co-treated with Paraquat] results in decreased expression of RPL19 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of RPL19 mRNA] CTD PMID:23963992 NCBI chr11:97,912,829...97,921,319
Ensembl chr11:97,917,536...97,921,318
JBrowse link
G Rpl41 ribosomal protein L41 multiple interactions EXP [Paraquat co-treated with Maneb] results in decreased expression of RPL41 mRNA CTD PMID:18386188 NCBI chr10:128,383,979...128,385,037
Ensembl chr10:128,383,983...128,385,174
JBrowse link
G Rpl8 ribosomal protein L8 multiple interactions EXP [Paraquat co-treated with Maneb] results in decreased expression of RPL8 mRNA CTD PMID:18386188 NCBI chr15:76,788,271...76,790,518
Ensembl chr15:76,788,278...76,790,514
JBrowse link
G Rpl9 ribosomal protein L9 multiple interactions EXP [Paraquat co-treated with Maneb] results in decreased expression of RPL9 mRNA CTD PMID:18386188 NCBI chr 5:65,545,707...65,548,774
Ensembl chr 5:65,545,707...65,548,787
JBrowse link
G Rps12 ribosomal protein S12 multiple interactions EXP [Paraquat co-treated with Maneb] results in decreased expression of RPS12 mRNA CTD PMID:18386188 NCBI chr10:23,661,081...23,663,281
Ensembl chr10:23,661,081...23,663,173
JBrowse link
G Rps15 ribosomal protein S15 multiple interactions EXP [Paraquat co-treated with Maneb] results in decreased expression of RPS15 mRNA CTD PMID:18386188 NCBI chr10:80,128,265...80,129,948
Ensembl chr10:80,128,287...80,129,948
JBrowse link
G Rps27 ribosomal protein S27 multiple interactions EXP [Paraquat co-treated with Maneb] results in decreased expression of RPS27 mRNA CTD PMID:18386188 NCBI chr 3:90,119,974...90,120,955
Ensembl chr 3:90,119,829...90,120,958
JBrowse link
G Rps6ka2 ribosomal protein S6 kinase, polypeptide 2 multiple interactions EXP [Paraquat co-treated with Maneb] results in decreased expression of RPS6KA2 mRNA CTD PMID:18386188 NCBI chr17:7,356,384...7,570,714
Ensembl chr17:7,437,514...7,570,714
JBrowse link
G Rtn4 reticulon 4 multiple interactions EXP [Maneb co-treated with Paraquat] results in increased expression of RTN4 mRNA CTD PMID:23017109 NCBI chr11:29,642,898...29,694,414
Ensembl chr11:29,642,947...29,694,331
JBrowse link
G Rtn4rl2 reticulon 4 receptor-like 2 multiple interactions EXP [Paraquat co-treated with Maneb] affects the expression of RTN4RL2 mRNA CTD PMID:22563483 NCBI chr 2:84,701,653...84,718,985
Ensembl chr 2:84,702,268...84,717,054
JBrowse link
G S100a8 S100 calcium binding protein A8 (calgranulin A) multiple interactions EXP [Paraquat co-treated with Maneb] affects the expression of S100A8 mRNA CTD PMID:22563483 NCBI chr 3:90,576,378...90,577,341
Ensembl chr 3:90,576,285...90,577,342
JBrowse link
G S100a9 S100 calcium binding protein A9 (calgranulin B) multiple interactions EXP [Paraquat co-treated with Maneb] affects the expression of S100A9 mRNA CTD PMID:22563483 NCBI chr 3:90,599,937...90,603,028
Ensembl chr 3:90,599,939...90,603,028
JBrowse link
G Saa2 serum amyloid A 2 multiple interactions EXP [Paraquat co-treated with Maneb] affects the expression of SAA2 mRNA CTD PMID:22563483 NCBI chr 7:46,401,257...46,403,737
Ensembl chr 7:46,401,214...46,403,737
JBrowse link
G Scamp2 secretory carrier membrane protein 2 multiple interactions EXP [Maneb co-treated with Paraquat] results in decreased expression of SCAMP2 mRNA; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of SCAMP2 mRNA] CTD PMID:23963992 NCBI chr 9:57,468,227...57,496,081
Ensembl chr 9:57,468,226...57,496,078
JBrowse link
G Scand1 SCAN domain-containing 1 multiple interactions EXP [Paraquat co-treated with Maneb] affects the expression of SCAND1 mRNA CTD PMID:22563483 NCBI chr 2:156,153,766...156,154,624
Ensembl chr 2:156,153,766...156,154,667
JBrowse link
G Sdhb succinate dehydrogenase complex, subunit B, iron sulfur (Ip) multiple interactions EXP [Paraquat co-treated with Maneb] results in decreased expression of SDHB mRNA CTD PMID:18386188 NCBI chr 4:140,688,582...140,706,509
Ensembl chr 4:140,688,514...140,706,504
JBrowse link
G Sema4d sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D multiple interactions EXP [SNCA protein co-treated with Maneb co-treated with Paraquat] results in decreased expression of SEMA4D mRNA CTD PMID:23017109 NCBI chr13:51,839,565...51,947,823
Ensembl chr13:51,839,565...51,947,783
JBrowse link
G Sirt1 sirtuin 1 decreases activity ISO Maneb results in decreased activity of SIRT1 protein CTD PMID:21251949 NCBI chr10:63,154,784...63,174,814
Ensembl chr10:63,154,784...63,217,483
JBrowse link
G Sirt2 sirtuin 2 decreases activity ISO Maneb results in decreased activity of SIRT2 protein CTD PMID:21251949 NCBI chr 7:28,466,177...28,488,090
Ensembl chr 7:28,466,160...28,488,086
JBrowse link
G Sirt3 sirtuin 3 decreases activity ISO Maneb results in decreased activity of SIRT3 protein CTD PMID:21251949 NCBI chr 7:140,443,576...140,462,222
Ensembl chr 7:140,443,579...140,462,222
JBrowse link
G Slc17a8 solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 8 multiple interactions EXP [Paraquat co-treated with Maneb] affects the expression of SLC17A8 mRNA CTD PMID:22563483 NCBI chr10:89,409,882...89,457,111
Ensembl chr10:89,409,882...89,457,115
JBrowse link
G Slc18a2 solute carrier family 18 (vesicular monoamine), member 2 multiple interactions
decreases expression
EXP [Paraquat co-treated with Maneb] results in decreased expression of SLC18A2 mRNA; Ketoconazole inhibits the reaction [Maneb results in decreased expression of SLC18A2 protein]; Melatonin inhibits the reaction [[Paraquat co-treated with Maneb] results in decreased expression of SLC18A2 mRNA]; Silymarin inhibits the reaction [[Paraquat co-treated with Maneb] results in decreased expression of SLC18A2 mRNA] CTD PMID:18386188 PMID:20964710 PMID:22334051 NCBI chr19:59,249,310...59,284,444
Ensembl chr19:59,249,328...59,284,444
JBrowse link
G Slc22a2 solute carrier family 22 (organic cation transporter), member 2 multiple interactions EXP [Maneb co-treated with Paraquat] results in decreased expression of SLC22A2 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of SLC22A2 mRNA] CTD PMID:23963992 NCBI chr17:12,803,076...12,847,376
Ensembl chr17:12,803,019...12,847,375
JBrowse link
G Slc40a1 solute carrier family 40 (iron-regulated transporter), member 1 multiple interactions EXP [Paraquat co-treated with Maneb] results in decreased expression of SLC40A1 protein; acetovanillone inhibits the reaction [[Paraquat co-treated with Maneb] results in decreased expression of SLC40A1 protein] CTD PMID:30797899 NCBI chr 1:45,947,230...45,965,690
Ensembl chr 1:45,947,228...45,965,683
JBrowse link
G Slc5a7 solute carrier family 5 (choline transporter), member 7 multiple interactions EXP [Paraquat co-treated with Maneb] affects the expression of SLC5A7 mRNA CTD PMID:22563483 NCBI chr17:54,580,618...54,606,071
Ensembl chr17:54,580,618...54,606,062
JBrowse link
G Slc6a2 solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2 multiple interactions EXP [Paraquat co-treated with Maneb] affects the expression of SLC6A2 mRNA CTD PMID:22563483 NCBI chr 8:93,687,100...93,728,295
Ensembl chr 8:93,686,707...93,728,295
JBrowse link
G Slc6a3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 multiple interactions
affects response to substance
EXP
ISO
[Paraquat co-treated with Maneb] results in decreased expression of SLC6A3 mRNA; [Paraquat co-treated with Maneb] results in decreased expression of SLC6A3 protein
SLC6A3 gene polymorphism affects the susceptibility to Maneb
CTD PMID:11124998 PMID:18386188 PMID:19590691 NCBI chr13:73,684,270...73,726,791
Ensembl chr13:73,684,866...73,726,791
JBrowse link
G Slc8a1 solute carrier family 8 (sodium/calcium exchanger), member 1 multiple interactions EXP [Paraquat co-treated with Maneb] affects the expression of SLC8A1 mRNA CTD PMID:22563483 NCBI chr17:81,680,534...82,045,816
Ensembl chr17:81,680,534...82,045,806
JBrowse link
G Snca synuclein, alpha multiple interactions
increases response to substance
EXP
ISO
[Maneb co-treated with Paraquat] results in increased phosphorylation of SNCA protein; [Paraquat co-treated with Maneb] promotes the reaction [SNCA protein binds to SNCA protein]; [Paraquat co-treated with Maneb] results in increased expression of SNCA protein; [SNCA protein co-treated with Maneb co-treated with Paraquat] results in decreased expression of ADORA1 mRNA; [SNCA protein co-treated with Maneb co-treated with Paraquat] results in decreased expression of APBB1 mRNA; [SNCA protein co-treated with Maneb co-treated with Paraquat] results in decreased expression of ASCL1 mRNA; [SNCA protein co-treated with Maneb co-treated with Paraquat] results in decreased expression of BMP2 mRNA; [SNCA protein co-treated with Maneb co-treated with Paraquat] results in decreased expression of BMP4 mRNA; [SNCA protein co-treated with Maneb co-treated with Paraquat] results in decreased expression of DLL1 mRNA; [SNCA protein co-treated with Maneb co-treated with Paraquat] results in decreased expression of DRD2 mRNA; [SNCA protein co-treated with Maneb co-treated with Paraquat] results in decreased expression of DRD5 mRNA; [SNCA protein co-treated with Maneb co-treated with Paraquat] results in decreased expression of HEYL mRNA; [SNCA protein co-treated with Maneb co-treated with Paraquat] results in decreased expression of PAX5 mRNA; [SNCA protein co-treated with Maneb co-treated with Paraquat] results in decreased expression of SEMA4D mRNA; [SNCA protein co-treated with Maneb co-treated with Paraquat] results in decreased expression of VEGFA mRNA; Glyburide inhibits the reaction [[Maneb co-treated with Paraquat] results in increased phosphorylation of SNCA protein]; Glyburide inhibits the reaction [[Paraquat co-treated with Maneb] promotes the reaction [SNCA protein binds to SNCA protein]]; Glyburide inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of SNCA protein]; SNCA protein inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of CDK5RAP2 mRNA]; Taurine inhibits the reaction [[Paraquat co-treated with Maneb] promotes the reaction [SNCA protein binds to SNCA protein]]
SNCA gene mutant form results in increased susceptibility to Maneb
