Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:ketose
go back to main search page
Accession:CHEBI:24978 term browser browse the term
Definition:Ketonic parent sugars (polyhydroxy ketones H[CH(OH)]nC(=O)[CH(OH)]mH) and their intramolecular hemiketals.
Synonyms:related_synonym: ketoses
 alt_id: CHEBI:6131


show annotations for term's descendants           Sort by:
 
3-deoxyglucosone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKR1B15 aldo-keto reductase family 1 member B15 multiple interactions ISO [AKR1B8 protein co-treated with NADP] affects the reduction of 3-deoxyglucosone CTD PMID:18845131 NCBI chr 7:134,549,110...134,579,869
Ensembl chr 7:134,549,110...134,579,875
JBrowse link
beta-D-fructofuranose 1,6-bisphosphate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GAPDH glyceraldehyde-3-phosphate dehydrogenase multiple interactions ISO [GAPDH protein co-treated with fructose-1,6-diphosphate co-treated with NAD] results in increased chemical synthesis of sodium arsenite; [GAPDH protein co-treated with fructose-1,6-diphosphate co-treated with NAD] results in increased reduction of sodium arsenate analog; heptelidic acid inhibits the reaction [[GAPDH protein co-treated with fructose-1,6-diphosphate co-treated with NAD] results in increased reduction of sodium arsenate analog] CTD PMID:15788719 NCBI chr12:6,534,517...6,538,371
Ensembl chr12:6,534,512...6,538,374
JBrowse link
G IDH2 isocitrate dehydrogenase (NADP(+)) 2 multiple interactions
increases abundance
ISO Triazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of fructose-1,6-diphosphate] CTD PMID:27469509 NCBI chr15:90,083,045...90,102,468
Ensembl chr15:90,083,045...90,102,477
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions ISO fructose-1,6-diphosphate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein] CTD PMID:22227475 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions ISO fructose-1,6-diphosphate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein] CTD PMID:22227475 NCBI chr16:30,114,105...30,123,309
Ensembl chr16:30,114,105...30,123,506
JBrowse link
G NOS2 nitric oxide synthase 2 multiple interactions
decreases degradation
ISO fructose-1,6-diphosphate inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; fructose-1,6-diphosphate inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]
fructose-1,6-diphosphate results in decreased degradation of NOS2 mRNA
CTD PMID:22227475 NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529
JBrowse link
beta-D-fructofuranose 2,6-bisphosphate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PFKM phosphofructokinase, muscle multiple interactions EXP fructose 2,6-diphosphate inhibits the reaction [resveratrol results in decreased activity of PFKM protein] CTD PMID:23454376 NCBI chr12:48,105,353...48,146,404
Ensembl chr12:48,105,139...48,146,404
JBrowse link
D-fructofuranose 1,6-bisphosphate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GAPDH glyceraldehyde-3-phosphate dehydrogenase multiple interactions ISO [GAPDH protein co-treated with fructose-1,6-diphosphate co-treated with NAD] results in increased chemical synthesis of sodium arsenite; [GAPDH protein co-treated with fructose-1,6-diphosphate co-treated with NAD] results in increased reduction of sodium arsenate analog; heptelidic acid inhibits the reaction [[GAPDH protein co-treated with fructose-1,6-diphosphate co-treated with NAD] results in increased reduction of sodium arsenate analog] CTD PMID:15788719 NCBI chr12:6,534,517...6,538,371
Ensembl chr12:6,534,512...6,538,374
JBrowse link
G IDH2 isocitrate dehydrogenase (NADP(+)) 2 multiple interactions
increases abundance
ISO Triazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of fructose-1,6-diphosphate] CTD PMID:27469509 NCBI chr15:90,083,045...90,102,468
Ensembl chr15:90,083,045...90,102,477
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions ISO fructose-1,6-diphosphate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein] CTD PMID:22227475 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions ISO fructose-1,6-diphosphate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein] CTD PMID:22227475 NCBI chr16:30,114,105...30,123,309
Ensembl chr16:30,114,105...30,123,506
JBrowse link
G NOS2 nitric oxide synthase 2 multiple interactions
decreases degradation
ISO fructose-1,6-diphosphate inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; fructose-1,6-diphosphate inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]
fructose-1,6-diphosphate results in decreased degradation of NOS2 mRNA
CTD PMID:22227475 NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529
JBrowse link
D-xylulose 5-phosphate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TALDO1 transaldolase 1 increases abundance ISO TALDO1 gene mutant form results in increased abundance of xylulose-5-phosphate CTD PMID:19436114 NCBI chr11:747,464...765,012
Ensembl chr11:747,415...765,012
JBrowse link
dihydroxyacetone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATM ATM serine/threonine kinase decreases expression EXP Dihydroxyacetone results in decreased expression of ATM mRNA CTD PMID:32506039 NCBI chr11:108,222,484...108,369,102
Ensembl chr11:108,223,044...108,369,102
JBrowse link
G CASP10 caspase 10 decreases expression EXP Dihydroxyacetone results in decreased expression of CASP10 mRNA CTD PMID:32506039 NCBI chr 2:201,182,885...201,229,406
Ensembl chr 2:201,182,898...201,229,406
JBrowse link
G CASP3 caspase 3 increases cleavage EXP Dihydroxyacetone results in increased cleavage of CASP3 protein CTD PMID:29193605 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,649,509
JBrowse link
G CCL21 C-C motif chemokine ligand 21 decreases expression EXP Dihydroxyacetone results in decreased expression of CCL21 mRNA CTD PMID:32506039 NCBI chr 9:34,709,005...34,710,136
Ensembl chr 9:34,709,005...34,710,136
JBrowse link
G CCL3 C-C motif chemokine ligand 3 decreases expression EXP Dihydroxyacetone results in decreased expression of CCL3 mRNA CTD PMID:32506039 NCBI chr17:36,088,256...36,090,143
Ensembl chr17:36,088,256...36,090,169
JBrowse link
G CCL4 C-C motif chemokine ligand 4 decreases expression EXP Dihydroxyacetone results in decreased expression of CCL4 mRNA CTD PMID:32506039 NCBI chr17:36,103,827...36,105,614
Ensembl chr17:36,103,827...36,105,621
JBrowse link
G CCNC cyclin C increases expression EXP Dihydroxyacetone results in increased expression of CCNC mRNA CTD PMID:32506039 NCBI chr 6:99,542,387...99,568,814
Ensembl chr 6:99,542,387...99,568,825
JBrowse link
G CDKN1A cyclin dependent kinase inhibitor 1A decreases expression EXP Dihydroxyacetone results in decreased expression of CDKN1A mRNA CTD PMID:32506039 NCBI chr 6:36,676,463...36,687,332
Ensembl chr 6:36,676,460...36,687,337
JBrowse link
G CEL carboxyl ester lipase increases expression ISO
EXP
Dihydroxyacetone results in increased expression of CEL protein CTD PMID:32506039 NCBI chr 9:133,061,981...133,071,861
Ensembl chr 9:133,061,981...133,071,861
JBrowse link
G CHEK2 checkpoint kinase 2 decreases expression EXP Dihydroxyacetone results in decreased expression of CHEK2 mRNA CTD PMID:32506039 NCBI chr22:28,687,743...28,741,866
Ensembl chr22:28,687,743...28,742,422
JBrowse link
G CRYAB crystallin alpha B increases expression EXP Dihydroxyacetone results in increased expression of CRYAB mRNA; Dihydroxyacetone results in increased expression of CRYAB protein CTD PMID:32506039 NCBI chr11:111,908,564...111,923,740
Ensembl chr11:111,908,564...111,923,722
JBrowse link
G CSF2 colony stimulating factor 2 increases expression EXP Dihydroxyacetone results in increased expression of CSF2 mRNA CTD PMID:32506039 NCBI chr 5:132,073,789...132,076,170
Ensembl chr 5:132,073,789...132,076,170
JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 decreases expression EXP Dihydroxyacetone results in decreased expression of CYP1A1 mRNA CTD PMID:32506039 NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536
JBrowse link
G CYP2E1 cytochrome P450 family 2 subfamily E member 1 decreases expression EXP Dihydroxyacetone results in decreased expression of CYP2E1 mRNA CTD PMID:32506039 NCBI chr10:133,527,363...133,539,123
Ensembl chr10:133,520,406...133,561,220
JBrowse link
G CYP7A1 cytochrome P450 family 7 subfamily A member 1 decreases expression EXP Dihydroxyacetone results in decreased expression of CYP7A1 mRNA CTD PMID:32506039 NCBI chr 8:58,490,178...58,500,163
Ensembl chr 8:58,490,178...58,500,163
JBrowse link
G DDIT3 DNA damage inducible transcript 3 increases expression EXP Dihydroxyacetone results in increased expression of DDIT3 mRNA CTD PMID:32506039 NCBI chr12:57,516,588...57,520,517
Ensembl chr12:57,516,588...57,521,737
JBrowse link
G DNAJB4 DnaJ heat shock protein family (Hsp40) member B4 increases expression EXP Dihydroxyacetone results in increased expression of DNAJB4 mRNA CTD PMID:32506039 NCBI chr 1:77,979,175...78,017,964
Ensembl chr 1:77,979,175...78,017,964
JBrowse link
G E2F1 E2F transcription factor 1 increases expression EXP Dihydroxyacetone results in increased expression of E2F1 mRNA CTD PMID:32506039 NCBI chr20:33,675,477...33,686,385
Ensembl chr20:33,675,477...33,686,385
JBrowse link
G EGR1 early growth response 1 affects expression EXP Dihydroxyacetone affects the expression of EGR1 mRNA CTD PMID:32506039 NCBI chr 5:138,465,479...138,469,303
Ensembl chr 5:138,465,479...138,469,303
JBrowse link
G EIF2S1 eukaryotic translation initiation factor 2 subunit alpha increases phosphorylation EXP Dihydroxyacetone results in increased phosphorylation of EIF2S1 protein CTD PMID:32506039 NCBI chr14:67,360,328...67,386,516
Ensembl chr14:67,360,328...67,386,516
JBrowse link
G EPHX2 epoxide hydrolase 2 decreases expression EXP Dihydroxyacetone results in decreased expression of EPHX2 mRNA CTD PMID:32506039 NCBI chr 8:27,491,143...27,597,559
Ensembl chr 8:27,490,781...27,545,564
JBrowse link
G ERCC3 ERCC excision repair 3, TFIIH core complex helicase subunit increases expression EXP Dihydroxyacetone results in increased expression of ERCC3 mRNA CTD PMID:32506039 NCBI chr 2:127,257,290...127,294,166
Ensembl chr 2:127,257,290...127,294,166
JBrowse link
G FASLG Fas ligand affects expression EXP Dihydroxyacetone affects the expression of FASLG mRNA CTD PMID:32506039 NCBI chr 1:172,659,103...172,666,876
Ensembl chr 1:172,659,103...172,666,876
JBrowse link
G FMO1 flavin containing dimethylaniline monoxygenase 1 decreases expression EXP Dihydroxyacetone results in decreased expression of FMO1 mRNA CTD PMID:32506039 NCBI chr 1:171,248,473...171,285,978
Ensembl chr 1:171,248,471...171,285,978
JBrowse link
G GDF15 growth differentiation factor 15 decreases expression EXP Dihydroxyacetone results in decreased expression of GDF15 mRNA CTD PMID:32506039 NCBI chr19:18,382,170...18,389,176
Ensembl chr19:18,374,731...18,389,176
JBrowse link
G GLO1 glyoxalase I affects response to substance EXP GLO1 protein affects the susceptibility to Dihydroxyacetone CTD PMID:32506039 NCBI chr 6:38,675,925...38,703,145
Ensembl chr 6:38,675,925...38,703,145
JBrowse link
G H2AX H2A.X variant histone increases expression EXP Dihydroxyacetone results in increased expression of H2AX protein CTD PMID:32506039 NCBI chr11:119,093,874...119,095,465
Ensembl chr11:119,093,854...119,095,467
JBrowse link
G HMOX1 heme oxygenase 1 increases expression EXP
ISO
Dihydroxyacetone results in increased expression of HMOX1 mRNA; Dihydroxyacetone results in increased expression of HMOX1 protein CTD PMID:32506039 NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,214
JBrowse link
G HSPA1A heat shock protein family A (Hsp70) member 1A increases expression EXP Dihydroxyacetone results in increased expression of HSPA1A mRNA CTD PMID:32506039 NCBI chr 6:31,815,543...31,817,942
Ensembl chr 6:31,815,543...31,817,946
JBrowse link
G HSPA2 heat shock protein family A (Hsp70) member 2 increases expression EXP Dihydroxyacetone results in increased expression of HSPA2 mRNA CTD PMID:32506039 NCBI chr14:64,535,905...64,543,237
Ensembl chr14:64,535,905...64,546,173
JBrowse link
G HSPA6 heat shock protein family A (Hsp70) member 6 increases expression EXP Dihydroxyacetone results in increased expression of HSPA6 protein CTD PMID:32506039 NCBI chr 1:161,524,540...161,526,894
Ensembl chr 1:161,524,540...161,526,894
JBrowse link
G HSPB1 heat shock protein family B (small) member 1 increases phosphorylation EXP Dihydroxyacetone results in increased phosphorylation of HSPB1 protein CTD PMID:32506039 NCBI chr 7:76,302,673...76,304,292
Ensembl chr 7:76,302,673...76,304,295
JBrowse link
G HSPD1 heat shock protein family D (Hsp60) member 1 increases expression EXP Dihydroxyacetone results in increased expression of HSPD1 mRNA CTD PMID:32506039 NCBI chr 2:197,486,584...197,500,274
Ensembl chr 2:197,486,584...197,516,737
JBrowse link
G HSPE1 heat shock protein family E (Hsp10) member 1 increases expression EXP Dihydroxyacetone results in increased expression of HSPE1 mRNA CTD PMID:32506039 NCBI chr 2:197,500,379...197,503,449
Ensembl chr 2:197,500,140...197,503,449
JBrowse link
G IL6 interleukin 6 increases expression EXP Dihydroxyacetone results in increased expression of IL6 mRNA CTD PMID:32506039 NCBI chr 7:22,725,889...22,732,002
Ensembl chr 7:22,725,884...22,732,002
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 increases phosphorylation EXP Dihydroxyacetone results in increased phosphorylation of MAPK1 protein CTD PMID:32506039 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 increases phosphorylation EXP Dihydroxyacetone results in increased phosphorylation of MAPK3 protein CTD PMID:32506039 NCBI chr16:30,114,105...30,123,309
Ensembl chr16:30,114,105...30,123,506
JBrowse link
G MMP10 matrix metallopeptidase 10 decreases secretion EXP Dihydroxyacetone results in decreased secretion of MMP10 protein CTD PMID:30959092 NCBI chr11:102,770,502...102,780,628
Ensembl chr11:102,770,502...102,780,628
JBrowse link
G MMP13 matrix metallopeptidase 13 decreases secretion EXP Dihydroxyacetone results in decreased secretion of MMP13 protein CTD PMID:30959092 NCBI chr11:102,942,995...102,955,732
Ensembl chr11:102,942,995...102,955,732
JBrowse link
G MT2A metallothionein 2A decreases expression EXP Dihydroxyacetone results in decreased expression of MT2A mRNA CTD PMID:32506039 NCBI chr16:56,608,584...56,609,497
Ensembl chr16:56,608,584...56,609,497
JBrowse link
G MUC5AC mucin 5AC, oligomeric mucus/gel-forming decreases secretion EXP Dihydroxyacetone results in decreased secretion of MUC5AC protein CTD PMID:30959092 NCBI chr11:1,157,953...1,201,138
Ensembl chr11:1,157,953...1,201,138
JBrowse link
G NFE2L2 nuclear factor, erythroid 2 like 2 increases expression EXP Dihydroxyacetone results in increased expression of NFE2L2 protein CTD PMID:32506039 NCBI chr 2:177,230,303...177,265,131
Ensembl chr 2:177,227,595...177,392,697
JBrowse link
G NFKB1 nuclear factor kappa B subunit 1 decreases expression EXP Dihydroxyacetone results in decreased expression of NFKB1 mRNA CTD PMID:32506039 NCBI chr 4:102,501,266...102,617,302
Ensembl chr 4:102,501,331...102,617,302
JBrowse link
G NOS2 nitric oxide synthase 2 decreases expression EXP Dihydroxyacetone results in decreased expression of NOS2 mRNA CTD PMID:32506039 NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529
JBrowse link
G OAT ornithine aminotransferase multiple interactions ISO Dihydroxyacetone inhibits the reaction [Cyclic AMP results in increased activity of OAT protein] CTD PMID:2827574 NCBI chr10:124,397,303...124,418,923
Ensembl chr10:124,397,303...124,418,976
JBrowse link
G PARP1 poly(ADP-ribose) polymerase 1 increases cleavage EXP Dihydroxyacetone results in increased cleavage of PARP1 protein CTD PMID:29193605 NCBI chr 1:226,360,691...226,408,093
Ensembl chr 1:226,360,210...226,408,154
JBrowse link
G PCNA proliferating cell nuclear antigen increases expression EXP Dihydroxyacetone results in increased expression of PCNA mRNA CTD PMID:32506039 NCBI chr20:5,114,953...5,126,622
Ensembl chr20:5,114,953...5,126,626
JBrowse link
G TNF tumor necrosis factor increases expression EXP Dihydroxyacetone results in increased expression of TNF mRNA CTD PMID:32506039 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
JBrowse link
G TNFRSF1A TNF receptor superfamily member 1A affects expression EXP Dihydroxyacetone affects the expression of TNFRSF1A mRNA CTD PMID:32506039 NCBI chr12:6,328,771...6,342,076
Ensembl chr12:6,328,757...6,342,114
JBrowse link
G TNFSF10 TNF superfamily member 10 decreases expression EXP Dihydroxyacetone results in decreased expression of TNFSF10 mRNA CTD PMID:32506039 NCBI chr 3:172,505,508...172,523,430
Ensembl chr 3:172,505,508...172,523,475
JBrowse link
G UNG uracil DNA glycosylase decreases expression EXP Dihydroxyacetone results in decreased expression of UNG mRNA CTD PMID:32506039 NCBI chr12:109,097,597...109,110,992
Ensembl chr12:109,097,597...109,110,992
JBrowse link
G XRCC2 X-ray repair cross complementing 2 increases expression EXP Dihydroxyacetone results in increased expression of XRCC2 mRNA; Dihydroxyacetone results in increased expression of XRCC2 protein CTD PMID:32506039 NCBI chr 7:152,644,776...152,676,141
Ensembl chr 7:152,644,776...152,676,141
JBrowse link
dihydroxyacetone phosphate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G IDH2 isocitrate dehydrogenase (NADP(+)) 2 increases abundance
multiple interactions
ISO IDH2 protein mutant form results in increased abundance of Dihydroxyacetone Phosphate
Triazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of Dihydroxyacetone Phosphate]
CTD PMID:27469509 NCBI chr15:90,083,045...90,102,468
Ensembl chr15:90,083,045...90,102,477
JBrowse link
G TPI1 triosephosphate isomerase 1 affects metabolic processing ISO TPI1 protein affects the metabolism of Dihydroxyacetone Phosphate CTD PMID:14762718 NCBI chr12:6,866,834...6,870,948
Ensembl chr12:6,867,119...6,870,948
JBrowse link
fructose term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A1BG alpha-1-B glycoprotein multiple interactions ISO [Fructose co-treated with bisphenol A] results in decreased expression of A1BG protein CTD PMID:26930160 NCBI chr19:58,345,183...58,353,492
Ensembl chr19:58,345,178...58,353,492
JBrowse link
G ABCA1 ATP binding cassette subfamily A member 1 multiple interactions
increases expression
ISO Tea inhibits the reaction [Fructose results in increased expression of ABCA1 mRNA] CTD PMID:19193814 NCBI chr 9:104,781,006...104,928,155
Ensembl chr 9:104,781,006...104,928,155
JBrowse link
G ABCC2 ATP binding cassette subfamily C member 2 decreases expression
multiple interactions
ISO Fructose results in decreased expression of ABCC2 mRNA; Fructose results in decreased expression of ABCC2 protein
Ascorbic Acid inhibits the reaction [Fructose results in decreased expression of ABCC2 mRNA]; Ascorbic Acid inhibits the reaction [Fructose results in decreased expression of ABCC2 protein]; geraniol inhibits the reaction [Fructose results in decreased expression of ABCC2 mRNA]; geraniol inhibits the reaction [Fructose results in decreased expression of ABCC2 protein]
CTD PMID:31005848 NCBI chr10:99,782,602...99,853,741
Ensembl chr10:99,782,640...99,852,594
JBrowse link
G ACACA acetyl-CoA carboxylase alpha multiple interactions
decreases phosphorylation
increases expression
ISO
EXP
FGF21 gene mutant form inhibits the reaction [Fructose results in increased expression of ACACA mRNA]; Phenylbutyrates inhibits the reaction [Fructose results in increased expression of ACACA mRNA]; SCD1 gene mutant form inhibits the reaction [Fructose results in increased expression of ACACA mRNA]; Triolein inhibits the reaction [SCD1 gene mutant form inhibits the reaction [Fructose results in increased expression of ACACA mRNA]]; Triolein promotes the reaction [Fructose results in increased expression of ACACA mRNA]
[Fructose co-treated with Palmitic Acid] results in decreased expression of ACACA protein modified form; [Fructose co-treated with Palmitic Acid] results in increased expression of ACACA protein; Fenofibrate inhibits the reaction [[Fructose co-treated with Palmitic Acid] results in decreased expression of ACACA protein modified form]; Fenofibrate inhibits the reaction [[Fructose co-treated with Palmitic Acid] results in increased expression of ACACA protein]
Fructose results in decreased phosphorylation of ACACA protein
[6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in decreased activity of SIRT1 protein] inhibits the reaction [Fructose results in increased expression of ACACA mRNA]; [Niacinamide results in decreased activity of SIRT1 protein] inhibits the reaction [Fructose results in increased expression of ACACA mRNA]; Fructose inhibits the reaction [Streptozocin results in decreased activity of ACACA protein]; Fructose inhibits the reaction [Streptozocin results in decreased expression of ACACA mRNA]; Rotenone inhibits the reaction [Fructose results in increased expression of ACACA mRNA]
CTD PMID:1973097 PMID:15066988 PMID:21212096 PMID:22698815 PMID:28123933 PMID:31672515 PMID:32730863 NCBI chr17:37,084,992...37,406,836
Ensembl chr17:37,084,992...37,406,836
JBrowse link
G ACACB acetyl-CoA carboxylase beta decreases expression
multiple interactions
increases expression
EXP
ISO
Fructose results in decreased expression of ACACB mRNA
FGF21 gene mutant form inhibits the reaction [Fructose results in increased expression of ACACB mRNA]
CTD PMID:18063403 PMID:19053045 PMID:28123933 NCBI chr12:109,112,666...109,268,226
Ensembl chr12:109,116,595...109,268,226
JBrowse link
G ACADL acyl-CoA dehydrogenase long chain multiple interactions ISO [Fructose co-treated with Copper deficiency] results in decreased expression of ACADL mRNA CTD PMID:25813056 NCBI chr 2:210,187,923...210,225,447
Ensembl chr 2:210,187,126...210,225,447
JBrowse link
G ACADM acyl-CoA dehydrogenase medium chain multiple interactions ISO [Fructose co-treated with Copper deficiency] results in decreased expression of ACADM mRNA CTD PMID:25813056 NCBI chr 1:75,724,709...75,763,679
Ensembl chr 1:75,724,431...75,787,575
JBrowse link
G ACADS acyl-CoA dehydrogenase short chain multiple interactions ISO [Fructose co-treated with bisphenol A] results in decreased expression of ACADS protein CTD PMID:26930160 NCBI chr12:120,725,826...120,740,008
Ensembl chr12:120,725,774...120,740,008
JBrowse link
G ACADVL acyl-CoA dehydrogenase very long chain multiple interactions ISO [Fructose co-treated with bisphenol A] results in increased expression of ACADVL protein; [Fructose co-treated with Copper deficiency] results in decreased expression of ACADVL mRNA CTD PMID:25813056 PMID:26930160 NCBI chr17:7,217,125...7,225,266
Ensembl chr17:7,217,125...7,225,266
JBrowse link
G ACE angiotensin I converting enzyme increases expression
multiple interactions
ISO Fructose results in increased expression of ACE mRNA
[bisphenol A co-treated with Fructose] results in increased expression of ACE mRNA; APLN protein modified form inhibits the reaction [Fructose results in increased expression of ACE mRNA]
CTD PMID:17587757 PMID:27622962 PMID:30710622 NCBI chr17:63,477,061...63,498,373
Ensembl chr17:63,477,061...63,498,380
JBrowse link
G ACLY ATP citrate lyase increases expression ISO Fructose results in increased expression of ACLY mRNA CTD PMID:1396700 NCBI chr17:41,866,916...41,930,542
Ensembl chr17:41,866,917...41,930,542
JBrowse link
G ACOX1 acyl-CoA oxidase 1 multiple interactions
decreases expression
ISO Atorvastatin inhibits the reaction [Fructose results in decreased expression of ACOX1 mRNA] CTD PMID:21122807 NCBI chr17:75,941,507...75,979,199
Ensembl chr17:75,941,507...75,979,177
JBrowse link
G ACSF2 acyl-CoA synthetase family member 2 multiple interactions ISO [Fructose co-treated with bisphenol A] results in increased expression of ACSF2 protein CTD PMID:26930160 NCBI chr17:50,426,218...50,474,845
Ensembl chr17:50,426,158...50,474,845
JBrowse link
G ACTA2 actin alpha 2, smooth muscle increases expression
multiple interactions
ISO Fructose results in increased expression of ACTA2 protein
[Streptozocin co-treated with Fructose] results in increased expression of ACTA2 protein; dapagliflozin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of ACTA2 protein]; Genistein inhibits the reaction [Fructose results in increased expression of ACTA2 protein]; Metformin promotes the reaction [dapagliflozin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of ACTA2 protein]]
CTD PMID:21704028 PMID:30551545 NCBI chr10:88,935,074...88,991,397
Ensembl chr10:88,935,074...88,991,339
JBrowse link
G ADA adenosine deaminase increases activity
multiple interactions
ISO Fructose results in increased activity of ADA protein
Glutamine inhibits the reaction [Fructose results in increased activity of ADA protein]
CTD PMID:31233715 NCBI chr20:44,619,522...44,651,699
Ensembl chr20:44,619,522...44,652,233
JBrowse link
G ADGRE1 adhesion G protein-coupled receptor E1 multiple interactions
increases expression
ISO [gadolinium chloride co-treated with Fructose co-treated with Copper deficiency] results in decreased expression of ADGRE1 mRNA
Fructose results in increased expression of ADGRE1 protein
Ethanol promotes the reaction [Fructose results in increased expression of ADGRE1 protein]; Fructose promotes the reaction [Ethanol results in increased expression of ADGRE1 mRNA]; Fructose promotes the reaction [Ethanol results in increased expression of ADGRE1 protein]
CTD PMID:25813056 PMID:26858005 NCBI chr19:6,887,549...6,940,450
Ensembl chr19:6,887,566...6,940,459
JBrowse link
G ADIPOQ adiponectin, C1Q and collagen domain containing multiple interactions
decreases secretion
increases secretion
decreases expression
increases expression
