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ONTOLOGY REPORT - ANNOTATIONS


Term:edrophonium
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Accession:CHEBI:251408 term browser browse the term
Definition:A quaternary ammonium ion that is N-ethyl-N,N-dimethylanilinium in which one of the meta positions is substituted by a hydroxy group. It is a reversible inhibitor of cholinesterase, with a rapid onset (30-60 seconds after injection) but a short duration of action (5-15 minutes). The chloride salt is used in myasthenia gravis both diagnostically and to distinguish between under- or over-treatment with other anticholinesterases. It has also been used for the reversal of neuromuscular blockade in anaesthesia, and for the management of poisoning due to tetrodotoxin, a neuromuscular blocking toxin found in puffer fish and other marine animals.
Synonyms:related_synonym: (3-hydroxyphenyl)dimethylethylammonium;   3-hydroxy-N,N-dimethyl-N-ethylanilinium;   EDROPHONIUM ION;   Ethyl-(3-hydroxy-phenyl)-dimethyl-ammonium;   Formula=C10H16NO;   InChI=1S/C10H15NO/c1-4-11(2,3)9-6-5-7-10(12)8-9/h5-8H,4H2,1-3H3/p+1;   InChIKey=VWLHWLSRQJQWRG-UHFFFAOYSA-O;   N-ethyl-3-hydroxy-N,N-dimethylanilinium;   N-ethyl-3-hydroxy-N,N-dimethylbenzenaminium;   SMILES=CC[N+](C)(C)c1cccc(O)c1
 alt_id: CHEBI:42376;   CHEBI:4758
 xref: Beilstein:3905622 "Beilstein";   CAS:312-48-1 "ChemIDplus";   CAS:312-48-1 "KEGG COMPOUND";   DrugBank:DB01010;   Drug_Central:988 "DrugCentral";   KEGG:C06976;   LINCS:LSM-5867
 xref_mesh: MESH:D004491
 xref: PDBeChem:EDR;   PMID:7488499 "Europe PMC"


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edrophonium term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ache acetylcholinesterase JBrowse link 12 22,472,358 22,477,052 RGD:6480464
G Bche butyrylcholinesterase JBrowse link 2 171,104,476 171,196,186 RGD:6480464

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Term Annotations click to browse term
  CHEBI ontology 19669
    role 19613
      application 19235
        pharmaceutical 19097
          diagnostic agent 619
            edrophonium 2
              edrophonium chloride 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19669
    subatomic particle 19665
      composite particle 19665
        hadron 19665
          baryon 19665
            nucleon 19665
              atomic nucleus 19665
                atom 19665
                  main group element atom 19545
                    main group molecular entity 19545
                      s-block molecular entity 19329
                        hydrogen molecular entity 19319
                          hydrides 18242
                            inorganic hydride 17104
                              pnictogen hydride 17062
                                nitrogen hydride 16885
                                  ammonium 8204
                                    ammonium ion derivative 8199
                                      quaternary ammonium ion 5043
                                        edrophonium 2
                                          edrophonium chloride 0
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