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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:ketose
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Accession:CHEBI:24978 term browser browse the term
Definition:Ketonic parent sugars (polyhydroxy ketones H[CH(OH)]nC(=O)[CH(OH)]mH) and their intramolecular hemiketals.
Synonyms:related_synonym: ketoses
 alt_id: CHEBI:6131


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3-deoxyglucosone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1b8 aldo-keto reductase family 1, member B8 multiple interactions ISO [AKR1B8 protein co-treated with NADP] affects the reduction of 3-deoxyglucosone CTD PMID:18845131 NCBI chr 6:34,354,146...34,368,461
Ensembl chr 6:34,354,119...34,368,463
JBrowse link
beta-D-fructofuranose 1,6-bisphosphate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gapdh glyceraldehyde-3-phosphate dehydrogenase multiple interactions ISO [GAPDH protein co-treated with fructose-1,6-diphosphate co-treated with NAD] results in increased chemical synthesis of sodium arsenite; [GAPDH protein co-treated with fructose-1,6-diphosphate co-treated with NAD] results in increased reduction of sodium arsenate analog; heptelidic acid inhibits the reaction [[GAPDH protein co-treated with fructose-1,6-diphosphate co-treated with NAD] results in increased reduction of sodium arsenate analog] CTD PMID:15788719 NCBI chr 6:125,161,852...125,166,467
Ensembl chr 6:125,161,715...125,166,467
JBrowse link
G Idh2 isocitrate dehydrogenase 2 (NADP+), mitochondrial multiple interactions
increases abundance
EXP Triazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of fructose-1,6-diphosphate] CTD PMID:27469509 NCBI chr 7:80,094,845...80,118,608
Ensembl chr 7:80,094,846...80,115,392
JBrowse link
G Mapk1 mitogen-activated protein kinase 1 multiple interactions EXP fructose-1,6-diphosphate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein] CTD PMID:22227475 NCBI chr16:16,983,382...17,047,453
Ensembl chr16:16,983,382...17,047,453
JBrowse link
G Mapk3 mitogen-activated protein kinase 3 multiple interactions EXP fructose-1,6-diphosphate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein] CTD PMID:22227475 NCBI chr 7:126,759,626...126,765,816
Ensembl chr 7:126,759,601...126,765,819
JBrowse link
G Nos2 nitric oxide synthase 2, inducible multiple interactions
decreases degradation
EXP fructose-1,6-diphosphate inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; fructose-1,6-diphosphate inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]
fructose-1,6-diphosphate results in decreased degradation of NOS2 mRNA
CTD PMID:22227475 NCBI chr11:78,920,787...78,960,226
Ensembl chr11:78,920,787...78,960,254
JBrowse link
beta-D-fructofuranose 2,6-bisphosphate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pfkm phosphofructokinase, muscle multiple interactions ISO fructose 2,6-diphosphate inhibits the reaction [resveratrol results in decreased activity of PFKM protein] CTD PMID:23454376 NCBI chr15:98,092,589...98,132,447
Ensembl chr15:98,092,589...98,132,451
JBrowse link
D-fructofuranose 1,6-bisphosphate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gapdh glyceraldehyde-3-phosphate dehydrogenase multiple interactions ISO [GAPDH protein co-treated with fructose-1,6-diphosphate co-treated with NAD] results in increased chemical synthesis of sodium arsenite; [GAPDH protein co-treated with fructose-1,6-diphosphate co-treated with NAD] results in increased reduction of sodium arsenate analog; heptelidic acid inhibits the reaction [[GAPDH protein co-treated with fructose-1,6-diphosphate co-treated with NAD] results in increased reduction of sodium arsenate analog] CTD PMID:15788719 NCBI chr 6:125,161,852...125,166,467
Ensembl chr 6:125,161,715...125,166,467
JBrowse link
G Idh2 isocitrate dehydrogenase 2 (NADP+), mitochondrial multiple interactions
increases abundance
EXP Triazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of fructose-1,6-diphosphate] CTD PMID:27469509 NCBI chr 7:80,094,845...80,118,608
Ensembl chr 7:80,094,846...80,115,392
JBrowse link
G Mapk1 mitogen-activated protein kinase 1 multiple interactions EXP fructose-1,6-diphosphate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein] CTD PMID:22227475 NCBI chr16:16,983,382...17,047,453
Ensembl chr16:16,983,382...17,047,453
JBrowse link
G Mapk3 mitogen-activated protein kinase 3 multiple interactions EXP fructose-1,6-diphosphate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein] CTD PMID:22227475 NCBI chr 7:126,759,626...126,765,816
Ensembl chr 7:126,759,601...126,765,819
JBrowse link
G Nos2 nitric oxide synthase 2, inducible multiple interactions
decreases degradation
EXP fructose-1,6-diphosphate inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; fructose-1,6-diphosphate inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]
fructose-1,6-diphosphate results in decreased degradation of NOS2 mRNA
CTD PMID:22227475 NCBI chr11:78,920,787...78,960,226
Ensembl chr11:78,920,787...78,960,254
JBrowse link
D-xylulose 5-phosphate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Taldo1 transaldolase 1 increases abundance EXP TALDO1 gene mutant form results in increased abundance of xylulose-5-phosphate CTD PMID:19436114 NCBI chr 7:141,392,160...141,402,976
Ensembl chr 7:141,392,199...141,402,968
JBrowse link
dihydroxyacetone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atm ataxia telangiectasia mutated decreases expression ISO Dihydroxyacetone results in decreased expression of ATM mRNA CTD PMID:32506039 NCBI chr 9:53,437,122...53,536,828
Ensembl chr 9:53,439,149...53,536,740
JBrowse link
G Casp3 caspase 3 increases cleavage ISO Dihydroxyacetone results in increased cleavage of CASP3 protein CTD PMID:29193605 NCBI chr 8:46,617,291...46,639,698
Ensembl chr 8:46,617,291...46,639,689
JBrowse link
G Ccl21a chemokine (C-C motif) ligand 21A (serine) decreases expression ISO Dihydroxyacetone results in decreased expression of CCL21 mRNA CTD PMID:32506039 NCBI chr 4:42,772,860...42,773,991
Ensembl chr 4:42,772,860...42,773,993
JBrowse link
G Ccl3 chemokine (C-C motif) ligand 3 decreases expression ISO Dihydroxyacetone results in decreased expression of CCL3 mRNA CTD PMID:32506039 NCBI chr11:83,647,843...83,649,378
Ensembl chr11:83,647,844...83,649,355
JBrowse link
G Ccl4 chemokine (C-C motif) ligand 4 decreases expression ISO Dihydroxyacetone results in decreased expression of CCL4 mRNA CTD PMID:32506039 NCBI chr11:83,648,624...83,664,683
Ensembl chr11:83,662,584...83,664,683
JBrowse link
G Ccnc cyclin C increases expression ISO Dihydroxyacetone results in increased expression of CCNC mRNA CTD PMID:32506039 NCBI chr 4:21,727,701...21,759,922
Ensembl chr 4:21,727,701...21,759,922
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A (P21) decreases expression ISO Dihydroxyacetone results in decreased expression of CDKN1A mRNA CTD PMID:32506039 NCBI chr17:29,090,979...29,100,722
Ensembl chr17:29,090,976...29,100,727
JBrowse link
G Cel carboxyl ester lipase increases expression EXP
ISO
Dihydroxyacetone results in increased expression of CEL protein CTD PMID:32506039 NCBI chr 2:28,555,819...28,563,403
Ensembl chr 2:28,555,795...28,563,403
JBrowse link
G Chek2 checkpoint kinase 2 decreases expression ISO Dihydroxyacetone results in decreased expression of CHEK2 mRNA CTD PMID:32506039 NCBI chr 5:110,839,800...110,874,140
Ensembl chr 5:110,839,979...110,874,145
JBrowse link
G Cryab crystallin, alpha B increases expression ISO Dihydroxyacetone results in increased expression of CRYAB mRNA; Dihydroxyacetone results in increased expression of CRYAB protein CTD PMID:32506039 NCBI chr 9:50,745,951...50,756,636
Ensembl chr 9:50,751,325...50,756,636
JBrowse link
G Csf2 colony stimulating factor 2 (granulocyte-macrophage) increases expression ISO Dihydroxyacetone results in increased expression of CSF2 mRNA CTD PMID:32506039 NCBI chr11:54,247,270...54,249,899
Ensembl chr11:54,247,271...54,249,667
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases expression ISO Dihydroxyacetone results in decreased expression of CYP1A1 mRNA CTD PMID:32506039 NCBI chr 9:57,687,928...57,703,824
Ensembl chr 9:57,687,928...57,703,824
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 decreases expression ISO Dihydroxyacetone results in decreased expression of CYP2E1 mRNA CTD PMID:32506039 NCBI chr 7:140,763,819...140,774,990
Ensembl chr 7:140,763,739...140,774,987
JBrowse link
G Cyp7a1 cytochrome P450, family 7, subfamily a, polypeptide 1 decreases expression ISO Dihydroxyacetone results in decreased expression of CYP7A1 mRNA CTD PMID:32506039 NCBI chr 4:6,265,612...6,275,632
Ensembl chr 4:6,265,612...6,275,633
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO Dihydroxyacetone results in increased expression of DDIT3 mRNA CTD PMID:32506039 NCBI chr10:127,290,793...127,296,291
Ensembl chr10:127,290,774...127,296,288
Ensembl chr10:127,290,774...127,296,288
JBrowse link
G Dnajb4 DnaJ heat shock protein family (Hsp40) member B4 increases expression ISO Dihydroxyacetone results in increased expression of DNAJB4 mRNA CTD PMID:32506039 NCBI chr 3:152,181,580...152,210,432
Ensembl chr 3:152,178,511...152,210,302
JBrowse link
G E2f1 E2F transcription factor 1 increases expression ISO Dihydroxyacetone results in increased expression of E2F1 mRNA CTD PMID:32506039 NCBI chr 2:154,559,400...154,569,892
Ensembl chr 2:154,559,407...154,569,892
JBrowse link
G Egr1 early growth response 1 affects expression ISO Dihydroxyacetone affects the expression of EGR1 mRNA CTD PMID:32506039 NCBI chr18:34,861,207...34,864,956
Ensembl chr18:34,859,823...34,864,984
JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2, subunit 1 alpha increases phosphorylation ISO Dihydroxyacetone results in increased phosphorylation of EIF2S1 protein CTD PMID:32506039 NCBI chr12:78,862,072...78,887,010
Ensembl chr12:78,861,819...78,887,010
JBrowse link
G Ephx2 epoxide hydrolase 2, cytoplasmic decreases expression ISO Dihydroxyacetone results in decreased expression of EPHX2 mRNA CTD PMID:32506039 NCBI chr14:66,084,372...66,124,522
Ensembl chr14:66,084,374...66,124,500
JBrowse link
G Ercc3 excision repair cross-complementing rodent repair deficiency, complementation group 3 increases expression ISO Dihydroxyacetone results in increased expression of ERCC3 mRNA CTD PMID:32506039 NCBI chr18:32,240,304...32,270,151
Ensembl chr18:32,240,300...32,270,151
JBrowse link
G Fasl Fas ligand (TNF superfamily, member 6) affects expression ISO Dihydroxyacetone affects the expression of FASLG mRNA CTD PMID:32506039 NCBI chr 1:161,780,691...161,788,495
Ensembl chr 1:161,780,689...161,788,495
JBrowse link
G Fmo1 flavin containing monooxygenase 1 decreases expression ISO Dihydroxyacetone results in decreased expression of FMO1 mRNA CTD PMID:32506039 NCBI chr 1:162,829,561...162,866,610
Ensembl chr 1:162,829,561...162,866,610
JBrowse link
G Gdf15 growth differentiation factor 15 decreases expression ISO Dihydroxyacetone results in decreased expression of GDF15 mRNA CTD PMID:32506039 NCBI chr 8:70,629,393...70,632,470
Ensembl chr 8:70,629,393...70,632,456
JBrowse link
G Glo1 glyoxalase 1 affects response to substance ISO GLO1 protein affects the susceptibility to Dihydroxyacetone CTD PMID:32506039 NCBI chr17:30,592,861...30,612,659
Ensembl chr17:30,584,936...30,626,871
JBrowse link
G H2ax H2A.X variant histone increases expression ISO Dihydroxyacetone results in increased expression of H2AX protein CTD PMID:32506039 NCBI chr 9:44,334,715...44,336,077
Ensembl chr 9:44,334,694...44,336,077
JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO
EXP
Dihydroxyacetone results in increased expression of HMOX1 mRNA; Dihydroxyacetone results in increased expression of HMOX1 protein CTD PMID:32506039 NCBI chr 8:75,093,618...75,100,593
Ensembl chr 8:75,093,621...75,100,589
JBrowse link
G Hspa1a heat shock protein 1A increases expression ISO Dihydroxyacetone results in increased expression of HSPA1A mRNA CTD PMID:32506039 NCBI chr17:34,969,359...34,972,156
Ensembl chr17:34,969,190...34,972,156
JBrowse link
G Hspa2 heat shock protein 2 increases expression ISO Dihydroxyacetone results in increased expression of HSPA2 mRNA CTD PMID:32506039 NCBI chr12:76,403,812...76,406,938
Ensembl chr12:76,404,176...76,406,938
JBrowse link
G Hspb1 heat shock protein 1 increases phosphorylation ISO Dihydroxyacetone results in increased phosphorylation of HSPB1 protein CTD PMID:32506039 NCBI chr 5:135,887,919...135,889,563
Ensembl chr 5:135,887,919...135,889,563
JBrowse link
G Hspd1 heat shock protein 1 (chaperonin) increases expression ISO Dihydroxyacetone results in increased expression of HSPD1 mRNA CTD PMID:32506039 NCBI chr 1:55,077,833...55,088,243
Ensembl chr 1:55,077,835...55,088,243
JBrowse link
G Hspe1 heat shock protein 1 (chaperonin 10) increases expression ISO Dihydroxyacetone results in increased expression of HSPE1 mRNA CTD PMID:32506039 NCBI chr 1:55,088,148...55,091,317
Ensembl chr 1:55,088,132...55,091,307
JBrowse link
G Il6 interleukin 6 increases expression ISO Dihydroxyacetone results in increased expression of IL6 mRNA CTD PMID:32506039 NCBI chr 5:30,013,114...30,019,975
Ensembl chr 5:30,013,114...30,019,981
JBrowse link
G Mapk1 mitogen-activated protein kinase 1 increases phosphorylation ISO Dihydroxyacetone results in increased phosphorylation of MAPK1 protein CTD PMID:32506039 NCBI chr16:16,983,382...17,047,453
Ensembl chr16:16,983,382...17,047,453
JBrowse link
G Mapk3 mitogen-activated protein kinase 3 increases phosphorylation ISO Dihydroxyacetone results in increased phosphorylation of MAPK3 protein CTD PMID:32506039 NCBI chr 7:126,759,626...126,765,816
Ensembl chr 7:126,759,601...126,765,819
JBrowse link
G Mmp10 matrix metallopeptidase 10 decreases secretion ISO Dihydroxyacetone results in decreased secretion of MMP10 protein CTD PMID:30959092 NCBI chr 9:7,502,342...7,510,242
Ensembl chr 9:7,502,352...7,510,240
JBrowse link
G Mmp13 matrix metallopeptidase 13 decreases secretion ISO Dihydroxyacetone results in decreased secretion of MMP13 protein CTD PMID:30959092 NCBI chr 9:7,272,514...7,283,333
Ensembl chr 9:7,272,514...7,283,331
JBrowse link
G Mt2 metallothionein 2 decreases expression ISO Dihydroxyacetone results in decreased expression of MT2A mRNA CTD PMID:32506039 NCBI chr 8:94,172,618...94,173,567
Ensembl chr 8:94,172,664...94,173,568
JBrowse link
G Muc5ac mucin 5, subtypes A and C, tracheobronchial/gastric decreases secretion ISO Dihydroxyacetone results in decreased secretion of MUC5AC protein CTD PMID:30959092 NCBI chr 7:141,788,958...141,819,227
Ensembl chr 7:141,788,972...141,819,231
JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 increases expression ISO Dihydroxyacetone results in increased expression of NFE2L2 protein CTD PMID:32506039 NCBI chr 2:75,675,513...75,704,663
Ensembl chr 2:75,675,513...75,704,641
JBrowse link
G Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 decreases expression ISO Dihydroxyacetone results in decreased expression of NFKB1 mRNA CTD PMID:32506039 NCBI chr 3:135,584,655...135,691,969
Ensembl chr 3:135,584,655...135,691,547
JBrowse link
G Nos2 nitric oxide synthase 2, inducible decreases expression ISO Dihydroxyacetone results in decreased expression of NOS2 mRNA CTD PMID:32506039 NCBI chr11:78,920,787...78,960,226
Ensembl chr11:78,920,787...78,960,254
JBrowse link
G Oat ornithine aminotransferase multiple interactions ISO Dihydroxyacetone inhibits the reaction [Cyclic AMP results in increased activity of OAT protein] CTD PMID:2827574 NCBI chr 7:132,557,475...132,576,398
Ensembl chr 7:132,557,478...132,576,398
JBrowse link
G Parp1 poly (ADP-ribose) polymerase family, member 1 increases cleavage ISO Dihydroxyacetone results in increased cleavage of PARP1 protein CTD PMID:29193605 NCBI chr 1:180,568,891...180,600,999
Ensembl chr 1:180,568,924...180,601,254
JBrowse link
G Pcna proliferating cell nuclear antigen increases expression ISO Dihydroxyacetone results in increased expression of PCNA mRNA CTD PMID:32506039 NCBI chr 2:132,249,286...132,253,180
Ensembl chr 2:132,249,162...132,253,314
JBrowse link
G Tnf tumor necrosis factor increases expression ISO Dihydroxyacetone results in increased expression of TNF mRNA CTD PMID:32506039 NCBI chr17:35,199,367...35,202,007
Ensembl chr17:35,199,381...35,202,007
JBrowse link
G Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a affects expression ISO Dihydroxyacetone affects the expression of TNFRSF1A mRNA CTD PMID:32506039 NCBI chr 6:125,349,723...125,362,483
Ensembl chr 6:125,349,362...125,362,484
JBrowse link
G Tnfsf10 tumor necrosis factor (ligand) superfamily, member 10 decreases expression ISO Dihydroxyacetone results in decreased expression of TNFSF10 mRNA CTD PMID:32506039 NCBI chr 3:27,317,077...27,339,665
Ensembl chr 3:27,317,028...27,342,427
JBrowse link
G Ung uracil DNA glycosylase decreases expression ISO Dihydroxyacetone results in decreased expression of UNG mRNA CTD PMID:32506039 NCBI chr 5:114,130,366...114,139,321
Ensembl chr 5:114,130,386...114,139,323
JBrowse link
G Xrcc2 X-ray repair complementing defective repair in Chinese hamster cells 2 increases expression ISO Dihydroxyacetone results in increased expression of XRCC2 mRNA; Dihydroxyacetone results in increased expression of XRCC2 protein CTD PMID:32506039 NCBI chr 5:25,689,814...25,705,797
Ensembl chr 5:25,689,812...25,705,825
JBrowse link
dihydroxyacetone phosphate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Idh2 isocitrate dehydrogenase 2 (NADP+), mitochondrial multiple interactions
increases abundance
EXP Triazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of Dihydroxyacetone Phosphate] CTD PMID:27469509 NCBI chr 7:80,094,845...80,118,608
Ensembl chr 7:80,094,846...80,115,392
JBrowse link
G Tpi1 triosephosphate isomerase 1 affects metabolic processing ISO TPI1 protein affects the metabolism of Dihydroxyacetone Phosphate CTD PMID:14762718 NCBI chr 6:124,810,586...124,814,158
Ensembl chr 6:124,810,586...124,814,296
JBrowse link
fructose term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A1bg alpha-1-B glycoprotein multiple interactions ISO [Fructose co-treated with bisphenol A] results in decreased expression of A1BG protein CTD PMID:26930160 NCBI chr15:60,917,589...60,921,270
Ensembl chr15:60,896,859...60,923,012
JBrowse link
G Abca1 ATP-binding cassette, sub-family A (ABC1), member 1 multiple interactions
increases expression
ISO Tea inhibits the reaction [Fructose results in increased expression of ABCA1 mRNA] CTD PMID:19193814 NCBI chr 4:53,030,789...53,159,988
Ensembl chr 4:53,030,787...53,159,895
JBrowse link
G Abcc2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 multiple interactions
decreases expression
ISO Ascorbic Acid inhibits the reaction [Fructose results in decreased expression of ABCC2 mRNA]; Ascorbic Acid inhibits the reaction [Fructose results in decreased expression of ABCC2 protein]; geraniol inhibits the reaction [Fructose results in decreased expression of ABCC2 mRNA]; geraniol inhibits the reaction [Fructose results in decreased expression of ABCC2 protein]
Fructose results in decreased expression of ABCC2 mRNA; Fructose results in decreased expression of ABCC2 protein
CTD PMID:31005848 NCBI chr19:43,782,308...43,838,332
Ensembl chr19:43,782,192...43,840,740
JBrowse link
G Acaca acetyl-Coenzyme A carboxylase alpha multiple interactions
decreases phosphorylation
increases expression
EXP
ISO
FGF21 gene mutant form inhibits the reaction [Fructose results in increased expression of ACACA mRNA]; Phenylbutyrates inhibits the reaction [Fructose results in increased expression of ACACA mRNA]; SCD1 gene mutant form inhibits the reaction [Fructose results in increased expression of ACACA mRNA]; Triolein inhibits the reaction [SCD1 gene mutant form inhibits the reaction [Fructose results in increased expression of ACACA mRNA]]; Triolein promotes the reaction [Fructose results in increased expression of ACACA mRNA]
[Fructose co-treated with Palmitic Acid] results in decreased expression of ACACA protein modified form; [Fructose co-treated with Palmitic Acid] results in increased expression of ACACA protein; Fenofibrate inhibits the reaction [[Fructose co-treated with Palmitic Acid] results in decreased expression of ACACA protein modified form]; Fenofibrate inhibits the reaction [[Fructose co-treated with Palmitic Acid] results in increased expression of ACACA protein]
Fructose results in decreased phosphorylation of ACACA protein
[6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in decreased activity of SIRT1 protein] inhibits the reaction [Fructose results in increased expression of ACACA mRNA]; [Niacinamide results in decreased activity of SIRT1 protein] inhibits the reaction [Fructose results in increased expression of ACACA mRNA]; Fructose inhibits the reaction [Streptozocin results in decreased activity of ACACA protein]; Fructose inhibits the reaction [Streptozocin results in decreased expression of ACACA mRNA]; Rotenone inhibits the reaction [Fructose results in increased expression of ACACA mRNA]
CTD PMID:1973097 PMID:15066988 PMID:21212096 PMID:22698815 PMID:28123933 PMID:31672515 PMID:32730863 NCBI chr11:84,129,635...84,401,651
Ensembl chr11:84,129,672...84,401,651
JBrowse link
G Acacb acetyl-Coenzyme A carboxylase beta decreases expression
multiple interactions
increases expression
ISO
EXP
Fructose results in decreased expression of ACACB mRNA
FGF21 gene mutant form inhibits the reaction [Fructose results in increased expression of ACACB mRNA]
CTD PMID:18063403 PMID:19053045 PMID:28123933 NCBI chr 5:114,146,321...114,250,761
Ensembl chr 5:114,146,535...114,250,761
JBrowse link
G Acadl acyl-Coenzyme A dehydrogenase, long-chain multiple interactions ISO [Fructose co-treated with Copper deficiency] results in decreased expression of ACADL mRNA CTD PMID:25813056 NCBI chr 1:66,830,839...66,863,309
Ensembl chr 1:66,830,839...66,863,277
JBrowse link
G Acadm acyl-Coenzyme A dehydrogenase, medium chain multiple interactions ISO [Fructose co-treated with Copper deficiency] results in decreased expression of ACADM mRNA CTD PMID:25813056 NCBI chr 3:153,922,353...153,944,643
Ensembl chr 3:153,922,357...153,944,632
JBrowse link
G Acads acyl-Coenzyme A dehydrogenase, short chain multiple interactions ISO [Fructose co-treated with bisphenol A] results in decreased expression of ACADS protein CTD PMID:26930160 NCBI chr 5:115,110,299...115,119,346
Ensembl chr 5:115,110,299...115,119,346
JBrowse link
G Acadvl acyl-Coenzyme A dehydrogenase, very long chain multiple interactions ISO [Fructose co-treated with bisphenol A] results in increased expression of ACADVL protein; [Fructose co-treated with Copper deficiency] results in decreased expression of ACADVL mRNA CTD PMID:25813056 PMID:26930160 NCBI chr11:70,010,183...70,015,428
Ensembl chr11:70,010,183...70,015,411
JBrowse link
G Ace angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 increases expression
multiple interactions
ISO Fructose results in increased expression of ACE mRNA
[bisphenol A co-treated with Fructose] results in increased expression of ACE mRNA; APLN protein modified form inhibits the reaction [Fructose results in increased expression of ACE mRNA]
CTD PMID:17587757 PMID:27622962 PMID:30710622 NCBI chr11:105,967,948...105,989,964
Ensembl chr11:105,967,945...105,989,964
JBrowse link
G Acly ATP citrate lyase increases expression ISO Fructose results in increased expression of ACLY mRNA CTD PMID:1396700 NCBI chr11:100,476,352...100,528,000
Ensembl chr11:100,476,353...100,528,000
JBrowse link
G Acox1 acyl-Coenzyme A oxidase 1, palmitoyl multiple interactions
decreases expression
ISO Atorvastatin inhibits the reaction [Fructose results in decreased expression of ACOX1 mRNA] CTD PMID:21122807 NCBI chr11:116,171,883...116,199,045
Ensembl chr11:116,171,888...116,199,045
JBrowse link
G Acsf2 acyl-CoA synthetase family member 2 multiple interactions ISO [Fructose co-treated with bisphenol A] results in increased expression of ACSF2 protein CTD PMID:26930160 NCBI chr11:94,557,102...94,602,139
Ensembl chr11:94,557,102...94,601,871
JBrowse link
G Acta2 actin alpha 2, smooth muscle, aorta increases expression
multiple interactions
ISO Fructose results in increased expression of ACTA2 protein
[Streptozocin co-treated with Fructose] results in increased expression of ACTA2 protein; dapagliflozin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of ACTA2 protein]; Genistein inhibits the reaction [Fructose results in increased expression of ACTA2 protein]; Metformin promotes the reaction [dapagliflozin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of ACTA2 protein]]
CTD PMID:21704028 PMID:30551545 NCBI chr19:34,240,336...34,255,585
Ensembl chr19:34,241,090...34,255,590
JBrowse link
G Ada adenosine deaminase increases activity
multiple interactions
ISO Fructose results in increased activity of ADA protein
Glutamine inhibits the reaction [Fructose results in increased activity of ADA protein]
CTD PMID:31233715 NCBI chr 2:163,726,571...163,750,239
Ensembl chr 2:163,726,584...163,750,239
JBrowse link
G Adgre1 adhesion G protein-coupled receptor E1 multiple interactions
increases expression
ISO
EXP
[gadolinium chloride co-treated with Fructose co-treated with Copper deficiency] results in decreased expression of ADGRE1 mRNA
Fructose results in increased expression of ADGRE1 protein
Ethanol promotes the reaction [Fructose results in increased expression of ADGRE1 protein]; Fructose promotes the reaction [Ethanol results in increased expression of ADGRE1 mRNA]; Fructose promotes the reaction [Ethanol results in increased expression of ADGRE1 protein]
CTD PMID:25813056 PMID:26858005 NCBI chr17:57,358,581...57,483,529
Ensembl chr17:57,358,691...57,483,527
JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing multiple interactions
decreases secretion
increases secretion
decreases expression
increases expression
ISO
EXP