ISO [Particulate Matter co-treated with Ozone] promotes the reaction [Fructose results in decreased expression of ADIPOQ mRNA]; Curcumin inhibits the reaction [Fructose results in decreased expression of ADIPOQ protein]; geraniol inhibits the reaction [Fructose results in decreased secretion of ADIPOQ protein]; Metformin inhibits the reaction [Fructose results in decreased expression of ADIPOQ protein]; Ozone promotes the reaction [Fructose results in decreased expression of ADIPOQ mRNA]; Particulate Matter promotes the reaction [Fructose results in decreased expression of ADIPOQ mRNA]; Pioglitazone inhibits the reaction [Fructose results in decreased secretion of ADIPOQ protein]; Resveratrol inhibits the reaction [Fructose results in decreased expression of ADIPOQ mRNA]; Resveratrol inhibits the reaction [Fructose results in decreased expression of ADIPOQ protein]; sapropterin inhibits the reaction [Fructose results in decreased expression of ADIPOQ mRNA]; sapropterin inhibits the reaction [Fructose results in decreased expression of ADIPOQ protein]
Fructose results in increased secretion of ADIPOQ protein
Fructose results in decreased expression of ADIPOQ mRNA; Fructose results in decreased expression of ADIPOQ protein
Fructose results in increased expression of ADIPOQ mRNA; Fructose results in increased expression of ADIPOQ protein
CTD PMID:17098227 PMID:19165636 PMID:21122807 PMID:23016136 PMID:23968387 PMID:25108154 PMID:25679220 PMID:26713546 PMID:26973390 PMID:28257781 NCBI chr 3:186,842,710...186,858,463
Ensembl chr 3:186,842,704...186,858,463
JBrowse link
G ADIPOR2 adiponectin receptor 2 decreases expression ISO Fructose results in decreased expression of ADIPOR2 protein CTD PMID:28257781 NCBI chr12:1,691,059...1,788,674
Ensembl chr12:1,688,574...1,788,674
JBrowse link
G AGER advanced glycosylation end-product specific receptor increases expression
multiple interactions
ISO Fructose results in increased expression of AGER protein
Genistein inhibits the reaction [Fructose results in increased expression of AGER protein]; geraniol inhibits the reaction [Fructose results in increased expression of AGER protein]; Pioglitazone inhibits the reaction [Fructose results in increased expression of AGER protein]
CTD PMID:21704028 PMID:25679220 NCBI chr 6:32,180,969...32,184,380
Ensembl chr 6:32,180,968...32,184,322
JBrowse link
G AGT angiotensinogen increases expression
multiple interactions
ISO Fructose results in increased expression of AGT mRNA; Fructose results in increased expression of AGT protein; Fructose results in increased expression of AGT protein modified form
APLN protein modified form inhibits the reaction [Fructose results in increased expression of AGT mRNA]; APLN protein modified form inhibits the reaction [Fructose results in increased expression of AGT protein modified form]; APLN protein modified form inhibits the reaction [Fructose results in increased expression of AGT protein]
CTD PMID:11741341 PMID:16843071 PMID:17587757 PMID:18360027 PMID:30710622 NCBI chr 1:230,702,523...230,745,583
Ensembl chr 1:230,690,776...230,745,576
JBrowse link
G AGTR1 angiotensin II receptor type 1 increases expression
multiple interactions
ISO
EXP
Fructose results in increased expression of AGTR1A mRNA
Fructose results in increased expression of AGTR1 mRNA
APLN protein modified form inhibits the reaction [Fructose results in increased expression of AGTR1A mRNA]; INS protein inhibits the reaction [Fructose results in increased expression of AGTR1A mRNA]
CTD PMID:16843071 PMID:17587757 PMID:18360027 PMID:30710622 PMID:31655124 NCBI chr 3:148,697,903...148,743,003
Ensembl chr 3:148,697,784...148,743,008
JBrowse link
G AGTR2 angiotensin II receptor type 2 increases expression
multiple interactions
ISO Fructose results in increased expression of AGTR2 mRNA
APLN protein modified form inhibits the reaction [Fructose results in increased expression of AGTR2 mRNA]
CTD PMID:30710622 NCBI chr  X:116,170,744...116,174,974
Ensembl chr  X:116,170,744...116,174,974
JBrowse link
G AHR aryl hydrocarbon receptor multiple interactions ISO [Dietary Fats co-treated with Fructose] results in increased expression of AHR mRNA; AHR protein results in increased susceptibility to [Dietary Fats co-treated with Fructose]; NR0B2 protein inhibits the reaction [AHR protein results in increased susceptibility to [Dietary Fats co-treated with Fructose]]; PEMT protein promotes the reaction [AHR protein results in increased susceptibility to [Dietary Fats co-treated with Fructose]] CTD PMID:29416063 NCBI chr 7:17,298,652...17,346,147
Ensembl chr 7:16,916,359...17,346,152
JBrowse link
G AKR1B1 aldo-keto reductase family 1 member B multiple interactions ISO [Fructose co-treated with bisphenol A] results in increased expression of AKR1B1 protein CTD PMID:26930160 NCBI chr 7:134,442,350...134,459,239
Ensembl chr 7:134,442,356...134,459,284
JBrowse link
G AKT1 AKT serine/threonine kinase 1 decreases phosphorylation
increases phosphorylation
multiple interactions
ISO Fructose results in decreased phosphorylation of AKT1 protein
Fructose results in increased phosphorylation of AKT1 protein
[dapagliflozin co-treated with Atorvastatin] inhibits the reaction [[Fructose co-treated with Dietary Fats] results in decreased expression of AKT1 protein]; [Fructose co-treated with Dietary Fats] results in decreased expression of and results in decreased phosphorylation of AKT1 protein; [Fructose co-treated with Oleanolic Acid] results in increased expression of AKT1 mRNA; NOS3 protein inhibits the reaction [Fructose results in decreased phosphorylation of AKT1 protein]; Quercetin inhibits the reaction [Fructose results in decreased phosphorylation of AKT1 protein]; Quercetin inhibits the reaction [Fructose results in increased phosphorylation of AKT1 protein]; Rutin inhibits the reaction [Fructose results in decreased phosphorylation of AKT1 protein]
CTD PMID:18497449 PMID:19008412 PMID:22426011 PMID:23533474 PMID:24704288 PMID:32259528 NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,751
JBrowse link
G ALDOB aldolase, fructose-bisphosphate B increases expression
multiple interactions
ISO Fructose results in increased expression of ALDOB mRNA
FGF21 gene mutant form inhibits the reaction [Fructose results in increased expression of ALDOB mRNA]
CTD PMID:15066988 PMID:18346472 PMID:28123933 NCBI chr 9:101,420,560...101,435,774
Ensembl chr 9:101,420,560...101,449,664
JBrowse link
G ALOX5 arachidonate 5-lipoxygenase increases expression EXP Fructose results in increased expression of ALOX5 mRNA CTD PMID:31655124 NCBI chr10:45,374,209...45,446,121
Ensembl chr10:45,374,176...45,446,119
JBrowse link
G APAF1 apoptotic peptidase activating factor 1 multiple interactions ISO [Fructose co-treated with Dietary Fats] results in increased expression of APAF1 mRNA; troxerutin inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of APAF1 mRNA] CTD PMID:28916335 NCBI chr12:98,645,141...98,735,433
Ensembl chr12:98,645,290...98,735,433
JBrowse link
G APLN apelin multiple interactions ISO APLN protein modified form inhibits the reaction [Fructose results in decreased activity of CAT protein]; APLN protein modified form inhibits the reaction [Fructose results in decreased expression of APLNR mRNA]; APLN protein modified form inhibits the reaction [Fructose results in increased expression of ACE mRNA]; APLN protein modified form inhibits the reaction [Fructose results in increased expression of AGT mRNA]; APLN protein modified form inhibits the reaction [Fructose results in increased expression of AGT protein modified form]; APLN protein modified form inhibits the reaction [Fructose results in increased expression of AGT protein]; APLN protein modified form inhibits the reaction [Fructose results in increased expression of AGTR1A mRNA]; APLN protein modified form inhibits the reaction [Fructose results in increased expression of AGTR2 mRNA] CTD PMID:30710622 NCBI chr  X:129,645,259...129,654,956
Ensembl chr  X:129,645,259...129,654,956
JBrowse link
G APLNR apelin receptor decreases expression
multiple interactions
ISO Fructose results in decreased expression of APLNR mRNA
APLN protein modified form inhibits the reaction [Fructose results in decreased expression of APLNR mRNA]
CTD PMID:30710622 NCBI chr11:57,233,591...57,237,250
Ensembl chr11:57,233,577...57,237,235
JBrowse link
G APOA1 apolipoprotein A1 increases expression
multiple interactions
decreases expression
ISO Fructose results in increased expression of APOA1 mRNA; Fructose results in increased expression of APOA1 protein
Plant Preparations inhibits the reaction [Fructose results in decreased expression of APOA1 protein]
[bisphenol A co-treated with Fructose] results in increased expression of APOA1 protein
CTD PMID:9322794 PMID:23142792 PMID:27531227 NCBI chr11:116,835,751...116,837,950
Ensembl chr11:116,835,751...116,837,622
JBrowse link
G APOA4 apolipoprotein A4 increases expression EXP Fructose results in increased expression of APOA4 mRNA CTD PMID:11983814 NCBI chr11:116,820,700...116,823,304
Ensembl chr11:116,820,700...116,823,304
JBrowse link
G APOB apolipoprotein B multiple interactions
increases expression
ISO [Fructose co-treated with Copper deficiency] results in decreased expression of APOB mRNA; Atorvastatin inhibits the reaction [Fructose results in increased expression of APOB protein]; gadolinium chloride promotes the reaction [[Fructose co-treated with Copper deficiency] results in decreased expression of APOB mRNA]
[FGF21 gene mutant form results in increased susceptibility to Fructose] which results in decreased expression of APOB mRNA; Plant Preparations inhibits the reaction [Fructose results in increased expression of APOB protein]
Fructose results in increased expression of APOB mRNA; Fructose results in increased expression of APOB protein
CTD PMID:8415773 PMID:12065722 PMID:25813056 PMID:27531227 PMID:28123933 NCBI chr 2:21,001,429...21,044,073
Ensembl chr 2:21,001,429...21,044,073
JBrowse link
G ATF4 activating transcription factor 4 increases expression ISO Fructose results in increased expression of ATF4 mRNA CTD PMID:15150374 NCBI chr22:39,514,494...39,522,686
Ensembl chr22:39,519,695...39,522,683
JBrowse link
G ATP1B1 ATPase Na+/K+ transporting subunit beta 1 decreases expression ISO Fructose results in decreased expression of ATP1B1 protein CTD PMID:26930160 NCBI chr 1:169,106,690...169,132,719
Ensembl chr 1:169,105,697...169,132,722
JBrowse link
G ATP2A2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 multiple interactions ISO [Fructose co-treated with Dietary Fats] results in decreased expression of ATP2A2 mRNA; troxerutin inhibits the reaction [[Fructose co-treated with Dietary Fats] results in decreased expression of ATP2A2 mRNA] CTD PMID:28916335 NCBI chr12:110,281,247...110,351,093
Ensembl chr12:110,280,756...110,351,093
JBrowse link
G ATP5MF ATP synthase membrane subunit f multiple interactions
increases expression
ISO [Fructose co-treated with bisphenol A] results in decreased expression of ATP5MF protein
Fructose results in increased expression of ATP5MF protein
CTD PMID:26930160 NCBI chr 7:99,458,195...99,466,167
Ensembl chr 7:99,448,475...99,466,186
JBrowse link
G BAX BCL2 associated X, apoptosis regulator increases expression
multiple interactions
ISO Fructose results in increased expression of BAX protein
[Fructose co-treated with Dietary Fats] results in increased expression of BAX mRNA; [Fructose co-treated with Dietary Fats] results in increased expression of BAX protein; Plant Preparations inhibits the reaction [Fructose results in increased expression of BAX protein]; troxerutin inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of BAX mRNA]; troxerutin inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of BAX protein]
CTD PMID:27531227 PMID:28916335 NCBI chr19:48,954,825...48,961,798
Ensembl chr19:48,954,815...48,961,798
JBrowse link
G BCL2 BCL2 apoptosis regulator decreases expression
increases expression
multiple interactions
ISO
EXP
Fructose results in decreased expression of BCL2 protein
Fructose results in increased expression of BCL2 mRNA
Fructose results in increased expression of BCL2 protein
[Atorvastatin co-treated with dapagliflozin] inhibits the reaction [[Fructose co-treated with Dietary Fats] results in decreased expression of BCL2 protein]; [Fructose co-treated with Dietary Fats] results in decreased expression of BCL2 protein; dapagliflozin inhibits the reaction [[Fructose co-treated with Dietary Fats] results in decreased expression of BCL2 protein]; Kangen-karyu inhibits the reaction [Fructose results in increased expression of BCL2 protein]
[Fructose co-treated with Dietary Fats] results in decreased expression of BCL2 mRNA; [Fructose co-treated with Dietary Fats] results in decreased expression of BCL2 protein; troxerutin inhibits the reaction [[Fructose co-treated with Dietary Fats] results in decreased expression of BCL2 mRNA]; troxerutin inhibits the reaction [[Fructose co-treated with Dietary Fats] results in decreased expression of BCL2 protein]
CTD PMID:17883899 PMID:27531227 PMID:28916335 PMID:31655124 PMID:32259528 NCBI chr18:63,123,346...63,320,280
Ensembl chr18:63,123,346...63,320,128
JBrowse link
G CALCA calcitonin related polypeptide alpha increases expression EXP Fructose results in increased expression of CALCA mRNA CTD PMID:31655124 NCBI chr11:14,966,668...14,972,361
Ensembl chr11:14,966,668...14,972,351
JBrowse link
G CASP1 caspase 1 multiple interactions
increases expression
ISO Allopurinol inhibits the reaction [Fructose results in increased expression of CASP1 protein modified form]; Allopurinol inhibits the reaction [Fructose results in increased expression of CASP1 protein]; Quercetin inhibits the reaction [Fructose results in increased expression of CASP1 protein modified form]; Quercetin inhibits the reaction [Fructose results in increased expression of CASP1 protein]; Rutin inhibits the reaction [Fructose results in increased expression of CASP1 protein]
Fructose results in increased expression of CASP1 protein; Fructose results in increased expression of CASP1 protein modified form
CTD PMID:22426011 PMID:24491314 NCBI chr11:105,025,443...105,035,591
Ensembl chr11:105,025,443...105,035,250
JBrowse link
G CASP3 caspase 3 multiple interactions
decreases expression
increases expression
ISO
EXP
[Fructose co-treated with Dietary Fats] results in increased expression of CASP3 mRNA; [Fructose co-treated with Dietary Fats] results in increased expression of CASP3 protein; troxerutin inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of CASP3 mRNA]; troxerutin inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of CASP3 protein]
[Fructose co-treated with Palmitic Acid] results in increased activity of CASP3 protein; Fenofibrate inhibits the reaction [[Fructose co-treated with Palmitic Acid] results in increased activity of CASP3 protein]
Fructose results in decreased expression of CASP3 mRNA
imoxin inhibits the reaction [Fructose results in increased expression of CASP3 protein]
CTD PMID:28916335 PMID:29430716 PMID:31655124 PMID:32730863 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,649,509
JBrowse link
G CASP7 caspase 7 multiple interactions ISO [Streptozocin co-treated with Fructose] results in increased expression of CASP7 protein; dapagliflozin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of CASP7 protein]; dapagliflozin promotes the reaction [Metformin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of CASP7 protein]]; Metformin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of CASP7 protein]; Metformin promotes the reaction [dapagliflozin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of CASP7 protein]] CTD PMID:30551545 NCBI chr10:113,679,194...113,730,909
Ensembl chr10:113,679,162...113,730,907
JBrowse link
G CASP9 caspase 9 multiple interactions ISO [Fructose co-treated with Dietary Fats] results in increased expression of CASP9 mRNA; [Fructose co-treated with Dietary Fats] results in increased expression of CASP9 protein; troxerutin inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of CASP9 mRNA]; troxerutin inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of CASP9 protein] CTD PMID:28916335 NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534
JBrowse link
G CAT catalase decreases expression
multiple interactions
decreases activity
ISO Fructose results in decreased expression of CAT mRNA; Fructose results in decreased expression of CAT protein
[Fructose co-treated with Dietary Fats] results in decreased activity of CAT protein; troxerutin inhibits the reaction [[Fructose co-treated with Dietary Fats] results in decreased activity of CAT protein]
[Hydrochlorothiazide co-treated with Fructose] results in decreased activity of CAT protein; APLN protein modified form inhibits the reaction [Fructose results in decreased activity of CAT protein]
CTD PMID:11817707 PMID:20470786 PMID:23707192 PMID:28916335 PMID:30710622 NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060
JBrowse link
G CAVIN3 caveolae associated protein 3 multiple interactions ISO [Fructose co-treated with bisphenol A] results in increased expression of CAVIN3 protein CTD PMID:26930160 NCBI chr11:6,318,946...6,320,501
Ensembl chr11:6,318,946...6,320,532
JBrowse link
G CCL2 C-C motif chemokine ligand 2 multiple interactions
increases expression
increases secretion
EXP
ISO
[Fructose co-treated with Uric Acid] results in increased secretion of CCL2 protein; acetovanillone inhibits the reaction [Fructose results in increased secretion of CCL2 protein]; Acetylcysteine inhibits the reaction [Fructose results in increased secretion of CCL2 protein]; Allopurinol inhibits the reaction [[Fructose co-treated with Uric Acid] results in increased secretion of CCL2 protein]; Allopurinol inhibits the reaction [Fructose results in increased secretion of CCL2 protein]; Glucose inhibits the reaction [Fructose results in increased secretion of CCL2 protein]; KHK protein promotes the reaction [Fructose results in increased secretion of CCL2 protein]; Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin inhibits the reaction [Fructose results in increased secretion of CCL2 protein]; Superoxides affects the reaction [Fructose results in increased secretion of CCL2 protein]
Fructose results in increased expression of CCL2 protein
Fructose results in increased expression of CCL2 mRNA
[Dietary Fats co-treated with Fructose] results in increased expression of CCL2 protein; [FGF21 gene mutant form results in increased susceptibility to Fructose] which results in increased expression of CCL2 mRNA; [Fructose co-treated with Ethanol] results in increased expression of CCL2 mRNA; sarpogrelate inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of CCL2 protein]
[Copper deficiency co-treated with Fructose] results in increased expression of CCL2 protein; [Fructose co-treated with Copper deficiency] results in increased expression of CCL2 protein; [Lipopolysaccharides co-treated with Fructose co-treated with Copper deficiency] results in increased expression of CCL2 protein; [Particulate Matter co-treated with Ozone] promotes the reaction [Fructose results in increased expression of CCL2 mRNA]; [Streptozocin co-treated with Fructose] results in increased expression of and results in increased secretion of CCL2 protein; Acarbose inhibits the reaction [Fructose results in increased expression of CCL2 mRNA]; Acarbose inhibits the reaction [Fructose results in increased expression of CCL2 protein]; dapagliflozin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of and results in increased secretion of CCL2 protein]; Deferiprone inhibits the reaction [[Lipopolysaccharides co-treated with Fructose co-treated with Copper deficiency] results in increased expression of CCL2 protein]; Deferoxamine inhibits the reaction [[Lipopolysaccharides co-treated with Fructose co-treated with Copper deficiency] results in increased expression of CCL2 protein]; Fish Oils inhibits the reaction [Fructose results in increased expression of CCL2 protein]; gadolinium chloride inhibits the reaction [[Fructose co-treated with Copper deficiency] results in increased expression of CCL2 protein]; Metformin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of and results in increased secretion of CCL2 protein]; Ozone promotes the reaction [Fructose results in increased expression of CCL2 mRNA]; Particulate Matter promotes the reaction [Fructose results in increased expression of CCL2 mRNA]
Fructose results in increased expression of CCL2 mRNA; Fructose results in increased expression of CCL2 protein
CTD PMID:15752949 PMID:17133782 PMID:19158351 PMID:21781943 PMID:23968387 PMID:25813056 PMID:26824242 PMID:26858005 PMID:28123933 PMID:30551545 PMID:31655124 PMID:31672515 NCBI chr17:34,255,285...34,257,203
Ensembl chr17:34,255,218...34,257,203
JBrowse link
G CCL3 C-C motif chemokine ligand 3 multiple interactions ISO [FGF21 gene mutant form results in increased susceptibility to Fructose] which results in increased expression of CCL3 mRNA CTD PMID:28123933 NCBI chr17:36,088,256...36,090,143
Ensembl chr17:36,088,256...36,090,169
JBrowse link
G CCN2 cellular communication network factor 2 multiple interactions
increases expression
ISO betanin inhibits the reaction [Fructose results in increased expression of CCN2 protein] CTD PMID:25559852 NCBI chr 6:131,948,176...131,951,372
Ensembl chr 6:131,948,176...131,951,372
JBrowse link
G CD163 CD163 molecule multiple interactions ISO [gadolinium chloride co-treated with Fructose co-treated with Copper deficiency] results in decreased expression of CD163 mRNA
[Fructose co-treated with Ethanol] results in increased expression of CD163 mRNA
CTD PMID:25813056 PMID:26858005 NCBI chr12:7,470,811...7,503,808
Ensembl chr12:7,470,811...7,503,893
JBrowse link
G CD36 CD36 molecule decreases expression
multiple interactions
ISO Fructose results in decreased expression of CD36 protein
[Atorvastatin co-treated with dapagliflozin] inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of CD36 protein]; [Fructose co-treated with Dietary Fats] results in increased expression of CD36 protein; dapagliflozin inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of CD36 protein]
CTD PMID:28257781 PMID:32259528 NCBI chr 7:80,602,207...80,679,277
Ensembl chr 7:80,369,575...80,679,277
JBrowse link
G CD68 CD68 molecule multiple interactions ISO [Dietary Fats co-treated with Fructose] results in increased expression of CD68 mRNA; [gadolinium chloride co-treated with Fructose co-treated with Copper deficiency] results in decreased expression of CD68 mRNA; [gadolinium chloride co-treated with Fructose co-treated with Copper deficiency] results in decreased expression of CD68 protein
[FGF21 gene mutant form results in increased susceptibility to Fructose] which results in increased expression of CD68 mRNA; [Fructose co-treated with Ethanol] results in increased expression of CD68 mRNA
CTD PMID:19632207 PMID:25813056 PMID:26858005 PMID:28123933 NCBI chr17:7,579,638...7,582,111
Ensembl chr17:7,579,491...7,582,111
JBrowse link
G CHRM2 cholinergic receptor muscarinic 2 increases expression ISO Fructose results in increased expression of CHRM2 mRNA; Fructose results in increased expression of CHRM2 protein CTD PMID:17707055 NCBI chr 7:136,868,652...137,020,213
Ensembl chr 7:136,868,652...137,020,255
JBrowse link
G CHRM3 cholinergic receptor muscarinic 3 increases expression ISO Fructose results in increased expression of CHRM3 mRNA; Fructose results in increased expression of CHRM3 protein CTD PMID:17707055 NCBI chr 1:239,386,565...239,915,450
Ensembl chr 1:239,386,565...239,915,452
JBrowse link
G CHUK component of inhibitor of nuclear factor kappa B kinase complex increases phosphorylation
multiple interactions
ISO Fructose results in increased phosphorylation of CHUK protein
Quercetin inhibits the reaction [Fructose results in increased phosphorylation of CHUK protein]
CTD PMID:24491314 NCBI chr10:100,188,300...100,229,610
Ensembl chr10:100,188,300...100,229,596
JBrowse link
G CIDEA cell death inducing DFFA like effector a decreases expression
multiple interactions
ISO Fructose results in decreased expression of CIDEA mRNA
[Ozone co-treated with Fructose] results in decreased expression of CIDEA mRNA; [Particulate Matter co-treated with Fructose] results in decreased expression of CIDEA mRNA; [Particulate Matter co-treated with Ozone co-treated with Fructose] results in decreased expression of CIDEA mRNA
CTD PMID:23968387 NCBI chr18:12,254,361...12,277,595
Ensembl chr18:12,254,361...12,277,595
JBrowse link
G CNR1 cannabinoid receptor 1 increases expression
multiple interactions
ISO Fructose results in increased expression of CNR1 mRNA
[Fructose co-treated with Streptozocin] results in decreased expression of CNR1 mRNA; Ghrelin inhibits the reaction [[Fructose co-treated with Streptozocin] results in decreased expression of CNR1 mRNA]
CTD PMID:18627777 PMID:31468622 NCBI chr 6:88,139,864...88,167,349
Ensembl chr 6:88,139,864...88,166,347
JBrowse link
G COQ9 coenzyme Q9 multiple interactions ISO [Fructose co-treated with bisphenol A] results in increased expression of COQ9 protein CTD PMID:26930160 NCBI chr16:57,447,479...57,461,270
Ensembl chr16:57,447,425...57,461,270
JBrowse link
G CP ceruloplasmin multiple interactions ISO [Fructose co-treated with Copper deficiency] results in decreased activity of CP protein; Fructose promotes the reaction [Copper deficiency results in decreased expression of CP protein] CTD PMID:21781943 PMID:25813056 NCBI chr 3:149,162,410...149,222,008
Ensembl chr 3:149,162,410...149,221,829
JBrowse link
