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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:ketose
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Accession:CHEBI:24978 term browser browse the term
Definition:Ketonic parent sugars (polyhydroxy ketones H[CH(OH)]nC(=O)[CH(OH)]mH) and their intramolecular hemiketals.
Synonyms:related_synonym: ketoses
 alt_id: CHEBI:6131



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3-deoxyglucosone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1b8 aldo-keto reductase family 1, member B8 multiple interactions EXP [AKR1B8 protein co-treated with NADP] affects the reduction of 3-deoxyglucosone CTD PMID:18845131 NCBI chr 4:62,997,241...63,009,815 JBrowse link
beta-D-fructofuranose 1,6-bisphosphate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gapdh glyceraldehyde-3-phosphate dehydrogenase multiple interactions EXP [GAPDH protein co-treated with fructose-1,6-diphosphate co-treated with NAD] results in increased chemical synthesis of sodium arsenite; [GAPDH protein co-treated with fructose-1,6-diphosphate co-treated with NAD] results in increased reduction of sodium arsenate analog; heptelidic acid inhibits the reaction [[GAPDH protein co-treated with fructose-1,6-diphosphate co-treated with NAD] results in increased reduction of sodium arsenate analog] CTD PMID:15788719 NCBI chr 4:157,962,312...157,967,158
Ensembl chr 4:157,962,343...157,966,235
JBrowse link
G Idh2 isocitrate dehydrogenase (NADP(+)) 2 increases abundance
multiple interactions
ISO IDH2 protein mutant form results in increased abundance of fructose-1,6-diphosphate
Triazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of fructose-1,6-diphosphate]
CTD PMID:27469509 NCBI chr 1:134,038,644...134,057,969
Ensembl chr 1:134,029,772...134,058,025
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO fructose-1,6-diphosphate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein] CTD PMID:22227475 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO fructose-1,6-diphosphate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein] CTD PMID:22227475 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
decreases degradation
ISO fructose-1,6-diphosphate inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; fructose-1,6-diphosphate inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]
fructose-1,6-diphosphate results in decreased degradation of NOS2 mRNA
CTD PMID:22227475 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
beta-D-fructofuranose 2,6-bisphosphate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fbp1 fructose-bisphosphatase 1 decreases activity ISO fructose 2,6-diphosphate results in decreased activity of FBP1 protein CTD PMID:31974165 NCBI chr17:2,207,271...2,230,076
Ensembl chr17:2,208,031...2,230,071
JBrowse link
G Pfkfb1 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 decreases abundance ISO PFKFB1 gene mutant form results in decreased abundance of fructose 2,6-diphosphate CTD PMID:31974165 NCBI chr  X:19,508,522...19,562,165
Ensembl chr  X:19,508,546...19,562,182
JBrowse link
G Pfkm phosphofructokinase, muscle multiple interactions ISO fructose 2,6-diphosphate inhibits the reaction [resveratrol results in decreased activity of PFKM protein] CTD PMID:23454376 NCBI chr 7:129,221,679...129,259,192
Ensembl chr 7:129,221,653...129,259,192
JBrowse link
D-fructofuranose 1,6-bisphosphate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gapdh glyceraldehyde-3-phosphate dehydrogenase multiple interactions EXP [GAPDH protein co-treated with fructose-1,6-diphosphate co-treated with NAD] results in increased chemical synthesis of sodium arsenite; [GAPDH protein co-treated with fructose-1,6-diphosphate co-treated with NAD] results in increased reduction of sodium arsenate analog; heptelidic acid inhibits the reaction [[GAPDH protein co-treated with fructose-1,6-diphosphate co-treated with NAD] results in increased reduction of sodium arsenate analog] CTD PMID:15788719 NCBI chr 4:157,962,312...157,967,158
Ensembl chr 4:157,962,343...157,966,235
JBrowse link
G Idh2 isocitrate dehydrogenase (NADP(+)) 2 increases abundance
multiple interactions
ISO IDH2 protein mutant form results in increased abundance of fructose-1,6-diphosphate
Triazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of fructose-1,6-diphosphate]
CTD PMID:27469509 NCBI chr 1:134,038,644...134,057,969
Ensembl chr 1:134,029,772...134,058,025