[Particulate Matter co-treated with Ozone] promotes the reaction [Fructose results in decreased expression of ADIPOQ mRNA]; Curcumin inhibits the reaction [Fructose results in decreased expression of ADIPOQ protein]; geraniol inhibits the reaction [Fructose results in decreased secretion of ADIPOQ protein]; Metformin inhibits the reaction [Fructose results in decreased expression of ADIPOQ protein]; Ozone promotes the reaction [Fructose results in decreased expression of ADIPOQ mRNA]; Particulate Matter promotes the reaction [Fructose results in decreased expression of ADIPOQ mRNA]; Pioglitazone inhibits the reaction [Fructose results in decreased secretion of ADIPOQ protein]; Resveratrol inhibits the reaction [Fructose results in decreased expression of ADIPOQ mRNA]; Resveratrol inhibits the reaction [Fructose results in decreased expression of ADIPOQ protein]; sapropterin inhibits the reaction [Fructose results in decreased expression of ADIPOQ mRNA]; sapropterin inhibits the reaction [Fructose results in decreased expression of ADIPOQ protein]
Fructose results in increased secretion of ADIPOQ protein
Fructose results in decreased expression of ADIPOQ mRNA; Fructose results in decreased expression of ADIPOQ protein
Fructose results in increased expression of ADIPOQ mRNA; Fructose results in increased expression of ADIPOQ protein
CTD PMID:17098227 PMID:19165636 PMID:21122807 PMID:23016136 PMID:23968387 PMID:25108154 PMID:25679220 PMID:26713546 PMID:26973390 PMID:28257781 NCBI chr16:23,146,536...23,157,968
Ensembl chr16:23,146,536...23,158,028
JBrowse link
G Adipor2 adiponectin receptor 2 decreases expression EXP Fructose results in decreased expression of ADIPOR2 protein CTD PMID:28257781 NCBI chr 6:119,353,150...119,417,699
Ensembl chr 6:119,353,150...119,417,704
JBrowse link
G Ager advanced glycosylation end product-specific receptor increases expression
multiple interactions
ISO Fructose results in increased expression of AGER protein
Genistein inhibits the reaction [Fructose results in increased expression of AGER protein]; geraniol inhibits the reaction [Fructose results in increased expression of AGER protein]; Pioglitazone inhibits the reaction [Fructose results in increased expression of AGER protein]
CTD PMID:21704028 PMID:25679220 NCBI chr17:34,597,460...34,600,937
Ensembl chr17:34,597,862...34,600,936
JBrowse link
G Agt angiotensinogen (serpin peptidase inhibitor, clade A, member 8) increases expression
multiple interactions
ISO
EXP
Fructose results in increased expression of AGT mRNA; Fructose results in increased expression of AGT protein; Fructose results in increased expression of AGT protein modified form
APLN protein modified form inhibits the reaction [Fructose results in increased expression of AGT mRNA]; APLN protein modified form inhibits the reaction [Fructose results in increased expression of AGT protein modified form]; APLN protein modified form inhibits the reaction [Fructose results in increased expression of AGT protein]
CTD PMID:11741341 PMID:16843071 PMID:17587757 PMID:18360027 PMID:30710622 NCBI chr 8:124,556,587...124,569,706
Ensembl chr 8:124,556,534...124,569,706
JBrowse link
G Agtr1a angiotensin II receptor, type 1a increases expression
multiple interactions
EXP
ISO
Fructose results in increased expression of AGTR1A mRNA
Fructose results in increased expression of AGTR1 mRNA
APLN protein modified form inhibits the reaction [Fructose results in increased expression of AGTR1A mRNA]; INS protein inhibits the reaction [Fructose results in increased expression of AGTR1A mRNA]
CTD PMID:16843071 PMID:17587757 PMID:18360027 PMID:30710622 PMID:31655124 NCBI chr13:30,336,356...30,382,867
Ensembl chr13:30,336,441...30,382,867
JBrowse link
G Agtr1b angiotensin II receptor, type 1b increases expression
multiple interactions
ISO Fructose results in increased expression of AGTR1B mRNA
KLK1 protein inhibits the reaction [Fructose results in increased expression of AGTR1B mRNA]
CTD PMID:14568997 NCBI chr 3:20,314,473...20,367,177
Ensembl chr 3:20,314,473...20,367,177
JBrowse link
G Agtr2 angiotensin II receptor, type 2 multiple interactions
increases expression
ISO APLN protein modified form inhibits the reaction [Fructose results in increased expression of AGTR2 mRNA] CTD PMID:30710622 NCBI chr  X:21,484,624...21,488,833
Ensembl chr  X:21,484,544...21,489,164
JBrowse link
G Ahr aryl-hydrocarbon receptor multiple interactions EXP [Dietary Fats co-treated with Fructose] results in increased expression of AHR mRNA; AHR protein results in increased susceptibility to [Dietary Fats co-treated with Fructose]; NR0B2 protein inhibits the reaction [AHR protein results in increased susceptibility to [Dietary Fats co-treated with Fructose]]; PEMT protein promotes the reaction [AHR protein results in increased susceptibility to [Dietary Fats co-treated with Fructose]] CTD PMID:29416063 NCBI chr12:35,497,979...35,534,989
Ensembl chr12:35,497,974...35,535,038
JBrowse link
G Akr1b3 aldo-keto reductase family 1, member B3 (aldose reductase) multiple interactions ISO [Fructose co-treated with bisphenol A] results in increased expression of AKR1B1 protein CTD PMID:26930160 NCBI chr 6:34,303,930...34,317,489
Ensembl chr 6:34,302,434...34,317,478
JBrowse link
G Akt1 thymoma viral proto-oncogene 1 decreases phosphorylation
increases phosphorylation
multiple interactions
ISO Fructose results in decreased phosphorylation of AKT1 protein
Fructose results in increased phosphorylation of AKT1 protein
[dapagliflozin co-treated with Atorvastatin] inhibits the reaction [[Fructose co-treated with Dietary Fats] results in decreased expression of AKT1 protein]; [Fructose co-treated with Dietary Fats] results in decreased expression of and results in decreased phosphorylation of AKT1 protein; [Fructose co-treated with Oleanolic Acid] results in increased expression of AKT1 mRNA; NOS3 protein inhibits the reaction [Fructose results in decreased phosphorylation of AKT1 protein]; Quercetin inhibits the reaction [Fructose results in decreased phosphorylation of AKT1 protein]; Quercetin inhibits the reaction [Fructose results in increased phosphorylation of AKT1 protein]; Rutin inhibits the reaction [Fructose results in decreased phosphorylation of AKT1 protein]
CTD PMID:18497449 PMID:19008412 PMID:22426011 PMID:23533474 PMID:24704288 PMID:32259528 NCBI chr12:112,653,821...112,674,884
Ensembl chr12:112,653,821...112,674,884
JBrowse link
G Aldob aldolase B, fructose-bisphosphate increases expression
multiple interactions
EXP
ISO
Fructose results in increased expression of ALDOB mRNA
FGF21 gene mutant form inhibits the reaction [Fructose results in increased expression of ALDOB mRNA]
CTD PMID:15066988 PMID:18346472 PMID:28123933 NCBI chr 4:49,535,993...49,549,546
Ensembl chr 4:49,535,995...49,549,546
JBrowse link
G Alox5 arachidonate 5-lipoxygenase increases expression ISO Fructose results in increased expression of ALOX5 mRNA CTD PMID:31655124 NCBI chr 6:116,410,071...116,461,178
Ensembl chr 6:116,410,077...116,461,178
JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 multiple interactions EXP [Fructose co-treated with Dietary Fats] results in increased expression of APAF1 mRNA; troxerutin inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of APAF1 mRNA] CTD PMID:28916335 NCBI chr10:90,989,311...91,082,743
Ensembl chr10:90,989,311...91,082,770
JBrowse link
G Apln apelin multiple interactions ISO APLN protein modified form inhibits the reaction [Fructose results in decreased activity of CAT protein]; APLN protein modified form inhibits the reaction [Fructose results in decreased expression of APLNR mRNA]; APLN protein modified form inhibits the reaction [Fructose results in increased expression of ACE mRNA]; APLN protein modified form inhibits the reaction [Fructose results in increased expression of AGT mRNA]; APLN protein modified form inhibits the reaction [Fructose results in increased expression of AGT protein modified form]; APLN protein modified form inhibits the reaction [Fructose results in increased expression of AGT protein]; APLN protein modified form inhibits the reaction [Fructose results in increased expression of AGTR1A mRNA]; APLN protein modified form inhibits the reaction [Fructose results in increased expression of AGTR2 mRNA] CTD PMID:30710622 NCBI chr  X:48,025,146...48,034,853
Ensembl chr  X:48,025,146...48,034,853
JBrowse link
G Aplnr apelin receptor decreases expression
multiple interactions
ISO Fructose results in decreased expression of APLNR mRNA
APLN protein modified form inhibits the reaction [Fructose results in decreased expression of APLNR mRNA]
CTD PMID:30710622 NCBI chr 2:85,136,360...85,139,923
Ensembl chr 2:85,136,225...85,139,923
JBrowse link
G Apoa1 apolipoprotein A-I increases expression
multiple interactions
decreases expression
ISO
EXP
Fructose results in increased expression of APOA1 mRNA; Fructose results in increased expression of APOA1 protein
Plant Preparations inhibits the reaction [Fructose results in decreased expression of APOA1 protein]
[bisphenol A co-treated with Fructose] results in increased expression of APOA1 protein
CTD PMID:9322794 PMID:23142792 PMID:27531227 NCBI chr 9:46,228,630...46,230,469
Ensembl chr 9:46,228,580...46,230,466
JBrowse link
G Apoa4 apolipoprotein A-IV increases expression ISO Fructose results in increased expression of APOA4 mRNA CTD PMID:11983814 NCBI chr 9:46,240,844...46,243,458
Ensembl chr 9:46,240,696...46,243,459
JBrowse link
G Apob apolipoprotein B multiple interactions
increases expression
ISO
EXP
[Fructose co-treated with Copper deficiency] results in decreased expression of APOB mRNA; Atorvastatin inhibits the reaction [Fructose results in increased expression of APOB protein]; gadolinium chloride promotes the reaction [[Fructose co-treated with Copper deficiency] results in decreased expression of APOB mRNA]
[FGF21 gene mutant form results in increased susceptibility to Fructose] which results in decreased expression of APOB mRNA; Plant Preparations inhibits the reaction [Fructose results in increased expression of APOB protein]
Fructose results in increased expression of APOB mRNA; Fructose results in increased expression of APOB protein
CTD PMID:8415773 PMID:12065722 PMID:25813056 PMID:27531227 PMID:28123933 NCBI chr12:7,977,629...8,016,839
Ensembl chr12:7,977,648...8,016,835
JBrowse link
G Atf4 activating transcription factor 4 increases expression ISO Fructose results in increased expression of ATF4 mRNA CTD PMID:15150374 NCBI chr15:80,255,184...80,257,545
Ensembl chr15:80,255,184...80,257,541
JBrowse link
G Atp1b1 ATPase, Na+/K+ transporting, beta 1 polypeptide decreases expression ISO Fructose results in decreased expression of ATP1B1 protein CTD PMID:26930160 NCBI chr 1:164,437,099...164,458,355
Ensembl chr 1:164,437,109...164,458,355
JBrowse link
G Atp2a2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 multiple interactions EXP [Fructose co-treated with Dietary Fats] results in decreased expression of ATP2A2 mRNA; troxerutin inhibits the reaction [[Fructose co-treated with Dietary Fats] results in decreased expression of ATP2A2 mRNA] CTD PMID:28916335 NCBI chr 5:122,453,513...122,502,225
Ensembl chr 5:122,453,513...122,502,225
JBrowse link
G Atp5j2 ATP synthase, H+ transporting, mitochondrial F0 complex, subunit F2 multiple interactions
increases expression
ISO [Fructose co-treated with bisphenol A] results in decreased expression of ATP5MF protein
Fructose results in increased expression of ATP5MF protein
CTD PMID:26930160 NCBI chr 5:145,183,704...145,191,541
Ensembl chr 5:145,183,698...145,192,062
JBrowse link
G Bax BCL2-associated X protein increases expression
multiple interactions
EXP Fructose results in increased expression of BAX protein
[Fructose co-treated with Dietary Fats] results in increased expression of BAX mRNA; [Fructose co-treated with Dietary Fats] results in increased expression of BAX protein; Plant Preparations inhibits the reaction [Fructose results in increased expression of BAX protein]; troxerutin inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of BAX mRNA]; troxerutin inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of BAX protein]
CTD PMID:27531227 PMID:28916335 NCBI chr 7:45,461,695...45,466,903
Ensembl chr 7:45,461,697...45,466,898
JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 decreases expression
increases expression
multiple interactions
EXP
ISO
Fructose results in decreased expression of BCL2 protein
Fructose results in increased expression of BCL2 mRNA
[Atorvastatin co-treated with dapagliflozin] inhibits the reaction [[Fructose co-treated with Dietary Fats] results in decreased expression of BCL2 protein]; [Fructose co-treated with Dietary Fats] results in decreased expression of BCL2 protein; dapagliflozin inhibits the reaction [[Fructose co-treated with Dietary Fats] results in decreased expression of BCL2 protein]; Kangen-karyu inhibits the reaction [Fructose results in increased expression of BCL2 protein]
[Fructose co-treated with Dietary Fats] results in decreased expression of BCL2 mRNA; [Fructose co-treated with Dietary Fats] results in decreased expression of BCL2 protein; troxerutin inhibits the reaction [[Fructose co-treated with Dietary Fats] results in decreased expression of BCL2 mRNA]; troxerutin inhibits the reaction [[Fructose co-treated with Dietary Fats] results in decreased expression of BCL2 protein]
CTD PMID:17883899 PMID:27531227 PMID:28916335 PMID:31655124 PMID:32259528 NCBI chr 1:106,538,176...106,714,290
Ensembl chr 1:106,538,178...106,714,274
JBrowse link
G Calca calcitonin/calcitonin-related polypeptide, alpha increases expression ISO Fructose results in increased expression of CALCA mRNA CTD PMID:31655124 NCBI chr 7:114,625,981...114,636,910
Ensembl chr 7:114,631,478...114,636,357
JBrowse link
G Casp1 caspase 1 multiple interactions
increases expression
ISO Allopurinol inhibits the reaction [Fructose results in increased expression of CASP1 protein modified form]; Allopurinol inhibits the reaction [Fructose results in increased expression of CASP1 protein]; Quercetin inhibits the reaction [Fructose results in increased expression of CASP1 protein modified form]; Quercetin inhibits the reaction [Fructose results in increased expression of CASP1 protein]; Rutin inhibits the reaction [Fructose results in increased expression of CASP1 protein]
Fructose results in increased expression of CASP1 protein; Fructose results in increased expression of CASP1 protein modified form
CTD PMID:22426011 PMID:24491314 NCBI chr 9:5,298,517...5,307,281
Ensembl chr 9:5,298,508...5,307,290
JBrowse link
G Casp3 caspase 3 multiple interactions
decreases expression
increases expression
EXP
ISO
[Fructose co-treated with Dietary Fats] results in increased expression of CASP3 mRNA; [Fructose co-treated with Dietary Fats] results in increased expression of CASP3 protein; troxerutin inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of CASP3 mRNA]; troxerutin inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of CASP3 protein]
[Fructose co-treated with Palmitic Acid] results in increased activity of CASP3 protein; Fenofibrate inhibits the reaction [[Fructose co-treated with Palmitic Acid] results in increased activity of CASP3 protein]
Fructose results in decreased expression of CASP3 mRNA
imoxin inhibits the reaction [Fructose results in increased expression of CASP3 protein]
CTD PMID:28916335 PMID:29430716 PMID:31655124 PMID:32730863 NCBI chr 8:46,617,291...46,639,698
Ensembl chr 8:46,617,291...46,639,689
JBrowse link
G Casp7 caspase 7 multiple interactions ISO [Streptozocin co-treated with Fructose] results in increased expression of CASP7 protein; dapagliflozin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of CASP7 protein]; dapagliflozin promotes the reaction [Metformin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of CASP7 protein]]; Metformin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of CASP7 protein]; Metformin promotes the reaction [dapagliflozin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of CASP7 protein]] CTD PMID:30551545 NCBI chr19:56,396,833...56,442,348
Ensembl chr19:56,397,129...56,442,344
JBrowse link
G Casp9 caspase 9 multiple interactions EXP [Fructose co-treated with Dietary Fats] results in increased expression of CASP9 mRNA; [Fructose co-treated with Dietary Fats] results in increased expression of CASP9 protein; troxerutin inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of CASP9 mRNA]; troxerutin inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of CASP9 protein] CTD PMID:28916335 NCBI chr 4:141,793,612...141,815,978
Ensembl chr 4:141,793,612...141,815,976
JBrowse link
G Cat catalase decreases expression
multiple interactions
decreases activity
ISO
EXP
Fructose results in decreased expression of CAT mRNA; Fructose results in decreased expression of CAT protein
[Fructose co-treated with Dietary Fats] results in decreased activity of CAT protein; troxerutin inhibits the reaction [[Fructose co-treated with Dietary Fats] results in decreased activity of CAT protein]
[Hydrochlorothiazide co-treated with Fructose] results in decreased activity of CAT protein; APLN protein modified form inhibits the reaction [Fructose results in decreased activity of CAT protein]
CTD PMID:11817707 PMID:20470786 PMID:23707192 PMID:28916335 PMID:30710622 NCBI chr 2:103,453,904...103,485,153
Ensembl chr 2:103,453,849...103,485,160
JBrowse link
G Cavin3 caveolae associated 3 multiple interactions ISO [Fructose co-treated with bisphenol A] results in increased expression of CAVIN3 protein CTD PMID:26930160 NCBI chr 7:105,480,616...105,482,197
Ensembl chr 7:105,480,083...105,482,300
JBrowse link
G Ccl2 chemokine (C-C motif) ligand 2 multiple interactions
increases expression
increases secretion
ISO
EXP
[Fructose co-treated with Uric Acid] results in increased secretion of CCL2 protein; acetovanillone inhibits the reaction [Fructose results in increased secretion of CCL2 protein]; Acetylcysteine inhibits the reaction [Fructose results in increased secretion of CCL2 protein]; Allopurinol inhibits the reaction [[Fructose co-treated with Uric Acid] results in increased secretion of CCL2 protein]; Allopurinol inhibits the reaction [Fructose results in increased secretion of CCL2 protein]; Glucose inhibits the reaction [Fructose results in increased secretion of CCL2 protein]; KHK protein promotes the reaction [Fructose results in increased secretion of CCL2 protein]; Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin inhibits the reaction [Fructose results in increased secretion of CCL2 protein]; Superoxides affects the reaction [Fructose results in increased secretion of CCL2 protein]
Fructose results in increased expression of CCL2 protein
Fructose results in increased expression of CCL2 mRNA
[Dietary Fats co-treated with Fructose] results in increased expression of CCL2 protein; [FGF21 gene mutant form results in increased susceptibility to Fructose] which results in increased expression of CCL2 mRNA; [Fructose co-treated with Ethanol] results in increased expression of CCL2 mRNA; sarpogrelate inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of CCL2 protein]
[Copper deficiency co-treated with Fructose] results in increased expression of CCL2 protein; [Fructose co-treated with Copper deficiency] results in increased expression of CCL2 protein; [Lipopolysaccharides co-treated with Fructose co-treated with Copper deficiency] results in increased expression of CCL2 protein; [Particulate Matter co-treated with Ozone] promotes the reaction [Fructose results in increased expression of CCL2 mRNA]; [Streptozocin co-treated with Fructose] results in increased expression of and results in increased secretion of CCL2 protein; Acarbose inhibits the reaction [Fructose results in increased expression of CCL2 mRNA]; Acarbose inhibits the reaction [Fructose results in increased expression of CCL2 protein]; dapagliflozin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of and results in increased secretion of CCL2 protein]; Deferiprone inhibits the reaction [[Lipopolysaccharides co-treated with Fructose co-treated with Copper deficiency] results in increased expression of CCL2 protein]; Deferoxamine inhibits the reaction [[Lipopolysaccharides co-treated with Fructose co-treated with Copper deficiency] results in increased expression of CCL2 protein]; Fish Oils inhibits the reaction [Fructose results in increased expression of CCL2 protein]; gadolinium chloride inhibits the reaction [[Fructose co-treated with Copper deficiency] results in increased expression of CCL2 protein]; Metformin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of and results in increased secretion of CCL2 protein]; Ozone promotes the reaction [Fructose results in increased expression of CCL2 mRNA]; Particulate Matter promotes the reaction [Fructose results in increased expression of CCL2 mRNA]
Fructose results in increased expression of CCL2 mRNA; Fructose results in increased expression of CCL2 protein
CTD PMID:15752949 PMID:17133782 PMID:19158351 PMID:21781943 PMID:23968387 PMID:25813056 PMID:26824242 PMID:26858005 PMID:28123933 PMID:30551545 PMID:31655124 PMID:31672515 NCBI chr11:82,035,577...82,037,452
Ensembl chr11:82,035,571...82,037,453
JBrowse link
G Ccl3 chemokine (C-C motif) ligand 3 multiple interactions EXP [FGF21 gene mutant form results in increased susceptibility to Fructose] which results in increased expression of CCL3 mRNA CTD PMID:28123933 NCBI chr11:83,647,843...83,649,378
Ensembl chr11:83,647,844...83,649,355
JBrowse link
G Ccn2 cellular communication network factor 2 multiple interactions
increases expression
ISO betanin inhibits the reaction [Fructose results in increased expression of CCN2 protein] CTD PMID:25559852 NCBI chr10:24,595,442...24,598,683
Ensembl chr10:24,595,442...24,598,683
JBrowse link
G Cd163 CD163 antigen multiple interactions ISO
EXP
[gadolinium chloride co-treated with Fructose co-treated with Copper deficiency] results in decreased expression of CD163 mRNA
[Fructose co-treated with Ethanol] results in increased expression of CD163 mRNA
CTD PMID:25813056 PMID:26858005 NCBI chr 6:124,304,636...124,330,529
Ensembl chr 6:124,304,656...124,330,527
JBrowse link
G Cd36 CD36 molecule decreases expression
multiple interactions
EXP
ISO
Fructose results in decreased expression of CD36 protein
[Atorvastatin co-treated with dapagliflozin] inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of CD36 protein]; [Fructose co-treated with Dietary Fats] results in increased expression of CD36 protein; dapagliflozin inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of CD36 protein]
CTD PMID:28257781 PMID:32259528 NCBI chr 5:17,781,690...17,888,959
Ensembl chr 5:17,781,690...17,888,801
JBrowse link
G Cd68 CD68 antigen multiple interactions ISO
EXP
[Dietary Fats co-treated with Fructose] results in increased expression of CD68 mRNA; [gadolinium chloride co-treated with Fructose co-treated with Copper deficiency] results in decreased expression of CD68 mRNA; [gadolinium chloride co-treated with Fructose co-treated with Copper deficiency] results in decreased expression of CD68 protein
[FGF21 gene mutant form results in increased susceptibility to Fructose] which results in increased expression of CD68 mRNA; [Fructose co-treated with Ethanol] results in increased expression of CD68 mRNA
CTD PMID:19632207 PMID:25813056 PMID:26858005 PMID:28123933 NCBI chr11:69,664,213...69,666,170
Ensembl chr11:69,664,213...69,666,153
JBrowse link
G Chrm2 cholinergic receptor, muscarinic 2, cardiac increases expression ISO Fructose results in increased expression of CHRM2 mRNA; Fructose results in increased expression of CHRM2 protein CTD PMID:17707055 NCBI chr 6:36,387,991...36,528,638
Ensembl chr 6:36,388,084...36,528,414
JBrowse link
G Chrm3 cholinergic receptor, muscarinic 3, cardiac increases expression ISO Fructose results in increased expression of CHRM3 mRNA; Fructose results in increased expression of CHRM3 protein CTD PMID:17707055 NCBI chr13:9,875,486...10,361,062
Ensembl chr13:9,875,486...10,360,847
JBrowse link
G Chuk conserved helix-loop-helix ubiquitous kinase increases phosphorylation
multiple interactions
ISO Fructose results in increased phosphorylation of CHUK protein
Quercetin inhibits the reaction [Fructose results in increased phosphorylation of CHUK protein]
CTD PMID:24491314 NCBI chr19:44,073,334...44,107,505
Ensembl chr19:44,073,335...44,107,480
JBrowse link
G Cidea cell death-inducing DNA fragmentation factor, alpha subunit-like effector A decreases expression
multiple interactions
ISO Fructose results in decreased expression of CIDEA mRNA
[Ozone co-treated with Fructose] results in decreased expression of CIDEA mRNA; [Particulate Matter co-treated with Fructose] results in decreased expression of CIDEA mRNA; [Particulate Matter co-treated with Ozone co-treated with Fructose] results in decreased expression of CIDEA mRNA
CTD PMID:23968387 NCBI chr18:67,343,564...67,367,794
Ensembl chr18:67,343,604...67,367,785
JBrowse link
G Cnr1 cannabinoid receptor 1 (brain) increases expression
multiple interactions
ISO Fructose results in increased expression of CNR1 mRNA
[Fructose co-treated with Streptozocin] results in decreased expression of CNR1 mRNA; Ghrelin inhibits the reaction [[Fructose co-treated with Streptozocin] results in decreased expression of CNR1 mRNA]
CTD PMID:18627777 PMID:31468622 NCBI chr 4:33,923,171...33,948,831
Ensembl chr 4:33,924,593...33,948,831
JBrowse link
G Coq9 coenzyme Q9 multiple interactions ISO [Fructose co-treated with bisphenol A] results in increased expression of COQ9 protein CTD PMID:26930160 NCBI chr 8:94,838,413...94,854,895
Ensembl chr 8:94,838,321...94,854,895
JBrowse link
G Cp ceruloplasmin multiple interactions ISO [Fructose co-treated with Copper deficiency] results in decreased activity of CP protein; Fructose promotes the reaction [Copper deficiency results in decreased expression of CP protein] CTD PMID:21781943 PMID:25813056 NCBI chr 3:19,956,933...20,009,750
Ensembl chr 3:19,957,054...20,009,145
JBrowse link
G Cpt1a carnitine palmitoyltransferase 1a, liver multiple interactions ISO [Dietary Fats co-treated with Fructose] results in increased expression of CPT1A mRNA; [Fructose co-treated with Copper deficiency] results in decreased expression of CPT1A mRNA; [Fructose co-treated with Dietary Fats] results in decreased expression of CPT1A protein CTD PMID:19632207 PMID:25813056 PMID:32259528 NCBI chr19:3,322,326...3,385,735
