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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:magnesium atom
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Accession:CHEBI:25107 term browser browse the term
Definition:An alkaline earth metal atom that has formula Mg.
Synonyms:related_synonym: 12Mg;   Formula=Mg;   InChI=1S/Mg;   InChIKey=FYYHWMGAXLPEAU-UHFFFAOYSA-N;   Magnesium;   Mg;   SMILES=[Mg];   magnesio
 xref: CAS:7439-95-4;   DrugBank:DB01378;   Gmelin:16207;   KEGG:C00305
 xref_mesh: MESH:D008274
 xref: WebElements:Mg


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magnesium atom term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions
increases activity
ISO [Magnesium results in increased activity of ABCB1 protein] which results in increased hydrolysis of Adenosine Triphosphate; Cadmium inhibits the reaction [Magnesium results in increased activity of ABCB1 protein]; Calcium inhibits the reaction [Magnesium results in increased activity of ABCB1 protein]; Copper inhibits the reaction [Magnesium results in increased activity of ABCB1 protein]; Nickel inhibits the reaction [Magnesium results in increased activity of ABCB1 protein]; Zinc inhibits the reaction [Magnesium results in increased activity of ABCB1 protein] CTD PMID:2900677 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcc6 ATP binding cassette subfamily C member 6 multiple interactions ISO [Magnesium deficiency co-treated with Phosphates] promotes the reaction [ABCC6 gene mutant form results in increased susceptibility to Warfarin] CTD PMID:23415960 NCBI chr 1:101,954,786...102,013,252
Ensembl chr 1:101,959,540...102,013,243
JBrowse link
G Adcy5 adenylate cyclase 5 increases activity ISO Magnesium results in increased activity of ADCY5 protein CTD PMID:12065575 NCBI chr11:68,695,839...68,842,452
Ensembl chr11:68,695,839...68,842,320
JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 multiple interactions EXP Magnesium inhibits the reaction [ALDH1A1 protein affects the oxidation of 9-cis-retinal]; Magnesium inhibits the reaction [ALDH1A1 protein affects the oxidation of Retinaldehyde] CTD PMID:17167544 NCBI chr 1:238,222,689...238,264,381
Ensembl chr 1:238,222,521...238,264,330
JBrowse link
G Aldh2 aldehyde dehydrogenase 2 family member multiple interactions
affects activity
EXP
ISO
Magnesium affects the reaction [NAD binds to ALDH2 protein]
Magnesium promotes the reaction [ALDH2 protein results in increased oxidation of propionaldehyde]
Magnesium affects the activity of ALDH2 protein
CTD PMID:21276780, PMID:23295226 NCBI chr12:40,466,418...40,498,813
Ensembl chr12:40,466,495...40,498,752
JBrowse link
G Anxa1 annexin A1 multiple interactions EXP [Magnesium co-treated with Adenosine Triphosphate] affects the activity of ANXA1 protein; arsenite affects the reaction [[Magnesium co-treated with Adenosine Triphosphate] affects the activity of ANXA1 protein]; Cadmium affects the reaction [[Magnesium co-treated with Adenosine Triphosphate] affects the activity of ANXA1 protein]; chromium hexavalent ion affects the reaction [[Magnesium co-treated with Adenosine Triphosphate] affects the activity of ANXA1 protein]; Lead affects the reaction [[Magnesium co-treated with Adenosine Triphosphate] affects the activity of ANXA1 protein] CTD PMID:20655937 NCBI chr 1:237,893,983...237,910,002
Ensembl chr 1:237,893,966...237,910,012
JBrowse link
G Atp7b ATPase copper transporting beta increases phosphorylation ISO Magnesium results in increased phosphorylation of ATP7B protein CTD PMID:19405516 NCBI chr16:74,865,516...74,944,935
Ensembl chr16:74,865,516...74,945,286
JBrowse link
G Bglap bone gamma-carboxyglutamate protein increases expression ISO Magnesium results in increased expression of BGLAP protein CTD PMID:10397942 NCBI chr 2:187,741,770...187,748,445
Ensembl chr 2:187,741,770...187,742,747
JBrowse link
G C3 complement C3 multiple interactions ISO [cobra venom factor co-treated with Magnesium] results in increased cleavage of and results in increased activity of C3 protein; CFD protein affects the reaction [[cobra venom factor co-treated with Magnesium] results in increased cleavage of and results in increased activity of C3 protein] CTD PMID:11724962 NCBI chr 9:9,721,137...9,747,084
Ensembl chr 9:9,721,105...9,747,167
JBrowse link
G Calca calcitonin-related polypeptide alpha decreases abundance
affects metabolic processing
ISO CALCA gene mutant form results in decreased abundance of Magnesium
CALCA protein affects the metabolism of Magnesium
CTD PMID:15039145 NCBI chr 1:184,184,018...184,188,922
Ensembl chr 1:184,184,020...184,188,911
JBrowse link
G Casr calcium-sensing receptor increases expression
multiple interactions
increases response to substance
EXP
ISO
Magnesium results in increased expression of CASR mRNA; Magnesium results in increased expression of CASR protein
[Magnesium binds to and results in increased activity of CASR protein] which results in increased abundance of Calcium; [Magnesium binds to and results in increased activity of CASR protein] which results in increased abundance of Inositol Phosphates; Magnesium binds to and results in increased activity of CASR protein
CASR protein results in increased susceptibility to Magnesium
