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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:manganese molecular entity
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Accession:CHEBI:25154 term browser browse the term
Synonyms:related_synonym: manganese compounds;   manganese molecular entities

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mancozeb term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase affects activity EXP mancozeb affects the activity of ACHE protein CTD PMID:10641187 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753 		JBrowse link
G Actg1 actin, gamma 1 increases expression ISO mancozeb results in increased expression of ACTG1 protein CTD PMID:21375462 NCBI chr10:109,518,429...109,521,288
Ensembl chr 3:75,643,054...75,644,954
Ensembl chr10:75,643,054...75,644,954 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO [alachlor co-treated with Captan co-treated with Diazinon co-treated with Endosulfan co-treated with mancozeb co-treated with Maneb] affects the phosphorylation of AKT1 protein; [alachlor co-treated with Captan co-treated with Diazinon co-treated with Endosulfan co-treated with mancozeb co-treated with Maneb] results in decreased expression of AKT1 protein CTD PMID:19883720 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258 		JBrowse link
G Alb albumin decreases expression ISO mancozeb results in decreased expression of ALB protein CTD PMID:21375462 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863 		JBrowse link
G Aldh2 aldehyde dehydrogenase 2 family member decreases activity EXP mancozeb results in decreased activity of ALDH2 protein CTD PMID:17010440 NCBI chr12:40,466,418...40,498,813
Ensembl chr12:40,466,495...40,498,752 		JBrowse link
G Aldh5a1 aldehyde dehydrogenase 5 family, member A1 decreases activity EXP mancozeb results in decreased activity of ALDH5A1 protein CTD PMID:17010440 NCBI chr17:42,133,076...42,159,413
Ensembl chr17:42,133,076...42,159,413 		JBrowse link
G Anxa2 annexin A2 decreases expression ISO mancozeb results in decreased expression of ANXA2 protein CTD PMID:21375462 NCBI chr 8:75,687,134...75,723,589
Ensembl chr 8:75,687,100...75,723,594 		JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 increases expression ISO mancozeb results in increased expression of APAF1 protein CTD PMID:22289270 NCBI chr 7:31,699,309...31,784,192
Ensembl chr 7:31,699,885...31,784,192 		JBrowse link
G Ar androgen receptor multiple interactions
decreases activity		 ISO mancozeb inhibits the reaction [Dihydrotestosterone binds to and results in increased activity of AR protein]; mancozeb inhibits the reaction [Metribolone binds to and results in increased activity of AR protein]
mancozeb results in decreased activity of AR protein		 CTD PMID:23871939 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression
multiple interactions		 ISO mancozeb results in increased expression of BAX mRNA; mancozeb results in increased expression of BAX protein
lupeol inhibits the reaction [mancozeb results in increased expression of BAX mRNA]		 CTD PMID:22289270 PMID:27235710 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions		 ISO
EXP		 mancozeb results in decreased expression of BCL2 mRNA; mancozeb results in decreased expression of BCL2 protein
lupeol inhibits the reaction [mancozeb results in decreased expression of BCL2 mRNA]
alpha-Tocopherol inhibits the reaction [mancozeb results in decreased expression of BCL2 protein]		 CTD PMID:16005924 PMID:22289270 PMID:27235710 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374 		JBrowse link
G Ca3 carbonic anhydrase 3 increases expression ISO mancozeb results in increased expression of CAR3 protein CTD PMID:21375462 NCBI chr 2:88,126,519...88,136,063
Ensembl chr 2:88,126,667...88,135,410 		JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions
increases cleavage		 ISO mancozeb results in increased activity of CASP3 protein
Acetylcysteine inhibits the reaction [mancozeb results in increased cleavage of CASP3 protein]
mancozeb results in increased cleavage of and results in increased activity of CASP3 protein		 CTD PMID:22289270 PMID:22824503 PMID:30037311 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204 		JBrowse link
G Casp7 caspase 7 increases activity ISO mancozeb results in increased activity of CASP7 protein CTD PMID:22824503 NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774 		JBrowse link
G Casp8 caspase 8 increases activity ISO mancozeb results in increased activity of CASP8 protein CTD PMID:22289270 PMID:22824503 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106 		JBrowse link
G Casp9 caspase 9 increases activity
multiple interactions		 ISO mancozeb results in increased activity of CASP9 protein
mancozeb results in increased cleavage of and results in increased activity of CASP9 protein		 CTD PMID:22289270 PMID:22824503 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778 		JBrowse link
G Cat catalase multiple interactions
decreases activity		 ISO
EXP		 Acetylcysteine inhibits the reaction [mancozeb results in decreased activity of CAT protein]; lupeol inhibits the reaction [mancozeb results in decreased activity of CAT protein]; Quercetin inhibits the reaction [mancozeb results in decreased activity of CAT protein]
Colforsin inhibits the reaction [mancozeb results in decreased activity of CAT protein]		 CTD PMID:23024109 PMID:27235710 PMID:29283200 PMID:30037311 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058 		JBrowse link
G Ccnd1 cyclin D1 multiple interactions
increases expression		 ISO [alachlor co-treated with Captan co-treated with Diazinon co-treated with Endosulfan co-treated with mancozeb co-treated with Maneb] results in increased expression of CCND1 protein
mancozeb results in increased expression of CCND1 protein		 CTD PMID:19883720 PMID:21375462 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325 		JBrowse link
G Cdc25c cell division cycle 25C increases phosphorylation ISO mancozeb results in increased phosphorylation of CDC25C protein CTD PMID:21375462 NCBI chr18:27,528,768...27,550,316
Ensembl chr18:27,528,354...27,550,224 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions
increases expression		 ISO lupeol inhibits the reaction [mancozeb results in increased expression of CDKN1A mRNA] CTD PMID:27235710 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864 		JBrowse link
G Cycs cytochrome c, somatic increases expression ISO mancozeb results in increased expression of CYCS protein CTD PMID:27016407 NCBI chr 4:80,331,226...80,333,326
Ensembl chr 4:80,331,227...80,333,326 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases activity
decreases expression		 EXP
ISO		 mancozeb results in decreased activity of CYP1A1 protein
mancozeb results in decreased expression of CYP1A1 protein		 CTD PMID:1946188 PMID:31096615 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147 		JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 decreases expression ISO mancozeb results in decreased expression of CYP2B6 protein CTD PMID:31096615 NCBI chr 1:83,163,103...83,236,615
Ensembl chr 1:83,163,079...83,236,615 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 decreases expression ISO mancozeb results in decreased expression of CYP2E1 mRNA CTD PMID:31096615 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542 		JBrowse link
G Cyp3a62 cytochrome P450, family 3, subfamily a, polypeptide 62 decreases expression ISO mancozeb results in decreased expression of CYP3A4 mRNA; mancozeb results in decreased expression of CYP3A4 protein CTD PMID:31096615 NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397 		JBrowse link
G Ddit4 DNA-damage-inducible transcript 4 increases expression EXP mancozeb results in increased expression of DDIT4 protein CTD PMID:24764117 NCBI chr20:29,509,283...29,511,382
Ensembl chr20:29,509,289...29,511,382 		JBrowse link
G Elk1 ETS transcription factor ELK1 increases phosphorylation ISO mancozeb results in increased phosphorylation of ELK1 protein CTD PMID:21375462 NCBI chr  X:1,287,875...1,304,822
Ensembl chr  X:1,297,099...1,304,822 		JBrowse link
G F3 coagulation factor III, tissue factor increases expression ISO mancozeb results in increased expression of F3 protein CTD PMID:25569083 NCBI chr 2:225,310,686...225,322,281
Ensembl chr 2:225,310,624...225,322,272 		JBrowse link
G Fas Fas cell surface death receptor increases expression ISO mancozeb results in increased expression of FAS protein CTD PMID:22289270 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790 		JBrowse link
G Faslg Fas ligand increases expression ISO mancozeb results in increased expression of FASLG protein CTD PMID:22289270 NCBI chr13:79,696,811...79,717,581
Ensembl chr13:79,698,445...79,705,705 		JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha multiple interactions
increases expression		 ISO lupeol inhibits the reaction [mancozeb results in increased expression of GADD45A mRNA] CTD PMID:27235710 NCBI chr 4:97,782,512...97,784,814
Ensembl chr 4:97,782,512...97,784,842 		JBrowse link
G Got1 glutamic-oxaloacetic transaminase 1 affects activity EXP mancozeb affects the activity of GOT1 protein CTD PMID:10641187 NCBI chr 1:263,246,248...263,269,762
Ensembl chr 1:263,246,248...263,269,762 		JBrowse link
G Gpt glutamic--pyruvic transaminase affects activity EXP mancozeb affects the activity of GPT protein CTD PMID:10641187 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931 		JBrowse link
G Gpx1 glutathione peroxidase 1 decreases expression
multiple interactions		 ISO mancozeb results in decreased expression of GPX1 mRNA
Acetylcysteine inhibits the reaction [mancozeb results in decreased expression of GPX1 mRNA]		 CTD PMID:30037311 NCBI chr 8:117,117,430...117,118,528
Ensembl chr 8:117,117,430...117,118,522 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions ISO [alachlor co-treated with Captan co-treated with Diazinon co-treated with Endosulfan co-treated with mancozeb co-treated with Maneb] affects the phosphorylation of GSK3B protein CTD PMID:19883720 NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268 		JBrowse link
G Hdac3 histone deacetylase 3 decreases activity ISO mancozeb results in decreased activity of HDAC3 protein CTD PMID:21251949 NCBI chr18:31,073,057...31,094,347
Ensembl chr18:31,073,058...31,094,303 		JBrowse link
G Hdac6 histone deacetylase 6 decreases activity ISO mancozeb results in decreased activity of HDAC6 protein CTD PMID:21251949 NCBI chr  X:15,295,372...15,316,673
Ensembl chr  X:15,295,473...15,316,671 		JBrowse link
G Hnrnpm heterogeneous nuclear ribonucleoprotein M increases expression ISO mancozeb results in increased expression of HNRNPM protein CTD PMID:21375462 NCBI chr 7:18,516,253...18,554,536
Ensembl chr 7:18,516,512...18,554,227 		JBrowse link
G Ifng interferon gamma multiple interactions ISO mancozeb affects the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased secretion of TNF protein] CTD PMID:15742816 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO mancozeb inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein] CTD PMID:16112155 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726 		JBrowse link
G Il2 interleukin 2 affects expression ISO mancozeb affects the expression of IL2 protein CTD PMID:9012323 NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854 		JBrowse link
G Kb15 type II keratin Kb15 decreases expression ISO mancozeb results in decreased expression of KRT6A protein CTD PMID:21375462 NCBI chr 7:143,208,034...143,217,771
Ensembl chr 7:143,208,527...143,217,535 		JBrowse link
G Kcnq2 potassium voltage-gated channel subfamily Q member 2 increases activity EXP mancozeb results in increased activity of KCNQ2 protein CTD PMID:23542819 NCBI chr 3:176,585,897...176,645,029
Ensembl chr 3:176,589,906...176,644,951 		JBrowse link
G Kiss1 KiSS-1 metastasis-suppressor affects expression EXP mancozeb affects the expression of KISS1 mRNA CTD PMID:23660487 NCBI chr13:50,529,506...50,537,603
Ensembl chr13:50,529,510...50,535,389 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [mancozeb results in increased activity of MAPK1 protein]; mancozeb results in increased localization of and results in increased activity of MAPK1 protein CTD PMID:21375462 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [mancozeb results in increased activity of MAPK3 protein]; mancozeb results in increased localization of and results in increased activity of MAPK3 protein CTD PMID:21375462 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975 		JBrowse link
G Mdm2 MDM2 proto-oncogene multiple interactions
increases expression		 ISO lupeol inhibits the reaction [mancozeb results in increased expression of MDM2 mRNA] CTD PMID:27235710 NCBI chr 7:60,719,060...60,743,618
Ensembl chr 7:60,719,066...60,743,328 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions
increases expression
decreases expression		 ISO
EXP		 [alachlor co-treated with Captan co-treated with Diazinon co-treated with Endosulfan co-treated with mancozeb co-treated with Maneb] results in increased expression of MYC protein
mancozeb results in increased expression of MYC protein
mancozeb results in decreased expression of MYC protein
alpha-Tocopherol inhibits the reaction [mancozeb results in decreased expression of MYC protein]		 CTD PMID:16005924 PMID:19883720 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240 		JBrowse link
G Nos2 nitric oxide synthase 2 increases expression
multiple interactions		 ISO mancozeb results in increased expression of NOS2 mRNA
Acetylcysteine inhibits the reaction [mancozeb results in increased expression of NOS2 mRNA]		 CTD PMID:30037311 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190 		JBrowse link
G Nox4 NADPH oxidase 4 multiple interactions
increases expression		 ISO Acetylcysteine inhibits the reaction [mancozeb results in increased expression of NOX4 mRNA] CTD PMID:30037311 NCBI chr 1:150,796,359...150,976,186
Ensembl chr 1:150,797,084...150,976,194 		JBrowse link
G Odc1 ornithine decarboxylase 1 increases activity ISO mancozeb results in increased activity of ODC1 protein CTD PMID:1733566 NCBI chr 6:42,852,529...42,859,142
Ensembl chr 6:42,852,683...42,859,927 		JBrowse link
G Ogg1 8-oxoguanine DNA glycosylase multiple interactions
decreases expression		 ISO lupeol inhibits the reaction [mancozeb results in decreased expression of OGG1 mRNA] CTD PMID:27235710 NCBI chr 4:145,282,828...145,289,367
Ensembl chr 4:145,282,797...145,289,326 		JBrowse link
G Prdx2 peroxiredoxin 2 increases expression ISO mancozeb results in increased expression of PRDX2 protein CTD PMID:21375462 NCBI chr19:26,084,816...26,090,095
Ensembl chr19:26,084,903...26,090,094 		JBrowse link
G Prl prolactin multiple interactions ISO [mancozeb co-treated with imidacloprid] results in increased expression of PRL protein CTD PMID:24530807 NCBI chr17:39,814,236...39,824,299
Ensembl chr17:39,814,244...39,824,299 		JBrowse link
G Ptges prostaglandin E synthase increases expression
multiple interactions		 ISO mancozeb results in increased expression of PTGES mRNA
lupeol inhibits the reaction [mancozeb results in increased expression of PTGES mRNA]		 CTD PMID:27235710 NCBI chr 3:9,727,408...9,738,752
Ensembl chr 3:9,727,408...9,738,752 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression ISO mancozeb results in increased expression of PTGS2 protein CTD PMID:21375462 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335 		JBrowse link
G Ptk2b protein tyrosine kinase 2 beta multiple interactions ISO [alachlor co-treated with Captan co-treated with Diazinon co-treated with Endosulfan co-treated with mancozeb co-treated with Maneb] results in decreased expression of PTK2B protein modified form CTD PMID:19883720 NCBI chr15:42,827,306...42,947,796
Ensembl chr15:42,827,310...42,947,656 		JBrowse link
G Pvalb parvalbumin increases expression ISO mancozeb results in increased expression of PVALB protein CTD PMID:21375462 NCBI chr 7:119,428,657...119,443,674
Ensembl chr 7:119,429,019...119,441,487 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit increases phosphorylation
affects localization
multiple interactions
increases localization		 ISO mancozeb results in increased phosphorylation of RELA protein
mancozeb affects the localization of RELA protein
Acetylcysteine inhibits the reaction [mancozeb affects the localization of RELA protein]; lupeol inhibits the reaction [mancozeb affects the localization of RELA protein]; mancozeb inhibits the reaction [Lipopolysaccharides affects the localization of and results in increased activity of RELA protein]
mancozeb results in increased localization of RELA protein		 CTD PMID:16112155 PMID:21375462 PMID:22289270 PMID:27235710 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249 		JBrowse link
G S100a6 S100 calcium binding protein A6 increases expression ISO mancozeb results in increased expression of S100A6 protein CTD PMID:21375462 NCBI chr 2:190,007,013...190,008,512
Ensembl chr 2:190,007,216...190,008,511 		JBrowse link
G S100a9 S100 calcium binding protein A9 increases expression ISO mancozeb results in increased expression of S100A9 protein CTD PMID:21375462 NCBI chr 2:190,097,436...190,100,209
Ensembl chr 2:190,097,554...190,100,276 		JBrowse link
G Sirt1 sirtuin 1 decreases activity ISO mancozeb results in decreased activity of SIRT1 protein CTD PMID:21251949 NCBI chr20:26,831,971...26,851,587
Ensembl chr20:26,833,357...26,852,199 		JBrowse link
G Sirt2 sirtuin 2 decreases activity ISO mancozeb results in decreased activity of SIRT2 protein CTD PMID:21251949 NCBI chr 1:86,948,866...86,971,954
Ensembl chr 1:86,948,918...86,971,952 		JBrowse link
G Sirt3 sirtuin 3 decreases activity ISO mancozeb results in decreased activity of SIRT3 protein CTD PMID:21251949 NCBI chr 1:213,613,502...213,636,061
Ensembl chr 1:213,613,513...213,635,546 		JBrowse link
G Slc5a5 solute carrier family 5 member 5 multiple interactions ISO mancozeb inhibits the reaction [SLC5A5 protein results in increased uptake of Iodine] CTD PMID:27979590 NCBI chr16:20,297,414...20,307,401
Ensembl chr16:20,297,414...20,307,400 		JBrowse link
G Sod1 superoxide dismutase 1 decreases expression ISO mancozeb results in decreased expression of SOD1 protein CTD PMID:21375462 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862 		JBrowse link
G Tek TEK receptor tyrosine kinase increases activity ISO mancozeb results in increased activity of TEK protein CTD PMID:21251949 NCBI chr 5:113,725,717...113,852,799
Ensembl chr 5:113,725,717...113,852,799 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO mancozeb affects the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased secretion of TNF protein]
mancozeb inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; mancozeb inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; mancozeb inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of TNF protein]		 CTD PMID:15742816 PMID:15893782 PMID:16112155 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000 		JBrowse link
G Tp53 tumor protein p53 decreases expression
increases expression
multiple interactions		 ISO mancozeb results in decreased expression of TRP53 mRNA; mancozeb results in decreased expression of TRP53 protein
mancozeb results in increased expression of TP53 mRNA
lupeol inhibits the reaction [mancozeb results in increased expression of TP53 mRNA]		 CTD PMID:22369882 PMID:27235710 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449 		JBrowse link
G Tpi1 triosephosphate isomerase 1 increases expression ISO mancozeb results in increased expression of TPI1 protein CTD PMID:21375462 NCBI chr 4:157,328,375...157,331,905
Ensembl chr 4:157,328,379...157,331,905 		JBrowse link
G Tpo thyroid peroxidase decreases activity EXP mancozeb results in decreased activity of TPO protein CTD PMID:9418944 NCBI chr 6:49,020,918...49,089,855
Ensembl chr 6:49,021,044...49,089,855 		JBrowse link
G Tshb thyroid stimulating hormone subunit beta multiple interactions ISO [mancozeb co-treated with imidacloprid] results in increased expression of TSHB protein CTD PMID:24530807 NCBI chr 2:205,207,799...205,215,199
Ensembl chr 2:205,207,799...205,212,681 		JBrowse link
G Xrcc1 X-ray repair cross complementing 1 decreases expression
multiple interactions		 ISO mancozeb results in decreased expression of XRCC1 mRNA
lupeol inhibits the reaction [mancozeb results in decreased expression of XRCC1 mRNA]		 CTD PMID:27235710 NCBI chr 1:81,412,635...81,441,680
Ensembl chr 1:81,413,353...81,441,678 		JBrowse link
maneb term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acads acyl-CoA dehydrogenase short chain multiple interactions ISO [Maneb co-treated with Paraquat] results in decreased expression of ACADS mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of ACADS mRNA]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of ACADS mRNA] CTD PMID:23963992 NCBI chr12:47,254,503...47,263,747
Ensembl chr12:47,254,484...47,263,747 		JBrowse link
G Ache acetylcholinesterase decreases expression
multiple interactions		 EXP
ISO		 Maneb results in decreased expression of ACHE protein
[LRRK2 protein mutant form co-treated with Maneb co-treated with Paraquat] results in decreased expression of ACHE mRNA		 CTD PMID:3868355 PMID:23017109 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753 		JBrowse link
G Aco2 aconitase 2 multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of ACO2 mRNA CTD PMID:18386188 NCBI chr 7:123,102,493...123,145,608
Ensembl chr 7:123,102,468...123,145,635 		JBrowse link
G Adam22 ADAM metallopeptidase domain 22 multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of ADAM22 mRNA CTD PMID:22563483 NCBI chr 4:22,864,485...23,002,969
Ensembl chr 4:22,859,622...22,996,645 		JBrowse link
G Adgrb1 adhesion G protein-coupled receptor B1 multiple interactions ISO [Maneb co-treated with Paraquat] results in decreased expression of ADGRB1 mRNA CTD PMID:23017109 NCBI chr 7:115,766,484...115,828,514 JBrowse link
G Adgrg1 adhesion G protein-coupled receptor G1 multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of ADGRG1 mRNA CTD PMID:18386188 NCBI chr19:10,423,534...10,460,674
Ensembl chr19:10,423,501...10,460,674 		JBrowse link
G Adora1 adenosine A1 receptor multiple interactions ISO [SNCA protein co-treated with Maneb co-treated with Paraquat] results in decreased expression of ADORA1 mRNA CTD PMID:23017109 NCBI chr13:51,042,111...51,076,913
Ensembl chr13:51,042,248...51,076,852 		JBrowse link
G Ago3 argonaute RISC catalytic component 3 multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of AGO3 mRNA CTD PMID:22563483 NCBI chr 5:144,355,792...144,436,509
Ensembl chr 5:144,364,269...144,436,509 		JBrowse link
G Aif1 allograft inflammatory factor 1 multiple interactions ISO [Maneb co-treated with Paraquat] results in increased expression of AIF1 protein; [Paraquat co-treated with Maneb] results in increased expression of AIF1 protein; acetovanillone inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of AIF1 protein]; Glyburide inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of AIF1 protein] CTD PMID:28202386 PMID:32375810 NCBI chr20:5,161,350...5,167,176
Ensembl chr20:5,161,333...5,166,448 		JBrowse link
G Akr1b1 aldo-keto reductase family 1 member B multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of AKR1B3 mRNA CTD PMID:18386188 NCBI chr 4:61,706,866...61,720,959
Ensembl chr 4:61,706,864...61,720,956 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO [alachlor co-treated with Captan co-treated with Diazinon co-treated with Endosulfan co-treated with mancozeb co-treated with Maneb] affects the phosphorylation of AKT1 protein; [alachlor co-treated with Captan co-treated with Diazinon co-treated with Endosulfan co-treated with mancozeb co-treated with Maneb] results in decreased expression of AKT1 protein; [Maneb co-treated with Paraquat] results in decreased expression of AKT1 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of AKT1 mRNA]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of AKT1 mRNA] CTD PMID:19883720 PMID:23963992 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258 		JBrowse link
G Alas2 5'-aminolevulinate synthase 2 multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of ALAS2 mRNA CTD PMID:22563483 NCBI chr  X:23,167,576...23,187,356
Ensembl chr  X:23,167,696...23,187,341 		JBrowse link
G Aldh2 aldehyde dehydrogenase 2 family member decreases activity EXP Maneb results in decreased activity of ALDH2 protein CTD PMID:17010440 NCBI chr12:40,466,418...40,498,813
Ensembl chr12:40,466,495...40,498,752 		JBrowse link
G Aldh5a1 aldehyde dehydrogenase 5 family, member A1 decreases activity
multiple interactions		 EXP
ISO		 Maneb results in decreased activity of ALDH5A1 protein
[Maneb co-treated with Paraquat] results in decreased expression of ALDH5A1 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of ALDH5A1 mRNA]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of ALDH5A1 mRNA]		 CTD PMID:17010440 PMID:23963992 NCBI chr17:42,133,076...42,159,413
Ensembl chr17:42,133,076...42,159,413 		JBrowse link
G Aldoc aldolase, fructose-bisphosphate C multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of ALDOC mRNA CTD PMID:18386188 NCBI chr10:65,586,504...65,590,093
Ensembl chr10:65,586,504...65,590,126 		JBrowse link
G Amn amnion associated transmembrane protein multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of AMN mRNA CTD PMID:22563483 NCBI chr 6:135,724,455...135,731,896
Ensembl chr 6:135,724,455...135,731,896 		JBrowse link
G Ap3b2 adaptor related protein complex 3 subunit beta 2 multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of AP3B2 mRNA CTD PMID:18386188 NCBI chr 1:143,284,041...143,315,846
Ensembl chr 1:143,283,996...143,315,633 		JBrowse link
G Ap3d1 adaptor related protein complex 3 subunit delta 1 multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of AP3D1 mRNA CTD PMID:18386188 NCBI chr 7:11,838,639...11,873,992
Ensembl chr 7:11,838,639...11,873,984 		JBrowse link
G Apbb1 amyloid beta precursor protein binding family B member 1 multiple interactions ISO [SNCA protein co-treated with Maneb co-treated with Paraquat] results in decreased expression of APBB1 mRNA CTD PMID:23017109 NCBI chr 1:170,387,625...170,411,263
Ensembl chr 1:170,387,609...170,404,056 		JBrowse link
G Arf3 ADP-ribosylation factor 3 multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of ARF3 mRNA CTD PMID:18386188 NCBI chr 7:140,412,463...140,438,751
Ensembl chr 7:140,398,199...140,437,467 		JBrowse link
G Arg1 arginase 1 decreases expression
multiple interactions		 ISO Maneb results in decreased expression of ARG1 mRNA
[Paraquat co-treated with Maneb] results in increased expression of ARG1 mRNA		 CTD PMID:29568078 PMID:32194361 PMID:32375810 NCBI chr 1:21,525,421...21,537,872
Ensembl chr 1:21,525,421...21,537,863 		JBrowse link
G Arnt2 aryl hydrocarbon receptor nuclear translocator 2 multiple interactions ISO [Maneb co-treated with Paraquat] results in increased expression of ARNT2 mRNA CTD PMID:23017109 NCBI chr 1:146,399,217...146,556,437
Ensembl chr 1:146,399,217...146,556,171 		JBrowse link