G CPT1A carnitine palmitoyltransferase 1A multiple interactions ISO [Dietary Fats co-treated with Fructose] results in increased expression of CPT1A mRNA; [Fructose co-treated with Copper deficiency] results in decreased expression of CPT1A mRNA; [Fructose co-treated with Dietary Fats] results in decreased expression of CPT1A protein CTD PMID:19632207 PMID:25813056 PMID:32259528 NCBI chr11:68,754,620...68,844,410
Ensembl chr11:68,754,620...68,844,410
JBrowse link
G CREB1 cAMP responsive element binding protein 1 increases expression
multiple interactions
ISO Fructose results in increased expression of CREB1 mRNA; Fructose results in increased expression of CREB1 protein
rosiglitazone inhibits the reaction [Fructose results in increased expression of CREB1 mRNA]; rosiglitazone inhibits the reaction [Fructose results in increased expression of CREB1 protein]
CTD PMID:19196556 NCBI chr 2:207,529,943...207,605,988
Ensembl chr 2:207,529,737...207,605,988
JBrowse link
G CRP C-reactive protein multiple interactions
increases expression
ISO [Dietary Fats co-treated with Fructose] results in increased expression of CRP mRNA; Curcumin inhibits the reaction [Fructose results in increased expression of CRP protein]; Metformin inhibits the reaction [Fructose results in increased expression of CRP protein]; resveratrol inhibits the reaction [Fructose results in increased expression of CRP protein] CTD PMID:19632207 PMID:25108154 PMID:26713546 PMID:31672515 NCBI chr 1:159,712,289...159,714,589
Ensembl chr 1:159,712,289...159,714,589
JBrowse link
G CST3 cystatin C multiple interactions ISO [Streptozocin co-treated with Fructose] results in increased expression of CST3 protein; Metformin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of CST3 protein] CTD PMID:30551545 NCBI chr20:23,626,706...23,637,955
Ensembl chr20:23,626,706...23,638,473
JBrowse link
G CX3CL1 C-X3-C motif chemokine ligand 1 increases expression EXP Fructose results in increased expression of CX3CL1 mRNA CTD PMID:31655124 NCBI chr16:57,372,490...57,385,044
Ensembl chr16:57,372,477...57,385,044
JBrowse link
G CYBB cytochrome b-245 beta chain multiple interactions ISO [Dietary Fats co-treated with Fructose] results in increased expression of CYBB mRNA CTD PMID:19632207 NCBI chr  X:37,780,059...37,813,461
Ensembl chr  X:37,780,059...37,813,461
JBrowse link
G CYCS cytochrome c, somatic multiple interactions ISO
EXP
[Atorvastatin co-treated with dapagliflozin] inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of CYCS protein]; [Fructose co-treated with Dietary Fats] results in increased expression of CYCS protein
[Fructose co-treated with Palmitic Acid] results in increased expression of CYCS protein; Fenofibrate inhibits the reaction [[Fructose co-treated with Palmitic Acid] results in increased expression of CYCS protein]
CTD PMID:32259528 PMID:32730863 NCBI chr 7:25,118,656...25,125,260
Ensembl chr 7:25,118,656...25,125,260
JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 multiple interactions ISO [Dietary Fats co-treated with Fructose] results in increased expression of CYP1A1 mRNA CTD PMID:26102010 PMID:29416063 NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536
JBrowse link
G CYP1A2 cytochrome P450 family 1 subfamily A member 2 multiple interactions ISO [Dietary Fats co-treated with Fructose] results in increased expression of CYP1A2 mRNA; alpha-Tocopherol inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of CYP1A2 mRNA]; tetrahydrocurcumin inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of CYP1A2 mRNA] CTD PMID:26102010 NCBI chr15:74,748,845...74,756,607
Ensembl chr15:74,748,845...74,756,607
JBrowse link
G CYP1B1 cytochrome P450 family 1 subfamily B member 1 multiple interactions ISO [Dietary Fats co-treated with Fructose] results in increased expression of CYP1B1 mRNA; [Dietary Fats co-treated with Fructose] results in increased expression of CYP1B1 protein; tetrahydrocurcumin inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of CYP1B1 mRNA]; tetrahydrocurcumin inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of CYP1B1 protein] CTD PMID:26102010 NCBI chr 2:38,067,509...38,076,151
Ensembl chr 2:38,066,973...38,109,902
JBrowse link
G CYP2C8 cytochrome P450 family 2 subfamily C member 8 multiple interactions ISO [Dietary Fats co-treated with Fructose] results in increased expression of CYP2C29 mRNA; [Dietary Fats co-treated with Fructose] results in increased expression of CYP2C29 protein; alpha-Tocopherol inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of CYP2C29 protein]; tetrahydrocurcumin inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of CYP2C29 mRNA]; tetrahydrocurcumin inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of CYP2C29 protein] CTD PMID:26102010 NCBI chr10:95,036,772...95,069,497
Ensembl chr10:95,036,772...95,069,497
JBrowse link
G CYP2E1 cytochrome P450 family 2 subfamily E member 1 decreases expression
multiple interactions
increases expression
ISO Fructose results in decreased expression of CYP2E1 protein
Ethanol promotes the reaction [Fructose results in increased expression of CYP2E1 protein]
CTD PMID:26858005 PMID:28257781 NCBI chr10:133,527,363...133,539,123
Ensembl chr10:133,520,406...133,561,220
JBrowse link
G CYP3A5 cytochrome P450 family 3 subfamily A member 5 multiple interactions ISO [Dietary Fats co-treated with Fructose] results in increased expression of CYP3A11 mRNA; alpha-Tocopherol inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of CYP3A11 mRNA]; tetrahydrocurcumin inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of CYP3A11 mRNA] CTD PMID:26102010 NCBI chr 7:99,648,194...99,679,996
Ensembl chr 7:99,648,194...99,679,998
JBrowse link
G CYP4A22 cytochrome P450 family 4 subfamily A member 22 multiple interactions ISO [Fructose co-treated with Copper deficiency] results in decreased expression of CYP4A1 mRNA; gadolinium chloride promotes the reaction [[Fructose co-treated with Copper deficiency] results in decreased expression of CYP4A1 mRNA] CTD PMID:25813056 NCBI chr 1:47,137,441...47,149,738
Ensembl chr 1:47,137,435...47,149,735
JBrowse link
G DDT D-dopachrome tautomerase decreases expression
multiple interactions
ISO Fructose results in decreased expression of DDT protein
[Fructose co-treated with bisphenol A] results in increased expression of DDT protein
CTD PMID:26930160 NCBI chr22:23,971,370...23,979,828
Ensembl chr22:23,971,365...23,979,828
JBrowse link
G DEK DEK proto-oncogene multiple interactions EXP DEK protein results in decreased chemical synthesis of and results in decreased secretion of Fructose CTD PMID:28558019 NCBI chr 6:18,223,860...18,264,541
Ensembl chr 6:18,223,860...18,264,548
JBrowse link
G DGAT1 diacylglycerol O-acyltransferase 1 multiple interactions ISO [FGF21 gene mutant form results in increased susceptibility to Fructose] which results in increased expression of DGAT1 mRNA CTD PMID:28123933 NCBI chr 8:144,314,584...144,326,852
Ensembl chr 8:144,314,584...144,326,910
JBrowse link
G DGAT2 diacylglycerol O-acyltransferase 2 multiple interactions ISO [FGF21 gene mutant form results in increased susceptibility to Fructose] which results in decreased expression of DGAT2 mRNA CTD PMID:28123933 NCBI chr11:75,768,778...75,801,534
Ensembl chr11:75,759,512...75,801,535
JBrowse link
G DLD dihydrolipoamide dehydrogenase multiple interactions ISO [Fructose co-treated with bisphenol A] results in decreased expression of DLD protein CTD PMID:26930160 NCBI chr 7:107,891,107...107,921,198
Ensembl chr 7:107,891,162...107,931,730
JBrowse link
G DNM1L dynamin 1 like multiple interactions EXP [Fructose co-treated with Palmitic Acid] results in increased expression of DNM1L protein; Fenofibrate inhibits the reaction [[Fructose co-treated with Palmitic Acid] results in increased expression of DNM1L protein] CTD PMID:32730863 NCBI chr12:32,679,296...32,745,650
Ensembl chr12:32,679,200...32,745,650
JBrowse link
G DPT dermatopontin multiple interactions
decreases expression
ISO [Ozone co-treated with Fructose] results in decreased expression of DPT mRNA; [Particulate Matter co-treated with Fructose] results in decreased expression of DPT mRNA; Fructose affects the reaction [[Ozone co-treated with Particulate Matter] results in decreased expression of DPT mRNA]
Fructose results in decreased expression of DPT mRNA
CTD PMID:23968387 NCBI chr 1:168,695,468...168,729,206
Ensembl chr 1:168,695,468...168,729,206
JBrowse link
G ECHS1 enoyl-CoA hydratase, short chain 1 multiple interactions ISO [Fructose co-treated with bisphenol A] results in increased expression of ECHS1 protein CTD PMID:26930160 NCBI chr10:133,362,480...133,373,396
Ensembl chr10:133,362,485...133,373,354
JBrowse link
G EDN1 endothelin 1 increases response to substance
increases expression
multiple interactions
ISO Fructose results in increased susceptibility to EDN1 protein
Fructose results in increased expression of EDN1 mRNA; Fructose results in increased expression of EDN1 protein modified form
KLK1 protein inhibits the reaction [Fructose results in increased expression of EDN1 mRNA]; Metformin inhibits the reaction [Fructose results in increased expression of EDN1 protein]; resveratrol inhibits the reaction [Fructose results in increased expression of EDN1 protein]
CTD PMID:9869011 PMID:11172478 PMID:14568997 PMID:25108154 NCBI chr 6:12,256,463...12,297,194
Ensembl chr 6:12,290,361...12,297,194
JBrowse link
G EDNRA endothelin receptor type A multiple interactions
increases expression
ISO
EXP
KLK1 protein inhibits the reaction [Fructose results in increased expression of EDNRA mRNA] CTD PMID:9869011 PMID:14568997 PMID:31655124 NCBI chr 4:147,481,097...147,544,954
Ensembl chr 4:147,480,917...147,544,954
JBrowse link
G EEF1A2 eukaryotic translation elongation factor 1 alpha 2 multiple interactions ISO [Fructose co-treated with bisphenol A] results in decreased expression of EEF1A2 protein CTD PMID:26930160 NCBI chr20:63,488,014...63,499,083
Ensembl chr20:63,488,013...63,499,239
JBrowse link
G EGF epidermal growth factor multiple interactions
increases uptake
ISO wortmannin inhibits the reaction [EGF protein results in increased uptake of Fructose] CTD PMID:15691865 NCBI chr 4:109,912,883...110,013,766
Ensembl chr 4:109,912,883...110,013,766
JBrowse link
G EIF2AK2 eukaryotic translation initiation factor 2 alpha kinase 2 increases expression
multiple interactions
ISO Fructose results in increased expression of EIF2AK2 protein
imoxin inhibits the reaction [Fructose results in increased expression of EIF2AK2 protein]
CTD PMID:29430716 NCBI chr 2:37,099,210...37,157,065
Ensembl chr 2:37,099,210...37,157,522
JBrowse link
G EIF2AK3 eukaryotic translation initiation factor 2 alpha kinase 3 increases phosphorylation
multiple interactions
ISO Fructose results in increased phosphorylation of EIF2AK3 protein
Phenylbutyrates inhibits the reaction [Fructose results in increased phosphorylation of EIF2AK3 protein]
CTD PMID:22698815 NCBI chr 2:88,556,741...88,627,464
Ensembl chr 2:88,556,741...88,691,518
JBrowse link
G EIF2S1 eukaryotic translation initiation factor 2 subunit alpha increases phosphorylation
multiple interactions
ISO Fructose results in increased phosphorylation of EIF2S1 protein
Phenylbutyrates inhibits the reaction [Fructose results in increased phosphorylation of EIF2S1 protein]
CTD PMID:22698815 NCBI chr14:67,360,328...67,386,516
Ensembl chr14:67,360,328...67,386,516
JBrowse link
G ELOVL6 ELOVL fatty acid elongase 6 increases expression ISO Fructose results in increased expression of ELOVL6 mRNA CTD PMID:15066988 NCBI chr 4:110,045,846...110,199,199
Ensembl chr 4:110,045,846...110,199,199
JBrowse link
G ENTPD2 ectonucleoside triphosphate diphosphohydrolase 2 decreases expression ISO Fructose results in decreased expression of ENTPD2 mRNA CTD PMID:15150374 NCBI chr 9:137,048,107...137,054,061
Ensembl chr 9:137,048,107...137,054,061
JBrowse link
G EZR ezrin multiple interactions ISO [Fructose co-treated with bisphenol A] results in increased expression of EZR protein CTD PMID:26930160 NCBI chr 6:158,765,744...158,819,368
Ensembl chr 6:158,765,741...158,819,368
JBrowse link
G F3 coagulation factor III, tissue factor increases expression EXP Fructose results in increased expression of F3 mRNA CTD PMID:31655124 NCBI chr 1:94,529,173...94,541,759
Ensembl chr 1:94,529,173...94,541,759
JBrowse link
G FABP3 fatty acid binding protein 3 multiple interactions ISO [Fructose co-treated with bisphenol A] results in increased expression of FABP3 protein CTD PMID:26930160 NCBI chr 1:31,359,595...31,373,618
Ensembl chr 1:31,365,253...31,376,850
JBrowse link
G FABP4 fatty acid binding protein 4 multiple interactions ISO [Fructose co-treated with bisphenol A] results in increased expression of FABP4 protein CTD PMID:26930160 NCBI chr 8:81,478,419...81,483,233
Ensembl chr 8:81,478,419...81,483,236
JBrowse link
G FAS Fas cell surface death receptor decreases expression EXP Fructose results in decreased expression of FAS mRNA CTD PMID:31655124 NCBI chr10:88,968,429...89,017,059
Ensembl chr10:88,990,531...89,017,059
JBrowse link
G FASLG Fas ligand increases expression EXP Fructose results in increased expression of FASLG mRNA CTD PMID:31655124 NCBI chr 1:172,659,103...172,666,876
Ensembl chr 1:172,659,103...172,666,876
JBrowse link
G FASN fatty acid synthase multiple interactions
increases expression
increases activity
ISO
EXP
[Atorvastatin co-treated with dapagliflozin] inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of FASN protein]; [Copper deficiency co-treated with Fructose] results in increased expression of FASN protein; [Fenofibrate co-treated with Resveratrol] inhibits the reaction [Fructose results in increased expression of FASN mRNA]; [Fructose co-treated with Dietary Fats] results in increased expression of FASN protein; [gadolinium chloride co-treated with Fructose co-treated with Copper deficiency] results in decreased expression of FASN mRNA; Atorvastatin inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of FASN protein]; dapagliflozin inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of FASN protein]; Fenofibrate inhibits the reaction [Fructose results in increased expression of FASN mRNA]; Resveratrol inhibits the reaction [Fructose results in increased expression of FASN mRNA]; Rosiglitazone inhibits the reaction [Fructose results in increased expression of FASN mRNA]; Tea inhibits the reaction [Fructose results in increased expression of FASN mRNA]
[Fructose co-treated with Palmitic Acid] results in increased expression of FASN protein; Fenofibrate inhibits the reaction [[Fructose co-treated with Palmitic Acid] results in increased expression of FASN protein]
FGF21 gene mutant form inhibits the reaction [Fructose results in increased expression of FASN mRNA]; Phenylbutyrates inhibits the reaction [Fructose results in increased expression of FASN mRNA]; Plant Preparations inhibits the reaction [Fructose results in increased expression of FASN protein]; SCD1 gene mutant form inhibits the reaction [Fructose results in increased expression of FASN mRNA]; Triolein inhibits the reaction [SCD1 gene mutant form inhibits the reaction [Fructose results in increased expression of FASN mRNA]]; Triolein promotes the reaction [Fructose results in increased expression of FASN mRNA]
Fructose results in increased expression of FASN mRNA; Fructose results in increased expression of FASN protein
Fructose results in increased activity of FASN protein
CTD PMID:8759368 PMID:9566986 PMID:12065722 PMID:15066988 PMID:18346472 PMID:19053045 PMID:19193814 PMID:19196556 PMID:21781943 PMID:22698815 PMID:25813056 PMID:26973390 PMID:27531227 PMID:28123933 PMID:28257781 PMID:32259528 PMID:32730863 NCBI chr17:82,078,338...82,098,303
Ensembl chr17:82,078,338...82,098,294
JBrowse link
G FBP1 fructose-bisphosphatase 1 increases activity
increases expression
multiple interactions
ISO Fructose results in increased activity of FBP1 protein
Fructose results in increased expression of FBP1 mRNA
Vanadates inhibits the reaction [Fructose results in increased activity of FBP1 protein]
CTD PMID:15150374 PMID:16920846 PMID:18346472 NCBI chr 9:94,603,133...94,640,263
Ensembl chr 9:94,603,133...94,640,249
JBrowse link
G FGF21 fibroblast growth factor 21 increases secretion
increases expression
multiple interactions
increases response to substance
ISO Fructose results in increased secretion of FGF21 protein
Fructose results in increased expression of FGF21 mRNA
[FGF21 gene mutant form results in increased susceptibility to Fructose] which results in decreased abundance of Blood Glucose; [FGF21 gene mutant form results in increased susceptibility to Fructose] which results in decreased expression of APOB mRNA; [FGF21 gene mutant form results in increased susceptibility to Fructose] which results in decreased expression of DGAT2 mRNA; [FGF21 gene mutant form results in increased susceptibility to Fructose] which results in increased expression of CCL2 mRNA; [FGF21 gene mutant form results in increased susceptibility to Fructose] which results in increased expression of CCL3 mRNA; [FGF21 gene mutant form results in increased susceptibility to Fructose] which results in increased expression of CD68 mRNA; [FGF21 gene mutant form results in increased susceptibility to Fructose] which results in increased expression of DGAT1 mRNA; [FGF21 gene mutant form results in increased susceptibility to Fructose] which results in increased expression of MMP2 mRNA; [FGF21 gene mutant form results in increased susceptibility to Fructose] which results in increased expression of TGFB1 mRNA; [FGF21 gene mutant form results in increased susceptibility to Fructose] which results in increased expression of TGFB2 mRNA; FGF21 gene mutant form inhibits the reaction [Fructose results in increased expression of ACACA mRNA]; FGF21 gene mutant form inhibits the reaction [Fructose results in increased expression of ACACB mRNA]; FGF21 gene mutant form inhibits the reaction [Fructose results in increased expression of ALDOB mRNA]; FGF21 gene mutant form inhibits the reaction [Fructose results in increased expression of FASN mRNA]; FGF21 gene mutant form inhibits the reaction [Fructose results in increased expression of KHK mRNA]; FGF21 gene mutant form inhibits the reaction [Fructose results in increased expression of MLXIPL mRNA alternative form]; FGF21 gene mutant form inhibits the reaction [Fructose results in increased expression of MTTP mRNA]; FGF21 gene mutant form inhibits the reaction [Fructose results in increased expression of PKLR mRNA]; FGF21 gene mutant form inhibits the reaction [Fructose results in increased expression of SCD1 mRNA]; FGF21 gene mutant form inhibits the reaction [Fructose results in increased secretion of very low density lipoprotein triglyceride]; MLXIPL gene mutant form inhibits the reaction [Fructose results in increased expression of FGF21 mRNA]; MLXIPL gene mutant form inhibits the reaction [Fructose results in increased secretion of FGF21 protein]
CTD PMID:28123933 NCBI chr19:48,755,524...48,758,330
Ensembl chr19:48,755,524...48,758,333
JBrowse link
G FHL2 four and a half LIM domains 2 multiple interactions ISO [Fructose co-treated with bisphenol A] results in decreased expression of FHL2 protein CTD PMID:26930160 NCBI chr 2:105,357,712...105,438,529
Ensembl chr 2:105,357,712...105,438,513
JBrowse link
G FIS1 fission, mitochondrial 1 multiple interactions EXP [Fructose co-treated with Palmitic Acid] results in increased expression of FIS1 protein; Fenofibrate inhibits the reaction [[Fructose co-treated with Palmitic Acid] results in increased expression of FIS1 protein] CTD PMID:32730863 NCBI chr 7:101,239,472...101,245,081
Ensembl chr 7:101,239,458...101,252,316
JBrowse link
G FOS Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression
ISO Dactinomycin inhibits the reaction [Fructose results in increased expression of FOS mRNA] CTD PMID:11123204 PMID:11557636 NCBI chr14:75,278,828...75,282,230
Ensembl chr14:75,278,826...75,282,230
JBrowse link
G FOXO1 forkhead box O1 multiple interactions
increases expression
ISO Fructose results in increased expression of and affects the localization of FOXO1 protein; Fructose results in increased expression of and results in increased phosphorylation of FOXO1 protein; Quercetin inhibits the reaction [Fructose results in increased expression of and affects the localization of FOXO1 protein]; Quercetin inhibits the reaction [Fructose results in increased expression of and results in increased phosphorylation of FOXO1 protein]; rosiglitazone inhibits the reaction [Fructose results in increased expression of FOXO1 mRNA] CTD PMID:19196556 PMID:23533474 NCBI chr13:40,555,667...40,666,641
Ensembl chr13:40,555,667...40,666,641
JBrowse link
G FTH1 ferritin heavy chain 1 increases expression ISO Fructose results in increased expression of FTH1 protein CTD PMID:26930160 NCBI chr11:61,964,285...61,967,634
Ensembl chr11:61,959,718...61,967,634
JBrowse link
G G6PC1 glucose-6-phosphatase catalytic subunit 1 multiple interactions
increases expression
ISO Rosiglitazone inhibits the reaction [Fructose results in increased expression of G6PC1 mRNA]; Rosiglitazone inhibits the reaction [Fructose results in increased expression of G6PC1 protein]
Fructose results in increased expression of G6PC1 mRNA; Fructose results in increased expression of G6PC1 protein
CTD PMID:14988444 PMID:15150374 PMID:16920846 PMID:18346472 PMID:18556366 PMID:19196556 NCBI chr17:42,900,799...42,914,438
Ensembl chr17:42,900,797...42,914,438
JBrowse link
G G6PD glucose-6-phosphate dehydrogenase increases activity
decreases expression
multiple interactions
ISO Fructose results in increased activity of G6PD protein
Fructose results in decreased expression of G6PD protein
Glutamine inhibits the reaction [Fructose results in decreased expression of G6PD protein]
CTD PMID:18346472 PMID:31233715 NCBI chr  X:154,531,390...154,547,569
Ensembl chr  X:154,531,391...154,547,572
JBrowse link
G GCG glucagon multiple interactions ISO GCG protein affects the reaction [Fructose affects the degradation of PKLR mRNA] CTD PMID:2414297 NCBI chr 2:162,142,882...162,152,247
Ensembl chr 2:162,142,882...162,152,404
JBrowse link
G GCK glucokinase increases activity ISO Fructose results in increased activity of GCK protein CTD PMID:20470786 NCBI chr 7:44,143,213...44,189,439
Ensembl chr 7:44,143,213...44,198,170
JBrowse link
G GCKR glucokinase regulator increases expression ISO Fructose results in increased expression of GCKR mRNA CTD PMID:18346472 NCBI chr 2:27,496,839...27,523,689
Ensembl chr 2:27,496,839...27,523,684
JBrowse link
G GHRL ghrelin and obestatin prepropeptide increases expression ISO Fructose results in increased expression of GHRL protein CTD PMID:18627777 NCBI chr 3:10,285,666...10,292,947
Ensembl chr 3:10,285,666...10,292,947
JBrowse link
G GLP1R glucagon like peptide 1 receptor multiple interactions ISO [Fructose co-treated with Streptozocin] results in decreased expression of GLP1R mRNA; Ghrelin inhibits the reaction [[Fructose co-treated with Streptozocin] results in decreased expression of GLP1R mRNA] CTD PMID:31468622 NCBI chr 6:39,048,781...39,091,303
Ensembl chr 6:39,048,781...39,091,303
JBrowse link
G GLUL glutamate-ammonia ligase decreases expression
multiple interactions
ISO Fructose results in decreased expression of GLUL protein
Allopurinol inhibits the reaction [Fructose results in decreased expression of GLUL protein]; Quercetin inhibits the reaction [Fructose results in decreased expression of GLUL protein]
CTD PMID:24491314 NCBI chr 1:182,378,098...182,391,790
Ensembl chr 1:182,378,098...182,392,206
JBrowse link
G GNAT3 G protein subunit alpha transducin 3 affects response to substance ISO GNAT3 protein affects the susceptibility to Fructose CTD PMID:16740645 NCBI chr 7:80,458,635...80,512,064
Ensembl chr 7:80,458,635...80,512,064
JBrowse link
G GNMT glycine N-methyltransferase multiple interactions ISO [Dietary Fats co-treated with Fructose] results in increased expression of GNMT mRNA CTD PMID:29416063 NCBI chr 6:42,960,754...42,963,880
Ensembl chr 6:42,960,754...42,963,880
JBrowse link
G GPAM glycerol-3-phosphate acyltransferase, mitochondrial multiple interactions
increases expression
ISO [Folic Acid affects the susceptibility to Fructose] which affects the expression of GPAM mRNA; Atorvastatin inhibits the reaction [Fructose results in increased expression of GPAM mRNA] CTD PMID:18346472 PMID:19053045 PMID:31612177 NCBI chr10:112,149,865...112,216,306
Ensembl chr10:112,149,865...112,215,377
JBrowse link
G GPLD1 glycosylphosphatidylinositol specific phospholipase D1 increases expression ISO Fructose results in increased expression of GPLD1 protein CTD PMID:16219662 NCBI chr 6:24,423,969...24,495,232
Ensembl chr 6:24,424,565...24,495,205
JBrowse link
G GPT glutamic--pyruvic transaminase increases activity
multiple interactions
ISO Fructose results in increased activity of GPT protein
[dapagliflozin co-treated with Atorvastatin] inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of GPT protein]; [Fructose co-treated with Dietary Fats] results in increased expression of GPT protein; Atorvastatin inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of GPT protein]; dapagliflozin inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of GPT protein]
[Fructose co-treated with Ethanol] results in increased expression of GPT protein; Plant Preparations inhibits the reaction [Fructose results in increased activity of GPT protein]
CTD PMID:26858005 PMID:27531227 PMID:32259528 NCBI chr 8:144,503,068...144,507,172
Ensembl chr 8:144,502,973...144,507,174
JBrowse link
G GPX1 glutathione peroxidase 1 decreases expression ISO Fructose results in decreased expression of GPX1 mRNA CTD PMID:16815490 PMID:20470786 NCBI chr 3:49,357,176...49,358,353
Ensembl chr 3:49,357,176...49,358,353
JBrowse link