CTD PMID:10231437, PMID:11563847, PMID:15068510 NCBI chr11:67,188,204...67,262,261
Ensembl chr11:67,188,630...67,258,771
JBrowse link
G Cerk ceramide kinase multiple interactions ISO Magnesium affects the reaction [CERK protein results in increased phosphorylation of Ceramides] CTD PMID:16269826 NCBI chr 7:127,015,162...127,058,056
Ensembl chr 7:127,015,162...127,058,056
JBrowse link
G Cfb complement factor B multiple interactions ISO CFD protein affects the reaction [[cobra venom factor co-treated with Magnesium co-treated with Calcium] results in increased cleavage of CFB protein] CTD PMID:11724962 NCBI chr20:4,536,206...4,542,073
Ensembl chr20:4,536,203...4,561,066
Ensembl chr20:4,536,203...4,561,066
JBrowse link
G Cfd complement factor D multiple interactions ISO CFD protein affects the reaction [[cobra venom factor co-treated with Magnesium co-treated with Calcium] results in increased cleavage of CFB protein]; CFD protein affects the reaction [[cobra venom factor co-treated with Magnesium] results in increased cleavage of and results in increased activity of C3 protein] CTD PMID:11724962 NCBI chr 7:12,634,216...12,635,939
Ensembl chr 7:12,634,216...12,635,943
JBrowse link
G Cln6 CLN6, transmembrane ER protein increases abundance ISO CLN6 gene mutant form results in increased abundance of Magnesium CTD PMID:23789114 NCBI chr 8:67,733,215...67,748,170
Ensembl chr 8:67,733,215...67,748,172
JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions ISO [Aluminum Oxide co-treated with Magnesium] results in increased expression of COL1A1 protein CTD PMID:12209937 NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789
JBrowse link
G Col1a2 collagen type I alpha 2 chain increases expression
affects abundance
ISO Magnesium results in increased expression of COL1A2 protein
COL1A2 protein affects the abundance of Magnesium
CTD PMID:10397942, PMID:10913914 NCBI chr 4:31,534,225...31,569,152
Ensembl chr 4:31,534,225...31,569,151
JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 multiple interactions EXP [Magnesium co-treated with Selenium co-treated with Dietary Fats] results in increased expression of CYP7A1 mRNA CTD PMID:30031400 NCBI chr 5:19,358,734...19,368,431
Ensembl chr 5:19,358,734...19,368,431
JBrowse link
G Dnmt1 DNA methyltransferase 1 decreases activity
multiple interactions
ISO Magnesium results in decreased activity of DNMT1 protein
Magnesium promotes the reaction [epigallocatechin gallate results in decreased activity of DNMT1 protein]
CTD PMID:16037419 NCBI chr 8:21,922,515...21,968,495
Ensembl chr 8:21,922,515...21,968,495
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions EXP [[gluconic acid results in increased abundance of Magnesium] co-treated with [Sodium Selenite results in increased abundance of Selenium]] inhibits the reaction [Dietary Fats results in increased expression of GPT protein] CTD PMID:30031400 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931
JBrowse link
G Grin2b glutamate ionotropic receptor NMDA type subunit 2B multiple interactions EXP Magnesium inhibits the reaction [ifenprodil binds to and results in decreased activity of GRIN2B protein] CTD PMID:9729614 NCBI chr 4:169,541,620...170,000,216
Ensembl chr 4:169,560,387...169,999,873
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions ISO Magnesium affects the reaction [Lithium results in decreased activity of GSK3B protein] CTD PMID:10998351 NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268
JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase multiple interactions EXP [[gluconic acid results in increased abundance of Magnesium] co-treated with [Sodium Selenite results in increased abundance of Selenium]] inhibits the reaction [Dietary Fats results in increased expression of HMGCR mRNA] CTD PMID:30031400 NCBI chr 2:27,480,224...27,500,654
Ensembl chr 2:27,480,226...27,500,654
JBrowse link
G Htr1a 5-hydroxytryptamine receptor 1A multiple interactions EXP Magnesium affects the reaction [Serotonin inhibits the reaction [N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide binds to HTR1A protein]] CTD PMID:21126535 NCBI chr 2:36,246,628...36,247,896
Ensembl chr 2:36,246,628...36,247,896
JBrowse link
G Ibsp integrin-binding sialoprotein increases expression ISO Magnesium results in increased expression of IBSP protein CTD PMID:10397942 NCBI chr14:6,801,200...6,813,987
Ensembl chr14:6,801,204...6,813,945
JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP Magnesium deficiency promotes the reaction [Lipopolysaccharides results in increased expression of IL1B protein] CTD PMID:13679239 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Ins2 insulin 2 multiple interactions ISO [Magnesium co-treated with INS protein] results in increased phosphorylation of and results in increased activity of INSR protein; [Manganese co-treated with Magnesium co-treated with INS protein] results in increased phosphorylation of and results in increased activity of INSR protein; [Polylysine co-treated with Manganese co-treated with Magnesium] promotes the reaction [INS protein results in increased phosphorylation of and results in increased activity of INSR protein modified form]; [Polylysine co-treated with Manganese co-treated with Magnesium] promotes the reaction [INS protein results in increased phosphorylation of and results in increased activity of INSR protein] CTD PMID:2542339 NCBI chr 1:215,856,967...215,858,034