G Ascl1 achaete-scute family bHLH transcription factor 1 multiple interactions ISO [SNCA protein co-treated with Maneb co-treated with Paraquat] results in decreased expression of ASCL1 mRNA CTD PMID:23017109 NCBI chr 7:28,038,662...28,040,504
Ensembl chr 7:28,038,662...28,040,510 		JBrowse link
G Atg12 autophagy related 12 multiple interactions ISO Maneb promotes the reaction [Paraquat results in increased expression of ATG12 protein] CTD PMID:22292029 NCBI chr18:40,721,799...40,732,143
Ensembl chr18:40,721,800...40,732,126 		JBrowse link
G Atp5f1a ATP synthase F1 subunit alpha multiple interactions ISO [Maneb co-treated with Paraquat] results in decreased expression of ATP5A1 protein; Minocycline inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of ATP5A1 protein]; tetrakis(N-methyl-4-pyridiniumyl)porphine manganese(III) complex inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of ATP5A1 protein] CTD PMID:23562983 NCBI chr18:74,156,553...74,164,490
Ensembl chr18:74,156,553...74,164,495 		JBrowse link
G Atp5mc1 ATP synthase membrane subunit c locus 1 multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of ATP5G1 mRNA CTD PMID:18386188 NCBI chr10:83,895,941...83,898,640
Ensembl chr10:83,895,947...83,898,527 		JBrowse link
G Atp6v0b ATPase H+ transporting V0 subunit B multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of ATP6V0B mRNA CTD PMID:18386188 NCBI chr 5:136,718,352...136,719,868
Ensembl chr 5:136,718,352...136,721,379 		JBrowse link
G Atp6v0c ATPase H+ transporting V0 subunit C multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of ATP6V0C mRNA CTD PMID:18386188 NCBI chr10:13,537,031...13,543,407
Ensembl chr10:13,537,033...13,542,077 		JBrowse link
G Atp6v1c1 ATPase H+ transporting V1 subunit C1 multiple interactions ISO [Maneb co-treated with Paraquat] results in decreased expression of ATP6V1C1 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of ATP6V1C1 mRNA]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of ATP6V1C1 mRNA] CTD PMID:23963992 NCBI chr 7:77,678,853...77,716,658
Ensembl chr 7:77,678,968...77,716,408 		JBrowse link
G Bad BCL2-associated agonist of cell death multiple interactions ISO [Paraquat co-treated with Maneb] results in increased phosphorylation of BAD protein CTD PMID:15824117 NCBI chr 1:222,198,516...222,207,459
Ensembl chr 1:222,198,534...222,207,453 		JBrowse link
G Bak1 BCL2-antagonist/killer 1 multiple interactions
increases expression
affects response to substance		 ISO [Maneb co-treated with Paraquat] results in increased expression of BAK1 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of BAK1 mRNA]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of BAK1 mRNA]
[Paraquat co-treated with Maneb] results in increased expression of BAK1 protein; Maneb inhibits the reaction [BAK1 protein affects the susceptibility to Paraquat]; Paraquat inhibits the reaction [BAK1 protein affects the susceptibility to Maneb]
Maneb results in increased expression of BAK1 mRNA; Maneb results in increased expression of BAK1 protein		 CTD PMID:18266926 PMID:23963992 NCBI chr20:5,609,620...5,618,899
Ensembl chr20:5,609,625...5,618,260 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression		 ISO [Paraquat co-treated with Maneb] results in increased expression of BAX protein; BAX protein affects the susceptibility to [Paraquat co-treated with Maneb]
Maneb results in increased expression of BAX protein
[Maneb co-treated with Paraquat] results in increased expression of BAX mRNA; [Paraquat co-treated with Maneb] results in increased expression of BAX protein; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of BAX mRNA]; Melatonin inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of BAX protein]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of BAX mRNA]; Silymarin inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of BAX protein]		 CTD PMID:15824117 PMID:18266926 PMID:20964710 PMID:23963992 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207 		JBrowse link
G Bbc3 Bcl-2 binding component 3 increases expression ISO Maneb results in increased expression of BBC3 protein CTD PMID:18266926 NCBI chr 1:78,261,491...78,267,802 JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
increases expression		 ISO [Maneb co-treated with Paraquat] results in decreased expression of BCL2 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of BCL2 mRNA]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of BCL2 mRNA]
Maneb results in increased expression of BCL2 mRNA; Maneb results in increased expression of BCL2 protein		 CTD PMID:18266926 PMID:23963992 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374 		JBrowse link
G Bcl2a1 BCL2-related protein A1 increases expression
multiple interactions		 ISO Maneb results in increased expression of BCL2A1 mRNA
[Paraquat co-treated with Maneb] results in increased expression of BCL2A1 protein		 CTD PMID:18266926 NCBI chr 8:96,551,424...96,559,527
Ensembl chr 8:96,551,245...96,559,483 		JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions
increases expression		 ISO [Paraquat co-treated with Maneb] results in decreased expression of BCL2L1 protein
Maneb results in increased expression of BCL2L1 mRNA		 CTD PMID:15824117 PMID:18266926 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810 		JBrowse link
G Bcl2l11 BCL2 like 11 increases expression
multiple interactions		 ISO Maneb results in increased expression of BCL2L11 protein
[Paraquat co-treated with Maneb] results in increased expression of BCL2L11 protein		 CTD PMID:18266926 NCBI chr 3:120,726,906...120,764,192
Ensembl chr 3:120,726,906...120,764,192 		JBrowse link
G Bdnf brain-derived neurotrophic factor multiple interactions ISO
EXP		 [Maneb co-treated with Paraquat] results in decreased expression of BDNF mRNA
[Paraquat co-treated with Maneb] results in decreased expression of BDNF mRNA; [Paraquat co-treated with Maneb] results in decreased expression of BDNF protein		 CTD PMID:23017109 PMID:27460631 NCBI chr 3:100,768,637...100,819,216
Ensembl chr 3:100,768,637...100,819,210 		JBrowse link
G Becn1 beclin 1 increases expression
multiple interactions		 ISO Maneb results in increased expression of BECN1 protein
[Paraquat co-treated with Maneb] results in increased expression of BECN1 protein		 CTD PMID:22292029 PMID:26884967 NCBI chr10:89,209,944...89,225,297
Ensembl chr10:89,209,940...89,225,297 		JBrowse link
G Bicd1 BICD cargo adaptor 1 multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of BICD1 mRNA CTD PMID:22563483 NCBI chr 4:184,018,845...184,167,628
Ensembl chr 4:184,019,087...184,165,540 		JBrowse link
G Bid BH3 interacting domain death agonist increases expression
multiple interactions		 ISO Maneb results in increased expression of BID protein
[Maneb co-treated with Paraquat] results in increased expression of BID protein		 CTD PMID:18266926 NCBI chr 4:153,439,812...153,465,247
Ensembl chr 4:153,442,218...153,465,203 		JBrowse link
G Bik BCL2-interacting killer increases expression
multiple interactions		 ISO Maneb results in increased expression of BIK mRNA; Maneb results in increased expression of BIK protein
[Paraquat co-treated with Maneb] results in increased expression of BIK protein		 CTD PMID:18266926 NCBI chr 7:124,390,924...124,410,449
Ensembl chr 7:124,391,432...124,410,447 		JBrowse link
G Bmp2 bone morphogenetic protein 2 multiple interactions ISO [SNCA protein co-treated with Maneb co-treated with Paraquat] results in decreased expression of BMP2 mRNA CTD PMID:23017109 NCBI chr 3:126,335,963...126,346,771
Ensembl chr 3:126,335,863...126,346,318 		JBrowse link
G Bmp4 bone morphogenetic protein 4 multiple interactions ISO [LRRK2 protein mutant form co-treated with Maneb co-treated with Paraquat] results in decreased expression of BMP4 mRNA; [SNCA protein co-treated with Maneb co-treated with Paraquat] results in decreased expression of BMP4 mRNA CTD PMID:23017109 NCBI chr15:20,776,060...20,791,013
Ensembl chr15:20,776,054...20,822,740 		JBrowse link
G Bnip3 BCL2 interacting protein 3 increases expression ISO Maneb results in increased expression of BNIP3 mRNA; Maneb results in increased expression of BNIP3 protein CTD PMID:18266926 NCBI chr 1:211,248,098...211,265,282
Ensembl chr 1:211,248,098...211,265,282 		JBrowse link
G Bnip3l BCL2 interacting protein 3 like increases expression ISO Maneb results in increased expression of BNIP3L mRNA CTD PMID:18266926 NCBI chr15:43,643,897...43,667,123
Ensembl chr15:43,643,897...43,667,029 		JBrowse link
G Brf1 BRF1, RNA polymerase III transcription initiation factor subunit multiple interactions ISO [Paraquat co-treated with Maneb] results in increased expression of BRF1 mRNA CTD PMID:18386188 NCBI chr 6:137,762,230...137,808,573
Ensembl chr 6:137,765,122...137,808,303 		JBrowse link
G Cacna1e calcium voltage-gated channel subunit alpha1 E multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of CACNA1E mRNA CTD PMID:22563483 NCBI chr13:71,899,445...72,534,992
Ensembl chr13:71,906,702...72,367,980 		JBrowse link
G Cacybp calcyclin binding protein multiple interactions ISO [Paraquat co-treated with Maneb] results in increased expression of CACYBP mRNA CTD PMID:18386188 NCBI chr13:77,948,771...77,959,089
Ensembl chr13:77,948,771...77,959,110 		JBrowse link
G Calm1 calmodulin 1 multiple interactions ISO [Maneb co-treated with Paraquat] results in increased expression of CALM1 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of CALM1 mRNA]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of CALM1 mRNA] CTD PMID:23963992 NCBI chr 6:124,217,241...124,225,292
Ensembl chr 6:124,217,241...124,225,292 		JBrowse link
G Calm2 calmodulin 2 multiple interactions ISO [Paraquat co-treated with Maneb] results in increased expression of CALM2 mRNA CTD PMID:18386188 NCBI chr 6:11,067,675...11,080,078
Ensembl chr15:65,506,874...65,507,968 		JBrowse link
G Camp cathelicidin antimicrobial peptide multiple interactions ISO
EXP		 [Paraquat co-treated with Maneb] affects the expression of CAMP mRNA
[Paraquat co-treated with Maneb] results in decreased expression of CAMP mRNA		 CTD PMID:22563483 PMID:27460631 NCBI chr 8:117,930,557...117,932,371
Ensembl chr 8:117,930,546...117,932,518 		JBrowse link
G Capn11 calpain 11 multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of CAPN11 mRNA CTD PMID:22563483 NCBI chr 9:17,728,845...17,750,357
Ensembl chr 9:17,728,816...17,750,363 		JBrowse link
G Casp1 caspase 1 multiple interactions ISO [Maneb co-treated with Paraquat] results in increased expression of CASP1 mRNA; [Paraquat co-treated with Maneb] results in increased cleavage of CASP1 protein; Glyburide inhibits the reaction [[Paraquat co-treated with Maneb] results in increased cleavage of CASP1 protein]; ITGAM protein affects the reaction [[Paraquat co-treated with Maneb] results in increased cleavage of CASP1 protein]; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of CASP1 mRNA]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of CASP1 mRNA] CTD PMID:23963992 PMID:32375810 NCBI chr 8:2,605,743...2,614,637
Ensembl chr 8:2,604,962...2,614,631 		JBrowse link
G Casp3 caspase 3 increases activity ISO Maneb results in increased activity of CASP3 protein CTD PMID:22824503 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204 		JBrowse link
G Casp7 caspase 7 increases activity ISO Maneb results in increased activity of CASP7 protein CTD PMID:22824503 NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774 		JBrowse link
G Casp8 caspase 8 increases activity ISO Maneb results in increased activity of CASP8 protein CTD PMID:22824503 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106 		JBrowse link
G Casp9 caspase 9 multiple interactions
increases activity		 ISO [Maneb co-treated with Paraquat] results in increased expression of CASP9 mRNA; [Paraquat co-treated with Maneb] results in increased expression of CASP9 protein; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of CASP9 mRNA]; Melatonin inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of CASP9 protein]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of CASP9 mRNA]; Silymarin inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of CASP9 protein]
Maneb results in increased activity of CASP9 protein		 CTD PMID:20964710 PMID:22824503 PMID:23963992 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778 		JBrowse link
G Cat catalase decreases activity
multiple interactions		 ISO
EXP		 Maneb results in decreased activity of CAT protein
[Maneb co-treated with Paraquat] results in increased expression of CAT mRNA		 CTD PMID:26210702 PMID:29859004 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058 		JBrowse link
G Ccdc88a coiled coil domain containing 88A multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of CCDC88A mRNA CTD PMID:22563483 NCBI chr14:113,771,093...113,936,376
Ensembl chr14:113,867,209...113,932,263 		JBrowse link
G Ccl19 C-C motif chemokine ligand 19 multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of CCL19 mRNA CTD PMID:22563483 NCBI chr 5:58,181,025...58,182,969
Ensembl chr 5:58,181,026...58,183,017 		JBrowse link
G Ccl21 C-C motif chemokine ligand 21 multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of CCL21 mRNA; [Paraquat co-treated with Maneb] affects the expression of CCL21A mRNA CTD PMID:22563483 NCBI chr 5:58,197,678...58,198,782
Ensembl chr 5:58,197,680...58,198,782 		JBrowse link
G Ccnd1 cyclin D1 multiple interactions ISO
EXP		 [alachlor co-treated with Captan co-treated with Diazinon co-treated with Endosulfan co-treated with mancozeb co-treated with Maneb] results in increased expression of CCND1 protein
[Maneb co-treated with Paraquat] results in decreased expression of CCND1 mRNA		 CTD PMID:19883720 PMID:29859004 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325 		JBrowse link
G Ccnd2 cyclin D2 multiple interactions EXP [Maneb co-treated with Paraquat] results in decreased expression of CCND2 mRNA CTD PMID:29859004 NCBI chr 4:159,674,885...159,697,207
Ensembl chr 4:159,674,885...159,697,207 		JBrowse link
G Cd34 CD34 molecule increases expression EXP Maneb results in increased expression of CD34 CTD PMID:25803990 NCBI chr13:113,691,842...113,711,259
Ensembl chr13:113,691,932...113,711,647 		JBrowse link
G Cd68 Cd68 molecule multiple interactions ISO [Paraquat co-treated with Maneb] results in increased expression of CD68 mRNA; Poloxamer inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of CD68 mRNA] CTD PMID:32169474 NCBI chr10:56,268,726...56,270,605
Ensembl chr10:56,268,720...56,270,640 		JBrowse link
G Cdhr4 cadherin-related family member 4 multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of CDHR4 mRNA CTD PMID:22563483 NCBI chr 8:116,771,377...116,779,242 JBrowse link
G Cdipt CDP-diacylglycerol--inositol 3-phosphatidyltransferase multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of CDIPT mRNA CTD PMID:18386188 NCBI chr 1:198,409,186...198,413,497
Ensembl chr 1:198,409,360...198,413,497 		JBrowse link
G Cdk2 cyclin dependent kinase 2 multiple interactions ISO [Maneb co-treated with Paraquat] results in decreased expression of CDK2 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of CDK2 mRNA]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of CDK2 mRNA] CTD PMID:23963992 NCBI chr 7:3,124,953...3,132,533
Ensembl chr 7:3,124,954...3,132,457 		JBrowse link
G Cdk5r1 cyclin-dependent kinase 5 regulatory subunit 1 multiple interactions ISO [LRRK2 protein mutant form co-treated with Maneb co-treated with Paraquat] results in decreased expression of CDK5R1 mRNA CTD PMID:23017109 NCBI chr10:67,862,054...67,863,255
Ensembl chr10:67,862,054...67,863,255 		JBrowse link
G Cdk5rap1 CDK5 regulatory subunit associated protein 1 multiple interactions ISO [LRRK2 protein mutant form co-treated with Maneb co-treated with Paraquat] results in decreased expression of CDK5RAP1 mRNA CTD PMID:23017109 NCBI chr 3:149,835,953...149,870,429
Ensembl chr 3:149,703,848...149,870,413 		JBrowse link
G Cdk5rap2 CDK5 regulatory subunit associated protein 2 multiple interactions ISO [Maneb co-treated with Paraquat] results in increased expression of CDK5RAP2 mRNA; LRRK2 protein mutant form inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of CDK5RAP2 mRNA]; SNCA protein inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of CDK5RAP2 mRNA] CTD PMID:23017109 NCBI chr 5:86,387,238...86,554,108
Ensembl chr 5:86,387,078...86,554,102 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions ISO [Maneb co-treated with Paraquat] results in increased expression of CDKN1A mRNA; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of CDKN1A mRNA] CTD PMID:23963992 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864 		JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A multiple interactions
increases expression		 EXP [Maneb co-treated with Paraquat] results in increased expression of CDKN2A mRNA
Maneb results in increased expression of CDKN2A mRNA		 CTD PMID:29859004 NCBI chr 5:107,823,323...107,832,405
Ensembl chr 5:107,823,330...107,841,175 		JBrowse link
G Cebpd CCAAT/enhancer binding protein delta multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of CEBPD mRNA CTD PMID:22563483 NCBI chr11:89,008,008...89,009,146
Ensembl chr11:89,008,008...89,009,146 		JBrowse link
G Cep290 centrosomal protein 290 multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of CEP290 mRNA CTD PMID:22563483 NCBI chr 7:40,217,269...40,306,327
Ensembl chr 7:40,217,269...40,306,327 		JBrowse link
G Chrm2 cholinergic receptor, muscarinic 2 multiple interactions ISO [LRRK2 protein mutant form co-treated with Maneb co-treated with Paraquat] results in decreased expression of CHRM2 mRNA CTD PMID:23017109 NCBI chr 4:64,089,028...64,091,090
Ensembl chr 4:64,088,900...64,091,090 		JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex multiple interactions ISO [Paraquat co-treated with Maneb] results in increased phosphorylation of CHUK protein; Taurine inhibits the reaction [[Paraquat co-treated with Maneb] results in increased phosphorylation of CHUK protein] CTD PMID:29568078 NCBI chr 1:263,848,829...263,884,354
Ensembl chr 1:263,848,884...263,885,169 		JBrowse link
G Cirbp cold inducible RNA binding protein multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of CIRBP mRNA CTD PMID:18386188 NCBI chr 7:12,400,066...12,405,054
Ensembl chr 7:12,401,207...12,405,022 		JBrowse link
G Clca1 chloride channel accessory 1 multiple interactions ISO [Maneb co-treated with Paraquat] results in decreased expression of CLCA1 mRNA; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of CLCA1 mRNA] CTD PMID:23963992 NCBI chr 2:250,897,980...250,923,711
Ensembl chr 2:250,897,969...250,923,744 		JBrowse link
G Clu clusterin multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of CLU mRNA CTD PMID:18386188 NCBI chr15:42,626,612...42,665,858
Ensembl chr15:42,640,146...42,665,857 		JBrowse link
G Cope COPI coat complex subunit epsilon multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of COPE mRNA CTD PMID:18386188 NCBI chr16:20,863,141...20,873,516
Ensembl chr16:20,863,141...20,873,521 		JBrowse link
G Cox5a cytochrome c oxidase subunit 5A multiple interactions ISO [Maneb co-treated with Paraquat] results in decreased expression of COX5A protein; Levodopa inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of COX5A protein]; Minocycline inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of COX5A protein]; tetrakis(N-methyl-4-pyridiniumyl)porphine manganese(III) complex inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of COX5A protein] CTD PMID:23562983 NCBI chr 8:62,298,358...62,309,765
Ensembl chr 8:62,298,358...62,309,765 		JBrowse link
G Cox6a1 cytochrome c oxidase subunit 6A1 multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of COX6A1 mRNA CTD PMID:18386188 NCBI chr12:47,024,442...47,027,495
Ensembl chr12:47,024,442...47,027,495 		JBrowse link
G Cox6b1 cytochrome c oxidase subunit 6B1 multiple interactions ISO [Maneb co-treated with Paraquat] results in decreased expression of COX6B1 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of COX6B1 mRNA]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of COX6B1 mRNA] CTD PMID:23963992 NCBI chr 1:89,075,987...89,084,834
Ensembl chr 1:89,075,975...89,084,859
Ensembl chr 2:89,075,975...89,084,859 		JBrowse link
G Cox7a2 cytochrome c oxidase subunit 7A2 multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of COX7A2 mRNA CTD PMID:18386188 NCBI chr 8:87,209,529...87,213,627
Ensembl chr 8:87,209,530...87,213,627 		JBrowse link
G Cox7a2l cytochrome c oxidase subunit 7A2 like multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of COX7A2L mRNA CTD PMID:18386188 NCBI chr 6:6,695,807...6,709,790
Ensembl chr 6:6,695,827...6,709,783 		JBrowse link
G Cplx1 complexin 1 multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of CPLX1 mRNA; [Paraquat co-treated with Maneb] results in decreased expression of CPLX1 protein CTD PMID:17532186 NCBI chr14:2,194,895...2,226,610
Ensembl chr14:2,194,933...2,226,598 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions ISO
EXP		 [Maneb co-treated with Paraquat] results in decreased expression of CREB1 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of CREB1 mRNA]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of CREB1 mRNA]
[Paraquat co-treated with Maneb] results in decreased expression of CREB1 mRNA; [Paraquat co-treated with Maneb] results in decreased expression of CREB1 protein; [Paraquat co-treated with Maneb] results in decreased expression of CREB1 protein modified form		 CTD PMID:23963992 PMID:27460631 NCBI chr 9:71,229,753...71,298,994
Ensembl chr 9:71,230,108...71,293,435 		JBrowse link
G Crip2 cysteine-rich protein 2 multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of CRIP2 mRNA CTD PMID:18386188 NCBI chr 6:137,953,545...137,958,491
Ensembl chr 6:137,953,545...137,958,490 		JBrowse link
G Crlf2 cytokine receptor-like factor 2 multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of CRLF2 mRNA CTD PMID:22563483 NCBI chr14:1,456,843...1,461,543
Ensembl chr14:1,456,844...1,461,543 		JBrowse link
G Crot carnitine O-octanoyltransferase multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of CROT mRNA CTD PMID:18386188 NCBI chr 4:22,079,837...22,116,265
Ensembl chr 4:22,081,604...22,116,265 		JBrowse link
G Csf1r colony stimulating factor 1 receptor multiple interactions ISO [Paraquat co-treated with Maneb] results in increased expression of CSF1R mRNA; Poloxamer inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of CSF1R mRNA] CTD PMID:32169474 NCBI chr18:56,414,493...56,458,300
Ensembl chr18:56,414,488...56,458,300 		JBrowse link
G Csf2ra colony stimulating factor 2 receptor subunit alpha multiple interactions ISO [Paraquat co-treated with Maneb] results in increased expression of CSF2RA mRNA; Poloxamer inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of CSF2RA mRNA] CTD PMID:32169474 NCBI chr14:1,462,292...1,467,264
Ensembl chr14:1,462,358...1,467,264 		JBrowse link
G Ctsl cathepsin L multiple interactions ISO [Maneb co-treated with Paraquat] results in increased expression of CTSL mRNA; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of CTSL mRNA] CTD PMID:23963992 NCBI chr17:1,873,105...1,879,266
Ensembl chr17:1,872,848...1,879,279 		JBrowse link
G Cybb cytochrome b-245 beta chain multiple interactions ISO [Paraquat co-treated with Maneb] results in increased expression of NOX2 mRNA; acetovanillone inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of NOX2 mRNA]; diphenyleneiodonium inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of NOX2 mRNA]
[Paraquat co-treated with Maneb] results in increased expression of CYBB protein; Glyburide inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of CYBB protein]; Taurine inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of CYBB protein]		 CTD PMID:29568078 PMID:30797899 PMID:32375810 NCBI chr  X:14,578,330...14,610,049
Ensembl chr  X:14,578,264...14,612,547 		JBrowse link
G Cyc1 cytochrome c-1 multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of CYC1 mRNA CTD PMID:18386188 NCBI chr 7:117,409,576...117,411,953
Ensembl chr 7:117,409,576...117,411,953 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases activity
decreases expression
increases expression		 EXP
ISO		 Maneb results in increased activity of CYP1A1 protein
Maneb results in decreased expression of CYP1A1 mRNA
Maneb results in increased expression of CYP1A1 mRNA; Maneb results in increased expression of CYP1A1 protein		 CTD PMID:20888808 PMID:32194361 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions EXP [Paraquat co-treated with Maneb] results in increased expression of and results in increased activity of CYP1A2 protein; [Paraquat co-treated with Maneb] results in increased expression of CYP1A2 mRNA; Acetylcysteine inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of and results in increased activity of CYP1A2 protein]; Acetylcysteine inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of CYP1A2 mRNA]; Silymarin inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of and results in increased activity of CYP1A2 protein]; Silymarin inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of CYP1A2 mRNA] CTD PMID:23159886 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301 		JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 decreases expression ISO Maneb results in decreased expression of CYP2C19 protein CTD PMID:32194361 NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007 		JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 multiple interactions
decreases expression		 ISO Ketoconazole inhibits the reaction [Maneb results in decreased expression of CYP2D22 protein] CTD PMID:22334051 NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 decreases activity
increases expression
multiple interactions
increases activity		 EXP
ISO		 Maneb results in decreased activity of CYP2E1 protein
Maneb results in increased expression of CYP2E1 mRNA; Maneb results in increased expression of CYP2E1 protein
[Maneb co-treated with Paraquat] results in increased expression of and results in increased activity of CYP2E1 protein; [Maneb co-treated with Paraquat] results in increased expression of CYP2E1 mRNA; Acetylcysteine inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of and results in increased activity of CYP2E1 protein]; Acetylcysteine inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of CYP2E1 mRNA]; Acetylcysteine inhibits the reaction [Maneb results in increased expression of and results in increased activity of CYP2E1 protein]; Acetylcysteine inhibits the reaction [Maneb results in increased expression of CYP2E1 mRNA]; Maneb results in increased expression of and results in increased activity of CYP2E1 protein; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of and results in increased activity of CYP2E1 protein]; Silymarin inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of CYP2E1 mRNA]; Silymarin inhibits the reaction [Maneb results in increased expression of and results in increased activity of CYP2E1 protein]; Silymarin inhibits the reaction [Maneb results in increased expression of CYP2E1 mRNA]