G GPX4 glutathione peroxidase 4 decreases expression ISO Fructose results in decreased expression of GPX4 protein CTD PMID:21781943 NCBI chr19:1,103,994...1,106,779
Ensembl chr19:1,103,926...1,106,791
JBrowse link
G GSR glutathione-disulfide reductase increases activity ISO Fructose results in increased activity of GSR protein CTD PMID:17710547 NCBI chr 8:30,678,066...30,727,846
Ensembl chr 8:30,678,066...30,727,846
JBrowse link
G HAMP hepcidin antimicrobial peptide multiple interactions ISO [Fructose co-treated with Copper deficiency] results in decreased expression of HAMP protein CTD PMID:25813056 NCBI chr19:35,282,528...35,285,143
Ensembl chr19:35,280,716...35,285,143
JBrowse link
G HAVCR1 hepatitis A virus cellular receptor 1 multiple interactions ISO [Streptozocin co-treated with Fructose] results in increased expression of HAVCR1 protein; dapagliflozin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of HAVCR1 protein]; dapagliflozin promotes the reaction [Metformin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of HAVCR1 protein]]; Metformin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of HAVCR1 protein]; Metformin promotes the reaction [dapagliflozin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of HAVCR1 protein]] CTD PMID:30551545 NCBI chr 5:157,028,383...157,069,633
Ensembl chr 5:157,029,413...157,059,119
JBrowse link
G HBB hemoglobin subunit beta multiple interactions ISO Fructose promotes the reaction [Glucose binds to HBB protein]; geraniol inhibits the reaction [Fructose promotes the reaction [Glucose binds to HBB protein]]; Pioglitazone inhibits the reaction [Fructose promotes the reaction [Glucose binds to HBB protein]] CTD PMID:25679220 NCBI chr11:5,225,464...5,227,071
Ensembl chr11:5,225,464...5,229,395
JBrowse link
G HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase multiple interactions
increases expression
ISO [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in decreased activity of SIRT1 protein] inhibits the reaction [Fructose results in increased expression of HMGCR mRNA]; [Niacinamide results in decreased activity of SIRT1 protein] inhibits the reaction [Fructose results in increased expression of HMGCR mRNA]; Rotenone inhibits the reaction [Fructose results in increased expression of HMGCR mRNA]; Tea inhibits the reaction [Fructose results in increased expression of HMGCR mRNA] CTD PMID:19193814 PMID:21212096 NCBI chr 5:75,336,334...75,362,116
Ensembl chr 5:75,336,329...75,364,001
JBrowse link
G HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 multiple interactions ISO [Fructose co-treated with Copper deficiency] results in decreased expression of HMGCS2 mRNA; gadolinium chloride promotes the reaction [[Fructose co-treated with Copper deficiency] results in decreased expression of HMGCS2 mRNA] CTD PMID:25813056 NCBI chr 1:119,747,996...119,768,932
Ensembl chr 1:119,748,002...119,768,905
JBrowse link
G HMOX1 heme oxygenase 1 multiple interactions
increases expression
ISO
EXP
[Atorvastatin co-treated with dapagliflozin] inhibits the reaction [[Fructose co-treated with Dietary Fats] results in decreased expression of HMOX1 protein]; [Curcumin co-treated with Fructose] results in increased expression of HMOX1 protein; [Fructose co-treated with Dietary Fats] results in decreased expression of HMOX1 protein; [Hemin co-treated with Fructose] results in increased expression of HMOX1 protein; Atorvastatin inhibits the reaction [[Fructose co-treated with Dietary Fats] results in decreased expression of HMOX1 protein]; caffeic acid phenethyl ester inhibits the reaction [Fructose results in increased expression of HMOX1 protein]; dapagliflozin inhibits the reaction [[Fructose co-treated with Dietary Fats] results in decreased expression of HMOX1 protein]
Fructose results in increased expression of HMOX1 mRNA
CTD PMID:24508943 PMID:25268984 PMID:28257781 PMID:31655124 PMID:32259528 NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,214
JBrowse link
G HNF4A hepatocyte nuclear factor 4 alpha multiple interactions
decreases expression
EXP
ISO
Cerulenin inhibits the reaction [Fructose results in decreased expression of HNF4A mRNA]
Fructose results in decreased expression of HNF4A mRNA; Fructose results in decreased expression of HNF4A protein
Berberine inhibits the reaction [Fructose results in decreased expression of HNF4A mRNA]; Berberine inhibits the reaction [Fructose results in decreased expression of HNF4A protein]; rosiglitazone inhibits the reaction [Fructose results in decreased expression of HNF4A mRNA]
CTD PMID:17992261 PMID:18563319 PMID:19196556 NCBI chr20:44,355,699...44,434,596
Ensembl chr20:44,355,700...44,434,596
JBrowse link
G HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 multiple interactions
decreases expression
ISO [Fructose co-treated with bisphenol A] results in increased expression of HNRNPA2B1 protein
Fructose results in decreased expression of HNRNPA2B1 protein
CTD PMID:26930160 NCBI chr 7:26,189,920...26,200,775
Ensembl chr 7:26,171,151...26,201,529
JBrowse link
G HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 multiple interactions ISO [Fructose co-treated with bisphenol A] results in increased expression of HNRNPA3 protein CTD PMID:26930160 NCBI chr 2:177,212,694...177,223,959
Ensembl chr 2:177,212,563...177,223,958
JBrowse link
G HNRNPK heterogeneous nuclear ribonucleoprotein K multiple interactions ISO [Fructose co-treated with bisphenol A] results in increased expression of HNRNPK protein CTD PMID:26930160 NCBI chr 9:83,968,083...83,980,630
Ensembl chr 9:83,968,083...83,980,616
JBrowse link
G HOXC9 homeobox C9 decreases expression
multiple interactions
ISO Fructose results in decreased expression of HOXC9 mRNA
[Ozone co-treated with Fructose] results in decreased expression of HOXC9 mRNA; [Particulate Matter co-treated with Ozone co-treated with Fructose] results in decreased expression of HOXC9 mRNA; Fructose affects the reaction [Particulate Matter results in decreased expression of HOXC9 mRNA]
CTD PMID:23968387 NCBI chr12:54,000,161...54,003,337
Ensembl chr12:53,994,895...54,003,337
JBrowse link
G HPRT1 hypoxanthine phosphoribosyltransferase 1 decreases expression EXP Fructose results in decreased expression of HPRT1 mRNA CTD PMID:31655124 NCBI chr  X:134,460,165...134,500,668
Ensembl chr  X:134,460,165...134,520,513
JBrowse link
G HSPA1B heat shock protein family A (Hsp70) member 1B increases expression ISO Fructose results in increased expression of HSPA1B mRNA CTD PMID:15150374 NCBI chr 6:31,827,738...31,830,254
Ensembl chr 6:31,827,738...31,830,254
JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 increases expression
multiple interactions
ISO Fructose results in increased expression of HSPA5 mRNA; Fructose results in increased expression of HSPA5 protein
Phenylbutyrates inhibits the reaction [Fructose results in increased expression of HSPA5 protein]
CTD PMID:22698815 NCBI chr 9:125,234,853...125,241,343
Ensembl chr 9:125,234,853...125,241,382
JBrowse link
G HSPD1 heat shock protein family D (Hsp60) member 1 multiple interactions
increases expression
ISO Amlodipine inhibits the reaction [Fructose results in increased expression of HSPD1 protein]; rosiglitazone inhibits the reaction [Fructose results in increased expression of HSPD1 protein] CTD PMID:18948349 PMID:26930160 NCBI chr 2:197,486,584...197,500,274
Ensembl chr 2:197,486,584...197,516,737
JBrowse link
G HSPE1 heat shock protein family E (Hsp10) member 1 multiple interactions ISO [Fructose co-treated with bisphenol A] results in increased expression of HSPE1 protein CTD PMID:26930160 NCBI chr 2:197,500,379...197,503,449
Ensembl chr 2:197,500,140...197,503,449
JBrowse link
G ICAM1 intercellular adhesion molecule 1 multiple interactions
increases expression
EXP
ISO
2,2'-(hydroxynitrosohydrazono)bis-ethanamine inhibits the reaction [Fructose results in increased expression of ICAM1 protein]; Adenosine Triphosphate inhibits the reaction [Fructose results in increased expression of ICAM1 protein]
Metformin inhibits the reaction [Fructose results in increased expression of ICAM1 protein modified form]; resveratrol inhibits the reaction [Fructose results in increased expression of ICAM1 protein modified form]
Fructose results in increased expression of ICAM1 mRNA; Fructose results in increased expression of ICAM1 protein
CTD PMID:18508964 PMID:25108154 NCBI chr19:10,271,120...10,286,615
Ensembl chr19:10,271,093...10,286,615
JBrowse link
G IDH3B isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit beta decreases expression ISO Fructose results in decreased expression of IDH3B protein CTD PMID:26930160 NCBI chr20:2,658,394...2,664,216
Ensembl chr20:2,658,395...2,664,219
JBrowse link
G IGFBP3 insulin like growth factor binding protein 3 multiple interactions ISO [Fructose co-treated with Ozone co-treated with Particulate Matter] results in decreased expression of IGFBP3 mRNA; [Fructose co-treated with Ozone] results in decreased expression of IGFBP3 mRNA; [Particulate Matter co-treated with Fructose] results in decreased expression of IGFBP3 mRNA; Fructose affects the reaction [Particulate Matter results in decreased expression of IGFBP3 mRNA] CTD PMID:23968387 NCBI chr 7:45,912,245...45,921,272
Ensembl chr 7:45,912,245...45,921,874
JBrowse link
G IKBKB inhibitor of nuclear factor kappa B kinase subunit beta increases phosphorylation
multiple interactions
ISO Fructose results in increased phosphorylation of IKBKB protein
Allopurinol inhibits the reaction [Fructose results in increased phosphorylation of IKBKB protein]; Quercetin inhibits the reaction [Fructose results in increased phosphorylation of IKBKB protein]
CTD PMID:24491314 NCBI chr 8:42,270,727...42,332,460
Ensembl chr 8:42,271,302...42,332,460
JBrowse link
G IL10 interleukin 10 decreases expression
multiple interactions
ISO Fructose results in decreased expression of IL10 mRNA
[Fructose co-treated with Ozone co-treated with Particulate Matter] results in decreased expression of IL10 mRNA; Fructose affects the reaction [Ozone results in decreased expression of IL10 mRNA]; Fructose affects the reaction [Particulate Matter results in decreased expression of IL10 mRNA]
CTD PMID:23968387 NCBI chr 1:206,767,602...206,772,494
Ensembl chr 1:206,767,602...206,774,541
JBrowse link
G IL18 interleukin 18 multiple interactions
increases expression
ISO Allopurinol inhibits the reaction [Fructose results in increased expression of IL18 protein]; Felodipine inhibits the reaction [Fructose results in increased expression of IL18 mRNA]; Felodipine inhibits the reaction [Fructose results in increased expression of IL18 protein]; Quercetin inhibits the reaction [Fructose results in increased expression of IL18 protein]; Rutin inhibits the reaction [Fructose results in increased expression of IL18 protein]
Fructose results in increased expression of IL18 mRNA; Fructose results in increased expression of IL18 protein
CTD PMID:18504504 PMID:22426011 NCBI chr11:112,143,251...112,164,104
Ensembl chr11:112,143,253...112,164,096
JBrowse link
G IL1B interleukin 1 beta increases expression
increases secretion
multiple interactions
ISO Fructose results in increased expression of IL1B protein
Fructose results in increased secretion of IL1B protein
[Fructose co-treated with Ethanol] results in increased expression of IL1B mRNA
[gadolinium chloride co-treated with Fructose co-treated with Copper deficiency] results in decreased expression of IL1B mRNA; Allopurinol inhibits the reaction [Fructose results in increased expression of IL1B protein]; geraniol inhibits the reaction [Fructose results in increased expression of IL1B protein]; geraniol inhibits the reaction [Fructose results in increased secretion of IL1B protein]; Pioglitazone inhibits the reaction [Fructose results in increased secretion of IL1B protein]; PTMA protein inhibits the reaction [Fructose results in increased expression of IL1B protein]; Quercetin inhibits the reaction [Fructose results in increased expression of IL1B protein]; Rutin inhibits the reaction [Fructose results in increased expression of IL1B protein]; tributylhexadecylphosphonium bromide inhibits the reaction [Fructose results in increased expression of IL1B protein]
CTD PMID:15885234 PMID:22426011 PMID:24491314 PMID:25679220 PMID:25813056 PMID:26358169 PMID:26858005 PMID:31005848 NCBI chr 2:112,829,751...112,836,843
Ensembl chr 2:112,829,751...112,836,816
JBrowse link
G IL2 interleukin 2 increases expression ISO Fructose results in increased expression of IL2 protein CTD PMID:15885234 NCBI chr 4:122,451,470...122,456,725
Ensembl chr 4:122,451,470...122,456,725
JBrowse link
G IL6 interleukin 6 multiple interactions
increases expression
ISO [gadolinium chloride co-treated with Fructose co-treated with Copper deficiency] results in decreased expression of IL6 mRNA; Allopurinol inhibits the reaction [Fructose results in increased expression of IL6 protein]; galangin inhibits the reaction [Fructose results in increased expression of IL6 protein]; Genistein inhibits the reaction [Fructose results in increased expression of IL6 protein]; geraniol inhibits the reaction [Fructose results in increased expression of IL6 protein]; Metformin inhibits the reaction [Fructose results in increased expression of IL6 protein]; PTMA protein inhibits the reaction [Fructose results in increased expression of IL6 protein]; Quercetin inhibits the reaction [Fructose results in increased expression of IL6 protein]; Resveratrol inhibits the reaction [Fructose results in increased expression of IL6 protein]; Rutin inhibits the reaction [Fructose results in increased expression of IL6 protein]; tributylhexadecylphosphonium bromide inhibits the reaction [Fructose results in increased expression of IL6 protein] CTD PMID:15885234 PMID:21704028 PMID:21708140 PMID:22426011 PMID:25108154 PMID:25813056 PMID:26358169 PMID:27531227 PMID:31005848 PMID:31672515 NCBI chr 7:22,725,889...22,732,002
Ensembl chr 7:22,725,884...22,732,002
JBrowse link
G INS insulin decreases response to substance
increases secretion
increases expression
multiple interactions
EXP
ISO
Fructose results in decreased susceptibility to INS protein
Fructose results in increased secretion of INS protein
Fructose results in increased expression of INS protein; Fructose results in increased expression of INS2 mRNA
Curcumin inhibits the reaction [Fructose results in increased expression of INS protein]; Hemin inhibits the reaction [Fructose results in increased expression of INS protein]; INS protein inhibits the reaction [Fructose results in increased expression of AGTR1A mRNA]; Quercetin inhibits the reaction [Fructose results in increased expression of INS2 mRNA]
CTD PMID:12010179 PMID:18360027 PMID:23533474 PMID:25268984 PMID:26713546 NCBI chr11:2,159,779...2,161,209
Ensembl chr11:2,159,779...2,161,221
JBrowse link
G INSIG1 insulin induced gene 1 decreases expression
increases expression
multiple interactions
ISO Fructose results in decreased expression of INSIG1 protein
Fructose results in increased expression of INSIG1 mRNA
Phenylbutyrates inhibits the reaction [Fructose results in decreased expression of INSIG1 protein]
CTD PMID:22698815 NCBI chr 7:155,297,878...155,310,235
Ensembl chr 7:155,297,776...155,310,235
JBrowse link
G INSIG2 insulin induced gene 2 increases expression ISO Fructose results in increased expression of INSIG2 mRNA CTD PMID:22698815 NCBI chr 2:118,088,471...118,110,997
Ensembl chr 2:118,088,452...118,110,997
JBrowse link
G INSR insulin receptor decreases expression
multiple interactions
decreases phosphorylation
ISO Fructose results in decreased expression of INSR mRNA; Fructose results in decreased expression of INSR protein
[Fructose co-treated with Oleanolic Acid] results in increased expression of INSR mRNA; [Fructose co-treated with Sodium Chloride, Dietary deficiency] results in decreased expression of INSR mRNA; [Fructose co-treated with Sodium Chloride, Dietary deficiency] results in decreased expression of INSR protein; Allopurinol inhibits the reaction [Fructose results in decreased phosphorylation of INSR protein]; Quercetin inhibits the reaction [Fructose results in decreased phosphorylation of INSR protein]; Rutin inhibits the reaction [Fructose results in decreased phosphorylation of INSR protein]
CTD PMID:14573337 PMID:14633139 PMID:22426011 PMID:24491314 PMID:24704288 NCBI chr19:7,112,257...7,294,414
Ensembl chr19:7,112,255...7,294,414
JBrowse link
G IRF3 interferon regulatory factor 3 multiple interactions ISO [Fructose co-treated with Ethanol] results in increased expression of IRF3 protein; Fructose promotes the reaction [Ethanol results in increased expression of IRF3 mRNA] CTD PMID:26858005 NCBI chr19:49,659,572...49,665,857
Ensembl chr19:49,659,569...49,665,875
JBrowse link
G IRF7 interferon regulatory factor 7 multiple interactions
increases expression
ISO [Fructose co-treated with Ethanol] results in increased expression of IRF7 protein
Fructose results in increased expression of IRF7 protein
CTD PMID:26858005 NCBI chr11:612,555...615,999
Ensembl chr11:612,553...615,983
JBrowse link
G IRS1 insulin receptor substrate 1 decreases expression
increases phosphorylation
decreases phosphorylation
multiple interactions
affects phosphorylation
ISO Fructose results in decreased expression of IRS1 mRNA; Fructose results in decreased expression of IRS1 protein
Fructose results in increased phosphorylation of IRS1 protein
Fructose results in decreased phosphorylation of IRS1 protein
[Fructose co-treated with Oleanolic Acid] results in increased expression of IRS1 mRNA; [Fructose co-treated with Oleanolic Acid] results in increased expression of IRS1 protein; [Fructose co-treated with resveratrol] results in increased expression of IRS1 mRNA; Allopurinol inhibits the reaction [Fructose results in decreased phosphorylation of IRS1 protein]; Curcumin inhibits the reaction [Fructose affects the phosphorylation of IRS1 protein]; NOS3 protein inhibits the reaction [Fructose results in decreased expression of IRS1 protein]; Oleanolic Acid inhibits the reaction [Fructose results in increased phosphorylation of IRS1 protein]; Quercetin inhibits the reaction [Fructose results in decreased phosphorylation of IRS1 protein]; Rutin inhibits the reaction [Fructose results in decreased phosphorylation of IRS1 protein]
CTD PMID:19008412 PMID:19165636 PMID:22426011 PMID:24704288 PMID:26488877 PMID:26713546 PMID:31672515 NCBI chr 2:226,731,312...226,799,820
Ensembl chr 2:226,731,312...226,799,820
JBrowse link
G IRS2 insulin receptor substrate 2 decreases expression
multiple interactions
ISO Fructose results in decreased expression of IRS2 mRNA; Fructose results in decreased expression of IRS2 protein
NOS3 protein inhibits the reaction [Fructose results in decreased expression of IRS2 protein]; resveratrol inhibits the reaction [Fructose results in decreased expression of IRS2 mRNA]
CTD PMID:19008412 PMID:19165636 PMID:26488877 NCBI chr13:109,752,695...109,786,583
Ensembl chr13:109,752,695...109,786,583
JBrowse link
G ITGB1 integrin subunit beta 1 decreases expression EXP Fructose results in decreased expression of ITGB1 mRNA CTD PMID:31655124 NCBI chr10:32,900,318...32,958,230
Ensembl chr10:32,887,273...33,005,792
JBrowse link
G ITIH3 inter-alpha-trypsin inhibitor heavy chain 3 decreases expression ISO Fructose results in decreased expression of ITIH3 protein CTD PMID:26930160 NCBI chr 3:52,794,796...52,808,799
Ensembl chr 3:52,794,768...52,809,009
JBrowse link
G JAK2 Janus kinase 2 decreases phosphorylation
multiple interactions
ISO Fructose results in decreased phosphorylation of JAK2 protein
Quercetin inhibits the reaction [Fructose results in decreased phosphorylation of JAK2 protein]; Rutin inhibits the reaction [Fructose results in decreased phosphorylation of JAK2 protein]
CTD PMID:22426011 NCBI chr 9:4,984,390...5,129,948
Ensembl chr 9:4,984,390...5,129,948
JBrowse link
G JUN Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression
ISO Dactinomycin inhibits the reaction [Fructose results in increased expression of JUN mRNA] CTD PMID:11123204 PMID:11557636 NCBI chr 1:58,780,791...58,784,047
Ensembl chr 1:58,776,845...58,784,048
JBrowse link
G JUP junction plakoglobin multiple interactions ISO [Fructose co-treated with bisphenol A] results in increased expression of JUP protein CTD PMID:26930160 NCBI chr17:41,754,608...41,786,711
Ensembl chr17:41,754,604...41,786,931
JBrowse link
G KDR kinase insert domain receptor multiple interactions ISO [bisphenol A co-treated with Fructose] results in increased expression of KDR mRNA CTD PMID:27622962 NCBI chr 4:55,078,481...55,125,595
Ensembl chr 4:55,078,481...55,125,595
JBrowse link
G KHK ketohexokinase multiple interactions
increases expression
EXP
ISO
KHK protein promotes the reaction [Fructose results in decreased abundance of Adenosine Triphosphate]; KHK protein promotes the reaction [Fructose results in increased abundance of Reactive Oxygen Species]; KHK protein promotes the reaction [Fructose results in increased secretion of CCL2 protein]
Atorvastatin inhibits the reaction [Fructose results in increased expression of KHK protein]
Fructose results in increased expression of KHK mRNA; Fructose results in increased expression of KHK protein
FGF21 gene mutant form inhibits the reaction [Fructose results in increased expression of KHK mRNA]; Fructose results in increased expression of and results in increased activity of KHK protein
CTD PMID:15066988 PMID:18346472 PMID:18395287 PMID:19158351 PMID:21122807 PMID:26858005 PMID:28123933 NCBI chr 2:27,086,760...27,100,762
Ensembl chr 2:27,086,747...27,100,762
JBrowse link
G KLK1 kallikrein 1 multiple interactions ISO KLK1 protein inhibits the reaction [Fructose results in increased expression of AGTR1B mRNA]; KLK1 protein inhibits the reaction [Fructose results in increased expression of EDN1 mRNA]; KLK1 protein inhibits the reaction [Fructose results in increased expression of EDNRA mRNA] CTD PMID:14568997 NCBI chr19:50,819,146...50,823,787
Ensembl chr19:50,819,146...50,823,787
JBrowse link
G KNG1 kininogen 1 decreases expression ISO Fructose results in decreased expression of MAP1 protein CTD PMID:26930160 NCBI chr 3:186,717,359...186,744,410
Ensembl chr 3:186,717,348...186,744,410
JBrowse link
G KRT18 keratin 18 increases expression ISO Fructose increases expression of Krt18 protein in liver and serum RGD PMID:29989845 RGD:26884460 NCBI chr12:52,948,855...52,952,906
Ensembl chr12:52,948,871...52,952,906
JBrowse link
G LCN2 lipocalin 2 multiple interactions ISO [dapagliflozin co-treated with Atorvastatin] inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of LCN2 protein]; [Fructose co-treated with Dietary Fats] results in increased expression of LCN2 protein; [Streptozocin co-treated with Fructose] results in increased expression of LCN2 protein; Atorvastatin inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of LCN2 protein]; dapagliflozin inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of LCN2 protein]; dapagliflozin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of LCN2 protein]; Metformin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of LCN2 protein] CTD PMID:30551545 PMID:32259528 NCBI chr 9:128,149,453...128,153,453
Ensembl chr 9:128,149,071...128,153,453
JBrowse link
G LCT lactase increases expression ISO Fructose results in increased expression of LCT mRNA CTD PMID:11242478 NCBI chr 2:135,787,850...135,837,195
Ensembl chr 2:135,787,850...135,837,184
JBrowse link
G LDHB lactate dehydrogenase B multiple interactions ISO [Fructose co-treated with bisphenol A] results in decreased expression of LDHB protein CTD PMID:26930160 NCBI chr12:21,635,342...21,657,971
Ensembl chr12:21,635,342...21,757,857
JBrowse link
G LEP leptin increases secretion
increases expression
multiple interactions
ISO Fructose results in increased secretion of LEP protein
Fructose results in increased expression of LEP mRNA; Fructose results in increased expression of LEP protein
[Fenofibrate co-treated with Resveratrol] inhibits the reaction [Fructose results in increased expression of LEP mRNA]; [Ozone co-treated with Fructose] results in increased expression of LEP mRNA; [Particulate Matter co-treated with Fructose] results in increased expression of LEP mRNA; [Particulate Matter co-treated with Ozone co-treated with Fructose] results in increased expression of LEP mRNA; Allopurinol inhibits the reaction [Fructose results in increased expression of LEP protein]; Atorvastatin affects the reaction [Fructose results in increased expression of LEP protein]; Fenofibrate inhibits the reaction [Fructose results in increased expression of LEP mRNA]; Quercetin inhibits the reaction [Fructose results in increased expression of LEP protein]; Quercetin inhibits the reaction [Fructose results in increased secretion of LEP protein]; Resveratrol inhibits the reaction [Fructose results in increased expression of LEP mRNA]; Rutin inhibits the reaction [Fructose results in increased expression of LEP protein]
CTD PMID:10780946 PMID:11741341 PMID:18627777 PMID:19165636 PMID:21122807 PMID:22426011 PMID:23016136 PMID:23533474 PMID:23968387 PMID:26973390 NCBI chr 7:128,241,201...128,257,629
Ensembl chr 7:128,241,278...128,257,629
JBrowse link
G LEPR leptin receptor multiple interactions ISO Allopurinol inhibits the reaction [Fructose results in increased expression of and results in increased phosphorylation of LEPR protein]; Fructose results in increased expression of and results in increased phosphorylation of LEPR protein; Quercetin inhibits the reaction [Fructose results in increased expression of and results in increased phosphorylation of LEPR protein]; Rutin inhibits the reaction [Fructose results in increased expression of and results in increased phosphorylation of LEPR protein] CTD PMID:22426011 NCBI chr 1:65,420,652...65,641,559