[Maneb promotes the reaction [SNCA gene mutant form results in increased susceptibility to Paraquat]] which results in increased abundance of Nitric Oxide; [Maneb promotes the reaction [SNCA gene mutant form results in increased susceptibility to Paraquat]] which results in increased metabolism of MEF2C protein; [Paraquat promotes the reaction [SNCA gene mutant form results in increased susceptibility to Maneb]] which results in increased abundance of Nitric Oxide; [Paraquat promotes the reaction [SNCA gene mutant form results in increased susceptibility to Maneb]] which results in increased metabolism of MEF2C protein; Maneb promotes the reaction [Paraquat results in increased expression of SNCA protein]; Maneb promotes the reaction [SNCA gene mutant form results in increased susceptibility to Paraquat]; Paraquat promotes the reaction [SNCA gene mutant form results in increased susceptibility to Maneb]; SNCA protein mutant form results in increased susceptibility to [Paraquat co-treated with Maneb]; SNCA protein results in increased susceptibility to [Maneb co-treated with Paraquat]
CTD PMID:23017109 PMID:24290359 PMID:26498265 PMID:27324791 PMID:29568078 More... NCBI chr 6:60,708,557...60,806,839
Ensembl chr 6:60,708,559...60,806,839
JBrowse link
G Sod1 superoxide dismutase 1, soluble multiple interactions ISO
EXP
SOD1 protein results in decreased susceptibility to [Paraquat co-treated with Maneb]
[Maneb co-treated with Paraquat] results in increased expression of SOD1 mRNA
[Paraquat co-treated with Maneb] results in decreased expression of SOD1 mRNA
CTD PMID:15824117 PMID:18386188 PMID:29859004 NCBI chr16:90,017,650...90,023,221
Ensembl chr16:90,017,642...90,023,217
JBrowse link
G Sod2 superoxide dismutase 2, mitochondrial multiple interactions
decreases expression
EXP [Maneb co-treated with Paraquat] results in decreased expression of SOD2 protein; Levodopa inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of SOD2 protein]; Minocycline inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of SOD2 protein]; tetrakis(N-methyl-4-pyridiniumyl)porphine manganese(III) complex inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of SOD2 protein]
Maneb results in decreased expression of SOD2 mRNA
CTD PMID:23562983 PMID:26210702 NCBI chr17:13,226,726...13,237,006
Ensembl chr17:13,225,733...13,258,950
JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions EXP [Maneb co-treated with Paraquat] results in decreased expression of STAT3 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of STAT3 mRNA]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of STAT3 mRNA] CTD PMID:23963992 NCBI chr11:100,777,632...100,830,447
Ensembl chr11:100,775,924...100,830,366
JBrowse link
G Stat4 signal transducer and activator of transcription 4 multiple interactions EXP [Maneb co-treated with Paraquat] results in decreased expression of STAT4 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of STAT4 mRNA]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of STAT4 mRNA] CTD PMID:23963992 NCBI chr 1:52,026,265...52,146,348
Ensembl chr 1:52,026,307...52,146,348
JBrowse link
G Stmn1 stathmin 1 multiple interactions EXP [Maneb co-treated with Paraquat] results in decreased expression of STMN1 protein; Levodopa inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of STMN1 protein]; Minocycline inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of STMN1 protein]; tetrakis(N-methyl-4-pyridiniumyl)porphine manganese(III) complex inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of STMN1 protein] CTD PMID:23562983 NCBI chr 4:134,195,631...134,201,154
Ensembl chr 4:134,195,631...134,201,154
JBrowse link
G Ston2 stonin 2 multiple interactions EXP [Paraquat co-treated with Maneb] affects the expression of STON2 mRNA CTD PMID:22563483 NCBI chr12:91,599,686...91,753,210
Ensembl chr12:91,599,783...91,755,161
JBrowse link
G Strbp spermatid perinuclear RNA binding protein multiple interactions EXP [Paraquat co-treated with Maneb] affects the expression of STRBP mRNA CTD PMID:22563483 NCBI chr 2:37,459,880...37,593,890
Ensembl chr 2:37,373,240...37,593,871
JBrowse link
G Sumo1 small ubiquitin-like modifier 1 multiple interactions EXP [Paraquat co-treated with Maneb] results in decreased expression of SUMO1 mRNA CTD PMID:18386188 NCBI chr 1:59,678,593...59,709,993
Ensembl chr 1:59,625,717...59,709,993
JBrowse link
G Syt5 synaptotagmin V multiple interactions EXP [Maneb co-treated with Paraquat] results in decreased expression of SYT5 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of SYT5 mRNA]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of SYT5 mRNA] CTD PMID:23963992 NCBI chr 7:4,542,764...4,550,540
Ensembl chr 7:4,542,764...4,550,540
JBrowse link
G Tbck TBC1 domain containing kinase multiple interactions EXP [Paraquat co-treated with Maneb] affects the expression of TBCK mRNA CTD PMID:22563483 NCBI chr 3:132,389,874...132,547,451
Ensembl chr 3:132,389,905...132,547,449
JBrowse link
G Tecr trans-2,3-enoyl-CoA reductase multiple interactions EXP [Paraquat co-treated with Maneb] results in decreased expression of TECR mRNA CTD PMID:18386188 NCBI chr 8:84,298,327...84,321,120
Ensembl chr 8:84,298,327...84,334,600
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP [Maneb co-treated with Paraquat] results in increased expression of TGFB1 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of TGFB1 mRNA]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of TGFB1 mRNA] CTD PMID:23963992 NCBI chr 7:25,386,406...25,404,503
Ensembl chr 7:25,386,427...25,404,502
JBrowse link
G Th tyrosine hydroxylase multiple interactions
decreases expression
EXP
ISO
4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of TH protein]; [Paraquat co-treated with Maneb] results in decreased expression of TH protein; [Paraquat co-treated with Maneb] results in increased expression of TH protein; Genistein inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of TH protein]; Ketoconazole inhibits the reaction [Maneb results in decreased expression of TH protein]; Melatonin inhibits the reaction [[Paraquat co-treated with Maneb] results in decreased expression of TH protein]; pimagedine inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of TH protein]; prolinedithiocarbamate inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of TH protein]; Silymarin inhibits the reaction [[Paraquat co-treated with Maneb] results in decreased expression of TH protein]
[Paraquat co-treated with Maneb] results in decreased expression of TH; [Paraquat co-treated with Maneb] results in decreased expression of TH mRNA; [Paraquat co-treated with Maneb] results in decreased expression of TH protein
CTD PMID:11124998 PMID:18386188 PMID:20455021 PMID:20964710 PMID:22334051 More... NCBI chr 7:142,446,516...142,453,732
Ensembl chr 7:142,446,489...142,484,865
JBrowse link
G Timm13 translocase of inner mitochondrial membrane 13 multiple interactions EXP [Paraquat co-treated with Maneb] results in decreased expression of TIMM13 mRNA CTD PMID:18386188 NCBI chr10:80,735,284...80,736,803
Ensembl chr10:80,735,284...80,736,803
JBrowse link
G Tmem42 transmembrane protein 42 multiple interactions EXP [Paraquat co-treated with Maneb] affects the expression of TMEM42 mRNA CTD PMID:22563483 NCBI chr 9:122,850,072...122,852,556
Ensembl chr 9:122,850,391...122,852,770
JBrowse link
G Tnf tumor necrosis factor increases expression
multiple interactions
ISO
EXP
Maneb results in increased expression of TNF mRNA
[Maneb co-treated with Paraquat] results in increased expression of TNF mRNA; [Paraquat co-treated with Maneb] results in increased expression of TNF mRNA; acetovanillone inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of TNF mRNA]; acetovanillone inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of TNF mRNA]; Glyburide inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of TNF mRNA]; Glyburide inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of TNF mRNA]; ITGAM protein affects the reaction [[Paraquat co-treated with Maneb] results in increased expression of TNF mRNA]; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of TNF mRNA]; Poloxamer inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of TNF mRNA]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of TNF mRNA]; Taurine inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of TNF mRNA]
[Paraquat co-treated with Maneb] results in increased expression of TNF mRNA; Acetylcysteine inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of TNF mRNA]; Silymarin inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of TNF mRNA]; Silymarin inhibits the reaction [Maneb results in increased expression of TNF mRNA]
CTD PMID:23159886 PMID:23963992 PMID:28202386 PMID:29568078 PMID:30797899 More... NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983
JBrowse link
G Tnfaip3 tumor necrosis factor, alpha-induced protein 3 multiple interactions EXP [Maneb co-treated with Paraquat] results in increased expression of TNFAIP3 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of TNFAIP3 mRNA] CTD PMID:23963992 NCBI chr10:18,876,658...18,891,158
Ensembl chr10:18,876,658...18,891,405
JBrowse link
G Tnr tenascin R multiple interactions EXP [Maneb co-treated with Paraquat] results in decreased expression of TNR mRNA CTD PMID:23017109 NCBI chr 1:159,351,170...159,759,299
Ensembl chr 1:159,351,339...159,759,299
JBrowse link
G Traf3ip2 TRAF3 interacting protein 2 multiple interactions EXP [Maneb co-treated with Paraquat] results in increased expression of ACT1 protein CTD PMID:23562983 NCBI chr10:39,488,930...39,531,303
Ensembl chr10:39,488,930...39,531,303
JBrowse link
G Traf6 TNF receptor-associated factor 6 multiple interactions EXP [Maneb co-treated with Paraquat] results in increased expression of TRAF6 mRNA; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of TRAF6 mRNA] CTD PMID:23963992 NCBI chr 2:101,508,765...101,532,013
Ensembl chr 2:101,508,774...101,532,014
JBrowse link
G Trp53 transformation related protein 53 multiple interactions EXP 3-bromo-7-nitroindazole inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of TRP53 protein]; [Maneb co-treated with Paraquat] results in increased expression of TRP53 mRNA; [Paraquat co-treated with Maneb] results in decreased expression of TRP53 protein; [Paraquat co-treated with Maneb] results in increased activity of TRP53 protein modified form; [Paraquat co-treated with Maneb] results in increased expression of TRP53 protein; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of TRP53 mRNA]; Melatonin inhibits the reaction [[Paraquat co-treated with Maneb] results in decreased expression of TRP53 protein]; Melatonin inhibits the reaction [[Paraquat co-treated with Maneb] results in increased activity of TRP53 protein modified form]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of TRP53 mRNA]; Silymarin inhibits the reaction [[Paraquat co-treated with Maneb] results in decreased expression of TRP53 protein]; Silymarin inhibits the reaction [[Paraquat co-treated with Maneb] results in increased activity of TRP53 protein modified form] CTD PMID:20964710 PMID:23963992 PMID:23985028 NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699