Maneb results in increased activity of CYP2E1 protein
[Maneb co-treated with Paraquat] results in increased expression of CYP2E1 mRNA; [Paraquat co-treated with Maneb] results in increased activity of CYP2E1 protein; [Paraquat co-treated with Maneb] results in increased expression of CYP2E1 mRNA; Melatonin inhibits the reaction [[Paraquat co-treated with Maneb] results in increased activity of CYP2E1 protein]; Melatonin inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of CYP2E1 mRNA]; Silymarin inhibits the reaction [[Paraquat co-treated with Maneb] results in increased activity of CYP2E1 protein]; Silymarin inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of CYP2E1 mRNA]		 CTD PMID:11043497 PMID:16510128 PMID:20888808 PMID:20964710 PMID:23159886 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542 		JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 decreases expression ISO Maneb results in decreased expression of CYP7A1 mRNA CTD PMID:32194361 NCBI chr 5:19,358,734...19,368,431
Ensembl chr 5:19,358,734...19,368,431 		JBrowse link
G Dap3 death associated protein 3 multiple interactions ISO [Maneb co-treated with Paraquat] results in increased expression of DAP3 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of DAP3 mRNA] CTD PMID:23963992 NCBI chr 2:188,225,607...188,255,324
Ensembl chr 2:188,225,613...188,252,725 		JBrowse link
G Dbi diazepam binding inhibitor, acyl-CoA binding protein multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of DBI mRNA CTD PMID:18386188 NCBI chr13:36,147,667...36,156,076
Ensembl chr13:36,117,119...36,174,908 		JBrowse link
G Ddit4 DNA-damage-inducible transcript 4 increases expression EXP Maneb results in increased expression of DDIT4 protein CTD PMID:24764117 NCBI chr20:29,509,283...29,511,382
Ensembl chr20:29,509,289...29,511,382 		JBrowse link
G Ddx5 DEAD-box helicase 5 multiple interactions ISO [Paraquat co-treated with Maneb] results in increased expression of DDX5 mRNA CTD PMID:18386188 NCBI chr10:94,979,759...94,988,461
Ensembl chr10:94,980,928...94,988,461 		JBrowse link
G Dgki diacylglycerol kinase, iota multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of DGKI mRNA CTD PMID:22563483 NCBI chr 4:64,365,115...64,831,473
Ensembl chr 4:64,374,342...64,831,473 		JBrowse link
G Dio1 iodothyronine deiodinase 1 decreases activity ISO Maneb results in decreased activity of DIO1 protein CTD PMID:29228274 NCBI chr 5:126,894,837...126,911,532
Ensembl chr 5:126,895,286...126,911,520 		JBrowse link
G Dip2b disco-interacting protein 2 homolog B multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of DIP2B mRNA CTD PMID:22563483 NCBI chr 7:141,702,034...141,878,945
Ensembl chr 7:141,702,038...141,879,951 		JBrowse link
G Dll1 delta like canonical Notch ligand 1 multiple interactions ISO [SNCA protein co-treated with Maneb co-treated with Paraquat] results in decreased expression of DLL1 mRNA CTD PMID:23017109 NCBI chr 1:57,318,621...57,326,732
Ensembl chr 1:57,318,708...57,327,379 		JBrowse link
G Dlst dihydrolipoamide S-succinyltransferase multiple interactions ISO [Maneb co-treated with Paraquat] results in increased expression of DLST protein; Minocycline inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of DLST protein]; tetrakis(N-methyl-4-pyridiniumyl)porphine manganese(III) complex inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of DLST protein] CTD PMID:23562983 NCBI chr 6:108,936,534...108,961,322
Ensembl chr 6:108,936,664...108,959,803 		JBrowse link
G Dmrta2 DMRT-like family A2 multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of DMRTA2 mRNA CTD PMID:22563483 NCBI chr 5:129,754,295...129,760,045
Ensembl chr 5:129,756,149...129,758,986 		JBrowse link
G Dnajb6 DnaJ heat shock protein family (Hsp40) member B6 multiple interactions ISO [Paraquat co-treated with Maneb] results in increased expression of DNAJB6 mRNA CTD PMID:18386188 NCBI chr 4:2,711,329...2,774,969
Ensembl chr 4:2,711,385...2,774,890 		JBrowse link
G Dnm2 dynamin 2 multiple interactions ISO [Maneb co-treated with Paraquat] results in decreased expression of DNM2 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of DNM2 mRNA] CTD PMID:23963992 NCBI chr 8:22,458,869...22,540,649
Ensembl chr 8:22,458,899...22,540,524 		JBrowse link
G Drd2 dopamine receptor D2 multiple interactions ISO [SNCA protein co-treated with Maneb co-treated with Paraquat] results in decreased expression of DRD2 mRNA CTD PMID:23017109 NCBI chr 8:53,678,777...53,743,643
Ensembl chr 8:53,678,777...53,743,642 		JBrowse link
G Drd4 dopamine receptor D4 multiple interactions ISO [Paraquat co-treated with Maneb] results in increased expression of DRD4 protein CTD PMID:22563483 NCBI chr 1:214,278,296...214,282,818
Ensembl chr 1:214,278,296...214,281,483 		JBrowse link
G Drd5 dopamine receptor D5 multiple interactions ISO [SNCA protein co-treated with Maneb co-treated with Paraquat] results in decreased expression of DRD5 mRNA CTD PMID:23017109 NCBI chr14:77,220,579...77,222,006
Ensembl chr14:77,220,579...77,222,006 		JBrowse link
G E2f1 E2F transcription factor 1 multiple interactions ISO [Maneb co-treated with Paraquat] results in increased expression of E2F1 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of E2F1 mRNA] CTD PMID:23963992 NCBI chr 3:150,062,895...150,073,721
Ensembl chr 3:150,047,826...150,073,721 		JBrowse link
G Eef1a1 eukaryotic translation elongation factor 1 alpha 1 multiple interactions ISO [Paraquat co-treated with Maneb] results in increased expression of EEF1A1 mRNA CTD PMID:18386188 NCBI chr 8:85,838,594...85,841,816
Ensembl chr 8:85,838,869...85,840,818 		JBrowse link
G Eef1g eukaryotic translation elongation factor 1 gamma multiple interactions ISO [Maneb co-treated with Paraquat] results in decreased expression of EEF1G mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of EEF1G mRNA]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of EEF1G mRNA] CTD PMID:23963992 NCBI chr 1:225,163,391...225,173,997
Ensembl chr 1:225,163,391...225,173,995 		JBrowse link
G Efnb1 ephrin B1 multiple interactions ISO [LRRK2 protein mutant form co-treated with Maneb co-treated with Paraquat] results in decreased expression of EFNB1 mRNA CTD PMID:23017109 NCBI chr  X:68,891,227...68,904,034
Ensembl chr  X:68,891,227...68,904,038 		JBrowse link
G Egr4 early growth response 4 multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of EGR4 mRNA CTD PMID:22563483 NCBI chr 4:117,293,620...117,296,082
Ensembl chr 4:117,293,620...117,296,082 		JBrowse link
G Eif4g2 eukaryotic translation initiation factor 4, gamma 2 multiple interactions ISO [Maneb co-treated with Paraquat] results in decreased expression of EIF4G2 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of EIF4G2 mRNA] CTD PMID:23963992 NCBI chr 1:175,883,362...175,895,510
Ensembl chr 1:175,883,363...175,895,510 		JBrowse link
G Elk1 ETS transcription factor ELK1 multiple interactions ISO [Maneb co-treated with Paraquat] results in decreased expression of ELK1 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of ELK1 mRNA] CTD PMID:23963992 NCBI chr  X:1,287,875...1,304,822
Ensembl chr  X:1,297,099...1,304,822 		JBrowse link
G Eno1 enolase 1 multiple interactions ISO [Maneb co-treated with Paraquat] results in increased expression of ENO1 protein; [Paraquat co-treated with Maneb] results in decreased expression of ENO1 mRNA; [Paraquat co-treated with Maneb] results in decreased expression of ENO1 protein; Minocycline inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of ENO1 protein] CTD PMID:17532186 PMID:18386188 PMID:23562983 NCBI chr 5:167,288,223...167,299,610
Ensembl chr 5:167,288,223...167,299,609 		JBrowse link
G Eno2 enolase 2 multiple interactions ISO [Maneb co-treated with Paraquat] results in increased expression of ENO2 protein CTD PMID:23562983 NCBI chr 4:157,285,192...157,294,090
Ensembl chr 4:157,285,179...157,294,047 		JBrowse link
G Etl4 enhancer trap locus 4 multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of ETL4 mRNA CTD PMID:22563483 NCBI chr17:87,173,265...87,681,268
Ensembl chr17:87,274,944...87,681,317 		JBrowse link
G Fas Fas cell surface death receptor multiple interactions ISO [Maneb co-treated with Paraquat] results in increased expression of FAS mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of FAS mRNA]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of FAS mRNA] CTD PMID:23963992 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790 		JBrowse link
G Fez1 fasciculation and elongation protein zeta 1 multiple interactions ISO [LRRK2 protein mutant form co-treated with Maneb co-treated with Paraquat] results in decreased expression of FEZ1 mRNA CTD PMID:23017109 NCBI chr 8:39,305,128...39,350,270
Ensembl chr 8:39,305,128...39,350,270 		JBrowse link
G Fgfr3 fibroblast growth factor receptor 3 multiple interactions ISO [Maneb co-treated with Paraquat] results in increased expression of FGFR3 mRNA; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of FGFR3 mRNA] CTD PMID:23963992 NCBI chr14:82,272,322...82,287,739
Ensembl chr14:82,273,070...82,287,706 		JBrowse link
G Fkbp4 FKBP prolyl isomerase 4 multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of FKBP4 mRNA CTD PMID:18386188 NCBI chr 4:161,748,993...161,757,447
Ensembl chr 4:161,748,993...161,757,447 		JBrowse link
G Fkbp5 FKBP prolyl isomerase 5 multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of FKBP5 mRNA CTD PMID:18386188 NCBI chr20:7,976,704...8,097,290
Ensembl chr20:7,976,713...8,019,020 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO
EXP		 [Maneb co-treated with Paraquat] results in increased expression of FOS mRNA; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of FOS mRNA]
[Paraquat co-treated with Maneb] results in decreased expression of FOS mRNA; [Paraquat co-treated with Maneb] results in decreased expression of FOS protein		 CTD PMID:23963992 PMID:27460631 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299 		JBrowse link
G Fxyd6 FXYD domain-containing ion transport regulator 6 multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of FXYD6 mRNA CTD PMID:18386188 NCBI chr 8:49,676,520...49,703,419
Ensembl chr 8:49,676,540...49,703,419 		JBrowse link
G G6pc1 glucose-6-phosphatase catalytic subunit 1 decreases expression ISO Maneb results in decreased expression of G6PC1 mRNA CTD PMID:32194361 NCBI chr10:89,286,009...89,296,213
Ensembl chr10:89,285,855...89,296,213 		JBrowse link
G Gabra6 gamma-aminobutyric acid type A receptor subunit alpha6 multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of GABRA6 mRNA CTD PMID:22563483 NCBI chr10:27,847,447...27,862,896
Ensembl chr10:27,847,439...27,862,868 		JBrowse link
G Gas5 growth arrest specific 5 multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of GAS5 mRNA CTD PMID:18386188 NCBI chr13:78,852,523...78,855,844 JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression
increases activity		 ISO
EXP		 [Maneb results in increased expression of NFE2L2 protein] which results in increased expression of GCLC mRNA
Maneb results in increased activity of GCLC protein		 CTD PMID:15527874 PMID:21402726 NCBI chr 8:85,059,051...85,097,471
Ensembl chr 8:85,059,051...85,097,468 		JBrowse link
G Gfap glial fibrillary acidic protein multiple interactions ISO [Paraquat co-treated with Maneb] results in increased expression of GFAP protein; acetovanillone inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of GFAP protein] CTD PMID:30797899 NCBI chr10:90,990,762...90,999,435
Ensembl chr10:90,990,762...90,999,506 		JBrowse link
G Gh1 growth hormone 1 multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of GH mRNA CTD PMID:22563483 NCBI chr10:94,486,204...94,488,181
Ensembl chr10:94,486,205...94,488,180 		JBrowse link
G Gm2a GM2 ganglioside activator multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of GM2A mRNA CTD PMID:18386188 NCBI chr10:40,438,394...40,450,927
Ensembl chr10:40,438,356...40,450,930 		JBrowse link
G Gmfb glia maturation factor, beta multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of GMFB mRNA; [Paraquat co-treated with Maneb] results in decreased expression of GMFB protein CTD PMID:17532186 NCBI chr15:23,597,846...23,611,541
Ensembl chr15:23,601,368...23,606,634 		JBrowse link
G Gng5 G protein subunit gamma 5 multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of GNG5 mRNA CTD PMID:18386188 NCBI chr 2:252,359,976...252,368,473
Ensembl chr 2:252,359,976...252,368,473 		JBrowse link
G Gngt2 G protein subunit gamma transducin 2 multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of GNGT2 mRNA CTD PMID:22563483 NCBI chr10:83,654,321...83,658,601
Ensembl chr10:83,655,460...83,658,589 		JBrowse link
G Gpr27 G protein-coupled receptor 27 multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of GPR27 mRNA CTD PMID:22563483 NCBI chr 4:132,137,793...132,138,926
Ensembl chr 4:132,137,793...132,138,926 		JBrowse link
G Gpx1 glutathione peroxidase 1 multiple interactions
decreases expression		 ISO
EXP		 GPX1 protein results in decreased susceptibility to [Paraquat co-treated with Maneb]
[Maneb co-treated with Paraquat] results in increased expression of GPX1 mRNA
Maneb results in decreased expression of GPX1 mRNA		 CTD PMID:15824117 PMID:26210702 PMID:29859004 NCBI chr 8:117,117,430...117,118,528
Ensembl chr 8:117,117,430...117,118,522 		JBrowse link
G Gpx4 glutathione peroxidase 4 increases expression
multiple interactions		 ISO Maneb results in increased expression of GPX4 mRNA
[Paraquat co-treated with Maneb] results in decreased expression of GPX4 protein
[Paraquat co-treated with Maneb] results in decreased expression of GPX4 protein; acetovanillone inhibits the reaction [[Paraquat co-treated with Maneb] results in decreased expression of GPX4 protein]; NFE2L2 gene mutant form inhibits the reaction [Maneb results in increased expression of GPX4 mRNA]		 CTD PMID:23764462 PMID:30797899 NCBI chr 7:12,516,357...12,519,154
Ensembl chr 7:12,516,352...12,519,154 		JBrowse link
G Grb2 growth factor receptor bound protein 2 multiple interactions ISO [Maneb co-treated with Paraquat] results in decreased expression of GRB2 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of GRB2 mRNA]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of GRB2 mRNA] CTD PMID:23963992 NCBI chr10:104,193,953...104,263,071
Ensembl chr10:104,193,955...104,263,071 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions ISO [alachlor co-treated with Captan co-treated with Diazinon co-treated with Endosulfan co-treated with mancozeb co-treated with Maneb] affects the phosphorylation of GSK3B protein CTD PMID:19883720 NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268 		JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions EXP
ISO		 [Acetylcysteine co-treated with Paraquat co-treated with Maneb] results in increased activity of GSR protein; [Silymarin co-treated with Maneb] results in increased activity of GSR protein; [Silymarin co-treated with Paraquat co-treated with Maneb] results in increased activity of GSR protein
[NFE2L2 gene mutant form results in increased susceptibility to Maneb] which results in decreased expression of GSR protein		 CTD PMID:23159886 PMID:23764462 NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361 		JBrowse link
G Gsta2 glutathione S-transferase alpha 2 increases expression EXP Maneb results in increased expression of GSTA3 mRNA CTD PMID:20888808 NCBI chr 8:85,640,081...85,645,621 JBrowse link
G Gsta4 glutathione S-transferase alpha 4 multiple interactions
increases activity
increases expression		 EXP [Paraquat co-treated with Maneb] results in increased expression of and results in increased activity of GSTA4 protein; [Paraquat co-treated with Maneb] results in increased expression of GSTA4 mRNA; Acetylcysteine promotes the reaction [[Paraquat co-treated with Maneb] results in increased expression of and results in increased activity of GSTA4 protein]; Acetylcysteine promotes the reaction [[Paraquat co-treated with Maneb] results in increased expression of GSTA4 mRNA]; Acetylcysteine promotes the reaction [Maneb results in increased expression of and results in increased activity of GSTA4 protein]; Acetylcysteine promotes the reaction [Maneb results in increased expression of GSTA4 mRNA]; Maneb results in increased expression of and results in increased activity of GSTA4 protein; Silymarin promotes the reaction [[Paraquat co-treated with Maneb] results in increased expression of and results in increased activity of GSTA4 protein]; Silymarin promotes the reaction [[Paraquat co-treated with Maneb] results in increased expression of GSTA4 mRNA]; Silymarin promotes the reaction [Maneb results in increased expression of and results in increased activity of GSTA4 protein]; Silymarin promotes the reaction [Maneb results in increased expression of GSTA4 mRNA]
Maneb results in increased activity of GSTA4 protein
Maneb results in increased expression of GSTA4 mRNA; Maneb results in increased expression of GSTA4 protein		 CTD PMID:20888808 PMID:23159886 NCBI chr 8:85,497,557...85,514,732
Ensembl chr 8:85,497,557...85,518,879 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions ISO [Maneb co-treated with Paraquat] results in decreased expression of GSTP1 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of GSTP1 mRNA]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of GSTP1 mRNA] CTD PMID:23963992 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147 		JBrowse link
G Guk1 guanylate kinase 1 multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of GUK1 mRNA CTD PMID:18386188 NCBI chr10:45,535,617...45,552,455
Ensembl chr10:45,535,627...45,543,897 		JBrowse link
G H2ac20 H2A clustered histone 20 multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of H2AC20 mRNA CTD PMID:22563483 NCBI chr 2:198,360,271...198,360,735
Ensembl chr 2:198,360,301...198,360,678 		JBrowse link
G H2bu1 H2B.U histone 1 multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of H2BC9 mRNA CTD PMID:22563483 NCBI chr10:45,296,638...45,297,385
Ensembl chr10:45,296,638...45,297,385 		JBrowse link
G Hba-a1 hemoglobin alpha, adult chain 1 multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of HBA-A1 mRNA CTD PMID:18386188 NCBI chr10:15,602,794...15,603,649
Ensembl chr10:15,602,794...15,603,649 		JBrowse link
G Hdac3 histone deacetylase 3 decreases activity ISO Maneb results in decreased activity of HDAC3 protein CTD PMID:21251949 NCBI chr18:31,073,057...31,094,347
Ensembl chr18:31,073,058...31,094,303 		JBrowse link
G Hdac6 histone deacetylase 6 decreases activity ISO Maneb results in decreased activity of HDAC6 protein CTD PMID:21251949 NCBI chr  X:15,295,372...15,316,673
Ensembl chr  X:15,295,473...15,316,671 		JBrowse link
G Hes3 hes family bHLH transcription factor 3 multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of HES3 mRNA CTD PMID:22563483 NCBI chr 5:169,463,196...169,469,795
Ensembl chr 5:169,464,989...169,467,153 		JBrowse link
G Hey2 hes-related family bHLH transcription factor with YRPW motif 2 multiple interactions ISO [LRRK2 protein mutant form co-treated with Maneb co-treated with Paraquat] results in decreased expression of HEY2 mRNA CTD PMID:23017109 NCBI chr 1:29,191,170...29,201,257
Ensembl chr 1:29,191,192...29,201,531 		JBrowse link
G Heyl hes-related family bHLH transcription factor with YRPW motif-like multiple interactions ISO [SNCA protein co-treated with Maneb co-treated with Paraquat] results in decreased expression of HEYL mRNA CTD PMID:23017109 NCBI chr 5:140,923,914...140,940,905
Ensembl chr 5:140,923,914...140,940,905 		JBrowse link
G Hist3h2a histone cluster 3, H2a multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of H2AC6 mRNA CTD PMID:22563483 NCBI chr10:45,297,603...45,299,155 JBrowse link
G Hk1 hexokinase 1 multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of HK1 mRNA CTD PMID:18386188 NCBI chr20:31,911,460...31,979,780
Ensembl chr20:31,912,262...31,956,649 		JBrowse link
G Hmga2 high mobility group AT-hook 2 multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of HMGA2 mRNA CTD PMID:18386188 NCBI chr 7:65,159,944...65,275,408
Ensembl chr 7:65,159,944...65,275,408 		JBrowse link
G Hmgn5 high mobility group nucleosome binding domain 5 multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of HMGN5 mRNA CTD PMID:22563483 NCBI chr  X:80,134,557...80,142,902
Ensembl chr  X:80,134,557...80,142,902 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression
multiple interactions		 EXP
ISO		 Maneb results in increased expression of HMOX1 protein
[NFE2L2 gene mutant form results in increased susceptibility to Maneb] which results in decreased expression of HMOX1 protein		 CTD PMID:15527874 PMID:23764462 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456 		JBrowse link
G Hnrnpk heterogeneous nuclear ribonucleoprotein K multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of HNRNPK mRNA CTD PMID:18386188 NCBI chr17:6,664,730...6,676,753
Ensembl chr17:6,665,659...6,676,654 		JBrowse link
G Hsd11b2 hydroxysteroid 11-beta dehydrogenase 2 decreases activity ISO Maneb results in decreased activity of HSD11B2 protein CTD PMID:22796344 NCBI chr19:37,476,083...37,481,326
Ensembl chr19:37,476,095...37,481,307 		JBrowse link
G Hsf1 heat shock transcription factor 1 multiple interactions ISO [Maneb co-treated with Paraquat] results in decreased expression of HSF1 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of HSF1 mRNA]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of HSF1 mRNA] CTD PMID:23963992 NCBI chr 7:117,538,523...117,565,478
Ensembl chr 7:117,538,523...117,565,478 		JBrowse link
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 multiple interactions ISO [Maneb co-treated with Paraquat] results in decreased expression of HSP90AA1 mRNA; [Paraquat co-treated with Maneb] results in increased expression of HSP90AA1 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of HSP90AA1 mRNA] CTD PMID:18386188 PMID:23963992 NCBI chr 6:135,107,262...135,112,793
Ensembl chr 6:135,107,271...135,112,775 		JBrowse link
G Hspa1b heat shock protein family A (Hsp70) member 1B multiple interactions ISO [Maneb co-treated with Paraquat] results in decreased expression of HSPA1B mRNA; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of HSPA1B mRNA] CTD PMID:23963992 NCBI chr20:4,877,638...4,880,112
Ensembl chr20:2,699,712...2,701,815 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions ISO [Paraquat co-treated with Maneb] results in increased expression of HSPA5 mRNA CTD PMID:18386188 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762 		JBrowse link
G Hspa8 heat shock protein family A (Hsp70) member 8 multiple interactions ISO [Paraquat co-treated with Maneb] results in increased expression of HSPA8 mRNA CTD PMID:18386188 NCBI chr 8:44,989,401...44,993,261
Ensembl chr 8:44,990,014...44,993,179 		JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO [Paraquat co-treated with Maneb] results in increased expression of ICAM1 mRNA; Poloxamer inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of ICAM1 mRNA] CTD PMID:32169474 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059 		JBrowse link
G Icam2 intercellular adhesion molecule 2 multiple interactions ISO [Paraquat co-treated with Maneb] results in increased expression of ICAM2 mRNA; Poloxamer inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of ICAM2 mRNA] CTD PMID:32169474 NCBI chr10:94,569,889...94,581,218
Ensembl chr10:94,569,890...94,576,512 		JBrowse link
G Idh3a isocitrate dehydrogenase (NAD(+)) 3 catalytic subunit alpha multiple interactions ISO [Maneb co-treated with Paraquat] results in increased expression of IDH3A protein; Levodopa inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of IDH3A protein]; tetrakis(N-methyl-4-pyridiniumyl)porphine manganese(III) complex inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of IDH3A protein] CTD PMID:23562983 NCBI chr 8:59,164,601...59,183,899
Ensembl chr 8:59,164,572...59,183,908 		JBrowse link
G Ier5l immediate early response 5-like multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of IER5L mRNA CTD PMID:22563483 NCBI chr 3:9,036,351...9,037,942
Ensembl chr 3:9,036,373...9,037,942 		JBrowse link
G Ifng interferon gamma multiple interactions ISO [Maneb co-treated with Paraquat] results in increased expression of IFNG mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of IFNG mRNA]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of IFNG mRNA] CTD PMID:23963992 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419 		JBrowse link
G Igf1 insulin-like growth factor 1 multiple interactions ISO [Maneb co-treated with Paraquat] results in decreased expression of IGF1 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of IGF1 mRNA]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of IGF1 mRNA] CTD PMID:23963992 NCBI chr 7:28,412,123...28,491,815
Ensembl chr 7:28,412,198...28,486,609 		JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases expression		 EXP
ISO		 [Paraquat co-treated with Maneb] results in increased expression of IL1B mRNA; Acetylcysteine inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of IL1B mRNA]; Silymarin inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of IL1B mRNA]; Silymarin inhibits the reaction [Maneb results in increased expression of IL1B mRNA]
[Maneb co-treated with Paraquat] results in increased expression of IL1B mRNA; [Paraquat co-treated with Maneb] results in increased expression of IL1B mRNA; [Paraquat co-treated with Maneb] results in increased expression of IL1B protein; Glyburide inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of IL1B protein]; ITGAM protein affects the reaction [[Paraquat co-treated with Maneb] results in increased expression of IL1B mRNA]; ITGAM protein affects the reaction [[Paraquat co-treated with Maneb] results in increased expression of IL1B protein]; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of IL1B mRNA]; Poloxamer inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of IL1B mRNA]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of IL1B mRNA]; Taurine inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of IL1B mRNA]		 CTD PMID:23159886 PMID:23963992 PMID:29568078 PMID:32169474 PMID:32375810 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO [Paraquat co-treated with Maneb] results in increased expression of IL6 mRNA; Poloxamer inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of IL6 mRNA] CTD PMID:32169474 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807 		JBrowse link
G Inhba inhibin subunit beta A multiple interactions ISO [Maneb co-treated with Paraquat] results in decreased expression of INHBA mRNA; [Paraquat co-treated with Maneb] affects the expression of INHBA mRNA CTD PMID:22563483 PMID:23017109 NCBI chr17:51,894,869...51,919,998
Ensembl chr17:51,898,217...51,912,496 		JBrowse link
G Irs2 insulin receptor substrate 2 multiple interactions ISO [Maneb co-treated with Paraquat] results in decreased expression of IRS2 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of IRS2 mRNA] CTD PMID:23963992 NCBI chr16:83,824,515...83,848,569
