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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:adinazolam
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Accession:CHEBI:251412 term browser browse the term
Definition:A triazolo[4,3-a][1,4]benzodiazepine having a dimethylaminomethyl group at the 1-position, a phenyl group at the 6-position and a chloro substituent at the 8-position.
Synonyms:exact_synonym: 1-(8-chloro-6-phenyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-1-yl)-N,N-dimethylmethanamine
 related_synonym: 8-Chloro-1-((dimethylamino)methyl)-6-phenyl-4H-s-triazolo(4,3-a)(1,4)benzodiazepine;   Formula=C19H18ClN5;   InChI=1S/C19H18ClN5/c1-24(2)12-18-23-22-17-11-21-19(13-6-4-3-5-7-13)15-10-14(20)8-9-16(15)25(17)18/h3-10H,11-12H2,1-2H3;   InChIKey=GJSLOMWRLALDCT-UHFFFAOYSA-N;   SMILES=CN(C)Cc1nnc2CN=C(c3ccccc3)c3cc(Cl)ccc3-n12;   adinazolamum
 xref: Beilstein:577108;   CAS:37115-32-5;   DrugBank:DB00546;   Drug_Central:93;   KEGG:D02770
 xref_mesh: MESH:C039668
 xref: Patent:DE2201210;   Patent:GB1393256;   Patent:US4250094


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adinazolam term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Crh corticotropin releasing hormone multiple interactions EXP adinazolam inhibits the reaction [CRF protein results in increased secretion of beta-Endorphin] CTD PMID:1480515 NCBI chr 2:104,459,999...104,461,863
Ensembl chr 2:104,459,999...104,461,863
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 decreases methylation
multiple interactions
ISO CYP2C19 protein results in decreased methylation of adinazolam
Omeprazole inhibits the reaction [CYP2C19 protein results in decreased methylation of adinazolam]
CTD PMID:9600717 NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007
JBrowse link
G Htr2a 5-hydroxytryptamine receptor 2A decreases expression EXP adinazolam results in decreased expression of HTR2A protein CTD PMID:1664741 NCBI chr15:56,666,152...56,732,469
Ensembl chr15:56,666,012...56,735,382
JBrowse link
G Trh thyrotropin releasing hormone multiple interactions EXP adinazolam inhibits the reaction [TRH protein modified form binds to TRHR protein] CTD PMID:2845442 NCBI chr 4:124,110,716...124,113,242
Ensembl chr 4:124,110,716...124,113,242
JBrowse link
G Trhr thyrotropin releasing hormone receptor multiple interactions EXP adinazolam inhibits the reaction [TRH protein modified form binds to TRHR protein] CTD PMID:2845442 NCBI chr 7:83,113,641...83,153,520
Ensembl chr 7:83,113,672...83,153,519
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      application 19393
        pharmaceutical 19275
          drug 19275
            central nervous system drug 16431
              psychotropic drug 15052
                antidepressant 3124
                  adinazolam 5
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    p-block element atom 19672
                      carbon group element atom 19574
                        carbon atom 19563
                          organic molecular entity 19563
                            organic molecule 19488
                              organic cyclic compound 19285
                                organic heterocyclic compound 18410
                                  organonitrogen heterocyclic compound 17461
                                    benzodiazepine 542
                                      triazolobenzodiazepine 25
                                        adinazolam 5
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