Ensembl chr 1:65,420,652...65,641,559
JBrowse link
G LGALS9 galectin 9 multiple interactions
decreases expression
ISO Allopurinol inhibits the reaction [Fructose results in decreased expression of LGALS9 mRNA]; Allopurinol inhibits the reaction [Fructose results in decreased expression of LGALS9 protein]; Quercetin inhibits the reaction [Fructose results in decreased expression of LGALS9 mRNA]; Quercetin inhibits the reaction [Fructose results in decreased expression of LGALS9 protein]; Rutin inhibits the reaction [Fructose results in decreased expression of LGALS9 mRNA]; Rutin inhibits the reaction [Fructose results in decreased expression of LGALS9 protein]
Fructose results in decreased expression of LGALS9 mRNA; Fructose results in decreased expression of LGALS9 protein
CTD PMID:19605544 NCBI chr17:27,631,172...27,649,560
Ensembl chr17:27,629,798...27,649,560
JBrowse link
G MAOA monoamine oxidase A multiple interactions ISO [Fructose co-treated with bisphenol A] results in increased expression of MAOA protein CTD PMID:26930160 NCBI chr  X:43,655,006...43,746,817
Ensembl chr  X:43,654,907...43,746,824
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 increases phosphorylation
decreases phosphorylation
multiple interactions
ISO Fructose results in increased phosphorylation of MAPK1 protein
Fructose results in decreased phosphorylation of MAPK1 protein
Curcumin inhibits the reaction [Fructose results in increased phosphorylation of MAPK1 protein]; Quercetin inhibits the reaction [Fructose results in decreased phosphorylation of MAPK1 protein]; Rutin inhibits the reaction [Fructose results in decreased phosphorylation of MAPK1 protein]
CTD PMID:22426011 PMID:26713546 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 increases phosphorylation
decreases phosphorylation
multiple interactions
ISO Fructose results in increased phosphorylation of MAPK3 protein
Fructose results in decreased phosphorylation of MAPK3 protein
Curcumin inhibits the reaction [Fructose results in increased phosphorylation of MAPK3 protein]; Quercetin inhibits the reaction [Fructose results in decreased phosphorylation of MAPK3 protein]; Rutin inhibits the reaction [Fructose results in decreased phosphorylation of MAPK3 protein]
CTD PMID:22426011 PMID:26713546 NCBI chr16:30,114,105...30,123,309
Ensembl chr16:30,114,105...30,123,506
JBrowse link
G MAPK8 mitogen-activated protein kinase 8 increases expression
multiple interactions
ISO Fructose results in increased expression of MAPK8 protein
imoxin inhibits the reaction [Fructose results in increased expression of MAPK8 protein]
CTD PMID:29430716 NCBI chr10:48,306,673...48,439,360
Ensembl chr10:48,306,639...48,439,360
JBrowse link
G MFN2 mitofusin 2 multiple interactions EXP [Fructose co-treated with Palmitic Acid] results in decreased expression of MFN2 protein; Fenofibrate inhibits the reaction [[Fructose co-treated with Palmitic Acid] results in decreased expression of MFN2 protein] CTD PMID:32730863 NCBI chr 1:11,980,215...12,013,508
Ensembl chr 1:11,980,181...12,015,211
JBrowse link
G MIR33A microRNA 33a multiple interactions ISO [Fructose co-treated with Streptozocin] results in increased expression of MIR33A mRNA; Ghrelin inhibits the reaction [[Fructose co-treated with Streptozocin] results in increased expression of MIR33A mRNA] CTD PMID:31468622 NCBI chr22:41,900,944...41,901,012
Ensembl chr22:41,900,944...41,901,012
JBrowse link
G MLX MAX dimerization protein MLX increases expression ISO Fructose results in increased expression of MLX mRNA CTD PMID:18346472 NCBI chr17:42,567,100...42,573,203
Ensembl chr17:42,567,072...42,573,239
JBrowse link
G MLXIPL MLX interacting protein like multiple interactions
decreases expression
increases expression
increases activity
ISO Atorvastatin inhibits the reaction [Fructose affects the localization of and results in increased activity of MLXIPL protein]; Atorvastatin inhibits the reaction [Fructose results in increased expression of MLXIPL protein]; Fructose affects the localization of and results in increased activity of MLXIPL protein; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Atorvastatin inhibits the reaction [Fructose results in increased activity of MLXIPL protein]]
Fructose results in decreased expression of MLXIPL mRNA
Fructose results in increased expression of MLXIPL mRNA alternative form
FGF21 gene mutant form inhibits the reaction [Fructose results in increased expression of MLXIPL mRNA alternative form]; MLXIPL gene mutant form inhibits the reaction [Fructose results in increased expression of FGF21 mRNA]; MLXIPL gene mutant form inhibits the reaction [Fructose results in increased secretion of FGF21 protein]
Fructose results in increased expression of MLXIPL mRNA; Fructose results in increased expression of MLXIPL protein
CTD PMID:18346472 PMID:19053045 PMID:19799862 PMID:21122807 PMID:28123933 NCBI chr 7:73,593,201...73,624,522
Ensembl chr 7:73,593,194...73,624,543
JBrowse link
G MLYCD malonyl-CoA decarboxylase multiple interactions
decreases expression
ISO [Fenofibrate co-treated with resveratrol] inhibits the reaction [Fructose results in decreased expression of MLYCD mRNA]; Fenofibrate inhibits the reaction [Fructose results in decreased expression of MLYCD mRNA]; resveratrol inhibits the reaction [Fructose results in decreased expression of MLYCD mRNA] CTD PMID:26973390 NCBI chr16:83,899,115...83,927,031
Ensembl chr16:83,899,115...83,951,445
JBrowse link
G MMP2 matrix metallopeptidase 2 multiple interactions ISO [FGF21 gene mutant form results in increased susceptibility to Fructose] which results in increased expression of MMP2 mRNA CTD PMID:28123933 NCBI chr16:55,478,830...55,506,691
Ensembl chr16:55,389,700...55,506,691
JBrowse link
G MMP9 matrix metallopeptidase 9 increases expression EXP Fructose results in increased expression of MMP9 mRNA CTD PMID:31655124 NCBI chr20:46,008,908...46,016,561
Ensembl chr20:46,008,908...46,016,561
JBrowse link
G MPST mercaptopyruvate sulfurtransferase multiple interactions ISO [Fructose co-treated with bisphenol A] results in decreased expression of MPST protein CTD PMID:26930160 NCBI chr22:37,019,742...37,029,815
Ensembl chr22:37,019,635...37,029,821
JBrowse link
G MSN moesin multiple interactions ISO [Fructose co-treated with bisphenol A] results in increased expression of MSN protein CTD PMID:26930160 NCBI chr  X:65,588,382...65,741,931
Ensembl chr  X:65,588,377...65,741,931
JBrowse link
G MT-ATP6 mitochondrially encoded ATP synthase membrane subunit 6 increases expression ISO Fructose results in increased expression of ATP6 protein CTD PMID:11934685 NCBI chr MT:8,527...9,207
Ensembl chr MT:8,527...9,207
JBrowse link
G MT-CO2 mitochondrially encoded cytochrome c oxidase II multiple interactions ISO [Fructose co-treated with bisphenol A] results in decreased expression of COX2 protein CTD PMID:26930160 NCBI chr MT:7,586...8,269
Ensembl chr MT:7,586...8,269
JBrowse link
G MT2A metallothionein 2A increases expression
multiple interactions
ISO Fructose results in increased expression of MT2A mRNA
Atorvastatin inhibits the reaction [Fructose results in increased expression of MT2A mRNA]
CTD PMID:21122807 NCBI chr16:56,608,584...56,609,497
Ensembl chr16:56,608,584...56,609,497
JBrowse link
G MTTP microsomal triglyceride transfer protein multiple interactions
increases expression
ISO [Fructose co-treated with Copper deficiency] results in decreased expression of MTTP mRNA
FGF21 gene mutant form inhibits the reaction [Fructose results in increased expression of MTTP mRNA]
CTD PMID:25813056 PMID:28123933 NCBI chr 4:99,564,130...99,623,997
Ensembl chr 4:99,564,081...99,623,997
JBrowse link
G MYC MYC proto-oncogene, bHLH transcription factor decreases expression EXP Fructose results in decreased expression of MYC mRNA CTD PMID:2558650 NCBI chr 8:127,735,434...127,742,951
Ensembl chr 8:127,735,434...127,742,951
JBrowse link
G MYD88 MYD88 innate immune signal transduction adaptor multiple interactions ISO Fructose promotes the reaction [Ethanol results in increased expression of MYD88 mRNA] CTD PMID:26858005 NCBI chr 3:38,138,661...38,143,022
Ensembl chr 3:38,138,478...38,143,022
JBrowse link
G MYH6 myosin heavy chain 6 increases expression
multiple interactions
ISO Fructose results in increased expression of MYH6 mRNA
SIRT1 protein affects the reaction [Fructose results in increased expression of MYH6 mRNA]
CTD PMID:18192211 NCBI chr14:23,381,987...23,408,273
Ensembl chr14:23,381,982...23,408,273
JBrowse link
G MYH9 myosin heavy chain 9 decreases expression
multiple interactions
ISO Fructose results in decreased expression of MYH9 protein
[Fructose co-treated with bisphenol A] results in increased expression of MYH9 protein
CTD PMID:26930160 NCBI chr22:36,281,280...36,387,967
Ensembl chr22:36,281,280...36,387,967
JBrowse link
G NDUFA5 NADH:ubiquinone oxidoreductase subunit A5 multiple interactions ISO [Fructose co-treated with bisphenol A] results in increased expression of NDUFA5 protein CTD PMID:26930160 NCBI chr 7:123,536,997...123,601,651
Ensembl chr 7:123,536,997...123,557,904
JBrowse link
G NDUFA9 NADH:ubiquinone oxidoreductase subunit A9 multiple interactions ISO [Fructose co-treated with bisphenol A] results in decreased expression of NDUFA9 protein CTD PMID:26930160 NCBI chr12:4,649,114...4,694,317
Ensembl chr12:4,649,095...4,694,317
JBrowse link
G NFATC4 nuclear factor of activated T cells 4 increases expression
multiple interactions
ISO Fructose results in increased expression of NFATC4 protein
tributylhexadecylphosphonium bromide inhibits the reaction [Fructose results in increased expression of NFATC4 protein]
CTD PMID:26358169 NCBI chr14:24,366,911...24,379,604
Ensembl chr14:24,365,673...24,379,604
JBrowse link
G NFE2L2 nuclear factor, erythroid 2 like 2 increases expression
multiple interactions
ISO
EXP
Fructose results in increased expression of NFE2L2 protein
[Fructose co-treated with Palmitic Acid] results in decreased expression of NFE2L2 protein; Fenofibrate inhibits the reaction [[Fructose co-treated with Palmitic Acid] results in decreased expression of NFE2L2 protein]
[Atorvastatin co-treated with dapagliflozin] inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of NFE2L2 protein]; [Fructose co-treated with Dietary Fats] results in increased expression of NFE2L2 protein; Atorvastatin inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of NFE2L2 protein]; dapagliflozin inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of NFE2L2 protein]
Fructose promotes the reaction [PPARD gene mutant form results in increased phosphorylation of NFE2L2 protein]; Plant Preparations inhibits the reaction [Fructose results in increased expression of NFE2L2 protein]
CTD PMID:27531227 PMID:29289645 PMID:32259528 PMID:32730863 NCBI chr 2:177,230,303...177,265,131
Ensembl chr 2:177,227,595...177,392,697
JBrowse link
G NFKBIA NFKB inhibitor alpha increases degradation
increases phosphorylation
multiple interactions
ISO Fructose results in increased degradation of NFKBIA protein
Fructose results in increased phosphorylation of NFKBIA protein
Allopurinol inhibits the reaction [Fructose results in increased phosphorylation of NFKBIA protein]; Curcumin inhibits the reaction [Fructose results in increased degradation of NFKBIA protein]; Quercetin inhibits the reaction [Fructose results in increased phosphorylation of NFKBIA protein]
CTD PMID:24491314 PMID:26713546 NCBI chr14:35,401,513...35,404,749
Ensembl chr14:35,401,513...35,404,749
JBrowse link
G NGF nerve growth factor decreases expression ISO Fructose results in decreased expression of NGF mRNA; Fructose results in decreased expression of NGF protein CTD PMID:18585860 NCBI chr 1:115,285,915...115,338,253
Ensembl chr 1:115,285,904...115,338,770
JBrowse link
G NGFR nerve growth factor receptor decreases expression ISO Fructose results in decreased expression of NGFR mRNA CTD PMID:18585860 NCBI chr17:49,495,293...49,515,008
Ensembl chr17:49,495,293...49,515,008
JBrowse link
G NLRP3 NLR family pyrin domain containing 3 increases expression
multiple interactions
ISO Fructose results in increased expression of NLRP3 protein
Allopurinol inhibits the reaction [Fructose results in increased expression of NLRP3 protein]; Quercetin inhibits the reaction [Fructose results in increased expression of NLRP3 protein]; Rutin inhibits the reaction [Fructose results in increased expression of NLRP3 protein]
CTD PMID:22426011 PMID:24491314 NCBI chr 1:247,416,163...247,448,823
Ensembl chr 1:247,416,156...247,449,108
JBrowse link
G NOS2 nitric oxide synthase 2 multiple interactions
increases expression
ISO 2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [caryophyllene inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of NOS2 protein]]; [Dietary Fats co-treated with Fructose] results in increased expression of NOS2 protein; [Fructose results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide; caryophyllene inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of NOS2 protein]; iodopravadoline inhibits the reaction [caryophyllene inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of NOS2 protein]]; Pioglitazone inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of NOS2 protein]; Resveratrol inhibits the reaction [Fructose results in increased expression of NOS2 mRNA]; Resveratrol inhibits the reaction [Fructose results in increased expression of NOS2 protein]
Fructose results in increased expression of NOS2 mRNA; Fructose results in increased expression of NOS2 protein
CTD PMID:10090849 PMID:26488877 PMID:28257781 PMID:30343038 NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529
JBrowse link
G NOS3 nitric oxide synthase 3 multiple interactions
decreases expression
decreases phosphorylation
decreases activity
ISO
EXP
2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [caryophyllene inhibits the reaction [[Dietary Fats co-treated with Fructose] results in decreased expression of NOS3 protein]]; [bisphenol A co-treated with Fructose] results in increased expression of NOS3 mRNA; [Dietary Fats co-treated with Fructose] results in decreased expression of NOS3 protein; [Resveratrol co-treated with Fructose] results in increased expression of NOS3 mRNA; caryophyllene inhibits the reaction [[Dietary Fats co-treated with Fructose] results in decreased expression of NOS3 protein]; Fish Oils inhibits the reaction [Fructose results in decreased expression of NOS3 mRNA]; Fish Oils inhibits the reaction [Fructose results in decreased expression of NOS3 protein]; iodopravadoline inhibits the reaction [caryophyllene inhibits the reaction [[Dietary Fats co-treated with Fructose] results in decreased expression of NOS3 protein]]; Metformin inhibits the reaction [Fructose results in decreased phosphorylation of NOS3 protein]; NOS3 protein inhibits the reaction [Fructose results in decreased expression of IRS1 protein]; NOS3 protein inhibits the reaction [Fructose results in decreased expression of IRS2 protein]; NOS3 protein inhibits the reaction [Fructose results in decreased phosphorylation of AKT1 protein]; Pioglitazone inhibits the reaction [[Dietary Fats co-treated with Fructose] results in decreased expression of NOS3 protein]; Resveratrol inhibits the reaction [Fructose results in decreased expression of NOS3 mRNA]; Resveratrol inhibits the reaction [Fructose results in decreased expression of NOS3 protein]; Resveratrol inhibits the reaction [Fructose results in decreased phosphorylation of NOS3 protein]
Fructose results in decreased expression of NOS3 mRNA; Fructose results in decreased expression of NOS3 protein
Fructose results in decreased activity of NOS3 protein
CTD PMID:10580434 PMID:15752949 PMID:18508964 PMID:19008412 PMID:25108154 PMID:26488877 PMID:27622962 PMID:30343038 NCBI chr 7:150,991,017...151,014,588
Ensembl chr 7:150,991,017...151,014,588
JBrowse link
G NOX4 NADPH oxidase 4 increases expression ISO Fructose results in increased expression of NOX4 mRNA CTD PMID:17587757 NCBI chr11:89,324,353...89,589,557
Ensembl chr11:89,324,353...89,498,187
JBrowse link
G NPHS1 NPHS1 adhesion molecule, nephrin multiple interactions ISO [Streptozocin co-treated with Fructose] results in decreased expression of NPHS1 mRNA; dapagliflozin inhibits the reaction [[Streptozocin co-treated with Fructose] results in decreased expression of NPHS1 mRNA]; Metformin inhibits the reaction [[Streptozocin co-treated with Fructose] results in decreased expression of NPHS1 mRNA] CTD PMID:30551545 NCBI chr19:35,862,915...35,869,287
Ensembl chr19:35,825,964...35,869,287
JBrowse link
G NPY neuropeptide Y decreases expression ISO Fructose results in decreased expression of NPY mRNA CTD PMID:18627777 NCBI chr 7:24,284,190...24,291,862
Ensembl chr 7:24,284,188...24,291,862
JBrowse link
G NR0B2 nuclear receptor subfamily 0 group B member 2 multiple interactions ISO NR0B2 protein inhibits the reaction [AHR protein results in increased susceptibility to [Dietary Fats co-treated with Fructose]]; NR0B2 protein results in decreased susceptibility to [Dietary Fats co-treated with Fructose] CTD PMID:29416063 NCBI chr 1:26,911,489...26,914,110
Ensembl chr 1:26,911,489...26,913,975
JBrowse link
G NR2F1 nuclear receptor subfamily 2 group F member 1 multiple interactions EXP Fructose affects the reaction [NR2F1 protein binds to SHBG promoter] CTD PMID:17992261 NCBI chr 5:93,583,222...93,594,613
Ensembl chr 5:93,583,222...93,594,611
JBrowse link
G OAT ornithine aminotransferase multiple interactions ISO Fructose inhibits the reaction [Cyclic AMP results in increased activity of OAT protein]; Fructose inhibits the reaction [Cyclic AMP results in increased expression of OAT mRNA] CTD PMID:2827574 NCBI chr10:124,397,303...124,418,923
Ensembl chr10:124,397,303...124,418,976
JBrowse link
G OGA O-GlcNAcase multiple interactions ISO [Streptozocin co-treated with Fructose] results in increased expression of and results in increased secretion of OGA protein; dapagliflozin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of and results in increased secretion of OGA protein]; Metformin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of and results in increased secretion of OGA protein] CTD PMID:30551545 NCBI chr10:101,784,445...101,818,709
Ensembl chr10:101,784,443...101,818,465
JBrowse link
G OPA1 OPA1 mitochondrial dynamin like GTPase multiple interactions EXP [Fructose co-treated with Palmitic Acid] results in decreased expression of OPA1 protein; Fenofibrate inhibits the reaction [[Fructose co-treated with Palmitic Acid] results in decreased expression of OPA1 protein] CTD PMID:32730863 NCBI chr 3:193,593,149...193,697,811
Ensembl chr 3:193,593,144...193,697,811
JBrowse link
G PAIP2 poly(A) binding protein interacting protein 2 multiple interactions EXP Fructose promotes the reaction [PAIP2 protein binds to SLC2A5 3' UTR] CTD PMID:12820898 NCBI chr 5:139,341,850...139,369,717
Ensembl chr 5:139,341,587...139,369,720
JBrowse link
G PARP1 poly(ADP-ribose) polymerase 1 increases expression ISO Fructose results in increased expression of PARP1 protein CTD PMID:28257781 NCBI chr 1:226,360,691...226,408,093
Ensembl chr 1:226,360,210...226,408,154
JBrowse link
G PCK1 phosphoenolpyruvate carboxykinase 1 multiple interactions
increases expression
increases activity
ISO rosiglitazone inhibits the reaction [Fructose results in increased expression of PCK1 mRNA]; rosiglitazone inhibits the reaction [Fructose results in increased expression of PCK1 protein]
Fructose results in increased expression of PCK1 mRNA; Fructose results in increased expression of PCK1 protein
Fructose results in increased activity of PCK1 protein
CTD PMID:19196556 PMID:21212096 NCBI chr20:57,561,110...57,568,121
Ensembl chr20:57,561,080...57,568,121
JBrowse link
G PCMT1 protein-L-isoaspartate (D-aspartate) O-methyltransferase multiple interactions ISO [Fructose co-treated with bisphenol A] results in increased expression of PCMT1 protein CTD PMID:26930160 NCBI chr 6:149,749,695...149,811,421
Ensembl chr 6:149,749,443...149,811,420
JBrowse link
G PDK1 pyruvate dehydrogenase kinase 1 multiple interactions ISO [Fructose co-treated with bisphenol A] results in increased expression of PDK1 protein CTD PMID:26930160 NCBI chr 2:172,555,373...172,672,698
Ensembl chr 2:172,555,373...172,608,669
JBrowse link
G PDX1 pancreatic and duodenal homeobox 1 multiple interactions
increases expression
ISO Quercetin inhibits the reaction [Fructose results in increased expression of PDX1 protein]
Fructose results in increased expression of PDX1 mRNA; Fructose results in increased expression of PDX1 protein
CTD PMID:23533474 NCBI chr13:27,919,982...27,926,313
Ensembl chr13:27,920,000...27,926,313
JBrowse link
G PEMT phosphatidylethanolamine N-methyltransferase multiple interactions ISO [Dietary Fats co-treated with Fructose] results in increased expression of PEMT mRNA; PEMT protein promotes the reaction [AHR protein results in increased susceptibility to [Dietary Fats co-treated with Fructose]] CTD PMID:29416063 NCBI chr17:17,505,561...17,591,987
Ensembl chr17:17,505,563...17,591,708
JBrowse link
G PF4 platelet factor 4 increases expression EXP Fructose results in increased expression of PF4 mRNA CTD PMID:31655124 NCBI chr 4:73,980,811...73,982,124
Ensembl chr 4:73,980,811...73,982,027
JBrowse link
G PFKL phosphofructokinase, liver type increases expression ISO Fructose results in increased expression of PFKL mRNA CTD PMID:18346472 NCBI chr21:44,300,040...44,327,373
Ensembl chr21:44,300,051...44,327,376
JBrowse link
G PHB2 prohibitin 2 multiple interactions ISO [Fructose co-treated with bisphenol A] results in decreased expression of PHB2 protein CTD PMID:26930160 NCBI chr12:6,965,327...6,970,753
Ensembl chr12:6,965,327...6,970,780
JBrowse link
G PIK3C2G phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma multiple interactions ISO [Fructose co-treated with Oleanolic Acid] results in increased expression of PIK3C2G mRNA CTD PMID:24704288 NCBI chr12:18,242,946...18,716,861
Ensembl chr12:18,242,961...18,648,416
JBrowse link
G PIK3R1 phosphoinositide-3-kinase regulatory subunit 1 multiple interactions ISO [Fructose co-treated with Dietary Fats] results in decreased expression of PIK3R1 protein CTD PMID:32259528 NCBI chr 5:68,215,737...68,301,821
Ensembl chr 5:68,215,756...68,301,821
JBrowse link
G PKLR pyruvate kinase L/R increases expression
multiple interactions
affects expression
affects degradation
ISO Fructose results in increased expression of PKLR mRNA
Atorvastatin inhibits the reaction [Fructose results in increased expression of PKLR mRNA]; GCG protein affects the reaction [Fructose affects the degradation of PKLR mRNA]
Fructose affects the expression of PKLR mRNA
FGF21 gene mutant form inhibits the reaction [Fructose results in increased expression of PKLR mRNA]; lactisole inhibits the reaction [Fructose results in increased expression of PKLR mRNA]
CTD PMID:2193023 PMID:2414297 PMID:2824512 PMID:6526814 PMID:6759123 PMID:17786952 PMID:18346472 PMID:19053045 PMID:21122807 PMID:28123933 NCBI chr 1:155,289,293...155,301,438
Ensembl chr 1:155,289,293...155,301,438
JBrowse link
G PKM pyruvate kinase M1/2 multiple interactions ISO [Fructose co-treated with bisphenol A] results in decreased expression of PKM protein CTD PMID:26930160 NCBI chr15:72,199,029...72,231,389
Ensembl chr15:72,199,029...72,231,822
JBrowse link
G PLAT plasminogen activator, tissue type increases expression EXP Fructose results in increased expression of PLAT mRNA CTD PMID:31655124 NCBI chr 8:42,174,718...42,207,565
Ensembl chr 8:42,174,718...42,207,709
JBrowse link
G PNPLA2 patatin like phospholipase domain containing 2 increases expression ISO Fructose results in increased expression of PNPLA2 protein CTD PMID:28257781 NCBI chr11:818,914...825,573
Ensembl chr11:818,914...825,573
JBrowse link
G POMC proopiomelanocortin decreases expression ISO Fructose results in decreased expression of POMC mRNA CTD PMID:18627777 NCBI chr 2:25,160,860...25,168,580
Ensembl chr 2:25,160,853...25,168,903
JBrowse link
G PPARA peroxisome proliferator activated receptor alpha increases expression
multiple interactions
decreases expression
ISO Fructose results in increased expression of PPARA protein
[Plant Preparations co-treated with Fructose] results in increased expression of PPARA protein
Fructose results in decreased expression of PPARA protein
[dapagliflozin co-treated with Atorvastatin] inhibits the reaction [[Fructose co-treated with Dietary Fats] results in decreased expression of PPARA protein]; [Fructose co-treated with Dietary Fats] results in decreased expression of PPARA protein; Allopurinol inhibits the reaction [Fructose results in decreased expression of PPARA protein]; Atorvastatin inhibits the reaction [Fructose results in increased expression of PPARA protein]; Fenofibrate inhibits the reaction [Fructose results in decreased expression of and results in decreased activity of PPARA protein]; Fructose results in decreased expression of and results in decreased activity of PPARA protein; Quercetin inhibits the reaction [Fructose results in decreased expression of PPARA protein]; Rutin inhibits the reaction [Fructose results in decreased expression of PPARA protein]
CTD PMID:11934685 PMID:12065722 PMID:22426011 PMID:27531227 PMID:28257781 PMID:32259528 NCBI chr22:46,150,526...46,243,756
Ensembl chr22:46,150,521...46,243,756
JBrowse link
G PPARD peroxisome proliferator activated receptor delta multiple interactions
decreases response to substance