Ensembl chr16:83,824,430...83,848,684 		JBrowse link
G Itgam integrin subunit alpha M multiple interactions ISO [Maneb co-treated with Paraquat] results in increased expression of ITGAM protein; [Paraquat co-treated with Maneb] results in increased expression of ITGAM mRNA; [Paraquat co-treated with Maneb] results in increased expression of ITGAM protein; acetovanillone inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of ITGAM protein]; acetovanillone inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of ITGAM protein]; ITGAM protein affects the reaction [[Paraquat co-treated with Maneb] results in increased cleavage of CASP1 protein]; ITGAM protein affects the reaction [[Paraquat co-treated with Maneb] results in increased expression of IL1B mRNA]; ITGAM protein affects the reaction [[Paraquat co-treated with Maneb] results in increased expression of IL1B protein]; ITGAM protein affects the reaction [[Paraquat co-treated with Maneb] results in increased expression of NLRP3 protein]; ITGAM protein affects the reaction [[Paraquat co-treated with Maneb] results in increased expression of TNF mRNA]; Poloxamer inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of ITGAM mRNA] CTD PMID:28202386 PMID:30797899 PMID:32169474 PMID:32375810 NCBI chr 1:199,495,312...199,545,738
Ensembl chr 1:199,495,298...199,623,960 		JBrowse link
G Itgb8 integrin subunit beta 8 multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of ITGB8 mRNA CTD PMID:22563483 NCBI chr 6:147,089,280...147,172,846
Ensembl chr 6:147,094,097...147,172,813 		JBrowse link
G Itpr1 inositol 1,4,5-trisphosphate receptor, type 1 multiple interactions ISO [Maneb co-treated with Paraquat] results in decreased expression of ITPR1 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of ITPR1 mRNA] CTD PMID:23963992 NCBI chr 4:140,247,297...140,580,749
Ensembl chr 4:140,247,313...140,580,748 		JBrowse link
G Jpt1 Jupiter microtubule associated homolog 1 multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of JPT1 mRNA CTD PMID:18386188 NCBI chr10:104,057,739...104,075,776
Ensembl chr10:104,057,697...104,075,777 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP [Paraquat co-treated with Maneb] results in decreased expression of JUN mRNA; [Paraquat co-treated with Maneb] results in decreased expression of JUN protein CTD PMID:27460631 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277 		JBrowse link
G Kcna2 potassium voltage-gated channel subfamily A member 2 multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of KCNA2 mRNA CTD PMID:22563483 NCBI chr 2:209,838,607...209,852,471
Ensembl chr 2:209,838,869...209,852,471 		JBrowse link
G Kcnma1 potassium calcium-activated channel subfamily M alpha 1 multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of KCNMA1 mRNA CTD PMID:22563483 NCBI chr15:344,204...1,048,849
Ensembl chr15:344,360...1,047,956 		JBrowse link
G Kif1b kinesin family member 1B multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of KIF1B mRNA CTD PMID:22563483 NCBI chr 5:165,994,803...166,133,497
Ensembl chr 5:165,938,576...166,133,491 		JBrowse link
G Kit KIT proto-oncogene receptor tyrosine kinase decreases expression EXP Maneb results in decreased expression of KIT CTD PMID:25803990 NCBI chr14:35,072,131...35,149,638
Ensembl chr14:35,072,108...35,149,610 		JBrowse link
G Klf2 Kruppel-like factor 2 multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of KLF2 mRNA CTD PMID:22563483 NCBI chr16:19,223,087...19,225,037
Ensembl chr16:19,223,087...19,225,037 		JBrowse link
G Klhl15 kelch-like family member 15 multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of KLHL15 mRNA CTD PMID:22563483 NCBI chr  X:63,342,277...63,390,915
Ensembl chr  X:63,343,546...63,389,989 		JBrowse link
G Lamc2 laminin subunit gamma 2 multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of LAMC2 mRNA CTD PMID:22563483 NCBI chr13:70,566,643...70,632,126
Ensembl chr13:70,566,643...70,626,252 		JBrowse link
G Lifr LIF receptor subunit alpha multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of LIFR mRNA CTD PMID:22563483 NCBI chr 2:56,424,910...56,489,346
Ensembl chr 2:56,426,367...56,489,415 		JBrowse link
G Limk2 LIM domain kinase 2 multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of LIMK2 mRNA CTD PMID:18386188 NCBI chr14:83,564,048...83,641,996
Ensembl chr14:83,573,928...83,641,892 		JBrowse link
G Loricrin loricrin cornified envelope precursor protein multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of LOR mRNA CTD PMID:22563483 NCBI chr 2:191,984,455...191,990,713
Ensembl chr 2:191,984,773...191,986,170 		JBrowse link
G Lrp4 LDL receptor related protein 4 multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of LRP4 mRNA CTD PMID:22563483 NCBI chr 3:80,362,643...80,416,684
Ensembl chr 3:80,362,858...80,416,679 		JBrowse link
G Lrrc17 leucine rich repeat containing 17 multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of LRRC17 mRNA CTD PMID:18386188 NCBI chr 4:10,108,184...10,138,652
Ensembl chr 4:10,108,192...10,138,652 		JBrowse link
G Lrrc41 leucine rich repeat containing 41 multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of LRRC41 mRNA CTD PMID:18386188 NCBI chr 5:134,927,609...134,948,530
Ensembl chr 5:134,927,609...134,948,529 		JBrowse link
G Lrrk2 leucine-rich repeat kinase 2 multiple interactions ISO [LRRK2 protein mutant form co-treated with Maneb co-treated with Paraquat] results in decreased expression of ACHE mRNA; [LRRK2 protein mutant form co-treated with Maneb co-treated with Paraquat] results in decreased expression of BMP4 mRNA; [LRRK2 protein mutant form co-treated with Maneb co-treated with Paraquat] results in decreased expression of CDK5R1 mRNA; [LRRK2 protein mutant form co-treated with Maneb co-treated with Paraquat] results in decreased expression of CDK5RAP1 mRNA; [LRRK2 protein mutant form co-treated with Maneb co-treated with Paraquat] results in decreased expression of CHRM2 mRNA; [LRRK2 protein mutant form co-treated with Maneb co-treated with Paraquat] results in decreased expression of EFNB1 mRNA; [LRRK2 protein mutant form co-treated with Maneb co-treated with Paraquat] results in decreased expression of FEZ1 mRNA; [LRRK2 protein mutant form co-treated with Maneb co-treated with Paraquat] results in decreased expression of HEY2 mRNA; [LRRK2 protein mutant form co-treated with Maneb co-treated with Paraquat] results in decreased expression of NDP mRNA; [LRRK2 protein mutant form co-treated with Maneb co-treated with Paraquat] results in decreased expression of NRG1 mRNA; [LRRK2 protein mutant form co-treated with Maneb co-treated with Paraquat] results in decreased expression of NTN1 mRNA; [LRRK2 protein mutant form co-treated with Maneb co-treated with Paraquat] results in decreased expression of PAX6 mRNA; [LRRK2 protein mutant form co-treated with Maneb co-treated with Paraquat] results in decreased expression of POU3F3 mRNA; [LRRK2 protein mutant form co-treated with Maneb co-treated with Paraquat] results in decreased expression of VEGFA mRNA; LRRK2 protein mutant form inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of CDK5RAP2 mRNA] CTD PMID:23017109 NCBI chr 7:132,857,311...133,018,549
Ensembl chr 7:132,857,628...133,018,584 		JBrowse link
G Lynx1 Ly6/neurotoxin 1 multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of LYNX1 mRNA CTD PMID:18386188 NCBI chr 7:115,982,877...115,988,121
Ensembl chr 7:115,982,876...115,988,090 		JBrowse link
G Macf1 microtubule-actin crosslinking factor 1 multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of MACF1 mRNA CTD PMID:18386188 NCBI chr 5:141,039,455...141,363,524
Ensembl chr 5:141,039,468...141,363,524 		JBrowse link
G Map2 microtubule-associated protein 2 multiple interactions ISO [Maneb co-treated with Paraquat] results in decreased expression of MAP2 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of MAP2 mRNA]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of MAP2 mRNA] CTD PMID:23963992 NCBI chr 9:73,204,753...73,462,965
Ensembl chr 9:73,319,710...73,462,972 		JBrowse link
G Map2k1 mitogen activated protein kinase kinase 1 multiple interactions ISO [Maneb co-treated with Paraquat] results in decreased expression of MAP2K1 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of MAP2K1 mRNA]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of MAP2K1 mRNA] CTD PMID:23963992 NCBI chr 8:69,134,218...69,722,573
Ensembl chr 8:69,134,223...69,164,758 		JBrowse link
G Map2k6 mitogen-activated protein kinase kinase 6 multiple interactions ISO [Maneb co-treated with Paraquat] results in increased expression of MAP2K6 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of MAP2K6 mRNA]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of MAP2K6 mRNA] CTD PMID:23963992 NCBI chr10:98,707,160...98,823,054
Ensembl chr10:98,706,960...98,823,287 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO [Paraquat co-treated with Maneb] results in increased phosphorylation of MAPK1 protein
[Paraquat co-treated with Maneb] results in increased phosphorylation of MAPK1 protein; acetovanillone inhibits the reaction [[Paraquat co-treated with Maneb] results in increased phosphorylation of MAPK1 protein]		 CTD PMID:15824117 PMID:30797899 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254 		JBrowse link
G Mapk15 mitogen-activated protein kinase 15 multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of MAPK15 mRNA CTD PMID:22563483 NCBI chr 7:117,041,287...117,061,799
Ensembl chr 7:117,055,395...117,061,047 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO [Paraquat co-treated with Maneb] results in increased phosphorylation of MAPK3 protein
[Paraquat co-treated with Maneb] results in increased phosphorylation of MAPK3 protein; acetovanillone inhibits the reaction [[Paraquat co-treated with Maneb] results in increased phosphorylation of MAPK3 protein]		 CTD PMID:15824117 PMID:30797899 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975 		JBrowse link
G Mapt microtubule-associated protein tau multiple interactions ISO [Maneb co-treated with Paraquat] results in decreased expression of MAPT mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of MAPT mRNA]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of MAPT mRNA] CTD PMID:23963992 NCBI chr10:92,289,002...92,386,517
Ensembl chr10:92,288,910...92,386,517 		JBrowse link
G Marchf9 membrane associated ring-CH-type finger 9 multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of MARCHF9 mRNA CTD PMID:22563483 NCBI chr 7:70,341,989...70,349,126 JBrowse link
G Mbd3 methyl-CpG binding domain protein 3 multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of MBD3 mRNA; [Paraquat co-treated with Maneb] results in increased expression of MBD3 mRNA CTD PMID:18386188 NCBI chr 7:12,179,046...12,186,251
Ensembl chr 7:12,179,203...12,186,656 		JBrowse link
G Mbnl1 muscleblind-like splicing regulator 1 multiple interactions ISO [Paraquat co-treated with Maneb] results in increased expression of MBNL1 mRNA CTD PMID:18386188 NCBI chr 2:150,698,248...150,867,791
Ensembl chr 2:150,756,185...150,869,690 		JBrowse link
G Mboat2 membrane bound O-acyltransferase domain containing 2 multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of MBOAT2 mRNA CTD PMID:22563483 NCBI chr 6:44,009,872...44,135,501
Ensembl chr 6:44,009,872...44,131,387 		JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member increases expression
multiple interactions		 ISO Maneb results in increased expression of MCL1 protein
[Paraquat co-treated with Maneb] results in increased expression of MCL1 protein		 CTD PMID:18266926 NCBI chr 2:197,786,212...197,788,992 JBrowse link
G Mdm4 MDM4 regulator of p53 multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of MDM4 mRNA CTD PMID:18386188 NCBI chr13:49,786,776...49,828,780
Ensembl chr13:49,792,794...49,828,720 		JBrowse link
G Mef2c myocyte enhancer factor 2C multiple interactions ISO [Maneb promotes the reaction [SNCA gene mutant form results in increased susceptibility to Paraquat]] which results in increased metabolism of MEF2C protein; [Paraquat promotes the reaction [SNCA gene mutant form results in increased susceptibility to Maneb]] which results in increased metabolism of MEF2C protein CTD PMID:24290359 NCBI chr 2:11,658,534...11,822,788
Ensembl chr 2:11,658,568...11,822,787 		JBrowse link
G Mfge8 milk fat globule EGF and factor V/VIII domain containing multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of MFGE8 mRNA CTD PMID:18386188 NCBI chr 1:140,845,478...140,860,882
Ensembl chr 1:140,845,465...140,860,894 		JBrowse link
G Mrc1 mannose receptor, C type 1 multiple interactions ISO [Paraquat co-treated with Maneb] results in increased expression of MRC1 mRNA CTD PMID:29568078 NCBI chr17:81,352,700...81,433,743
Ensembl chr17:81,352,700...81,433,743 		JBrowse link
G Mrpl15 mitochondrial ribosomal protein L15 multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of MRPL15 mRNA CTD PMID:18386188 NCBI chr 5:14,609,656...14,620,965
Ensembl chr 5:14,609,674...14,620,965 		JBrowse link
G Mrtfb myocardin related transcription factor B multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of MRTFB mRNA CTD PMID:22563483 NCBI chr10:1,151,163...1,273,269 JBrowse link
G Mt1 metallothionein 1 multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of MT1 mRNA CTD PMID:18386188 NCBI chr19:11,301,991...11,303,007
Ensembl chr17:78,793,336...78,793,724 		JBrowse link
G Mthfr methylenetetrahydrofolate reductase multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of MTHFR mRNA CTD PMID:18386188 NCBI chr 5:164,844,642...164,864,360
Ensembl chr 5:164,845,925...164,860,910 		JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions
increases expression		 ISO [Paraquat co-treated with Maneb] results in increased expression of MTOR protein; Maneb promotes the reaction [Paraquat results in increased expression of MTOR protein]; Paraquat promotes the reaction [Maneb results in increased expression of MTOR protein] CTD PMID:22292029 PMID:26884967 NCBI chr 5:165,263,813...165,373,967
Ensembl chr 5:165,263,800...165,373,967 		JBrowse link
G Muc6 mucin 6, oligomeric mucus/gel-forming multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of MUC6 mRNA CTD PMID:22563483 NCBI chr 1:214,608,453...214,630,524
Ensembl chr 1:214,608,704...214,629,938 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions ISO [alachlor co-treated with Captan co-treated with Diazinon co-treated with Endosulfan co-treated with mancozeb co-treated with Maneb] results in increased expression of MYC protein CTD PMID:19883720 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240 		JBrowse link
G Ncf1 neutrophil cytosolic factor 1 multiple interactions ISO [Maneb co-treated with Paraquat] affects the localization of NCF1 protein; [Paraquat co-treated with Maneb] results in increased expression of NCF1 protein; Glyburide inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of NCF1 protein]; Taurine inhibits the reaction [[Paraquat co-treated with Maneb] affects the localization of NCF1 protein]; Taurine inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of NCF1 protein] CTD PMID:28202386 PMID:29568078 PMID:32375810 NCBI chr12:25,497,104...25,506,300
Ensembl chr12:25,497,104...25,506,300 		JBrowse link
G Ndp norrin cystine knot growth factor NDP multiple interactions ISO [LRRK2 protein mutant form co-treated with Maneb co-treated with Paraquat] results in decreased expression of NDP mRNA CTD PMID:23017109 NCBI chr  X:6,791,090...6,815,586
Ensembl chr  X:6,791,136...6,815,583
Ensembl chr  X:6,791,136...6,815,583 		JBrowse link
G Neurod1 neuronal differentiation 1 multiple interactions ISO [Maneb co-treated with Paraquat] results in decreased expression of NEUROD1 mRNA CTD PMID:23017109 NCBI chr 3:66,414,314...66,417,617
Ensembl chr 3:66,414,308...66,417,741 		JBrowse link
G Nfat5 nuclear factor of activated T-cells 5 multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of NFAT5 mRNA CTD PMID:22563483 NCBI chr19:38,446,059...38,533,735
Ensembl chr19:38,446,059...38,533,735 		JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 increases expression
increases response to substance
multiple interactions		 ISO [Maneb results in increased expression of NFE2L2 protein] which results in increased expression of GCLC mRNA; [Maneb results in increased expression of NFE2L2 protein] which results in increased expression of NQO1 mRNA; [Maneb results in increased expression of NFE2L2 protein] which results in increased expression of PRDX1 mRNA; [Maneb results in increased expression of NFE2L2 protein] which results in increased expression of TXN1 mRNA; [Maneb results in increased expression of NFE2L2 protein] which results in increased expression of TXNRD1 mRNA; Maneb results in increased expression of NFE2L2 protein
NFE2L2 gene mutant form results in increased susceptibility to Maneb
[NFE2L2 gene mutant form results in increased susceptibility to Maneb] which results in decreased abundance of Glutathione; [NFE2L2 gene mutant form results in increased susceptibility to Maneb] which results in decreased expression of GSR protein; [NFE2L2 gene mutant form results in increased susceptibility to Maneb] which results in decreased expression of HMOX1 protein; [NFE2L2 gene mutant form results in increased susceptibility to Maneb] which results in increased abundance of Manganese; [NFE2L2 gene mutant form results in increased susceptibility to Maneb] which results in increased abundance of Thiobarbituric Acid Reactive Substances; NFE2L2 gene mutant form inhibits the reaction [Maneb results in increased expression of GPX4 mRNA]		 CTD PMID:21402726 PMID:23764462 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996 		JBrowse link
G Nfib nuclear factor I/B multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of NFIB mRNA CTD PMID:22563483 NCBI chr 5:100,436,343...100,647,962
Ensembl chr 5:100,439,082...100,647,727 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO [Maneb co-treated with Paraquat] results in increased expression of NFKB1 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of NFKB1 mRNA]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of NFKB1 mRNA] CTD PMID:23963992 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO [Maneb co-treated with Paraquat] results in increased phosphorylation of and results in decreased expression of NFKBIA protein; [Paraquat co-treated with Maneb] results in increased degradation of and results in increased phosphorylation of NFKBIA protein; acetovanillone inhibits the reaction [[Maneb co-treated with Paraquat] results in increased phosphorylation of and results in decreased expression of NFKBIA protein]; Taurine inhibits the reaction [[Paraquat co-treated with Maneb] results in increased degradation of and results in increased phosphorylation of NFKBIA protein] CTD PMID:28202386 PMID:29568078 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457 		JBrowse link
G Nipbl NIPBL, cohesin loading factor multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of NIPBL mRNA CTD PMID:22563483 NCBI chr 2:57,508,830...57,676,197
Ensembl chr 2:57,509,428...57,600,820 		JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions ISO [Paraquat co-treated with Maneb] results in increased expression of NLRP3 protein; Glyburide inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of NLRP3 protein]; ITGAM protein affects the reaction [[Paraquat co-treated with Maneb] results in increased expression of NLRP3 protein] CTD PMID:32375810 NCBI chr10:45,884,324...45,918,290
Ensembl chr10:45,893,018...45,918,254 		JBrowse link
G Nog noggin multiple interactions ISO [Maneb co-treated with Paraquat] results in decreased expression of NOG mRNA CTD PMID:23017109 NCBI chr10:76,811,759...76,813,386
Ensembl chr10:76,811,759...76,813,386 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
increases expression		 ISO
EXP		 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of NOS2 mRNA]; [Maneb co-treated with Paraquat] results in increased expression of NOS2 mRNA; [Paraquat co-treated with Maneb] results in increased expression of NOS2 mRNA; [Paraquat co-treated with Maneb] results in increased expression of NOS2 protein; acetovanillone inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of NOS2 mRNA]; acetovanillone inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of NOS2 mRNA]; Genistein inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of NOS2 mRNA]; Glyburide inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of NOS2 mRNA]; Glyburide inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of NOS2 protein]; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of NOS2 mRNA]; pimagedine inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of NOS2 mRNA]; prolinedithiocarbamate inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of NOS2 mRNA]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of NOS2 mRNA]; Taurine inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of NOS2 mRNA]
[Paraquat co-treated with Maneb] results in increased expression of NOS2 mRNA; Acetylcysteine inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of NOS2 mRNA]; Silymarin inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of NOS2 mRNA]; Silymarin inhibits the reaction [Maneb results in increased expression of NOS2 mRNA]		 CTD PMID:20455021 PMID:23159886 PMID:23963992 PMID:28202386 PMID:29568078 PMID:30797899 PMID:32375810 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190 		JBrowse link
G Nox1 NADPH oxidase 1 multiple interactions ISO [Paraquat co-treated with Maneb] results in increased expression of NOX1 mRNA; acetovanillone inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of NOX1 mRNA]; diphenyleneiodonium inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of NOX1 mRNA] CTD PMID:30797899 NCBI chr  X:104,909,328...104,932,508
Ensembl chr  X:104,909,326...104,932,508 		JBrowse link
G Nps neuropeptide S multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of NPS mRNA CTD PMID:22563483 NCBI chr 1:207,508,414...207,512,195
Ensembl chr 1:207,508,414...207,512,195 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression ISO [Maneb results in increased expression of NFE2L2 protein] which results in increased expression of NQO1 mRNA CTD PMID:21402726 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180 		JBrowse link
G Nr4a1 nuclear receptor subfamily 4, group A, member 1 multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of NR4A1 mRNA CTD PMID:22563483 NCBI chr 7:142,899,358...142,920,216
Ensembl chr 7:142,905,758...142,920,216 		JBrowse link
G Nr4a2 nuclear receptor subfamily 4, group A, member 2 multiple interactions EXP [Paraquat co-treated with Maneb] results in decreased expression of NR4A2 mRNA; [Paraquat co-treated with Maneb] results in decreased expression of NR4A2 protein CTD PMID:29152652 NCBI chr 3:43,111,258...43,128,391
Ensembl chr 3:43,111,240...43,119,159 		JBrowse link
G Nrg1 neuregulin 1 multiple interactions ISO [LRRK2 protein mutant form co-treated with Maneb co-treated with Paraquat] results in decreased expression of NRG1 mRNA CTD PMID:23017109 NCBI chr16:62,969,573...64,065,063
Ensembl chr16:63,837,216...64,057,434 		JBrowse link
G Nrtn neurturin multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of NRTN mRNA CTD PMID:22563483 NCBI chr 9:10,299,881...10,306,599
Ensembl chr 9:10,305,470...10,306,597 		JBrowse link
G Ntn1 netrin 1 multiple interactions ISO [LRRK2 protein mutant form co-treated with Maneb co-treated with Paraquat] results in decreased expression of NTN1 mRNA; [Maneb co-treated with Paraquat] results in decreased expression of NTN1 mRNA CTD PMID:23017109 NCBI chr10:54,761,925...54,982,072
Ensembl chr10:54,761,871...54,967,585 		JBrowse link
G Ntrk2 neurotrophic receptor tyrosine kinase 2 multiple interactions ISO [Maneb co-treated with Paraquat] results in decreased expression of NTRK2 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of NTRK2 mRNA]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of NTRK2 mRNA] CTD PMID:23963992 NCBI chr17:5,934,651...6,245,778
Ensembl chr17:5,933,729...6,244,676 		JBrowse link
G Oaz2 ornithine decarboxylase antizyme 2 multiple interactions ISO [Maneb co-treated with Paraquat] results in increased expression of OAZ2 mRNA; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of OAZ2 mRNA] CTD PMID:23963992 NCBI chr 8:71,216,011...71,229,788
Ensembl chr 8:71,216,178...71,228,713 		JBrowse link
G P2ry4 pyrimidinergic receptor P2Y4 multiple interactions ISO [Maneb co-treated with Paraquat] results in decreased expression of P2RY4 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of P2RY4 mRNA] CTD PMID:23963992 NCBI chr  X:70,421,599...70,447,109
Ensembl chr  X:70,426,951...70,428,364 		JBrowse link
G Pax5 paired box 5 multiple interactions ISO [SNCA protein co-treated with Maneb co-treated with Paraquat] results in decreased expression of PAX5 mRNA CTD PMID:23017109 NCBI chr 5:60,007,587...60,191,973
Ensembl chr 5:60,007,587...60,191,941 		JBrowse link
G Pax6 paired box 6 multiple interactions ISO [LRRK2 protein mutant form co-treated with Maneb co-treated with Paraquat] results in decreased expression of PAX6 mRNA CTD PMID:23017109 NCBI chr 3:95,700,241...95,728,682
Ensembl chr 3:95,707,386...95,728,624 		JBrowse link
G Pcdh7 protocadherin 7 multiple interactions ISO [Maneb co-treated with Paraquat] results in increased expression of PCDH7 mRNA; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of PCDH7 mRNA] CTD PMID:23963992 NCBI chr14:54,649,054...55,081,632
Ensembl chr14:55,072,200...55,081,551 		JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions ISO 3-bromo-7-nitroindazole inhibits the reaction [[Paraquat co-treated with Maneb] results in decreased expression of PCNA protein]; [Paraquat co-treated with Maneb] results in decreased expression of PCNA protein CTD PMID:23985028 NCBI chr 3:124,880,698...124,884,570
Ensembl chr 3:124,880,698...124,884,570 		JBrowse link
G Pcp2 Purkinje cell protein 2 multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of PCP2 mRNA CTD PMID:22563483 NCBI chr12:2,172,378...2,174,674
Ensembl chr12:2,172,378...2,174,131 		JBrowse link
G Pdcd10 programmed cell death 10 multiple interactions ISO [Paraquat co-treated with Maneb] results in increased expression of PDCD10 mRNA CTD PMID:18386188 NCBI chr 2:173,966,701...174,012,730
Ensembl chr 2:173,967,080...174,012,676 		JBrowse link
G Pde1b phosphodiesterase 1B multiple interactions ISO [Maneb co-treated with Paraquat] results in decreased expression of PDE1B mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of PDE1B mRNA] CTD PMID:23963992 NCBI chr 7:145,117,951...145,147,711
Ensembl chr 7:145,117,951...145,145,376 		JBrowse link
G Pdgfra platelet derived growth factor receptor alpha multiple interactions ISO [Maneb co-treated with Paraquat] results in increased expression of PDGFRA mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of PDGFRA mRNA] CTD PMID:23963992 NCBI chr14:35,527,926...35,581,130
Ensembl chr14:35,527,927...35,581,031 		JBrowse link