Ensembl chr19:3,322,334...3,385,733
JBrowse link
G Creb1 cAMP responsive element binding protein 1 increases expression
multiple interactions
ISO Fructose results in increased expression of CREB1 mRNA; Fructose results in increased expression of CREB1 protein
rosiglitazone inhibits the reaction [Fructose results in increased expression of CREB1 mRNA]; rosiglitazone inhibits the reaction [Fructose results in increased expression of CREB1 protein]
CTD PMID:19196556 NCBI chr 1:64,532,794...64,604,548
Ensembl chr 1:64,532,645...64,604,548
JBrowse link
G Crp C-reactive protein, pentraxin-related multiple interactions
increases expression
ISO
EXP
[Dietary Fats co-treated with Fructose] results in increased expression of CRP mRNA; Curcumin inhibits the reaction [Fructose results in increased expression of CRP protein]; Metformin inhibits the reaction [Fructose results in increased expression of CRP protein]; resveratrol inhibits the reaction [Fructose results in increased expression of CRP protein] CTD PMID:19632207 PMID:25108154 PMID:26713546 PMID:31672515 NCBI chr 1:172,698,056...172,699,966
Ensembl chr 1:172,698,055...172,833,031
JBrowse link
G Cst3 cystatin C multiple interactions ISO [Streptozocin co-treated with Fructose] results in increased expression of CST3 protein; Metformin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of CST3 protein] CTD PMID:30551545 NCBI chr 2:148,871,722...148,875,512
Ensembl chr 2:148,871,722...148,875,692
JBrowse link
G Cx3cl1 chemokine (C-X3-C motif) ligand 1 increases expression ISO Fructose results in increased expression of CX3CL1 mRNA CTD PMID:31655124 NCBI chr 8:94,772,180...94,782,427
Ensembl chr 8:94,772,009...94,782,427
JBrowse link
G Cybb cytochrome b-245, beta polypeptide multiple interactions ISO [Dietary Fats co-treated with Fructose] results in increased expression of CYBB mRNA CTD PMID:19632207 NCBI chr  X:9,435,252...9,487,766
Ensembl chr  X:9,435,252...9,487,771
JBrowse link
G Cycs cytochrome c, somatic multiple interactions ISO [Atorvastatin co-treated with dapagliflozin] inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of CYCS protein]; [Fructose co-treated with Dietary Fats] results in increased expression of CYCS protein
[Fructose co-treated with Palmitic Acid] results in increased expression of CYCS protein; Fenofibrate inhibits the reaction [[Fructose co-treated with Palmitic Acid] results in increased expression of CYCS protein]
CTD PMID:32259528 PMID:32730863 NCBI chr 6:50,562,563...50,566,569
Ensembl chr 6:50,562,563...50,566,538
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions EXP [Dietary Fats co-treated with Fructose] results in increased expression of CYP1A1 mRNA CTD PMID:26102010 PMID:29416063 NCBI chr 9:57,687,928...57,703,824
Ensembl chr 9:57,687,928...57,703,824
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions EXP [Dietary Fats co-treated with Fructose] results in increased expression of CYP1A2 mRNA; alpha-Tocopherol inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of CYP1A2 mRNA]; tetrahydrocurcumin inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of CYP1A2 mRNA] CTD PMID:26102010 NCBI chr 9:57,676,937...57,683,655
Ensembl chr 9:57,676,937...57,683,703
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 multiple interactions EXP [Dietary Fats co-treated with Fructose] results in increased expression of CYP1B1 mRNA; [Dietary Fats co-treated with Fructose] results in increased expression of CYP1B1 protein; tetrahydrocurcumin inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of CYP1B1 mRNA]; tetrahydrocurcumin inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of CYP1B1 protein] CTD PMID:26102010 NCBI chr17:79,706,940...79,715,061
Ensembl chr17:79,701,537...79,715,061
JBrowse link
G Cyp2c29 cytochrome P450, family 2, subfamily c, polypeptide 29 multiple interactions EXP [Dietary Fats co-treated with Fructose] results in increased expression of CYP2C29 mRNA; [Dietary Fats co-treated with Fructose] results in increased expression of CYP2C29 protein; alpha-Tocopherol inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of CYP2C29 protein]; tetrahydrocurcumin inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of CYP2C29 mRNA]; tetrahydrocurcumin inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of CYP2C29 protein] CTD PMID:26102010 NCBI chr19:39,287,044...39,330,713
Ensembl chr19:39,269,405...39,330,713
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 decreases expression
multiple interactions
increases expression
EXP Fructose results in decreased expression of CYP2E1 protein
Ethanol promotes the reaction [Fructose results in increased expression of CYP2E1 protein]
CTD PMID:26858005 PMID:28257781 NCBI chr 7:140,763,819...140,774,990
Ensembl chr 7:140,763,739...140,774,987
JBrowse link
G Cyp3a11 cytochrome P450, family 3, subfamily a, polypeptide 11 multiple interactions EXP [Dietary Fats co-treated with Fructose] results in increased expression of CYP3A11 mRNA; alpha-Tocopherol inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of CYP3A11 mRNA]; tetrahydrocurcumin inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of CYP3A11 mRNA] CTD PMID:26102010 NCBI chr 5:145,854,607...145,879,854
Ensembl chr 5:145,854,426...145,879,964
JBrowse link
G Cyp4a12b cytochrome P450, family 4, subfamily a, polypeptide 12B multiple interactions ISO [Fructose co-treated with Copper deficiency] results in decreased expression of CYP4A1 mRNA; gadolinium chloride promotes the reaction [[Fructose co-treated with Copper deficiency] results in decreased expression of CYP4A1 mRNA] CTD PMID:25813056 NCBI chr 4:115,411,624...115,439,034
Ensembl chr 4:115,411,624...115,439,034
JBrowse link
G Cyp4a14 cytochrome P450, family 4, subfamily a, polypeptide 14 increases expression EXP Fructose results in increased expression of CYP4A14 mRNA CTD PMID:22698815 NCBI chr 4:115,486,200...115,496,158
Ensembl chr 4:115,486,200...115,496,142
JBrowse link
G Ddt D-dopachrome tautomerase decreases expression
multiple interactions
ISO Fructose results in decreased expression of DDT protein
[Fructose co-treated with bisphenol A] results in increased expression of DDT protein
CTD PMID:26930160 NCBI chr10:75,771,233...75,773,374
Ensembl chr10:75,771,230...75,773,414
JBrowse link
G Dek DEK proto-oncogene (DNA binding) multiple interactions ISO DEK protein results in decreased chemical synthesis of and results in decreased secretion of Fructose CTD PMID:28558019 NCBI chr13:47,084,767...47,107,530
Ensembl chr13:47,084,775...47,106,201
JBrowse link
G Dgat1 diacylglycerol O-acyltransferase 1 multiple interactions EXP [FGF21 gene mutant form results in increased susceptibility to Fructose] which results in increased expression of DGAT1 mRNA CTD PMID:28123933 NCBI chr15:76,502,012...76,512,021
Ensembl chr15:76,502,015...76,511,953
JBrowse link
G Dgat2 diacylglycerol O-acyltransferase 2 multiple interactions EXP [FGF21 gene mutant form results in increased susceptibility to Fructose] which results in decreased expression of DGAT2 mRNA CTD PMID:28123933 NCBI chr 7:99,153,663...99,182,713
Ensembl chr 7:99,153,658...99,182,719
JBrowse link
G Dld dihydrolipoamide dehydrogenase multiple interactions ISO [Fructose co-treated with bisphenol A] results in decreased expression of DLD protein CTD PMID:26930160 NCBI chr12:31,331,562...31,351,471
Ensembl chr12:31,331,277...31,351,453
JBrowse link
G Dnm1l dynamin 1-like multiple interactions ISO [Fructose co-treated with Palmitic Acid] results in increased expression of DNM1L protein; Fenofibrate inhibits the reaction [[Fructose co-treated with Palmitic Acid] results in increased expression of DNM1L protein] CTD PMID:32730863 NCBI chr16:16,312,228...16,359,038
Ensembl chr16:16,312,230...16,358,959
JBrowse link
G Dpt dermatopontin multiple interactions
decreases expression
ISO [Ozone co-treated with Fructose] results in decreased expression of DPT mRNA; [Particulate Matter co-treated with Fructose] results in decreased expression of DPT mRNA; Fructose affects the reaction [[Ozone co-treated with Particulate Matter] results in decreased expression of DPT mRNA]
Fructose results in decreased expression of DPT mRNA
CTD PMID:23968387 NCBI chr 1:164,796,663...164,824,274
Ensembl chr 1:164,796,644...164,824,266
JBrowse link
G Echs1 enoyl Coenzyme A hydratase, short chain, 1, mitochondrial multiple interactions ISO [Fructose co-treated with bisphenol A] results in increased expression of ECHS1 protein CTD PMID:26930160 NCBI chr 7:140,105,710...140,116,421
Ensembl chr 7:140,105,710...140,116,476
JBrowse link
G Edn1 endothelin 1 increases response to substance
increases expression
multiple interactions
ISO Fructose results in increased susceptibility to EDN1 protein
Fructose results in increased expression of EDN1 mRNA; Fructose results in increased expression of EDN1 protein modified form
KLK1 protein inhibits the reaction [Fructose results in increased expression of EDN1 mRNA]; Metformin inhibits the reaction [Fructose results in increased expression of EDN1 protein]; resveratrol inhibits the reaction [Fructose results in increased expression of EDN1 protein]
CTD PMID:9869011 PMID:11172478 PMID:14568997 PMID:25108154 NCBI chr13:42,301,476...42,307,990
Ensembl chr13:42,301,476...42,307,990
JBrowse link
G Ednra endothelin receptor type A multiple interactions
increases expression
ISO KLK1 protein inhibits the reaction [Fructose results in increased expression of EDNRA mRNA] CTD PMID:9869011 PMID:14568997 PMID:31655124 NCBI chr 8:77,663,029...77,724,452
Ensembl chr 8:77,663,031...77,724,464
JBrowse link
G Eef1a2 eukaryotic translation elongation factor 1 alpha 2 multiple interactions ISO [Fructose co-treated with bisphenol A] results in decreased expression of EEF1A2 protein CTD PMID:26930160 NCBI chr 2:181,141,758...181,157,015
Ensembl chr 2:181,147,653...181,157,014
JBrowse link
G Egf epidermal growth factor increases uptake
multiple interactions
ISO EGF protein results in increased uptake of Fructose
wortmannin inhibits the reaction [EGF protein results in increased uptake of Fructose]
CTD PMID:15691865 NCBI chr 3:129,677,574...129,755,322
Ensembl chr 3:129,677,565...129,755,316
JBrowse link
G Eif2ak2 eukaryotic translation initiation factor 2-alpha kinase 2 increases expression
multiple interactions
ISO Fructose results in increased expression of EIF2AK2 protein
imoxin inhibits the reaction [Fructose results in increased expression of EIF2AK2 protein]
CTD PMID:29430716 NCBI chr17:78,850,504...78,882,572
Ensembl chr17:78,852,564...78,882,573
JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 increases phosphorylation
multiple interactions
EXP Fructose results in increased phosphorylation of EIF2AK3 protein
Phenylbutyrates inhibits the reaction [Fructose results in increased phosphorylation of EIF2AK3 protein]
CTD PMID:22698815 NCBI chr 6:70,844,484...70,905,241
Ensembl chr 6:70,844,515...70,905,245
JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2, subunit 1 alpha increases phosphorylation
multiple interactions
EXP Fructose results in increased phosphorylation of EIF2S1 protein
Phenylbutyrates inhibits the reaction [Fructose results in increased phosphorylation of EIF2S1 protein]
CTD PMID:22698815 NCBI chr12:78,862,072...78,887,010
Ensembl chr12:78,861,819...78,887,010
JBrowse link
G Elovl6 ELOVL family member 6, elongation of long chain fatty acids (yeast) increases expression EXP Fructose results in increased expression of ELOVL6 mRNA CTD PMID:15066988 NCBI chr 3:129,532,386...129,638,495
Ensembl chr 3:129,532,355...129,638,495
JBrowse link
G Entpd2 ectonucleoside triphosphate diphosphohydrolase 2 decreases expression ISO Fructose results in decreased expression of ENTPD2 mRNA CTD PMID:15150374 NCBI chr 2:25,395,874...25,401,323
Ensembl chr 2:25,395,874...25,401,321
JBrowse link
G Ezr ezrin multiple interactions ISO [Fructose co-treated with bisphenol A] results in increased expression of EZR protein CTD PMID:26930160 NCBI chr17:6,738,131...6,782,780
Ensembl chr17:6,738,041...6,782,784
JBrowse link
G F3 coagulation factor III increases expression ISO Fructose results in increased expression of F3 mRNA CTD PMID:31655124 NCBI chr 3:121,723,537...121,735,052
Ensembl chr 3:121,723,537...121,735,048
JBrowse link
G Fabp3 fatty acid binding protein 3, muscle and heart multiple interactions ISO [Fructose co-treated with bisphenol A] results in increased expression of FABP3 protein CTD PMID:26930160 NCBI chr 4:130,308,738...130,315,463
Ensembl chr 4:130,308,595...130,315,463
JBrowse link
G Fabp4 fatty acid binding protein 4, adipocyte multiple interactions ISO [Fructose co-treated with bisphenol A] results in increased expression of FABP4 protein CTD PMID:26930160 NCBI chr 3:10,204,342...10,208,616
Ensembl chr 3:10,204,088...10,208,576
JBrowse link
G Fas Fas (TNF receptor superfamily member 6) decreases expression ISO Fructose results in decreased expression of FAS mRNA CTD PMID:31655124 NCBI chr19:34,290,647...34,327,775
Ensembl chr19:34,290,666...34,327,772
JBrowse link
G Fasl Fas ligand (TNF superfamily, member 6) increases expression ISO Fructose results in increased expression of FASLG mRNA CTD PMID:31655124 NCBI chr 1:161,780,691...161,788,495
Ensembl chr 1:161,780,689...161,788,495
JBrowse link
G Fasn fatty acid synthase increases expression
multiple interactions
increases activity
EXP
ISO
Fructose results in increased expression of FASN mRNA; Fructose results in increased expression of FASN protein
[Fructose co-treated with Palmitic Acid] results in increased expression of FASN protein; Fenofibrate inhibits the reaction [[Fructose co-treated with Palmitic Acid] results in increased expression of FASN protein]
[Atorvastatin co-treated with dapagliflozin] inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of FASN protein]; [Copper deficiency co-treated with Fructose] results in increased expression of FASN protein; [Fenofibrate co-treated with Resveratrol] inhibits the reaction [Fructose results in increased expression of FASN mRNA]; [Fructose co-treated with Dietary Fats] results in increased expression of FASN protein; [gadolinium chloride co-treated with Fructose co-treated with Copper deficiency] results in decreased expression of FASN mRNA; Atorvastatin inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of FASN protein]; dapagliflozin inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of FASN protein]; Fenofibrate inhibits the reaction [Fructose results in increased expression of FASN mRNA]; Resveratrol inhibits the reaction [Fructose results in increased expression of FASN mRNA]; Rosiglitazone inhibits the reaction [Fructose results in increased expression of FASN mRNA]; Tea inhibits the reaction [Fructose results in increased expression of FASN mRNA]
Fructose results in increased activity of FASN protein
FGF21 gene mutant form inhibits the reaction [Fructose results in increased expression of FASN mRNA]; Phenylbutyrates inhibits the reaction [Fructose results in increased expression of FASN mRNA]; Plant Preparations inhibits the reaction [Fructose results in increased expression of FASN protein]; SCD1 gene mutant form inhibits the reaction [Fructose results in increased expression of FASN mRNA]; Triolein inhibits the reaction [SCD1 gene mutant form inhibits the reaction [Fructose results in increased expression of FASN mRNA]]; Triolein promotes the reaction [Fructose results in increased expression of FASN mRNA]
CTD PMID:8759368 PMID:9566986 PMID:12065722 PMID:15066988 PMID:18346472 PMID:19053045 PMID:19193814 PMID:19196556 PMID:21781943 PMID:22698815 PMID:25813056 PMID:26973390 PMID:27531227 PMID:28123933 PMID:28257781 PMID:32259528 PMID:32730863 NCBI chr11:120,805,958...120,825,166
Ensembl chr11:120,805,846...120,824,547
JBrowse link
G Fbp1 fructose bisphosphatase 1 increases activity
increases expression
multiple interactions
ISO Fructose results in increased activity of FBP1 protein
Fructose results in increased expression of FBP1 mRNA
Vanadates inhibits the reaction [Fructose results in increased activity of FBP1 protein]
CTD PMID:15150374 PMID:16920846 PMID:18346472 NCBI chr13:62,864,753...62,888,298
Ensembl chr13:62,864,753...62,888,282
JBrowse link
G Fgf21 fibroblast growth factor 21 increases expression
multiple interactions
increases response to substance
increases secretion
EXP Fructose results in increased expression of FGF21 mRNA
[FGF21 gene mutant form results in increased susceptibility to Fructose] which results in decreased abundance of Blood Glucose; [FGF21 gene mutant form results in increased susceptibility to Fructose] which results in decreased expression of APOB mRNA; [FGF21 gene mutant form results in increased susceptibility to Fructose] which results in decreased expression of DGAT2 mRNA; [FGF21 gene mutant form results in increased susceptibility to Fructose] which results in increased expression of CCL2 mRNA; [FGF21 gene mutant form results in increased susceptibility to Fructose] which results in increased expression of CCL3 mRNA; [FGF21 gene mutant form results in increased susceptibility to Fructose] which results in increased expression of CD68 mRNA; [FGF21 gene mutant form results in increased susceptibility to Fructose] which results in increased expression of DGAT1 mRNA; [FGF21 gene mutant form results in increased susceptibility to Fructose] which results in increased expression of MMP2 mRNA; [FGF21 gene mutant form results in increased susceptibility to Fructose] which results in increased expression of TGFB1 mRNA; [FGF21 gene mutant form results in increased susceptibility to Fructose] which results in increased expression of TGFB2 mRNA; FGF21 gene mutant form inhibits the reaction [Fructose results in increased expression of ACACA mRNA]; FGF21 gene mutant form inhibits the reaction [Fructose results in increased expression of ACACB mRNA]; FGF21 gene mutant form inhibits the reaction [Fructose results in increased expression of ALDOB mRNA]; FGF21 gene mutant form inhibits the reaction [Fructose results in increased expression of FASN mRNA]; FGF21 gene mutant form inhibits the reaction [Fructose results in increased expression of KHK mRNA]; FGF21 gene mutant form inhibits the reaction [Fructose results in increased expression of MLXIPL mRNA alternative form]; FGF21 gene mutant form inhibits the reaction [Fructose results in increased expression of MTTP mRNA]; FGF21 gene mutant form inhibits the reaction [Fructose results in increased expression of PKLR mRNA]; FGF21 gene mutant form inhibits the reaction [Fructose results in increased expression of SCD1 mRNA]; FGF21 gene mutant form inhibits the reaction [Fructose results in increased secretion of very low density lipoprotein triglyceride]; MLXIPL gene mutant form inhibits the reaction [Fructose results in increased expression of FGF21 mRNA]; MLXIPL gene mutant form inhibits the reaction [Fructose results in increased secretion of FGF21 protein]
CTD PMID:28123933 NCBI chr 7:45,613,890...45,615,490
Ensembl chr 7:45,613,886...45,615,490
JBrowse link
G Fhl2 four and a half LIM domains 2 multiple interactions ISO [Fructose co-treated with bisphenol A] results in decreased expression of FHL2 protein CTD PMID:26930160 NCBI chr 1:43,123,071...43,198,343
Ensembl chr 1:43,123,074...43,196,984
JBrowse link
G Fis1 fission, mitochondrial 1 multiple interactions ISO [Fructose co-treated with Palmitic Acid] results in increased expression of FIS1 protein; Fenofibrate inhibits the reaction [[Fructose co-treated with Palmitic Acid] results in increased expression of FIS1 protein] CTD PMID:32730863 NCBI chr 5:136,953,275...136,966,234
Ensembl chr 5:136,953,275...136,966,234
JBrowse link
G Fos FBJ osteosarcoma oncogene multiple interactions
increases expression
ISO Dactinomycin inhibits the reaction [Fructose results in increased expression of FOS mRNA] CTD PMID:11123204 PMID:11557636 NCBI chr12:85,473,890...85,477,274
Ensembl chr12:85,473,890...85,477,273
JBrowse link
G Foxo1 forkhead box O1 multiple interactions
increases expression
ISO Fructose results in increased expression of and affects the localization of FOXO1 protein; Fructose results in increased expression of and results in increased phosphorylation of FOXO1 protein; Quercetin inhibits the reaction [Fructose results in increased expression of and affects the localization of FOXO1 protein]; Quercetin inhibits the reaction [Fructose results in increased expression of and results in increased phosphorylation of FOXO1 protein]; rosiglitazone inhibits the reaction [Fructose results in increased expression of FOXO1 mRNA] CTD PMID:19196556 PMID:23533474 NCBI chr 3:52,268,337...52,350,109
Ensembl chr 3:52,268,336...52,353,221
JBrowse link
G Fth1 ferritin heavy polypeptide 1 increases expression ISO Fructose results in increased expression of FTH1 protein CTD PMID:26930160 NCBI chr19:9,980,600...9,985,111
Ensembl chr19:9,980,598...9,985,098
JBrowse link
G G6pc glucose-6-phosphatase, catalytic multiple interactions
increases expression
ISO Rosiglitazone inhibits the reaction [Fructose results in increased expression of G6PC1 mRNA]; Rosiglitazone inhibits the reaction [Fructose results in increased expression of G6PC1 protein]
Fructose results in increased expression of G6PC1 mRNA; Fructose results in increased expression of G6PC1 protein
CTD PMID:14988444 PMID:15150374 PMID:16920846 PMID:18346472 PMID:18556366 PMID:19196556 NCBI chr11:101,367,716...101,377,903
Ensembl chr11:101,367,561...101,377,903
JBrowse link
G G6pdx glucose-6-phosphate dehydrogenase X-linked increases activity
multiple interactions
decreases expression
ISO Fructose results in increased activity of G6PD protein
Glutamine inhibits the reaction [Fructose results in decreased expression of G6PD protein]
CTD PMID:18346472 PMID:31233715 NCBI chr  X:74,409,483...74,428,880
Ensembl chr  X:74,409,483...74,429,194
JBrowse link
G Gcg glucagon multiple interactions ISO GCG protein affects the reaction [Fructose affects the degradation of PKLR mRNA] CTD PMID:2414297 NCBI chr 2:62,474,530...62,483,653
Ensembl chr 2:62,474,530...62,483,650
JBrowse link
G Gck glucokinase increases activity ISO Fructose results in increased activity of GCK protein CTD PMID:20470786 NCBI chr11:5,900,816...5,950,081
Ensembl chr11:5,900,820...5,950,081
JBrowse link
G Gckr glucokinase regulatory protein increases expression ISO Fructose results in increased expression of GCKR mRNA CTD PMID:18346472 NCBI chr 5:31,297,266...31,327,302
Ensembl chr 5:31,297,443...31,327,314
JBrowse link
G Ghrl ghrelin increases expression ISO Fructose results in increased expression of GHRL protein CTD PMID:18627777 NCBI chr 6:113,716,119...113,719,911
Ensembl chr 6:113,716,119...113,719,880
JBrowse link
G Glp1r glucagon-like peptide 1 receptor multiple interactions ISO [Fructose co-treated with Streptozocin] results in decreased expression of GLP1R mRNA; Ghrelin inhibits the reaction [[Fructose co-treated with Streptozocin] results in decreased expression of GLP1R mRNA] CTD PMID:31468622 NCBI chr17:30,901,867...30,936,510
Ensembl chr17:30,901,817...30,940,791
JBrowse link
G Glul glutamate-ammonia ligase (glutamine synthetase) decreases expression
multiple interactions
ISO Fructose results in decreased expression of GLUL protein
Allopurinol inhibits the reaction [Fructose results in decreased expression of GLUL protein]; Quercetin inhibits the reaction [Fructose results in decreased expression of GLUL protein]
CTD PMID:24491314 NCBI chr 1:153,899,929...153,909,723
Ensembl chr 1:153,899,944...153,909,723
JBrowse link
G Gnat3 guanine nucleotide binding protein, alpha transducing 3 affects response to substance EXP GNAT3 protein affects the susceptibility to Fructose CTD PMID:16740645 NCBI chr 5:17,962,570...18,019,668
Ensembl chr 5:17,962,549...18,019,834
JBrowse link
G Gnmt glycine N-methyltransferase multiple interactions EXP [Dietary Fats co-treated with Fructose] results in increased expression of GNMT mRNA CTD PMID:29416063 NCBI chr17:46,725,664...46,729,211
Ensembl chr17:46,725,664...46,729,168
JBrowse link
G Gpam glycerol-3-phosphate acyltransferase, mitochondrial multiple interactions
increases expression
ISO [Folic Acid affects the susceptibility to Fructose] which affects the expression of GPAM mRNA; Atorvastatin inhibits the reaction [Fructose results in increased expression of GPAM mRNA] CTD PMID:18346472 PMID:19053045 PMID:31612177 NCBI chr19:55,067,635...55,127,319
Ensembl chr19:55,067,268...55,127,238
JBrowse link
G Gpld1 glycosylphosphatidylinositol specific phospholipase D1 increases expression EXP Fructose results in increased expression of GPLD1 protein CTD PMID:16219662 NCBI chr13:24,937,785...24,991,936
Ensembl chr13:24,943,152...24,992,501
JBrowse link
G Gpt glutamic pyruvic transaminase, soluble increases activity
multiple interactions
EXP
ISO
Fructose results in increased activity of GPT protein
[dapagliflozin co-treated with Atorvastatin] inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of GPT protein]; [Fructose co-treated with Dietary Fats] results in increased expression of GPT protein; Atorvastatin inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of GPT protein]; dapagliflozin inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of GPT protein]
[Fructose co-treated with Ethanol] results in increased expression of GPT protein; Plant Preparations inhibits the reaction [Fructose results in increased activity of GPT protein]
CTD PMID:26858005 PMID:27531227 PMID:32259528 NCBI chr15:76,696,726...76,699,675
Ensembl chr15:76,695,716...76,699,686
JBrowse link
G Gpx1 glutathione peroxidase 1 decreases expression ISO Fructose results in decreased expression of GPX1 mRNA CTD PMID:16815490 PMID:20470786 NCBI chr 9:108,339,080...108,340,342
Ensembl chr 9:108,338,903...108,340,343
JBrowse link
G Gpx4 glutathione peroxidase 4 decreases expression ISO Fructose results in decreased expression of GPX4 protein CTD PMID:21781943 NCBI chr10:80,047,166...80,056,439
Ensembl chr10:80,047,166...80,056,439
JBrowse link
G Gsr glutathione reductase increases activity ISO Fructose results in increased activity of GSR protein CTD PMID:17710547 NCBI chr 8:33,653,238...33,698,162
Ensembl chr 8:33,652,523...33,698,163
JBrowse link