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO fructose-1,6-diphosphate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein] CTD PMID:22227475 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO fructose-1,6-diphosphate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein] CTD PMID:22227475 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
decreases degradation
ISO fructose-1,6-diphosphate inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; fructose-1,6-diphosphate inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]
fructose-1,6-diphosphate results in decreased degradation of NOS2 mRNA
CTD PMID:22227475 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
D-xylulose 5-phosphate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Taldo1 transaldolase 1 increases abundance ISO TALDO1 gene mutant form results in increased abundance of xylulose-5-phosphate CTD PMID:19436114 NCBI chr 1:196,493,634...196,503,965
Ensembl chr 1:196,493,589...196,503,974
JBrowse link
dihydroxyacetone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atm ATM serine/threonine kinase decreases expression ISO Dihydroxyacetone results in decreased expression of ATM mRNA CTD PMID:32506039 NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437
JBrowse link
G Casp3 caspase 3 increases cleavage ISO Dihydroxyacetone results in increased cleavage of CASP3 protein CTD PMID:29193605 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Ccl21 C-C motif chemokine ligand 21 decreases expression ISO Dihydroxyacetone results in decreased expression of CCL21 mRNA CTD PMID:32506039 NCBI chr 5:56,980,557...56,981,661
Ensembl chr 5:56,980,558...56,981,686
JBrowse link
G Ccl3 C-C motif chemokine ligand 3 decreases expression ISO Dihydroxyacetone results in decreased expression of CCL3 mRNA CTD PMID:32506039 NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938
JBrowse link
G Ccl4 C-C motif chemokine ligand 4 decreases expression ISO Dihydroxyacetone results in decreased expression of CCL4 mRNA CTD PMID:32506039 NCBI chr10:68,466,469...68,467,941
Ensembl chr10:68,452,052...68,468,231
JBrowse link
G Ccnc cyclin C increases expression ISO Dihydroxyacetone results in increased expression of CCNC mRNA CTD PMID:32506039 NCBI chr 5:35,266,828...35,284,943
Ensembl chr 5:35,266,823...35,296,584
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A decreases expression ISO Dihydroxyacetone results in decreased expression of CDKN1A mRNA CTD PMID:32506039 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Cel carboxyl ester lipase increases expression ISO Dihydroxyacetone results in increased expression of CEL protein CTD PMID:32506039 NCBI chr 3:11,883,532...11,891,035
Ensembl chr 3:11,883,532...11,891,035
JBrowse link
G Chek2 checkpoint kinase 2 decreases expression ISO Dihydroxyacetone results in decreased expression of CHEK2 mRNA CTD PMID:32506039 NCBI chr12:45,788,823...45,821,382
Ensembl chr12:45,788,827...45,821,286
JBrowse link
G Cryab crystallin, alpha B increases expression ISO Dihydroxyacetone results in increased expression of CRYAB mRNA; Dihydroxyacetone results in increased expression of CRYAB protein CTD PMID:32506039 NCBI chr 8:51,093,441...51,099,161
Ensembl chr 8:51,093,441...51,099,157
JBrowse link
G Csf2 colony stimulating factor 2 increases expression ISO Dihydroxyacetone results in increased expression of CSF2 mRNA CTD PMID:32506039 NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases expression ISO Dihydroxyacetone results in decreased expression of CYP1A1 mRNA CTD PMID:32506039 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 decreases expression ISO Dihydroxyacetone results in decreased expression of CYP2E1 mRNA CTD PMID:32506039 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 decreases expression ISO Dihydroxyacetone results in decreased expression of CYP7A1 mRNA CTD PMID:32506039 NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO Dihydroxyacetone results in increased expression of DDIT3 mRNA CTD PMID:32506039 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
JBrowse link
G Dnajb4 DnaJ heat shock protein family (Hsp40) member B4 increases expression ISO Dihydroxyacetone results in increased expression of DNAJB4 mRNA CTD PMID:32506039 NCBI chr 2:241,129,346...241,159,272
Ensembl chr 2:241,130,340...241,159,089
JBrowse link
G E2f1 E2F transcription factor 1 increases expression ISO Dihydroxyacetone results in increased expression of E2F1 mRNA CTD PMID:32506039 NCBI chr 3:143,064,535...143,075,362 JBrowse link