G Pdha1 pyruvate dehydrogenase E1 subunit alpha 1 multiple interactions ISO [Maneb co-treated with Paraquat] results in decreased expression of PDHA1 mRNA; [Maneb co-treated with Paraquat] results in increased expression of PDHA1 protein; Levodopa inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of PDHA1 protein]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of PDHA1 mRNA] CTD PMID:23562983 PMID:23963992 NCBI chr  X:37,329,779...37,343,410
Ensembl chr  X:37,329,779...37,343,410 		JBrowse link
G Pdyn prodynorphin multiple interactions EXP [Paraquat co-treated with Maneb] results in decreased expression of PDYN CTD PMID:24376148 NCBI chr 3:122,194,327...122,206,671
Ensembl chr 3:122,194,329...122,206,671 		JBrowse link
G Pebp1 phosphatidylethanolamine binding protein 1 multiple interactions ISO [Maneb co-treated with Paraquat] results in decreased expression of PEBP1 protein; Levodopa inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of PEBP1 protein] CTD PMID:23562983 NCBI chr12:45,026,948...45,031,148
Ensembl chr12:45,026,886...45,031,145 		JBrowse link
G Pgs1 phosphatidylglycerophosphate synthase 1 multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of PGS1 mRNA CTD PMID:18386188 NCBI chr10:106,994,595...107,030,208
Ensembl chr10:106,991,935...107,030,260 		JBrowse link
G Pigc phosphatidylinositol glycan anchor biosynthesis, class C multiple interactions ISO [Paraquat co-treated with Maneb] results in increased expression of PIGC mRNA CTD PMID:18386188 NCBI chr13:79,886,832...79,889,305
Ensembl chr13:79,886,832...79,889,304 		JBrowse link
G Plce1 phospholipase C, epsilon 1 multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of PLCE1 mRNA CTD PMID:22563483 NCBI chr 1:257,156,023...257,465,440
Ensembl chr 1:257,157,264...257,466,064 		JBrowse link
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 increases expression ISO Maneb results in increased expression of PMAIP1 mRNA; Maneb results in increased expression of PMAIP1 protein CTD PMID:18266926 NCBI chr18:62,159,128...62,179,635
Ensembl chr18:62,174,670...62,181,102 		JBrowse link
G Pnoc prepronociceptin multiple interactions EXP [Paraquat co-treated with Maneb] results in increased expression of PNOC CTD PMID:24376148 NCBI chr15:48,805,841...48,833,071
Ensembl chr15:48,805,228...48,833,285 		JBrowse link
G Polr1c RNA polymerase I and III subunit C multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of POLR1C mRNA CTD PMID:18386188 NCBI chr 9:17,120,759...17,124,871
Ensembl chr 9:17,120,759...17,124,871 		JBrowse link
G Polr2k RNA polymerase II, I and III subunit K multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of POLR2K mRNA CTD PMID:22563483 NCBI chr 7:74,939,010...74,992,594
Ensembl chr 7:74,989,223...74,992,582 		JBrowse link
G Pou3f3 POU class 3 homeobox 3 multiple interactions ISO [LRRK2 protein mutant form co-treated with Maneb co-treated with Paraquat] results in decreased expression of POU3F3 mRNA CTD PMID:23017109 NCBI chr 9:49,479,148...49,482,246
Ensembl chr 9:49,479,023...49,482,252 		JBrowse link
G Prdx1 peroxiredoxin 1 increases expression ISO [Maneb results in increased expression of NFE2L2 protein] which results in increased expression of PRDX1 mRNA CTD PMID:21402726 NCBI chr 5:135,536,413...135,551,986
Ensembl chr 5:135,536,413...135,551,990 		JBrowse link
G Prdx3 peroxiredoxin 3 multiple interactions ISO [Maneb co-treated with Paraquat] results in decreased expression of PRDX3 protein; Levodopa inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of PRDX3 protein]; Minocycline inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of PRDX3 protein]; tetrakis(N-methyl-4-pyridiniumyl)porphine manganese(III) complex inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of PRDX3 protein] CTD PMID:23562983 NCBI chr 1:282,238,774...282,251,193
Ensembl chr 1:282,238,773...282,251,257 		JBrowse link
G Prkaca protein kinase cAMP-activated catalytic subunit alpha multiple interactions EXP [Paraquat co-treated with Maneb] results in decreased expression of PRKACA mRNA; [Paraquat co-treated with Maneb] results in decreased expression of PRKACA protein CTD PMID:27460631 NCBI chr19:25,095,089...25,118,869
Ensembl chr19:25,095,089...25,118,860 		JBrowse link
G Prkcz protein kinase C, zeta multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of PRKCZ mRNA CTD PMID:18386188 NCBI chr 5:172,658,071...172,769,492
Ensembl chr 5:172,658,748...172,769,421 		JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase multiple interactions ISO 3-bromo-7-nitroindazole inhibits the reaction [[Paraquat co-treated with Maneb] results in increased nitrosation of PRKN protein]; [Paraquat co-treated with Maneb] results in increased expression of PRKN protein; [Paraquat co-treated with Maneb] results in increased nitrosation of PRKN protein CTD PMID:22563483 PMID:23985028 NCBI chr 1:48,880,015...50,069,998 JBrowse link
G Prl prolactin multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of PRL mRNA CTD PMID:22563483 NCBI chr17:39,814,236...39,824,299
Ensembl chr17:39,814,244...39,824,299 		JBrowse link
G Prr7 proline rich 7 (synaptic) multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of PRR7 mRNA CTD PMID:22563483 NCBI chr17:9,693,274...9,702,795
Ensembl chr17:9,694,168...9,695,292 		JBrowse link
G Psap prosaposin multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of PSAP mRNA CTD PMID:18386188 NCBI chr20:29,831,302...29,856,876
Ensembl chr20:29,831,314...29,856,875 		JBrowse link
G Psen1 presenilin 1 multiple interactions ISO [Maneb co-treated with Paraquat] results in increased expression of PSEN1 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of PSEN1 mRNA] CTD PMID:23963992 NCBI chr 6:107,169,514...107,221,000
Ensembl chr 6:107,169,528...107,216,798 		JBrowse link
G Psmb1 proteasome 20S subunit beta 1 multiple interactions ISO Maneb inhibits the reaction [Paraquat results in decreased expression of PSMB1 mRNA] CTD PMID:26498265 NCBI chr 1:57,470,878...57,491,359
Ensembl chr 1:57,470,632...57,489,727 		JBrowse link
G Psmc4 proteasome 26S subunit, ATPase 4 multiple interactions ISO [Maneb co-treated with Paraquat] results in decreased expression of PSMC4 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of PSMC4 mRNA]
[Paraquat co-treated with Maneb] results in decreased expression of PSMC4 mRNA		 CTD PMID:23963992 PMID:26498265 NCBI chr 1:84,978,220...84,986,536
Ensembl chr 1:84,978,206...84,986,581 		JBrowse link
G Ptk2b protein tyrosine kinase 2 beta multiple interactions ISO [alachlor co-treated with Captan co-treated with Diazinon co-treated with Endosulfan co-treated with mancozeb co-treated with Maneb] results in decreased expression of PTK2B protein modified form CTD PMID:19883720 NCBI chr15:42,827,306...42,947,796
Ensembl chr15:42,827,310...42,947,656 		JBrowse link
G Ptpn4 protein tyrosine phosphatase, non-receptor type 4 affects activity ISO Maneb affects the activity of PTPN4 protein CTD PMID:23611293 NCBI chr13:35,678,240...35,858,414
Ensembl chr13:35,678,240...35,858,390 		JBrowse link
G Ptpn9 protein tyrosine phosphatase, non-receptor type 9 affects activity ISO Maneb affects the activity of PTPN9 protein CTD PMID:23611293 NCBI chr 8:61,658,851...61,739,458
Ensembl chr 8:61,659,445...61,739,434 		JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase multiple interactions ISO [Maneb co-treated with Paraquat] results in decreased expression of RAF1 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of RAF1 mRNA]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of RAF1 mRNA] CTD PMID:23963992 NCBI chr 4:147,532,040...147,592,769
Ensembl chr 4:147,532,042...147,592,699 		JBrowse link
G Rb1 RB transcriptional corepressor 1 multiple interactions
increases expression		 EXP [Maneb co-treated with Paraquat] results in increased expression of RB1 mRNA; Acetylcysteine inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of RB1 mRNA]; Acetylcysteine inhibits the reaction [Maneb results in increased expression of RB1 mRNA] CTD PMID:29859004 NCBI chr15:55,081,582...55,209,060
Ensembl chr15:55,083,140...55,209,342 		JBrowse link
G Rbx1 ring-box 1 multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of RBX1 mRNA CTD PMID:18386188 NCBI chr 7:122,700,849...122,710,907
Ensembl chr 7:122,700,854...122,709,935 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO [Maneb co-treated with Paraquat] results in increased phosphorylation of RELA protein; [Paraquat co-treated with Maneb] results in increased phosphorylation of RELA protein; acetovanillone inhibits the reaction [[Maneb co-treated with Paraquat] results in increased phosphorylation of RELA protein]; Taurine inhibits the reaction [[Paraquat co-treated with Maneb] results in increased phosphorylation of RELA protein] CTD PMID:28202386 PMID:29568078 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249 		JBrowse link
G Ripk1 receptor interacting serine/threonine kinase 1 multiple interactions ISO [Maneb co-treated with Paraquat] results in increased expression of RIPK1 mRNA; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of RIPK1 mRNA] CTD PMID:23963992 NCBI chr17:31,537,580...31,569,904
Ensembl chr17:31,537,591...31,569,904 		JBrowse link
G Rock1 Rho-associated coiled-coil containing protein kinase 1 multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of ROCK1 mRNA CTD PMID:22563483 NCBI chr18:1,273,490...1,390,790
Ensembl chr18:1,273,453...1,390,190 		JBrowse link
G Rpl12 ribosomal protein L12 multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of RPL12 mRNA CTD PMID:18386188 NCBI chr 3:12,009,578...12,011,952
Ensembl chr 3:12,009,578...12,011,666 		JBrowse link
G Rpl19 ribosomal protein L19 multiple interactions ISO [Maneb co-treated with Paraquat] results in decreased expression of RPL19 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of RPL19 mRNA] CTD PMID:23963992 NCBI chr10:85,978,691...85,981,979
Ensembl chr10:85,978,691...85,981,979 		JBrowse link
G Rpl41 ribosomal protein L41 multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of RPL41 mRNA CTD PMID:18386188 NCBI chr 7:2,972,897...2,973,977
Ensembl chr 7:2,972,900...2,973,977 		JBrowse link
G Rpl8 ribosomal protein L8 multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of RPL8 mRNA CTD PMID:18386188 NCBI chr 7:117,967,608...117,969,886
Ensembl chr 7:118,507,224...118,509,256 		JBrowse link
G Rpl9 ribosomal protein L9 multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of RPL9 mRNA CTD PMID:18386188 NCBI chr14:44,524,419...44,527,613
Ensembl chr14:44,524,416...44,527,613 		JBrowse link
G Rps12 ribosomal protein S12 multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of RPS12 mRNA CTD PMID:18386188 NCBI chr 1:22,758,214...22,760,370
Ensembl chr 1:22,758,212...22,760,370 		JBrowse link
G Rps15 ribosomal protein S15 multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of RPS15 mRNA CTD PMID:18386188 NCBI chr 7:12,282,134...12,283,573
Ensembl chr 7:12,282,109...12,283,608 		JBrowse link
G Rps6ka2 ribosomal protein S6 kinase A2 multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of RPS6KA2 mRNA CTD PMID:18386188 NCBI chr 1:53,219,346...53,499,445
Ensembl chr 1:53,360,157...53,499,445 		JBrowse link
G Rtn4 reticulon 4 multiple interactions ISO [Maneb co-treated with Paraquat] results in increased expression of RTN4 mRNA CTD PMID:23017109 NCBI chr14:114,126,931...114,174,459
Ensembl chr14:114,126,943...114,174,458 		JBrowse link
G Rtn4rl2 reticulon 4 receptor-like 2 multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of RTN4RL2 mRNA CTD PMID:22563483 NCBI chr 3:72,272,814...72,289,310
Ensembl chr 3:72,273,424...72,289,310 		JBrowse link
G S100a8 S100 calcium binding protein A8 multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of S100A8 mRNA CTD PMID:22563483 NCBI chr 2:190,073,239...190,074,333
Ensembl chr 2:190,073,815...190,074,354 		JBrowse link
G S100a9 S100 calcium binding protein A9 multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of S100A9 mRNA CTD PMID:22563483 NCBI chr 2:190,097,436...190,100,209
Ensembl chr 2:190,097,554...190,100,276 		JBrowse link
G Scamp2 secretory carrier membrane protein 2 multiple interactions ISO [Maneb co-treated with Paraquat] results in decreased expression of SCAMP2 mRNA; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of SCAMP2 mRNA] CTD PMID:23963992 NCBI chr 8:62,341,584...62,368,215
Ensembl chr 8:62,341,613...62,368,214 		JBrowse link
G Scand1 SCAN domain-containing 1 multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of SCAND1 mRNA CTD PMID:22563483 NCBI chr 3:152,381,665...152,382,529
Ensembl chr 3:152,381,665...152,382,529 		JBrowse link
G Sdhb succinate dehydrogenase complex iron sulfur subunit B multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of SDHB mRNA CTD PMID:18386188 NCBI chr 5:159,484,378...159,505,063
Ensembl chr 5:159,484,370...159,505,064 		JBrowse link
G Sema4d semaphorin 4D multiple interactions ISO [SNCA protein co-treated with Maneb co-treated with Paraquat] results in decreased expression of SEMA4D mRNA CTD PMID:23017109 NCBI chr17:13,516,276...13,538,513
Ensembl chr17:13,488,376...13,553,974 		JBrowse link
G Sirt1 sirtuin 1 decreases activity ISO Maneb results in decreased activity of SIRT1 protein CTD PMID:21251949 NCBI chr20:26,831,971...26,851,587
Ensembl chr20:26,833,357...26,852,199 		JBrowse link
G Sirt2 sirtuin 2 decreases activity ISO Maneb results in decreased activity of SIRT2 protein CTD PMID:21251949 NCBI chr 1:86,948,866...86,971,954
Ensembl chr 1:86,948,918...86,971,952 		JBrowse link
G Sirt3 sirtuin 3 decreases activity ISO Maneb results in decreased activity of SIRT3 protein CTD PMID:21251949 NCBI chr 1:213,613,502...213,636,061
Ensembl chr 1:213,613,513...213,635,546 		JBrowse link
G Slc17a8 solute carrier family 17 member 8 multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of SLC17A8 mRNA CTD PMID:22563483 NCBI chr 7:30,215,231...30,274,993
Ensembl chr 7:30,216,104...30,274,984 		JBrowse link
G Slc18a2 solute carrier family 18 member A2 multiple interactions
decreases expression		 ISO [Paraquat co-treated with Maneb] results in decreased expression of SLC18A2 mRNA; Ketoconazole inhibits the reaction [Maneb results in decreased expression of SLC18A2 protein]; Melatonin inhibits the reaction [[Paraquat co-treated with Maneb] results in decreased expression of SLC18A2 mRNA]; Silymarin inhibits the reaction [[Paraquat co-treated with Maneb] results in decreased expression of SLC18A2 mRNA] CTD PMID:18386188 PMID:20964710 PMID:22334051 NCBI chr 1:280,397,831...280,457,968
Ensembl chr 1:280,423,079...280,457,148 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO [Maneb co-treated with Paraquat] results in decreased expression of SLC22A2 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of SLC22A2 mRNA] CTD PMID:23963992 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261 		JBrowse link
G Slc40a1 solute carrier family 40 member 1 multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of SLC40A1 protein; acetovanillone inhibits the reaction [[Paraquat co-treated with Maneb] results in decreased expression of SLC40A1 protein] CTD PMID:30797899 NCBI chr 9:52,819,451...52,830,461
Ensembl chr 9:52,894,365...52,912,293 		JBrowse link
G Slc5a7 solute carrier family 5 member 7 multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of SLC5A7 mRNA CTD PMID:22563483 NCBI chr 9:5,294,377...5,330,822
Ensembl chr 9:5,294,381...5,330,815 		JBrowse link
G Slc6a2 solute carrier family 6 member 2 multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of SLC6A2 mRNA CTD PMID:22563483 NCBI chr19:15,391,682...15,431,274
Ensembl chr19:15,391,581...15,431,274 		JBrowse link
G Slc6a3 solute carrier family 6 member 3 multiple interactions
affects response to substance		 ISO [Paraquat co-treated with Maneb] results in decreased expression of SLC6A3 mRNA; [Paraquat co-treated with Maneb] results in decreased expression of SLC6A3 protein
SLC6A3 gene polymorphism affects the susceptibility to Maneb		 CTD PMID:11124998 PMID:18386188 PMID:19590691 NCBI chr 1:32,323,011...32,363,983
Ensembl chr 1:32,321,580...32,363,983 		JBrowse link
G Slc8a1 solute carrier family 8 member A1 multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of SLC8A1 mRNA CTD PMID:22563483 NCBI chr 6:4,244,076...4,564,262
Ensembl chr 6:4,258,991...4,520,604 		JBrowse link
G Snca synuclein alpha multiple interactions
increases response to substance		 ISO [Paraquat co-treated with Maneb] promotes the reaction [SNCA protein binds to SNCA protein]; [Paraquat co-treated with Maneb] results in increased expression of SNCA protein; [SNCA protein co-treated with Maneb co-treated with Paraquat] results in decreased expression of ADORA1 mRNA; [SNCA protein co-treated with Maneb co-treated with Paraquat] results in decreased expression of APBB1 mRNA; [SNCA protein co-treated with Maneb co-treated with Paraquat] results in decreased expression of ASCL1 mRNA; [SNCA protein co-treated with Maneb co-treated with Paraquat] results in decreased expression of BMP2 mRNA; [SNCA protein co-treated with Maneb co-treated with Paraquat] results in decreased expression of BMP4 mRNA; [SNCA protein co-treated with Maneb co-treated with Paraquat] results in decreased expression of DLL1 mRNA; [SNCA protein co-treated with Maneb co-treated with Paraquat] results in decreased expression of DRD2 mRNA; [SNCA protein co-treated with Maneb co-treated with Paraquat] results in decreased expression of DRD5 mRNA; [SNCA protein co-treated with Maneb co-treated with Paraquat] results in decreased expression of HEYL mRNA; [SNCA protein co-treated with Maneb co-treated with Paraquat] results in decreased expression of PAX5 mRNA; [SNCA protein co-treated with Maneb co-treated with Paraquat] results in decreased expression of SEMA4D mRNA; [SNCA protein co-treated with Maneb co-treated with Paraquat] results in decreased expression of VEGFA mRNA; Glyburide inhibits the reaction [[Paraquat co-treated with Maneb] promotes the reaction [SNCA protein binds to SNCA protein]]; Glyburide inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of SNCA protein]; SNCA protein inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of CDK5RAP2 mRNA]; Taurine inhibits the reaction [[Paraquat co-treated with Maneb] promotes the reaction [SNCA protein binds to SNCA protein]]
SNCA gene mutant form results in increased susceptibility to Maneb
[Maneb promotes the reaction [SNCA gene mutant form results in increased susceptibility to Paraquat]] which results in increased abundance of Nitric Oxide; [Maneb promotes the reaction [SNCA gene mutant form results in increased susceptibility to Paraquat]] which results in increased metabolism of MEF2C protein; [Paraquat promotes the reaction [SNCA gene mutant form results in increased susceptibility to Maneb]] which results in increased abundance of Nitric Oxide; [Paraquat promotes the reaction [SNCA gene mutant form results in increased susceptibility to Maneb]] which results in increased metabolism of MEF2C protein; Maneb promotes the reaction [Paraquat results in increased expression of SNCA protein]; Maneb promotes the reaction [SNCA gene mutant form results in increased susceptibility to Paraquat]; Paraquat promotes the reaction [SNCA gene mutant form results in increased susceptibility to Maneb]; SNCA protein mutant form results in increased susceptibility to [Paraquat co-treated with Maneb]; SNCA protein results in increased susceptibility to [Maneb co-treated with Paraquat]		 CTD PMID:23017109 PMID:24290359 PMID:26498265 PMID:27324791 PMID:29568078 PMID:32375810 NCBI chr 4:90,782,412...90,883,236
Ensembl chr 4:90,782,374...90,882,285 		JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions ISO
EXP		 SOD1 protein results in decreased susceptibility to [Paraquat co-treated with Maneb]
[Maneb co-treated with Paraquat] results in increased expression of SOD1 mRNA
[Paraquat co-treated with Maneb] results in decreased expression of SOD1 mRNA		 CTD PMID:15824117 PMID:18386188 PMID:29859004 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862 		JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions
decreases expression		 ISO [Maneb co-treated with Paraquat] results in decreased expression of SOD2 protein; Levodopa inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of SOD2 protein]; Minocycline inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of SOD2 protein]; tetrakis(N-methyl-4-pyridiniumyl)porphine manganese(III) complex inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of SOD2 protein]
Maneb results in decreased expression of SOD2 mRNA		 CTD PMID:23562983 PMID:26210702 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO [Maneb co-treated with Paraquat] results in decreased expression of STAT3 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of STAT3 mRNA]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of STAT3 mRNA] CTD PMID:23963992 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233 		JBrowse link
G Stat4 signal transducer and activator of transcription 4 multiple interactions ISO [Maneb co-treated with Paraquat] results in decreased expression of STAT4 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of STAT4 mRNA]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of STAT4 mRNA] CTD PMID:23963992 NCBI chr 9:54,340,649...54,457,753
Ensembl chr 9:54,287,541...54,484,533 		JBrowse link
G Stmn1 stathmin 1 multiple interactions ISO [Maneb co-treated with Paraquat] results in decreased expression of STMN1 protein; Levodopa inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of STMN1 protein]; Minocycline inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of STMN1 protein]; tetrakis(N-methyl-4-pyridiniumyl)porphine manganese(III) complex inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of STMN1 protein] CTD PMID:23562983 NCBI chr 5:152,680,412...152,686,807
Ensembl chr 5:152,680,407...152,686,806 		JBrowse link
G Ston2 stonin 2 multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of STON2 mRNA CTD PMID:22563483 NCBI chr 6:115,398,586...115,547,552
Ensembl chr 6:115,399,326...115,513,354 		JBrowse link
G Strbp spermatid perinuclear RNA binding protein multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of STRBP mRNA CTD PMID:22563483 NCBI chr 3:21,817,680...21,956,988
Ensembl chr 3:21,828,298...21,904,270 		JBrowse link
G Sumo1 small ubiquitin-like modifier 1 multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of SUMO1 mRNA CTD PMID:18386188 NCBI chr 9:66,453,428...66,483,614
Ensembl chr 9:66,453,438...66,483,614 		JBrowse link
G Syt5 synaptotagmin 5 multiple interactions ISO [Maneb co-treated with Paraquat] results in decreased expression of SYT5 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of SYT5 mRNA]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of SYT5 mRNA] CTD PMID:23963992 NCBI chr 1:72,859,806...72,867,934
Ensembl chr 1:72,860,218...72,867,930 		JBrowse link
G Tbck TBC1 domain containing kinase multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of TBCK mRNA CTD PMID:22563483 NCBI chr 2:237,751,646...237,958,497
Ensembl chr 2:237,751,654...237,958,497 		JBrowse link
G Tecr trans-2,3-enoyl-CoA reductase multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of TECR mRNA CTD PMID:18386188 NCBI chr19:24,705,478...24,732,024
Ensembl chr19:24,705,481...24,732,024 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO [Maneb co-treated with Paraquat] results in increased expression of TGFB1 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of TGFB1 mRNA]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of TGFB1 mRNA] CTD PMID:23963992 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199 		JBrowse link
G Th tyrosine hydroxylase multiple interactions
decreases expression		 ISO
EXP		 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of TH protein]; [Paraquat co-treated with Maneb] results in decreased expression of TH protein; [Paraquat co-treated with Maneb] results in increased expression of TH protein; Genistein inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of TH protein]; Ketoconazole inhibits the reaction [Maneb results in decreased expression of TH protein]; Melatonin inhibits the reaction [[Paraquat co-treated with Maneb] results in decreased expression of TH protein]; pimagedine inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of TH protein]; prolinedithiocarbamate inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of TH protein]; Silymarin inhibits the reaction [[Paraquat co-treated with Maneb] results in decreased expression of TH protein]
[Paraquat co-treated with Maneb] results in decreased expression of TH; [Paraquat co-treated with Maneb] results in decreased expression of TH mRNA; [Paraquat co-treated with Maneb] results in decreased expression of TH protein		 CTD PMID:11124998 PMID:18386188 PMID:20455021 PMID:20964710 PMID:22334051 PMID:24376148 PMID:24486957 PMID:29152652 NCBI chr 1:216,073,034...216,080,287
Ensembl chr 1:216,073,031...216,080,287 		JBrowse link
G Timm13 translocase of inner mitochondrial membrane 13 multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of TIMM13 mRNA CTD PMID:18386188 NCBI chr 7:11,677,340...11,678,443
Ensembl chr 7:11,677,340...11,678,442 		JBrowse link
G Tmem42 transmembrane protein 42 multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of TMEM42 mRNA CTD PMID:22563483 NCBI chr 8:132,105,965...132,108,462
Ensembl chr 8:132,105,443...132,108,462 		JBrowse link
G Tnf tumor necrosis factor increases expression
multiple interactions		 EXP
ISO		 Maneb results in increased expression of TNF mRNA
[Maneb co-treated with Paraquat] results in increased expression of TNF mRNA; [Paraquat co-treated with Maneb] results in increased expression of TNF mRNA; acetovanillone inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of TNF mRNA]; acetovanillone inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of TNF mRNA]; Glyburide inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of TNF mRNA]; ITGAM protein affects the reaction [[Paraquat co-treated with Maneb] results in increased expression of TNF mRNA]; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of TNF mRNA]; Poloxamer inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of TNF mRNA]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of TNF mRNA]; Taurine inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of TNF mRNA]
[Paraquat co-treated with Maneb] results in increased expression of TNF mRNA; Acetylcysteine inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of TNF mRNA]; Silymarin inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of TNF mRNA]; Silymarin inhibits the reaction [Maneb results in increased expression of TNF mRNA]		 CTD PMID:23159886 PMID:23963992 PMID:28202386 PMID:29568078 PMID:30797899 PMID:32169474 PMID:32375810 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000 		JBrowse link
G Tnfaip3 TNF alpha induced protein 3 multiple interactions ISO [Maneb co-treated with Paraquat] results in increased expression of TNFAIP3 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of TNFAIP3 mRNA] CTD PMID:23963992 NCBI chr 1:14,401,103...14,416,369
Ensembl chr 1:14,402,913...14,412,807 		JBrowse link