Ensembl chr 1:215,856,971...215,858,034
JBrowse link
G Insr insulin receptor multiple interactions ISO [Magnesium co-treated with INS protein] results in increased phosphorylation of and results in increased activity of INSR protein; [Manganese co-treated with Magnesium co-treated with INS protein] results in increased phosphorylation of and results in increased activity of INSR protein; [Polylysine co-treated with Manganese co-treated with Magnesium] promotes the reaction [INS protein results in increased phosphorylation of and results in increased activity of INSR protein modified form]; [Polylysine co-treated with Manganese co-treated with Magnesium] promotes the reaction [INS protein results in increased phosphorylation of and results in increased activity of INSR protein] CTD PMID:2542339 NCBI chr12:1,682,527...1,816,414
Ensembl chr12:1,680,957...1,816,414
JBrowse link
G Itga5 integrin subunit alpha 5 multiple interactions ISO [Aluminum Oxide co-treated with Magnesium] results in increased expression of ITGA5 protein CTD PMID:12209937 NCBI chr 7:144,970,444...144,993,652
Ensembl chr 7:144,970,444...144,993,652
JBrowse link
G Itgb1 integrin subunit beta 1 multiple interactions ISO [Aluminum Oxide co-treated with Magnesium] results in increased expression of ITGB1 protein CTD PMID:12209937 NCBI chr19:61,677,512...61,725,537
Ensembl chr19:61,677,542...61,725,535
JBrowse link
G Itih1 inter-alpha trypsin inhibitor, heavy chain 1 multiple interactions ISO Magnesium promotes the reaction [ITIH1 protein binds to TNFAIP6 protein] CTD PMID:16768462 NCBI chr16:7,012,376...7,026,542
Ensembl chr16:7,012,354...7,026,540
JBrowse link
G Itih2 inter-alpha-trypsin inhibitor heavy chain 2 multiple interactions ISO Magnesium promotes the reaction [ITIH2 protein binds to TNFAIP6 protein] CTD PMID:16768462 NCBI chr17:72,160,734...72,197,248
Ensembl chr17:72,160,735...72,195,509
JBrowse link
G Klk1 kallikrein 1 decreases activity ISO Magnesium results in decreased activity of KLK1 protein CTD PMID:15558947 NCBI chr 1:100,131,562...100,135,556
Ensembl chr 1:100,059,967...100,203,329
Ensembl chr 1:100,059,967...100,203,329
Ensembl chr 1:100,059,967...100,203,329
JBrowse link
G Klk8 kallikrein related-peptidase 8 increases activity ISO Magnesium results in increased activity of KLK8 protein CTD PMID:16800733 NCBI chr 1:99,735,168...99,742,011
Ensembl chr 1:99,734,993...99,742,009
JBrowse link
G Lcat lecithin cholesterol acyltransferase multiple interactions EXP [[gluconic acid results in increased abundance of Magnesium] co-treated with [Sodium Selenite results in increased abundance of Selenium]] inhibits the reaction [Dietary Fats results in decreased expression of LCAT mRNA] CTD PMID:30031400 NCBI chr19:37,913,333...37,916,799
Ensembl chr19:37,913,336...37,916,813
JBrowse link
G Marco macrophage receptor with collagenous structure multiple interactions ISO Magnesium promotes the reaction [titanium dioxide binds to MARCO protein] CTD PMID:18836211 NCBI chr16:85,115,199...85,147,683
Ensembl chr16:85,115,201...85,135,859
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP Magnesium deficiency promotes the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA] CTD PMID:15466955 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nr1h3 nuclear receptor subfamily 1, group H, member 3 multiple interactions EXP [[gluconic acid results in increased abundance of Magnesium] co-treated with [Sodium Selenite results in increased abundance of Selenium]] affects the reaction [Dietary Fats results in increased expression of NR1H3 mRNA] CTD PMID:30031400 NCBI chr 3:80,004,130...80,014,197
Ensembl chr 3:80,004,130...80,012,750
JBrowse link
G Nt5c3a 5'-nucleotidase, cytosolic IIIA affects binding ISO Magnesium binds to NT5C3 protein CTD PMID:16672222 NCBI chr 4:87,238,325...87,281,234
Ensembl chr 4:87,237,949...87,281,157
JBrowse link
G Nudt9 nudix hydrolase 9 multiple interactions
increases activity
ISO Dithiothreitol inhibits the reaction [Hydrogen Peroxide inhibits the reaction [Magnesium results in increased activity of NUDT9 protein]]; Fluorides inhibits the reaction [Magnesium results in increased activity of NUDT9 protein]; Hydrogen Peroxide inhibits the reaction [Magnesium results in increased activity of NUDT9 protein] CTD PMID:16860484 NCBI chr14:7,036,809...7,054,739
Ensembl chr14:7,036,820...7,054,548
JBrowse link
G Oprd1 opioid receptor, delta 1 multiple interactions EXP Magnesium promotes the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to OPRD1 protein]; Zinc inhibits the reaction [Magnesium promotes the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to OPRD1 protein]] CTD PMID:2162496 NCBI chr 5:150,288,126...150,323,063
Ensembl chr 5:150,288,126...150,323,063
JBrowse link
G Oprk1 opioid receptor, kappa 1 multiple interactions EXP Magnesium promotes the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to OPRK1 protein] CTD PMID:2162496 NCBI chr 5:13,742,655...13,760,460
Ensembl chr 5:13,744,658...13,760,305
JBrowse link