JBrowse link
G Trpm3 transient receptor potential cation channel, subfamily M, member 3 multiple interactions EXP [Paraquat co-treated with Maneb] affects the expression of TRPM3 mRNA CTD PMID:22563483 NCBI chr19:22,114,789...22,972,774
Ensembl chr19:22,116,410...22,972,774
JBrowse link
G Tuba1a tubulin, alpha 1A multiple interactions EXP [Maneb co-treated with Paraquat] results in increased expression of TUBA1A protein; Levodopa inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of TUBA1A protein]; Minocycline inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of TUBA1A protein]; tetrakis(N-methyl-4-pyridiniumyl)porphine manganese(III) complex inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of TUBA1A protein] CTD PMID:23562983 NCBI chr15:98,847,728...98,851,382
Ensembl chr15:98,847,718...98,851,584
JBrowse link
G Tuba1b tubulin, alpha 1B multiple interactions EXP [Paraquat co-treated with Maneb] results in decreased expression of TUBA1B mRNA CTD PMID:18386188 NCBI chr15:98,829,310...98,832,271
Ensembl chr15:98,829,306...98,832,446
JBrowse link
G Tubb5 tubulin, beta 5 class I multiple interactions EXP [Maneb co-treated with Paraquat] results in decreased expression of TUBB5 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of TUBB5 mRNA] CTD PMID:23963992 NCBI chr17:36,144,812...36,149,193
Ensembl chr17:36,144,813...36,149,198
JBrowse link
G Tusc1 tumor suppressor candidate 1 multiple interactions EXP [Paraquat co-treated with Maneb] affects the expression of TUSC1 mRNA CTD PMID:22563483 NCBI chr 4:93,222,385...93,223,748
Ensembl chr 4:93,222,375...93,223,748
JBrowse link
G Txn1 thioredoxin 1 increases expression ISO [Maneb results in increased expression of NFE2L2 protein] which results in increased expression of TXN1 mRNA CTD PMID:21402726 NCBI chr 4:57,943,373...57,956,411
Ensembl chr 4:57,943,373...57,956,411
JBrowse link
G Txnrd1 thioredoxin reductase 1 increases expression ISO [Maneb results in increased expression of NFE2L2 protein] which results in increased expression of TXNRD1 mRNA CTD PMID:21402726 NCBI chr10:82,669,785...82,733,558
Ensembl chr10:82,669,785...82,733,546
JBrowse link
G Uba1 ubiquitin-like modifier activating enzyme 1 multiple interactions ISO Maneb results in decreased activity of and results in decreased ubiquitination of UBA1 protein CTD PMID:25714994 NCBI chr  X:20,524,541...20,549,418
Ensembl chr  X:20,524,565...20,549,418
JBrowse link
G Ubb ubiquitin B multiple interactions EXP [Maneb co-treated with Paraquat] results in decreased expression of UBB mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of UBB mRNA]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of UBB mRNA] CTD PMID:23963992 NCBI chr11:62,441,997...62,444,039
Ensembl chr11:62,441,997...62,444,039
JBrowse link
G Ubc ubiquitin C multiple interactions EXP [Paraquat co-treated with Maneb] results in increased expression of UBC mRNA CTD PMID:18386188 NCBI chr 5:125,463,029...125,467,081
Ensembl chr 5:125,463,029...125,467,266
JBrowse link
G Ubxn7 UBX domain protein 7 multiple interactions EXP [Paraquat co-treated with Maneb] affects the expression of UBXN7 mRNA CTD PMID:22563483 NCBI chr16:32,151,018...32,212,568
Ensembl chr16:32,151,075...32,212,565
JBrowse link
G Uchl1 ubiquitin carboxy-terminal hydrolase L1 multiple interactions EXP [Maneb co-treated with Paraquat] results in decreased expression of UCHL1 protein; [Paraquat co-treated with Maneb] results in decreased expression of UCHL1 mRNA CTD PMID:18386188 PMID:23562983 NCBI chr 5:66,833,464...66,844,577
Ensembl chr 5:66,833,434...66,844,577
JBrowse link
G Uchl5 ubiquitin carboxyl-terminal esterase L5 multiple interactions EXP [Paraquat co-treated with Maneb] results in increased expression of UCHL5 mRNA CTD PMID:18386188 NCBI chr 1:143,652,993...143,683,204
Ensembl chr 1:143,653,010...143,683,204
JBrowse link
G Unc13c unc-13 homolog C multiple interactions EXP [Paraquat co-treated with Maneb] affects the expression of UNC13C mRNA CTD PMID:22563483 NCBI chr 9:73,386,704...73,915,421
Ensembl chr 9:73,386,704...73,876,248
JBrowse link
G Upf3b UPF3 regulator of nonsense transcripts homolog B (yeast) multiple interactions EXP [Paraquat co-treated with Maneb] results in decreased expression of UPF3B mRNA CTD PMID:18386188 NCBI chr  X:36,355,331...36,374,124
Ensembl chr  X:36,355,331...36,373,975
JBrowse link
G Uqcrc1 ubiquinol-cytochrome c reductase core protein 1 multiple interactions EXP [Maneb co-treated with Paraquat] results in increased expression of UQCRC1 protein; Levodopa inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of UQCRC1 protein]; tetrakis(N-methyl-4-pyridiniumyl)porphine manganese(III) complex inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of UQCRC1 protein] CTD PMID:23562983 NCBI chr 9:108,765,716...108,778,709
Ensembl chr 9:108,765,701...108,778,691
JBrowse link
G Utp14b UTP14B small subunit processome component multiple interactions EXP [Paraquat co-treated with Maneb] affects the expression of UTP14B mRNA CTD PMID:22563483 NCBI chr 1:78,635,542...78,645,318
Ensembl chr 1:78,635,755...78,649,229
JBrowse link
G Vamp5 vesicle-associated membrane protein 5 multiple interactions EXP [Maneb co-treated with Paraquat] results in decreased expression of VAMP5 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of VAMP5 mRNA]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of VAMP5 mRNA] CTD PMID:23963992 NCBI chr 6:72,345,032...72,357,451
Ensembl chr 6:72,345,777...72,357,451
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions EXP [LRRK2 protein mutant form co-treated with Maneb co-treated with Paraquat] results in decreased expression of VEGFA mRNA; [SNCA protein co-treated with Maneb co-treated with Paraquat] results in decreased expression of VEGFA mRNA CTD PMID:23017109 NCBI chr17:46,327,919...46,343,303
Ensembl chr17:46,327,919...46,343,295
JBrowse link
G Vps45 vacuolar protein sorting 45 multiple interactions EXP [Maneb co-treated with Paraquat] results in decreased expression of VPS45 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of VPS45 mRNA] CTD PMID:23963992 NCBI chr 3:95,907,144...95,969,715
Ensembl chr 3:95,907,144...95,965,778
JBrowse link
G Wnt1 wingless-type MMTV integration site family, member 1 multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of WNT1 mRNA; [Paraquat co-treated with Maneb] results in decreased expression of WNT1 protein CTD PMID:29152652 NCBI chr15:98,687,738...98,691,711
Ensembl chr15:98,687,738...98,691,718
JBrowse link
G Wnt5a wingless-type MMTV integration site family, member 5A multiple interactions ISO [Paraquat co-treated with Maneb] results in increased expression of WNT5A mRNA; [Paraquat co-treated with Maneb] results in increased expression of WNT5A protein CTD PMID:29152652 NCBI chr14:28,224,962...28,249,405
Ensembl chr14:28,226,707...28,249,405
JBrowse link
G Zbtb44 zinc finger and BTB domain containing 44 multiple interactions EXP [Paraquat co-treated with Maneb] affects the expression of ZBTB44 mRNA CTD PMID:22563483 NCBI chr 9:30,941,016...30,987,181
Ensembl chr 9:30,941,940...30,987,181
JBrowse link
G Zfp580 zinc finger protein 580 multiple interactions EXP [Paraquat co-treated with Maneb] affects the expression of ZFP580 mRNA CTD PMID:22563483 NCBI chr 7:5,041,682...5,056,722
Ensembl chr 7:5,054,537...5,056,722
JBrowse link
G Zhx3 zinc fingers and homeoboxes 3 multiple interactions EXP [Paraquat co-treated with Maneb] affects the expression of ZHX3 mRNA CTD PMID:22563483 NCBI chr 2:160,612,367...160,714,910
Ensembl chr 2:160,590,628...160,714,918
JBrowse link
manganese dioxide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase decreases expression ISO manganese dioxide results in decreased expression of ACHE protein CTD PMID:23702825 NCBI chr 5:137,286,516...137,292,728
Ensembl chr 5:137,285,781...137,292,728
JBrowse link
G Gpt glutamic pyruvic transaminase, soluble increases activity ISO manganese dioxide results in increased activity of GPT protein CTD PMID:23702825 NCBI chr15:76,580,926...76,583,875
Ensembl chr15:76,579,916...76,583,886
JBrowse link
manganese(0) term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca5 ATP-binding cassette, sub-family A (ABC1), member 5 decreases expression ISO Manganese results in decreased expression of ABCA5 mRNA CTD PMID:17175027 NCBI chr11:110,160,195...110,228,542
Ensembl chr11:110,160,195...110,228,542
JBrowse link
G Abca9 ATP-binding cassette, sub-family A (ABC1), member 9 increases expression ISO Manganese results in increased expression of ABCA9 mRNA CTD PMID:17175027 NCBI chr11:109,990,919...110,059,532
Ensembl chr11:109,991,575...110,059,022
JBrowse link
G Abcb1a ATP-binding cassette, sub-family B (MDR/TAP), member 1A increases activity
increases expression
multiple interactions
ISO Manganese results in increased activity of ABCB1 protein
Manganese results in increased expression of ABCB1A mRNA
[Manganese results in increased activity of ABCB1 protein] which results in increased hydrolysis of Adenosine Triphosphate
CTD PMID:2900677 PMID:26745496 NCBI chr 5:8,617,091...8,798,575
Ensembl chr 5:8,710,077...8,798,575
JBrowse link
G Abcc6 ATP-binding cassette, sub-family C (CFTR/MRP), member 6 multiple interactions ISO Manganese promotes the reaction [8-azidoadenosine 5'-triphosphate binds to ABCC6 protein]; Manganese promotes the reaction [beryllium fluoride promotes the reaction [8-azidoadenosine 5'-triphosphate binds to ABCC6 protein]] CTD PMID:12069597 NCBI chr 7:45,625,804...45,679,915
Ensembl chr 7:45,616,979...45,679,726
JBrowse link
G Abcc8 ATP-binding cassette, sub-family C (CFTR/MRP), member 8 multiple interactions ISO [manganese chloride results in increased abundance of Manganese] which results in increased expression of ABCC8 protein CTD PMID:32659473 NCBI chr 7:45,753,947...45,829,457
Ensembl chr 7:45,753,947...45,829,457
JBrowse link
G Abi2 abl interactor 2 increases expression ISO Manganese results in increased expression of ABI2 mRNA CTD PMID:17175027 NCBI chr 1:60,444,927...60,521,104
Ensembl chr 1:60,448,778...60,520,317
JBrowse link
G Acat2 acetyl-Coenzyme A acetyltransferase 2 decreases expression EXP Manganese results in decreased expression of ACAT2 mRNA CTD PMID:23499988 NCBI chr17:13,161,929...13,179,612
Ensembl chr17:13,161,777...13,179,634
JBrowse link
G Ache acetylcholinesterase multiple interactions
increases activity
ISO
EXP
[manganese chloride results in increased abundance of Manganese] promotes the reaction [Ethanol results in increased activity of ACHE protein]; [manganese chloride results in increased abundance of Manganese] which results in increased activity of ACHE protein; Ethanol promotes the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased activity of ACHE protein]; Taurine inhibits the reaction [Manganese results in increased activity of ACHE protein]