G Egr1 early growth response 1 affects expression ISO Dihydroxyacetone affects the expression of EGR1 mRNA CTD PMID:32506039 NCBI chr18:26,463,333...26,465,531
Ensembl chr18:26,462,981...26,466,766
JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha increases phosphorylation ISO Dihydroxyacetone results in increased phosphorylation of EIF2S1 protein CTD PMID:32506039 NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225
JBrowse link
G Ephx2 epoxide hydrolase 2 decreases expression ISO Dihydroxyacetone results in decreased expression of EPHX2 mRNA CTD PMID:32506039 NCBI chr15:40,289,901...40,327,632
Ensembl chr15:40,289,902...40,327,615
JBrowse link
G Ercc3 ERCC excision repair 3, TFIIH core complex helicase subunit increases expression ISO Dihydroxyacetone results in increased expression of ERCC3 mRNA CTD PMID:32506039 NCBI chr18:23,883,613...23,914,326
Ensembl chr18:23,883,580...23,914,329
JBrowse link
G Faslg Fas ligand affects expression ISO Dihydroxyacetone affects the expression of FASLG mRNA CTD PMID:32506039 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215
JBrowse link
G Fmo1 flavin containing dimethylaniline monoxygenase 1 decreases expression ISO Dihydroxyacetone results in decreased expression of FMO1 mRNA CTD PMID:32506039 NCBI chr13:75,182,184...75,214,439
Ensembl chr13:75,182,176...75,214,647
JBrowse link
G Gdf15 growth differentiation factor 15 decreases expression ISO Dihydroxyacetone results in decreased expression of GDF15 mRNA CTD PMID:32506039 NCBI chr16:18,805,312...18,807,893
Ensembl chr16:18,805,239...18,808,055
JBrowse link
G Glo1 glyoxalase 1 affects response to substance ISO GLO1 protein affects the susceptibility to Dihydroxyacetone CTD PMID:32506039 NCBI chr20:8,663,617...8,681,661
Ensembl chr20:8,662,801...8,681,649
JBrowse link
G Gpd2 glycerol-3-phosphate dehydrogenase 2 multiple interactions ISO GPD2 protein inhibits the reaction [Dihydroxyacetone results in increased abundance of alpha-glycerophosphoric acid]; GPD2 protein inhibits the reaction [Dihydroxyacetone results in increased abundance of Glucose-6-Phosphate] CTD PMID:31974165 NCBI chr 3:41,800,552...41,937,729
Ensembl chr 3:41,801,930...41,936,901
JBrowse link
G H2ax H2A.X variant histone increases expression ISO Dihydroxyacetone results in increased expression of H2AX protein CTD PMID:32506039 NCBI chr 8:44,671,927...44,673,257
Ensembl chr 8:44,671,786...44,673,239
JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO Dihydroxyacetone results in increased expression of HMOX1 mRNA; Dihydroxyacetone results in increased expression of HMOX1 protein CTD PMID:32506039 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A increases expression ISO Dihydroxyacetone results in increased expression of HSPA1A mRNA CTD PMID:32506039
G Hspa2 heat shock protein family A (Hsp70) member 2 increases expression ISO Dihydroxyacetone results in increased expression of HSPA2 mRNA CTD PMID:32506039 NCBI chr 6:95,128,504...95,131,281
Ensembl chr 6:95,128,350...95,131,287
JBrowse link
G Hspb1 heat shock protein family B (small) member 1 increases phosphorylation ISO Dihydroxyacetone results in increased phosphorylation of HSPB1 protein CTD PMID:32506039 NCBI chr12:20,794,014...20,795,675
Ensembl chr12:20,794,028...20,795,743
JBrowse link
G Hspd1 heat shock protein family D (Hsp60) member 1 increases expression ISO Dihydroxyacetone results in increased expression of HSPD1 mRNA CTD PMID:32506039 NCBI chr 9:56,579,195...56,590,011
Ensembl chr 9:56,579,201...56,589,662
JBrowse link
G Hspe1 heat shock protein family E (Hsp10) member 1 increases expression ISO Dihydroxyacetone results in increased expression of HSPE1 mRNA CTD PMID:32506039 NCBI chr 9:56,589,912...56,593,000
Ensembl chr 9:56,589,789...56,593,089
JBrowse link
G Il6 interleukin 6 increases expression ISO Dihydroxyacetone results in increased expression of IL6 mRNA CTD PMID:32506039 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G LOC686035 similar to heat shock 70kDa protein 6 (HSP70B) increases expression ISO Dihydroxyacetone results in increased expression of HSPA6 protein CTD PMID:32506039 NCBI chr13:83,271,340...83,275,267 JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation ISO Dihydroxyacetone results in increased phosphorylation of MAPK1 protein CTD PMID:32506039 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation ISO Dihydroxyacetone results in increased phosphorylation of MAPK3 protein CTD PMID:32506039 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mmp10 matrix metallopeptidase 10 decreases secretion ISO Dihydroxyacetone results in decreased secretion of MMP10 protein CTD PMID:30959092 NCBI chr 8:4,689,840...4,697,748