G Oprm1 opioid receptor, mu 1 multiple interactions EXP Magnesium promotes the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to OPRM1 protein]; Zinc inhibits the reaction [Magnesium promotes the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to OPRM1 protein]] CTD PMID:2162496 NCBI chr 1:43,454,803...43,704,948
Ensembl chr 1:43,454,803...43,704,948
JBrowse link
G Pomc proopiomelanocortin multiple interactions
increases uptake
decreases uptake
EXP Phentolamine inhibits the reaction [POMC results in increased uptake of Magnesium]
POMC modified form results in decreased uptake of Magnesium
CTD PMID:191614 NCBI chr 6:28,382,937...28,388,771
Ensembl chr 6:28,382,962...28,388,967
JBrowse link
G Prkcd protein kinase C, delta affects localization ISO Magnesium affects the localization of PRKCD protein CTD PMID:8106444 NCBI chr16:6,655,131...6,675,746
Ensembl chr16:6,655,120...6,675,746
JBrowse link
G Prl prolactin multiple interactions ISO Magnesium promotes the reaction [PRL protein binds to PRLR protein] CTD PMID:6197504 NCBI chr17:39,814,236...39,824,299
Ensembl chr17:39,814,244...39,824,299
JBrowse link
G Prlr prolactin receptor multiple interactions ISO Magnesium promotes the reaction [PRL protein binds to PRLR protein] CTD PMID:6197504 NCBI chr 2:60,131,410...60,325,686
Ensembl chr 2:60,131,776...60,325,692
JBrowse link
G Ptk2 protein tyrosine kinase 2 multiple interactions ISO [Aluminum Oxide co-treated with Magnesium] results in increased expression of PTK2 protein CTD PMID:12209937 NCBI chr 7:114,436,419...114,611,317
Ensembl chr 7:114,437,361...114,590,119
JBrowse link
G Serpine1 serpin family E member 1 increases stability ISO Magnesium results in increased stability of SERPINE1 protein CTD PMID:21280127, PMID:21280128 NCBI chr12:22,641,104...22,651,482
Ensembl chr12:22,641,104...22,651,482
JBrowse link
G Shc1 SHC adaptor protein 1 multiple interactions ISO [Aluminum Oxide co-treated with Magnesium] results in increased expression of SHC1 protein; [Aluminum Oxide co-treated with Magnesium] results in increased expression of SHC1 protein alternative form CTD PMID:12209937 NCBI chr 2:188,745,503...188,757,066
Ensembl chr 2:188,745,503...188,757,066
JBrowse link
G Slc12a4 solute carrier family 12 member 4 affects expression
multiple interactions
ISO Magnesium affects the expression of SLC12A4 mRNA
Magnesium affects the reaction [SLC12A4 protein results in increased transport of Potassium]
CTD PMID:11703599 NCBI chr19:37,917,003...37,938,952
Ensembl chr19:37,917,014...37,938,857
JBrowse link
G Sparc secreted protein acidic and cysteine rich increases expression ISO Magnesium results in increased expression of SPARC protein CTD PMID:10397942 NCBI chr10:40,742,390...40,764,232
Ensembl chr10:40,742,400...40,764,185
JBrowse link
G Spp1 secreted phosphoprotein 1 increases expression ISO Magnesium results in increased expression of SPP1 protein CTD PMID:10397942 NCBI chr14:6,673,686...6,679,965
Ensembl chr14:6,673,686...6,679,901
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions EXP [[gluconic acid results in increased abundance of Magnesium] co-treated with [Sodium Selenite results in increased abundance of Selenium]] inhibits the reaction [Dietary Fats results in increased expression of SREBF1 mRNA] CTD PMID:30031400 NCBI chr10:46,570,996...46,593,021
Ensembl chr10:46,570,996...46,593,009
JBrowse link
G Thbs1 thrombospondin 1 increases expression ISO Magnesium results in increased expression of THBS1 protein CTD PMID:10397942 NCBI chr 3:109,862,120...109,873,466
Ensembl chr 3:109,862,117...109,873,466
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP Magnesium deficiency promotes the reaction [Lipopolysaccharides results in increased expression of TNF protein] CTD PMID:13679239 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tnfaip6 TNF alpha induced protein 6 multiple interactions ISO Magnesium promotes the reaction [ITIH1 protein binds to TNFAIP6 protein]; Magnesium promotes the reaction [ITIH2 protein binds to TNFAIP6 protein] CTD PMID:16768462 NCBI chr 3:37,545,238...37,564,704
Ensembl chr 3:37,545,238...37,564,699
JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A multiple interactions EXP Magnesium deficiency promotes the reaction [Lipopolysaccharides results in increased expression of TNFRSF1A mRNA] CTD PMID:13679239 NCBI chr 4:157,864,905...157,877,634
Ensembl chr 4:157,864,969...157,877,633
JBrowse link
G Trpm7 transient receptor potential cation channel, subfamily M, member 7 multiple interactions
decreases abundance
increases transport
decreases activity
affects transport
affects abundance
ISO
EXP
Magnesium inhibits the reaction [TRPM7 protein results in increased abundance of Calcium]; TRPM7 gene polymorphism affects the susceptibility to [Magnesium co-treated with Calcium, Dietary]
TRPM7 gene mutant form results in decreased abundance of Magnesium
TRPM7 protein results in increased transport of Magnesium
Magnesium results in decreased activity of TRPM7 protein
Magnesium deficiency promotes the reaction [TRPM7 protein results in increased import of Cadmium]; Magnesium inhibits the reaction [TRPM7 protein results in increased import of Cadmium]
Oxygen deficiency promotes the reaction [TRPM7 protein affects the transport of Magnesium]
TRPM7 protein affects the abundance of Magnesium