[manganese chloride results in increased abundance of Manganese] which results in decreased activity of ACHE protein; [manganese chloride results in increased abundance of Manganese] which results in increased activity of ACHE protein; [manganese chloride results in increased abundance of Manganese] which results in increased expression of ACHE mRNA alternative form
CTD PMID:24885898 PMID:30738988 PMID:30844427 PMID:32445656 PMID:33314588 NCBI chr 5:137,286,516...137,292,728
Ensembl chr 5:137,285,781...137,292,728
JBrowse link
G Aco1 aconitase 1 decreases activity
increases activity
multiple interactions
ISO Manganese results in decreased activity of ACO1 protein
Manganese results in increased activity of ACO1 protein
Manganese results in increased stability of [ACO1 protein binds to SLC11A2 mRNA]
CTD PMID:16386771 PMID:16545456 PMID:16568477 PMID:16729984 PMID:17469137 NCBI chr 4:40,143,265...40,199,009
Ensembl chr 4:40,143,081...40,198,338
JBrowse link
G Aco2 aconitase 2, mitochondrial multiple interactions
decreases activity
decreases expression
ISO ferric ammonium citrate inhibits the reaction [Manganese results in decreased activity of ACO2 protein]
Iron inhibits the reaction [Manganese results in decreased activity of ACO2 protein]
Manganese results in decreased expression of ACO2 mRNA; Manganese results in decreased expression of ACO2 protein
CTD PMID:9675333 PMID:16625280 PMID:17469137 NCBI chr15:81,756,664...81,799,338
Ensembl chr15:81,756,510...81,799,334
JBrowse link
G Acta1 actin alpha 1, skeletal muscle decreases expression ISO Manganese results in decreased expression of ACTA1 mRNA CTD PMID:26745496 NCBI chr 8:124,618,497...124,621,514
Ensembl chr 8:124,618,508...124,621,490
JBrowse link
G Actr3 ARP3 actin-related protein 3 affects expression ISO Manganese affects the expression of ACTR3 protein CTD PMID:24885898 NCBI chr 1:125,320,642...125,363,464
Ensembl chr 1:125,320,642...125,363,464
JBrowse link
G Adgre1 adhesion G protein-coupled receptor E1 increases expression ISO Manganese results in increased expression of ADGRE1 mRNA CTD PMID:20224926 NCBI chr17:57,665,581...57,790,529
Ensembl chr17:57,665,691...57,790,527
JBrowse link
G Adm adrenomedullin increases expression ISO Manganese results in increased expression of ADM mRNA CTD PMID:17175027 NCBI chr 7:110,226,864...110,229,027
Ensembl chr 7:110,226,868...110,229,027
JBrowse link
G Afp alpha fetoprotein decreases expression ISO Manganese results in decreased expression of AFP mRNA CTD PMID:26745496 NCBI chr 5:90,638,573...90,656,766
Ensembl chr 5:90,638,596...90,656,766
JBrowse link
G Akap7 A kinase (PRKA) anchor protein 7 decreases expression ISO Manganese results in decreased expression of AKAP7 mRNA CTD PMID:17175027 NCBI chr10:25,044,988...25,175,115
Ensembl chr10:25,044,988...25,183,768
JBrowse link
G Akt1 thymoma viral proto-oncogene 1 decreases expression
multiple interactions
increases phosphorylation
ISO
EXP
Manganese results in decreased expression of AKT1 protein
[manganese chloride results in increased abundance of Manganese] which results in decreased phosphorylation of AKT1 protein; benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in decreased phosphorylation of AKT1 protein]
NTF3 protein inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in decreased phosphorylation of AKT1 protein]
Manganese results in increased phosphorylation of AKT1 protein
CTD PMID:17043766 PMID:24845367 PMID:31676349 NCBI chr12:112,620,255...112,641,318
Ensembl chr12:112,620,255...112,641,318
JBrowse link
G Angpt2 angiopoietin 2 decreases expression ISO Manganese results in decreased expression of ANGPT2 mRNA CTD PMID:26745496 NCBI chr 8:18,740,279...18,791,578
Ensembl chr 8:18,740,279...18,791,578
JBrowse link
G Angptl4 angiopoietin-like 4 increases expression ISO Manganese results in increased expression of ANGPTL4 mRNA CTD PMID:17175027 NCBI chr17:33,993,874...34,000,549
Ensembl chr17:33,992,724...34,000,804
JBrowse link
G Ap3b2 adaptor-related protein complex 3, beta 2 subunit increases expression ISO Manganese results in increased expression of AP3B2 mRNA CTD PMID:17175027 NCBI chr 7:81,110,147...81,143,722
Ensembl chr 7:81,110,147...81,143,673
JBrowse link
G Apol8 apolipoprotein L 8 increases expression ISO Manganese results in increased expression of APOL2 mRNA CTD PMID:17175027 NCBI chr15:77,629,309...77,641,306
Ensembl chr15:77,631,998...77,641,203
JBrowse link
G App amyloid beta (A4) precursor protein increases expression ISO Manganese results in increased expression of APP mRNA CTD PMID:18583042 NCBI chr16:84,751,236...84,972,187
Ensembl chr16:84,746,573...84,970,654
JBrowse link
G Aqp4 aquaporin 4 multiple interactions ISO Antioxidants inhibits the reaction [Manganese results in increased expression of AQP4 protein] CTD PMID:20648640 NCBI chr18:15,522,451...15,544,039
Ensembl chr18:15,522,553...15,544,039
JBrowse link
G Arg1 arginase, liver affects binding
multiple interactions
ISO
EXP
Manganese binds to ARG1 protein
[manganese chloride results in increased abundance of Manganese] which results in increased expression of ARG1 mRNA
CTD PMID:15248756 PMID:18802628 PMID:34018660 NCBI chr10:24,791,105...24,803,368
Ensembl chr10:24,791,119...24,803,382
JBrowse link
G Arhgdia Rho GDP dissociation inhibitor (GDI) alpha decreases expression ISO Manganese results in decreased expression of ARHGDIA mRNA CTD PMID:17175027 NCBI chr11:120,468,925...120,472,450
Ensembl chr11:120,468,930...120,472,450
JBrowse link
G Arhgef4 Rho guanine nucleotide exchange factor (GEF) 4 increases expression ISO Manganese results in increased expression of ARHGEF4 mRNA CTD PMID:17175027 NCBI chr 1:34,717,051...34,851,835
Ensembl chr 1:34,717,269...34,852,390
Ensembl chr 1:34,717,269...34,852,390
JBrowse link
G Atf1 activating transcription factor 1 increases phosphorylation
multiple interactions
ISO Manganese results in increased phosphorylation of ATF1 protein
SB 203580 inhibits the reaction [Manganese results in increased phosphorylation of ATF1 protein]
CTD PMID:16787641 NCBI chr15:100,125,740...100,159,129
Ensembl chr15:100,125,700...100,159,125
JBrowse link
G Atf6 activating transcription factor 6 decreases expression ISO Manganese results in decreased expression of ATF6 mRNA CTD PMID:17175027 NCBI chr 1:170,532,026...170,696,414
Ensembl chr 1:170,532,243...170,695,340
JBrowse link
G Atm ataxia telangiectasia mutated decreases expression ISO Manganese results in decreased expression of ATM mRNA CTD PMID:17175027 NCBI chr 9:53,348,422...53,448,125
Ensembl chr 9:53,350,449...53,448,040
JBrowse link
G Atoh8 atonal bHLH transcription factor 8 decreases expression ISO Manganese results in decreased expression of ATOH8 mRNA CTD PMID:26745496 NCBI chr 6:72,183,158...72,212,765
Ensembl chr 6:72,183,161...72,212,561
JBrowse link
G Atp13a2 ATPase type 13A2 affects response to substance
decreases response to substance
ISO ATP13A2 gene polymorphism affects the susceptibility to Manganese
ATP13A2 protein results in decreased susceptibility to Manganese
CTD PMID:22285144 PMID:22847264 NCBI chr 4:140,711,812...140,734,641
Ensembl chr 4:140,714,184...140,734,641
JBrowse link
G Atp1a3 ATPase, Na+/K+ transporting, alpha 3 polypeptide decreases expression
increases methylation
EXP Manganese results in decreased expression of ATP1A3 mRNA
Manganese results in increased methylation of ATP1A3 promoter
CTD PMID:23976782 NCBI chr 7:24,677,592...24,705,502
Ensembl chr 7:24,677,592...24,705,383
JBrowse link
G Atp7a ATPase, Cu++ transporting, alpha polypeptide affects localization
decreases expression
ISO Manganese affects the localization of ATP7A protein
Manganese results in decreased expression of ATP7A mRNA; Manganese results in decreased expression of ATP7A protein
CTD PMID:24614235 NCBI chr  X:105,070,830...105,171,766
Ensembl chr  X:105,070,882...105,168,532
JBrowse link
G Atp7b ATPase, Cu++ transporting, beta polypeptide increases phosphorylation
decreases expression
affects localization
ISO Manganese results in increased phosphorylation of ATP7B protein
Manganese results in decreased expression of ATP7B mRNA; Manganese results in decreased expression of ATP7B protein
Manganese affects the localization of ATP7B protein
CTD PMID:19405516 PMID:24614235 NCBI chr 8:22,482,799...22,550,632
Ensembl chr 8:22,482,801...22,550,321
JBrowse link
G Atp8a1 ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1 decreases expression ISO Manganese results in decreased expression of ATP8A1 mRNA CTD PMID:17175027 NCBI chr 5:67,775,482...68,004,822
Ensembl chr 5:67,775,483...68,004,777
JBrowse link
G Bace1 beta-site APP cleaving enzyme 1 increases expression ISO Manganese results in increased expression of BACE1 mRNA CTD PMID:18583042 NCBI chr 9:45,749,843...45,774,791
Ensembl chr 9:45,749,878...45,775,697
JBrowse link
G Bax BCL2-associated X protein multiple interactions
increases expression
ISO
EXP
[manganese chloride results in increased abundance of Manganese] promotes the reaction [Ethanol results in increased expression of BAX protein]; [manganese chloride results in increased abundance of Manganese] which results in increased expression of BAX protein; [Manganese co-treated with NGF protein] results in increased expression of BAX protein; Ethanol promotes the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased expression of BAX protein]; PPM1D protein inhibits the reaction [[Manganese co-treated with NGF protein] results in increased expression of BAX protein]; Rolipram inhibits the reaction [Manganese results in increased expression of BAX protein]
[manganese chloride results in increased abundance of Manganese] which results in increased expression of BAX protein; benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased expression of BAX protein]
NTF3 protein inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased expression of BAX protein]
CTD PMID:25027559 PMID:25791630 PMID:30844427 PMID:30951808 PMID:31161640 More... NCBI chr 7:45,111,119...45,116,344
Ensembl chr 7:45,111,121...45,116,322
JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 multiple interactions
decreases expression
ISO
EXP