G Hamp hepcidin antimicrobial peptide multiple interactions ISO [Fructose co-treated with Copper deficiency] results in decreased expression of HAMP protein CTD PMID:25813056 NCBI chr 7:30,942,368...30,944,029
Ensembl chr 7:30,942,368...30,944,032
JBrowse link
G Havcr1 hepatitis A virus cellular receptor 1 multiple interactions ISO [Streptozocin co-treated with Fructose] results in increased expression of HAVCR1 protein; dapagliflozin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of HAVCR1 protein]; dapagliflozin promotes the reaction [Metformin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of HAVCR1 protein]]; Metformin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of HAVCR1 protein]; Metformin promotes the reaction [dapagliflozin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of HAVCR1 protein]] CTD PMID:30551545 NCBI chr11:46,739,822...46,779,578
Ensembl chr11:46,735,080...46,779,578
JBrowse link
G Hbb-b1 hemoglobin, beta adult major chain multiple interactions ISO Fructose promotes the reaction [Glucose binds to HBB protein]; geraniol inhibits the reaction [Fructose promotes the reaction [Glucose binds to HBB protein]]; Pioglitazone inhibits the reaction [Fructose promotes the reaction [Glucose binds to HBB protein]] CTD PMID:25679220
G Hmgcr 3-hydroxy-3-methylglutaryl-Coenzyme A reductase multiple interactions
increases expression
ISO [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in decreased activity of SIRT1 protein] inhibits the reaction [Fructose results in increased expression of HMGCR mRNA]; [Niacinamide results in decreased activity of SIRT1 protein] inhibits the reaction [Fructose results in increased expression of HMGCR mRNA]; Rotenone inhibits the reaction [Fructose results in increased expression of HMGCR mRNA]; Tea inhibits the reaction [Fructose results in increased expression of HMGCR mRNA] CTD PMID:19193814 PMID:21212096 NCBI chr13:96,648,962...96,670,936
Ensembl chr13:96,648,967...96,670,936
JBrowse link
G Hmgcs2 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 multiple interactions ISO [Fructose co-treated with Copper deficiency] results in decreased expression of HMGCS2 mRNA; gadolinium chloride promotes the reaction [[Fructose co-treated with Copper deficiency] results in decreased expression of HMGCS2 mRNA] CTD PMID:25813056 NCBI chr 3:98,280,431...98,310,738
Ensembl chr 3:98,280,435...98,310,738
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression
ISO
EXP
[Atorvastatin co-treated with dapagliflozin] inhibits the reaction [[Fructose co-treated with Dietary Fats] results in decreased expression of HMOX1 protein]; [Curcumin co-treated with Fructose] results in increased expression of HMOX1 protein; [Fructose co-treated with Dietary Fats] results in decreased expression of HMOX1 protein; [Hemin co-treated with Fructose] results in increased expression of HMOX1 protein; Atorvastatin inhibits the reaction [[Fructose co-treated with Dietary Fats] results in decreased expression of HMOX1 protein]; caffeic acid phenethyl ester inhibits the reaction [Fructose results in increased expression of HMOX1 protein]; dapagliflozin inhibits the reaction [[Fructose co-treated with Dietary Fats] results in decreased expression of HMOX1 protein]
Fructose results in increased expression of HMOX1 mRNA
CTD PMID:24508943 PMID:25268984 PMID:28257781 PMID:31655124 PMID:32259528 NCBI chr 8:75,093,618...75,100,593
Ensembl chr 8:75,093,621...75,100,589
JBrowse link
G Hnf4a hepatic nuclear factor 4, alpha multiple interactions
decreases expression
ISO Cerulenin inhibits the reaction [Fructose results in decreased expression of HNF4A mRNA]
Fructose results in decreased expression of HNF4A mRNA; Fructose results in decreased expression of HNF4A protein
Berberine inhibits the reaction [Fructose results in decreased expression of HNF4A mRNA]; Berberine inhibits the reaction [Fructose results in decreased expression of HNF4A protein]; rosiglitazone inhibits the reaction [Fructose results in decreased expression of HNF4A mRNA]
CTD PMID:17992261 PMID:18563319 PMID:19196556 NCBI chr 2:163,506,811...163,572,907
Ensembl chr 2:163,506,808...163,572,910
JBrowse link
G Hnrnpa2b1 heterogeneous nuclear ribonucleoprotein A2/B1 multiple interactions
decreases expression
ISO [Fructose co-treated with bisphenol A] results in increased expression of HNRNPA2B1 protein
Fructose results in decreased expression of HNRNPA2B1 protein
CTD PMID:26930160 NCBI chr 6:51,460,434...51,470,048
Ensembl chr 6:51,460,932...51,469,894
JBrowse link
G Hnrnpa3 heterogeneous nuclear ribonucleoprotein A3 multiple interactions ISO [Fructose co-treated with bisphenol A] results in increased expression of HNRNPA3 protein CTD PMID:26930160 NCBI chr 2:75,659,105...75,669,407
Ensembl chr 2:75,659,261...75,669,407
JBrowse link
G Hnrnpk heterogeneous nuclear ribonucleoprotein K multiple interactions ISO [Fructose co-treated with bisphenol A] results in increased expression of HNRNPK protein CTD PMID:26930160 NCBI chr13:58,391,132...58,403,343
Ensembl chr13:58,391,142...58,403,343
JBrowse link
G Hoxc9 homeobox C9 decreases expression
multiple interactions
ISO Fructose results in decreased expression of HOXC9 mRNA
[Ozone co-treated with Fructose] results in decreased expression of HOXC9 mRNA; [Particulate Matter co-treated with Ozone co-treated with Fructose] results in decreased expression of HOXC9 mRNA; Fructose affects the reaction [Particulate Matter results in decreased expression of HOXC9 mRNA]
CTD PMID:23968387 NCBI chr15:102,977,032...102,984,444
Ensembl chr15:102,976,439...102,985,099
JBrowse link
G Hprt hypoxanthine guanine phosphoribosyl transferase decreases expression ISO Fructose results in decreased expression of HPRT1 mRNA CTD PMID:31655124 NCBI chr  X:52,988,078...53,021,660
Ensembl chr  X:52,988,137...53,021,659
JBrowse link
G Hspa1b heat shock protein 1B increases expression ISO Fructose results in increased expression of HSPA1B mRNA CTD PMID:15150374 NCBI chr17:34,956,429...34,959,238
Ensembl chr17:34,956,436...34,959,238
JBrowse link
G Hspa5 heat shock protein 5 increases expression
multiple interactions
EXP Fructose results in increased expression of HSPA5 mRNA; Fructose results in increased expression of HSPA5 protein
Phenylbutyrates inhibits the reaction [Fructose results in increased expression of HSPA5 protein]
CTD PMID:22698815 NCBI chr 2:34,772,090...34,776,529
Ensembl chr 2:34,771,970...34,777,547
JBrowse link
G Hspd1 heat shock protein 1 (chaperonin) multiple interactions
increases expression
ISO Amlodipine inhibits the reaction [Fructose results in increased expression of HSPD1 protein]; rosiglitazone inhibits the reaction [Fructose results in increased expression of HSPD1 protein] CTD PMID:18948349 PMID:26930160 NCBI chr 1:55,077,833...55,088,243
Ensembl chr 1:55,077,835...55,088,243
JBrowse link
G Hspe1 heat shock protein 1 (chaperonin 10) multiple interactions ISO [Fructose co-treated with bisphenol A] results in increased expression of HSPE1 protein CTD PMID:26930160 NCBI chr 1:55,088,148...55,091,317
Ensembl chr 1:55,088,132...55,091,307
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions
increases expression
ISO 2,2'-(hydroxynitrosohydrazono)bis-ethanamine inhibits the reaction [Fructose results in increased expression of ICAM1 protein]; Adenosine Triphosphate inhibits the reaction [Fructose results in increased expression of ICAM1 protein]
Metformin inhibits the reaction [Fructose results in increased expression of ICAM1 protein modified form]; resveratrol inhibits the reaction [Fructose results in increased expression of ICAM1 protein modified form]
Fructose results in increased expression of ICAM1 mRNA; Fructose results in increased expression of ICAM1 protein
CTD PMID:18508964 PMID:25108154 NCBI chr 9:21,015,940...21,028,814
Ensembl chr 9:21,015,985...21,028,817
JBrowse link
G Idh3b isocitrate dehydrogenase 3 (NAD+) beta decreases expression ISO Fructose results in decreased expression of IDH3B protein CTD PMID:26930160 NCBI chr 2:130,279,309...130,284,451
Ensembl chr 2:130,279,309...130,284,547
JBrowse link
G Igfbp3 insulin-like growth factor binding protein 3 multiple interactions ISO [Fructose co-treated with Ozone co-treated with Particulate Matter] results in decreased expression of IGFBP3 mRNA; [Fructose co-treated with Ozone] results in decreased expression of IGFBP3 mRNA; [Particulate Matter co-treated with Fructose] results in decreased expression of IGFBP3 mRNA; Fructose affects the reaction [Particulate Matter results in decreased expression of IGFBP3 mRNA] CTD PMID:23968387 NCBI chr11:7,206,086...7,215,498
Ensembl chr11:7,206,086...7,213,923
JBrowse link
G Ikbkb inhibitor of kappaB kinase beta increases phosphorylation
multiple interactions
ISO Fructose results in increased phosphorylation of IKBKB protein
Allopurinol inhibits the reaction [Fructose results in increased phosphorylation of IKBKB protein]; Quercetin inhibits the reaction [Fructose results in increased phosphorylation of IKBKB protein]
CTD PMID:24491314 NCBI chr 8:22,659,205...22,706,589
Ensembl chr 8:22,659,212...22,706,589
JBrowse link
G Il10 interleukin 10 multiple interactions
decreases expression
ISO [Fructose co-treated with Ozone co-treated with Particulate Matter] results in decreased expression of IL10 mRNA; Fructose affects the reaction [Ozone results in decreased expression of IL10 mRNA]; Fructose affects the reaction [Particulate Matter results in decreased expression of IL10 mRNA]
Fructose results in decreased expression of IL10 mRNA
CTD PMID:23968387 NCBI chr 1:131,019,845...131,024,970
Ensembl chr 1:131,019,845...131,024,974
JBrowse link
G Il18 interleukin 18 multiple interactions
increases expression
ISO Allopurinol inhibits the reaction [Fructose results in increased expression of IL18 protein]; Felodipine inhibits the reaction [Fructose results in increased expression of IL18 mRNA]; Felodipine inhibits the reaction [Fructose results in increased expression of IL18 protein]; Quercetin inhibits the reaction [Fructose results in increased expression of IL18 protein]; Rutin inhibits the reaction [Fructose results in increased expression of IL18 protein]
Fructose results in increased expression of IL18 mRNA; Fructose results in increased expression of IL18 protein
CTD PMID:18504504 PMID:22426011 NCBI chr 9:50,554,700...50,581,841
Ensembl chr 9:50,554,827...50,581,840
JBrowse link
G Il1b interleukin 1 beta increases expression
increases secretion
multiple interactions
ISO
EXP
Fructose results in increased expression of IL1B protein
Fructose results in increased secretion of IL1B protein
[Fructose co-treated with Ethanol] results in increased expression of IL1B mRNA
[gadolinium chloride co-treated with Fructose co-treated with Copper deficiency] results in decreased expression of IL1B mRNA; Allopurinol inhibits the reaction [Fructose results in increased expression of IL1B protein]; geraniol inhibits the reaction [Fructose results in increased expression of IL1B protein]; geraniol inhibits the reaction [Fructose results in increased secretion of IL1B protein]; Pioglitazone inhibits the reaction [Fructose results in increased secretion of IL1B protein]; PTMA protein inhibits the reaction [Fructose results in increased expression of IL1B protein]; Quercetin inhibits the reaction [Fructose results in increased expression of IL1B protein]; Rutin inhibits the reaction [Fructose results in increased expression of IL1B protein]; tributylhexadecylphosphonium bromide inhibits the reaction [Fructose results in increased expression of IL1B protein]
CTD PMID:15885234 PMID:22426011 PMID:24491314 PMID:25679220 PMID:25813056 PMID:26358169 PMID:26858005 PMID:31005848 NCBI chr 2:129,364,569...129,371,164
Ensembl chr 2:129,364,570...129,371,139
JBrowse link
G Il2 interleukin 2 increases expression ISO Fructose results in increased expression of IL2 protein CTD PMID:15885234 NCBI chr 3:37,120,713...37,125,954
Ensembl chr 3:37,120,523...37,125,959
JBrowse link
G Il6 interleukin 6 multiple interactions
increases expression
ISO
EXP
[gadolinium chloride co-treated with Fructose co-treated with Copper deficiency] results in decreased expression of IL6 mRNA; Allopurinol inhibits the reaction [Fructose results in increased expression of IL6 protein]; galangin inhibits the reaction [Fructose results in increased expression of IL6 protein]; Genistein inhibits the reaction [Fructose results in increased expression of IL6 protein]; geraniol inhibits the reaction [Fructose results in increased expression of IL6 protein]; Metformin inhibits the reaction [Fructose results in increased expression of IL6 protein]; PTMA protein inhibits the reaction [Fructose results in increased expression of IL6 protein]; Quercetin inhibits the reaction [Fructose results in increased expression of IL6 protein]; Resveratrol inhibits the reaction [Fructose results in increased expression of IL6 protein]; Rutin inhibits the reaction [Fructose results in increased expression of IL6 protein]; tributylhexadecylphosphonium bromide inhibits the reaction [Fructose results in increased expression of IL6 protein] CTD PMID:15885234 PMID:21704028 PMID:21708140 PMID:22426011 PMID:25108154 PMID:25813056 PMID:26358169 PMID:27531227 PMID:31005848 PMID:31672515 NCBI chr 5:30,013,114...30,019,975
Ensembl chr 5:30,013,114...30,019,981
JBrowse link
G Ins1 insulin I increases secretion
multiple interactions
increases expression
EXP Fructose results in increased secretion of INS1 protein
Ethanol inhibits the reaction [Fructose results in increased expression of INS1 protein]; Fructose inhibits the reaction [Ethanol results in increased expression of INS1 protein]
CTD PMID:23533474 PMID:26858005 NCBI chr19:52,264,297...52,265,015
Ensembl chr19:52,264,297...52,265,476
JBrowse link
G Ins2 insulin II decreases response to substance
increases secretion
increases expression
multiple interactions
ISO Fructose results in decreased susceptibility to INS protein
Fructose results in increased secretion of INS protein
Fructose results in increased expression of INS protein; Fructose results in increased expression of INS2 mRNA
Curcumin inhibits the reaction [Fructose results in increased expression of INS protein]; Hemin inhibits the reaction [Fructose results in increased expression of INS protein]; INS protein inhibits the reaction [Fructose results in increased expression of AGTR1A mRNA]; Quercetin inhibits the reaction [Fructose results in increased expression of INS2 mRNA]
CTD PMID:12010179 PMID:18360027 PMID:23533474 PMID:25268984 PMID:26713546 NCBI chr 7:142,678,656...142,679,726
Ensembl chr 7:142,678,656...142,743,381
JBrowse link
G Insig1 insulin induced gene 1 decreases expression
increases expression
multiple interactions
EXP Fructose results in decreased expression of INSIG1 protein
Fructose results in increased expression of INSIG1 mRNA
Phenylbutyrates inhibits the reaction [Fructose results in decreased expression of INSIG1 protein]
CTD PMID:22698815 NCBI chr 5:28,071,412...28,078,662
Ensembl chr 5:28,071,363...28,078,662
JBrowse link
G Insig2 insulin induced gene 2 increases expression EXP Fructose results in increased expression of INSIG2 mRNA CTD PMID:22698815 NCBI chr 1:121,304,353...121,332,662
Ensembl chr 1:121,304,353...121,332,589
JBrowse link
G Insr insulin receptor decreases expression
multiple interactions
decreases phosphorylation
ISO Fructose results in decreased expression of INSR mRNA; Fructose results in decreased expression of INSR protein
[Fructose co-treated with Oleanolic Acid] results in increased expression of INSR mRNA; [Fructose co-treated with Sodium Chloride, Dietary deficiency] results in decreased expression of INSR mRNA; [Fructose co-treated with Sodium Chloride, Dietary deficiency] results in decreased expression of INSR protein; Allopurinol inhibits the reaction [Fructose results in decreased phosphorylation of INSR protein]; Quercetin inhibits the reaction [Fructose results in decreased phosphorylation of INSR protein]; Rutin inhibits the reaction [Fructose results in decreased phosphorylation of INSR protein]
CTD PMID:14573337 PMID:14633139 PMID:22426011 PMID:24491314 PMID:24704288 NCBI chr 8:3,150,922...3,279,649
Ensembl chr 8:3,122,061...3,279,617
JBrowse link
G Irf3 interferon regulatory factor 3 multiple interactions EXP [Fructose co-treated with Ethanol] results in increased expression of IRF3 protein; Fructose promotes the reaction [Ethanol results in increased expression of IRF3 mRNA] CTD PMID:26858005 NCBI chr 7:44,997,648...45,002,848
Ensembl chr 7:44,997,648...45,002,848
JBrowse link
G Irf7 interferon regulatory factor 7 increases expression
multiple interactions
EXP Fructose results in increased expression of IRF7 protein
[Fructose co-treated with Ethanol] results in increased expression of IRF7 protein
CTD PMID:26858005 NCBI chr 7:141,263,183...141,266,499
Ensembl chr 7:141,262,706...141,266,481
JBrowse link
G Irs1 insulin receptor substrate 1 decreases expression
increases phosphorylation
decreases phosphorylation
multiple interactions
affects phosphorylation
ISO
EXP
Fructose results in decreased expression of IRS1 mRNA; Fructose results in decreased expression of IRS1 protein
Fructose results in increased phosphorylation of IRS1 protein
Fructose results in decreased phosphorylation of IRS1 protein
[Fructose co-treated with Oleanolic Acid] results in increased expression of IRS1 mRNA; [Fructose co-treated with Oleanolic Acid] results in increased expression of IRS1 protein; [Fructose co-treated with resveratrol] results in increased expression of IRS1 mRNA; Allopurinol inhibits the reaction [Fructose results in decreased phosphorylation of IRS1 protein]; Curcumin inhibits the reaction [Fructose affects the phosphorylation of IRS1 protein]; NOS3 protein inhibits the reaction [Fructose results in decreased expression of IRS1 protein]; Oleanolic Acid inhibits the reaction [Fructose results in increased phosphorylation of IRS1 protein]; Quercetin inhibits the reaction [Fructose results in decreased phosphorylation of IRS1 protein]; Rutin inhibits the reaction [Fructose results in decreased phosphorylation of IRS1 protein]
CTD PMID:19008412 PMID:19165636 PMID:22426011 PMID:24704288 PMID:26488877 PMID:26713546 PMID:31672515 NCBI chr 1:82,233,105...82,291,439
Ensembl chr 1:82,233,112...82,235,933
Ensembl chr 1:82,233,112...82,235,933
JBrowse link
G Irs2 insulin receptor substrate 2 decreases expression
multiple interactions
ISO Fructose results in decreased expression of IRS2 mRNA; Fructose results in decreased expression of IRS2 protein
NOS3 protein inhibits the reaction [Fructose results in decreased expression of IRS2 protein]; resveratrol inhibits the reaction [Fructose results in decreased expression of IRS2 mRNA]
CTD PMID:19008412 PMID:19165636 PMID:26488877 NCBI chr 8:10,984,681...11,008,929
Ensembl chr 8:10,984,681...11,008,458
JBrowse link
G Itgb1 integrin beta 1 (fibronectin receptor beta) decreases expression ISO Fructose results in decreased expression of ITGB1 mRNA CTD PMID:31655124 NCBI chr 8:128,685,654...128,733,579
Ensembl chr 8:128,685,654...128,733,200
JBrowse link
G Itih3 inter-alpha trypsin inhibitor, heavy chain 3 decreases expression ISO Fructose results in decreased expression of ITIH3 protein CTD PMID:26930160 NCBI chr14:30,908,572...30,923,787
Ensembl chr14:30,908,572...30,923,760
JBrowse link
G Jak2 Janus kinase 2 decreases phosphorylation
multiple interactions
ISO Fructose results in decreased phosphorylation of JAK2 protein
Quercetin inhibits the reaction [Fructose results in decreased phosphorylation of JAK2 protein]; Rutin inhibits the reaction [Fructose results in decreased phosphorylation of JAK2 protein]
CTD PMID:22426011 NCBI chr19:29,251,803...29,313,095
Ensembl chr19:29,251,828...29,313,080
JBrowse link
G Jun jun proto-oncogene multiple interactions
increases expression
ISO Dactinomycin inhibits the reaction [Fructose results in increased expression of JUN mRNA] CTD PMID:11123204 PMID:11557636 NCBI chr 4:95,049,036...95,052,222
Ensembl chr 4:95,049,034...95,052,222
JBrowse link
G Jup junction plakoglobin multiple interactions ISO [Fructose co-treated with bisphenol A] results in increased expression of JUP protein CTD PMID:26930160 NCBI chr11:100,368,856...100,397,839
Ensembl chr11:100,368,958...100,397,763
JBrowse link
G Kdr kinase insert domain protein receptor multiple interactions ISO [bisphenol A co-treated with Fructose] results in increased expression of KDR mRNA CTD PMID:27622962 NCBI chr 5:75,932,827...75,979,072
Ensembl chr 5:75,932,827...75,978,458
JBrowse link
G Khk ketohexokinase multiple interactions
increases expression
ISO
EXP
KHK protein promotes the reaction [Fructose results in decreased abundance of Adenosine Triphosphate]; KHK protein promotes the reaction [Fructose results in increased abundance of Reactive Oxygen Species]; KHK protein promotes the reaction [Fructose results in increased secretion of CCL2 protein]
Atorvastatin inhibits the reaction [Fructose results in increased expression of KHK protein]
Fructose results in increased expression of KHK mRNA; Fructose results in increased expression of KHK protein
FGF21 gene mutant form inhibits the reaction [Fructose results in increased expression of KHK mRNA]; Fructose results in increased expression of and results in increased activity of KHK protein
CTD PMID:15066988 PMID:18346472 PMID:18395287 PMID:19158351 PMID:21122807 PMID:26858005 PMID:28123933 NCBI chr 5:30,921,436...30,931,248
Ensembl chr 5:30,921,431...30,931,248
JBrowse link
G Klk1 kallikrein 1 multiple interactions ISO KLK1 protein inhibits the reaction [Fructose results in increased expression of AGTR1B mRNA]; KLK1 protein inhibits the reaction [Fructose results in increased expression of EDN1 mRNA]; KLK1 protein inhibits the reaction [Fructose results in increased expression of EDNRA mRNA] CTD PMID:14568997 NCBI chr 7:44,225,360...44,229,622
Ensembl chr 7:44,225,360...44,229,618
JBrowse link
G Kng2 kininogen 2 decreases expression ISO Fructose results in decreased expression of MAP1 protein CTD PMID:26930160 NCBI chr16:22,985,852...23,029,101
Ensembl chr16:22,985,854...23,029,482
JBrowse link
G Krt18 keratin 18 increases expression ISO Fructose increases expression of Krt18 protein in liver and serum RGD PMID:29989845 RGD:26884460 NCBI chr15:102,028,216...102,032,026
Ensembl chr15:102,028,180...102,032,027
JBrowse link
G Lcn2 lipocalin 2 multiple interactions ISO [dapagliflozin co-treated with Atorvastatin] inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of LCN2 protein]; [Fructose co-treated with Dietary Fats] results in increased expression of LCN2 protein; [Streptozocin co-treated with Fructose] results in increased expression of LCN2 protein; Atorvastatin inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of LCN2 protein]; dapagliflozin inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of LCN2 protein]; dapagliflozin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of LCN2 protein]; Metformin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of LCN2 protein] CTD PMID:30551545 PMID:32259528 NCBI chr 2:32,384,637...32,387,739
Ensembl chr 2:32,384,633...32,388,252
JBrowse link
G Lct lactase increases expression ISO Fructose results in increased expression of LCT mRNA CTD PMID:11242478 NCBI chr 1:128,284,756...128,328,318
Ensembl chr 1:128,284,756...128,328,318
JBrowse link
G Ldhb lactate dehydrogenase B multiple interactions ISO [Fructose co-treated with bisphenol A] results in decreased expression of LDHB protein CTD PMID:26930160 NCBI chr 6:142,490,249...142,507,957
Ensembl chr 6:142,490,249...142,507,957
JBrowse link
G Lep leptin increases secretion
increases expression
multiple interactions
ISO Fructose results in increased secretion of LEP protein
Fructose results in increased expression of LEP mRNA; Fructose results in increased expression of LEP protein
[Fenofibrate co-treated with Resveratrol] inhibits the reaction [Fructose results in increased expression of LEP mRNA]; [Ozone co-treated with Fructose] results in increased expression of LEP mRNA; [Particulate Matter co-treated with Fructose] results in increased expression of LEP mRNA; [Particulate Matter co-treated with Ozone co-treated with Fructose] results in increased expression of LEP mRNA; Allopurinol inhibits the reaction [Fructose results in increased expression of LEP protein]; Atorvastatin affects the reaction [Fructose results in increased expression of LEP protein]; Fenofibrate inhibits the reaction [Fructose results in increased expression of LEP mRNA]; Quercetin inhibits the reaction [Fructose results in increased expression of LEP protein]; Quercetin inhibits the reaction [Fructose results in increased secretion of LEP protein]; Resveratrol inhibits the reaction [Fructose results in increased expression of LEP mRNA]; Rutin inhibits the reaction [Fructose results in increased expression of LEP protein]
CTD PMID:10780946 PMID:11741341 PMID:18627777 PMID:19165636 PMID:21122807 PMID:22426011 PMID:23016136 PMID:23533474 PMID:23968387 PMID:26973390 NCBI chr 6:29,060,221...29,073,876
Ensembl chr 6:29,060,220...29,073,877
JBrowse link
G Lepr leptin receptor multiple interactions ISO Allopurinol inhibits the reaction [Fructose results in increased expression of and results in increased phosphorylation of LEPR protein]; Fructose results in increased expression of and results in increased phosphorylation of LEPR protein; Quercetin inhibits the reaction [Fructose results in increased expression of and results in increased phosphorylation of LEPR protein]; Rutin inhibits the reaction [Fructose results in increased expression of and results in increased phosphorylation of LEPR protein] CTD PMID:22426011 NCBI chr 4:101,717,137...101,815,352
Ensembl chr 4:101,717,404...101,815,352
JBrowse link
G Lgals9 lectin, galactose binding, soluble 9 decreases expression
multiple interactions
ISO Fructose results in decreased expression of LGALS9 mRNA; Fructose results in decreased expression of LGALS9 protein