CTD PMID:17823441, PMID:19515901, PMID:20932883, PMID:21487014, PMID:30770447 NCBI chr 3:119,258,189...119,347,084
Ensembl chr 3:119,259,467...119,330,345
JBrowse link
G Urod uroporphyrinogen decarboxylase affects abundance ISO UROD protein affects the abundance of Magnesium CTD PMID:16325539 NCBI chr 5:135,855,429...135,859,515
Ensembl chr 5:135,855,433...135,859,643
JBrowse link
magnesium dichloride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc6 ATP binding cassette subfamily C member 6 multiple interactions EXP Magnesium Chloride promotes the reaction [8-azidoadenosine 5'-triphosphate binds to ABCC6 protein]; Magnesium Chloride promotes the reaction [beryllium fluoride promotes the reaction [8-azidoadenosine 5'-triphosphate binds to ABCC6 protein]] CTD PMID:12069597 NCBI chr 1:101,954,786...102,013,252
Ensembl chr 1:101,959,540...102,013,243
JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 multiple interactions
decreases activity
EXP Magnesium Chloride inhibits the reaction [ALDH1A1 protein affects the oxidation of 9-cis-retinal]; Magnesium Chloride inhibits the reaction [ALDH1A1 protein affects the oxidation of Retinaldehyde]
Magnesium Chloride results in decreased activity of ALDH1A1 protein
CTD PMID:10998257, PMID:17167544 NCBI chr 1:238,222,689...238,264,381
Ensembl chr 1:238,222,521...238,264,330
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO
EXP
Magnesium Chloride results in increased expression of BAX protein CTD PMID:17977900 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Casp3 caspase 3 increases activity ISO
EXP
Magnesium Chloride results in increased activity of CASP3 protein CTD PMID:17977900 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Cd28 Cd28 molecule multiple interactions ISO Magnesium Chloride promotes the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of CD28 protein] CTD PMID:8662792 NCBI chr 9:67,546,408...67,573,858
Ensembl chr 9:67,546,408...67,571,871
JBrowse link
G Egf epidermal growth factor multiple interactions ISO [Magnesium Chloride co-treated with EGF protein] results in increased activity of EGFR protein CTD PMID:2354210 NCBI chr 2:68,820,616...68,895,537 JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO [Magnesium Chloride co-treated with EGF protein] results in increased activity of EGFR protein CTD PMID:2354210 NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions EXP [2-tert-butylhydroquinone promotes the reaction [[NFE2L2 protein binds to HMOX1 promoter] which results in increased expression of HMOX1 mRNA]] which results in decreased susceptibility to Magnesium Chloride CTD PMID:21107535 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Itih1 inter-alpha trypsin inhibitor, heavy chain 1 multiple interactions ISO Magnesium Chloride promotes the reaction [ITIH1 protein binds to TNFAIP6 protein] CTD PMID:16768462 NCBI chr16:7,012,376...7,026,542
Ensembl chr16:7,012,354...7,026,540
JBrowse link
G Itih2 inter-alpha-trypsin inhibitor heavy chain 2 multiple interactions ISO Magnesium Chloride promotes the reaction [ITIH2 protein binds to TNFAIP6 protein] CTD PMID:16768462 NCBI chr17:72,160,734...72,197,248
Ensembl chr17:72,160,735...72,195,509
JBrowse link
G Kif5a kinesin family member 5A multiple interactions ISO Magnesium Chloride affects the reaction [zinc chloride results in decreased activity of KIF5A protein] CTD PMID:28122263 NCBI chr 7:70,515,832...70,552,897
Ensembl chr 7:70,513,343...70,556,827
JBrowse link
G Klk8 kallikrein related-peptidase 8 increases activity ISO Magnesium Chloride results in increased activity of KLK8 protein CTD PMID:16800733 NCBI chr 1:99,735,168...99,742,011
Ensembl chr 1:99,734,993...99,742,009
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions EXP [2-tert-butylhydroquinone promotes the reaction [[NFE2L2 protein binds to HMOX1 promoter] which results in increased expression of HMOX1 mRNA]] which results in decreased susceptibility to Magnesium Chloride CTD PMID:21107535 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nudt9 nudix hydrolase 9 multiple interactions
increases activity
ISO Dithiothreitol inhibits the reaction [Hydrogen Peroxide inhibits the reaction [Magnesium Chloride results in increased activity of NUDT9 protein]]; Fluorides inhibits the reaction [Magnesium Chloride results in increased activity of NUDT9 protein]; Hydrogen Peroxide inhibits the reaction [Magnesium Chloride results in increased activity of NUDT9 protein] CTD PMID:16860484 NCBI chr14:7,036,809...7,054,739
Ensembl chr14:7,036,820...7,054,548
JBrowse link
G Serpine1 serpin family E member 1 multiple interactions ISO Magnesium Chloride affects the reaction [Nickel binds to SERPINE1 protein] CTD PMID:21280128 NCBI chr12:22,641,104...22,651,482
Ensembl chr12:22,641,104...22,651,482
JBrowse link
G Smpd3 sphingomyelin phosphodiesterase 3 multiple interactions ISO [Magnesium Chloride co-treated with Phosphatidylserines] promotes the reaction [SMPD3 protein results in increased degradation of Sphingomyelins] CTD PMID:12566438 NCBI chr19:38,237,963...38,321,572
Ensembl chr19:38,237,965...38,321,528
JBrowse link