G Tnr tenascin R multiple interactions ISO [Maneb co-treated with Paraquat] results in decreased expression of TNR mRNA CTD PMID:23017109 NCBI chr13:77,602,249...77,678,385
Ensembl chr13:77,485,113...77,678,437 		JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO 3-bromo-7-nitroindazole inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of TRP53 protein]; [Maneb co-treated with Paraquat] results in increased expression of TRP53 mRNA; [Paraquat co-treated with Maneb] results in decreased expression of TRP53 protein; [Paraquat co-treated with Maneb] results in increased activity of TRP53 protein modified form; [Paraquat co-treated with Maneb] results in increased expression of TRP53 protein; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of TRP53 mRNA]; Melatonin inhibits the reaction [[Paraquat co-treated with Maneb] results in decreased expression of TRP53 protein]; Melatonin inhibits the reaction [[Paraquat co-treated with Maneb] results in increased activity of TRP53 protein modified form]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of TRP53 mRNA]; Silymarin inhibits the reaction [[Paraquat co-treated with Maneb] results in decreased expression of TRP53 protein]; Silymarin inhibits the reaction [[Paraquat co-treated with Maneb] results in increased activity of TRP53 protein modified form] CTD PMID:20964710 PMID:23963992 PMID:23985028 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449 		JBrowse link
G Traf3ip2 Traf3 interacting protein 2 multiple interactions ISO [Maneb co-treated with Paraquat] results in increased expression of ACT1 protein CTD PMID:23562983 NCBI chr20:44,679,861...44,722,874
Ensembl chr20:44,680,449...44,722,872 		JBrowse link
G Traf6 TNF receptor associated factor 6 multiple interactions ISO [Maneb co-treated with Paraquat] results in increased expression of TRAF6 mRNA; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of TRAF6 mRNA] CTD PMID:23963992 NCBI chr 3:91,252,829...91,271,607
Ensembl chr 3:91,252,829...91,271,607 		JBrowse link
G Trpm3 transient receptor potential cation channel, subfamily M, member 3 multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of TRPM3 mRNA CTD PMID:22563483 NCBI chr 1:239,741,572...240,757,583
Ensembl chr 1:240,355,149...240,757,583 		JBrowse link
G Tuba1a tubulin, alpha 1A multiple interactions ISO [Maneb co-treated with Paraquat] results in increased expression of TUBA1A protein; Levodopa inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of TUBA1A protein]; Minocycline inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of TUBA1A protein]; tetrakis(N-methyl-4-pyridiniumyl)porphine manganese(III) complex inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of TUBA1A protein] CTD PMID:23562983 NCBI chr 7:140,637,287...140,640,953
Ensembl chr 7:140,637,287...140,640,953 		JBrowse link
G Tuba1b tubulin, alpha 1B multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of TUBA1B mRNA CTD PMID:18386188 NCBI chr 7:140,614,746...140,617,721
Ensembl chr 7:140,614,752...140,617,721 		JBrowse link
G Tubb5 tubulin, beta 5 class I multiple interactions ISO [Maneb co-treated with Paraquat] results in decreased expression of TUBB5 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of TUBB5 mRNA] CTD PMID:23963992 NCBI chr20:3,422,448...3,426,420
Ensembl chr20:3,422,461...3,426,371 		JBrowse link
G Txn1 thioredoxin 1 increases expression ISO [Maneb results in increased expression of NFE2L2 protein] which results in increased expression of TXN1 mRNA CTD PMID:21402726 NCBI chr 5:75,049,735...75,057,731
Ensembl chr 5:75,049,747...75,057,752 		JBrowse link
G Txnrd1 thioredoxin reductase 1 increases expression ISO [Maneb results in increased expression of NFE2L2 protein] which results in increased expression of TXNRD1 mRNA CTD PMID:21402726 NCBI chr 7:26,946,124...26,984,400
Ensembl chr 7:26,946,125...26,984,400 		JBrowse link
G Uba1 ubiquitin-like modifier activating enzyme 1 multiple interactions ISO Maneb results in decreased activity of and results in decreased ubiquitination of UBA1 protein CTD PMID:25714994 NCBI chr  X:1,723,135...1,745,147
Ensembl chr  X:1,723,174...1,741,701 		JBrowse link
G Ubb ubiquitin B multiple interactions ISO [Maneb co-treated with Paraquat] results in decreased expression of UBB mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of UBB mRNA]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of UBB mRNA] CTD PMID:23963992 NCBI chr10:48,880,231...48,881,896
Ensembl chr10:48,881,049...48,881,881 		JBrowse link
G Ubc ubiquitin C multiple interactions ISO [Paraquat co-treated with Maneb] results in increased expression of UBC mRNA CTD PMID:18386188 NCBI chr12:36,638,457...36,642,734
Ensembl chr12:36,638,457...36,642,734 		JBrowse link
G Ubxn7 UBX domain protein 7 multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of UBXN7 mRNA CTD PMID:22563483 NCBI chr11:71,662,786...71,695,031 JBrowse link
G Uchl1 ubiquitin C-terminal hydrolase L1 multiple interactions ISO [Maneb co-treated with Paraquat] results in decreased expression of UCHL1 protein; [Paraquat co-treated with Maneb] results in decreased expression of UCHL1 mRNA CTD PMID:18386188 PMID:23562983 NCBI chr14:43,133,224...43,143,942
Ensembl chr14:43,133,218...43,143,973 		JBrowse link
G Uchl5 ubiquitin C-terminal hydrolase L5 multiple interactions ISO [Paraquat co-treated with Maneb] results in increased expression of UCHL5 mRNA CTD PMID:18386188 NCBI chr13:60,568,102...60,603,812
Ensembl chr13:60,545,635...60,603,811 		JBrowse link
G Unc13c unc-13 homolog C multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of UNC13C mRNA CTD PMID:22563483 NCBI chr 8:80,202,736...80,656,363
Ensembl chr 8:80,203,609...80,631,926 		JBrowse link
G Upf3b UPF3B, regulator of nonsense mediated mRNA decay multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of UPF3B mRNA CTD PMID:18386188 NCBI chr  X:123,713,327...123,731,431
Ensembl chr  X:123,713,339...123,731,385 		JBrowse link
G Uqcrc1 ubiquinol-cytochrome c reductase core protein 1 multiple interactions ISO [Maneb co-treated with Paraquat] results in increased expression of UQCRC1 protein; Levodopa inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of UQCRC1 protein]; tetrakis(N-methyl-4-pyridiniumyl)porphine manganese(III) complex inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of UQCRC1 protein] CTD PMID:23562983 NCBI chr 8:117,679,328...117,691,073
Ensembl chr 8:117,679,278...117,691,071 		JBrowse link
G Vamp5 vesicle-associated membrane protein 5 multiple interactions ISO [Maneb co-treated with Paraquat] results in decreased expression of VAMP5 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of VAMP5 mRNA]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of VAMP5 mRNA] CTD PMID:23963992 NCBI chr 4:100,231,561...100,232,560
Ensembl chr 4:100,231,561...100,232,559 		JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO [LRRK2 protein mutant form co-treated with Maneb co-treated with Paraquat] results in decreased expression of VEGFA mRNA; [SNCA protein co-treated with Maneb co-treated with Paraquat] results in decreased expression of VEGFA mRNA CTD PMID:23017109 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681 		JBrowse link
G Vps45 vacuolar protein sorting 45 homolog multiple interactions ISO [Maneb co-treated with Paraquat] results in decreased expression of VPS45 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of VPS45 mRNA] CTD PMID:23963992 NCBI chr 2:198,123,747...198,184,739
Ensembl chr 2:198,123,748...198,184,739 		JBrowse link
G Wnt1 Wnt family member 1 multiple interactions EXP [Paraquat co-treated with Maneb] results in decreased expression of WNT1 mRNA; [Paraquat co-treated with Maneb] results in decreased expression of WNT1 protein CTD PMID:29152652 NCBI chr 7:140,464,999...140,469,046
Ensembl chr 7:140,464,999...140,469,046 		JBrowse link
G Wnt5a Wnt family member 5A multiple interactions EXP [Paraquat co-treated with Maneb] results in increased expression of WNT5A mRNA; [Paraquat co-treated with Maneb] results in increased expression of WNT5A protein CTD PMID:29152652 NCBI chr16:4,469,451...4,490,271
Ensembl chr16:4,469,468...4,489,860 		JBrowse link
G Zbtb44 zinc finger and BTB domain containing 44 multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of ZBTB44 mRNA CTD PMID:22563483 NCBI chr 8:32,165,388...32,223,341
Ensembl chr 8:32,165,810...32,217,476 		JBrowse link
G Zfp580 zinc finger protein 580 multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of ZFP580 mRNA CTD PMID:22563483 NCBI chr 1:72,338,468...72,340,636
Ensembl chr 1:72,338,877...72,339,395 		JBrowse link
G Zhx3 zinc fingers and homeoboxes 3 multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of ZHX3 mRNA CTD PMID:22563483 NCBI chr 3:156,759,820...156,868,173
Ensembl chr 3:156,764,751...156,777,999 		JBrowse link
manganese dioxide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase decreases expression EXP manganese dioxide results in decreased expression of ACHE protein CTD PMID:23702825 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753 		JBrowse link
G Gpt glutamic--pyruvic transaminase increases activity EXP manganese dioxide results in increased activity of GPT protein CTD PMID:23702825 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931 		JBrowse link
manganese(0) term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca5 ATP binding cassette subfamily A member 5 decreases expression ISO Manganese results in decreased expression of ABCA5 mRNA CTD PMID:17175027 NCBI chr10:98,573,226...98,645,028
Ensembl chr10:98,576,039...98,644,938 		JBrowse link
G Abca9 ATP binding cassette subfamily A member 9 increases expression ISO Manganese results in increased expression of ABCA9 mRNA CTD PMID:17175027 NCBI chr10:98,412,263...98,472,258
Ensembl chr10:98,412,263...98,469,799 		JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A increases activity
increases expression
multiple interactions		 ISO
EXP		 Manganese results in increased activity of ABCB1 protein
Manganese results in increased expression of ABCB1A mRNA
[Manganese results in increased activity of ABCB1 protein] which results in increased hydrolysis of Adenosine Triphosphate		 CTD PMID:2900677 PMID:26745496 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515 		JBrowse link
G Abcc6 ATP binding cassette subfamily C member 6 multiple interactions EXP Manganese promotes the reaction [8-azidoadenosine 5'-triphosphate binds to ABCC6 protein]; Manganese promotes the reaction [beryllium fluoride promotes the reaction [8-azidoadenosine 5'-triphosphate binds to ABCC6 protein]] CTD PMID:12069597 NCBI chr 1:101,954,786...102,013,252
Ensembl chr 1:101,959,540...102,013,243 		JBrowse link
G Abcc8 ATP binding cassette subfamily C member 8 multiple interactions ISO [manganese chloride results in increased abundance of Manganese] which results in increased expression of ABCC8 protein CTD PMID:32659473 NCBI chr 1:102,110,708...102,191,287
Ensembl chr 1:102,110,708...102,191,287 		JBrowse link
G Abi2 abl-interactor 2 increases expression ISO Manganese results in increased expression of ABI2 mRNA CTD PMID:17175027 NCBI chr 9:67,234,612...67,284,504
Ensembl chr 9:67,234,303...67,282,600 		JBrowse link
G Acat2 acetyl-CoA acetyltransferase 2 decreases expression ISO Manganese results in decreased expression of ACAT2 mRNA CTD PMID:23499988 NCBI chr 1:47,972,399...47,992,654
Ensembl chr 1:47,972,399...47,992,653 		JBrowse link
G Ache acetylcholinesterase multiple interactions
increases activity		 EXP
ISO		 [manganese chloride results in increased abundance of Manganese] promotes the reaction [Ethanol results in increased activity of ACHE protein]; [manganese chloride results in increased abundance of Manganese] which results in increased activity of ACHE protein; Ethanol promotes the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased activity of ACHE protein]; Taurine inhibits the reaction [Manganese results in increased activity of ACHE protein]
[manganese chloride results in increased abundance of Manganese] which results in decreased activity of ACHE protein; [manganese chloride results in increased abundance of Manganese] which results in increased activity of ACHE protein; [manganese chloride results in increased abundance of Manganese] which results in increased expression of ACHE mRNA alternative form		 CTD PMID:24885898 PMID:30738988 PMID:30844427 PMID:32445656 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753 		JBrowse link
G Aco1 aconitase 1 decreases activity
increases activity
multiple interactions		 EXP
ISO		 Manganese results in decreased activity of ACO1 protein
Manganese results in increased activity of ACO1 protein
Manganese results in increased stability of [ACO1 protein binds to SLC11A2 mRNA]		 CTD PMID:16386771 PMID:16545456 PMID:16568477 PMID:16729984 PMID:17469137 NCBI chr 5:56,425,076...56,481,218
Ensembl chr 5:56,425,024...56,481,218 		JBrowse link
G Aco2 aconitase 2 multiple interactions
decreases activity
decreases expression		 ISO
EXP		 ferric ammonium citrate inhibits the reaction [Manganese results in decreased activity of ACO2 protein]
Iron inhibits the reaction [Manganese results in decreased activity of ACO2 protein]
Manganese results in decreased expression of ACO2 mRNA; Manganese results in decreased expression of ACO2 protein		 CTD PMID:9675333 PMID:16625280 PMID:17469137 NCBI chr 7:123,102,493...123,145,608
Ensembl chr 7:123,102,468...123,145,635 		JBrowse link
G Acta1 actin, alpha 1, skeletal muscle decreases expression EXP Manganese results in decreased expression of ACTA1 mRNA CTD PMID:26745496 NCBI chr19:56,674,072...56,677,084
Ensembl chr19:56,674,074...56,677,084 		JBrowse link
G Actr3 actin related protein 3 affects expression EXP Manganese affects the expression of ACTR3 protein CTD PMID:24885898 NCBI chr13:41,695,520...41,738,622
Ensembl chr13:41,695,183...41,738,658 		JBrowse link
G Adgre1 adhesion G protein-coupled receptor E1 increases expression EXP Manganese results in increased expression of ADGRE1 mRNA CTD PMID:20224926 NCBI chr 9:9,431,888...9,585,883
Ensembl chr 9:9,431,860...9,585,865 		JBrowse link
G Adm adrenomedullin increases expression ISO Manganese results in increased expression of ADM mRNA CTD PMID:17175027 NCBI chr 1:175,443,189...175,447,260
Ensembl chr 1:175,445,088...175,447,259 		JBrowse link
G Afp alpha-fetoprotein decreases expression EXP Manganese results in decreased expression of AFP mRNA CTD PMID:26745496 NCBI chr14:19,141,755...19,159,919
Ensembl chr14:19,141,755...19,159,923 		JBrowse link
G Akap7 A-kinase anchoring protein 7 decreases expression ISO Manganese results in decreased expression of AKAP7 mRNA CTD PMID:17175027 NCBI chr 1:21,129,213...21,263,850
Ensembl chr 1:21,141,970...21,263,850 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 decreases expression
multiple interactions
increases phosphorylation		 ISO
EXP		 Manganese results in decreased expression of AKT1 protein
[manganese chloride results in increased abundance of Manganese] which results in decreased phosphorylation of AKT1 protein; benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in decreased phosphorylation of AKT1 protein]
NTF3 protein inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in decreased phosphorylation of AKT1 protein]
Manganese results in increased phosphorylation of AKT1 protein		 CTD PMID:17043766 PMID:24845367 PMID:31676349 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258 		JBrowse link
G Angpt2 angiopoietin 2 decreases expression EXP Manganese results in decreased expression of ANGPT2 mRNA CTD PMID:26745496 NCBI chr16:75,966,480...76,016,147
Ensembl chr16:75,966,352...76,016,195 		JBrowse link
G Angptl4 angiopoietin-like 4 increases expression ISO Manganese results in increased expression of ANGPTL4 mRNA CTD PMID:17175027 NCBI chr 7:18,627,814...18,634,043
Ensembl chr 7:18,627,808...18,634,079 		JBrowse link
G Ap3b2 adaptor related protein complex 3 subunit beta 2 increases expression ISO Manganese results in increased expression of AP3B2 mRNA CTD PMID:17175027 NCBI chr 1:143,284,041...143,315,846
Ensembl chr 1:143,283,996...143,315,633 		JBrowse link
G App amyloid beta precursor protein increases expression ISO Manganese results in increased expression of APP mRNA CTD PMID:18583042 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858 		JBrowse link
G Aqp4 aquaporin 4 multiple interactions EXP Antioxidants inhibits the reaction [Manganese results in increased expression of AQP4 protein] CTD PMID:20648640 NCBI chr18:6,766,009...6,782,757
Ensembl chr18:6,765,945...6,782,996 		JBrowse link
G Arg1 arginase 1 affects binding ISO
EXP		 Manganese binds to ARG1 protein CTD PMID:15248756 PMID:18802628 NCBI chr 1:21,525,421...21,537,872
Ensembl chr 1:21,525,421...21,537,863 		JBrowse link
G Arhgdia Rho GDP dissociation inhibitor alpha decreases expression ISO Manganese results in decreased expression of ARHGDIA mRNA CTD PMID:17175027 NCBI chr10:109,754,012...109,757,506
Ensembl chr10:109,754,004...109,757,550 		JBrowse link
G Arhgef4 Rho guanine nucleotide exchange factor 4 increases expression ISO Manganese results in increased expression of ARHGEF4 mRNA CTD PMID:17175027 NCBI chr 9:41,160,562...41,305,015
Ensembl chr 9:41,295,909...41,302,501 		JBrowse link
G Atf1 activating transcription factor 1 increases phosphorylation
multiple interactions		 EXP Manganese results in increased phosphorylation of ATF1 protein
SB 203580 inhibits the reaction [Manganese results in increased phosphorylation of ATF1 protein]		 CTD PMID:16787641 NCBI chr 7:141,882,261...141,924,790
Ensembl chr 7:141,882,251...141,924,788 		JBrowse link
G Atf6 activating transcription factor 6 decreases expression ISO Manganese results in decreased expression of ATF6 mRNA CTD PMID:17175027 NCBI chr13:89,053,457...89,242,531
Ensembl chr13:89,055,983...89,242,443 		JBrowse link
G Atm ATM serine/threonine kinase decreases expression ISO Manganese results in decreased expression of ATM mRNA CTD PMID:17175027 NCBI chr 8:58,015,938...58,119,973
Ensembl chr 8:58,015,940...58,120,045 		JBrowse link
G Atoh8 atonal bHLH transcription factor 8 decreases expression EXP Manganese results in decreased expression of ATOH8 mRNA CTD PMID:26745496 NCBI chr 4:100,067,341...100,099,517
Ensembl chr 4:100,067,341...100,099,517 		JBrowse link
G Atp13a2 ATPase cation transporting 13A2 affects response to substance
decreases response to substance		 ISO ATP13A2 gene polymorphism affects the susceptibility to Manganese
ATP13A2 protein results in decreased susceptibility to Manganese		 CTD PMID:22285144 PMID:22847264 NCBI chr 5:159,512,208...159,531,631
Ensembl chr 5:159,512,285...159,531,637 		JBrowse link
G Atp1a3 ATPase Na+/K+ transporting subunit alpha 3 decreases expression
increases methylation		 ISO Manganese results in decreased expression of ATP1A3 mRNA
Manganese results in increased methylation of ATP1A3 promoter		 CTD PMID:23976782 NCBI chr 1:81,852,423...81,881,565
Ensembl chr 1:81,852,429...81,881,549 		JBrowse link
G Atp7a ATPase copper transporting alpha affects localization
decreases expression		 EXP Manganese affects the localization of ATP7A protein
Manganese results in decreased expression of ATP7A mRNA; Manganese results in decreased expression of ATP7A protein		 CTD PMID:24614235 NCBI chr  X:77,076,085...77,193,644
Ensembl chr  X:77,076,106...77,193,644 		JBrowse link
G Atp7b ATPase copper transporting beta increases phosphorylation
decreases expression
affects localization		 ISO
EXP		 Manganese results in increased phosphorylation of ATP7B protein
Manganese results in decreased expression of ATP7B mRNA; Manganese results in decreased expression of ATP7B protein
Manganese affects the localization of ATP7B protein		 CTD PMID:19405516 PMID:24614235 NCBI chr16:74,865,516...74,944,935
Ensembl chr16:74,865,516...74,945,286 		JBrowse link
G Atp8a1 ATPase phospholipid transporting 8A1 decreases expression ISO Manganese results in decreased expression of ATP8A1 mRNA CTD PMID:17175027 NCBI chr14:41,972,398...42,210,555
Ensembl chr14:42,015,347...42,206,311 		JBrowse link
G Bace1 beta-secretase 1 increases expression ISO Manganese results in increased expression of BACE1 mRNA CTD PMID:18583042 NCBI chr 8:50,140,092...50,162,388
Ensembl chr 8:50,139,997...50,162,361 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression		 EXP
ISO		 [manganese chloride results in increased abundance of Manganese] promotes the reaction [Ethanol results in increased expression of BAX protein]; [manganese chloride results in increased abundance of Manganese] which results in increased expression of BAX protein; [Manganese co-treated with NGF protein] results in increased expression of BAX protein; Ethanol promotes the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased expression of BAX protein]; PPM1D protein inhibits the reaction [[Manganese co-treated with NGF protein] results in increased expression of BAX protein]; Rolipram inhibits the reaction [Manganese results in increased expression of BAX protein]
[manganese chloride results in increased abundance of Manganese] which results in increased expression of BAX protein; benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased expression of BAX protein]
NTF3 protein inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased expression of BAX protein]		 CTD PMID:25027559 PMID:25791630 PMID:30844427 PMID:30951808 PMID:31161640 PMID:31676349 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression		 EXP
ISO		 [manganese chloride results in increased abundance of Manganese] promotes the reaction [Ethanol results in decreased expression of BCL2 protein]; [manganese chloride results in increased abundance of Manganese] which results in decreased expression of BCL2 protein; Ethanol promotes the reaction [[manganese chloride results in increased abundance of Manganese] which results in decreased expression of BCL2 protein]; Rolipram inhibits the reaction [Manganese results in decreased expression of BCL2 protein] CTD PMID:30844427 PMID:30951808 PMID:31161640 PMID:31676349 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374 		JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression
multiple interactions		 EXP Manganese results in decreased expression of BCL2L1 protein
[Manganese co-treated with NGF protein] results in decreased expression of BCL2L1 protein; PPM1D protein inhibits the reaction [[Manganese co-treated with NGF protein] results in decreased expression of BCL2L1 protein]		 CTD PMID:25791630 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810 		JBrowse link
G Bdnf brain-derived neurotrophic factor multiple interactions
decreases expression		 EXP
ISO		 [Curcumin co-treated with Manganese] inhibits the reaction [Kainic Acid results in increased expression of BDNF mRNA]; [diacetylcurcumin co-treated with Manganese] inhibits the reaction [Kainic Acid results in increased expression of BDNF mRNA]; [manganese chloride results in increased abundance of Manganese] which results in decreased expression of BDNF protein; [manganese chloride results in increased abundance of Manganese] which results in increased expression of BDNF mRNA; CREB1 protein affects the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased expression of BDNF mRNA]; Rolipram inhibits the reaction [Manganese results in decreased expression of BDNF protein]
Manganese results in decreased expression of BDNF mRNA; Manganese results in decreased expression of BDNF protein		 CTD PMID:17827730 PMID:25099302 PMID:29205667 PMID:30951808 PMID:31161640 PMID:32659473 NCBI chr 3:100,768,637...100,819,216
Ensembl chr 3:100,768,637...100,819,210 		JBrowse link
G Bnip3 BCL2 interacting protein 3 multiple interactions ISO Antioxidants inhibits the reaction [Manganese results in increased expression of BNIP3 protein] CTD PMID:19442826 NCBI chr 1:211,248,098...211,265,282
Ensembl chr 1:211,248,098...211,265,282 		JBrowse link
G Bub1 BUB1 mitotic checkpoint serine/threonine kinase decreases expression ISO Manganese results in decreased expression of BUB1 mRNA CTD PMID:17175027 NCBI chr 3:120,373,604...120,404,910
Ensembl chr 3:120,373,604...120,404,910 		JBrowse link
G Ca8 carbonic anhydrase 8 increases expression EXP Manganese results in increased expression of CAR8 mRNA CTD PMID:26745496 NCBI chr 5:21,249,018...21,345,810
Ensembl chr 5:21,249,020...21,345,810 		JBrowse link
G Calcoco2 calcium binding and coiled-coil domain 2 increases expression ISO Manganese results in increased expression of CALCOCO2 mRNA CTD PMID:17175027 NCBI chr10:83,935,087...83,963,750 JBrowse link
G Calr calreticulin affects expression EXP Manganese affects the expression of CALR protein CTD PMID:24885898 NCBI chr19:25,956,771...25,961,666
Ensembl chr19:25,956,771...25,961,666 		JBrowse link
G Camk2a calcium/calmodulin-dependent protein kinase II alpha decreases phosphorylation EXP Manganese results in decreased phosphorylation of CAMK2A protein CTD PMID:26616912 NCBI chr18:56,193,978...56,295,869
Ensembl chr18:56,193,978...56,295,869 		JBrowse link
G Capn1 calpain 1 increases activity
multiple interactions		 EXP Manganese results in increased activity of CAPN1 protein
calpain inhibitor III inhibits the reaction [Manganese results in increased activity of CAPN1 protein]		 CTD PMID:21985864 NCBI chr 1:221,346,081...221,370,965
Ensembl chr 1:221,346,066...221,370,322 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
increases expression
increases cleavage		 EXP
ISO		 [manganese chloride results in increased abundance of Manganese] promotes the reaction [Ethanol results in increased expression of CASP3 protein]; [manganese chloride results in increased abundance of Manganese] which results in increased cleavage of CASP3 protein; [manganese chloride results in increased abundance of Manganese] which results in increased expression of CASP3 protein; aspartyl-glutamyl-valyl-aspartal inhibits the reaction [Manganese results in increased activity of CASP3 protein]; Deferoxamine inhibits the reaction [Manganese results in increased activity of CASP3 protein]; Ethanol promotes the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased expression of CASP3 protein]; GW 506033X inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased cleavage of CASP3 protein]; Manganese promotes the reaction [SP1 protein modified form binds to CASP3 promoter]; Manganese results in increased expression of and results in increased cleavage of CASP3 protein; pyrazolanthrone inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased cleavage of CASP3 protein]; pyrazolanthrone inhibits the reaction [Manganese results in increased cleavage of CASP3 protein]; pyrazolanthrone inhibits the reaction [Manganese results in increased expression of CASP3 protein]; quinoline-val-asp(OMe)-CH2-OPH inhibits the reaction [Manganese results in increased activity of CASP3 protein]; rhodioloside inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased cleavage of CASP3 protein]; U 0126 inhibits the reaction [Manganese results in increased expression of CASP3 mRNA]; U 0126 inhibits the reaction [Manganese results in increased expression of CASP3 protein]