Allopurinol inhibits the reaction [Fructose results in decreased expression of LGALS9 mRNA]; Allopurinol inhibits the reaction [Fructose results in decreased expression of LGALS9 protein]; Quercetin inhibits the reaction [Fructose results in decreased expression of LGALS9 mRNA]; Quercetin inhibits the reaction [Fructose results in decreased expression of LGALS9 protein]; Rutin inhibits the reaction [Fructose results in decreased expression of LGALS9 mRNA]; Rutin inhibits the reaction [Fructose results in decreased expression of LGALS9 protein]
CTD PMID:19605544 NCBI chr11:78,962,979...78,984,924
Ensembl chr11:78,962,974...78,984,946
JBrowse link
G Maoa monoamine oxidase A multiple interactions ISO [Fructose co-treated with bisphenol A] results in increased expression of MAOA protein CTD PMID:26930160 NCBI chr  X:16,619,698...16,687,812
Ensembl chr  X:16,619,698...16,687,818
JBrowse link
G Mapk1 mitogen-activated protein kinase 1 increases phosphorylation
decreases phosphorylation
multiple interactions
ISO Fructose results in increased phosphorylation of MAPK1 protein
Fructose results in decreased phosphorylation of MAPK1 protein
Curcumin inhibits the reaction [Fructose results in increased phosphorylation of MAPK1 protein]; Quercetin inhibits the reaction [Fructose results in decreased phosphorylation of MAPK1 protein]; Rutin inhibits the reaction [Fructose results in decreased phosphorylation of MAPK1 protein]
CTD PMID:22426011 PMID:26713546 NCBI chr16:16,983,382...17,047,453
Ensembl chr16:16,983,382...17,047,453
JBrowse link
G Mapk3 mitogen-activated protein kinase 3 increases phosphorylation
decreases phosphorylation
multiple interactions
ISO Fructose results in increased phosphorylation of MAPK3 protein
Fructose results in decreased phosphorylation of MAPK3 protein
Curcumin inhibits the reaction [Fructose results in increased phosphorylation of MAPK3 protein]; Quercetin inhibits the reaction [Fructose results in decreased phosphorylation of MAPK3 protein]; Rutin inhibits the reaction [Fructose results in decreased phosphorylation of MAPK3 protein]
CTD PMID:22426011 PMID:26713546 NCBI chr 7:126,759,626...126,765,816
Ensembl chr 7:126,759,601...126,765,819
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases expression
multiple interactions
ISO Fructose results in increased expression of MAPK8 protein
imoxin inhibits the reaction [Fructose results in increased expression of MAPK8 protein]
CTD PMID:29430716 NCBI chr14:33,377,898...33,447,353
Ensembl chr14:33,377,898...33,447,158
JBrowse link
G Mfn2 mitofusin 2 multiple interactions ISO [Fructose co-treated with Palmitic Acid] results in decreased expression of MFN2 protein; Fenofibrate inhibits the reaction [[Fructose co-treated with Palmitic Acid] results in decreased expression of MFN2 protein] CTD PMID:32730863 NCBI chr 4:147,873,586...147,904,909
Ensembl chr 4:147,873,599...147,904,704
JBrowse link
G Mir33 microRNA 33 multiple interactions ISO [Fructose co-treated with Streptozocin] results in increased expression of MIR33A mRNA; Ghrelin inhibits the reaction [[Fructose co-treated with Streptozocin] results in increased expression of MIR33A mRNA] CTD PMID:31468622 NCBI chr15:82,198,122...82,198,190
Ensembl chr15:82,198,122...82,198,190
JBrowse link
G Mlx MAX-like protein X increases expression ISO Fructose results in increased expression of MLX mRNA CTD PMID:18346472 NCBI chr11:101,086,707...101,092,207
Ensembl chr11:101,087,277...101,092,207
JBrowse link
G Mlxipl MLX interacting protein-like multiple interactions
increases expression
decreases expression
increases activity
ISO
EXP
Atorvastatin inhibits the reaction [Fructose affects the localization of and results in increased activity of MLXIPL protein]; Atorvastatin inhibits the reaction [Fructose results in increased expression of MLXIPL protein]; Fructose affects the localization of and results in increased activity of MLXIPL protein; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Atorvastatin inhibits the reaction [Fructose results in increased activity of MLXIPL protein]]
FGF21 gene mutant form inhibits the reaction [Fructose results in increased expression of MLXIPL mRNA alternative form]; MLXIPL gene mutant form inhibits the reaction [Fructose results in increased expression of FGF21 mRNA]; MLXIPL gene mutant form inhibits the reaction [Fructose results in increased secretion of FGF21 protein]
Fructose results in decreased expression of MLXIPL mRNA
Fructose results in increased expression of MLXIPL mRNA; Fructose results in increased expression of MLXIPL protein
CTD PMID:18346472 PMID:19053045 PMID:19799862 PMID:21122807 PMID:28123933 NCBI chr 5:135,089,890...135,139,768
Ensembl chr 5:135,089,890...135,138,382
JBrowse link
G Mlycd malonyl-CoA decarboxylase multiple interactions
decreases expression
ISO [Fenofibrate co-treated with resveratrol] inhibits the reaction [Fructose results in decreased expression of MLYCD mRNA]; Fenofibrate inhibits the reaction [Fructose results in decreased expression of MLYCD mRNA]; resveratrol inhibits the reaction [Fructose results in decreased expression of MLYCD mRNA] CTD PMID:26973390 NCBI chr 8:119,394,852...119,421,838
Ensembl chr 8:119,394,878...119,411,102
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions EXP [FGF21 gene mutant form results in increased susceptibility to Fructose] which results in increased expression of MMP2 mRNA CTD PMID:28123933 NCBI chr 8:92,827,290...92,853,421
Ensembl chr 8:92,827,291...92,853,420
JBrowse link
G Mmp9 matrix metallopeptidase 9 increases expression ISO Fructose results in increased expression of MMP9 mRNA CTD PMID:31655124 NCBI chr 2:164,940,326...164,955,850
Ensembl chr 2:164,940,780...164,955,850
JBrowse link
G Mpst mercaptopyruvate sulfurtransferase multiple interactions ISO [Fructose co-treated with bisphenol A] results in decreased expression of MPST protein CTD PMID:26930160 NCBI chr15:78,406,712...78,414,015
Ensembl chr15:78,406,416...78,414,013
JBrowse link
G Msn moesin multiple interactions ISO [Fructose co-treated with bisphenol A] results in increased expression of MSN protein CTD PMID:26930160 NCBI chr  X:96,096,045...96,168,553
Ensembl chr  X:96,096,042...96,168,552
JBrowse link
G mt-Atp6 ATP synthase 6, mitochondrial increases expression ISO Fructose results in increased expression of ATP6 protein CTD PMID:11934685 NCBI chr MT:7,927...8,607
Ensembl chr MT:7,927...8,607
JBrowse link
G mt-Co2 cytochrome c oxidase II, mitochondrial multiple interactions ISO [Fructose co-treated with bisphenol A] results in decreased expression of COX2 protein CTD PMID:26930160 NCBI chr MT:7,013...7,696
Ensembl chr MT:7,013...7,696
JBrowse link
G Mt2 metallothionein 2 multiple interactions
increases expression
ISO Atorvastatin inhibits the reaction [Fructose results in increased expression of MT2A mRNA] CTD PMID:21122807 NCBI chr 8:94,172,618...94,173,567
Ensembl chr 8:94,172,664...94,173,568
JBrowse link
G Mttp microsomal triglyceride transfer protein multiple interactions
increases expression
ISO
EXP
[Fructose co-treated with Copper deficiency] results in decreased expression of MTTP mRNA
FGF21 gene mutant form inhibits the reaction [Fructose results in increased expression of MTTP mRNA]
CTD PMID:25813056 PMID:28123933 NCBI chr 3:138,089,855...138,143,418
Ensembl chr 3:138,089,854...138,144,968
JBrowse link
G Myc myelocytomatosis oncogene decreases expression ISO Fructose results in decreased expression of MYC mRNA CTD PMID:2558650 NCBI chr15:61,985,341...61,990,361
Ensembl chr15:61,985,391...61,990,374
JBrowse link
G Myd88 myeloid differentiation primary response gene 88 multiple interactions EXP Fructose promotes the reaction [Ethanol results in increased expression of MYD88 mRNA] CTD PMID:26858005 NCBI chr 9:119,335,934...119,340,018
Ensembl chr 9:119,335,934...119,341,411
JBrowse link
G Myh6 myosin, heavy polypeptide 6, cardiac muscle, alpha increases expression
multiple interactions
EXP Fructose results in increased expression of MYH6 mRNA
SIRT1 protein affects the reaction [Fructose results in increased expression of MYH6 mRNA]
CTD PMID:18192211 NCBI chr14:54,941,921...54,968,017
Ensembl chr14:54,941,921...54,966,927
JBrowse link
G Myh9 myosin, heavy polypeptide 9, non-muscle decreases expression
multiple interactions
ISO Fructose results in decreased expression of MYH9 protein
[Fructose co-treated with bisphenol A] results in increased expression of MYH9 protein
CTD PMID:26930160 NCBI chr15:77,760,585...77,842,175
Ensembl chr15:77,760,587...77,842,175
JBrowse link
G Ndufa5 NADH:ubiquinone oxidoreductase subunit A5 multiple interactions ISO [Fructose co-treated with bisphenol A] results in increased expression of NDUFA5 protein CTD PMID:26930160 NCBI chr 6:24,518,662...24,527,690
Ensembl chr 6:24,518,666...24,528,013
JBrowse link
G Ndufa9 NADH:ubiquinone oxidoreductase subunit A9 multiple interactions ISO [Fructose co-treated with bisphenol A] results in decreased expression of NDUFA9 protein CTD PMID:26930160 NCBI chr 6:126,821,863...126,849,144
Ensembl chr 6:126,821,721...126,849,136
JBrowse link
G Nfatc4 nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 4 increases expression
multiple interactions
ISO Fructose results in increased expression of NFATC4 protein
tributylhexadecylphosphonium bromide inhibits the reaction [Fructose results in increased expression of NFATC4 protein]
CTD PMID:26358169 NCBI chr14:55,824,795...55,833,943
Ensembl chr14:55,823,144...55,833,943
JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 increases expression
multiple interactions
EXP
ISO
Fructose results in increased expression of NFE2L2 protein
[Fructose co-treated with Palmitic Acid] results in decreased expression of NFE2L2 protein; Fenofibrate inhibits the reaction [[Fructose co-treated with Palmitic Acid] results in decreased expression of NFE2L2 protein]
[Atorvastatin co-treated with dapagliflozin] inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of NFE2L2 protein]; [Fructose co-treated with Dietary Fats] results in increased expression of NFE2L2 protein; Atorvastatin inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of NFE2L2 protein]; dapagliflozin inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of NFE2L2 protein]
Fructose promotes the reaction [PPARD gene mutant form results in increased phosphorylation of NFE2L2 protein]; Plant Preparations inhibits the reaction [Fructose results in increased expression of NFE2L2 protein]
CTD PMID:27531227 PMID:29289645 PMID:32259528 PMID:32730863 NCBI chr 2:75,675,513...75,704,663
Ensembl chr 2:75,675,513...75,704,641
JBrowse link
G Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha increases degradation
increases phosphorylation
multiple interactions
ISO Fructose results in increased degradation of NFKBIA protein
Fructose results in increased phosphorylation of NFKBIA protein
Allopurinol inhibits the reaction [Fructose results in increased phosphorylation of NFKBIA protein]; Curcumin inhibits the reaction [Fructose results in increased degradation of NFKBIA protein]; Quercetin inhibits the reaction [Fructose results in increased phosphorylation of NFKBIA protein]
CTD PMID:24491314 PMID:26713546 NCBI chr12:55,489,409...55,492,647
Ensembl chr12:55,489,410...55,492,647
JBrowse link
G Ngf nerve growth factor decreases expression ISO Fructose results in decreased expression of NGF mRNA; Fructose results in decreased expression of NGF protein CTD PMID:18585860 NCBI chr 3:102,469,919...102,521,013
Ensembl chr 3:102,469,919...102,521,013
JBrowse link
G Ngfr nerve growth factor receptor (TNFR superfamily, member 16) decreases expression ISO Fructose results in decreased expression of NGFR mRNA CTD PMID:18585860 NCBI chr11:95,568,818...95,587,698
Ensembl chr11:95,568,818...95,587,735
JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 increases expression
multiple interactions
ISO Fructose results in increased expression of NLRP3 protein
Allopurinol inhibits the reaction [Fructose results in increased expression of NLRP3 protein]; Quercetin inhibits the reaction [Fructose results in increased expression of NLRP3 protein]; Rutin inhibits the reaction [Fructose results in increased expression of NLRP3 protein]
CTD PMID:22426011 PMID:24491314 NCBI chr11:59,541,569...59,566,955
Ensembl chr11:59,541,568...59,566,956
JBrowse link
G Nos2 nitric oxide synthase 2, inducible multiple interactions
increases expression
ISO
EXP
2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [caryophyllene inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of NOS2 protein]]; [Dietary Fats co-treated with Fructose] results in increased expression of NOS2 protein; [Fructose results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide; caryophyllene inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of NOS2 protein]; iodopravadoline inhibits the reaction [caryophyllene inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of NOS2 protein]]; Pioglitazone inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of NOS2 protein]; Resveratrol inhibits the reaction [Fructose results in increased expression of NOS2 mRNA]; Resveratrol inhibits the reaction [Fructose results in increased expression of NOS2 protein]
Fructose results in increased expression of NOS2 mRNA; Fructose results in increased expression of NOS2 protein
CTD PMID:10090849 PMID:26488877 PMID:28257781 PMID:30343038 NCBI chr11:78,920,787...78,960,226
Ensembl chr11:78,920,787...78,960,254
JBrowse link
G Nos3 nitric oxide synthase 3, endothelial cell multiple interactions
decreases expression
decreases phosphorylation
decreases activity
ISO 2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [caryophyllene inhibits the reaction [[Dietary Fats co-treated with Fructose] results in decreased expression of NOS3 protein]]; [bisphenol A co-treated with Fructose] results in increased expression of NOS3 mRNA; [Dietary Fats co-treated with Fructose] results in decreased expression of NOS3 protein; [Resveratrol co-treated with Fructose] results in increased expression of NOS3 mRNA; caryophyllene inhibits the reaction [[Dietary Fats co-treated with Fructose] results in decreased expression of NOS3 protein]; Fish Oils inhibits the reaction [Fructose results in decreased expression of NOS3 mRNA]; Fish Oils inhibits the reaction [Fructose results in decreased expression of NOS3 protein]; iodopravadoline inhibits the reaction [caryophyllene inhibits the reaction [[Dietary Fats co-treated with Fructose] results in decreased expression of NOS3 protein]]; Metformin inhibits the reaction [Fructose results in decreased phosphorylation of NOS3 protein]; NOS3 protein inhibits the reaction [Fructose results in decreased expression of IRS1 protein]; NOS3 protein inhibits the reaction [Fructose results in decreased expression of IRS2 protein]; NOS3 protein inhibits the reaction [Fructose results in decreased phosphorylation of AKT1 protein]; Pioglitazone inhibits the reaction [[Dietary Fats co-treated with Fructose] results in decreased expression of NOS3 protein]; Resveratrol inhibits the reaction [Fructose results in decreased expression of NOS3 mRNA]; Resveratrol inhibits the reaction [Fructose results in decreased expression of NOS3 protein]; Resveratrol inhibits the reaction [Fructose results in decreased phosphorylation of NOS3 protein]
Fructose results in decreased expression of NOS3 mRNA; Fructose results in decreased expression of NOS3 protein
Fructose results in decreased activity of NOS3 protein
CTD PMID:10580434 PMID:15752949 PMID:18508964 PMID:19008412 PMID:25108154 PMID:26488877 PMID:27622962 PMID:30343038 NCBI chr 5:24,364,816...24,384,474
Ensembl chr 5:24,364,810...24,384,474
JBrowse link
G Nox4 NADPH oxidase 4 increases expression ISO Fructose results in increased expression of NOX4 mRNA CTD PMID:17587757 NCBI chr 7:87,244,430...87,398,710
Ensembl chr 7:87,246,096...87,398,710
JBrowse link
G Nphs1 nephrosis 1, nephrin multiple interactions ISO [Streptozocin co-treated with Fructose] results in decreased expression of NPHS1 mRNA; dapagliflozin inhibits the reaction [[Streptozocin co-treated with Fructose] results in decreased expression of NPHS1 mRNA]; Metformin inhibits the reaction [[Streptozocin co-treated with Fructose] results in decreased expression of NPHS1 mRNA] CTD PMID:30551545 NCBI chr 7:30,458,207...30,488,623
Ensembl chr 7:30,458,315...30,487,223
JBrowse link
G Npy neuropeptide Y decreases expression ISO Fructose results in decreased expression of NPY mRNA CTD PMID:18627777 NCBI chr 6:49,822,710...49,829,507
Ensembl chr 6:49,822,710...49,829,507
JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 multiple interactions EXP NR0B2 protein inhibits the reaction [AHR protein results in increased susceptibility to [Dietary Fats co-treated with Fructose]]; NR0B2 protein results in decreased susceptibility to [Dietary Fats co-treated with Fructose] CTD PMID:29416063 NCBI chr 4:133,553,376...133,556,686
Ensembl chr 4:133,553,376...133,556,536
JBrowse link
G Nr2f1 nuclear receptor subfamily 2, group F, member 1 multiple interactions ISO Fructose affects the reaction [NR2F1 protein binds to SHBG promoter] CTD PMID:17992261 NCBI chr13:78,188,971...78,198,873
Ensembl chr13:78,188,973...78,199,757
JBrowse link
G Oat ornithine aminotransferase multiple interactions ISO Fructose inhibits the reaction [Cyclic AMP results in increased activity of OAT protein]; Fructose inhibits the reaction [Cyclic AMP results in increased expression of OAT mRNA] CTD PMID:2827574 NCBI chr 7:132,557,475...132,576,398
Ensembl chr 7:132,557,478...132,576,398
JBrowse link
G Oga O-GlcNAcase multiple interactions ISO [Streptozocin co-treated with Fructose] results in increased expression of and results in increased secretion of OGA protein; dapagliflozin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of and results in increased secretion of OGA protein]; Metformin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of and results in increased secretion of OGA protein] CTD PMID:30551545 NCBI chr19:45,750,255...45,783,644
Ensembl chr19:45,750,259...45,783,837
JBrowse link
G Opa1 OPA1, mitochondrial dynamin like GTPase multiple interactions ISO [Fructose co-treated with Palmitic Acid] results in decreased expression of OPA1 protein; Fenofibrate inhibits the reaction [[Fructose co-treated with Palmitic Acid] results in decreased expression of OPA1 protein] CTD PMID:32730863 NCBI chr16:29,579,281...29,663,127
Ensembl chr16:29,579,334...29,654,884
JBrowse link
G Paip2 polyadenylate-binding protein-interacting protein 2 multiple interactions ISO Fructose promotes the reaction [PAIP2 protein binds to SLC2A5 3' UTR] CTD PMID:12820898 NCBI chr18:35,598,610...35,617,186
Ensembl chr18:35,598,617...35,617,187
JBrowse link
G Parp1 poly (ADP-ribose) polymerase family, member 1 increases expression EXP Fructose results in increased expression of PARP1 protein CTD PMID:28257781 NCBI chr 1:180,568,891...180,600,999
Ensembl chr 1:180,568,924...180,601,254
JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1, cytosolic multiple interactions
increases expression
increases activity
ISO rosiglitazone inhibits the reaction [Fructose results in increased expression of PCK1 mRNA]; rosiglitazone inhibits the reaction [Fructose results in increased expression of PCK1 protein]
Fructose results in increased expression of PCK1 mRNA; Fructose results in increased expression of PCK1 protein
Fructose results in increased activity of PCK1 protein
CTD PMID:19196556 PMID:21212096 NCBI chr 2:173,153,073...173,159,274
Ensembl chr 2:173,153,048...173,159,273
JBrowse link
G Pcmt1 protein-L-isoaspartate (D-aspartate) O-methyltransferase 1 multiple interactions ISO [Fructose co-treated with bisphenol A] results in increased expression of PCMT1 protein CTD PMID:26930160 NCBI chr10:7,627,845...7,681,337
Ensembl chr10:7,629,373...7,681,136
JBrowse link
G Pdk1 pyruvate dehydrogenase kinase, isoenzyme 1 multiple interactions ISO [Fructose co-treated with bisphenol A] results in increased expression of PDK1 protein CTD PMID:26930160 NCBI chr 2:71,873,215...71,903,858
Ensembl chr 2:71,873,224...71,903,858
JBrowse link
G Pdx1 pancreatic and duodenal homeobox 1 increases expression
multiple interactions
ISO Fructose results in increased expression of PDX1 mRNA; Fructose results in increased expression of PDX1 protein
Quercetin inhibits the reaction [Fructose results in increased expression of PDX1 protein]
CTD PMID:23533474 NCBI chr 5:147,270,097...147,275,848
Ensembl chr 5:147,269,959...147,275,848
JBrowse link
G Pemt phosphatidylethanolamine N-methyltransferase multiple interactions EXP [Dietary Fats co-treated with Fructose] results in increased expression of PEMT mRNA; PEMT protein promotes the reaction [AHR protein results in increased susceptibility to [Dietary Fats co-treated with Fructose]] CTD PMID:29416063 NCBI chr11:59,970,614...60,046,561
Ensembl chr11:59,970,614...60,046,489
JBrowse link
G Pf4 platelet factor 4 increases expression ISO Fructose results in increased expression of PF4 mRNA CTD PMID:31655124 NCBI chr 5:90,772,435...90,773,383
Ensembl chr 5:90,772,435...90,773,383
JBrowse link
G Pfkl phosphofructokinase, liver, B-type increases expression ISO Fructose results in increased expression of PFKL mRNA CTD PMID:18346472 NCBI chr10:77,986,947...78,009,807
Ensembl chr10:77,986,947...78,010,083
JBrowse link
G Phb2 prohibitin 2 multiple interactions ISO [Fructose co-treated with bisphenol A] results in decreased expression of PHB2 protein CTD PMID:26930160 NCBI chr 6:124,712,289...124,716,945
Ensembl chr 6:124,712,336...124,716,950
JBrowse link
G Pik3c2g phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma multiple interactions ISO [Fructose co-treated with Oleanolic Acid] results in increased expression of PIK3C2G mRNA CTD PMID:24704288 NCBI chr 6:139,614,072...139,969,284
Ensembl chr 6:139,587,221...139,969,284
JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 multiple interactions ISO [Fructose co-treated with Dietary Fats] results in decreased expression of PIK3R1 protein CTD PMID:32259528 NCBI chr13:101,680,761...101,768,217
Ensembl chr13:101,680,563...101,768,217
JBrowse link
G Pklr pyruvate kinase liver and red blood cell increases expression
multiple interactions
affects expression
affects degradation
EXP
ISO
Fructose results in increased expression of PKLR mRNA
Atorvastatin inhibits the reaction [Fructose results in increased expression of PKLR mRNA]; GCG protein affects the reaction [Fructose affects the degradation of PKLR mRNA]
Fructose affects the expression of PKLR mRNA
FGF21 gene mutant form inhibits the reaction [Fructose results in increased expression of PKLR mRNA]; lactisole inhibits the reaction [Fructose results in increased expression of PKLR mRNA]
CTD PMID:2193023 PMID:2414297 PMID:2824512 PMID:6526814 PMID:6759123 PMID:17786952 PMID:18346472 PMID:19053045 PMID:21122807 PMID:28123933 NCBI chr 3:89,136,122...89,146,815
Ensembl chr 3:89,136,142...89,146,784
JBrowse link
G Pkm pyruvate kinase, muscle multiple interactions ISO [Fructose co-treated with bisphenol A] results in decreased expression of PKM protein CTD PMID:26930160 NCBI chr 9:59,656,576...59,679,372
Ensembl chr 9:59,656,368...59,679,375
JBrowse link
G Plat plasminogen activator, tissue increases expression ISO Fructose results in increased expression of PLAT mRNA CTD PMID:31655124 NCBI chr 8:22,757,722...22,782,848
Ensembl chr 8:22,757,727...22,782,844
JBrowse link
G Pnpla2 patatin-like phospholipase domain containing 2 increases expression EXP Fructose results in increased expression of PNPLA2 protein CTD PMID:28257781 NCBI chr 7:141,455,188...141,460,743
Ensembl chr 7:141,455,198...141,460,743
JBrowse link
G Pomc pro-opiomelanocortin-alpha decreases expression ISO Fructose results in decreased expression of POMC mRNA CTD PMID:18627777 NCBI chr12:3,954,945...3,960,643
Ensembl chr12:3,954,951...3,960,642
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha increases expression
multiple interactions
decreases expression
ISO
EXP
Fructose results in increased expression of PPARA protein
[Plant Preparations co-treated with Fructose] results in increased expression of PPARA protein
Fructose results in decreased expression of PPARA protein
[dapagliflozin co-treated with Atorvastatin] inhibits the reaction [[Fructose co-treated with Dietary Fats] results in decreased expression of PPARA protein]; [Fructose co-treated with Dietary Fats] results in decreased expression of PPARA protein; Allopurinol inhibits the reaction [Fructose results in decreased expression of PPARA protein]; Atorvastatin inhibits the reaction [Fructose results in increased expression of PPARA protein]; Fenofibrate inhibits the reaction [Fructose results in decreased expression of and results in decreased activity of PPARA protein]; Fructose results in decreased expression of and results in decreased activity of PPARA protein; Quercetin inhibits the reaction [Fructose results in decreased expression of PPARA protein]; Rutin inhibits the reaction [Fructose results in decreased expression of PPARA protein]
CTD PMID:11934685 PMID:12065722 PMID:22426011 PMID:27531227 PMID:28257781 PMID:32259528 NCBI chr15:85,734,910...85,806,851
Ensembl chr15:85,734,983...85,802,819
JBrowse link
G Ppard peroxisome proliferator activator receptor delta decreases response to substance
multiple interactions
EXP PPARD mRNA results in decreased susceptibility to Fructose
[PPARD mRNA results in decreased susceptibility to Fructose] which results in decreased expression of VLDLR mRNA; Fructose inhibits the reaction [PPARD mRNA results in decreased expression of VLDLR mRNA]; Fructose promotes the reaction [PPARD gene mutant form results in increased expression of VLDLR mRNA]; Fructose promotes the reaction [PPARD gene mutant form results in increased expression of VLDLR protein]; Fructose promotes the reaction [PPARD gene mutant form results in increased phosphorylation of NFE2L2 protein]
CTD PMID:29289645 NCBI chr17:28,232,754...28,301,469
Ensembl chr17:28,232,700...28,301,474
JBrowse link
G Pparg peroxisome proliferator activated receptor gamma increases expression
decreases activity
multiple interactions
ISO Fructose results in increased expression of PPARG mRNA
Fructose results in decreased activity of PPARG protein
