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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:edrophonium
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Accession:CHEBI:251408 term browser browse the term
Definition:A quaternary ammonium ion that is N-ethyl-N,N-dimethylanilinium in which one of the meta positions is substituted by a hydroxy group. It is a reversible inhibitor of cholinesterase, with a rapid onset (30-60 seconds after injection) but a short duration of action (5-15 minutes). The chloride salt is used in myasthenia gravis both diagnostically and to distinguish between under- or over-treatment with other anticholinesterases. It has also been used for the reversal of neuromuscular blockade in anaesthesia, and for the management of poisoning due to tetrodotoxin, a neuromuscular blocking toxin found in puffer fish and other marine animals.
Synonyms:exact_synonym: N-ethyl-3-hydroxy-N,N-dimethylanilinium
 related_synonym: (3-hydroxyphenyl)dimethylethylammonium;   3-hydroxy-N,N-dimethyl-N-ethylanilinium;   EDROPHONIUM ION;   Ethyl-(3-hydroxy-phenyl)-dimethyl-ammonium;   Formula=C10H16NO;   InChI=1S/C10H15NO/c1-4-11(2,3)9-6-5-7-10(12)8-9/h5-8H,4H2,1-3H3/p+1;   InChIKey=VWLHWLSRQJQWRG-UHFFFAOYSA-O;   N-ethyl-3-hydroxy-N,N-dimethylbenzenaminium;   SMILES=CC[N+](C)(C)c1cccc(O)c1
 alt_id: CHEBI:42376;   CHEBI:4758
 xref: Beilstein:3905622;   CAS:312-48-1;   DrugBank:DB01010;   Drug_Central:988;   KEGG:C06976;   LINCS:LSM-5867
 xref_mesh: MESH:D004491
 xref: PDBeChem:EDR;   PMID:7488499


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  CHEBI ontology 0
    role 0
      application 0
        pharmaceutical 0
          diagnostic agent 0
            edrophonium 0
              edrophonium chloride 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 0
    subatomic particle 0
      composite particle 0
        hadron 0
          baryon 0
            nucleon 0
              atomic nucleus 0
                atom 0
                  main group element atom 0
                    main group molecular entity 0
                      s-block molecular entity 0
                        hydrogen molecular entity 0
                          hydrides 0
                            inorganic hydride 0
                              pnictogen hydride 0
                                nitrogen hydride 0
                                  ammonium 0
                                    ammonium ion derivative 0
                                      quaternary ammonium ion 0
                                        edrophonium 0
                                          edrophonium chloride 0
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