SNCA protein inhibits the reaction [Manganese results in increased activity of CASP3 protein]
Manganese results in increased expression of CASP3 mRNA; Manganese results in increased expression of CASP3 protein		 CTD PMID:11933051 PMID:16787641 PMID:21985864 PMID:22427945 PMID:22841634 PMID:22975163 PMID:25027559 PMID:25416158 PMID:30844427 PMID:30991096 PMID:31161640 PMID:31676349 PMID:32574669 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204 		JBrowse link
G Casp7 caspase 7 increases activity EXP Manganese results in increased activity of CASP7 protein CTD PMID:22427945 NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774 		JBrowse link
G Casp8 caspase 8 increases activity
multiple interactions		 EXP Manganese results in increased activity of CASP8 protein
Rolipram inhibits the reaction [Manganese results in increased activity of CASP8 protein]		 CTD PMID:31161640 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106 		JBrowse link
G Casp9 caspase 9 increases cleavage
increases activity
multiple interactions		 EXP
ISO		 Manganese results in increased cleavage of CASP9 protein
Manganese results in increased activity of CASP9 protein
SNCA protein inhibits the reaction [Manganese results in increased activity of CASP9 protein]		 CTD PMID:16787641 PMID:25416158 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778 		JBrowse link
G Cat catalase multiple interactions
decreases activity		 ISO
EXP		 [manganese chloride results in increased abundance of Manganese] which results in decreased activity of CAT protein; CAT protein inhibits the reaction [[[PRNP protein binds to Manganese] which co-treated with Hydrogen Peroxide] results in increased cleavage of [PRNP protein binds to PRNP protein]]
Manganese results in decreased activity of CAT protein
[Arsenic co-treated with Cadmium co-treated with Lead co-treated with Mercury co-treated with Chromium co-treated with Nickel co-treated with Manganese co-treated with Iron] results in decreased activity of CAT protein; [manganese chloride results in increased abundance of Manganese] promotes the reaction [Ethanol results in decreased activity of CAT protein]; [manganese chloride results in increased abundance of Manganese] which results in decreased activity of CAT protein; CAT protein inhibits the reaction [Manganese results in increased expression of SLC12A2 protein]; CAT protein inhibits the reaction [Manganese results in increased phosphorylation of and results in increased activity of SLC12A2 protein]; Ethanol promotes the reaction [[manganese chloride results in increased abundance of Manganese] which results in decreased activity of CAT protein]; Silymarin inhibits the reaction [Manganese results in decreased activity of CAT protein]		 CTD PMID:16595185 PMID:17176674 PMID:23339144 PMID:25817889 PMID:30844427 PMID:32445656 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058 		JBrowse link
G Cav1 caveolin 1 decreases expression ISO Manganese results in decreased expression of CAV1 mRNA; Manganese results in decreased expression of CAV1 protein CTD PMID:23499988 PMID:23597857 NCBI chr 4:44,597,123...44,630,206
Ensembl chr 4:44,597,123...44,630,200 		JBrowse link
G Cav3 caveolin 3 decreases expression ISO Manganese results in decreased expression of CAV3 mRNA; Manganese results in decreased expression of CAV3 protein CTD PMID:23597857 NCBI chr 4:144,382,945...144,398,919
Ensembl chr 4:144,382,945...144,398,917 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases expression EXP Manganese results in increased expression of CCL2 mRNA CTD PMID:19782702 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870 		JBrowse link
G Ccl7 C-C motif chemokine ligand 7 increases expression ISO Manganese results in increased expression of CCL7 mRNA CTD PMID:17175027 NCBI chr10:69,423,083...69,424,933
Ensembl chr10:69,423,086...69,424,979 		JBrowse link
G Ccna1 cyclin A1 increases expression EXP Manganese results in increased expression of CCNA1 mRNA CTD PMID:26745496 NCBI chr 2:144,456,689...144,503,570
Ensembl chr 2:144,458,153...144,467,912 		JBrowse link
G Ccnb2 cyclin B2 decreases expression ISO Manganese results in decreased expression of CCNB2 mRNA CTD PMID:17175027 NCBI chr 8:76,847,972...76,861,165 JBrowse link
G Ccnd1 cyclin D1 increases expression EXP Manganese results in increased expression of CCND1 mRNA CTD PMID:23997110 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325 		JBrowse link
G Cd48 Cd48 molecule increases expression ISO Manganese results in increased expression of CD48 mRNA CTD PMID:17175027 NCBI chr13:90,116,601...90,140,371
Ensembl chr13:90,116,843...90,140,371 		JBrowse link
G Cd8b CD8b molecule increases expression ISO Manganese results in increased expression of CD8B mRNA; Manganese results in increased expression of CD8B1 mRNA CTD PMID:17175027 NCBI chr 4:99,185,960...99,201,887
Ensembl chr 4:99,185,885...99,202,023 		JBrowse link
G Cdkn2c cyclin-dependent kinase inhibitor 2C decreases expression ISO Manganese results in decreased expression of CDKN2C mRNA CTD PMID:17175027 NCBI chr 5:129,347,731...129,352,886
Ensembl chr 5:129,347,732...129,352,886 		JBrowse link
G Cdkn3 cyclin-dependent kinase inhibitor 3 decreases expression ISO Manganese results in decreased expression of CDKN3 mRNA CTD PMID:17175027 NCBI chr15:23,553,171...23,564,538
Ensembl chr15:23,553,128...23,564,535 		JBrowse link
G Cebpd CCAAT/enhancer binding protein delta increases expression ISO Manganese results in increased expression of CEBPD mRNA CTD PMID:17175027 NCBI chr11:89,008,008...89,009,146
Ensembl chr11:89,008,008...89,009,146 		JBrowse link
G Celsr1 cadherin, EGF LAG seven-pass G-type receptor 1 increases expression ISO Manganese results in increased expression of CELSR1 mRNA CTD PMID:17175027 NCBI chr 7:126,774,010...126,914,085
Ensembl chr 7:126,775,516...126,913,585 		JBrowse link
G Cep128 centrosomal protein 128 decreases expression ISO Manganese results in decreased expression of CEP128 mRNA CTD PMID:17175027 NCBI chr 6:114,759,474...115,158,004
Ensembl chr 6:114,759,474...115,157,854 		JBrowse link
G Chat choline O-acetyltransferase decreases activity
multiple interactions		 EXP
ISO		 Manganese results in decreased activity of CHAT protein
[manganese chloride results in increased abundance of Manganese] which results in decreased activity of CHAT protein
Taurine inhibits the reaction [Manganese results in decreased activity of CHAT protein]		 CTD PMID:24885898 PMID:30738988 NCBI chr16:8,576,858...8,686,131
Ensembl chr16:8,577,840...8,686,131 		JBrowse link
G Cks2 CDC28 protein kinase regulatory subunit 2 decreases expression ISO Manganese results in decreased expression of CKS2 mRNA CTD PMID:17175027 NCBI chr17:13,587,664...13,593,423
Ensembl chr17:13,587,665...13,593,423 		JBrowse link
G Cldn23 claudin 23 increases expression EXP Manganese results in increased expression of CLDN23 mRNA CTD PMID:26745496 NCBI chr16:59,988,603...59,990,327
Ensembl chr16:59,988,603...59,990,326 		JBrowse link
G Cln6 CLN6, transmembrane ER protein increases abundance ISO CLN6 gene mutant form results in increased abundance of Manganese CTD PMID:23789114 NCBI chr 8:67,733,215...67,748,170
Ensembl chr 8:67,733,215...67,748,172 		JBrowse link
G Cnot2 CCR4-NOT transcription complex, subunit 2 decreases expression ISO Manganese results in decreased expression of CNOT2 mRNA CTD PMID:17175027 NCBI chr 7:59,526,105...59,617,307
Ensembl chr 7:59,527,124...59,587,385 		JBrowse link
G Cnot6l CCR4-NOT transcription complex, subunit 6-like increases expression ISO Manganese results in increased expression of CNOT6L mRNA CTD PMID:17175027 NCBI chr14:15,059,101...15,148,255
Ensembl chr14:15,059,387...15,146,586 		JBrowse link
G Col12a1 collagen type XII alpha 1 chain decreases expression ISO Manganese results in decreased expression of COL12A1 mRNA CTD PMID:17175027 NCBI chr 8:87,042,820...87,150,701
Ensembl chr 8:87,040,799...87,158,368 		JBrowse link
G Cpm carboxypeptidase M decreases expression ISO Manganese results in decreased expression of CPM mRNA CTD PMID:17175027 NCBI chr 7:60,654,350...60,714,620
Ensembl chr 7:60,654,350...60,714,620 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 increases phosphorylation
decreases phosphorylation
multiple interactions
decreases expression		 EXP
ISO		 Manganese results in increased phosphorylation of CREB1 protein
Manganese results in decreased phosphorylation of CREB1 protein
[manganese chloride results in increased abundance of Manganese] which results in decreased expression of CREB1 protein; NTF3 protein inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in decreased phosphorylation of CREB1 protein]
[manganese chloride results in increased abundance of Manganese] which results in decreased phosphorylation of CREB1 protein; [manganese chloride results in increased abundance of Manganese] which results in increased phosphorylation of CREB1 protein; benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in decreased phosphorylation of CREB1 protein]
Manganese results in decreased expression of CREB1 mRNA; Manganese results in decreased expression of CREB1 protein
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased phosphorylation of CREB1 protein]; [manganese chloride results in increased abundance of Manganese] which results in increased phosphorylation of CREB1 protein; CREB1 protein affects the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased expression of BDNF mRNA]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased phosphorylation of CREB1 protein]; Rolipram inhibits the reaction [Manganese results in decreased phosphorylation of CREB1 protein]; SB 203580 inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased phosphorylation of CREB1 protein]; SB 203580 inhibits the reaction [Manganese results in increased phosphorylation of CREB1 protein]		 CTD PMID:16787641 PMID:29205667 PMID:30951808 PMID:31161640 PMID:31676349 PMID:32659473 NCBI chr 9:71,229,753...71,298,994
Ensembl chr 9:71,230,108...71,293,435 		JBrowse link
G Crh corticotropin releasing hormone multiple interactions EXP CRH protein inhibits the reaction [Manganese results in increased chemical synthesis of Cyclic AMP] CTD PMID:2153673 NCBI chr 2:104,459,999...104,461,863
Ensembl chr 2:104,459,999...104,461,863 		JBrowse link
G Crym crystallin, mu affects expression EXP Manganese affects the expression of CRYM protein CTD PMID:24885898 NCBI chr 1:189,944,895...189,960,069
Ensembl chr 1:189,944,895...189,960,073 		JBrowse link
G Csrp3 cysteine and glycine rich protein 3 increases expression EXP Manganese results in increased expression of CSRP3 mRNA CTD PMID:26745496 NCBI chr 1:104,147,205...104,166,389
Ensembl chr 1:104,147,206...104,166,367 		JBrowse link
G Ctnna1 catenin alpha 1 decreases expression ISO Manganese results in decreased expression of CTNNA1 mRNA CTD PMID:17175027 NCBI chr18:27,923,229...28,055,972
Ensembl chr18:27,923,572...28,055,960 		JBrowse link
G Ctnnb1 catenin beta 1 decreases expression ISO Manganese results in decreased expression of CTNNB1 mRNA CTD PMID:17175027 NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372 		JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 decreases expression ISO Manganese results in decreased expression of CXCL12 mRNA CTD PMID:23499988 NCBI chr 4:149,261,044...149,273,891
Ensembl chr 4:149,261,044...149,273,891 		JBrowse link
G Cxcl14 C-X-C motif chemokine ligand 14 increases expression ISO Manganese results in increased expression of CXCL14 mRNA CTD PMID:17175027 NCBI chr17:9,109,731...9,117,754
Ensembl chr17:9,109,731...9,117,750 		JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 increases expression ISO
EXP		 Manganese results in increased expression of CXCL2 mRNA CTD PMID:17175027 PMID:19782702 PMID:20224926 NCBI chr14:18,731,346...18,733,391
Ensembl chr14:18,731,378...18,733,391 		JBrowse link
G Cxcl6 C-X-C motif chemokine ligand 6 increases expression ISO Manganese results in increased expression of CXCL6 mRNA CTD PMID:17175027 NCBI chr14:18,860,201...18,920,839
Ensembl chr14:18,860,264...18,862,407 		JBrowse link
G Cycs cytochrome c, somatic multiple interactions
affects localization		 ISO
EXP		 SNCA protein inhibits the reaction [Manganese affects the localization of CYCS protein] CTD PMID:25416158 NCBI chr 4:80,331,226...80,333,326
Ensembl chr 4:80,331,227...80,333,326 		JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 decreases expression EXP Manganese results in decreased expression of CYP11A1 protein CTD PMID:25981801 NCBI chr 8:62,798,317...62,809,848
Ensembl chr 8:62,779,875...62,809,893 		JBrowse link
G Cyp26b1 cytochrome P450, family 26, subfamily b, polypeptide 1 decreases expression EXP Manganese results in decreased expression of CYP26B1 mRNA CTD PMID:26745496 NCBI chr 4:116,261,796...116,278,615
Ensembl chr 4:116,261,796...116,278,615 		JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 decreases response to substance ISO CYP2D6 gene polymorphism results in decreased susceptibility to Manganese CTD PMID:12171760 NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436 		JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 multiple interactions
increases activity		 EXP [Manganese co-treated with Bilirubin] results in decreased activity of CYP7A1 protein
Manganese results in increased activity of CYP7A1 protein		 CTD PMID:12700418 NCBI chr 5:19,358,734...19,368,431
Ensembl chr 5:19,358,734...19,368,431 		JBrowse link
G Dach2 dachshund family transcription factor 2 increases expression ISO Manganese results in increased expression of DACH2 mRNA CTD PMID:17175027 NCBI chr  X:84,924,570...85,484,150
Ensembl chr  X:85,338,928...85,483,719 		JBrowse link
G Dctn3 dynactin subunit 3 affects expression EXP Manganese affects the expression of DCTN3 protein CTD PMID:24885898 NCBI chr 5:58,098,706...58,106,706
Ensembl chr 5:58,098,706...58,106,706 		JBrowse link
G Ddah1 dimethylarginine dimethylaminohydrolase 1 decreases expression
multiple interactions		 ISO Manganese deficiency results in decreased expression of DDAH1 protein
Paroxetine inhibits the reaction [Manganese deficiency results in decreased expression of DDAH1 protein]		 CTD PMID:21312047 NCBI chr 2:251,634,368...251,766,009
Ensembl chr 2:251,634,431...251,766,014 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression
multiple interactions		 ISO
EXP		 Manganese results in increased expression of DDIT3 protein
[manganese chloride results in increased abundance of Manganese] which results in increased expression of DDIT3 mRNA
Manganese results in increased expression of DDIT3 mRNA		 CTD PMID:21477646 PMID:23499988 PMID:32574669 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084 		JBrowse link
G Dld dihydrolipoamide dehydrogenase decreases expression EXP Manganese results in decreased expression of DLD protein CTD PMID:25981801 NCBI chr 6:50,597,677...50,618,694
Ensembl chr 6:50,597,677...50,618,694 		JBrowse link
G Dnah14 dynein axonemal heavy chain 14 decreases expression ISO Manganese results in decreased expression of DNAH14 mRNA CTD PMID:17175027 NCBI chr13:99,886,373...100,072,674
NCBI chr13:101,936,210...101,973,640 		JBrowse link
G Dnph1 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 decreases expression ISO Manganese results in decreased expression of DNPH1 mRNA CTD PMID:17175027 NCBI chr 9:16,845,764...16,848,514
Ensembl chr 9:16,845,525...16,848,503 		JBrowse link
G Dpp4 dipeptidylpeptidase 4 increases expression ISO Manganese results in increased expression of DPP4 mRNA CTD PMID:17175027 NCBI chr 3:48,291,055...48,372,672
Ensembl chr 3:48,291,055...48,372,672 		JBrowse link
G Dr1 down-regulator of transcription 1 decreases expression ISO Manganese results in decreased expression of DR1 mRNA CTD PMID:17175027 NCBI chr14:2,463,651...2,475,004
Ensembl chr14:2,463,643...2,474,780 		JBrowse link
G Drd2 dopamine receptor D2 decreases expression EXP Manganese results in decreased expression of DRD2 mRNA CTD PMID:20224926 NCBI chr 8:53,678,777...53,743,643
Ensembl chr 8:53,678,777...53,743,642 		JBrowse link
G Dscaml1 DS cell adhesion molecule-like 1 increases expression EXP Manganese results in increased expression of DSCAML1 mRNA CTD PMID:26745496 NCBI chr 8:49,733,835...50,056,115
Ensembl chr 8:49,737,798...50,055,560 		JBrowse link
G Dspp dentin sialophosphoprotein increases expression ISO Manganese results in increased expression of DSPP mRNA CTD PMID:17175027 NCBI chr14:6,926,972...6,933,079
Ensembl chr14:6,926,976...6,933,070 		JBrowse link
G Dusp1 dual specificity phosphatase 1 multiple interactions
decreases expression		 ISO [Manganese co-treated with Lipopolysaccharides] results in decreased expression of DUSP1 mRNA; [Manganese co-treated with Lipopolysaccharides] results in decreased expression of DUSP1 protein
Manganese results in decreased expression of DUSP1 mRNA; Manganese results in decreased expression of DUSP1 protein		 CTD PMID:20589745 NCBI chr10:16,970,642...16,973,425
Ensembl chr10:16,970,626...16,973,418 		JBrowse link
G Eif2a eukaryotic translation initiation factor 2A increases expression ISO Manganese results in increased expression of EIF2A protein CTD PMID:21477646 NCBI chr 2:148,722,343...148,755,781
Ensembl chr 2:148,722,231...148,755,520 		JBrowse link
G Eif2ak2 eukaryotic translation initiation factor 2-alpha kinase 2 multiple interactions EXP [manganese chloride results in increased abundance of Manganese] which results in increased cleavage of EIF2AK2 protein; GW 506033X inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased cleavage of EIF2AK2 protein]; pyrazolanthrone inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased cleavage of EIF2AK2 protein] CTD PMID:32574669 NCBI chr 6:1,428,845...1,466,193
Ensembl chr 6:1,428,834...1,466,201 		JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 multiple interactions EXP [manganese chloride results in increased abundance of Manganese] which results in increased phosphorylation of EIF2AK3 protein CTD PMID:32574669 NCBI chr 4:98,648,513...98,709,695
Ensembl chr 4:98,648,545...98,709,694 		JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha multiple interactions EXP [manganese chloride results in increased abundance of Manganese] which results in increased phosphorylation of EIF2S1 protein CTD PMID:32574669 NCBI chr 6:102,048,372...102,073,041
Ensembl chr 6:102,048,372...102,073,041 		JBrowse link
G Elf1 E74 like ETS transcription factor 1 decreases expression ISO Manganese results in decreased expression of ELF1 mRNA CTD PMID:17175027 NCBI chr15:61,772,544...61,868,442
Ensembl chr15:61,826,711...61,868,343 		JBrowse link
G Eml2 EMAP like 2 increases expression ISO Manganese results in increased expression of EML2 mRNA CTD PMID:17175027 NCBI chr 1:80,087,684...80,118,784
Ensembl chr 1:80,087,684...80,119,012 		JBrowse link
G Eno1 enolase 1 decreases activity ISO Manganese results in decreased activity of ENO1 protein CTD PMID:22191580 NCBI chr 5:167,288,223...167,299,610
Ensembl chr 5:167,288,223...167,299,609 		JBrowse link
G Epo erythropoietin increases glycosylation ISO Manganese results in increased glycosylation of EPO protein CTD PMID:16937399 NCBI chr12:22,274,828...22,278,268
Ensembl chr12:22,274,828...22,278,266 		JBrowse link
G Ercc6l ERCC excision repair 6 like, spindle assembly checkpoint helicase decreases expression ISO Manganese results in decreased expression of ERCC6L mRNA CTD PMID:17175027 NCBI chr  X:72,018,373...72,034,140
Ensembl chr  X:72,018,373...72,034,099 		JBrowse link
G Ereg epiregulin increases expression ISO Manganese results in increased expression of EREG mRNA CTD PMID:17175027 NCBI chr14:18,577,620...18,591,395
Ensembl chr14:18,576,355...18,591,394 		JBrowse link
G Erich1 glutamate-rich 1 increases expression ISO Manganese results in increased expression of ERICH1 mRNA CTD PMID:17175027 NCBI chr16:80,601,873...80,667,774
Ensembl chr16:80,601,973...80,667,781 		JBrowse link
G Esr1 estrogen receptor 1 increases expression EXP Manganese results in increased expression of ESR1 protein CTD PMID:24845367 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796 		JBrowse link
G Exoc6 exocyst complex component 6 decreases expression ISO Manganese results in decreased expression of EXOC6 mRNA CTD PMID:17175027 NCBI chr 1:256,211,879...256,369,318
Ensembl chr 1:256,226,179...256,368,813 		JBrowse link
G Eya4 EYA transcriptional coactivator and phosphatase 4 decreases expression ISO Manganese results in decreased expression of EYA4 mRNA CTD PMID:17175027 NCBI chr 1:23,237,617...23,611,580
Ensembl chr 1:23,409,408...23,610,164 		JBrowse link
G F2 coagulation factor II multiple interactions
increases uptake		 ISO 1-Methyl-3-isobutylxanthine inhibits the reaction [F2 protein results in increased uptake of Manganese]; Colforsin inhibits the reaction [F2 protein results in increased uptake of Manganese]; Nickel inhibits the reaction [F2 protein results in increased uptake of Manganese]; Tetradecanoylphorbol Acetate inhibits the reaction [F2 protein results in increased uptake of Manganese] CTD PMID:2125206 NCBI chr 3:80,529,468...80,542,993
Ensembl chr 3:80,529,428...80,543,031 		JBrowse link
G Fa2h fatty acid 2-hydroxylase increases expression EXP Manganese results in increased expression of FA2H mRNA CTD PMID:26745496 NCBI chr19:43,545,380...43,596,788
Ensembl chr19:43,545,378...43,596,801 		JBrowse link
G Fam107a family with sequence similarity 107, member A decreases expression EXP Manganese results in decreased expression of FAM107A mRNA CTD PMID:26745496 NCBI chr15:18,399,145...18,415,959
Ensembl chr15:18,399,515...18,415,965 		JBrowse link
G Fam180a family with sequence similarity 180, member A decreases expression EXP Manganese results in decreased expression of FAM180A mRNA CTD PMID:26745496 NCBI chr 4:62,845,054...62,860,361
Ensembl chr 4:62,844,971...62,860,446 		JBrowse link
G Fancf FA complementation group F decreases expression ISO Manganese results in decreased expression of FANCF mRNA CTD PMID:17175027 NCBI chr 1:107,229,516...107,232,321
Ensembl chr 1:107,231,292...107,232,305 		JBrowse link
G Fcgr1a Fc fragment of IgG receptor Ia decreases expression EXP Manganese results in decreased expression of FCGR1A mRNA CTD PMID:26745496 NCBI chr 2:198,430,536...198,439,453
Ensembl chr 2:198,430,530...198,458,041 		JBrowse link
G Fgfbp1 fibroblast growth factor binding protein 1 decreases expression EXP Manganese results in decreased expression of FGFBP1 mRNA CTD PMID:26745496 NCBI chr14:71,647,429...71,650,359
Ensembl chr14:71,649,274...71,650,354 		JBrowse link
G Fhl1 four and a half LIM domains 1 decreases expression ISO Manganese results in decreased expression of FHL1 mRNA CTD PMID:17175027 NCBI chr  X:159,112,516...159,172,528
Ensembl chr  X:159,112,880...159,172,524 		JBrowse link
G Fibin fin bud initiation factor homolog increases expression ISO Manganese results in increased expression of FIBIN mRNA CTD PMID:21615908 NCBI chr 3:101,545,207...101,547,478
Ensembl chr 3:101,545,208...101,547,478 		JBrowse link
G Flcn folliculin increases expression ISO Manganese results in increased expression of FLCN mRNA CTD PMID:17175027 NCBI chr10:46,153,185...46,172,331
Ensembl chr10:46,153,188...46,172,309 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions
decreases expression		 EXP
ISO		 [Curcumin co-treated with Manganese] inhibits the reaction [Kainic Acid results in increased expression of FOS protein]; [diacetylcurcumin co-treated with Manganese] inhibits the reaction [Kainic Acid results in increased expression of FOS protein]
Manganese promotes the reaction [Tetradecanoylphorbol Acetate results in increased activity of [JUN protein binds to FOS protein]]; Manganese promotes the reaction [Tetradecanoylphorbol Acetate results in increased expression of FOS protein]
Manganese results in decreased expression of FOS protein		 CTD PMID:17043766 PMID:17827730 PMID:22561169 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299 		JBrowse link
G Foxn4 forkhead box N4 increases expression EXP Manganese results in increased expression of FOXN4 mRNA CTD PMID:26745496 NCBI chr12:48,101,012...48,121,281
Ensembl chr12:48,101,673...48,121,270 		JBrowse link
G Foxo3 forkhead box O3 multiple interactions
affects localization		 EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Manganese results in increased phosphorylation of FOXO3 protein]; 2-oxothiazolidine-4-carboxylic acid inhibits the reaction [Manganese affects the localization of FOXO3 protein]; 2-oxothiazolidine-4-carboxylic acid inhibits the reaction [Manganese results in increased expression of FOXO3 protein]; Manganese results in increased expression of and results in increased phosphorylation of FOXO3 protein; SB 203580 inhibits the reaction [Manganese results in increased phosphorylation of FOXO3 protein] CTD PMID:24787138 NCBI chr20:46,428,078...46,519,156
Ensembl chr20:46,428,124...46,519,144 		JBrowse link
G Foxp2 forkhead box P2 increases expression ISO Manganese results in increased expression of FOXP2 mRNA CTD PMID:17175027 NCBI chr 4:41,364,441...41,944,685
Ensembl chr 4:41,364,441...41,942,023 		JBrowse link
G Fth1 ferritin heavy chain 1 decreases expression
increases expression		 EXP Manganese results in decreased expression of FTH1 mRNA; Manganese results in decreased expression of FTH1 protein
Manganese results in increased expression of FTH1 protein		 CTD PMID:16545456 PMID:16568477 PMID:16740617 PMID:17469137 NCBI chr 1:226,030,940...226,033,228
Ensembl chr 1:226,030,938...226,033,228 		JBrowse link
G Fxyd2 FXYD domain-containing ion transport regulator 2 increases expression ISO Manganese results in increased expression of FXYD2 mRNA CTD PMID:17175027 NCBI chr 8:49,710,334...49,717,492
Ensembl chr 8:49,710,477...49,716,955 		JBrowse link
G Gabbr2 gamma-aminobutyric acid type B receptor subunit 2 multiple interactions ISO [manganese chloride results in increased abundance of Manganese] which results in increased expression of GABBR2 protein CTD PMID:32659473 NCBI chr 5:62,276,100...62,621,737
Ensembl chr 5:62,276,100...62,621,737 		JBrowse link
G Gabra1 gamma-aminobutyric acid type A receptor subunit alpha 1 multiple interactions ISO [manganese chloride results in increased abundance of Manganese] which results in decreased expression of GABRA1 protein CTD PMID:32659473 NCBI chr10:27,310,718...27,371,802
Ensembl chr10:27,310,725...27,366,665 		JBrowse link
G Gabrg2 gamma-aminobutyric acid type A receptor subunit gamma 2 increases expression ISO Manganese results in increased expression of GABRG2 mRNA CTD PMID:17175027 NCBI chr10:27,090,913...27,179,786
Ensembl chr10:27,092,827...27,179,900 		JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha increases expression ISO Manganese results in increased expression of GADD45A mRNA CTD PMID:23499988 NCBI chr 4:97,782,512...97,784,814
Ensembl chr 4:97,782,512...97,784,842 		JBrowse link
G Gal galanin and GMAP prepropeptide increases expression ISO Manganese results in increased expression of GAL mRNA CTD PMID:17175027 NCBI chr 1:218,653,059...218,657,922
Ensembl chr 1:218,652,917...218,657,925 		JBrowse link