[Dietary Fats co-treated with Fructose] results in decreased expression of PPARG protein; Carnitine inhibits the reaction [[Dietary Fats co-treated with Fructose] results in decreased expression of PPARG protein]; Fatty Acids, Omega-3 inhibits the reaction [[Dietary Fats co-treated with Fructose] results in decreased expression of PPARG protein]; geraniol inhibits the reaction [Fructose results in decreased activity of PPARG protein]; Metformin inhibits the reaction [[Dietary Fats co-treated with Fructose] results in decreased expression of PPARG protein]; Pioglitazone inhibits the reaction [Fructose results in decreased activity of PPARG protein]; Rosiglitazone promotes the reaction [Fructose results in increased expression of PPARG mRNA]
CTD PMID:19196556 PMID:25679220 PMID:30256492 NCBI chr 6:115,360,879...115,490,404
Ensembl chr 6:115,360,951...115,490,399
JBrowse link
G Ppargc1a peroxisome proliferative activated receptor, gamma, coactivator 1 alpha decreases expression
multiple interactions
increases expression
ISO Fructose results in decreased expression of PPARGC1A mRNA
[Fructose co-treated with Palmitic Acid] results in decreased expression of PPARGC1A protein; Fenofibrate inhibits the reaction [[Fructose co-treated with Palmitic Acid] results in decreased expression of PPARGC1A protein]
Fructose results in increased expression of PPARGC1A mRNA; Fructose results in increased expression of PPARGC1A protein
[Atorvastatin co-treated with dapagliflozin] inhibits the reaction [[Fructose co-treated with Dietary Fats] results in decreased expression of PPARGC1A protein]; [Fructose co-treated with Dietary Fats] results in decreased expression of PPARGC1A protein; [Ozone co-treated with Fructose] results in decreased expression of PPARGC1A mRNA; [Particulate Matter co-treated with Fructose] results in decreased expression of PPARGC1A mRNA; [Particulate Matter co-treated with Ozone co-treated with Fructose] results in decreased expression of PPARGC1A mRNA; dapagliflozin inhibits the reaction [[Fructose co-treated with Dietary Fats] results in decreased expression of PPARGC1A protein]; Rosiglitazone inhibits the reaction [Fructose results in increased expression of PPARGC1A protein]
CTD PMID:18063403 PMID:19196556 PMID:21212096 PMID:23968387 PMID:32259528 PMID:32730863 NCBI chr 5:51,454,249...52,115,853
Ensembl chr 5:51,454,250...51,567,726
JBrowse link
G Prdx6 peroxiredoxin 6 multiple interactions ISO [Fructose co-treated with bisphenol A] results in increased expression of PRDX6 protein CTD PMID:26930160 NCBI chr 1:161,240,112...161,251,210
Ensembl chr 1:161,240,112...161,251,219
JBrowse link
G Prkca protein kinase C, alpha multiple interactions ISO [Atorvastatin co-treated with dapagliflozin] inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of and results in increased phosphorylation of PRKCA protein]; [Fructose co-treated with Dietary Fats] results in increased expression of and results in increased phosphorylation of PRKCA protein CTD PMID:32259528 NCBI chr11:107,933,387...108,343,888
Ensembl chr11:107,933,387...108,343,928
JBrowse link
G Prkcq protein kinase C, theta multiple interactions
increases phosphorylation
ISO Curcumin inhibits the reaction [Fructose results in increased phosphorylation of PRKCQ protein] CTD PMID:26713546 NCBI chr 2:11,171,905...11,301,226
Ensembl chr 2:11,172,108...11,301,222
JBrowse link
G Prkcz protein kinase C, zeta multiple interactions ISO [Atorvastatin co-treated with dapagliflozin] inhibits the reaction [[Fructose co-treated with Dietary Fats] results in decreased expression of PRKCZ protein]; [Fructose co-treated with Dietary Fats] results in decreased expression of PRKCZ protein; dapagliflozin inhibits the reaction [[Fructose co-treated with Dietary Fats] results in decreased expression of PRKCZ protein] CTD PMID:32259528 NCBI chr 4:155,260,118...155,361,428
Ensembl chr 4:155,260,129...155,361,361
JBrowse link
G Pten phosphatase and tensin homolog multiple interactions
increases expression
ISO tributylhexadecylphosphonium bromide inhibits the reaction [Fructose results in increased expression of PTEN protein] CTD PMID:26358169 NCBI chr19:32,757,577...32,826,160
Ensembl chr19:32,757,497...32,826,160
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression
multiple interactions
ISO Fructose results in increased expression of PTGS2 mRNA; Fructose results in increased expression of PTGS2 protein
Curcumin inhibits the reaction [Fructose results in increased expression of PTGS2 protein]; Kangen-karyu inhibits the reaction [Fructose results in increased expression of PTGS2 protein]; tributylhexadecylphosphonium bromide inhibits the reaction [Fructose results in increased expression of PTGS2 protein]
CTD PMID:14757778 PMID:17883899 PMID:26358169 PMID:26713546 NCBI chr 1:150,100,031...150,108,234
Ensembl chr 1:150,100,031...150,108,227
JBrowse link
G Ptma prothymosin alpha multiple interactions ISO PTMA protein inhibits the reaction [Fructose results in increased expression of IL1B protein]; PTMA protein inhibits the reaction [Fructose results in increased expression of IL6 protein] CTD PMID:15885234 NCBI chr 1:86,526,557...86,530,712
Ensembl chr 1:86,526,726...86,530,712
JBrowse link
G Pura purine rich element binding protein A multiple interactions ISO [Fructose co-treated with bisphenol A] results in increased expression of PURA protein CTD PMID:26930160 NCBI chr18:36,280,560...36,292,535
Ensembl chr18:36,281,097...36,292,535
JBrowse link
G Pycard PYD and CARD domain containing multiple interactions
increases expression
ISO Allopurinol inhibits the reaction [Fructose results in increased expression of PYCARD protein]; Quercetin inhibits the reaction [Fructose results in increased expression of PYCARD protein]; Rutin inhibits the reaction [Fructose results in increased expression of PYCARD protein] CTD PMID:22426011 NCBI chr 7:127,991,373...127,993,867
Ensembl chr 7:127,989,708...127,993,867
JBrowse link
G Pyy peptide YY affects expression ISO Fructose affects the expression of PYY protein CTD PMID:18627777 NCBI chr11:102,106,676...102,107,832
Ensembl chr11:102,106,676...102,107,832
JBrowse link
G Rbmx RNA binding motif protein, X chromosome multiple interactions ISO Fructose promotes the reaction [RBMX protein binds to SREBF1 promoter] CTD PMID:17188681 NCBI chr  X:57,383,348...57,393,046
Ensembl chr  X:57,383,530...57,393,036
JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) affects localization
increases phosphorylation
decreases activity
multiple interactions
ISO Fructose affects the localization of RELA protein
Fructose results in increased phosphorylation of RELA protein
Fructose results in decreased activity of RELA protein
Allopurinol inhibits the reaction [Fructose results in increased phosphorylation of RELA protein]; Betaine inhibits the reaction [Fructose results in decreased activity of RELA protein]; galangin inhibits the reaction [Fructose affects the localization of RELA protein]; Genistein inhibits the reaction [Fructose affects the localization of RELA protein]; Metformin inhibits the reaction [Fructose results in increased phosphorylation of RELA protein]; Quercetin inhibits the reaction [Fructose results in increased phosphorylation of RELA protein]; resveratrol inhibits the reaction [Fructose results in increased phosphorylation of RELA protein]
CTD PMID:21704028 PMID:21708140 PMID:24491314 PMID:25108154 PMID:25559852 NCBI chr19:5,637,442...5,648,134
Ensembl chr19:5,637,483...5,648,130
JBrowse link
G Retn resistin decreases expression
multiple interactions
increases expression
ISO Fructose results in decreased expression of RETN mRNA
Metformin inhibits the reaction [Fructose results in increased expression of RETN protein]; resveratrol inhibits the reaction [Fructose results in increased expression of RETN protein]
CTD PMID:11741341 PMID:25108154 NCBI chr 8:3,655,770...3,659,818
Ensembl chr 8:3,655,770...3,660,110
JBrowse link
G Rxra retinoid X receptor alpha decreases expression EXP Fructose results in decreased expression of RXRA protein CTD PMID:28257781 NCBI chr 2:27,676,445...27,763,319
Ensembl chr 2:27,676,440...27,762,957
JBrowse link
G S100a11 S100 calcium binding protein A11 multiple interactions ISO [Fructose co-treated with bisphenol A] results in increased expression of S100A11 protein CTD PMID:26930160 NCBI chr 3:93,520,496...93,526,288
Ensembl chr 3:93,520,488...93,526,287
JBrowse link
G S100a6 S100 calcium binding protein A6 (calcyclin) decreases expression ISO Fructose results in decreased expression of S100A6 mRNA CTD PMID:15150374 NCBI chr 3:90,612,894...90,614,414
Ensembl chr 3:90,612,882...90,624,181
JBrowse link
G Scarb1 scavenger receptor class B, member 1 decreases expression ISO Fructose results in decreased expression of SCARB1 mRNA CTD PMID:19193814 NCBI chr 5:125,277,087...125,341,094
Ensembl chr 5:125,277,087...125,341,094
JBrowse link
G Scd1 stearoyl-Coenzyme A desaturase 1 multiple interactions
increases expression
affects response to substance
EXP
ISO
FGF21 gene mutant form inhibits the reaction [Fructose results in increased expression of SCD1 mRNA]; Phenylbutyrates inhibits the reaction [Fructose results in increased expression of SCD1 mRNA]; SCD1 affects the reaction [Fructose results in increased expression of SREBF1 protein]; SCD1 gene mutant form inhibits the reaction [Fructose results in increased abundance of Triglycerides]; SCD1 gene mutant form inhibits the reaction [Fructose results in increased expression of ACACA mRNA]; SCD1 gene mutant form inhibits the reaction [Fructose results in increased expression of FASN mRNA]; SCD1 gene mutant form inhibits the reaction [Fructose results in increased expression of SREBF1 mRNA]; SCD1 gene mutant form inhibits the reaction [Fructose results in increased expression of SREBF1 protein]; Triolein inhibits the reaction [SCD1 gene mutant form inhibits the reaction [Fructose results in increased abundance of Triglycerides]]; Triolein inhibits the reaction [SCD1 gene mutant form inhibits the reaction [Fructose results in increased expression of ACACA mRNA]]; Triolein inhibits the reaction [SCD1 gene mutant form inhibits the reaction [Fructose results in increased expression of FASN mRNA]]; Triolein inhibits the reaction [SCD1 gene mutant form inhibits the reaction [Fructose results in increased expression of SREBF1 mRNA]]; Triolein inhibits the reaction [SCD1 gene mutant form inhibits the reaction [Fructose results in increased expression of SREBF1 protein]]
[Fructose co-treated with Copper deficiency] results in decreased expression of SCD1 mRNA; Atorvastatin inhibits the reaction [Fructose results in increased expression of SCD1 mRNA]; gadolinium chloride promotes the reaction [[Fructose co-treated with Copper deficiency] results in decreased expression of SCD1 mRNA]; Tea inhibits the reaction [Fructose results in increased expression of SCD1 mRNA]
Fructose results in increased expression of SCD1 mRNA; Fructose results in increased expression of SCD1 protein
SCD1 affects the susceptibility to Fructose
CTD PMID:15066988 PMID:19053045 PMID:19193814 PMID:21122807 PMID:22698815 PMID:25813056 PMID:28123933 NCBI chr19:44,394,450...44,407,709
Ensembl chr19:44,394,455...44,407,879
JBrowse link
G Scd2 stearoyl-Coenzyme A desaturase 2 increases expression ISO Fructose results in increased expression of SCD mRNA; Fructose results in increased expression of SCD1 mRNA CTD PMID:7961698 PMID:18063403 NCBI chr19:44,293,676...44,306,864
Ensembl chr19:44,293,674...44,306,864
JBrowse link
G Serpine1 serine (or cysteine) peptidase inhibitor, clade E, member 1 increases secretion
increases expression
multiple interactions
ISO Fructose results in increased secretion of SERPINE1 protein
Fructose results in increased expression of SERPINE1 mRNA; Fructose results in increased expression of SERPINE1 protein
Atorvastatin inhibits the reaction [Fructose results in increased expression of SERPINE1 mRNA]; Metformin inhibits the reaction [Fructose results in increased expression of SERPINE1 protein]; Progesterone inhibits the reaction [Fructose results in increased expression of SERPINE1 mRNA]; Progesterone inhibits the reaction [Fructose results in increased expression of SERPINE1 protein]; Resveratrol inhibits the reaction [Fructose results in increased expression of SERPINE1 protein]
CTD PMID:19165636 PMID:21122807 PMID:23016136 PMID:25108154 NCBI chr 5:137,061,504...137,072,272
Ensembl chr 5:137,061,504...137,072,268
JBrowse link
G Sgk1 serum/glucocorticoid regulated kinase 1 increases expression
multiple interactions
EXP Fructose results in increased expression of SGK1 mRNA
SGK1 gene affects the susceptibility to [Fructose co-treated with Sodium Chloride, Dietary]
CTD PMID:16284089 NCBI chr10:21,882,184...21,999,903
Ensembl chr10:21,882,184...21,999,903
JBrowse link
G Shbg sex hormone binding globulin multiple interactions
decreases expression
ISO Cerulenin inhibits the reaction [Fructose results in decreased expression of SHBG protein]; Fructose affects the reaction [NR2F1 protein binds to SHBG promoter] CTD PMID:17992261 NCBI chr11:69,610,282...69,618,026
Ensembl chr11:69,614,804...69,617,905
JBrowse link
G Sirt1 sirtuin 1 multiple interactions
decreases expression
increases expression
EXP
ISO
SIRT1 protein affects the reaction [Fructose results in increased expression of MYH6 mRNA]
[Fructose co-treated with Palmitic Acid] results in decreased expression of SIRT1 protein; Fenofibrate inhibits the reaction [[Fructose co-treated with Palmitic Acid] results in decreased expression of SIRT1 protein]
Fructose results in decreased expression of SIRT1 mRNA; Fructose results in decreased expression of SIRT1 protein
[6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in decreased activity of SIRT1 protein] inhibits the reaction [Fructose results in increased abundance of Cholesterol]; [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in decreased activity of SIRT1 protein] inhibits the reaction [Fructose results in increased abundance of Glucose]; [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in decreased activity of SIRT1 protein] inhibits the reaction [Fructose results in increased expression of ACACA mRNA]; [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in decreased activity of SIRT1 protein] inhibits the reaction [Fructose results in increased expression of HMGCR mRNA]; [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in decreased activity of SIRT1 protein] which results in decreased susceptibility to Fructose; [Niacinamide results in decreased activity of SIRT1 protein] inhibits the reaction [Fructose results in increased abundance of Cholesterol]; [Niacinamide results in decreased activity of SIRT1 protein] inhibits the reaction [Fructose results in increased abundance of Glucose]; [Niacinamide results in decreased activity of SIRT1 protein] inhibits the reaction [Fructose results in increased expression of ACACA mRNA]; [Niacinamide results in decreased activity of SIRT1 protein] inhibits the reaction [Fructose results in increased expression of HMGCR mRNA]; [Niacinamide results in decreased activity of SIRT1 protein] which results in decreased susceptibility to Fructose; Fructose results in increased expression of and results in increased activity of SIRT1 protein; Metformin inhibits the reaction [Fructose results in decreased expression of SIRT1 protein]; resveratrol inhibits the reaction [Fructose results in decreased expression of SIRT1 mRNA]; resveratrol inhibits the reaction [Fructose results in decreased expression of SIRT1 protein]
Fructose results in increased expression of SIRT1 protein
CTD PMID:18192211 PMID:21212096 PMID:25108154 PMID:26488877 PMID:32730863 NCBI chr10:63,319,005...63,339,035
Ensembl chr10:63,319,005...63,381,704
JBrowse link
G Sis sucrase isomaltase (alpha-glucosidase) increases expression EXP
ISO
Fructose results in increased expression of SI mRNA CTD PMID:10222385 PMID:11242478 PMID:17786952 NCBI chr 3:72,888,557...72,967,863
Ensembl chr 3:72,888,557...72,967,863
JBrowse link
G Slc22a1 solute carrier family 22 (organic cation transporter), member 1 decreases expression
multiple interactions
ISO Fructose results in decreased expression of SLC22A1 mRNA; Fructose results in decreased expression of SLC22A1 protein
Allopurinol inhibits the reaction [Fructose results in decreased expression of SLC22A1 mRNA]; Allopurinol inhibits the reaction [Fructose results in decreased expression of SLC22A1 protein]; Quercetin inhibits the reaction [Fructose results in decreased expression of SLC22A1 mRNA]; Quercetin inhibits the reaction [Fructose results in decreased expression of SLC22A1 protein]; Rutin inhibits the reaction [Fructose results in decreased expression of SLC22A1 mRNA]; Rutin inhibits the reaction [Fructose results in decreased expression of SLC22A1 protein]
CTD PMID:19605544 NCBI chr17:12,648,874...12,675,838
Ensembl chr17:12,648,869...12,675,829
JBrowse link
G Slc22a12 solute carrier family 22 (organic anion/cation transporter), member 12 multiple interactions
increases expression
ISO Allopurinol inhibits the reaction [Fructose results in increased expression of SLC22A12 mRNA]; Allopurinol inhibits the reaction [Fructose results in increased expression of SLC22A12 protein]; Quercetin inhibits the reaction [Fructose results in increased expression of SLC22A12 mRNA]; Quercetin inhibits the reaction [Fructose results in increased expression of SLC22A12 protein]; Rutin inhibits the reaction [Fructose results in increased expression of SLC22A12 mRNA]; Rutin inhibits the reaction [Fructose results in increased expression of SLC22A12 protein]
Fructose results in increased expression of SLC22A12 mRNA; Fructose results in increased expression of SLC22A12 protein
CTD PMID:19605544 NCBI chr19:6,535,854...6,543,070
Ensembl chr19:6,535,845...6,543,032
JBrowse link
G Slc22a2 solute carrier family 22 (organic cation transporter), member 2 decreases expression
multiple interactions
ISO Fructose results in decreased expression of SLC22A2 mRNA; Fructose results in decreased expression of SLC22A2 protein
Allopurinol inhibits the reaction [Fructose results in decreased expression of SLC22A2 mRNA]; Allopurinol inhibits the reaction [Fructose results in decreased expression of SLC22A2 protein]; Quercetin inhibits the reaction [Fructose results in decreased expression of SLC22A2 mRNA]; Quercetin inhibits the reaction [Fructose results in decreased expression of SLC22A2 protein]; Rutin inhibits the reaction [Fructose results in decreased expression of SLC22A2 mRNA]; Rutin inhibits the reaction [Fructose results in decreased expression of SLC22A2 protein]
CTD PMID:19605544 NCBI chr17:12,584,189...12,628,489
Ensembl chr17:12,584,132...12,628,488
JBrowse link
G Slc22a5 solute carrier family 22 (organic cation transporter), member 5 decreases expression
multiple interactions
ISO Fructose results in decreased expression of SLC22A5 protein
Allopurinol inhibits the reaction [Fructose results in decreased expression of SLC22A5 protein]; Quercetin inhibits the reaction [Fructose results in decreased expression of SLC22A5 protein]
CTD PMID:22426011 NCBI chr11:53,864,542...53,891,796
Ensembl chr11:53,864,542...53,891,660
JBrowse link
G Slc22a6 solute carrier family 22 (organic anion transporter), member 6 multiple interactions
decreases expression
ISO Allopurinol inhibits the reaction [Fructose results in decreased expression of SLC22A6 mRNA]; Allopurinol inhibits the reaction [Fructose results in decreased expression of SLC22A6 protein]; Quercetin inhibits the reaction [Fructose results in decreased expression of SLC22A6 mRNA]; Quercetin inhibits the reaction [Fructose results in decreased expression of SLC22A6 protein]; Rutin inhibits the reaction [Fructose results in decreased expression of SLC22A6 mRNA]; Rutin inhibits the reaction [Fructose results in decreased expression of SLC22A6 protein]
Fructose results in decreased expression of SLC22A6 mRNA; Fructose results in decreased expression of SLC22A6 protein
CTD PMID:19605544 NCBI chr19:8,617,996...8,628,299
Ensembl chr19:8,618,039...8,628,299
JBrowse link
G Slc25a5 solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 5 multiple interactions ISO [Fructose co-treated with bisphenol A] results in decreased expression of SLC25A5 protein CTD PMID:26930160 NCBI chr  X:36,795,597...36,798,808
Ensembl chr  X:36,795,651...36,798,807
JBrowse link
G Slc27a2 solute carrier family 27 (fatty acid transporter), member 2 decreases expression EXP Fructose results in decreased expression of SLC27A2 protein CTD PMID:28257781 NCBI chr 2:126,553,024...126,588,243
Ensembl chr 2:126,552,407...126,588,243
JBrowse link
G Slc2a2 solute carrier family 2 (facilitated glucose transporter), member 2 multiple interactions
increases expression
increases transport
ISO
EXP
Fructose inhibits the reaction [SLC2A2 protein results in increased transport of Deoxyglucose]; Glucose inhibits the reaction [SLC2A2 protein results in increased transport of Fructose]; Maltose inhibits the reaction [SLC2A2 protein results in increased transport of Fructose]
Fructose results in increased expression of SLC2A2 mRNA
Dactinomycin inhibits the reaction [Fructose results in increased expression of SLC2A2 mRNA]
Fructose results in increased expression of and affects the localization of SLC2A2 protein
CTD PMID:1727734 PMID:8457197 PMID:10222385 PMID:12787936 PMID:12937289 PMID:17710649 PMID:17786952 NCBI chr 3:28,697,903...28,728,361
Ensembl chr 3:28,697,903...28,731,359
JBrowse link
G Slc2a4 solute carrier family 2 (facilitated glucose transporter), member 4 decreases expression
multiple interactions
increases expression
ISO Fructose results in decreased expression of SLC2A4 mRNA
[Dietary Fats co-treated with Fructose] results in decreased expression of SLC2A4 protein; Carnitine inhibits the reaction [[Dietary Fats co-treated with Fructose] results in decreased expression of SLC2A4 protein]; Fatty Acids, Omega-3 inhibits the reaction [[Dietary Fats co-treated with Fructose] results in decreased expression of SLC2A4 protein]; Metformin inhibits the reaction [[Dietary Fats co-treated with Fructose] results in decreased expression of SLC2A4 protein]
Fructose results in increased expression of SLC2A4 mRNA
CTD PMID:15111496 PMID:18063403 PMID:30256492 NCBI chr11:69,942,286...69,948,216
Ensembl chr11:69,942,539...69,948,188
JBrowse link
G Slc2a5 solute carrier family 2 (facilitated glucose transporter), member 5 multiple interactions
increases activity
increases expression
increases transport
increases uptake
affects expression
ISO
EXP
[Fructose results in increased abundance of Cyclic AMP] which results in increased stability of SLC2A5 mRNA; Colforsin promotes the reaction [Fructose results in increased expression of SLC2A5 mRNA]; Fructose promotes the reaction [PAIP2 protein binds to SLC2A5 3' UTR]
Fructose results in increased activity of SLC2A5 protein
SLC2A5 protein results in increased transport of Fructose
Fructose results in increased expression of SLC2A5 mRNA; Fructose results in increased expression of SLC2A5 protein
SLC2A5 protein results in increased uptake of Fructose
Fructose affects the expression of SLC2A5 mRNA
Fructose analog results in increased expression of SLC2A5 mRNA; Fructose results in increased expression of SLC2A5 mRNA; Fructose results in increased expression of SLC2A5 protein
1-((1-O-octadecyl-2-O-methylglycero)phospho)-3-deoxy-myo-inositol inhibits the reaction [Fructose results in increased expression of and results in increased activity of SLC2A5 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Fructose results in increased expression of and results in increased activity of SLC2A5 protein]; [[Colforsin results in increased abundance of Cyclic AMP] which results in increased expression of SLC2A5 protein] which results in increased uptake of Fructose; [Triiodothyronine co-treated with Fructose] results in increased expression of SLC2A5 mRNA; Cycloheximide inhibits the reaction [Fructose promotes the reaction [SLC2A5 protein results in increased uptake of Fructose]]; Dactinomycin inhibits the reaction [Fructose promotes the reaction [SLC2A5 protein results in increased uptake of Fructose]]; Dactinomycin inhibits the reaction [Fructose results in increased expression of SLC2A5 mRNA]; Dexamethasone promotes the reaction [Fructose results in increased activity of SLC2A5 protein]; Dexamethasone promotes the reaction [Fructose results in increased expression of SLC2A5 mRNA]; Fructose analog results in increased activity of [SLC2A5 protein results in increased uptake of Fructose]; Fructose promotes the reaction [SLC2A5 protein results in increased transport of Fructose]; Fructose promotes the reaction [SLC2A5 protein results in increased uptake of Fructose]; Fructose results in increased expression of and results in increased activity of SLC2A5 protein; Mifepristone inhibits the reaction [Dexamethasone promotes the reaction [Fructose results in increased activity of SLC2A5 protein]]; Mifepristone inhibits the reaction [Dexamethasone promotes the reaction [Fructose results in increased expression of SLC2A5 mRNA]]; Vanadates inhibits the reaction [Fructose results in increased activity of SLC2A5 protein]; Vanadates inhibits the reaction [Fructose results in increased expression of SLC2A5 mRNA]; wortmannin inhibits the reaction [Fructose results in increased expression of and results in increased activity of SLC2A5 protein]
lactisole inhibits the reaction [Fructose results in increased expression of SLC2A5 mRNA]
CTD PMID:1634504 PMID:8037665 PMID:8048533 PMID:8404647 PMID:8554516 PMID:9078534 PMID:9124564 PMID:9486174 PMID:9606981 PMID:10222385 PMID:10554124 PMID:11123204 PMID:11242478 PMID:11518678 PMID:12031501 PMID:12820898 PMID:12937289 PMID:15150374 PMID:15226456 PMID:15457374 PMID:15691865 PMID:16581195 PMID:16920846 PMID:16960373 PMID:17485832 PMID:17710649 PMID:17786952 PMID:18400728 PMID:18556366 PMID:19907007 NCBI chr 4:150,119,344...150,144,168
Ensembl chr 4:150,119,283...150,144,169
JBrowse link
G Slc2a7 solute carrier family 2 (facilitated glucose transporter), member 7 increases transport ISO SLC2A7 protein results in increased transport of Fructose CTD PMID:15033637 PMID:17710649 NCBI chr 4:150,148,834...150,169,042
Ensembl chr 4:150,148,972...150,168,482
JBrowse link
G Slc2a9 solute carrier family 2 (facilitated glucose transporter), member 9 increases transport
increases expression
multiple interactions