G Tnfaip6 TNF alpha induced protein 6 multiple interactions ISO Magnesium Chloride promotes the reaction [ITIH1 protein binds to TNFAIP6 protein]; Magnesium Chloride promotes the reaction [ITIH2 protein binds to TNFAIP6 protein] CTD PMID:16768462 NCBI chr 3:37,545,238...37,564,704
Ensembl chr 3:37,545,238...37,564,699
JBrowse link
G Tp53 tumor protein p53 affects expression EXP Magnesium Chloride affects the expression of TP53 mRNA CTD PMID:10506531 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
magnesium dihydroxide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp1 caspase 1 multiple interactions ISO [Aluminum Hydroxide co-treated with Magnesium Hydroxide] promotes the reaction [N-t-butyl-n'-tetradecyl-3-tetradecylaminopropionamidine results in increased activity of CASP1 protein]; [Aluminum Hydroxide co-treated with Magnesium Hydroxide] promotes the reaction [N-t-butyl-n'-tetradecyl-3-tetradecylaminopropionamidine results in increased expression of and results in increased secretion of CASP1 protein modified form]; CASP1 protein affects the reaction [[Lipopolysaccharides co-treated with [Aluminum Hydroxide co-treated with Magnesium Hydroxide]] results in increased cleavage of and results in increased secretion of IL1B protein] CTD PMID:18604214, PMID:22075093 NCBI chr 8:2,605,743...2,614,637
Ensembl chr 8:2,604,962...2,614,631
JBrowse link
G Chrna4 cholinergic receptor nicotinic alpha 4 subunit multiple interactions ISO Magnesium Hydroxide inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein co-treated with CHRNB2 protein]] CTD PMID:22750351 NCBI chr 3:176,533,182...176,547,965
Ensembl chr 3:176,527,516...176,548,208
JBrowse link
G Chrnb2 cholinergic receptor nicotinic beta 2 subunit multiple interactions ISO Magnesium Hydroxide inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein co-treated with CHRNB2 protein]] CTD PMID:22750351 NCBI chr 2:189,088,570...189,096,785
Ensembl chr 2:189,088,570...189,096,785
JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 multiple interactions ISO [Aluminum Hydroxide co-treated with Magnesium Hydroxide] inhibits the reaction [K-12 lipopolysaccharide results in increased secretion of CXCL10 protein] CTD PMID:17404311 NCBI chr14:17,210,733...17,212,930
Ensembl chr14:17,210,733...17,212,930
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO [[Aluminum Hydroxide co-treated with Magnesium Hydroxide] co-treated with K-12 lipopolysaccharide] results in increased secretion of IL1B protein modified form; [Aluminum Hydroxide co-treated with Magnesium Hydroxide] results in increased secretion of IL1B protein; [Lipopolysaccharides co-treated with [Aluminum Hydroxide co-treated with Magnesium Hydroxide]] results in increased cleavage of and results in increased secretion of IL1B protein; CASP1 protein affects the reaction [[Lipopolysaccharides co-treated with [Aluminum Hydroxide co-treated with Magnesium Hydroxide]] results in increased cleavage of and results in increased secretion of IL1B protein]; N-t-butyl-n'-tetradecyl-3-tetradecylaminopropionamidine promotes the reaction [[Aluminum Hydroxide co-treated with Magnesium Hydroxide] results in increased secretion of IL1B protein]
[[Aluminum Hydroxide co-treated with Magnesium Hydroxide] co-treated with N-t-butyl-n'-tetradecyl-3-tetradecylaminopropionamidine] results in increased secretion of IL1B protein; [Lipopolysaccharides co-treated with [Aluminum Hydroxide co-treated with Magnesium Hydroxide]] results in increased cleavage of and results in increased secretion of IL1B protein; IL1R1 protein affects the reaction [[Lipopolysaccharides co-treated with [Aluminum Hydroxide co-treated with Magnesium Hydroxide]] results in increased cleavage of and results in increased secretion of IL1B protein]; NLRP3 protein affects the reaction [[Lipopolysaccharides co-treated with [Aluminum Hydroxide co-treated with Magnesium Hydroxide]] results in increased cleavage of and results in increased secretion of IL1B protein]; PYCARD protein affects the reaction [[Lipopolysaccharides co-treated with [Aluminum Hydroxide co-treated with Magnesium Hydroxide]] results in increased cleavage of and results in increased secretion of IL1B protein]
CTD PMID:17404311, PMID:18604214, PMID:22075093 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il1r1 interleukin 1 receptor type 1 multiple interactions ISO IL1R1 protein affects the reaction [[Lipopolysaccharides co-treated with [Aluminum Hydroxide co-treated with Magnesium Hydroxide]] results in increased cleavage of and results in increased secretion of IL1B protein] CTD PMID:18604214 NCBI chr 9:46,962,291...47,038,139
Ensembl chr 9:46,962,288...47,036,670
JBrowse link
G Il2 interleukin 2 multiple interactions ISO [Aluminum Hydroxide co-treated with Magnesium Hydroxide] results in increased secretion of IL2 protein; N-t-butyl-n'-tetradecyl-3-tetradecylaminopropionamidine promotes the reaction [[Aluminum Hydroxide co-treated with Magnesium Hydroxide] results in increased secretion of IL2 protein]; TLR4 protein affects the reaction [N-t-butyl-n'-tetradecyl-3-tetradecylaminopropionamidine promotes the reaction [[Aluminum Hydroxide co-treated with Magnesium Hydroxide] results in increased secretion of IL2 protein]] CTD PMID:22075093 NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854
JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions ISO NLRP3 protein affects the reaction [[Lipopolysaccharides co-treated with [Aluminum Hydroxide co-treated with Magnesium Hydroxide]] results in increased cleavage of and results in increased secretion of IL1B protein] CTD PMID:18604214 NCBI chr10:45,884,324...45,918,290
Ensembl chr10:45,893,018...45,918,254
JBrowse link
G Pycard PYD and CARD domain containing multiple interactions ISO PYCARD protein affects the reaction [[Lipopolysaccharides co-treated with [Aluminum Hydroxide co-treated with Magnesium Hydroxide]] results in increased cleavage of and results in increased secretion of IL1B protein] CTD PMID:18604214 NCBI chr 1:199,438,029...199,439,062
Ensembl chr 1:199,437,832...199,439,210
JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions ISO TLR4 protein affects the reaction [N-t-butyl-n'-tetradecyl-3-tetradecylaminopropionamidine promotes the reaction [[Aluminum Hydroxide co-treated with Magnesium Hydroxide] results in increased secretion of IL2 protein]]; TLR4 protein affects the susceptibility to [[Aluminum Hydroxide co-treated with Magnesium Hydroxide] co-treated with N-t-butyl-n'-tetradecyl-3-tetradecylaminopropionamidine]; TLR4 protein affects the susceptibility to [Aluminum Hydroxide co-treated with Magnesium Hydroxide] CTD PMID:22075093 NCBI chr 5:82,587,424...82,601,056
Ensembl chr 5:82,587,420...82,601,052
JBrowse link
magnesium ion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hmbs hydroxymethylbilane synthase decreases activity EXP Magnesium ion decreases activity of purified Hmbs protein RGD PMID:6732900 RGD:25394584 NCBI chr 8:48,667,278...48,674,673
Ensembl chr 8:48,667,275...48,674,748
JBrowse link
magnesium oxide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO [Selenium analog co-treated with Magnesium Oxide analog] inhibits the reaction [Diazinon results in increased expression of BAX mRNA]; Magnesium Oxide analog inhibits the reaction [Diazinon results in increased expression of BAX mRNA] CTD PMID:27920530 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO [Selenium analog co-treated with Magnesium Oxide analog] inhibits the reaction [Diazinon results in decreased expression of BCL2 mRNA]; Magnesium Oxide analog inhibits the reaction [Diazinon results in decreased expression of BCL2 mRNA] CTD PMID:27920530 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 multiple interactions ISO [Selenium analog co-treated with Magnesium Oxide analog] inhibits the reaction [Diazinon results in decreased expression of BIRC5 mRNA]; Magnesium Oxide analog inhibits the reaction [Diazinon results in decreased expression of BIRC5 mRNA] CTD PMID:27920530 NCBI chr10:106,856,097...106,864,419
Ensembl chr10:106,856,097...106,864,413
JBrowse link
G Casp3 caspase 3 multiple interactions ISO [Selenium analog co-treated with Magnesium Oxide analog] inhibits the reaction [Diazinon results in increased expression of CASP3 mRNA]; Magnesium Oxide analog inhibits the reaction [Diazinon results in increased activity of CASP3 protein]; Magnesium Oxide analog inhibits the reaction [Diazinon results in increased expression of CASP3 mRNA] CTD PMID:27920530 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp8 caspase 8 multiple interactions ISO Magnesium Oxide analog inhibits the reaction [Diazinon results in increased expression of CASP8 mRNA] CTD PMID:27920530 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Casp9 caspase 9 multiple interactions ISO Magnesium Oxide analog inhibits the reaction [Diazinon results in increased activity of CASP9 protein]; Magnesium Oxide analog inhibits the reaction [Diazinon results in increased expression of CASP9 mRNA]; Selenium analog inhibits the reaction [Magnesium Oxide analog inhibits the reaction [Diazinon results in increased expression of CASP9 mRNA]] CTD PMID:27920530 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cat catalase decreases expression EXP Magnesium Oxide results in decreased expression of CAT protein CTD PMID:29282847 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Cflar CASP8 and FADD-like apoptosis regulator multiple interactions ISO [Selenium analog co-treated with Magnesium Oxide analog] inhibits the reaction [Diazinon results in increased expression of CFLAR mRNA]; Magnesium Oxide analog inhibits the reaction [Diazinon results in increased expression of CFLAR mRNA] CTD PMID:27920530 NCBI chr 9:65,534,608...65,586,395
Ensembl chr 9:65,534,704...65,587,251
JBrowse link
G Cycs cytochrome c, somatic multiple interactions ISO [Selenium analog co-treated with Magnesium Oxide analog] inhibits the reaction [Diazinon results in increased expression of CYCS mRNA]; Magnesium Oxide analog inhibits the reaction [Diazinon results in increased expression of CYCS mRNA] CTD PMID:27920530 NCBI chr 4:80,331,226...80,333,326
Ensembl chr 4:80,331,227...80,333,326
JBrowse link
G Fadd Fas associated via death domain multiple interactions ISO [Selenium analog co-treated with Magnesium Oxide analog] promotes the reaction [Diazinon results in decreased expression of FADD mRNA]; Magnesium Oxide promotes the reaction [Diazinon results in decreased expression of FADD mRNA] CTD PMID:27920530 NCBI chr 1:217,746,176...217,748,581
Ensembl chr 1:217,742,929...217,748,628
JBrowse link