ISO [PPARD mRNA results in decreased susceptibility to Fructose] which results in decreased expression of VLDLR mRNA; Fructose inhibits the reaction [PPARD mRNA results in decreased expression of VLDLR mRNA]; Fructose promotes the reaction [PPARD gene mutant form results in increased expression of VLDLR mRNA]; Fructose promotes the reaction [PPARD gene mutant form results in increased expression of VLDLR protein]; Fructose promotes the reaction [PPARD gene mutant form results in increased phosphorylation of NFE2L2 protein] CTD PMID:29289645 NCBI chr 6:35,342,558...35,428,180
Ensembl chr 6:35,342,558...35,428,191
JBrowse link
G PPARG peroxisome proliferator activated receptor gamma increases expression
decreases activity
multiple interactions
ISO Fructose results in increased expression of PPARG mRNA
Fructose results in decreased activity of PPARG protein
[Dietary Fats co-treated with Fructose] results in decreased expression of PPARG protein; Carnitine inhibits the reaction [[Dietary Fats co-treated with Fructose] results in decreased expression of PPARG protein]; Fatty Acids, Omega-3 inhibits the reaction [[Dietary Fats co-treated with Fructose] results in decreased expression of PPARG protein]; geraniol inhibits the reaction [Fructose results in decreased activity of PPARG protein]; Metformin inhibits the reaction [[Dietary Fats co-treated with Fructose] results in decreased expression of PPARG protein]; Pioglitazone inhibits the reaction [Fructose results in decreased activity of PPARG protein]; Rosiglitazone promotes the reaction [Fructose results in increased expression of PPARG mRNA]
CTD PMID:19196556 PMID:25679220 PMID:30256492 NCBI chr 3:12,287,368...12,434,344
Ensembl chr 3:12,287,368...12,434,356
JBrowse link
G PPARGC1A PPARG coactivator 1 alpha decreases expression
multiple interactions
increases expression
EXP
ISO
Fructose results in decreased expression of PPARGC1A mRNA
[Fructose co-treated with Palmitic Acid] results in decreased expression of PPARGC1A protein; Fenofibrate inhibits the reaction [[Fructose co-treated with Palmitic Acid] results in decreased expression of PPARGC1A protein]
Fructose results in increased expression of PPARGC1A mRNA; Fructose results in increased expression of PPARGC1A protein
[Atorvastatin co-treated with dapagliflozin] inhibits the reaction [[Fructose co-treated with Dietary Fats] results in decreased expression of PPARGC1A protein]; [Fructose co-treated with Dietary Fats] results in decreased expression of PPARGC1A protein; [Ozone co-treated with Fructose] results in decreased expression of PPARGC1A mRNA; [Particulate Matter co-treated with Fructose] results in decreased expression of PPARGC1A mRNA; [Particulate Matter co-treated with Ozone co-treated with Fructose] results in decreased expression of PPARGC1A mRNA; dapagliflozin inhibits the reaction [[Fructose co-treated with Dietary Fats] results in decreased expression of PPARGC1A protein]; Rosiglitazone inhibits the reaction [Fructose results in increased expression of PPARGC1A protein]
CTD PMID:18063403 PMID:19196556 PMID:21212096 PMID:23968387 PMID:32259528 PMID:32730863 NCBI chr 4:23,792,021...24,472,905
Ensembl chr 4:23,755,041...23,904,089
JBrowse link
G PRDX6 peroxiredoxin 6 multiple interactions ISO [Fructose co-treated with bisphenol A] results in increased expression of PRDX6 protein CTD PMID:26930160 NCBI chr 1:173,477,335...173,488,815
Ensembl chr 1:173,477,330...173,488,815
JBrowse link
G PRKCA protein kinase C alpha multiple interactions ISO [Atorvastatin co-treated with dapagliflozin] inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of and results in increased phosphorylation of PRKCA protein]; [Fructose co-treated with Dietary Fats] results in increased expression of and results in increased phosphorylation of PRKCA protein CTD PMID:32259528 NCBI chr17:66,302,613...66,810,743
Ensembl chr17:66,302,613...66,810,743
JBrowse link
G PRKCQ protein kinase C theta multiple interactions
increases phosphorylation
ISO Curcumin inhibits the reaction [Fructose results in increased phosphorylation of PRKCQ protein] CTD PMID:26713546 NCBI chr10:6,393,038...6,580,646
Ensembl chr10:6,427,143...6,580,301
JBrowse link
G PRKCZ protein kinase C zeta multiple interactions ISO [Atorvastatin co-treated with dapagliflozin] inhibits the reaction [[Fructose co-treated with Dietary Fats] results in decreased expression of PRKCZ protein]; [Fructose co-treated with Dietary Fats] results in decreased expression of PRKCZ protein; dapagliflozin inhibits the reaction [[Fructose co-treated with Dietary Fats] results in decreased expression of PRKCZ protein] CTD PMID:32259528 NCBI chr 1:2,050,411...2,185,395
Ensembl chr 1:2,050,411...2,185,395
JBrowse link
G PTEN phosphatase and tensin homolog multiple interactions
increases expression
ISO tributylhexadecylphosphonium bromide inhibits the reaction [Fructose results in increased expression of PTEN protein] CTD PMID:26358169 NCBI chr10:87,863,625...87,971,930
Ensembl chr10:87,863,625...87,971,930
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 increases expression
multiple interactions
ISO Fructose results in increased expression of PTGS2 mRNA; Fructose results in increased expression of PTGS2 protein
Curcumin inhibits the reaction [Fructose results in increased expression of PTGS2 protein]; Kangen-karyu inhibits the reaction [Fructose results in increased expression of PTGS2 protein]; tributylhexadecylphosphonium bromide inhibits the reaction [Fructose results in increased expression of PTGS2 protein]
CTD PMID:14757778 PMID:17883899 PMID:26358169 PMID:26713546 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922
JBrowse link
G PTMA prothymosin alpha multiple interactions ISO PTMA protein inhibits the reaction [Fructose results in increased expression of IL1B protein]; PTMA protein inhibits the reaction [Fructose results in increased expression of IL6 protein] CTD PMID:15885234 NCBI chr 2:231,708,525...231,713,551
Ensembl chr 2:231,706,895...231,713,551
JBrowse link
G PURA purine rich element binding protein A multiple interactions ISO [Fructose co-treated with bisphenol A] results in increased expression of PURA protein CTD PMID:26930160 NCBI chr 5:140,114,109...140,125,619
Ensembl chr 5:140,107,777...140,125,619
JBrowse link
G PYCARD PYD and CARD domain containing multiple interactions
increases expression
ISO Allopurinol inhibits the reaction [Fructose results in increased expression of PYCARD protein]; Quercetin inhibits the reaction [Fructose results in increased expression of PYCARD protein]; Rutin inhibits the reaction [Fructose results in increased expression of PYCARD protein] CTD PMID:22426011 NCBI chr16:31,201,486...31,202,760
Ensembl chr16:31,201,486...31,203,450
JBrowse link
G PYY peptide YY affects expression ISO Fructose affects the expression of PYY protein CTD PMID:18627777 NCBI chr17:43,952,733...44,004,445
Ensembl chr17:43,952,738...44,004,469
JBrowse link
G RBMX RNA binding motif protein X-linked multiple interactions ISO Fructose promotes the reaction [RBMX protein binds to SREBF1 promoter] CTD PMID:17188681 NCBI chr  X:136,869,192...136,880,725
Ensembl chr  X:136,848,004...136,880,764
JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit affects localization
increases phosphorylation
decreases activity
multiple interactions
ISO Fructose affects the localization of RELA protein
Fructose results in increased phosphorylation of RELA protein
Fructose results in decreased activity of RELA protein
Allopurinol inhibits the reaction [Fructose results in increased phosphorylation of RELA protein]; Betaine inhibits the reaction [Fructose results in decreased activity of RELA protein]; galangin inhibits the reaction [Fructose affects the localization of RELA protein]; Genistein inhibits the reaction [Fructose affects the localization of RELA protein]; Metformin inhibits the reaction [Fructose results in increased phosphorylation of RELA protein]; Quercetin inhibits the reaction [Fructose results in increased phosphorylation of RELA protein]; resveratrol inhibits the reaction [Fructose results in increased phosphorylation of RELA protein]
CTD PMID:21704028 PMID:21708140 PMID:24491314 PMID:25108154 PMID:25559852 NCBI chr11:65,653,601...65,662,946
Ensembl chr11:65,653,597...65,663,090
JBrowse link
G RETN resistin decreases expression
multiple interactions
increases expression
ISO Fructose results in decreased expression of RETN mRNA
Metformin inhibits the reaction [Fructose results in increased expression of RETN protein]; resveratrol inhibits the reaction [Fructose results in increased expression of RETN protein]
CTD PMID:11741341 PMID:25108154 NCBI chr19:7,669,049...7,670,455
Ensembl chr19:7,669,049...7,670,455
JBrowse link
G RXRA retinoid X receptor alpha decreases expression ISO Fructose results in decreased expression of RXRA protein CTD PMID:28257781 NCBI chr 9:134,326,455...134,440,585
Ensembl chr 9:134,317,098...134,440,585
JBrowse link
G S100A11 S100 calcium binding protein A11 multiple interactions ISO [Fructose co-treated with bisphenol A] results in increased expression of S100A11 protein CTD PMID:26930160 NCBI chr 1:152,032,506...152,037,004
Ensembl chr 1:152,032,506...152,047,907
JBrowse link
G S100A6 S100 calcium binding protein A6 decreases expression ISO Fructose results in decreased expression of S100A6 mRNA CTD PMID:15150374 NCBI chr 1:153,534,599...153,536,049
Ensembl chr 1:153,534,599...153,536,244
JBrowse link
G SCARB1 scavenger receptor class B member 1 decreases expression ISO Fructose results in decreased expression of SCARB1 mRNA CTD PMID:19193814 NCBI chr12:124,776,856...124,863,864
Ensembl chr12:124,776,856...124,882,668
JBrowse link
G SCD stearoyl-CoA desaturase increases expression
multiple interactions
EXP
ISO
Fructose results in increased expression of SCD mRNA; Fructose results in increased expression of SCD1 mRNA
[Fructose co-treated with Copper deficiency] results in decreased expression of SCD1 mRNA; Atorvastatin inhibits the reaction [Fructose results in increased expression of SCD1 mRNA]; gadolinium chloride promotes the reaction [[Fructose co-treated with Copper deficiency] results in decreased expression of SCD1 mRNA]; Tea inhibits the reaction [Fructose results in increased expression of SCD1 mRNA]
CTD PMID:7961698 PMID:18063403 PMID:19053045 PMID:19193814 PMID:21122807 PMID:25813056 NCBI chr10:100,347,233...100,364,826
Ensembl chr10:100,347,233...100,364,826
JBrowse link
G SERPINE1 serpin family E member 1 increases secretion
increases expression
multiple interactions
ISO Fructose results in increased secretion of SERPINE1 protein
Fructose results in increased expression of SERPINE1 mRNA; Fructose results in increased expression of SERPINE1 protein
Atorvastatin inhibits the reaction [Fructose results in increased expression of SERPINE1 mRNA]; Metformin inhibits the reaction [Fructose results in increased expression of SERPINE1 protein]; Progesterone inhibits the reaction [Fructose results in increased expression of SERPINE1 mRNA]; Progesterone inhibits the reaction [Fructose results in increased expression of SERPINE1 protein]; Resveratrol inhibits the reaction [Fructose results in increased expression of SERPINE1 protein]
CTD PMID:19165636 PMID:21122807 PMID:23016136 PMID:25108154 NCBI chr 7:101,127,104...101,139,247
Ensembl chr 7:101,127,104...101,139,247
JBrowse link
G SGK1 serum/glucocorticoid regulated kinase 1 increases expression
multiple interactions
ISO Fructose results in increased expression of SGK1 mRNA
SGK1 gene affects the susceptibility to [Fructose co-treated with Sodium Chloride, Dietary]
CTD PMID:16284089 NCBI chr 6:134,169,248...134,318,112
Ensembl chr 6:134,169,248...134,318,112
JBrowse link
G SHBG sex hormone binding globulin multiple interactions
decreases expression
EXP Cerulenin inhibits the reaction [Fructose results in decreased expression of SHBG protein]; Fructose affects the reaction [NR2F1 protein binds to SHBG promoter] CTD PMID:17992261 NCBI chr17:7,614,064...7,633,372
Ensembl chr17:7,613,946...7,633,382
JBrowse link
G SI sucrase-isomaltase increases expression ISO Fructose results in increased expression of SI mRNA CTD PMID:10222385 PMID:11242478 PMID:17786952 NCBI chr 3:164,978,898...165,078,496
Ensembl chr 3:164,978,898...165,078,496
JBrowse link
G SIRT1 sirtuin 1 multiple interactions
decreases expression
increases expression
ISO
EXP
SIRT1 protein affects the reaction [Fructose results in increased expression of MYH6 mRNA]
[Fructose co-treated with Palmitic Acid] results in decreased expression of SIRT1 protein; Fenofibrate inhibits the reaction [[Fructose co-treated with Palmitic Acid] results in decreased expression of SIRT1 protein]
Fructose results in decreased expression of SIRT1 mRNA; Fructose results in decreased expression of SIRT1 protein
[6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in decreased activity of SIRT1 protein] inhibits the reaction [Fructose results in increased abundance of Cholesterol]; [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in decreased activity of SIRT1 protein] inhibits the reaction [Fructose results in increased abundance of Glucose]; [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in decreased activity of SIRT1 protein] inhibits the reaction [Fructose results in increased expression of ACACA mRNA]; [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in decreased activity of SIRT1 protein] inhibits the reaction [Fructose results in increased expression of HMGCR mRNA]; [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in decreased activity of SIRT1 protein] which results in decreased susceptibility to Fructose; [Niacinamide results in decreased activity of SIRT1 protein] inhibits the reaction [Fructose results in increased abundance of Cholesterol]; [Niacinamide results in decreased activity of SIRT1 protein] inhibits the reaction [Fructose results in increased abundance of Glucose]; [Niacinamide results in decreased activity of SIRT1 protein] inhibits the reaction [Fructose results in increased expression of ACACA mRNA]; [Niacinamide results in decreased activity of SIRT1 protein] inhibits the reaction [Fructose results in increased expression of HMGCR mRNA]; [Niacinamide results in decreased activity of SIRT1 protein] which results in decreased susceptibility to Fructose; Fructose results in increased expression of and results in increased activity of SIRT1 protein; Metformin inhibits the reaction [Fructose results in decreased expression of SIRT1 protein]; resveratrol inhibits the reaction [Fructose results in decreased expression of SIRT1 mRNA]; resveratrol inhibits the reaction [Fructose results in decreased expression of SIRT1 protein]
Fructose results in increased expression of SIRT1 protein
CTD PMID:18192211 PMID:21212096 PMID:25108154 PMID:26488877 PMID:32730863 NCBI chr10:67,884,656...67,918,390
Ensembl chr10:67,884,656...67,918,390
JBrowse link
G SLC22A1 solute carrier family 22 member 1 multiple interactions
decreases expression
ISO Allopurinol inhibits the reaction [Fructose results in decreased expression of SLC22A1 mRNA]; Allopurinol inhibits the reaction [Fructose results in decreased expression of SLC22A1 protein]; Quercetin inhibits the reaction [Fructose results in decreased expression of SLC22A1 mRNA]; Quercetin inhibits the reaction [Fructose results in decreased expression of SLC22A1 protein]; Rutin inhibits the reaction [Fructose results in decreased expression of SLC22A1 mRNA]; Rutin inhibits the reaction [Fructose results in decreased expression of SLC22A1 protein]
Fructose results in decreased expression of SLC22A1 mRNA; Fructose results in decreased expression of SLC22A1 protein
CTD PMID:19605544 NCBI chr 6:160,121,808...160,160,590
Ensembl chr 6:160,121,815...160,158,718
JBrowse link
G SLC22A12 solute carrier family 22 member 12 multiple interactions
increases expression
ISO Allopurinol inhibits the reaction [Fructose results in increased expression of SLC22A12 mRNA]; Allopurinol inhibits the reaction [Fructose results in increased expression of SLC22A12 protein]; Quercetin inhibits the reaction [Fructose results in increased expression of SLC22A12 mRNA]; Quercetin inhibits the reaction [Fructose results in increased expression of SLC22A12 protein]; Rutin inhibits the reaction [Fructose results in increased expression of SLC22A12 mRNA]; Rutin inhibits the reaction [Fructose results in increased expression of SLC22A12 protein]
Fructose results in increased expression of SLC22A12 mRNA; Fructose results in increased expression of SLC22A12 protein
CTD PMID:19605544 NCBI chr11:64,591,219...64,603,250
Ensembl chr11:64,590,641...64,602,353
JBrowse link
G SLC22A2 solute carrier family 22 member 2 decreases expression
multiple interactions
ISO Fructose results in decreased expression of SLC22A2 mRNA; Fructose results in decreased expression of SLC22A2 protein
Allopurinol inhibits the reaction [Fructose results in decreased expression of SLC22A2 mRNA]; Allopurinol inhibits the reaction [Fructose results in decreased expression of SLC22A2 protein]; Quercetin inhibits the reaction [Fructose results in decreased expression of SLC22A2 mRNA]; Quercetin inhibits the reaction [Fructose results in decreased expression of SLC22A2 protein]; Rutin inhibits the reaction [Fructose results in decreased expression of SLC22A2 mRNA]; Rutin inhibits the reaction [Fructose results in decreased expression of SLC22A2 protein]
CTD PMID:19605544 NCBI chr 6:160,216,755...160,258,821
Ensembl chr 6:160,171,061...160,277,638
JBrowse link
G SLC22A5 solute carrier family 22 member 5 decreases expression
multiple interactions
ISO Fructose results in decreased expression of SLC22A5 protein
Allopurinol inhibits the reaction [Fructose results in decreased expression of SLC22A5 protein]; Quercetin inhibits the reaction [Fructose results in decreased expression of SLC22A5 protein]
CTD PMID:22426011 NCBI chr 5:132,369,704...132,395,614
Ensembl chr 5:132,369,710...132,395,613
JBrowse link
G SLC22A6 solute carrier family 22 member 6 decreases expression
multiple interactions
ISO Fructose results in decreased expression of SLC22A6 mRNA; Fructose results in decreased expression of SLC22A6 protein
Allopurinol inhibits the reaction [Fructose results in decreased expression of SLC22A6 mRNA]; Allopurinol inhibits the reaction [Fructose results in decreased expression of SLC22A6 protein]; Quercetin inhibits the reaction [Fructose results in decreased expression of SLC22A6 mRNA]; Quercetin inhibits the reaction [Fructose results in decreased expression of SLC22A6 protein]; Rutin inhibits the reaction [Fructose results in decreased expression of SLC22A6 mRNA]; Rutin inhibits the reaction [Fructose results in decreased expression of SLC22A6 protein]
CTD PMID:19605544 NCBI chr11:62,976,597...62,984,967
Ensembl chr11:62,936,385...62,984,967
JBrowse link
G SLC25A5 solute carrier family 25 member 5 multiple interactions ISO [Fructose co-treated with bisphenol A] results in decreased expression of SLC25A5 protein CTD PMID:26930160 NCBI chr  X:119,468,444...119,471,396
Ensembl chr  X:119,468,422...119,471,396
JBrowse link
G SLC27A2 solute carrier family 27 member 2 decreases expression ISO Fructose results in decreased expression of SLC27A2 protein CTD PMID:28257781 NCBI chr15:50,182,196...50,236,385
Ensembl chr15:50,182,196...50,236,385
JBrowse link
G SLC2A11 solute carrier family 2 member 11 increases transport EXP SLC2A11 protein results in increased transport of Fructose CTD PMID:17710649 NCBI chr22:23,856,934...23,886,312
Ensembl chr22:23,856,703...23,886,309
JBrowse link
G SLC2A2 solute carrier family 2 member 2 multiple interactions
increases expression
increases transport
EXP
ISO
Fructose inhibits the reaction [SLC2A2 protein results in increased transport of Deoxyglucose]; Glucose inhibits the reaction [SLC2A2 protein results in increased transport of Fructose]; Maltose inhibits the reaction [SLC2A2 protein results in increased transport of Fructose]
Fructose results in increased expression of SLC2A2 mRNA
Dactinomycin inhibits the reaction [Fructose results in increased expression of SLC2A2 mRNA]
Fructose results in increased expression of and affects the localization of SLC2A2 protein
CTD PMID:1727734 PMID:8457197 PMID:10222385 PMID:12787936 PMID:12937289 PMID:17710649 PMID:17786952 NCBI chr 3:170,996,341...171,026,721
Ensembl chr 3:170,996,347...171,026,743
JBrowse link
G SLC2A4 solute carrier family 2 member 4 decreases expression
multiple interactions
increases expression
EXP
ISO
Fructose results in decreased expression of SLC2A4 mRNA
[Dietary Fats co-treated with Fructose] results in decreased expression of SLC2A4 protein; Carnitine inhibits the reaction [[Dietary Fats co-treated with Fructose] results in decreased expression of SLC2A4 protein]; Fatty Acids, Omega-3 inhibits the reaction [[Dietary Fats co-treated with Fructose] results in decreased expression of SLC2A4 protein]; Metformin inhibits the reaction [[Dietary Fats co-treated with Fructose] results in decreased expression of SLC2A4 protein]
Fructose results in increased expression of SLC2A4 mRNA
CTD PMID:15111496 PMID:18063403 PMID:30256492 NCBI chr17:7,281,718...7,288,257
Ensembl chr17:7,281,718...7,288,257
JBrowse link
G SLC2A5 solute carrier family 2 member 5 multiple interactions
increases activity
increases expression
increases transport
increases uptake
affects expression
EXP
ISO
[Fructose results in increased abundance of Cyclic AMP] which results in increased stability of SLC2A5 mRNA; Colforsin promotes the reaction [Fructose results in increased expression of SLC2A5 mRNA]; Fructose promotes the reaction [PAIP2 protein binds to SLC2A5 3' UTR]
Fructose results in increased activity of SLC2A5 protein
SLC2A5 protein results in increased transport of Fructose
Fructose results in increased expression of SLC2A5 mRNA; Fructose results in increased expression of SLC2A5 protein
SLC2A5 protein results in increased uptake of Fructose
Fructose affects the expression of SLC2A5 mRNA
Fructose analog results in increased expression of SLC2A5 mRNA; Fructose results in increased expression of SLC2A5 mRNA; Fructose results in increased expression of SLC2A5 protein
1-((1-O-octadecyl-2-O-methylglycero)phospho)-3-deoxy-myo-inositol inhibits the reaction [Fructose results in increased expression of and results in increased activity of SLC2A5 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Fructose results in increased expression of and results in increased activity of SLC2A5 protein]; [[Colforsin results in increased abundance of Cyclic AMP] which results in increased expression of SLC2A5 protein] which results in increased uptake of Fructose; [Triiodothyronine co-treated with Fructose] results in increased expression of SLC2A5 mRNA; Cycloheximide inhibits the reaction [Fructose promotes the reaction [SLC2A5 protein results in increased uptake of Fructose]]; Dactinomycin inhibits the reaction [Fructose promotes the reaction [SLC2A5 protein results in increased uptake of Fructose]]; Dactinomycin inhibits the reaction [Fructose results in increased expression of SLC2A5 mRNA]; Dexamethasone promotes the reaction [Fructose results in increased activity of SLC2A5 protein]; Dexamethasone promotes the reaction [Fructose results in increased expression of SLC2A5 mRNA]; Fructose analog results in increased activity of [SLC2A5 protein results in increased uptake of Fructose]; Fructose promotes the reaction [SLC2A5 protein results in increased transport of Fructose]; Fructose promotes the reaction [SLC2A5 protein results in increased uptake of Fructose]; Fructose results in increased expression of and results in increased activity of SLC2A5 protein; Mifepristone inhibits the reaction [Dexamethasone promotes the reaction [Fructose results in increased activity of SLC2A5 protein]]; Mifepristone inhibits the reaction [Dexamethasone promotes the reaction [Fructose results in increased expression of SLC2A5 mRNA]]; Vanadates inhibits the reaction [Fructose results in increased activity of SLC2A5 protein]; Vanadates inhibits the reaction [Fructose results in increased expression of SLC2A5 mRNA]; wortmannin inhibits the reaction [Fructose results in increased expression of and results in increased activity of SLC2A5 protein]
lactisole inhibits the reaction [Fructose results in increased expression of SLC2A5 mRNA]
CTD PMID:1634504 PMID:8037665 PMID:8048533 PMID:8404647 PMID:8554516 PMID:9078534 PMID:9124564 PMID:9486174 PMID:9606981 PMID:10222385 PMID:10554124 PMID:11123204 PMID:11242478 PMID:11518678 PMID:12031501 PMID:12820898 PMID:12937289 PMID:15150374 PMID:15226456 PMID:15457374 PMID:15691865 PMID:16581195 PMID:16920846 PMID:16960373 PMID:17485832 PMID:17710649 PMID:17786952 PMID:18400728 PMID:18556366 PMID:19907007 NCBI chr 1:9,035,106...9,072,259
Ensembl chr 1:9,035,106...9,088,478
JBrowse link
G SLC2A7 solute carrier family 2 member 7 increases transport EXP SLC2A7 protein results in increased transport of Fructose CTD PMID:15033637 PMID:17710649 NCBI chr 1:8,992,534...9,026,423
Ensembl chr 1:9,002,973...9,026,423
JBrowse link
G SLC2A9 solute carrier family 2 member 9 increases transport
multiple interactions
increases expression
EXP
ISO
SLC2A9 protein results in increased transport of Fructose
Allopurinol inhibits the reaction [Fructose results in increased expression of SLC2A9 mRNA SNP]; Allopurinol inhibits the reaction [Fructose results in increased expression of SLC2A9 protein SNP]; Quercetin inhibits the reaction [Fructose results in increased expression of SLC2A9 mRNA SNP]; Quercetin inhibits the reaction [Fructose results in increased expression of SLC2A9 protein SNP]; Rutin inhibits the reaction [Fructose results in increased expression of SLC2A9 mRNA SNP]; Rutin inhibits the reaction [Fructose results in increased expression of SLC2A9 protein SNP]