[manganese chloride results in increased abundance of Manganese] promotes the reaction [Ethanol results in decreased expression of BCL2 protein]; [manganese chloride results in increased abundance of Manganese] which results in decreased expression of BCL2 protein; Ethanol promotes the reaction [[manganese chloride results in increased abundance of Manganese] which results in decreased expression of BCL2 protein]; Rolipram inhibits the reaction [Manganese results in decreased expression of BCL2 protein] CTD PMID:30844427 PMID:30951808 PMID:31161640 PMID:31676349 PMID:33314588 NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004
JBrowse link
G Bcl2l1 BCL2-like 1 decreases expression
multiple interactions
ISO Manganese results in decreased expression of BCL2L1 protein
[Manganese co-treated with NGF protein] results in decreased expression of BCL2L1 protein; PPM1D protein inhibits the reaction [[Manganese co-treated with NGF protein] results in decreased expression of BCL2L1 protein]
CTD PMID:25791630 NCBI chr 2:152,600,652...152,675,723
Ensembl chr 2:152,622,588...152,673,648
JBrowse link
G Bdnf brain derived neurotrophic factor multiple interactions
decreases expression
ISO
EXP
[Curcumin co-treated with Manganese] inhibits the reaction [Kainic Acid results in increased expression of BDNF mRNA]; [diacetylcurcumin co-treated with Manganese] inhibits the reaction [Kainic Acid results in increased expression of BDNF mRNA]; [manganese chloride results in increased abundance of Manganese] which results in decreased expression of BDNF protein; [manganese chloride results in increased abundance of Manganese] which results in increased expression of BDNF mRNA; CREB1 protein affects the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased expression of BDNF mRNA]; Rolipram inhibits the reaction [Manganese results in decreased expression of BDNF protein]
Manganese results in decreased expression of BDNF mRNA; Manganese results in decreased expression of BDNF protein
CTD PMID:17827730 PMID:25099302 PMID:29205667 PMID:30951808 PMID:31161640 More... NCBI chr 2:109,505,045...109,557,388
Ensembl chr 2:109,505,045...109,557,352
JBrowse link
G Bnip3 BCL2/adenovirus E1B interacting protein 3 multiple interactions EXP Antioxidants inhibits the reaction [Manganese results in increased expression of BNIP3 protein] CTD PMID:19442826 NCBI chr 7:138,492,565...138,511,235
Ensembl chr 7:138,492,565...138,511,248
JBrowse link
G Bub1 BUB1, mitotic checkpoint serine/threonine kinase decreases expression ISO Manganese results in decreased expression of BUB1 mRNA CTD PMID:17175027 NCBI chr 2:127,642,117...127,673,790
Ensembl chr 2:127,643,036...127,673,785
JBrowse link
G Calcoco2 calcium binding and coiled-coil domain 2 increases expression ISO Manganese results in increased expression of CALCOCO2 mRNA CTD PMID:17175027 NCBI chr11:95,989,742...96,015,362
Ensembl chr11:95,990,152...96,002,790
JBrowse link
G Calr calreticulin affects expression ISO Manganese affects the expression of CALR protein CTD PMID:24885898 NCBI chr 8:85,568,717...85,573,560
Ensembl chr 8:85,568,479...85,573,563
JBrowse link
G Camk2a calcium/calmodulin-dependent protein kinase II alpha decreases phosphorylation ISO Manganese results in decreased phosphorylation of CAMK2A protein CTD PMID:26616912 NCBI chr18:61,058,379...61,121,224
Ensembl chr18:61,058,690...61,121,224
JBrowse link
G Capn1 calpain 1 increases activity
multiple interactions
ISO Manganese results in increased activity of CAPN1 protein
calpain inhibitor III inhibits the reaction [Manganese results in increased activity of CAPN1 protein]
CTD PMID:21985864 NCBI chr19:6,038,573...6,065,855
Ensembl chr19:6,038,573...6,065,927
JBrowse link
G Car8 carbonic anhydrase 8 increases expression ISO Manganese results in increased expression of CAR8 mRNA CTD PMID:26745496 NCBI chr 4:8,141,493...8,239,226
Ensembl chr 4:8,143,362...8,239,041
JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
increases expression
increases cleavage
ISO
EXP
[manganese chloride results in increased abundance of Manganese] promotes the reaction [Ethanol results in increased expression of CASP3 protein]; [manganese chloride results in increased abundance of Manganese] which results in increased cleavage of CASP3 protein; [manganese chloride results in increased abundance of Manganese] which results in increased expression of CASP3 protein; aspartyl-glutamyl-valyl-aspartal inhibits the reaction [Manganese results in increased activity of CASP3 protein]; Deferoxamine inhibits the reaction [Manganese results in increased activity of CASP3 protein]; Ethanol promotes the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased expression of CASP3 protein]; GW 506033X inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased cleavage of CASP3 protein]; Manganese promotes the reaction [SP1 protein modified form binds to CASP3 promoter]; Manganese results in increased expression of and results in increased cleavage of CASP3 protein; pyrazolanthrone inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased cleavage of CASP3 protein]; pyrazolanthrone inhibits the reaction [Manganese results in increased cleavage of CASP3 protein]; pyrazolanthrone inhibits the reaction [Manganese results in increased expression of CASP3 protein]; quinoline-val-asp(OMe)-CH2-OPH inhibits the reaction [Manganese results in increased activity of CASP3 protein]; rhodioloside inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased cleavage of CASP3 protein]; U 0126 inhibits the reaction [Manganese results in increased expression of CASP3 mRNA]; U 0126 inhibits the reaction [Manganese results in increased expression of CASP3 protein]
SNCA protein inhibits the reaction [Manganese results in increased activity of CASP3 protein]
Manganese results in increased expression of CASP3 mRNA; Manganese results in increased expression of CASP3 protein
CTD PMID:11933051 PMID:16787641 PMID:21985864 PMID:22427945 PMID:22841634 More... NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724
JBrowse link
G Casp7 caspase 7 increases activity ISO Manganese results in increased activity of CASP7 protein CTD PMID:22427945 NCBI chr19:56,382,640...56,430,780
Ensembl chr19:56,385,561...56,430,776
JBrowse link
G Casp8 caspase 8 increases activity
multiple interactions
ISO Manganese results in increased activity of CASP8 protein
Rolipram inhibits the reaction [Manganese results in increased activity of CASP8 protein]
CTD PMID:31161640 NCBI chr 1:58,834,398...58,886,662
Ensembl chr 1:58,834,533...58,886,662
JBrowse link
G Casp9 caspase 9 increases cleavage
increases activity
multiple interactions
ISO Manganese results in increased cleavage of CASP9 protein
Manganese results in increased activity of CASP9 protein
SNCA protein inhibits the reaction [Manganese results in increased activity of CASP9 protein]
CTD PMID:16787641 PMID:25416158 NCBI chr 4:141,520,923...141,543,289
Ensembl chr 4:141,520,923...141,543,287
JBrowse link
G Cat catalase multiple interactions
decreases activity
EXP
ISO
[manganese chloride results in increased abundance of Manganese] which results in decreased activity of CAT protein; CAT protein inhibits the reaction [[[PRNP protein binds to Manganese] which co-treated with Hydrogen Peroxide] results in increased cleavage of [PRNP protein binds to PRNP protein]]
Manganese results in decreased activity of CAT protein
[Arsenic co-treated with Cadmium co-treated with Lead co-treated with Mercury co-treated with Chromium co-treated with Nickel co-treated with Manganese co-treated with Iron] results in decreased activity of CAT protein; [manganese chloride results in increased abundance of Manganese] promotes the reaction [Ethanol results in decreased activity of CAT protein]; [manganese chloride results in increased abundance of Manganese] which results in decreased activity of CAT protein; CAT protein inhibits the reaction [Manganese results in increased expression of SLC12A2 protein]; CAT protein inhibits the reaction [Manganese results in increased phosphorylation of and results in increased activity of SLC12A2 protein]; Ethanol promotes the reaction [[manganese chloride results in increased abundance of Manganese] which results in decreased activity of CAT protein]; Silymarin inhibits the reaction [Manganese results in decreased activity of CAT protein]
CTD PMID:16595185 PMID:17176674 PMID:23339144 PMID:25817889 PMID:30844427 More... NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505
JBrowse link
G Cav1 caveolin 1, caveolae protein decreases expression EXP Manganese results in decreased expression of CAV1 mRNA; Manganese results in decreased expression of CAV1 protein CTD PMID:23499988 PMID:23597857 NCBI chr 6:17,306,287...17,341,327
Ensembl chr 6:17,306,334...17,341,451
JBrowse link
G Cav3 caveolin 3 decreases expression EXP Manganese results in decreased expression of CAV3 mRNA; Manganese results in decreased expression of CAV3 protein CTD PMID:23597857 NCBI chr 6:112,436,466...112,449,833
Ensembl chr 6:112,436,466...112,449,833
JBrowse link
G Ccl2 chemokine (C-C motif) ligand 2 increases expression ISO Manganese results in increased expression of CCL2 mRNA CTD PMID:19782702 NCBI chr11:81,926,403...81,928,278
Ensembl chr11:81,926,397...81,928,279
JBrowse link
G Ccl7 chemokine (C-C motif) ligand 7 increases expression ISO Manganese results in increased expression of CCL7 mRNA CTD PMID:17175027 NCBI chr11:81,936,538...81,938,351
Ensembl chr11:81,936,538...81,938,351
JBrowse link
G Ccna1 cyclin A1 increases expression ISO Manganese results in increased expression of CCNA1 mRNA CTD PMID:26745496 NCBI chr 3:54,952,890...54,965,055
Ensembl chr 3:54,952,890...54,962,922
JBrowse link
G Ccnb1 cyclin B1 multiple interactions EXP [manganese chloride results in increased abundance of Manganese] which results in decreased expression of CCNB1 mRNA; [manganese chloride results in increased abundance of Manganese] which results in decreased expression of CCNB1 protein CTD PMID:34822792 NCBI chr13:100,915,247...100,922,994
Ensembl chr13:100,915,158...100,923,078
JBrowse link
G Ccnb2 cyclin B2 decreases expression
multiple interactions
ISO
EXP
Manganese results in decreased expression of CCNB2 mRNA
[manganese chloride results in increased abundance of Manganese] which results in decreased expression of CCNB2 mRNA; [manganese chloride results in increased abundance of Manganese] which results in decreased expression of CCNB2 protein; YTHDC2 protein inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in decreased expression of CCNB2 mRNA]; YTHDC2 protein inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in decreased expression of CCNB2 protein]
CTD PMID:17175027 PMID:34822792 NCBI chr 9:70,314,971...70,328,836
Ensembl chr 9:70,314,974...70,328,829
JBrowse link
G Ccnd1 cyclin D1 increases expression ISO Manganese results in increased expression of CCND1 mRNA CTD PMID:23997110 NCBI chr 7:144,483,668...144,493,568