G Gcfc2 GC-rich sequence DNA-binding factor 2 decreases expression ISO Manganese results in decreased expression of GCFC2 mRNA CTD PMID:17175027 NCBI chr 4:112,662,556...112,700,505
Ensembl chr 4:112,662,609...112,699,711 		JBrowse link
G Gdap2 ganglioside-induced differentiation-associated-protein 2 increases expression ISO Manganese results in increased expression of GDAP2 mRNA CTD PMID:17175027 NCBI chr 2:202,470,485...202,526,849
Ensembl chr 2:202,470,487...202,526,849 		JBrowse link
G Gdf15 growth differentiation factor 15 increases expression ISO Manganese results in increased expression of GDF15 mRNA CTD PMID:17175027 NCBI chr16:20,555,395...20,557,978
Ensembl chr16:20,555,395...20,557,978 		JBrowse link
G Gfap glial fibrillary acidic protein decreases expression
affects expression
increases expression		 EXP
ISO		 Manganese results in decreased expression of GFAP mRNA
Manganese affects the expression of GFAP protein
Manganese results in increased expression of GFAP mRNA; Manganese results in increased expression of GFAP protein		 CTD PMID:19782702 PMID:20224926 PMID:23832297 PMID:24885898 NCBI chr10:90,990,762...90,999,435
Ensembl chr10:90,990,762...90,999,506 		JBrowse link
G Gja5 gap junction protein, alpha 5 decreases expression EXP Manganese results in decreased expression of GJA5 mRNA CTD PMID:26745496 NCBI chr 2:199,162,745...199,184,942
Ensembl chr 2:199,162,745...199,184,939 		JBrowse link
G Gldn gliomedin decreases expression EXP Manganese results in decreased expression of GLDN mRNA CTD PMID:26745496 NCBI chr 8:58,870,516...58,914,605
Ensembl chr 8:58,870,516...58,914,603 		JBrowse link
G Glud1 glutamate dehydrogenase 1 decreases expression
multiple interactions		 ISO Manganese deficiency results in decreased expression of GLUD1 protein
Paroxetine inhibits the reaction [Manganese deficiency results in decreased expression of GLUD1 protein]		 CTD PMID:21312047 NCBI chr16:10,661,486...10,695,557
Ensembl chr16:10,662,021...10,695,557 		JBrowse link
G Glul glutamate-ammonia ligase affects expression
decreases expression		 EXP Manganese affects the expression of GLUL mRNA; Manganese affects the expression of GLUL protein
Manganese results in decreased expression of GLUL mRNA; Manganese results in decreased expression of GLUL protein		 CTD PMID:16842851 PMID:16943606 NCBI chr13:71,331,052...71,340,207
Ensembl chr13:71,331,052...71,340,229 		JBrowse link
G Gnrh1 gonadotropin releasing hormone 1 increases expression EXP Manganese results in increased expression of GNRH1 mRNA CTD PMID:23997110 NCBI chr15:44,441,856...44,446,064
Ensembl chr15:44,442,555...44,442,875
Ensembl chr15:44,442,555...44,442,875 		JBrowse link
G Gper1 G protein-coupled estrogen receptor 1 multiple interactions EXP [1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone binds to and results in increased activity of GPER1 protein] which results in decreased susceptibility to Manganese CTD PMID:22645130 NCBI chr12:17,309,122...17,315,267
Ensembl chr12:17,309,834...17,311,112 		JBrowse link
G Gpr18 G protein-coupled receptor 18 decreases expression EXP Manganese results in decreased expression of GPR18 mRNA CTD PMID:26745496 NCBI chr15:108,323,157...108,326,907
Ensembl chr15:108,323,179...108,326,907 		JBrowse link
G Gpr34 G protein-coupled receptor 34 decreases expression EXP Manganese results in decreased expression of GPR34 mRNA CTD PMID:26745496 NCBI chr  X:10,022,986...10,043,504
Ensembl chr  X:10,023,489...10,031,167 		JBrowse link
G Grin1 glutamate ionotropic receptor NMDA type subunit 1 decreases expression EXP Manganese results in decreased expression of GRIN1 mRNA; Manganese results in decreased expression of GRIN1 protein CTD PMID:19643132 PMID:29205667 NCBI chr 3:2,507,745...2,534,664
Ensembl chr 3:2,506,896...2,534,663 		JBrowse link
G Grin2a glutamate ionotropic receptor NMDA type subunit 2A decreases expression EXP Manganese results in decreased expression of GRIN2A mRNA; Manganese results in decreased expression of GRIN2A protein CTD PMID:19643132 PMID:29205667 NCBI chr10:5,707,806...6,123,568
Ensembl chr10:5,930,298...6,119,990 		JBrowse link
G Grin2b glutamate ionotropic receptor NMDA type subunit 2B decreases expression EXP Manganese results in decreased expression of GRIN2B mRNA; Manganese results in decreased expression of GRIN2B protein CTD PMID:19643132 PMID:29205667 NCBI chr 4:169,541,620...170,000,216
Ensembl chr 4:169,560,387...169,999,873 		JBrowse link
G Gsr glutathione-disulfide reductase decreases expression
multiple interactions		 ISO
EXP		 Manganese results in decreased expression of GSR mRNA
[manganese chloride results in increased abundance of Manganese] which results in decreased activity of GSR protein
[Arsenic co-treated with Cadmium co-treated with Lead co-treated with Mercury co-treated with Chromium co-treated with Nickel co-treated with Manganese co-treated with Iron] results in decreased activity of GSR protein		 CTD PMID:17175027 PMID:17176674 PMID:32445656 NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 affects response to substance ISO GSTP1 gene polymorphism affects the susceptibility to Manganese CTD PMID:30930959 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147 		JBrowse link
G Gtf2h1 general transcription factor IIH subunit 1 decreases expression ISO Manganese results in decreased expression of GTF2H1 mRNA CTD PMID:17175027 NCBI chr 1:102,849,618...102,877,939
Ensembl chr 1:102,849,889...102,877,944 		JBrowse link
G Gucy1a1 guanylate cyclase 1 soluble subunit alpha 1 multiple interactions ISO Manganese results in increased activity of [GUCY1A1 protein binds to GUCY1B1 protein] CTD PMID:22171090 NCBI chr 2:181,045,694...181,103,321
Ensembl chr 2:181,045,703...181,102,918 		JBrowse link
G Gucy1b1 guanylate cyclase 1 soluble subunit beta 1 multiple interactions ISO Manganese results in increased activity of [GUCY1A1 protein binds to GUCY1B1 protein] CTD PMID:22171090 NCBI chr 2:180,976,939...181,026,001
Ensembl chr 2:180,976,939...181,026,024 		JBrowse link
G Hamp hepcidin antimicrobial peptide decreases expression ISO Manganese results in decreased expression of HAMP mRNA CTD PMID:29020610 NCBI chr 1:89,368,021...89,369,960
Ensembl chr 1:89,368,021...89,369,960 		JBrowse link
G Hdac1 histone deacetylase 1 multiple interactions EXP Manganese promotes the reaction [RELA protein binds to HDAC1 protein]; Manganese promotes the reaction [YY1 protein binds to HDAC1 protein] CTD PMID:24469401 NCBI chr 5:147,716,664...147,743,723
Ensembl chr 5:147,716,664...147,743,723 		JBrowse link
G Heph hephaestin increases expression ISO Manganese results in increased expression of HEPH mRNA CTD PMID:17175027 NCBI chr  X:65,377,313...65,658,479
Ensembl chr  X:65,563,122...65,658,516 		JBrowse link
G Hfe homeostatic iron regulator affects abundance ISO HFE protein affects the abundance of Manganese CTD PMID:18317567 NCBI chr17:43,661,276...43,669,327
Ensembl chr17:43,661,222...43,669,985 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions
increases expression		 ISO Manganese results in increased expression of and results in increased activity of HIF1A protein
Manganese results in increased expression of HIF1A mRNA		 CTD PMID:16386771 PMID:17175027 NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052 		JBrowse link
G Hif1an hypoxia inducible factor 1 subunit alpha inhibitor decreases expression ISO Manganese results in decreased expression of HIF1AN mRNA CTD PMID:17175027 NCBI chr 1:264,309,214...264,319,269
Ensembl chr 1:264,309,214...264,319,267 		JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase multiple interactions
increases activity		 EXP [Manganese co-treated with Bilirubin] results in decreased activity of HMGCR protein
Manganese results in increased activity of HMGCR protein		 CTD PMID:12700418 NCBI chr 2:27,480,224...27,500,654
Ensembl chr 2:27,480,226...27,500,654 		JBrowse link
G Hmgcs2 3-hydroxy-3-methylglutaryl-CoA synthase 2 decreases expression EXP Manganese results in decreased expression of HMGCS2 mRNA CTD PMID:26745496 NCBI chr 2:200,452,623...200,480,785
Ensembl chr 2:200,452,624...200,479,423 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression
multiple interactions		 ISO
EXP		 Manganese results in increased expression of HMOX1 mRNA
[manganese chloride results in increased abundance of Manganese] which results in increased expression of HMOX1 protein; GW 506033X promotes the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased expression of HMOX1 protein]		 CTD PMID:11181820 PMID:18948096 PMID:23832297 PMID:32574669 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456 		JBrowse link
G Hoxb9 homeo box B9 decreases expression ISO Manganese results in decreased expression of HOXB9 mRNA CTD PMID:17175027 NCBI chr10:84,119,772...84,124,963
Ensembl chr10:84,119,884...84,123,390 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression
multiple interactions		 ISO
EXP		 Manganese results in increased expression of HSPA5 protein
[manganese chloride results in increased abundance of Manganese] which results in increased expression of HSPA5 mRNA		 CTD PMID:21477646 PMID:32574669 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762 		JBrowse link
G Hspa8 heat shock protein family A (Hsp70) member 8 multiple interactions ISO [Manganese binds to N'-((2-hydroxyphenyl)carbonothioyl)pyridine-2-carbohydrazide] which results in increased expression of HSPA8 protein CTD PMID:16600465 NCBI chr 8:44,989,401...44,993,261
Ensembl chr 8:44,990,014...44,993,179 		JBrowse link
G Htr1a 5-hydroxytryptamine receptor 1A multiple interactions EXP Manganese affects the reaction [Serotonin inhibits the reaction [N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide binds to HTR1A protein]]; Manganese inhibits the reaction [Guanosine Triphosphate affects the reaction [Serotonin binds to HTR1A protein]] CTD PMID:21126535 NCBI chr 2:36,246,628...36,247,896
Ensembl chr 2:36,246,628...36,247,896 		JBrowse link
G Htt huntingtin decreases uptake
multiple interactions
decreases response to substance
decreases abundance		 ISO
EXP		 HTT protein mutant form results in decreased uptake of Manganese
Manganese results in decreased phosphorylation of and results in increased expression of HTT protein
HTT protein mutant form inhibits the reaction [Manganese results in decreased expression of UBQLN1 protein]; HTT protein mutant form inhibits the reaction [Manganese results in increased expression of NEFL protein]; Manganese inhibits the reaction [HTT protein mutant form affects the expression of SAE1 protein]
HTT gene mutant form results in decreased susceptibility to Manganese
HTT gene mutant form results in decreased abundance of Manganese		 CTD PMID:19845833 PMID:20547568 PMID:22191580 PMID:25099302 NCBI chr14:81,105,139...81,254,637
Ensembl chr14:81,105,139...81,254,637 		JBrowse link
G Id2 inhibitor of DNA binding 2 increases expression ISO Manganese results in increased expression of ID2 mRNA CTD PMID:17175027 NCBI chr 6:44,360,077...44,361,908
Ensembl chr 6:44,348,501...44,363,915 		JBrowse link
G Idh3a isocitrate dehydrogenase (NAD(+)) 3 catalytic subunit alpha affects binding ISO Manganese binds to IDH3A protein CTD PMID:16737955 NCBI chr 8:59,164,601...59,183,899
Ensembl chr 8:59,164,572...59,183,908 		JBrowse link
G Idh3g isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit gamma affects binding ISO Manganese binds to IDH3G protein CTD PMID:16737955 NCBI chr  X:156,999,803...157,008,735
Ensembl chr  X:156,999,826...157,008,733 		JBrowse link
G Ifng interferon gamma multiple interactions EXP
ISO		 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [Manganese inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Nitric Oxide]]; 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [Manganese promotes the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Free Radicals]]; 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [Manganese promotes the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 mRNA]]; 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [Manganese promotes the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of TNF mRNA]]; 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [Manganese promotes the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of TNF protein]]; [Lipopolysaccharides co-treated with IFNG protein co-treated with Manganese] results in decreased abundance of Nitric Oxide; [pyrazolanthrone co-treated with Manganese] inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; [SB 203580 co-treated with Manganese] inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; [U 0126 co-treated with Manganese] inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; Manganese inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; Manganese promotes the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Free Radicals]; Manganese promotes the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased degradation of NFKBIA protein]; Manganese promotes the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; Manganese promotes the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 protein]; Manganese promotes the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of TNF mRNA]; Manganese promotes the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of TNF protein]; Manganese promotes the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased phosphorylation of MAPK1 protein]; Manganese promotes the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased phosphorylation of MAPK3 protein]; pyrazolanthrone inhibits the reaction [Manganese promotes the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 mRNA]]; pyrazolanthrone inhibits the reaction [Manganese promotes the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of TNF protein]]; SB 203580 inhibits the reaction [Manganese promotes the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 mRNA]]; SB 203580 inhibits the reaction [Manganese promotes the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of TNF protein]]; U 0126 inhibits the reaction [Manganese promotes the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 mRNA]]; U 0126 inhibits the reaction [Manganese promotes the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of TNF protein]]
Manganese promotes the reaction [[TNF protein co-treated with IFNG protein] promotes the reaction [NOS2 protein results in increased chemical synthesis of Nitric Oxide]]; Manganese promotes the reaction [TNF protein co-treated with and results in increased chemical synthesis of IFNG protein co-treated with and results in increased chemical synthesis of Nitric Oxide]; Manganese promotes the reaction [TNF protein co-treated with and results in increased expression of IFNG protein co-treated with and results in increased expression of NOS2 mRNA]; Manganese promotes the reaction [TNF protein co-treated with and results in increased expression of IFNG protein co-treated with and results in increased expression of NOS2 protein]; NFKBIA protein affects the reaction [Manganese promotes the reaction [TNF protein co-treated with and results in increased chemical synthesis of IFNG protein co-treated with and results in increased chemical synthesis of Nitric Oxide]]; NFKBIA protein affects the reaction [Manganese promotes the reaction [TNF protein co-treated with and results in increased expression of IFNG protein co-treated with and results in increased expression of NOS2 mRNA]]; NFKBIA protein affects the reaction [Manganese promotes the reaction [TNF protein co-treated with and results in increased expression of IFNG protein co-treated with and results in increased expression of NOS2 protein]]		 CTD PMID:16168523 PMID:16488514 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419 		JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta multiple interactions ISO IKBKB gene mutant form results in increased susceptibility to [manganese chloride results in increased abundance of Manganese] CTD PMID:32692843 NCBI chr16:74,177,233...74,230,809
Ensembl chr16:74,177,215...74,230,815 		JBrowse link
G Il12a interleukin 12A increases expression ISO Manganese results in increased expression of IL12A mRNA CTD PMID:17175027 NCBI chr 2:165,076,945...165,083,996
Ensembl chr 2:165,076,607...165,084,318 		JBrowse link
G Il1b interleukin 1 beta increases expression EXP Manganese results in increased expression of IL1B mRNA CTD PMID:19782702 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726 		JBrowse link
G Il1rl1 interleukin 1 receptor-like 1 decreases expression EXP Manganese results in decreased expression of IL1RL1 mRNA CTD PMID:26745496 NCBI chr 9:47,133,483...47,184,316
Ensembl chr 9:47,134,034...47,182,170 		JBrowse link
G Il2 interleukin 2 multiple interactions ISO Manganese promotes the reaction [Tetradecanoylphorbol Acetate results in increased expression of IL2 mRNA]; Manganese promotes the reaction [Tetradecanoylphorbol Acetate results in increased expression of IL2 protein] CTD PMID:22561169 NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854 		JBrowse link
G Il6 interleukin 6 increases expression
increases uptake
multiple interactions
increases secretion		 ISO
EXP		 Manganese results in increased expression of IL6 mRNA; Manganese results in increased expression of IL6 protein
IL6 protein results in increased uptake of Manganese
[IL6 protein results in decreased expression of SLC30A10 mRNA] which results in decreased export of Manganese; [IL6 protein results in decreased expression of SLC30A10 protein] which results in decreased export of Manganese
Manganese results in increased secretion of IL6 protein
[Manganese co-treated with Lipopolysaccharides] results in increased expression of IL6 mRNA		 CTD PMID:17065364 PMID:19263519 PMID:20224926 PMID:20589745 PMID:24576911 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807 		JBrowse link
G Il7 interleukin 7 increases expression ISO Manganese results in increased expression of IL7 mRNA CTD PMID:17175027 NCBI chr 2:96,427,884...96,474,979
Ensembl chr 2:96,439,286...96,474,977 		JBrowse link
G Ins2 insulin 2 multiple interactions ISO [manganese chloride results in increased abundance of Manganese] inhibits the reaction [Glucose results in increased secretion of INS protein]; [Manganese co-treated with Magnesium co-treated with INS protein] results in increased phosphorylation of and results in increased activity of INSR protein; [Polylysine co-treated with Manganese co-treated with Magnesium] promotes the reaction [INS protein results in increased phosphorylation of and results in increased activity of INSR protein modified form]; [Polylysine co-treated with Manganese co-treated with Magnesium] promotes the reaction [INS protein results in increased phosphorylation of and results in increased activity of INSR protein] CTD PMID:2542339 PMID:31555879 NCBI chr 1:215,856,967...215,858,034
Ensembl chr 1:215,856,971...215,858,034 		JBrowse link
G Insr insulin receptor multiple interactions
decreases expression		 EXP
ISO		 [Manganese co-treated with INS1 protein] results in increased phosphorylation of INSR protein
Manganese deficiency results in decreased expression of INSR protein
[Manganese co-treated with Magnesium co-treated with INS protein] results in increased phosphorylation of and results in increased activity of INSR protein; [Polylysine co-treated with Manganese co-treated with Magnesium] promotes the reaction [INS protein results in increased phosphorylation of and results in increased activity of INSR protein modified form]; [Polylysine co-treated with Manganese co-treated with Magnesium] promotes the reaction [INS protein results in increased phosphorylation of and results in increased activity of INSR protein]		 CTD PMID:1321133 PMID:2204694 PMID:2542339 NCBI chr12:1,682,527...1,816,414
Ensembl chr12:1,680,957...1,816,414 		JBrowse link
G Ireb2 iron responsive element binding protein 2 decreases activity
increases expression		 EXP Manganese results in decreased activity of IREB2 protein
Manganese results in increased expression of IREB2 protein		 CTD PMID:16568477 PMID:17469137 NCBI chr 8:59,450,974...59,503,634
Ensembl chr 8:59,420,123...59,501,118 		JBrowse link
G Irs4 insulin receptor substrate 4 multiple interactions EXP [Manganese co-treated with INS1 protein] results in increased phosphorylation of IRS4 protein CTD PMID:1321133 NCBI chr  X:113,003,824...113,018,088 JBrowse link
G Itga3 integrin subunit alpha 3 increases expression ISO Manganese results in increased expression of ITGA3 mRNA CTD PMID:17175027 NCBI chr10:82,855,841...82,887,755
Ensembl chr10:82,855,613...82,887,497 		JBrowse link
G Itgam integrin subunit alpha M increases expression EXP Manganese results in increased expression of ITGAM mRNA CTD PMID:20224926 NCBI chr 1:199,495,312...199,545,738
Ensembl chr 1:199,495,298...199,623,960 		JBrowse link
G Itgb1 integrin subunit beta 1 increases activity EXP Manganese results in increased activity of ITGB1 protein CTD PMID:10820171 PMID:16606368 NCBI chr19:61,677,512...61,725,537
Ensembl chr19:61,677,542...61,725,535 		JBrowse link
G Itgb5 integrin subunit beta 5 increases expression ISO Manganese results in increased expression of ITGB5 mRNA CTD PMID:17175027 NCBI chr11:70,056,500...70,172,164
Ensembl chr11:70,056,500...70,172,372 		JBrowse link
G Itih1 inter-alpha trypsin inhibitor, heavy chain 1 multiple interactions ISO Manganese promotes the reaction [ITIH1 protein binds to TNFAIP6 protein] CTD PMID:16768462 NCBI chr16:7,012,376...7,026,542
Ensembl chr16:7,012,354...7,026,540 		JBrowse link
G Itih2 inter-alpha-trypsin inhibitor heavy chain 2 multiple interactions ISO Manganese promotes the reaction [ITIH2 protein binds to TNFAIP6 protein] CTD PMID:16768462 NCBI chr17:72,160,734...72,197,248
Ensembl chr17:72,160,735...72,195,509 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit decreases expression
multiple interactions		 ISO
EXP		 Manganese results in decreased expression of JUN protein
Manganese promotes the reaction [Tetradecanoylphorbol Acetate results in increased activity of [JUN protein binds to FOS protein]]; Manganese promotes the reaction [Tetradecanoylphorbol Acetate results in increased expression of JUN protein]; Manganese promotes the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of JUN protein]
[Curcumin co-treated with Manganese] inhibits the reaction [Kainic Acid results in increased expression of JUN mRNA]; [diacetylcurcumin co-treated with Manganese] inhibits the reaction [Kainic Acid results in increased expression of JUN mRNA]; NEPP11 compound inhibits the reaction [Manganese results in increased phosphorylation of JUN protein]		 CTD PMID:15342272 PMID:17043766 PMID:17827730 PMID:22561169 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277 		JBrowse link
G Kcnip3 potassium voltage-gated channel interacting protein 3 increases expression ISO Manganese results in increased expression of KCNIP3 mRNA CTD PMID:17175027 NCBI chr 3:120,023,062...120,087,650
Ensembl chr 3:120,023,917...120,087,136 		JBrowse link
G Kcnj11 potassium inwardly-rectifying channel, subfamily J, member 11 multiple interactions ISO KCNJ11 protein affects the reaction [[Manganese co-treated with Dobutamine] results in increased abundance of Calcium]
[manganese chloride results in increased abundance of Manganese] which results in decreased expression of KCNJ11 protein		 CTD PMID:17189350 PMID:32659473 NCBI chr 1:102,103,093...102,107,134
Ensembl chr 1:102,103,094...102,106,127 		JBrowse link
G Kcnj3 potassium inwardly-rectifying channel, subfamily J, member 3 increases expression ISO Manganese results in increased expression of KCNJ3 mRNA CTD PMID:17175027 NCBI chr 3:41,019,898...41,181,070
Ensembl chr 3:41,019,898...41,181,070 		JBrowse link
G Kcnj8 potassium inwardly-rectifying channel, subfamily J, member 8 multiple interactions ISO [manganese chloride results in increased abundance of Manganese] which results in decreased expression of KCNJ8 protein CTD PMID:32659473 NCBI chr 4:176,783,287...176,789,143
Ensembl chr 4:176,782,498...176,789,304 		JBrowse link
G Kera keratocan increases expression EXP Manganese results in increased expression of KERA mRNA CTD PMID:26745496 NCBI chr 7:38,858,062...38,865,515
Ensembl chr 7:38,858,062...38,865,515 		JBrowse link
G Khsrp KH-type splicing regulatory protein multiple interactions
increases expression		 EXP KHSRP protein affects the reaction [Manganese results in increased expression of TP53 protein]
Manganese results in increased expression of KHSRP protein		 CTD PMID:25027559 NCBI chr 9:10,013,795...10,023,670
Ensembl chr 9:10,013,854...10,022,924 		JBrowse link
G Kiss1 KiSS-1 metastasis-suppressor increases expression EXP Manganese results in increased expression of KISS1 mRNA CTD PMID:23997110 NCBI chr13:50,529,506...50,537,603
Ensembl chr13:50,529,510...50,535,389 		JBrowse link
G Kiss1r KISS1 receptor increases expression EXP Manganese results in increased expression of KISS1R mRNA CTD PMID:23997110 NCBI chr 7:12,606,210...12,609,868
Ensembl chr 7:12,606,210...12,609,868 		JBrowse link
G Klf4 Kruppel like factor 4 increases expression ISO Manganese results in increased expression of KLF4 mRNA CTD PMID:17175027 NCBI chr 5:72,283,311...72,287,669
Ensembl chr 5:72,283,313...72,287,669 		JBrowse link
G Klf9 Kruppel-like factor 9 decreases expression ISO Manganese results in decreased expression of KLF9 mRNA CTD PMID:17175027 NCBI chr 1:240,908,483...240,933,198
Ensembl chr 1:240,908,483...240,933,198 		JBrowse link
G Ldhb lactate dehydrogenase B affects expression EXP Manganese affects the expression of LDHB protein CTD PMID:24885898 NCBI chr 4:176,701,980...176,719,999
Ensembl chr 4:176,701,983...176,720,012 		JBrowse link
G Lep leptin decreases abundance ISO LEP gene mutant form results in decreased abundance of Manganese CTD PMID:10965932 NCBI chr 4:56,337,695...56,351,818
Ensembl chr 4:56,337,695...56,351,818 		JBrowse link
G Lman2 lectin, mannose-binding 2 increases expression ISO Manganese results in increased expression of LMAN2 mRNA CTD PMID:17175027 NCBI chr17:9,798,136...9,815,820
Ensembl chr17:9,797,907...9,816,139 		JBrowse link
G LOC100360841 ribosomal protein L37-like decreases expression ISO Manganese results in decreased expression of RPL37 mRNA CTD PMID:27329587 NCBI chr 9:69,790,829...69,791,199
Ensembl chr 9:69,790,831...69,791,196 		JBrowse link
G LOC100911804 apolipoprotein L3-like increases expression ISO Manganese results in increased expression of APOL2 mRNA CTD PMID:17175027 NCBI chr 7:118,979,230...118,986,699
Ensembl chr 7:118,979,608...118,983,984 		JBrowse link
G Lrat lecithin retinol acyltransferase increases expression EXP Manganese results in increased expression of LRAT mRNA CTD PMID:26745496 NCBI chr 2:181,896,304...181,905,366
Ensembl chr 2:181,896,305...181,905,300 		JBrowse link
G Lrrk2 leucine-rich repeat kinase 2 increases response to substance
multiple interactions		 ISO LRRK2 mutant form results in increased susceptibility to Manganese
LRRK2 mutant form results in increased susceptibility to [Manganese co-treated with SLC6A3 protein]		 CTD PMID:23628791 NCBI chr 7:132,857,311...133,018,549
Ensembl chr 7:132,857,628...133,018,584