Fructose results in increased expression of SLC2A9 mRNA SNP; Fructose results in increased expression of SLC2A9 protein SNP
Fructose promotes the reaction [SLC2A9 protein alternative form results in increased transport of Uric Acid]
CTD PMID:17710649 PMID:18842065 PMID:19605544 NCBI chr 4:9,771,125...10,040,270
Ensembl chr 4:9,771,153...10,054,936
JBrowse link
G SLC31A1 solute carrier family 31 member 1 multiple interactions ISO Fructose inhibits the reaction [Copper deficiency results in increased expression of SLC31A1 protein] CTD PMID:21781943 NCBI chr 9:113,221,544...113,264,492
Ensembl chr 9:113,221,544...113,264,492
JBrowse link
G SLC34A2 solute carrier family 34 member 2 decreases expression
multiple interactions
affects expression
ISO Fructose results in decreased expression of SLC34A2 mRNA
tungstate promotes the reaction [Fructose results in decreased expression of SLC34A2 mRNA]; Vanadates promotes the reaction [Fructose results in decreased expression of SLC34A2 mRNA]
Fructose affects the expression of SLC34A2 mRNA
CTD PMID:15150374 PMID:18400728 NCBI chr 4:25,655,851...25,678,748
Ensembl chr 4:25,648,011...25,678,748
JBrowse link
G SLC37A4 solute carrier family 37 member 4 increases expression ISO Fructose results in increased expression of SLC37A4 mRNA CTD PMID:16920846 NCBI chr11:119,024,112...119,030,877
Ensembl chr11:119,024,114...119,030,906
JBrowse link
G SLC46A1 solute carrier family 46 member 1 multiple interactions ISO [Folic Acid affects the susceptibility to Fructose] which affects the expression of SLC46A1 mRNA CTD PMID:31612177 NCBI chr17:28,394,642...28,406,630
Ensembl chr17:28,394,642...28,407,197
JBrowse link
G SLC5A1 solute carrier family 5 member 1 multiple interactions
increases expression
ISO lactisole inhibits the reaction [Fructose results in increased expression of SLC5A1 mRNA]
Fructose results in increased expression of SLC5A1 mRNA; Fructose results in increased expression of SLC5A1 protein
CTD PMID:8048533 PMID:10222385 PMID:11242478 PMID:12937289 PMID:17786952 NCBI chr22:32,043,050...32,113,029
Ensembl chr22:32,043,261...32,113,029
JBrowse link
G SLC8A1 solute carrier family 8 member A1 multiple interactions ISO [Fructose co-treated with Dietary Fats] results in decreased expression of SLC8A1 mRNA; troxerutin inhibits the reaction [[Fructose co-treated with Dietary Fats] results in decreased expression of SLC8A1 mRNA] CTD PMID:28916335 NCBI chr 2:40,097,270...40,512,435
Ensembl chr 2:40,097,270...40,611,053
JBrowse link
G SOAT2 sterol O-acyltransferase 2 decreases expression ISO Fructose results in decreased expression of SOAT2 mRNA CTD PMID:19193814 NCBI chr12:53,103,486...53,124,535
Ensembl chr12:53,103,486...53,124,535
JBrowse link
G SOCS3 suppressor of cytokine signaling 3 increases expression
multiple interactions
ISO Fructose results in increased expression of SOCS3 mRNA; Fructose results in increased expression of SOCS3 protein
[Fenofibrate co-treated with resveratrol] inhibits the reaction [Fructose results in increased expression of SOCS3 mRNA]; Fenofibrate inhibits the reaction [Fructose results in increased expression of SOCS3 mRNA]; Quercetin inhibits the reaction [Fructose results in increased expression of SOCS3 protein]; resveratrol inhibits the reaction [Fructose results in increased expression of SOCS3 mRNA]; Rutin inhibits the reaction [Fructose results in increased expression of SOCS3 protein]
CTD PMID:21122807 PMID:22426011 PMID:23533474 PMID:26973390 NCBI chr17:78,356,778...78,360,925
Ensembl chr17:78,356,778...78,360,077
JBrowse link
G SOD1 superoxide dismutase 1 affects binding
decreases expression
multiple interactions
decreases activity
increases activity
EXP
ISO
Fructose binds to SOD1 protein mutant form
Fructose results in decreased expression of SOD1 mRNA; Fructose results in decreased expression of SOD1 protein
[Fructose co-treated with Copper deficiency] results in decreased expression of SOD1 protein
Fructose results in decreased activity of SOD1 protein
Fructose results in increased activity of SOD1 protein
Fructose promotes the reaction [SOD1 protein mutant form results in increased chemical synthesis of Hydrogen Peroxide]
CTD PMID:11817707 PMID:12626432 PMID:16815490 PMID:20470786 PMID:21781943 NCBI chr21:31,659,693...31,668,931
Ensembl chr21:31,659,666...31,668,931
JBrowse link
G SORD sorbitol dehydrogenase multiple interactions
increases glycation
ISO
EXP
[Fructose results in increased glycation of SORD protein] which results in decreased activity of SORD protein
[SORD protein results in increased metabolism of Sorbitol] which results in increased abundance of Fructose
CTD PMID:8761460 PMID:32367058 NCBI chr15:45,023,195...45,077,185
Ensembl chr15:45,023,147...45,077,185
JBrowse link
G SREBF1 sterol regulatory element binding transcription factor 1 multiple interactions
increases expression
affects localization
affects response to substance
ISO Phenylbutyrates inhibits the reaction [Fructose affects the localization of SREBF1 protein alternative form]; Phenylbutyrates inhibits the reaction [Fructose results in increased expression of SREBF1 mRNA]; SCD1 affects the reaction [Fructose results in increased expression of SREBF1 protein]; SCD1 gene mutant form inhibits the reaction [Fructose results in increased expression of SREBF1 mRNA]; SCD1 gene mutant form inhibits the reaction [Fructose results in increased expression of SREBF1 protein]; Triolein inhibits the reaction [SCD1 gene mutant form inhibits the reaction [Fructose results in increased expression of SREBF1 mRNA]]; Triolein inhibits the reaction [SCD1 gene mutant form inhibits the reaction [Fructose results in increased expression of SREBF1 protein]]
Fructose results in increased expression of SREBF1 mRNA; Fructose results in increased expression of SREBF1 protein
[Atorvastatin co-treated with dapagliflozin] inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of SREBF1 protein]; [Fenofibrate co-treated with Resveratrol] inhibits the reaction [Fructose results in increased expression of SREBF1 mRNA]; [Fructose co-treated with Copper deficiency] results in increased expression of SREBF1 protein; [Fructose co-treated with Dietary Fats] results in increased expression of SREBF1 protein; Atorvastatin inhibits the reaction [Fructose results in increased activity of SREBF1 protein]; dapagliflozin inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of SREBF1 protein]; Fructose promotes the reaction [RBMX protein binds to SREBF1 promoter]; Fructose results in increased expression of and results in increased activity of SREBF1 protein; gadolinium chloride inhibits the reaction [[Fructose co-treated with Copper deficiency] results in increased expression of SREBF1 protein]; Resveratrol inhibits the reaction [Fructose results in increased expression of SREBF1 mRNA]; Rosiglitazone inhibits the reaction [Fructose results in increased expression of SREBF1 mRNA]; Tea inhibits the reaction [Fructose results in increased expression of SREBF1 mRNA]
SREBF1 promoter SNP affects the susceptibility to Fructose
CTD PMID:10913129 PMID:11934685 PMID:15066988 PMID:15123654 PMID:17188681 PMID:18346472 PMID:19053045 PMID:19193814 PMID:19196556 PMID:19799862 PMID:22698815 PMID:25813056 PMID:26973390 PMID:32259528 NCBI chr17:17,811,334...17,837,017
Ensembl chr17:17,810,399...17,837,002
JBrowse link
G STAT3 signal transducer and activator of transcription 3 increases phosphorylation
decreases phosphorylation
multiple interactions
ISO Fructose results in increased phosphorylation of STAT3 protein
Fructose results in decreased phosphorylation of STAT3 protein
Quercetin inhibits the reaction [Fructose results in decreased phosphorylation of STAT3 protein]; Quercetin inhibits the reaction [Fructose results in increased phosphorylation of STAT3 protein]; Rutin inhibits the reaction [Fructose results in increased phosphorylation of STAT3 protein]
CTD PMID:22426011 PMID:23533474 NCBI chr17:42,313,324...42,388,502
Ensembl chr17:42,313,324...42,388,540
JBrowse link
G STEAP4 STEAP4 metalloreductase multiple interactions ISO [Dietary Fats co-treated with Fructose] results in increased expression of STEAP4 mRNA CTD PMID:19632207 NCBI chr 7:88,270,892...88,306,894
Ensembl chr 7:88,270,892...88,306,894
JBrowse link
G TFAM transcription factor A, mitochondrial increases expression ISO Fructose results in increased expression of TFAM protein CTD PMID:11934685 NCBI chr10:58,385,409...58,399,220
Ensembl chr10:58,385,345...58,399,220
JBrowse link
G TGFB1 transforming growth factor beta 1 decreases expression
multiple interactions
increases expression
ISO Fructose results in decreased expression of TGFB1 mRNA
[FGF21 gene mutant form results in increased susceptibility to Fructose] which results in increased expression of TGFB1 mRNA
Fructose results in increased expression of TGFB1 mRNA; Fructose results in increased expression of TGFB1 protein
[Fenofibrate co-treated with Resveratrol] inhibits the reaction [Fructose results in increased expression of TGFB1 mRNA]; [Streptozocin co-treated with Fructose] results in increased expression of and results in increased secretion of TGFB1 protein; betanin inhibits the reaction [Fructose results in increased expression of TGFB1 protein]; dapagliflozin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of and results in increased secretion of TGFB1 protein]; dapagliflozin promotes the reaction [Metformin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of and results in increased secretion of TGFB1 protein]]; Fenofibrate inhibits the reaction [Fructose results in increased expression of TGFB1 mRNA]; galangin inhibits the reaction [Fructose results in increased expression of TGFB1 protein]; Genistein inhibits the reaction [Fructose results in increased expression of TGFB1 protein]; Metformin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of and results in increased secretion of TGFB1 protein]; Resveratrol inhibits the reaction [Fructose results in increased expression of TGFB1 mRNA]
CTD PMID:15150374 PMID:21704028 PMID:21708140 PMID:25559852 PMID:26973390 PMID:28123933 PMID:30551545 NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922
JBrowse link
G TGFB2 transforming growth factor beta 2 multiple interactions ISO [FGF21 gene mutant form results in increased susceptibility to Fructose] which results in increased expression of TGFB2 mRNA CTD PMID:28123933 NCBI chr 1:218,345,336...218,444,619
Ensembl chr 1:218,345,336...218,444,619
JBrowse link
G TH tyrosine hydroxylase increases expression ISO Fructose results in increased expression of TH mRNA CTD PMID:16843071 NCBI chr11:2,163,929...2,174,081
Ensembl chr11:2,163,929...2,171,815
JBrowse link
G THRSP thyroid hormone responsive multiple interactions ISO Fructose inhibits the reaction [Streptozocin results in decreased expression of THRSP mRNA] CTD PMID:2177838 NCBI chr11:78,063,861...78,068,351
Ensembl chr11:78,063,861...78,068,351
JBrowse link
G TLR4 toll like receptor 4 multiple interactions
increases expression
ISO [gadolinium chloride co-treated with Fructose co-treated with Copper deficiency] results in decreased expression of TLR4 mRNA
Fructose results in increased expression of TLR4 protein
[Fructose co-treated with Ethanol] results in increased expression of TLR4 mRNA
CTD PMID:25813056 PMID:26858005 PMID:31672515 NCBI chr 9:117,704,403...117,724,735
Ensembl chr 9:117,704,175...117,724,735
JBrowse link
G TNF tumor necrosis factor multiple interactions
increases secretion
increases expression
ISO 2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [caryophyllene inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of TNF protein]]; [Dietary Fats co-treated with Fructose] results in increased expression of TNF protein; [Fenofibrate co-treated with Resveratrol] inhibits the reaction [Fructose results in increased expression of and results in increased secretion of TNF protein]; [gadolinium chloride co-treated with Fructose co-treated with Copper deficiency] results in decreased expression of TNF mRNA; [Particulate Matter co-treated with Ozone] promotes the reaction [Fructose results in increased expression of TNF mRNA]; [Streptozocin co-treated with Fructose] results in increased expression of and results in increased secretion of TNF protein; Allopurinol inhibits the reaction [Fructose results in increased expression of TNF protein]; caffeic acid phenethyl ester inhibits the reaction [Fructose results in increased expression of TNF protein]; caryophyllene inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of TNF protein]; Curcumin inhibits the reaction [Fructose results in increased expression of TNF protein]; dapagliflozin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of and results in increased secretion of TNF protein]; dapagliflozin promotes the reaction [Metformin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of and results in increased secretion of TNF protein]]; Fenofibrate inhibits the reaction [Fructose results in increased expression of and results in increased secretion of TNF protein]; Fructose inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of TNF protein]; Fructose results in increased expression of and results in increased secretion of TNF protein; galangin inhibits the reaction [Fructose results in increased expression of TNF mRNA]; galangin inhibits the reaction [Fructose results in increased expression of TNF protein]; Genistein inhibits the reaction [Fructose results in increased expression of TNF protein]; geraniol inhibits the reaction [Fructose results in increased secretion of TNF protein]; iodopravadoline inhibits the reaction [caryophyllene inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of TNF protein]]; Metformin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of and results in increased secretion of TNF protein]; Metformin inhibits the reaction [Fructose results in increased expression of TNF protein]; Ozone promotes the reaction [Fructose results in increased expression of TNF mRNA]; Particulate Matter promotes the reaction [Fructose results in increased expression of TNF mRNA]; Pioglitazone inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of TNF protein]; Pioglitazone inhibits the reaction [Fructose results in increased secretion of TNF protein]; Quercetin inhibits the reaction [Fructose results in increased expression of TNF protein]; Resveratrol inhibits the reaction [Fructose results in increased expression of and results in increased secretion of TNF protein]; Resveratrol inhibits the reaction [Fructose results in increased expression of TNF protein]; Rutin inhibits the reaction [Fructose results in increased expression of TNF protein]; tributylhexadecylphosphonium bromide inhibits the reaction [Fructose results in increased expression of TNF protein]
Fructose promotes the reaction [Ethanol results in increased expression of TNF mRNA]
Fructose results in increased expression of TNF mRNA; Fructose results in increased expression of TNF protein
CTD PMID:10090849 PMID:21704028 PMID:21708140 PMID:22426011 PMID:23968387 PMID:24508943 PMID:25108154 PMID:25679220 PMID:25813056 PMID:26358169 PMID:26713546 PMID:26858005 PMID:26973390 PMID:27531227 PMID:28257781 PMID:30343038 PMID:30551545 PMID:31672515 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
JBrowse link
G TRAF6 TNF receptor associated factor 6 multiple interactions ISO Fructose inhibits the reaction [Ethanol results in increased expression of TRAF6 protein]; Fructose promotes the reaction [Ethanol results in increased expression of TRAF6 mRNA] CTD PMID:26858005 NCBI chr11:36,483,769...36,510,313
Ensembl chr11:36,483,769...36,510,272
JBrowse link
G TRAP1 TNF receptor associated protein 1 multiple interactions
decreases expression
ISO [Fructose co-treated with bisphenol A] results in increased expression of TRAP1 protein
Fructose results in decreased expression of TRAP1 protein
CTD PMID:26930160 NCBI chr16:3,658,037...3,717,524
Ensembl chr16:3,651,639...3,717,553
JBrowse link
G TRIB3 tribbles pseudokinase 3 increases expression
multiple interactions
ISO Fructose results in increased expression of TRIB3 mRNA
Phenylbutyrates inhibits the reaction [Fructose results in increased expression of TRIB3 mRNA]
CTD PMID:18497449 PMID:22698815 NCBI chr20:380,760...397,559
Ensembl chr20:362,835...397,559
JBrowse link
G TTR transthyretin multiple interactions ISO [Fructose co-treated with bisphenol A] results in increased expression of TTR protein CTD PMID:26930160 NCBI chr18:31,591,877...31,598,821
Ensembl chr18:31,557,009...31,598,833
JBrowse link
G TXNIP thioredoxin interacting protein increases expression
multiple interactions
ISO Fructose results in increased expression of TXNIP protein
Allopurinol inhibits the reaction [Fructose results in increased expression of TXNIP protein]; Quercetin inhibits the reaction [Fructose results in increased expression of TXNIP protein]
CTD PMID:24491314 NCBI chr 1:145,992,435...145,996,579
Ensembl chr 1:145,992,435...145,996,579
JBrowse link
G UCP1 uncoupling protein 1 multiple interactions
decreases expression
ISO Fructose promotes the reaction [[Ozone co-treated with Particulate Matter] results in decreased expression of UCP1 mRNA]; Fructose promotes the reaction [Ozone results in decreased expression of UCP1 mRNA]; Fructose promotes the reaction [Particulate Matter results in decreased expression of UCP1 mRNA]
Fructose results in decreased expression of UCP1 mRNA
CTD PMID:23968387 NCBI chr 4:140,555,770...140,568,961
Ensembl chr 4:140,559,431...140,568,961
JBrowse link
G UCP3 uncoupling protein 3 increases expression ISO Fructose results in increased expression of UCP3 protein CTD PMID:11934685 NCBI chr11:74,000,277...74,009,085
Ensembl chr11:74,000,277...74,009,085
JBrowse link
G VCAM1 vascular cell adhesion molecule 1 increases expression
multiple interactions
ISO
EXP
Fructose results in increased expression of VCAM1 mRNA
2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [caryophyllene inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of VCAM1 protein]]; [Dietary Fats co-treated with Fructose] results in increased expression of VCAM1 protein; caryophyllene inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of VCAM1 protein]; iodopravadoline inhibits the reaction [caryophyllene inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of VCAM1 protein]]; Pioglitazone inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of VCAM1 protein]
CTD PMID:17587757 PMID:30343038 PMID:31655124 NCBI chr 1:100,719,742...100,739,045
Ensembl chr 1:100,719,742...100,739,045
JBrowse link
G VCL vinculin multiple interactions
decreases expression
ISO [Fructose co-treated with bisphenol A] results in decreased expression of VCL protein
Fructose results in decreased expression of VCL protein
CTD PMID:26930160 NCBI chr10:73,998,116...74,121,363
Ensembl chr10:73,995,193...74,121,363
JBrowse link
G VEGFA vascular endothelial growth factor A multiple interactions ISO [bisphenol A co-treated with Fructose] results in increased expression of VEGFA mRNA CTD PMID:27622962 NCBI chr 6:43,770,209...43,786,487
Ensembl chr 6:43,770,184...43,786,487
JBrowse link
G VLDLR very low density lipoprotein receptor multiple interactions ISO [PPARD mRNA results in decreased susceptibility to Fructose] which results in decreased expression of VLDLR mRNA; Fructose inhibits the reaction [PPARD mRNA results in decreased expression of VLDLR mRNA]; Fructose promotes the reaction [PPARD gene mutant form results in increased expression of VLDLR mRNA]; Fructose promotes the reaction [PPARD gene mutant form results in increased expression of VLDLR protein] CTD PMID:29289645 NCBI chr 9:2,621,786...2,660,056
Ensembl chr 9:2,621,182...2,660,056
JBrowse link
G VNN1 vanin 1 multiple interactions ISO [Streptozocin co-treated with Fructose] results in increased expression of VNN1 mRNA; dapagliflozin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of VNN1 mRNA]; Metformin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of VNN1 mRNA] CTD PMID:30551545 NCBI chr 6:132,680,849...132,714,055
Ensembl chr 6:132,680,849...132,714,055
JBrowse link
G XBP1 X-box binding protein 1 affects localization ISO Fructose affects the localization of XBP1 protein CTD PMID:22698815 NCBI chr22:28,794,560...28,800,569
Ensembl chr22:28,794,555...28,800,597
JBrowse link
G XDH xanthine dehydrogenase multiple interactions
increases activity
EXP
ISO
Fructose promotes the reaction [XDH protein results in increased chemical synthesis of Uric Acid]; XDH protein promotes the reaction [Fructose results in increased abundance of Reactive Oxygen Species]
Glutamine inhibits the reaction [Fructose results in increased activity of XDH protein]
CTD PMID:19158351 PMID:31233715 NCBI chr 2:31,334,320...31,414,777
Ensembl chr 2:31,334,321...31,414,742
JBrowse link
G YBX3 Y-box binding protein 3 multiple interactions ISO [Fructose co-treated with bisphenol A] results in increased expression of YBX3 protein CTD PMID:26930160 NCBI chr12:10,699,084...10,723,442
Ensembl chr12:10,699,089...10,723,323
JBrowse link
keto-D-fructose 1,6-bisphosphate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GAPDH glyceraldehyde-3-phosphate dehydrogenase multiple interactions ISO [GAPDH protein co-treated with fructose-1,6-diphosphate co-treated with NAD] results in increased chemical synthesis of sodium arsenite; [GAPDH protein co-treated with fructose-1,6-diphosphate co-treated with NAD] results in increased reduction of sodium arsenate analog; heptelidic acid inhibits the reaction [[GAPDH protein co-treated with fructose-1,6-diphosphate co-treated with NAD] results in increased reduction of sodium arsenate analog] CTD PMID:15788719 NCBI chr12:6,534,517...6,538,371
Ensembl chr12:6,534,512...6,538,374
JBrowse link
G IDH2 isocitrate dehydrogenase (NADP(+)) 2 increases abundance
multiple interactions
ISO IDH2 protein mutant form results in increased abundance of fructose-1,6-diphosphate
Triazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of fructose-1,6-diphosphate]
CTD PMID:27469509 NCBI chr15:90,083,045...90,102,468
Ensembl chr15:90,083,045...90,102,477
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions ISO fructose-1,6-diphosphate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein] CTD PMID:22227475 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions ISO fructose-1,6-diphosphate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein] CTD PMID:22227475 NCBI chr16:30,114,105...30,123,309
Ensembl chr16:30,114,105...30,123,506
JBrowse link
G NOS2 nitric oxide synthase 2 multiple interactions
decreases degradation
ISO fructose-1,6-diphosphate inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; fructose-1,6-diphosphate inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]
fructose-1,6-diphosphate results in decreased degradation of NOS2 mRNA
CTD PMID:22227475 NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529
JBrowse link
psicose term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCL2 C-C motif chemokine ligand 2 multiple interactions EXP psicose inhibits the reaction [Glucose results in increased expression of CCL2 mRNA]; psicose inhibits the reaction [Glucose results in increased expression of CCL2 protein] CTD PMID:17655880 NCBI chr17:34,255,285...34,257,203
Ensembl chr17:34,255,218...34,257,203
JBrowse link
royal jelly term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BCL2 BCL2 apoptosis regulator multiple interactions ISO royal jelly inhibits the reaction [Nicotine results in decreased expression of BCL2 mRNA] CTD PMID:30896085 NCBI chr18:63,123,346...63,320,280
Ensembl chr18:63,123,346...63,320,128
JBrowse link
G CASP3 caspase 3 multiple interactions ISO royal jelly inhibits the reaction [Nicotine results in increased expression of CASP3 mRNA] CTD PMID:30896085 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,649,509
JBrowse link
G CAT catalase multiple interactions ISO royal jelly inhibits the reaction [Cisplatin results in decreased activity of CAT protein]
royal jelly inhibits the reaction [Nicotine results in decreased activity of CAT protein]
CTD PMID:20369241 PMID:30896085 NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060
JBrowse link
G ESR1 estrogen receptor 1 multiple interactions
affects binding
increases activity
EXP Estradiol inhibits the reaction [royal jelly binds to ESR1 protein]; royal jelly binds to and results in increased activity of ESR1 protein; royal jelly inhibits the reaction [Estradiol binds to ESR1 protein]
royal jelly results in increased activity of ESR1 protein
CTD PMID:15946813 PMID:17287592 NCBI chr 6:151,654,148...152,129,619
Ensembl chr 6:151,656,691...152,129,619
JBrowse link
G ESR2 estrogen receptor 2 multiple interactions
affects binding
EXP Estradiol inhibits the reaction [royal jelly binds to ESR2 protein]; royal jelly binds to and results in increased activity of ESR2 protein; royal jelly inhibits the reaction [Estradiol binds to ESR2 protein] CTD PMID:15946813 PMID:17287592 NCBI chr14:64,226,707...64,338,631
Ensembl chr14:64,084,232...64,338,112
JBrowse link
G PCNA proliferating cell nuclear antigen multiple interactions ISO royal jelly inhibits the reaction [Nicotine results in decreased expression of PCNA protein] CTD PMID:30896085 NCBI chr20:5,114,953...5,126,622
Ensembl chr20:5,114,953...5,126,626
JBrowse link
G TFF1 trefoil factor 1 increases expression EXP royal jelly results in increased expression of TFF1 mRNA CTD PMID:15946813 NCBI chr21:42,362,282...42,366,535
Ensembl chr21:42,362,282...42,366,535
JBrowse link
G TP53 tumor protein p53 multiple interactions ISO royal jelly inhibits the reaction [Nicotine results in increased expression of TRP53 mRNA] CTD PMID:30896085 NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,538