ISO SLC2A9 protein results in increased transport of Fructose
Fructose results in increased expression of SLC2A9 mRNA SNP; Fructose results in increased expression of SLC2A9 protein SNP
Allopurinol inhibits the reaction [Fructose results in increased expression of SLC2A9 mRNA SNP]; Allopurinol inhibits the reaction [Fructose results in increased expression of SLC2A9 protein SNP]; Quercetin inhibits the reaction [Fructose results in increased expression of SLC2A9 mRNA SNP]; Quercetin inhibits the reaction [Fructose results in increased expression of SLC2A9 protein SNP]; Rutin inhibits the reaction [Fructose results in increased expression of SLC2A9 mRNA SNP]; Rutin inhibits the reaction [Fructose results in increased expression of SLC2A9 protein SNP]
Fructose promotes the reaction [SLC2A9 protein alternative form results in increased transport of Uric Acid]
CTD PMID:17710649 PMID:18842065 PMID:19605544 NCBI chr 5:38,349,272...38,503,147
Ensembl chr 5:38,349,273...38,503,143
JBrowse link
G Slc31a1 solute carrier family 31, member 1 multiple interactions ISO Fructose inhibits the reaction [Copper deficiency results in increased expression of SLC31A1 protein] CTD PMID:21781943 NCBI chr 4:62,360,583...62,391,769
Ensembl chr 4:62,360,727...62,391,769
JBrowse link
G Slc34a2 solute carrier family 34 (sodium phosphate), member 2 decreases expression
multiple interactions
affects expression
ISO Fructose results in decreased expression of SLC34A2 mRNA
tungstate promotes the reaction [Fructose results in decreased expression of SLC34A2 mRNA]; Vanadates promotes the reaction [Fructose results in decreased expression of SLC34A2 mRNA]
Fructose affects the expression of SLC34A2 mRNA
CTD PMID:15150374 PMID:18400728 NCBI chr 5:53,049,353...53,071,664
Ensembl chr 5:53,038,081...53,071,664
JBrowse link
G Slc37a4 solute carrier family 37 (glucose-6-phosphate transporter), member 4 increases expression ISO Fructose results in increased expression of SLC37A4 mRNA CTD PMID:16920846 NCBI chr 9:44,396,946...44,402,966
Ensembl chr 9:44,396,852...44,402,968
JBrowse link
G Slc46a1 solute carrier family 46, member 1 multiple interactions ISO [Folic Acid affects the susceptibility to Fructose] which affects the expression of SLC46A1 mRNA CTD PMID:31612177 NCBI chr11:78,465,701...78,471,945
Ensembl chr11:78,465,697...78,472,059
JBrowse link
G Slc5a1 solute carrier family 5 (sodium/glucose cotransporter), member 1 multiple interactions
increases expression
EXP
ISO
lactisole inhibits the reaction [Fructose results in increased expression of SLC5A1 mRNA]
Fructose results in increased expression of SLC5A1 mRNA; Fructose results in increased expression of SLC5A1 protein
CTD PMID:8048533 PMID:10222385 PMID:11242478 PMID:12937289 PMID:17786952 NCBI chr 5:33,104,219...33,162,699
Ensembl chr 5:33,104,219...33,162,870
JBrowse link
G Slc8a1 solute carrier family 8 (sodium/calcium exchanger), member 1 multiple interactions EXP [Fructose co-treated with Dietary Fats] results in decreased expression of SLC8A1 mRNA; troxerutin inhibits the reaction [[Fructose co-treated with Dietary Fats] results in decreased expression of SLC8A1 mRNA] CTD PMID:28916335 NCBI chr17:81,373,105...81,738,387
Ensembl chr17:81,373,105...81,738,377
JBrowse link
G Soat2 sterol O-acyltransferase 2 decreases expression ISO Fructose results in decreased expression of SOAT2 mRNA CTD PMID:19193814 NCBI chr15:102,150,415...102,163,469
Ensembl chr15:102,150,526...102,163,469
JBrowse link
G Socs3 suppressor of cytokine signaling 3 increases expression
multiple interactions
ISO Fructose results in increased expression of SOCS3 mRNA; Fructose results in increased expression of SOCS3 protein
[Fenofibrate co-treated with resveratrol] inhibits the reaction [Fructose results in increased expression of SOCS3 mRNA]; Fenofibrate inhibits the reaction [Fructose results in increased expression of SOCS3 mRNA]; Quercetin inhibits the reaction [Fructose results in increased expression of SOCS3 protein]; resveratrol inhibits the reaction [Fructose results in increased expression of SOCS3 mRNA]; Rutin inhibits the reaction [Fructose results in increased expression of SOCS3 protein]
CTD PMID:21122807 PMID:22426011 PMID:23533474 PMID:26973390 NCBI chr11:117,966,079...117,970,336
Ensembl chr11:117,966,079...117,970,047
JBrowse link
G Sod1 superoxide dismutase 1, soluble affects binding
decreases expression
multiple interactions
decreases activity
increases activity
ISO Fructose binds to SOD1 protein mutant form
Fructose results in decreased expression of SOD1 mRNA; Fructose results in decreased expression of SOD1 protein
[Fructose co-treated with Copper deficiency] results in decreased expression of SOD1 protein
Fructose results in decreased activity of SOD1 protein
Fructose results in increased activity of SOD1 protein
Fructose promotes the reaction [SOD1 protein mutant form results in increased chemical synthesis of Hydrogen Peroxide]
CTD PMID:11817707 PMID:12626432 PMID:16815490 PMID:20470786 PMID:21781943 NCBI chr16:90,220,762...90,226,333
Ensembl chr16:90,220,754...90,226,329
JBrowse link
G Sord sorbitol dehydrogenase multiple interactions
increases glycation
ISO [Fructose results in increased glycation of SORD protein] which results in decreased activity of SORD protein
[SORD protein results in increased metabolism of Sorbitol] which results in increased abundance of Fructose
CTD PMID:8761460 PMID:32367058 NCBI chr 2:122,234,839...122,265,337
Ensembl chr 2:122,234,749...122,265,340
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions
increases expression
affects localization
affects response to substance
EXP
ISO
Phenylbutyrates inhibits the reaction [Fructose affects the localization of SREBF1 protein alternative form]; Phenylbutyrates inhibits the reaction [Fructose results in increased expression of SREBF1 mRNA]; SCD1 affects the reaction [Fructose results in increased expression of SREBF1 protein]; SCD1 gene mutant form inhibits the reaction [Fructose results in increased expression of SREBF1 mRNA]; SCD1 gene mutant form inhibits the reaction [Fructose results in increased expression of SREBF1 protein]; Triolein inhibits the reaction [SCD1 gene mutant form inhibits the reaction [Fructose results in increased expression of SREBF1 mRNA]]; Triolein inhibits the reaction [SCD1 gene mutant form inhibits the reaction [Fructose results in increased expression of SREBF1 protein]]
Fructose results in increased expression of SREBF1 mRNA; Fructose results in increased expression of SREBF1 protein
[Atorvastatin co-treated with dapagliflozin] inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of SREBF1 protein]; [Fenofibrate co-treated with Resveratrol] inhibits the reaction [Fructose results in increased expression of SREBF1 mRNA]; [Fructose co-treated with Copper deficiency] results in increased expression of SREBF1 protein; [Fructose co-treated with Dietary Fats] results in increased expression of SREBF1 protein; Atorvastatin inhibits the reaction [Fructose results in increased activity of SREBF1 protein]; dapagliflozin inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of SREBF1 protein]; Fructose promotes the reaction [RBMX protein binds to SREBF1 promoter]; Fructose results in increased expression of and results in increased activity of SREBF1 protein; gadolinium chloride inhibits the reaction [[Fructose co-treated with Copper deficiency] results in increased expression of SREBF1 protein]; Resveratrol inhibits the reaction [Fructose results in increased expression of SREBF1 mRNA]; Rosiglitazone inhibits the reaction [Fructose results in increased expression of SREBF1 mRNA]; Tea inhibits the reaction [Fructose results in increased expression of SREBF1 mRNA]
SREBF1 promoter SNP affects the susceptibility to Fructose
CTD PMID:10913129 PMID:11934685 PMID:15066988 PMID:15123654 PMID:17188681 PMID:18346472 PMID:19053045 PMID:19193814 PMID:19196556 PMID:19799862 PMID:22698815 PMID:25813056 PMID:26973390 PMID:32259528 NCBI chr11:60,199,084...60,224,186
Ensembl chr11:60,199,089...60,222,581
JBrowse link
G Stat3 signal transducer and activator of transcription 3 increases phosphorylation
decreases phosphorylation
multiple interactions
ISO Fructose results in increased phosphorylation of STAT3 protein
Fructose results in decreased phosphorylation of STAT3 protein
Quercetin inhibits the reaction [Fructose results in decreased phosphorylation of STAT3 protein]; Quercetin inhibits the reaction [Fructose results in increased phosphorylation of STAT3 protein]; Rutin inhibits the reaction [Fructose results in increased phosphorylation of STAT3 protein]
CTD PMID:22426011 PMID:23533474 NCBI chr11:100,886,806...100,939,594
Ensembl chr11:100,885,098...100,939,540
JBrowse link
G Steap4 STEAP family member 4 multiple interactions ISO [Dietary Fats co-treated with Fructose] results in increased expression of STEAP4 mRNA CTD PMID:19632207 NCBI chr 5:7,960,472...7,982,213
Ensembl chr 5:7,960,457...7,982,213
JBrowse link
G Tfam transcription factor A, mitochondrial increases expression ISO Fructose results in increased expression of TFAM protein CTD PMID:11934685 NCBI chr10:71,225,468...71,238,328
Ensembl chr10:71,225,464...71,238,280
JBrowse link
G Tgfb1 transforming growth factor, beta 1 decreases expression
multiple interactions
increases expression
ISO
EXP
Fructose results in decreased expression of TGFB1 mRNA
[FGF21 gene mutant form results in increased susceptibility to Fructose] which results in increased expression of TGFB1 mRNA
Fructose results in increased expression of TGFB1 mRNA; Fructose results in increased expression of TGFB1 protein
[Fenofibrate co-treated with Resveratrol] inhibits the reaction [Fructose results in increased expression of TGFB1 mRNA]; [Streptozocin co-treated with Fructose] results in increased expression of and results in increased secretion of TGFB1 protein; betanin inhibits the reaction [Fructose results in increased expression of TGFB1 protein]; dapagliflozin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of and results in increased secretion of TGFB1 protein]; dapagliflozin promotes the reaction [Metformin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of and results in increased secretion of TGFB1 protein]]; Fenofibrate inhibits the reaction [Fructose results in increased expression of TGFB1 mRNA]; galangin inhibits the reaction [Fructose results in increased expression of TGFB1 protein]; Genistein inhibits the reaction [Fructose results in increased expression of TGFB1 protein]; Metformin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of and results in increased secretion of TGFB1 protein]; Resveratrol inhibits the reaction [Fructose results in increased expression of TGFB1 mRNA]
CTD PMID:15150374 PMID:21704028 PMID:21708140 PMID:25559852 PMID:26973390 PMID:28123933 PMID:30551545 NCBI chr 7:25,687,002...25,705,077
Ensembl chr 7:25,687,002...25,705,077
JBrowse link
G Tgfb2 transforming growth factor, beta 2 multiple interactions EXP [FGF21 gene mutant form results in increased susceptibility to Fructose] which results in increased expression of TGFB2 mRNA CTD PMID:28123933 NCBI chr 1:186,622,787...186,709,697
Ensembl chr 1:186,622,792...186,705,989
JBrowse link
G Th tyrosine hydroxylase increases expression EXP Fructose results in increased expression of TH mRNA CTD PMID:16843071 NCBI chr 7:142,892,779...142,899,995
Ensembl chr 7:142,892,752...142,931,128
JBrowse link
G Thrsp thyroid hormone responsive multiple interactions ISO Fructose inhibits the reaction [Streptozocin results in decreased expression of THRSP mRNA] CTD PMID:2177838 NCBI chr 7:97,412,933...97,417,550
Ensembl chr 7:97,412,938...97,417,730
JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions
increases expression
ISO
EXP
[gadolinium chloride co-treated with Fructose co-treated with Copper deficiency] results in decreased expression of TLR4 mRNA
Fructose results in increased expression of TLR4 protein
[Fructose co-treated with Ethanol] results in increased expression of TLR4 mRNA
CTD PMID:25813056 PMID:26858005 PMID:31672515 NCBI chr 4:66,827,551...66,846,581
Ensembl chr 4:66,827,584...66,930,284
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases secretion
increases expression
ISO
EXP
2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [caryophyllene inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of TNF protein]]; [Dietary Fats co-treated with Fructose] results in increased expression of TNF protein; [Fenofibrate co-treated with Resveratrol] inhibits the reaction [Fructose results in increased expression of and results in increased secretion of TNF protein]; [gadolinium chloride co-treated with Fructose co-treated with Copper deficiency] results in decreased expression of TNF mRNA; [Particulate Matter co-treated with Ozone] promotes the reaction [Fructose results in increased expression of TNF mRNA]; [Streptozocin co-treated with Fructose] results in increased expression of and results in increased secretion of TNF protein; Allopurinol inhibits the reaction [Fructose results in increased expression of TNF protein]; caffeic acid phenethyl ester inhibits the reaction [Fructose results in increased expression of TNF protein]; caryophyllene inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of TNF protein]; Curcumin inhibits the reaction [Fructose results in increased expression of TNF protein]; dapagliflozin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of and results in increased secretion of TNF protein]; dapagliflozin promotes the reaction [Metformin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of and results in increased secretion of TNF protein]]; Fenofibrate inhibits the reaction [Fructose results in increased expression of and results in increased secretion of TNF protein]; Fructose inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of TNF protein]; Fructose results in increased expression of and results in increased secretion of TNF protein; galangin inhibits the reaction [Fructose results in increased expression of TNF mRNA]; galangin inhibits the reaction [Fructose results in increased expression of TNF protein]; Genistein inhibits the reaction [Fructose results in increased expression of TNF protein]; geraniol inhibits the reaction [Fructose results in increased secretion of TNF protein]; iodopravadoline inhibits the reaction [caryophyllene inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of TNF protein]]; Metformin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of and results in increased secretion of TNF protein]; Metformin inhibits the reaction [Fructose results in increased expression of TNF protein]; Ozone promotes the reaction [Fructose results in increased expression of TNF mRNA]; Particulate Matter promotes the reaction [Fructose results in increased expression of TNF mRNA]; Pioglitazone inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of TNF protein]; Pioglitazone inhibits the reaction [Fructose results in increased secretion of TNF protein]; Quercetin inhibits the reaction [Fructose results in increased expression of TNF protein]; Resveratrol inhibits the reaction [Fructose results in increased expression of and results in increased secretion of TNF protein]; Resveratrol inhibits the reaction [Fructose results in increased expression of TNF protein]; Rutin inhibits the reaction [Fructose results in increased expression of TNF protein]; tributylhexadecylphosphonium bromide inhibits the reaction [Fructose results in increased expression of TNF protein]
Fructose promotes the reaction [Ethanol results in increased expression of TNF mRNA]
Fructose results in increased expression of TNF mRNA; Fructose results in increased expression of TNF protein
CTD PMID:10090849 PMID:21704028 PMID:21708140 PMID:22426011 PMID:23968387 PMID:24508943 PMID:25108154 PMID:25679220 PMID:25813056 PMID:26358169 PMID:26713546 PMID:26858005 PMID:26973390 PMID:27531227 PMID:28257781 PMID:30343038 PMID:30551545 PMID:31672515 NCBI chr17:35,199,367...35,202,007
Ensembl chr17:35,199,381...35,202,007
JBrowse link
G Traf6 TNF receptor-associated factor 6 multiple interactions EXP Fructose inhibits the reaction [Ethanol results in increased expression of TRAF6 protein]; Fructose promotes the reaction [Ethanol results in increased expression of TRAF6 mRNA] CTD PMID:26858005 NCBI chr 2:101,678,420...101,701,668
Ensembl chr 2:101,678,429...101,701,669
JBrowse link
G Trap1 TNF receptor-associated protein 1 multiple interactions
decreases expression
ISO [Fructose co-treated with bisphenol A] results in increased expression of TRAP1 protein
Fructose results in decreased expression of TRAP1 protein
CTD PMID:26930160 NCBI chr16:4,039,971...4,077,840
Ensembl chr16:4,039,971...4,077,827
JBrowse link
G Trib3 tribbles pseudokinase 3 increases expression
multiple interactions
ISO
EXP
Fructose results in increased expression of TRIB3 mRNA
Phenylbutyrates inhibits the reaction [Fructose results in increased expression of TRIB3 mRNA]
CTD PMID:18497449 PMID:22698815 NCBI chr 2:152,337,425...152,344,060
Ensembl chr 2:152,337,422...152,344,032
JBrowse link
G Ttr transthyretin multiple interactions ISO [Fructose co-treated with bisphenol A] results in increased expression of TTR protein CTD PMID:26930160 NCBI chr18:20,664,209...20,674,326
Ensembl chr18:20,665,280...20,674,321
JBrowse link
G Txnip thioredoxin interacting protein increases expression
multiple interactions
ISO Fructose results in increased expression of TXNIP protein
Allopurinol inhibits the reaction [Fructose results in increased expression of TXNIP protein]; Quercetin inhibits the reaction [Fructose results in increased expression of TXNIP protein]
CTD PMID:24491314 NCBI chr 3:96,557,957...96,561,857
Ensembl chr 3:96,557,957...96,561,883
JBrowse link
G Ucp1 uncoupling protein 1 (mitochondrial, proton carrier) multiple interactions
decreases expression
ISO Fructose promotes the reaction [[Ozone co-treated with Particulate Matter] results in decreased expression of UCP1 mRNA]; Fructose promotes the reaction [Ozone results in decreased expression of UCP1 mRNA]; Fructose promotes the reaction [Particulate Matter results in decreased expression of UCP1 mRNA]
Fructose results in decreased expression of UCP1 mRNA
CTD PMID:23968387 NCBI chr 8:83,290,348...83,298,456
Ensembl chr 8:83,290,352...83,298,452
JBrowse link
G Ucp3 uncoupling protein 3 (mitochondrial, proton carrier) increases expression ISO Fructose results in increased expression of UCP3 protein CTD PMID:11934685 NCBI chr 7:100,472,991...100,486,432
Ensembl chr 7:100,472,990...100,486,432
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 increases expression
multiple interactions
ISO Fructose results in increased expression of VCAM1 mRNA
2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [caryophyllene inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of VCAM1 protein]]; [Dietary Fats co-treated with Fructose] results in increased expression of VCAM1 protein; caryophyllene inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of VCAM1 protein]; iodopravadoline inhibits the reaction [caryophyllene inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of VCAM1 protein]]; Pioglitazone inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of VCAM1 protein]
CTD PMID:17587757 PMID:30343038 PMID:31655124 NCBI chr 3:116,110,020...116,129,688
Ensembl chr 3:116,109,949...116,129,688
JBrowse link
G Vcl vinculin multiple interactions
decreases expression
ISO [Fructose co-treated with bisphenol A] results in decreased expression of VCL protein
Fructose results in decreased expression of VCL protein
CTD PMID:26930160 NCBI chr14:20,929,383...21,033,676
Ensembl chr14:20,929,398...21,033,676
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO [bisphenol A co-treated with Fructose] results in increased expression of VEGFA mRNA CTD PMID:27622962 NCBI chr17:46,016,993...46,032,377
Ensembl chr17:46,016,993...46,032,369
JBrowse link
G Vldlr very low density lipoprotein receptor multiple interactions EXP [PPARD mRNA results in decreased susceptibility to Fructose] which results in decreased expression of VLDLR mRNA; Fructose inhibits the reaction [PPARD mRNA results in decreased expression of VLDLR mRNA]; Fructose promotes the reaction [PPARD gene mutant form results in increased expression of VLDLR mRNA]; Fructose promotes the reaction [PPARD gene mutant form results in increased expression of VLDLR protein] CTD PMID:29289645 NCBI chr19:27,216,480...27,254,231
Ensembl chr19:27,216,484...27,254,231
JBrowse link
G Vnn1 vanin 1 multiple interactions ISO [Streptozocin co-treated with Fructose] results in increased expression of VNN1 mRNA; dapagliflozin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of VNN1 mRNA]; Metformin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of VNN1 mRNA] CTD PMID:30551545 NCBI chr10:23,894,688...23,905,344
Ensembl chr10:23,894,688...23,905,343
JBrowse link
G Xbp1 X-box binding protein 1 affects localization EXP Fructose affects the localization of XBP1 protein CTD PMID:22698815 NCBI chr11:5,520,641...5,525,993
Ensembl chr11:5,520,659...5,525,893
JBrowse link
G Xdh xanthine dehydrogenase multiple interactions
increases activity
ISO Fructose promotes the reaction [XDH protein results in increased chemical synthesis of Uric Acid]; XDH protein promotes the reaction [Fructose results in increased abundance of Reactive Oxygen Species]
Glutamine inhibits the reaction [Fructose results in increased activity of XDH protein]
CTD PMID:19158351 PMID:31233715 NCBI chr17:73,883,895...73,950,397
Ensembl chr17:73,883,895...73,950,196
JBrowse link
G Ybx3 Y box protein 3 multiple interactions ISO [Fructose co-treated with bisphenol A] results in increased expression of YBX3 protein CTD PMID:26930160 NCBI chr 6:131,364,858...131,388,450
Ensembl chr 6:131,364,855...131,388,476
JBrowse link
keto-D-fructose 1,6-bisphosphate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gapdh glyceraldehyde-3-phosphate dehydrogenase multiple interactions ISO [GAPDH protein co-treated with fructose-1,6-diphosphate co-treated with NAD] results in increased chemical synthesis of sodium arsenite; [GAPDH protein co-treated with fructose-1,6-diphosphate co-treated with NAD] results in increased reduction of sodium arsenate analog; heptelidic acid inhibits the reaction [[GAPDH protein co-treated with fructose-1,6-diphosphate co-treated with NAD] results in increased reduction of sodium arsenate analog] CTD PMID:15788719 NCBI chr 6:125,161,852...125,166,467
Ensembl chr 6:125,161,715...125,166,467
JBrowse link
G Idh2 isocitrate dehydrogenase 2 (NADP+), mitochondrial increases abundance
multiple interactions
EXP IDH2 protein mutant form results in increased abundance of fructose-1,6-diphosphate
Triazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of fructose-1,6-diphosphate]
CTD PMID:27469509 NCBI chr 7:80,094,845...80,118,608
Ensembl chr 7:80,094,846...80,115,392
JBrowse link
G Mapk1 mitogen-activated protein kinase 1 multiple interactions EXP fructose-1,6-diphosphate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein] CTD PMID:22227475 NCBI chr16:16,983,382...17,047,453
Ensembl chr16:16,983,382...17,047,453
JBrowse link
G Mapk3 mitogen-activated protein kinase 3 multiple interactions EXP fructose-1,6-diphosphate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein] CTD PMID:22227475 NCBI chr 7:126,759,626...126,765,816
Ensembl chr 7:126,759,601...126,765,819
JBrowse link
G Nos2 nitric oxide synthase 2, inducible multiple interactions
decreases degradation
EXP fructose-1,6-diphosphate inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; fructose-1,6-diphosphate inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]
fructose-1,6-diphosphate results in decreased degradation of NOS2 mRNA
CTD PMID:22227475 NCBI chr11:78,920,787...78,960,226
Ensembl chr11:78,920,787...78,960,254
JBrowse link
psicose term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl2 chemokine (C-C motif) ligand 2 multiple interactions ISO psicose inhibits the reaction [Glucose results in increased expression of CCL2 mRNA]; psicose inhibits the reaction [Glucose results in increased expression of CCL2 protein] CTD PMID:17655880 NCBI chr11:82,035,577...82,037,452
Ensembl chr11:82,035,571...82,037,453
JBrowse link
royal jelly term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2 B cell leukemia/lymphoma 2 multiple interactions EXP royal jelly inhibits the reaction [Nicotine results in decreased expression of BCL2 mRNA] CTD PMID:30896085 NCBI chr 1:106,538,176...106,714,290
Ensembl chr 1:106,538,178...106,714,274
JBrowse link
G Casp3 caspase 3 multiple interactions EXP royal jelly inhibits the reaction [Nicotine results in increased expression of CASP3 mRNA] CTD PMID:30896085 NCBI chr 8:46,617,291...46,639,698
Ensembl chr 8:46,617,291...46,639,689
JBrowse link
G Cat catalase multiple interactions ISO
EXP
royal jelly inhibits the reaction [Cisplatin results in decreased activity of CAT protein]
royal jelly inhibits the reaction [Nicotine results in decreased activity of CAT protein]
CTD PMID:20369241 PMID:30896085 NCBI chr 2:103,453,904...103,485,153
Ensembl chr 2:103,453,849...103,485,160
JBrowse link
G Cyp4a14 cytochrome P450, family 4, subfamily a, polypeptide 14 affects expression EXP royal jelly affects the expression of CYP4A14 mRNA CTD PMID:16161764 NCBI chr 4:115,486,200...115,496,158
Ensembl chr 4:115,486,200...115,496,142
JBrowse link
G Esr1 estrogen receptor 1 (alpha) multiple interactions
increases activity
affects binding
ISO Estradiol inhibits the reaction [royal jelly binds to ESR1 protein]; royal jelly binds to and results in increased activity of ESR1 protein; royal jelly inhibits the reaction [Estradiol binds to ESR1 protein]
royal jelly results in increased activity of ESR1 protein
CTD PMID:15946813 PMID:17287592 NCBI chr10:4,611,989...5,005,633
Ensembl chr10:4,611,593...5,005,614
JBrowse link
G Esr2 estrogen receptor 2 (beta) multiple interactions
affects binding
ISO Estradiol inhibits the reaction [royal jelly binds to ESR2 protein]; royal jelly binds to and results in increased activity of ESR2 protein; royal jelly inhibits the reaction [Estradiol binds to ESR2 protein] CTD PMID:15946813 PMID:17287592 NCBI chr12:76,120,419...76,177,259