Ensembl chr 7:144,483,668...144,493,662
JBrowse link
G Cd48 CD48 antigen increases expression ISO Manganese results in increased expression of CD48 mRNA CTD PMID:17175027 NCBI chr 1:171,508,989...171,532,825
Ensembl chr 1:171,509,577...171,532,826
JBrowse link
G Cd8b1 CD8 antigen, beta chain 1 increases expression ISO Manganese results in increased expression of CD8B mRNA; Manganese results in increased expression of CD8B1 mRNA CTD PMID:17175027 NCBI chr 6:71,299,772...71,314,476
Ensembl chr 6:71,299,772...71,314,478
JBrowse link
G Cdkn2c cyclin dependent kinase inhibitor 2C decreases expression ISO Manganese results in decreased expression of CDKN2C mRNA CTD PMID:17175027 NCBI chr 4:109,518,073...109,523,953
Ensembl chr 4:109,518,073...109,524,386
JBrowse link
G Cdkn3 cyclin-dependent kinase inhibitor 3 decreases expression ISO Manganese results in decreased expression of CDKN3 mRNA CTD PMID:17175027 NCBI chr14:46,997,912...47,008,987
Ensembl chr14:46,997,998...47,009,126
JBrowse link
G Cebpd CCAAT/enhancer binding protein (C/EBP), delta increases expression ISO Manganese results in increased expression of CEBPD mRNA CTD PMID:17175027 NCBI chr16:15,705,150...15,707,409
Ensembl chr16:15,705,150...15,708,895
JBrowse link
G Celsr1 cadherin, EGF LAG seven-pass G-type receptor 1 increases expression ISO Manganese results in increased expression of CELSR1 mRNA CTD PMID:17175027 NCBI chr15:85,782,959...85,918,424
Ensembl chr15:85,783,130...85,918,404
JBrowse link
G Cep128 centrosomal protein 128 decreases expression ISO Manganese results in decreased expression of CEP128 mRNA CTD PMID:17175027 NCBI chr12:90,965,264...91,351,207
Ensembl chr12:90,965,266...91,351,183
JBrowse link
G Chat choline acetyltransferase decreases activity
multiple interactions
ISO
EXP
Manganese results in decreased activity of CHAT protein
[manganese chloride results in increased abundance of Manganese] which results in decreased activity of CHAT protein
Taurine inhibits the reaction [Manganese results in decreased activity of CHAT protein]
CTD PMID:24885898 PMID:30738988 NCBI chr14:32,130,160...32,187,866
Ensembl chr14:32,130,160...32,187,946
JBrowse link
G Cks2 CDC28 protein kinase regulatory subunit 2 decreases expression ISO Manganese results in decreased expression of CKS2 mRNA CTD PMID:17175027 NCBI chr13:51,799,268...51,804,698
Ensembl chr13:51,799,268...51,804,696
JBrowse link
G Cldn23 claudin 23 increases expression ISO Manganese results in increased expression of CLDN23 mRNA CTD PMID:26745496 NCBI chr 8:36,291,863...36,293,713
Ensembl chr 8:36,291,866...36,293,713
JBrowse link
G Cln6 ceroid-lipofuscinosis, neuronal 6 increases abundance EXP CLN6 gene mutant form results in increased abundance of Manganese CTD PMID:23789114 NCBI chr 9:62,746,067...62,759,288
Ensembl chr 9:62,746,067...62,759,288
JBrowse link
G Cnot2 CCR4-NOT transcription complex, subunit 2 decreases expression ISO Manganese results in decreased expression of CNOT2 mRNA CTD PMID:17175027 NCBI chr10:116,321,065...116,418,891
Ensembl chr10:116,321,066...116,417,416
JBrowse link
G Cnot6l CCR4-NOT transcription complex, subunit 6-like increases expression ISO Manganese results in increased expression of CNOT6L mRNA CTD PMID:17175027 NCBI chr 5:96,218,192...96,312,044
Ensembl chr 5:96,218,192...96,312,030
JBrowse link
G Col12a1 collagen, type XII, alpha 1 decreases expression ISO Manganese results in decreased expression of COL12A1 mRNA CTD PMID:17175027 NCBI chr 9:79,506,269...79,628,423
Ensembl chr 9:79,506,273...79,626,113
JBrowse link
G Cpm carboxypeptidase M decreases expression ISO Manganese results in decreased expression of CPM mRNA CTD PMID:17175027 NCBI chr10:117,465,405...117,523,257
Ensembl chr10:117,465,405...117,523,257
JBrowse link
G Creb1 cAMP responsive element binding protein 1 increases phosphorylation
decreases phosphorylation
multiple interactions
decreases expression
ISO
EXP
Manganese results in increased phosphorylation of CREB1 protein
Manganese results in decreased phosphorylation of CREB1 protein
[manganese chloride results in increased abundance of Manganese] which results in decreased expression of CREB1 protein; NTF3 protein inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in decreased phosphorylation of CREB1 protein]
[manganese chloride results in increased abundance of Manganese] which results in decreased phosphorylation of CREB1 protein; [manganese chloride results in increased abundance of Manganese] which results in increased phosphorylation of CREB1 protein; benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in decreased phosphorylation of CREB1 protein]
Manganese results in decreased expression of CREB1 mRNA; Manganese results in decreased expression of CREB1 protein
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased phosphorylation of CREB1 protein]; [manganese chloride results in increased abundance of Manganese] which results in increased phosphorylation of CREB1 protein; CREB1 protein affects the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased expression of BDNF mRNA]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased phosphorylation of CREB1 protein]; Rolipram inhibits the reaction [Manganese results in decreased phosphorylation of CREB1 protein]; SB 203580 inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased phosphorylation of CREB1 protein]; SB 203580 inhibits the reaction [Manganese results in increased phosphorylation of CREB1 protein]
CTD PMID:16787641 PMID:29205667 PMID:30951808 PMID:31161640 PMID:31676349 More... NCBI chr 1:64,571,963...64,643,707
Ensembl chr 1:64,571,804...64,643,707
JBrowse link
G Crh corticotropin releasing hormone multiple interactions ISO CRH protein inhibits the reaction [Manganese results in increased chemical synthesis of Cyclic AMP] CTD PMID:2153673 NCBI chr 3:19,747,565...19,749,560
Ensembl chr 3:19,747,565...19,749,560
JBrowse link
G Crym crystallin, mu affects expression ISO Manganese affects the expression of CRYM protein CTD PMID:24885898 NCBI chr 7:119,785,603...119,801,212
Ensembl chr 7:119,785,603...119,801,334
JBrowse link
G Csrp3 cysteine and glycine-rich protein 3 increases expression ISO Manganese results in increased expression of CSRP3 mRNA CTD PMID:26745496 NCBI chr 7:48,480,146...48,497,799
Ensembl chr 7:48,480,146...48,497,781
JBrowse link
G Ctnna1 catenin (cadherin associated protein), alpha 1 decreases expression ISO Manganese results in decreased expression of CTNNA1 mRNA CTD PMID:17175027 NCBI chr18:35,251,955...35,387,829
Ensembl chr18:35,251,912...35,387,832
JBrowse link
G Ctnnb1 catenin (cadherin associated protein), beta 1 decreases expression ISO Manganese results in decreased expression of CTNNB1 mRNA CTD PMID:17175027 NCBI chr 9:120,762,466...120,789,573
Ensembl chr 9:120,758,282...120,789,573
JBrowse link
G Cxcl12 chemokine (C-X-C motif) ligand 12 decreases expression EXP Manganese results in decreased expression of CXCL12 mRNA CTD PMID:23499988 NCBI chr 6:117,145,496...117,158,329
Ensembl chr 6:117,145,496...117,158,328
JBrowse link
G Cxcl14 chemokine (C-X-C motif) ligand 14 increases expression ISO Manganese results in increased expression of CXCL14 mRNA CTD PMID:17175027 NCBI chr13:56,436,456...56,444,624
Ensembl chr13:56,436,456...56,444,364
JBrowse link
G Cxcl15 chemokine (C-X-C motif) ligand 15 increases secretion ISO Manganese results in increased secretion of CXCL8 protein CTD PMID:19263519 NCBI chr 5:90,942,393...90,950,926
Ensembl chr 5:90,942,393...90,950,926
JBrowse link
G Cxcl2 chemokine (C-X-C motif) ligand 2 increases expression ISO Manganese results in increased expression of CXCL2 mRNA CTD PMID:17175027 PMID:19782702 PMID:20224926 NCBI chr 5:91,051,758...91,053,797
Ensembl chr 5:91,051,730...91,053,797
JBrowse link
G Cxcl5 chemokine (C-X-C motif) ligand 5 increases expression ISO Manganese results in increased expression of CXCL6 mRNA CTD PMID:17175027 NCBI chr 5:90,907,157...90,909,484
Ensembl chr 5:90,907,219...90,909,483
JBrowse link
G Cycs cytochrome c, somatic multiple interactions
affects localization
ISO SNCA protein inhibits the reaction [Manganese affects the localization of CYCS protein] CTD PMID:25416158 NCBI chr 6:50,539,543...50,543,549
Ensembl chr 6:50,539,543...50,543,518
JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 decreases expression ISO Manganese results in decreased expression of CYP11A1 protein CTD PMID:25981801 NCBI chr 9:57,905,307...57,934,314
Ensembl chr 9:57,913,694...57,934,306
JBrowse link
G Cyp26b1 cytochrome P450, family 26, subfamily b, polypeptide 1 decreases expression ISO Manganese results in decreased expression of CYP26B1 mRNA CTD PMID:26745496 NCBI chr 6:84,548,396...84,570,890
Ensembl chr 6:84,548,396...84,570,890
JBrowse link
G Cyp2d22 cytochrome P450, family 2, subfamily d, polypeptide 22 decreases response to substance ISO CYP2D6 gene polymorphism results in decreased susceptibility to Manganese CTD PMID:12171760 NCBI chr15:82,254,728...82,264,461
Ensembl chr15:82,254,728...82,264,461
JBrowse link
G Cyp7a1 cytochrome P450, family 7, subfamily a, polypeptide 1 multiple interactions
increases activity
ISO [Manganese co-treated with Bilirubin] results in decreased activity of CYP7A1 protein
Manganese results in increased activity of CYP7A1 protein
CTD PMID:12700418 NCBI chr 4:6,265,612...6,275,632
Ensembl chr 4:6,265,612...6,275,633
JBrowse link
G Dach2 dachshund family transcription factor 2 increases expression ISO Manganese results in increased expression of DACH2 mRNA CTD PMID:17175027 NCBI chr  X:112,207,177...112,746,083
Ensembl chr  X:112,207,207...112,746,083
JBrowse link
G Dctn3 dynactin 3 affects expression ISO Manganese affects the expression of DCTN3 protein CTD PMID:24885898 NCBI chr 4:41,714,798...41,723,213
Ensembl chr 4:41,714,798...41,723,170
JBrowse link
G Ddah1 dimethylarginine dimethylaminohydrolase 1 decreases expression
multiple interactions
EXP Manganese deficiency results in decreased expression of DDAH1 protein
Paroxetine inhibits the reaction [Manganese deficiency results in decreased expression of DDAH1 protein]
CTD PMID:21312047 NCBI chr 3:145,464,447...145,600,032
Ensembl chr 3:145,464,430...145,600,032
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression
multiple interactions
ISO
EXP
Manganese results in increased expression of DDIT3 protein
[manganese chloride results in increased abundance of Manganese] which results in increased expression of DDIT3 mRNA
Manganese results in increased expression of DDIT3 mRNA
CTD PMID:21477646 PMID:23499988 PMID:32574669 NCBI chr10:127,126,662...127,132,160
Ensembl chr10:127,126,643...127,132,157
Ensembl chr10:127,126,643...127,132,157