G Fas Fas cell surface death receptor multiple interactions ISO [Selenium analog co-treated with Magnesium Oxide analog] inhibits the reaction [Diazinon results in increased expression of FAS mRNA]; Magnesium Oxide analog inhibits the reaction [Diazinon results in increased expression of FAS mRNA] CTD PMID:27920530 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790
JBrowse link
G Faslg Fas ligand multiple interactions ISO [Selenium analog co-treated with Magnesium Oxide analog] promotes the reaction [Diazinon results in decreased expression of FASLG mRNA] CTD PMID:27920530 NCBI chr13:79,696,811...79,717,581
Ensembl chr13:79,698,445...79,705,705
JBrowse link
G Ins2 insulin 2 multiple interactions ISO [Selenium analog co-treated with Magnesium Oxide analog] inhibits the reaction [Diazinon results in decreased secretion of INS protein alternative form]; [Selenium analog co-treated with Magnesium Oxide analog] inhibits the reaction [Diazinon results in decreased secretion of INS protein]; Magnesium Oxide analog inhibits the reaction [Diazinon results in decreased secretion of INS protein alternative form]; Magnesium Oxide analog inhibits the reaction [Diazinon results in decreased secretion of INS protein] CTD PMID:27920530 NCBI chr 1:215,856,967...215,858,034
Ensembl chr 1:215,856,971...215,858,034
JBrowse link
G Tnfrsf10b TNF receptor superfamily member 10b multiple interactions ISO Magnesium Oxide analog promotes the reaction [Diazinon results in decreased expression of TNFRSF10A mRNA] CTD PMID:27920530 NCBI chr15:51,433,853...51,464,215 JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A multiple interactions ISO [Selenium analog co-treated with Magnesium Oxide analog] inhibits the reaction [Diazinon results in increased expression of TNFRSF1A mRNA]; Magnesium Oxide analog inhibits the reaction [Diazinon results in increased expression of TNFRSF1A mRNA] CTD PMID:27920530 NCBI chr 4:157,864,905...157,877,634
Ensembl chr 4:157,864,969...157,877,633
JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO [Selenium analog co-treated with Magnesium Oxide analog] inhibits the reaction [Diazinon results in increased expression of TP53 mRNA]; Magnesium Oxide analog inhibits the reaction [Diazinon results in increased expression of TP53 mRNA] CTD PMID:27920530 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Traf2 Tnf receptor-associated factor 2 multiple interactions ISO Magnesium Oxide analog inhibits the reaction [Diazinon results in increased expression of TRAF2 mRNA] CTD PMID:27920530 NCBI chr 3:2,746,061...2,770,690
Ensembl chr 3:2,746,075...2,770,620
JBrowse link
magnesium sulfate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bche butyrylcholinesterase multiple interactions EXP Magnesium Sulfate promotes the reaction [Dichlorvos results in decreased activity of BCHE protein] CTD PMID:19504058 NCBI chr 2:171,104,476...171,196,186
Ensembl chr 2:171,100,140...171,196,395
JBrowse link
G Cat catalase multiple interactions EXP Magnesium Sulfate promotes the reaction [Vanadates results in decreased activity of CAT protein] CTD PMID:29453945 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Gsr glutathione-disulfide reductase decreases activity
multiple interactions
EXP Magnesium Sulfate results in decreased activity of GSR protein
[Magnesium Sulfate co-treated with Vanadates] results in decreased activity of GSR protein
CTD PMID:29453945 NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361
JBrowse link
G Il1b interleukin 1 beta decreases expression ISO Magnesium Sulfate results in decreased expression of IL1B mRNA CTD PMID:29594315 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Kcnc2 potassium voltage-gated channel subfamily C member 2 decreases expression EXP Magnesium Sulfate results in decreased expression of KCNC2 mRNA; Magnesium Sulfate results in decreased expression of KCNC2 protein CTD PMID:18775767 NCBI chr 7:54,978,453...55,159,362
Ensembl chr 7:54,980,120...55,159,351
JBrowse link
G Klk8 kallikrein related-peptidase 8 increases activity ISO Magnesium Sulfate results in increased activity of KLK8 protein CTD PMID:16800733 NCBI chr 1:99,735,168...99,742,011
Ensembl chr 1:99,734,993...99,742,009
JBrowse link
G Ren renin increases activity ISO Magnesium Sulfate results in increased activity of REN protein CTD PMID:1874207 NCBI chr13:50,502,724...50,513,953
Ensembl chr13:50,502,724...50,514,151
JBrowse link
G Trpm5 transient receptor potential cation channel, subfamily M, member 5 affects response to substance ISO TRPM5 protein affects the susceptibility to Magnesium Sulfate CTD PMID:19244541 NCBI chr 1:216,256,653...216,281,504
Ensembl chr 1:216,257,820...216,274,930
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    chemical entity 19787
      atom 19784
        metal atom 17263
          alkaline earth metal atom 691
            magnesium atom 97
              magnesium molecular entity + 48
              magnesium-25 atom 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  metal atom 17263
                    alkaline earth metal atom 691
                      magnesium atom 97
                        magnesium molecular entity + 48
                        magnesium-25 atom 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.