Ensembl chr12:76,120,419...76,177,259
JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions EXP royal jelly inhibits the reaction [Nicotine results in decreased expression of PCNA protein] CTD PMID:30896085 NCBI chr 2:132,249,286...132,253,180
Ensembl chr 2:132,249,162...132,253,314
JBrowse link
G Tff1 trefoil factor 1 increases expression ISO royal jelly results in increased expression of TFF1 mRNA CTD PMID:15946813 NCBI chr17:31,161,395...31,165,060
Ensembl chr17:31,161,395...31,165,277
JBrowse link
G Trp53 transformation related protein 53 multiple interactions EXP royal jelly inhibits the reaction [Nicotine results in increased expression of TRP53 mRNA] CTD PMID:30896085 NCBI chr11:69,580,348...69,591,873
Ensembl chr11:69,580,359...69,591,873
JBrowse link
G Vegfa vascular endothelial growth factor A increases expression ISO royal jelly results in increased expression of VEGFA mRNA CTD PMID:15946813 PMID:17287592 NCBI chr17:46,016,993...46,032,377
Ensembl chr17:46,016,993...46,032,369
JBrowse link
sedoheptulose 1,7-bisphosphate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Idh2 isocitrate dehydrogenase 2 (NADP+), mitochondrial increases abundance
multiple interactions
EXP IDH2 protein mutant form results in increased abundance of sedoheptulose 1,7-bisphosphate
Triazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of sedoheptulose 1,7-bisphosphate]
CTD PMID:27469509 NCBI chr 7:80,094,845...80,118,608
Ensembl chr 7:80,094,846...80,115,392
JBrowse link
sorbose term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Oat ornithine aminotransferase multiple interactions
decreases activity
ISO Sorbose inhibits the reaction [Cyclic AMP results in increased activity of OAT protein]
Sorbose results in decreased activity of OAT protein
CTD PMID:2827574 NCBI chr 7:132,557,475...132,576,398
Ensembl chr 7:132,557,478...132,576,398
JBrowse link
tagatose term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl2 chemokine (C-C motif) ligand 2 increases secretion ISO tagatose results in increased secretion of CCL2 protein CTD PMID:19158351 NCBI chr11:82,035,577...82,037,452
Ensembl chr11:82,035,571...82,037,453
JBrowse link
topiramate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP-binding cassette, sub-family B (MDR/TAP), member 1A multiple interactions
increases expression
ISO Amino Acids, Peptides, and Proteins inhibits the reaction [topiramate results in increased expression of ABCB1 protein] CTD PMID:18473823 NCBI chr 5:8,567,091...8,748,575
Ensembl chr 5:8,660,077...8,748,575
JBrowse link
G Abcc1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 increases expression ISO topiramate results in increased expression of ABCC1 protein CTD PMID:18473823 NCBI chr16:14,361,453...14,474,878
Ensembl chr16:14,361,558...14,475,737
JBrowse link
G Abcc2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 increases expression ISO topiramate results in increased expression of ABCC2 protein CTD PMID:18473823 NCBI chr19:43,782,308...43,838,332
Ensembl chr19:43,782,192...43,840,740
JBrowse link
G Acadsb acyl-Coenzyme A dehydrogenase, short/branched chain increases expression ISO topiramate results in increased expression of ACADSB mRNA CTD PMID:16979414 NCBI chr 7:131,410,601...131,446,211
Ensembl chr 7:131,410,601...131,448,944
JBrowse link
G Acsl4 acyl-CoA synthetase long-chain family member 4 decreases expression ISO topiramate results in decreased expression of ACSL4 mRNA CTD PMID:16979414 NCBI chr  X:142,317,993...142,390,802
Ensembl chr  X:142,317,993...142,390,535
JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing increases expression
increases secretion
EXP topiramate results in increased expression of ADIPOQ mRNA
topiramate results in increased secretion of ADIPOQ protein
CTD PMID:12927809 NCBI chr16:23,146,536...23,157,968
Ensembl chr16:23,146,536...23,158,028
JBrowse link
G Adra2a adrenergic receptor, alpha 2a increases expression EXP topiramate results in increased expression of ADRA2A mRNA CTD PMID:22489711 NCBI chr19:54,045,259...54,048,982
Ensembl chr19:54,044,151...54,048,982
JBrowse link
G Agxt alanine-glyoxylate aminotransferase increases expression ISO topiramate results in increased expression of AGXT mRNA CTD PMID:16979414 NCBI chr 1:93,135,240...93,145,421
Ensembl chr 1:93,135,240...93,145,421
JBrowse link
G Akt1 thymoma viral proto-oncogene 1 multiple interactions ISO topiramate inhibits the reaction [3-nitropropionic acid results in decreased phosphorylation of AKT1 protein] CTD PMID:29753867 NCBI chr12:112,653,821...112,674,884
Ensembl chr12:112,653,821...112,674,884
JBrowse link
G Ass1 argininosuccinate synthetase 1 decreases expression ISO topiramate results in decreased expression of ASS1 mRNA CTD PMID:16979414 NCBI chr 2:31,470,270...31,520,670
Ensembl chr 2:31,470,207...31,520,672
JBrowse link
G Avpr1a arginine vasopressin receptor 1A decreases expression ISO topiramate results in decreased expression of AVPR1A mRNA CTD PMID:16979414 NCBI chr10:122,448,499...122,453,453
Ensembl chr10:122,448,499...122,453,452
JBrowse link
G Bdnf brain derived neurotrophic factor multiple interactions ISO topiramate inhibits the reaction [3-nitropropionic acid results in decreased expression of BDNF protein] CTD PMID:29753867 NCBI chr 2:109,674,700...109,727,043
Ensembl chr 2:109,674,700...109,727,007
JBrowse link
G Calca calcitonin/calcitonin-related polypeptide, alpha multiple interactions ISO Topiramate inhibits the reaction [Potassium Chloride results in increased secretion of CALCA protein]; Topiramate inhibits the reaction [Protons results in increased secretion of CALCA protein]; Topiramate inhibits the reaction [S-nitro-N-acetylpenicillamine results in increased secretion of CALCA protein] CTD PMID:16942474 NCBI chr 7:114,625,981...114,636,910
Ensembl chr 7:114,631,478...114,636,357
JBrowse link
G Capn6 calpain 6 increases expression ISO topiramate results in increased expression of CAPN6 mRNA CTD PMID:16979414 NCBI chr  X:143,802,236...143,827,412
Ensembl chr  X:143,802,231...143,827,414
JBrowse link
G Car1 carbonic anhydrase 1 multiple interactions ISO topiramate binds to and results in decreased activity of CA1 protein CTD PMID:17826101 NCBI chr 3:14,766,214...14,808,365
Ensembl chr 3:14,766,216...14,808,368
JBrowse link
G Car12 carbonic anhydrase 12 decreases activity ISO topiramate results in decreased activity of CA12 protein CTD PMID:21314129 NCBI chr 9:66,712,296...66,766,845
Ensembl chr 9:66,713,686...66,766,845
JBrowse link
G Car2 carbonic anhydrase 2 multiple interactions
decreases activity
ISO topiramate binds to and results in decreased activity of CA2 protein
topiramate results in decreased activity of CA2 protein
CTD PMID:17826101 PMID:21314129 NCBI chr 3:14,886,269...14,900,770
Ensembl chr 3:14,886,273...14,900,770
JBrowse link
G Car3 carbonic anhydrase 3 multiple interactions ISO topiramate binds to and results in decreased activity of CA3 protein CTD PMID:17826101 NCBI chr 3:14,863,538...14,872,381
Ensembl chr 3:14,863,512...14,872,523
JBrowse link
G Casp3 caspase 3 affects expression
multiple interactions
ISO topiramate affects the expression of CASP3 mRNA; topiramate affects the expression of CASP3 protein
topiramate inhibits the reaction [3-nitropropionic acid results in increased activity of CASP3 protein]
CTD PMID:19148780 PMID:29753867 NCBI chr 8:46,617,291...46,639,698
Ensembl chr 8:46,617,291...46,639,689
JBrowse link
G Cebpa CCAAT/enhancer binding protein (C/EBP), alpha decreases expression ISO topiramate results in decreased expression of CEBPA mRNA CTD PMID:16979414 NCBI chr 7:35,119,293...35,121,928
Ensembl chr 7:35,119,293...35,121,928
JBrowse link
G Chka choline kinase alpha decreases expression ISO topiramate results in decreased expression of CHKA mRNA CTD PMID:16979414 NCBI chr19:3,851,585...3,894,369
Ensembl chr19:3,851,773...3,894,369
JBrowse link
G Chrna7 cholinergic receptor, nicotinic, alpha polypeptide 7 decreases expression ISO topiramate results in decreased expression of CHRNA7 mRNA CTD PMID:16979414 NCBI chr 7:63,098,692...63,212,526
Ensembl chr 7:63,098,692...63,212,569
JBrowse link
G Cited2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 decreases expression ISO topiramate results in decreased expression of CITED2 mRNA CTD PMID:16979414 NCBI chr10:17,723,228...17,725,674
Ensembl chr10:17,723,218...17,725,674
JBrowse link
G Cnr1 cannabinoid receptor 1 (brain) affects expression EXP topiramate affects the expression of CNR1 mRNA CTD PMID:22017514 NCBI chr 4:33,923,171...33,948,831
Ensembl chr 4:33,924,593...33,948,831
JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions ISO topiramate inhibits the reaction [3-nitropropionic acid results in decreased phosphorylation of CREB1 protein] CTD PMID:29753867 NCBI chr 1:64,532,794...64,604,548
Ensembl chr 1:64,532,645...64,604,548
JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 decreases activity ISO topiramate results in decreased activity of CYP17A1 protein CTD PMID:15730543 NCBI chr19:46,667,165...46,673,000
Ensembl chr19:46,667,165...46,673,172
JBrowse link
G Drd2 dopamine receptor D2 increases expression EXP topiramate results in increased expression of DRD2 mRNA CTD PMID:22489711 NCBI chr 9:49,340,360...49,408,177
Ensembl chr 9:49,340,627...49,408,177
JBrowse link
G Dusp1 dual specificity phosphatase 1 increases expression ISO topiramate results in increased expression of DUSP1 mRNA CTD PMID:16979414 NCBI chr17:26,505,591...26,508,472
Ensembl chr17:26,505,590...26,562,128
JBrowse link
G Fabp3 fatty acid binding protein 3, muscle and heart decreases expression ISO topiramate results in decreased expression of FABP3 mRNA CTD PMID:16979414 NCBI chr 4:130,308,738...130,315,463
Ensembl chr 4:130,308,595...130,315,463
JBrowse link
G Gabra1 gamma-aminobutyric acid (GABA) A receptor, subunit alpha 1 multiple interactions ISO topiramate inhibits the reaction [[gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein co-treated with GABRB2 protein co-treated with GABRG2 protein]] which results in increased transport of Chlorides] CTD PMID:11123204 NCBI chr11:42,130,939...42,183,066
Ensembl chr11:42,130,939...42,182,930
JBrowse link
G Gabra2 gamma-aminobutyric acid (GABA) A receptor, subunit alpha 2 multiple interactions ISO topiramate inhibits the reaction [[gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein co-treated with GABRB2 protein co-treated with GABRG2 protein]] which results in increased transport of Chlorides] CTD PMID:11123204 NCBI chr 5:70,958,392...71,095,849
Ensembl chr 5:70,957,597...71,095,849
JBrowse link
G Gabra6 gamma-aminobutyric acid (GABA) A receptor, subunit alpha 6 multiple interactions ISO topiramate promotes the reaction [[gamma-Aminobutyric Acid results in increased activity of [GABRA6 protein co-treated with GABRB2 protein co-treated with GABRG2 protein]] which results in increased transport of Chlorides] CTD PMID:11123204 NCBI chr11:42,306,437...42,321,072
Ensembl chr11:42,306,437...42,321,072
JBrowse link
G Gabrb2 gamma-aminobutyric acid (GABA) A receptor, subunit beta 2 multiple interactions ISO topiramate inhibits the reaction [[gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein co-treated with GABRB2 protein co-treated with GABRG2 protein]] which results in increased transport of Chlorides]; topiramate inhibits the reaction [[gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein co-treated with GABRB2 protein co-treated with GABRG2 protein]] which results in increased transport of Chlorides]; topiramate promotes the reaction [[gamma-Aminobutyric Acid results in increased activity of [GABRA6 protein co-treated with GABRB2 protein co-treated with GABRG2 protein]] which results in increased transport of Chlorides] CTD PMID:11123204 NCBI chr11:42,419,515...42,632,591
Ensembl chr11:42,419,757...42,629,028
JBrowse link
G Gabrg2 gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2 multiple interactions ISO topiramate inhibits the reaction [[gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein co-treated with GABRB2 protein co-treated with GABRG2 protein]] which results in increased transport of Chlorides]; topiramate inhibits the reaction [[gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein co-treated with GABRB2 protein co-treated with GABRG2 protein]] which results in increased transport of Chlorides]; topiramate promotes the reaction [[gamma-Aminobutyric Acid results in increased activity of [GABRA6 protein co-treated with GABRB2 protein co-treated with GABRG2 protein]] which results in increased transport of Chlorides] CTD PMID:11123204 NCBI chr11:41,910,190...42,000,857
Ensembl chr11:41,910,203...42,000,857
JBrowse link
G Glul glutamate-ammonia ligase (glutamine synthetase) decreases activity EXP topiramate results in decreased activity of GLUL protein CTD PMID:10323596 NCBI chr 1:153,899,929...153,909,723
Ensembl chr 1:153,899,944...153,909,723
JBrowse link
G Gnai2 guanine nucleotide binding protein (G protein), alpha inhibiting 2 decreases expression ISO topiramate results in decreased expression of GNAI2 mRNA CTD PMID:16979414 NCBI chr 9:107,614,125...107,635,391
Ensembl chr 9:107,614,125...107,635,367
JBrowse link
G Got2 glutamatic-oxaloacetic transaminase 2, mitochondrial increases expression ISO topiramate results in increased expression of GOT2 mRNA CTD PMID:16979414 NCBI chr 8:95,864,133...95,888,401
Ensembl chr 8:95,864,134...95,888,547
JBrowse link
G Gpam glycerol-3-phosphate acyltransferase, mitochondrial decreases expression ISO topiramate results in decreased expression of GPAM mRNA CTD PMID:16979414 NCBI chr19:55,067,635...55,127,319
Ensembl chr19:55,067,268...55,127,238
JBrowse link
G Gpd2 glycerol phosphate dehydrogenase 2, mitochondrial increases expression ISO topiramate results in increased expression of GPD2 mRNA CTD PMID:16979414 NCBI chr 2:57,237,678...57,370,719
Ensembl chr 2:57,237,635...57,370,719
JBrowse link
G Gria2 glutamate receptor, ionotropic, AMPA2 (alpha 2) multiple interactions ISO topiramate inhibits the reaction [3-nitropropionic acid results in decreased expression of GRIA2 mRNA] CTD PMID:29753867 NCBI chr 3:80,681,450...80,804,227
Ensembl chr 3:80,681,450...80,802,835
JBrowse link
G Grik1 glutamate receptor, ionotropic, kainate 1 affects response to substance ISO GRIK1 gene SNP affects the susceptibility to topiramate CTD PMID:19331489 NCBI chr16:87,895,901...88,290,863
Ensembl chr16:87,895,900...88,290,265
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions ISO topiramate inhibits the reaction [3-nitropropionic acid results in decreased phosphorylation of GSK3B protein] CTD PMID:29753867 NCBI chr16:38,089,001...38,246,084
Ensembl chr16:38,089,001...38,246,084
JBrowse link
G Gtf2a2 general transcription factor II A, 2 increases expression ISO topiramate results in increased expression of GTF2A2 mRNA CTD PMID:16979414 NCBI chr 9:70,012,548...70,022,866
Ensembl chr 9:70,012,550...70,022,866
JBrowse link
G Gyg glycogenin decreases expression ISO topiramate results in decreased expression of GYG1 mRNA CTD PMID:16979414 NCBI chr 3:20,122,083...20,155,117
Ensembl chr 3:20,122,084...20,155,317
JBrowse link
G H2-DMb1 histocompatibility 2, class II, locus Mb1 affects expression ISO Topiramate affects the expression of HLA-DMB mRNA CTD PMID:25811541 NCBI chr17:34,153,191...34,160,229
Ensembl chr17:34,153,072...34,160,230
JBrowse link
G H2-Q1 histocompatibility 2, Q region locus 1 affects expression ISO topiramate affects the expression of HLA-A mRNA CTD PMID:25811541 NCBI chr17:35,320,525...35,328,142
Ensembl chr17:35,320,405...35,325,099
JBrowse link
G Hmgcs1 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 increases expression ISO topiramate results in increased expression of HMGCS1 mRNA CTD PMID:16979414 NCBI chr13:119,690,351...119,708,260
Ensembl chr13:119,690,379...119,708,260
JBrowse link
G Idi1 isopentenyl-diphosphate delta isomerase increases expression ISO topiramate results in increased expression of IDI1 mRNA CTD PMID:16979414 NCBI chr13:8,885,606...8,892,396
Ensembl chr13:8,885,501...8,892,451
JBrowse link
G Ifi30 interferon gamma inducible protein 30 multiple interactions ISO [topiramate co-treated with Trinitrobenzenesulfonic Acid] results in decreased expression of IFI30 mRNA CTD PMID:21849664 NCBI chr 8:70,762,773...70,766,663
Ensembl chr 8:70,762,774...70,766,663
JBrowse link
G Igf1 insulin-like growth factor 1 decreases expression ISO topiramate results in decreased expression of IGF1 mRNA CTD PMID:16979414 NCBI chr10:87,858,265...87,937,047
Ensembl chr10:87,858,265...87,937,042
JBrowse link
G Itpr1 inositol 1,4,5-trisphosphate receptor 1 increases expression ISO topiramate results in increased expression of ITPR1 mRNA CTD PMID:16979414 NCBI chr 6:108,213,083...108,551,116
Ensembl chr 6:108,213,096...108,551,109
JBrowse link
G Kcnh2 potassium voltage-gated channel, subfamily H (eag-related), member 2 decreases activity ISO topiramate results in decreased activity of KCNH2 protein CTD PMID:15716081 NCBI chr 5:24,319,589...24,351,684
Ensembl chr 5:24,319,589...24,351,604
JBrowse link
G Me1 malic enzyme 1, NADP(+)-dependent, cytosolic decreases expression ISO topiramate results in decreased expression of ME1 mRNA CTD PMID:16979414 NCBI chr 9:86,581,363...86,695,914
Ensembl chr 9:86,581,371...86,695,953
JBrowse link
G Mvd mevalonate (diphospho) decarboxylase increases expression ISO topiramate results in increased expression of MVD mRNA CTD PMID:16979414 NCBI chr 8:122,433,596...122,443,422
Ensembl chr 8:122,433,601...122,443,422
JBrowse link
G Nos2 nitric oxide synthase 2, inducible increases expression ISO topiramate results in increased expression of NOS2 protein CTD PMID:14511393 NCBI chr11:78,920,787...78,960,226
Ensembl chr11:78,920,787...78,960,254
JBrowse link
G Npy neuropeptide Y increases expression ISO topiramate results in increased expression of NPY protein CTD PMID:17572454 NCBI chr 6:49,822,710...49,829,507
Ensembl chr 6:49,822,710...49,829,507
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity ISO topiramate results in increased activity of NR1I2 protein CTD PMID:14636322 NCBI chr16:38,248,349...38,294,849
Ensembl chr16:38,248,323...38,294,824
JBrowse link
G Nr2f2 nuclear receptor subfamily 2, group F, member 2 decreases expression ISO topiramate results in decreased expression of NR2F2 mRNA CTD PMID:16979414 NCBI chr 7:70,351,946...70,366,746
Ensembl chr 7:70,351,944...70,366,735
JBrowse link
G Nr4a2 nuclear receptor subfamily 4, group A, member 2 decreases expression ISO topiramate results in decreased expression of NR4A2 mRNA CTD PMID:16979414 NCBI chr 2:57,106,830...57,124,003
Ensembl chr 2:57,106,830...57,124,003
JBrowse link
G Pde4b phosphodiesterase 4B, cAMP specific decreases expression ISO topiramate results in decreased expression of PDE4B mRNA CTD PMID:16979414 NCBI chr 4:102,087,332...102,607,275
Ensembl chr 4:102,087,543...102,607,259
JBrowse link
G Pdk4 pyruvate dehydrogenase kinase, isoenzyme 4 decreases expression ISO topiramate results in decreased expression of PDK4 mRNA CTD PMID:16979414 NCBI chr 6:5,483,351...5,496,278
Ensembl chr 6:5,483,351...5,496,309
JBrowse link
G Pick1 protein interacting with C kinase 1 multiple interactions ISO topiramate inhibits the reaction [3-nitropropionic acid results in increased expression of PICK1 protein] CTD PMID:29753867 NCBI chr15:79,229,140...79,249,466
Ensembl chr15:79,229,173...79,249,484
JBrowse link
G Plcd4 phospholipase C, delta 4 decreases expression ISO topiramate results in decreased expression of PLCD4 mRNA CTD PMID:16979414 NCBI chr 1:74,541,975...74,565,977
Ensembl chr 1:74,542,888...74,567,794
JBrowse link
G Pld1 phospholipase D1 increases expression ISO topiramate results in increased expression of PLD1 mRNA CTD PMID:16979414 NCBI chr 3:27,938,459...28,133,362
Ensembl chr 3:27,938,695...28,133,362
JBrowse link
G Ppp5c protein phosphatase 5, catalytic subunit increases expression ISO topiramate results in increased expression of PPP5C mRNA CTD PMID:16979414 NCBI chr 7:17,004,640...17,027,914
Ensembl chr 7:17,004,640...17,027,924
JBrowse link
G Prkag1 protein kinase, AMP-activated, gamma 1 non-catalytic subunit decreases expression ISO topiramate results in decreased expression of PRKAG1 mRNA CTD PMID:16979414 NCBI chr15:98,812,797...98,831,508
Ensembl chr15:98,812,797...98,831,521
JBrowse link
G Prkar2b protein kinase, cAMP dependent regulatory, type II beta decreases expression ISO topiramate results in decreased expression of PRKAR2B mRNA CTD PMID:16979414 NCBI chr12:31,958,450...32,061,648
Ensembl chr12:31,958,476...32,061,296
JBrowse link
G Scd1 stearoyl-Coenzyme A desaturase 1 decreases expression ISO topiramate results in decreased expression of SCD1 mRNA CTD PMID:16979414 NCBI chr19:44,394,450...44,407,709
Ensembl chr19:44,394,455...44,407,879
JBrowse link
G Slc16a1 solute carrier family 16 (monocarboxylic acid transporters), member 1 increases expression ISO topiramate results in increased expression of SLC16A1 mRNA CTD PMID:16979414 NCBI chr 3:104,638,664...104,658,462
Ensembl chr 3:104,638,668...104,658,462
JBrowse link
G Slc37a4 solute carrier family 37 (glucose-6-phosphate transporter), member 4 decreases expression ISO topiramate results in decreased expression of SLC37A4 mRNA CTD PMID:16979414 NCBI chr 9:44,396,946...44,402,966
Ensembl chr 9:44,396,852...44,402,968
JBrowse link
G Slc47a1 solute carrier family 47, member 1 multiple interactions ISO topiramate affects the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr11:61,343,400...61,378,842
Ensembl chr11:61,343,401...61,378,345
JBrowse link
G Slc6a6 solute carrier family 6 (neurotransmitter transporter, taurine), member 6 decreases expression ISO topiramate results in decreased expression of SLC6A6 mRNA CTD PMID:16979414 NCBI chr 6:91,684,048...91,759,063
Ensembl chr 6:91,684,053...91,759,066
JBrowse link
G Slc7a1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 decreases expression ISO topiramate results in decreased expression of SLC7A1 mRNA CTD PMID:16979414 NCBI chr 5:148,327,410...148,399,904
Ensembl chr 5:148,327,410...148,399,904
JBrowse link
G Sqle squalene epoxidase decreases expression ISO topiramate results in decreased expression of SQLE mRNA CTD PMID:16979414 NCBI chr15:59,315,092...59,331,193
Ensembl chr15:59,315,077...59,331,192
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 increases expression ISO topiramate results in increased expression of SREBF1 mRNA CTD PMID:16979414 NCBI chr11:60,199,084...60,224,186
Ensembl chr11:60,199,089...60,222,581
JBrowse link
G Th tyrosine hydroxylase affects expression
increases expression
EXP topiramate affects the expression of TH mRNA
topiramate results in increased expression of TH mRNA
CTD PMID:22017514 PMID:22489711 NCBI chr 7:142,892,779...142,899,995
Ensembl chr 7:142,892,752...142,931,128
JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 multiple interactions ISO topiramate inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of TRPV1 mRNA] CTD PMID:21849664 NCBI chr11:73,234,149...73,261,322
Ensembl chr11:73,234,292...73,261,242
JBrowse link
G Ucp3 uncoupling protein 3 (mitochondrial, proton carrier) decreases expression ISO topiramate results in decreased expression of UCP3 mRNA CTD PMID:16979414 NCBI chr 7:100,472,991...100,486,432
Ensembl chr 7:100,472,990...100,486,432
JBrowse link
G Ugt2b34 UDP glucuronosyltransferase 2 family, polypeptide B34 affects response to substance ISO UGT2B7 gene SNP affects the susceptibility to Topiramate CTD PMID:18686368 NCBI chr 5:86,889,770...86,906,937
Ensembl chr 5:86,889,767...86,906,937
JBrowse link
xylulose term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dcxr dicarbonyl L-xylulose reductase multiple interactions
increases metabolic processing
ISO [DCXR protein co-treated with NAD] results in increased reduction of Xylulose; [DCXR protein co-treated with NADP] results in increased reduction of Xylulose; [DCXR protein results in increased metabolism of Xylulose] which results in increased chemical synthesis of Xylitol CTD PMID:28595002 NCBI chr11:120,724,546...120,727,284
Ensembl chr11:120,725,399...120,727,281
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 21771
    chemical entity 21769
      atom 21757
        nonmetal atom 21653
          oxygen atom 20814
            oxygen molecular entity 20814
              organooxygen compound 20308
                carbohydrates and carbohydrate derivatives 12916
                  carbohydrate 12916
                    monosaccharide 4345
                      ketose 408
                        ketoheptose + 1
                        ketohexose + 374
                        ketooctose + 0
                        ketopentose + 2
                        ketose derivative + 3
                        ketotetrose + 0
                        ketotriose + 52
Path 2
Term Annotations click to browse term
  CHEBI ontology 21771
    subatomic particle 21757
      composite particle 21757
        hadron 21757
          baryon 21757
            nucleon 21757
              atomic nucleus 21757
                atom 21757
                  main group element atom 21674
                    p-block element atom 21674
                      carbon group element atom 21487
                        carbon atom 21387
                          organic molecular entity 21387
                            heteroorganic entity 21066
                              organochalcogen compound 20378
                                organooxygen compound 20308
                                  carbohydrates and carbohydrate derivatives 12916
                                    carbohydrate 12916
                                      monosaccharide 4345
                                        ketose 408
                                          ketoheptose + 1
                                          ketohexose + 374
                                          ketooctose + 0
                                          ketopentose + 2
                                          ketose derivative + 3
                                          ketotetrose + 0
                                          ketotriose + 52
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