JBrowse link
G Dld dihydrolipoamide dehydrogenase decreases expression ISO Manganese results in decreased expression of DLD protein CTD PMID:25981801 NCBI chr12:31,381,561...31,401,470
Ensembl chr12:31,381,276...31,401,452
JBrowse link
G Dnah14 dynein, axonemal, heavy chain 14 decreases expression ISO Manganese results in decreased expression of DNAH14 mRNA CTD PMID:17175027 NCBI chr 1:181,404,158...181,642,306
Ensembl chr 1:181,404,124...181,643,339
JBrowse link
G Dnph1 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 decreases expression ISO Manganese results in decreased expression of DNPH1 mRNA CTD PMID:17175027 NCBI chr17:46,807,715...46,810,544
Ensembl chr17:46,807,637...46,810,550
JBrowse link
G Dpp4 dipeptidylpeptidase 4 increases expression ISO Manganese results in increased expression of DPP4 mRNA CTD PMID:17175027 NCBI chr 2:62,160,417...62,242,635
Ensembl chr 2:62,160,417...62,242,575
JBrowse link
G Dr1 down-regulator of transcription 1 decreases expression ISO Manganese results in decreased expression of DR1 mRNA CTD PMID:17175027 NCBI chr 5:108,416,763...108,428,387
Ensembl chr 5:108,416,763...108,428,392
JBrowse link
G Drd2 dopamine receptor D2 decreases expression
affects expression
ISO Manganese results in decreased expression of DRD2 mRNA
Manganese affects the expression of DRD2 protein
CTD PMID:20224926 PMID:33881537 NCBI chr 9:49,251,633...49,319,477
Ensembl chr 9:49,251,927...49,319,477
JBrowse link
G Dscaml1 DS cell adhesion molecule like 1 increases expression ISO Manganese results in increased expression of DSCAML1 mRNA CTD PMID:26745496 NCBI chr 9:45,338,735...45,665,011
Ensembl chr 9:45,337,926...45,665,010
JBrowse link
G Dspp dentin sialophosphoprotein increases expression ISO Manganese results in increased expression of DSPP mRNA CTD PMID:17175027 NCBI chr 5:104,318,569...104,327,993
Ensembl chr 5:104,318,578...104,327,993
JBrowse link
G Dusp1 dual specificity phosphatase 1 multiple interactions
decreases expression
EXP [Manganese co-treated with Lipopolysaccharides] results in decreased expression of DUSP1 mRNA; [Manganese co-treated with Lipopolysaccharides] results in decreased expression of DUSP1 protein
Manganese results in decreased expression of DUSP1 mRNA; Manganese results in decreased expression of DUSP1 protein
CTD PMID:20589745 NCBI chr17:26,724,565...26,727,446
Ensembl chr17:26,724,564...26,781,102
JBrowse link
G Eif2a eukaryotic translation initiation factor 2A increases expression ISO Manganese results in increased expression of EIF2A protein CTD PMID:21477646 NCBI chr 3:58,433,242...58,464,922
Ensembl chr 3:58,433,242...58,464,922
JBrowse link
G Eif2ak2 eukaryotic translation initiation factor 2-alpha kinase 2 multiple interactions ISO [manganese chloride results in increased abundance of Manganese] which results in increased cleavage of EIF2AK2 protein; GW 506033X inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased cleavage of EIF2AK2 protein]; pyrazolanthrone inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased cleavage of EIF2AK2 protein] CTD PMID:32574669 NCBI chr17:79,157,933...79,190,001
Ensembl chr17:79,159,993...79,190,002
JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 multiple interactions ISO [manganese chloride results in increased abundance of Manganese] which results in increased phosphorylation of EIF2AK3 protein CTD PMID:32574669 NCBI chr 6:70,821,468...70,882,225
Ensembl chr 6:70,821,499...70,882,229
JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2, subunit 1 alpha multiple interactions ISO [manganese chloride results in increased abundance of Manganese] which results in increased phosphorylation of EIF2S1 protein CTD PMID:32574669 NCBI chr12:78,908,846...78,933,784
Ensembl chr12:78,908,593...78,933,784
JBrowse link
G Elf1 E74 like ETS transcription factor 1 decreases expression ISO Manganese results in decreased expression of ELF1 mRNA CTD PMID:17175027 NCBI chr14:79,718,632...79,819,931
Ensembl chr14:79,718,634...79,819,934
JBrowse link
G Eml2 echinoderm microtubule associated protein like 2 increases expression ISO Manganese results in increased expression of EML2 mRNA CTD PMID:17175027 NCBI chr 7:18,910,322...18,940,407
Ensembl chr 7:18,910,346...18,940,407
JBrowse link
G Eno1 enolase 1, alpha non-neuron decreases activity EXP Manganese results in decreased activity of ENO1 protein CTD PMID:22191580 NCBI chr 4:150,321,165...150,333,336
Ensembl chr 4:150,321,178...150,333,336
JBrowse link
G Epo erythropoietin increases glycosylation ISO Manganese results in increased glycosylation of EPO protein CTD PMID:16937399 NCBI chr 5:137,481,282...137,484,078
Ensembl chr 5:137,481,282...137,531,504
JBrowse link
G Ercc6l excision repair cross-complementing rodent repair deficiency complementation group 6 like decreases expression ISO Manganese results in decreased expression of ERCC6L mRNA CTD PMID:17175027 NCBI chr  X:101,186,426...101,200,697
Ensembl chr  X:101,185,322...101,200,697
JBrowse link
G Ereg epiregulin increases expression ISO Manganese results in increased expression of EREG mRNA CTD PMID:17175027 NCBI chr 5:91,222,476...91,241,508
Ensembl chr 5:91,222,481...91,241,505
JBrowse link
G Erich1 glutamate rich 1 increases expression ISO Manganese results in increased expression of ERICH1 mRNA CTD PMID:17175027 NCBI chr 8:14,075,051...14,140,393
Ensembl chr 8:14,077,561...14,140,301
JBrowse link
G Esr1 estrogen receptor 1 (alpha) increases expression ISO Manganese results in increased expression of ESR1 protein CTD PMID:24845367 NCBI chr10:4,561,989...4,955,633
Ensembl chr10:4,561,593...4,955,614
JBrowse link
G Exoc6 exocyst complex component 6 decreases expression ISO Manganese results in decreased expression of EXOC6 mRNA CTD PMID:17175027 NCBI chr19:37,525,181...37,672,499
Ensembl chr19:37,509,327...37,672,507
JBrowse link
G Eya4 EYA transcriptional coactivator and phosphatase 4 decreases expression ISO Manganese results in decreased expression of EYA4 mRNA CTD PMID:17175027 NCBI chr10:22,978,861...23,226,785
Ensembl chr10:22,978,862...23,226,684
JBrowse link
G F2 coagulation factor II multiple interactions
increases uptake
ISO 1-Methyl-3-isobutylxanthine inhibits the reaction [F2 protein results in increased uptake of Manganese]; Colforsin inhibits the reaction [F2 protein results in increased uptake of Manganese]; Nickel inhibits the reaction [F2 protein results in increased uptake of Manganese]; Tetradecanoylphorbol Acetate inhibits the reaction [F2 protein results in increased uptake of Manganese] CTD PMID:2125206 NCBI chr 2:91,442,742...91,466,802
Ensembl chr 2:91,455,665...91,466,759
JBrowse link
G Fa2h fatty acid 2-hydroxylase increases expression ISO Manganese results in increased expression of FA2H mRNA CTD PMID:26745496 NCBI chr 8:112,071,770...112,120,453
Ensembl chr 8:112,071,767...112,120,456
JBrowse link
G Fam107a family with sequence similarity 107, member A decreases expression ISO Manganese results in decreased expression of FAM107A mRNA CTD PMID:26745496 NCBI chr14:14,152,166...14,173,503
Ensembl chr14:14,151,750...14,173,499
JBrowse link
G Fam180a family with sequence similarity 180, member A decreases expression ISO Manganese results in decreased expression of FAM180A mRNA CTD PMID:26745496 NCBI chr 6:35,289,678...35,303,076
Ensembl chr 6:35,289,603...35,303,076
JBrowse link
G Fancf Fanconi anemia, complementation group F decreases expression ISO Manganese results in decreased expression of FANCF mRNA CTD PMID:17175027 NCBI chr 7:51,510,325...51,512,015
Ensembl chr 7:51,510,325...51,512,015
JBrowse link
G Fcgr1 Fc receptor, IgG, high affinity I decreases expression ISO Manganese results in decreased expression of FCGR1A mRNA CTD PMID:26745496 NCBI chr 3:96,190,225...96,201,285
Ensembl chr 3:96,190,225...96,201,285
JBrowse link
G Fgfbp1 fibroblast growth factor binding protein 1 decreases expression ISO Manganese results in decreased expression of FGFBP1 mRNA CTD PMID:26745496 NCBI chr 5:44,136,200...44,139,173
Ensembl chr 5:44,136,200...44,139,121
JBrowse link
G Fhl1 four and a half LIM domains 1 decreases expression ISO Manganese results in decreased expression of FHL1 mRNA CTD PMID:17175027 NCBI chr  X:55,776,569...55,838,706
Ensembl chr  X:55,777,147...55,838,706
JBrowse link
G Fibin fin bud initiation factor homolog (zebrafish) increases expression EXP Manganese results in increased expression of FIBIN mRNA CTD PMID:21615908 NCBI chr 2:110,191,270...110,193,338
Ensembl chr 2:110,191,262...110,193,528
JBrowse link
G Flcn folliculin increases expression ISO Manganese results in increased expression of FLCN mRNA CTD PMID:17175027 NCBI chr11:59,682,234...59,706,138
Ensembl chr11:59,682,234...59,700,842
JBrowse link
G Fos FBJ osteosarcoma oncogene multiple interactions
decreases expression
ISO [Curcumin co-treated with Manganese] inhibits the reaction [Kainic Acid results in increased expression of FOS protein]; [diacetylcurcumin co-treated with Manganese] inhibits the reaction [Kainic Acid results in increased expression of FOS protein]
Manganese promotes the reaction [Tetradecanoylphorbol Acetate results in increased activity of [JUN protein binds to FOS protein]]; Manganese promotes the reaction [Tetradecanoylphorbol Acetate results in increased expression of FOS protein]
Manganese results in decreased expression of FOS protein
CTD PMID:17043766 PMID:17827730 PMID:22561169 NCBI chr12:85,520,664...85,524,048
Ensembl chr12:85,520,664...85,524,047
JBrowse link
G Foxn4 forkhead box N4 increases expression ISO Manganese results in increased expression of FOXN4 mRNA CTD PMID:26745496 NCBI chr 5:114,392,225...114,412,486
Ensembl chr 5:114,392,225...114,411,868
JBrowse link
G Foxo3 forkhead box O3 multiple interactions
affects localization
ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Manganese results in increased phosphorylation of FOXO3 protein]; 2-oxothiazolidine-4-carboxylic acid inhibits the reaction [Manganese affects the localization of FOXO3 protein]; 2-oxothiazolidine-4-carboxylic acid inhibits the reaction [Manganese results in increased expression of FOXO3 protein]; Manganese results in increased expression of and results in increased phosphorylation of FOXO3 protein; SB 203580 inhibits the reaction [Manganese results in increased phosphorylation of FOXO3 protein] CTD PMID:24787138 NCBI chr10:42,057,841...42,152,691
Ensembl chr10:42,057,837...42,152,751
JBrowse link
G Foxp2 forkhead box P2 increases expression ISO Manganese results in increased expression of FOXP2 mRNA CTD PMID:17175027 NCBI chr 6:14,901,348...15,441,976
Ensembl chr 6:14,901,348...15,441,976
JBrowse link
G Fth1 ferritin heavy polypeptide 1 decreases expression