JBrowse link
G VEGFA vascular endothelial growth factor A increases expression EXP
ISO
royal jelly results in increased expression of VEGFA mRNA CTD PMID:15946813 PMID:17287592 NCBI chr 6:43,770,209...43,786,487
Ensembl chr 6:43,770,184...43,786,487
JBrowse link
sedoheptulose 1,7-bisphosphate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G IDH2 isocitrate dehydrogenase (NADP(+)) 2 increases abundance
multiple interactions
ISO IDH2 protein mutant form results in increased abundance of sedoheptulose 1,7-bisphosphate
Triazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of sedoheptulose 1,7-bisphosphate]
CTD PMID:27469509 NCBI chr15:90,083,045...90,102,468
Ensembl chr15:90,083,045...90,102,477
JBrowse link
sorbose term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G OAT ornithine aminotransferase multiple interactions
decreases activity
ISO Sorbose inhibits the reaction [Cyclic AMP results in increased activity of OAT protein]
Sorbose results in decreased activity of OAT protein
CTD PMID:2827574 NCBI chr10:124,397,303...124,418,923
Ensembl chr10:124,397,303...124,418,976
JBrowse link
tagatose term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCL2 C-C motif chemokine ligand 2 increases secretion EXP tagatose results in increased secretion of CCL2 protein CTD PMID:19158351 NCBI chr17:34,255,285...34,257,203
Ensembl chr17:34,255,218...34,257,203
JBrowse link
topiramate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 multiple interactions
increases expression
ISO Amino Acids, Peptides, and Proteins inhibits the reaction [topiramate results in increased expression of ABCB1 protein] CTD PMID:18473823 NCBI chr 7:87,503,017...87,713,295
Ensembl chr 7:87,503,017...87,713,323
JBrowse link
G ABCC1 ATP binding cassette subfamily C member 1 increases expression ISO topiramate results in increased expression of ABCC1 protein CTD PMID:18473823 NCBI chr16:15,949,616...16,143,062
Ensembl chr16:15,949,138...16,143,257
JBrowse link
G ABCC2 ATP binding cassette subfamily C member 2 increases expression ISO topiramate results in increased expression of ABCC2 protein CTD PMID:18473823 NCBI chr10:99,782,602...99,853,741
Ensembl chr10:99,782,640...99,852,594
JBrowse link
G ACADSB acyl-CoA dehydrogenase short/branched chain increases expression ISO topiramate results in increased expression of ACADSB mRNA CTD PMID:16979414 NCBI chr10:123,009,006...123,058,290
Ensembl chr10:123,008,979...123,058,290
JBrowse link
G ACSL4 acyl-CoA synthetase long chain family member 4 decreases expression ISO topiramate results in decreased expression of ACSL4 mRNA CTD PMID:16979414 NCBI chr  X:109,641,335...109,733,325
Ensembl chr  X:109,624,244...109,733,403
JBrowse link
G ADIPOQ adiponectin, C1Q and collagen domain containing increases expression
increases secretion
ISO topiramate results in increased expression of ADIPOQ mRNA
topiramate results in increased secretion of ADIPOQ protein
CTD PMID:12927809 NCBI chr 3:186,842,710...186,858,463
Ensembl chr 3:186,842,704...186,858,463
JBrowse link
G ADRA2A adrenoceptor alpha 2A increases expression ISO topiramate results in increased expression of ADRA2A mRNA CTD PMID:22489711 NCBI chr10:111,077,029...111,080,907
Ensembl chr10:111,077,029...111,080,907
JBrowse link
G AGXT alanine--glyoxylate and serine--pyruvate aminotransferase increases expression ISO topiramate results in increased expression of AGXT mRNA CTD PMID:16979414 NCBI chr 2:240,868,824...240,880,500
Ensembl chr 2:240,868,824...240,880,502
JBrowse link
G AKT1 AKT serine/threonine kinase 1 multiple interactions ISO topiramate inhibits the reaction [3-nitropropionic acid results in decreased phosphorylation of AKT1 protein] CTD PMID:29753867 NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,751
JBrowse link
G ASS1 argininosuccinate synthase 1 decreases expression ISO topiramate results in decreased expression of ASS1 mRNA CTD PMID:16979414 NCBI chr 9:130,444,707...130,501,274
Ensembl chr 9:130,444,961...130,501,274
JBrowse link
G AVPR1A arginine vasopressin receptor 1A decreases expression ISO topiramate results in decreased expression of AVPR1A mRNA CTD PMID:16979414 NCBI chr12:63,142,759...63,151,201
Ensembl chr12:63,142,759...63,151,201
JBrowse link
G BDNF brain derived neurotrophic factor multiple interactions ISO topiramate inhibits the reaction [3-nitropropionic acid results in decreased expression of BDNF protein] CTD PMID:29753867 NCBI chr11:27,654,893...27,722,030
Ensembl chr11:27,654,893...27,722,058
JBrowse link
G CA1 carbonic anhydrase 1 multiple interactions EXP topiramate binds to and results in decreased activity of CA1 protein CTD PMID:17826101 NCBI chr 8:85,327,608...85,378,113
Ensembl chr 8:85,327,608...85,379,014
JBrowse link
G CA12 carbonic anhydrase 12 decreases activity EXP topiramate results in decreased activity of CA12 protein CTD PMID:21314129 NCBI chr15:63,321,378...63,381,846
Ensembl chr15:63,321,378...63,381,846
JBrowse link
G CA2 carbonic anhydrase 2 multiple interactions
decreases activity
EXP topiramate binds to and results in decreased activity of CA2 protein
topiramate results in decreased activity of CA2 protein
CTD PMID:17826101 PMID:21314129 NCBI chr 8:85,464,007...85,481,493
Ensembl chr 8:85,463,968...85,481,493
JBrowse link
G CA3 carbonic anhydrase 3 multiple interactions EXP topiramate binds to and results in decreased activity of CA3 protein CTD PMID:17826101 NCBI chr 8:85,438,859...85,449,040
Ensembl chr 8:85,373,436...85,449,040
JBrowse link
G CALCA calcitonin related polypeptide alpha multiple interactions ISO topiramate inhibits the reaction [Potassium Chloride results in increased secretion of CALCA protein]; topiramate inhibits the reaction [Protons results in increased secretion of CALCA protein]; topiramate inhibits the reaction [S-nitro-N-acetylpenicillamine results in increased secretion of CALCA protein] CTD PMID:16942474 NCBI chr11:14,966,668...14,972,361
Ensembl chr11:14,966,668...14,972,351
JBrowse link
G CAPN6 calpain 6 increases expression ISO topiramate results in increased expression of CAPN6 mRNA CTD PMID:16979414 NCBI chr  X:111,245,099...111,270,483
Ensembl chr  X:111,245,099...111,270,483
JBrowse link
G CASP3 caspase 3 affects expression
multiple interactions
ISO topiramate affects the expression of CASP3 mRNA; topiramate affects the expression of CASP3 protein
topiramate inhibits the reaction [3-nitropropionic acid results in increased activity of CASP3 protein]
CTD PMID:19148780 PMID:29753867 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,649,509
JBrowse link
G CEBPA CCAAT enhancer binding protein alpha decreases expression ISO topiramate results in decreased expression of CEBPA mRNA CTD PMID:16979414 NCBI chr19:33,299,934...33,302,564
Ensembl chr19:33,299,934...33,302,534
JBrowse link
G CHKA choline kinase alpha decreases expression ISO topiramate results in decreased expression of CHKA mRNA CTD PMID:16979414 NCBI chr11:68,052,859...68,121,389
Ensembl chr11:68,052,859...68,121,444
JBrowse link
G CHRNA7 cholinergic receptor nicotinic alpha 7 subunit decreases expression ISO topiramate results in decreased expression of CHRNA7 mRNA CTD PMID:16979414 NCBI chr15:32,030,462...32,173,018
Ensembl chr15:31,923,438...32,173,018
JBrowse link
G CITED2 Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2 decreases expression ISO topiramate results in decreased expression of CITED2 mRNA CTD PMID:16979414 NCBI chr 6:139,371,807...139,374,648
Ensembl chr 6:139,371,807...139,374,648
JBrowse link
G CNR1 cannabinoid receptor 1 affects expression ISO topiramate affects the expression of CNR1 mRNA CTD PMID:22017514 NCBI chr 6:88,139,864...88,167,349
Ensembl chr 6:88,139,864...88,166,347
JBrowse link
G CREB1 cAMP responsive element binding protein 1 multiple interactions ISO topiramate inhibits the reaction [3-nitropropionic acid results in decreased phosphorylation of CREB1 protein] CTD PMID:29753867 NCBI chr 2:207,529,943...207,605,988
Ensembl chr 2:207,529,737...207,605,988
JBrowse link
G CYP17A1 cytochrome P450 family 17 subfamily A member 1 decreases activity EXP topiramate results in decreased activity of CYP17A1 protein CTD PMID:15730543 NCBI chr10:102,830,531...102,837,413
Ensembl chr10:102,830,531...102,837,472
JBrowse link
G CYP3A4 cytochrome P450 family 3 subfamily A member 4 increases activity
increases expression
EXP topiramate results in increased activity of CYP3A4 protein
topiramate results in increased expression of CYP3A4 mRNA; topiramate results in increased expression of CYP3A4 protein
CTD PMID:14636322 NCBI chr 7:99,756,967...99,784,184
Ensembl chr 7:99,756,960...99,784,248
JBrowse link
G DRD2 dopamine receptor D2 increases expression ISO topiramate results in increased expression of DRD2 mRNA CTD PMID:22489711 NCBI chr11:113,409,605...113,475,398
Ensembl chr11:113,409,605...113,475,691
JBrowse link
G DUSP1 dual specificity phosphatase 1 increases expression ISO topiramate results in increased expression of DUSP1 mRNA CTD PMID:16979414 NCBI chr 5:172,768,096...172,771,195
Ensembl chr 5:172,768,096...172,771,195
JBrowse link
G FABP3 fatty acid binding protein 3 decreases expression ISO topiramate results in decreased expression of FABP3 mRNA CTD PMID:16979414 NCBI chr 1:31,359,595...31,373,618
Ensembl chr 1:31,365,253...31,376,850
JBrowse link
G GABRA1 gamma-aminobutyric acid type A receptor subunit alpha1 multiple interactions ISO topiramate inhibits the reaction [[gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein co-treated with GABRB2 protein co-treated with GABRG2 protein]] which results in increased transport of Chlorides] CTD PMID:11123204 NCBI chr 5:161,847,191...161,899,971
Ensembl chr 5:161,847,063...161,899,981
JBrowse link
G GABRA2 gamma-aminobutyric acid type A receptor subunit alpha2 multiple interactions ISO topiramate inhibits the reaction [[gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein co-treated with GABRB2 protein co-treated with GABRG2 protein]] which results in increased transport of Chlorides] CTD PMID:11123204 NCBI chr 4:46,243,548...46,390,300
Ensembl chr 4:46,243,548...46,475,230
JBrowse link
G GABRA6 gamma-aminobutyric acid type A receptor subunit alpha6 multiple interactions ISO topiramate promotes the reaction [[gamma-Aminobutyric Acid results in increased activity of [GABRA6 protein co-treated with GABRB2 protein co-treated with GABRG2 protein]] which results in increased transport of Chlorides] CTD PMID:11123204 NCBI chr 5:161,685,721...161,702,592
Ensembl chr 5:161,547,063...161,702,593
JBrowse link
G GABRB2 gamma-aminobutyric acid type A receptor subunit beta2 multiple interactions ISO topiramate inhibits the reaction [[gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein co-treated with GABRB2 protein co-treated with GABRG2 protein]] which results in increased transport of Chlorides]; topiramate inhibits the reaction [[gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein co-treated with GABRB2 protein co-treated with GABRG2 protein]] which results in increased transport of Chlorides]; topiramate promotes the reaction [[gamma-Aminobutyric Acid results in increased activity of [GABRA6 protein co-treated with GABRB2 protein co-treated with GABRG2 protein]] which results in increased transport of Chlorides] CTD PMID:11123204 NCBI chr 5:161,288,436...161,548,404
Ensembl chr 5:161,288,429...161,549,044
JBrowse link
G GABRG2 gamma-aminobutyric acid type A receptor subunit gamma2 multiple interactions ISO topiramate inhibits the reaction [[gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein co-treated with GABRB2 protein co-treated with GABRG2 protein]] which results in increased transport of Chlorides]; topiramate inhibits the reaction [[gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein co-treated with GABRB2 protein co-treated with GABRG2 protein]] which results in increased transport of Chlorides]; topiramate promotes the reaction [[gamma-Aminobutyric Acid results in increased activity of [GABRA6 protein co-treated with GABRB2 protein co-treated with GABRG2 protein]] which results in increased transport of Chlorides] CTD PMID:11123204 NCBI chr 5:162,067,465...162,155,539
Ensembl chr 5:162,000,057...162,162,977
JBrowse link
G GLUL glutamate-ammonia ligase decreases activity ISO topiramate results in decreased activity of GLUL protein CTD PMID:10323596 NCBI chr 1:182,378,098...182,391,790
Ensembl chr 1:182,378,098...182,392,206
JBrowse link
G GNAI2 G protein subunit alpha i2 decreases expression ISO topiramate results in decreased expression of GNAI2 mRNA CTD PMID:16979414 NCBI chr 3:50,227,068...50,259,362
Ensembl chr 3:50,226,292...50,259,362
JBrowse link
G GOT2 glutamic-oxaloacetic transaminase 2 increases expression ISO topiramate results in increased expression of GOT2 mRNA CTD PMID:16979414 NCBI chr16:58,707,131...58,734,316
Ensembl chr16:58,707,131...58,734,342
JBrowse link
G GPAM glycerol-3-phosphate acyltransferase, mitochondrial decreases expression ISO topiramate results in decreased expression of GPAM mRNA CTD PMID:16979414 NCBI chr10:112,149,865...112,216,306
Ensembl chr10:112,149,865...112,215,377
JBrowse link
G GPD2 glycerol-3-phosphate dehydrogenase 2 increases expression ISO topiramate results in increased expression of GPD2 mRNA CTD PMID:16979414 NCBI chr 2:156,435,290...156,586,403
Ensembl chr 2:156,435,290...156,613,735
JBrowse link
G GRIA2 glutamate ionotropic receptor AMPA type subunit 2 multiple interactions ISO topiramate inhibits the reaction [3-nitropropionic acid results in decreased expression of GRIA2 mRNA] CTD PMID:29753867 NCBI chr 4:157,220,120...157,370,583
Ensembl chr 4:157,204,182...157,366,075
JBrowse link
G GRIK1 glutamate ionotropic receptor kainate type subunit 1 affects response to substance EXP GRIK1 gene SNP affects the susceptibility to topiramate CTD PMID:19331489 NCBI chr21:29,536,933...29,939,996
Ensembl chr21:29,536,933...29,940,033
JBrowse link
G GSK3B glycogen synthase kinase 3 beta multiple interactions ISO topiramate inhibits the reaction [3-nitropropionic acid results in decreased phosphorylation of GSK3B protein] CTD PMID:29753867 NCBI chr 3:119,821,321...120,095,823
Ensembl chr 3:119,821,321...120,094,994
JBrowse link
G GTF2A2 general transcription factor IIA subunit 2 increases expression ISO topiramate results in increased expression of GTF2A2 mRNA CTD PMID:16979414 NCBI chr15:59,638,062...59,657,515
Ensembl chr15:59,638,062...59,657,541
JBrowse link
G GYG1 glycogenin 1 decreases expression ISO topiramate results in decreased expression of GYG1 mRNA CTD PMID:16979414 NCBI chr 3:148,991,515...149,031,775
Ensembl chr 3:148,991,408...149,031,775
JBrowse link
G HLA-A major histocompatibility complex, class I, A affects expression EXP topiramate affects the expression of HLA-A mRNA CTD PMID:25811541 NCBI chr 6:29,942,532...29,945,870
Ensembl chr 6:29,941,260...29,945,884
JBrowse link
G HLA-DMB major histocompatibility complex, class II, DM beta affects expression EXP topiramate affects the expression of HLA-DMB mRNA CTD PMID:25811541 NCBI chr 6:32,934,636...32,941,028
Ensembl chr 6:32,934,629...32,941,028
JBrowse link
G HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 increases expression ISO topiramate results in increased expression of HMGCS1 mRNA CTD PMID:16979414 NCBI chr 5:43,287,470...43,313,477
Ensembl chr 5:43,287,470...43,313,512
JBrowse link
G HSD3B2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 decreases activity EXP topiramate results in decreased activity of HSD3B2 protein CTD PMID:15730543 NCBI chr 1:119,414,931...119,423,034
Ensembl chr 1:119,414,931...119,423,035
JBrowse link
G IDI1 isopentenyl-diphosphate delta isomerase 1 increases expression ISO topiramate results in increased expression of IDI1 mRNA CTD PMID:16979414 NCBI chr10:1,039,152...1,056,704
Ensembl chr10:1,039,152...1,049,119
JBrowse link
G IFI30 IFI30 lysosomal thiol reductase multiple interactions ISO [topiramate co-treated with Trinitrobenzenesulfonic Acid] results in decreased expression of IFI30 mRNA CTD PMID:21849664 NCBI chr19:18,173,813...18,178,117
Ensembl chr19:18,173,162...18,178,117
JBrowse link
G IGF1 insulin like growth factor 1 decreases expression ISO topiramate results in decreased expression of IGF1 mRNA CTD PMID:16979414 NCBI chr12:102,395,860...102,481,839
Ensembl chr12:102,395,874...102,481,744
JBrowse link
G ITPR1 inositol 1,4,5-trisphosphate receptor type 1 increases expression ISO topiramate results in increased expression of ITPR1 mRNA CTD PMID:16979414 NCBI chr 3:4,493,348...4,847,506
Ensembl chr 3:4,493,345...4,847,506
JBrowse link
G KCNH2 potassium voltage-gated channel subfamily H member 2 decreases activity EXP topiramate results in decreased activity of KCNH2 protein CTD PMID:15716081 NCBI chr 7:150,944,956...150,978,321
Ensembl chr 7:150,944,961...150,978,321
JBrowse link
G ME1 malic enzyme 1 decreases expression ISO topiramate results in decreased expression of ME1 mRNA CTD PMID:16979414 NCBI chr 6:83,210,402...83,431,078
Ensembl chr 6:83,210,402...83,431,051
JBrowse link
G MVD mevalonate diphosphate decarboxylase increases expression ISO topiramate results in increased expression of MVD mRNA CTD PMID:16979414 NCBI chr16:88,651,935...88,663,153
Ensembl chr16:88,651,935...88,663,161
JBrowse link
G NOS2 nitric oxide synthase 2 increases expression ISO topiramate results in increased expression of NOS2 protein CTD PMID:14511393 NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529
JBrowse link
G NPY neuropeptide Y increases expression ISO topiramate results in increased expression of NPY protein CTD PMID:17572454 NCBI chr 7:24,284,190...24,291,862
Ensembl chr 7:24,284,188...24,291,862
JBrowse link
G NR1I2 nuclear receptor subfamily 1 group I member 2 increases activity EXP topiramate results in increased activity of NR1I2 protein CTD PMID:14636322 NCBI chr 3:119,782,101...119,818,487
Ensembl chr 3:119,780,484...119,818,487
JBrowse link
G NR2F2 nuclear receptor subfamily 2 group F member 2 decreases expression ISO topiramate results in decreased expression of NR2F2 mRNA CTD PMID:16979414 NCBI chr15:96,326,046...96,340,263
Ensembl chr15:96,325,938...96,340,263
JBrowse link
G NR4A2 nuclear receptor subfamily 4 group A member 2 decreases expression ISO topiramate results in decreased expression of NR4A2 mRNA CTD PMID:16979414 NCBI chr 2:156,324,432...156,332,724
Ensembl chr 2:156,324,437...156,342,348
JBrowse link
G PDE4B phosphodiesterase 4B decreases expression ISO topiramate results in decreased expression of PDE4B mRNA CTD PMID:16979414 NCBI chr 1:65,792,510...66,374,579
Ensembl chr 1:65,792,514...66,374,579
JBrowse link
G PDK4 pyruvate dehydrogenase kinase 4 decreases expression ISO topiramate results in decreased expression of PDK4 mRNA CTD PMID:16979414 NCBI chr 7:95,583,499...95,596,516
Ensembl chr 7:95,583,499...95,596,516
JBrowse link
G PICK1 protein interacting with PRKCA 1 multiple interactions ISO topiramate inhibits the reaction [3-nitropropionic acid results in increased expression of PICK1 protein] CTD PMID:29753867 NCBI chr22:38,056,311...38,075,704
Ensembl chr22:38,056,311...38,075,701
JBrowse link
G PLCD4 phospholipase C delta 4 decreases expression ISO topiramate results in decreased expression of PLCD4 mRNA CTD PMID:16979414 NCBI chr 2:218,606,871...218,637,186
Ensembl chr 2:218,607,855...218,637,184
JBrowse link
G PLD1 phospholipase D1 increases expression ISO topiramate results in increased expression of PLD1 mRNA CTD PMID:16979414 NCBI chr 3:171,600,404...171,810,483
Ensembl chr 3:171,600,404...171,810,950
JBrowse link
G PPP5C protein phosphatase 5 catalytic subunit increases expression ISO topiramate results in increased expression of PPP5C mRNA CTD PMID:16979414 NCBI chr19:46,347,069...46,390,975
Ensembl chr19:46,347,087...46,392,981
JBrowse link
G PRKAG1 protein kinase AMP-activated non-catalytic subunit gamma 1 decreases expression ISO topiramate results in decreased expression of PRKAG1 mRNA CTD PMID:16979414 NCBI chr12:49,002,272...49,018,975
Ensembl chr12:49,002,274...49,018,807
JBrowse link
G PRKAR2B protein kinase cAMP-dependent type II regulatory subunit beta decreases expression ISO topiramate results in decreased expression of PRKAR2B mRNA CTD PMID:16979414 NCBI chr 7:107,044,705...107,161,811
Ensembl chr 7:107,044,705...107,161,811
JBrowse link
G SCD stearoyl-CoA desaturase decreases expression ISO topiramate results in decreased expression of SCD1 mRNA CTD PMID:16979414 NCBI chr10:100,347,233...100,364,826
Ensembl chr10:100,347,233...100,364,826
JBrowse link
G SLC16A1 solute carrier family 16 member 1 increases expression ISO topiramate results in increased expression of SLC16A1 mRNA CTD PMID:16979414 NCBI chr 1:112,911,847...112,956,196
Ensembl chr 1:112,911,847...112,957,593
JBrowse link
G SLC37A4 solute carrier family 37 member 4 decreases expression ISO topiramate results in decreased expression of SLC37A4 mRNA CTD PMID:16979414 NCBI chr11:119,024,112...119,030,877
Ensembl chr11:119,024,114...119,030,906
JBrowse link
G SLC47A1 solute carrier family 47 member 1 multiple interactions EXP topiramate affects the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr17:19,533,854...19,579,034
Ensembl chr17:19,495,385...19,579,034
JBrowse link
G SLC6A6 solute carrier family 6 member 6 decreases expression ISO topiramate results in decreased expression of SLC6A6 mRNA CTD PMID:16979414 NCBI chr 3:14,402,576...14,489,349
Ensembl chr 3:14,402,576...14,489,349
JBrowse link
G SLC7A1 solute carrier family 7 member 1 decreases expression ISO topiramate results in decreased expression of SLC7A1 mRNA CTD PMID:16979414 NCBI chr13:29,509,410...29,595,688
Ensembl chr13:29,509,414...29,595,688
JBrowse link
G SQLE squalene epoxidase decreases expression ISO topiramate results in decreased expression of SQLE mRNA CTD PMID:16979414 NCBI chr 8:124,998,505...125,022,283
Ensembl chr 8:124,998,497...125,022,283
JBrowse link
G SREBF1 sterol regulatory element binding transcription factor 1 increases expression ISO topiramate results in increased expression of SREBF1 mRNA CTD PMID:16979414 NCBI chr17:17,811,334...17,837,017
Ensembl chr17:17,810,399...17,837,002
JBrowse link
G TH tyrosine hydroxylase affects expression
increases expression
ISO topiramate affects the expression of TH mRNA
topiramate results in increased expression of TH mRNA
CTD PMID:22017514 PMID:22489711 NCBI chr11:2,163,929...2,174,081
Ensembl chr11:2,163,929...2,171,815
JBrowse link
G TRPV1 transient receptor potential cation channel subfamily V member 1 multiple interactions ISO topiramate inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of TRPV1 mRNA] CTD PMID:21849664 NCBI chr17:3,565,446...3,609,411
Ensembl chr17:3,565,444...3,609,411
JBrowse link
G UCP3 uncoupling protein 3 decreases expression ISO topiramate results in decreased expression of UCP3 mRNA CTD PMID:16979414 NCBI chr11:74,000,277...74,009,085
Ensembl chr11:74,000,277...74,009,085
JBrowse link
G UGT2B7 UDP glucuronosyltransferase family 2 member B7 affects response to substance EXP UGT2B7 gene SNP affects the susceptibility to topiramate CTD PMID:18686368 NCBI chr 4:69,051,375...69,112,987
Ensembl chr 4:69,051,363...69,112,987
JBrowse link
xylulose term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DCXR dicarbonyl and L-xylulose reductase multiple interactions
increases metabolic processing
EXP [DCXR protein co-treated with NAD] results in increased reduction of Xylulose; [DCXR protein co-treated with NADP] results in increased reduction of Xylulose; [DCXR protein results in increased metabolism of Xylulose] which results in increased chemical synthesis of Xylitol CTD PMID:28595002 NCBI chr17:82,035,858...82,037,697
Ensembl chr17:82,035,136...82,037,709
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 24830
    chemical entity 24800
      atom 24789
        nonmetal atom 24526
          oxygen atom 23684
            oxygen molecular entity 23684
              organooxygen compound 23224
                carbohydrates and carbohydrate derivatives 13164
                  carbohydrate 13164
                    monosaccharide 4442
                      ketose 409
                        ketoheptose + 1
                        ketohexose + 373
                        ketooctose + 0
                        ketopentose + 2
                        ketose derivative + 3
                        ketotetrose + 0
                        ketotriose + 54
Path 2
Term Annotations click to browse term
  CHEBI ontology 24830
    subatomic particle 24789
      composite particle 24789
        hadron 24789
          baryon 24789
            nucleon 24789
              atomic nucleus 24789
                atom 24789
                  main group element atom 24656
                    p-block element atom 24656
                      carbon group element atom 24452
                        carbon atom 24416
                          organic molecular entity 24416
                            heteroorganic entity 23813
                              organochalcogen compound 23378
                                organooxygen compound 23224
                                  carbohydrates and carbohydrate derivatives 13164
                                    carbohydrate 13164
                                      monosaccharide 4442
                                        ketose 409
                                          ketoheptose + 1
                                          ketohexose + 373
                                          ketooctose + 0
                                          ketopentose + 2
                                          ketose derivative + 3
                                          ketotetrose + 0
                                          ketotriose + 54
paths to the root