increases expression
ISO Manganese results in decreased expression of FTH1 mRNA; Manganese results in decreased expression of FTH1 protein
Manganese results in increased expression of FTH1 protein
CTD PMID:16545456 PMID:16568477 PMID:16740617 PMID:17469137 NCBI chr19:9,957,964...9,962,475
Ensembl chr19:9,957,962...9,962,462
JBrowse link
G Fxyd2 FXYD domain-containing ion transport regulator 2 increases expression ISO Manganese results in increased expression of FXYD2 mRNA CTD PMID:17175027 NCBI chr 9:45,311,007...45,321,576
Ensembl chr 9:45,310,967...45,321,576
JBrowse link
G Gabbr2 gamma-aminobutyric acid (GABA) B receptor, 2 multiple interactions ISO [manganese chloride results in increased abundance of Manganese] which results in increased expression of GABBR2 protein CTD PMID:32659473 NCBI chr 4:46,662,318...46,991,714
Ensembl chr 4:46,662,305...46,991,873
JBrowse link
G Gabra1 gamma-aminobutyric acid (GABA) A receptor, subunit alpha 1 multiple interactions ISO [manganese chloride results in increased abundance of Manganese] which results in decreased expression of GABRA1 protein CTD PMID:32659473 NCBI chr11:42,021,766...42,073,893
Ensembl chr11:42,021,766...42,073,757
JBrowse link
G Gabrg2 gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2 increases expression ISO Manganese results in increased expression of GABRG2 mRNA CTD PMID:17175027 NCBI chr11:41,801,017...41,891,684
Ensembl chr11:41,801,030...41,891,684
JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible 45 alpha increases expression EXP Manganese results in increased expression of GADD45A mRNA CTD PMID:23499988 NCBI chr 6:67,012,080...67,014,391
Ensembl chr 6:67,012,080...67,014,441
JBrowse link
G Gal galanin and GMAP prepropeptide increases expression ISO Manganese results in increased expression of GAL mRNA CTD PMID:17175027 NCBI chr19:3,459,915...3,464,544
Ensembl chr19:3,459,915...3,464,544
JBrowse link
G Gcfc2 GC-rich sequence DNA binding factor 2 decreases expression ISO Manganese results in decreased expression of GCFC2 mRNA CTD PMID:17175027 NCBI chr 6:81,887,543...81,936,079
Ensembl chr 6:81,900,650...81,936,896
JBrowse link
G Gdap2 ganglioside-induced differentiation-associated-protein 2 increases expression ISO Manganese results in increased expression of GDAP2 mRNA CTD PMID:17175027 NCBI chr 3:100,069,697...100,114,305
Ensembl chr 3:100,069,697...100,114,297
JBrowse link
G Gdf15 growth differentiation factor 15 increases expression ISO Manganese results in increased expression of GDF15 mRNA CTD PMID:17175027 NCBI chr 8:71,082,043...71,085,106
Ensembl chr 8:71,082,043...71,085,106
JBrowse link
G Gfap glial fibrillary acidic protein decreases expression
affects expression
increases expression
ISO
EXP
Manganese results in decreased expression of GFAP mRNA
Manganese affects the expression of GFAP protein
Manganese results in increased expression of GFAP mRNA; Manganese results in increased expression of GFAP protein
CTD PMID:19782702 PMID:20224926 PMID:23832297 PMID:24885898 NCBI chr11:102,778,162...102,791,368
Ensembl chr11:102,778,162...102,791,738
JBrowse link
G Gja5 gap junction protein, alpha 5 decreases expression ISO Manganese results in decreased expression of GJA5 mRNA CTD PMID:26745496 NCBI chr 3:96,939,718...96,960,950
Ensembl chr 3:96,812,009...96,984,732
JBrowse link
G Gldn gliomedin decreases expression ISO Manganese results in decreased expression of GLDN mRNA CTD PMID:26745496 NCBI chr 9:54,193,770...54,249,061
Ensembl chr 9:54,193,770...54,249,070
JBrowse link
G Glud1 glutamate dehydrogenase 1 decreases expression
multiple interactions
EXP Manganese deficiency results in decreased expression of GLUD1 protein
Paroxetine inhibits the reaction [Manganese deficiency results in decreased expression of GLUD1 protein]
CTD PMID:21312047 NCBI chr14:34,032,684...34,066,990
Ensembl chr14:34,032,684...34,067,222
JBrowse link
G Glul glutamate-ammonia ligase (glutamine synthetase) affects expression
decreases expression
ISO Manganese affects the expression of GLUL mRNA; Manganese affects the expression of GLUL protein
Manganese results in decreased expression of GLUL mRNA; Manganese results in decreased expression of GLUL protein
CTD PMID:16842851 PMID:16943606 NCBI chr 1:153,775,675...153,785,469
Ensembl chr 1:153,775,690...153,785,469
JBrowse link
G Gnrh1 gonadotropin releasing hormone 1 increases expression ISO Manganese results in increased expression of GNRH1 mRNA CTD PMID:23997110 NCBI chr14:67,982,630...67,986,885
Ensembl chr14:67,982,630...67,986,888
JBrowse link
G Gper1 G protein-coupled estrogen receptor 1 multiple interactions ISO [1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone binds to and results in increased activity of GPER1 protein] which results in decreased susceptibility to Manganese CTD PMID:22645130 NCBI chr 5:139,408,905...139,413,555
Ensembl chr 5:139,408,906...139,413,555
JBrowse link
G Gpr18 G protein-coupled receptor 18 decreases expression ISO Manganese results in decreased expression of GPR18 mRNA CTD PMID:26745496 NCBI chr14:122,148,846...122,153,300
Ensembl chr14:122,148,665...122,153,193
JBrowse link
G Gpr34 G protein-coupled receptor 34 decreases expression ISO Manganese results in decreased expression of GPR34 mRNA CTD PMID:26745496 NCBI chr  X:13,489,777...13,507,098
Ensembl chr  X:13,498,328...13,507,097
JBrowse link
G Grin1 glutamate receptor, ionotropic, NMDA1 (zeta 1) decreases expression ISO Manganese results in decreased expression of GRIN1 mRNA; Manganese results in decreased expression of GRIN1 protein CTD PMID:19643132 PMID:29205667 NCBI chr 2:25,181,189...25,209,199
Ensembl chr 2:25,181,193...25,209,199
JBrowse link
G Grin2a glutamate receptor, ionotropic, NMDA2A (epsilon 1) decreases expression ISO Manganese results in decreased expression of GRIN2A mRNA; Manganese results in decreased expression of GRIN2A protein CTD PMID:19643132 PMID:29205667 NCBI chr16:9,385,765...9,813,744
Ensembl chr16:9,385,762...9,813,424
JBrowse link
G Grin2b glutamate receptor, ionotropic, NMDA2B (epsilon 2) decreases expression ISO Manganese results in decreased expression of GRIN2B mRNA; Manganese results in decreased expression of GRIN2B protein CTD PMID:19643132 PMID:29205667 NCBI chr 6:135,690,219...136,150,658
Ensembl chr 6:135,690,231...136,150,509
JBrowse link
G Gsr glutathione reductase decreases expression
multiple interactions
ISO
EXP
Manganese results in decreased expression of GSR mRNA
[manganese chloride results in increased abundance of Manganese] which results in decreased activity of GSR protein
[Arsenic co-treated with Cadmium co-treated with Lead co-treated with Mercury co-treated with Chromium co-treated with Nickel co-treated with Manganese co-treated with Iron] results in decreased activity of GSR protein
CTD PMID:17175027 PMID:17176674 PMID:32445656 NCBI chr 8:34,143,266...34,188,190
Ensembl chr 8:34,142,551...34,188,191
JBrowse link
G Gstp1 glutathione S-transferase, pi 1 affects response to substance ISO GSTP1 gene polymorphism affects the susceptibility to Manganese CTD PMID:30930959 NCBI chr19:4,085,411...4,087,912
Ensembl chr19:4,085,407...4,087,985
JBrowse link
G Gtf2h1 general transcription factor II H, polypeptide 1 decreases expression ISO Manganese results in decreased expression of GTF2H1 mRNA CTD PMID:17175027 NCBI chr 7:46,445,518...46,473,224
Ensembl chr 7:46,445,527...46,473,224
JBrowse link
G Gucy1a1 guanylate cyclase 1, soluble, alpha 1 multiple interactions ISO Manganese results in increased activity of [GUCY1A1 protein binds to GUCY1B1 protein] CTD PMID:22171090 NCBI chr 3:81,999,734...82,053,253
Ensembl chr 3:81,999,734...82,053,096
JBrowse link
G Gucy1b1 guanylate cyclase 1, soluble, beta 1 multiple interactions ISO Manganese results in increased activity of [GUCY1A1 protein binds to GUCY1B1 protein] CTD PMID:22171090 NCBI chr 3:81,939,311...81,982,018
Ensembl chr 3:81,939,313...81,981,996
JBrowse link
G Hamp hepcidin antimicrobial peptide decreases expression
multiple interactions
EXP Manganese results in decreased expression of HAMP mRNA
[manganese chloride results in increased abundance of Manganese] promotes the reaction [Ethanol results in decreased expression of HAMP protein]; [manganese chloride results in increased abundance of Manganese] which results in decreased expression of HAMP protein
CTD PMID:29020610 PMID:34590183 NCBI chr 7:30,641,793...30,643,454
Ensembl chr 7:30,641,793...30,643,457
JBrowse link
G Hdac1 histone deacetylase 1 multiple interactions ISO Manganese promotes the reaction [RELA protein binds to HDAC1 protein]; Manganese promotes the reaction [YY1 protein binds to HDAC1 protein] CTD PMID:24469401 NCBI chr 4:129,409,897...129,436,439
Ensembl chr 4:129,409,897...129,436,506
JBrowse link
G Heph hephaestin increases expression ISO Manganese results in increased expression of HEPH mRNA CTD PMID:17175027 NCBI chr  X:95,499,042...95,618,091
Ensembl chr  X:95,498,965...95,618,091
JBrowse link
G Hfe homeostatic iron regulator affects abundance EXP HFE protein affects the abundance of Manganese CTD PMID:18317567 NCBI chr13:23,886,017...23,894,837
Ensembl chr13:23,886,017...23,894,837
JBrowse link
G Hif1a hypoxia inducible factor 1, alpha subunit multiple interactions
increases expression
ISO
EXP
Manganese results in increased expression of and results in increased activity of HIF1A protein
[[manganese chloride results in increased abundance of Manganese] which co-treated with Ethanol] results in increased expression of HIF1A protein; [manganese chloride results in increased abundance of Manganese] which results in increased expression of HIF1A protein
Manganese results in increased expression of HIF1A mRNA
CTD PMID:16386771 PMID:17175027 PMID:34590183 NCBI chr12:73,948,098...73,994,328
Ensembl chr12:73,948,149...73,994,304
JBrowse link
G Hif1an hypoxia-inducible factor 1, alpha subunit inhibitor decreases expression ISO Manganese results in decreased expression of HIF1AN mRNA CTD PMID:17175027 NCBI chr19:44,551,293...44,564,713
Ensembl chr19:44,551,289...44,564,713
JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-Coenzyme A reductase multiple interactions
increases activity
ISO [Manganese co-treated with Bilirubin] results in decreased activity of HMGCR protein
Manganese results in increased activity of HMGCR protein
CTD PMID:12700418 NCBI chr13:96,785,470...96,807,444
Ensembl chr13:96,785,475...96,807,444
JBrowse link
G Hmgcs2 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 decreases expression ISO Manganese results in decreased expression of HMGCS2 mRNA CTD PMID:26745496 NCBI chr 3:98,187,747...98,218,054
Ensembl chr 3:98,187,751...98,218,054