Ensembl chr 8:4,689,840...4,697,748
JBrowse link
G Mmp13 matrix metallopeptidase 13 decreases secretion ISO Dihydroxyacetone results in decreased secretion of MMP13 protein CTD PMID:30959092 NCBI chr 8:4,497,960...4,508,239
Ensembl chr 8:4,497,960...4,508,239
JBrowse link
G Mt2A metallothionein 2A decreases expression ISO Dihydroxyacetone results in decreased expression of MT2A mRNA CTD PMID:32506039 NCBI chr19:10,832,009...10,832,783
Ensembl chr19:10,832,002...10,832,784
JBrowse link
G Muc5ac mucin 5AC, oligomeric mucus/gel-forming decreases secretion ISO Dihydroxyacetone results in decreased secretion of MUC5AC protein CTD PMID:30959092 NCBI chr 1:196,864,375...196,896,475 JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 increases expression ISO Dihydroxyacetone results in increased expression of NFE2L2 protein CTD PMID:32506039 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 decreases expression ISO Dihydroxyacetone results in decreased expression of NFKB1 mRNA CTD PMID:32506039 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
JBrowse link
G Nos2 nitric oxide synthase 2 decreases expression ISO Dihydroxyacetone results in decreased expression of NOS2 mRNA CTD PMID:32506039 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Oat ornithine aminotransferase multiple interactions EXP Dihydroxyacetone inhibits the reaction [Cyclic AMP results in increased activity of OAT protein] CTD PMID:2827574 NCBI chr 1:187,347,862...187,367,644
Ensembl chr 1:187,347,865...187,367,682
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO Dihydroxyacetone results in increased cleavage of PARP1 protein CTD PMID:29193605 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Pcna proliferating cell nuclear antigen increases expression ISO Dihydroxyacetone results in increased expression of PCNA mRNA CTD PMID:32506039 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
JBrowse link
G Pklr pyruvate kinase L/R multiple interactions EXP 4-hydroxy-3-(4-(2-hydroxyphenyl)phenyl)-6-oxo-7H-thieno(2,3-b)pyridine-5-carbonitrile inhibits the reaction [Dihydroxyacetone results in increased expression of PKLR mRNA] CTD PMID:31974165 NCBI chr 2:174,543,008...174,551,863
Ensembl chr 2:174,543,039...174,551,870
JBrowse link
G Prkaa1 protein kinase AMP-activated catalytic subunit alpha 1 multiple interactions ISO [[PRKAA1 gene mutant form co-treated with PRKAA2 gene mutant form] affects the susceptibility to [Dihydroxyacetone co-treated with S 4048]] which results in decreased abundance of Adenosine Triphosphate; [PRKAA1 gene mutant form co-treated with PRKAA2 gene mutant form] affects the susceptibility to [Dihydroxyacetone co-treated with S 4048] CTD PMID:31974165 NCBI chr 2:54,240,298...54,275,978
Ensembl chr 2:54,240,137...54,275,978
JBrowse link
G Prkaa2 protein kinase AMP-activated catalytic subunit alpha 2 multiple interactions ISO [[PRKAA1 gene mutant form co-treated with PRKAA2 gene mutant form] affects the susceptibility to [Dihydroxyacetone co-treated with S 4048]] which results in decreased abundance of Adenosine Triphosphate; [PRKAA1 gene mutant form co-treated with PRKAA2 gene mutant form] affects the susceptibility to [Dihydroxyacetone co-treated with S 4048] CTD PMID:31974165 NCBI chr 5:119,807,992...119,879,987
Ensembl chr 5:119,813,226...119,879,543
JBrowse link
G Tnf tumor necrosis factor increases expression ISO Dihydroxyacetone results in increased expression of TNF mRNA CTD PMID:32506039 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A affects expression ISO Dihydroxyacetone affects the expression of TNFRSF1A mRNA CTD PMID:32506039 NCBI chr 4:158,150,815...158,163,592
Ensembl chr 4:158,150,820...158,163,591
JBrowse link
G Tnfsf10 TNF superfamily member 10 decreases expression ISO Dihydroxyacetone results in decreased expression of TNFSF10 mRNA CTD PMID:32506039 NCBI chr 2:110,199,835...110,227,239
Ensembl chr 2:110,207,916...110,225,135
JBrowse link
G Ung uracil-DNA glycosylase decreases expression ISO Dihydroxyacetone results in decreased expression of UNG mRNA CTD PMID:32506039 NCBI chr12:42,485,276...42,494,217
Ensembl chr12:42,485,276...42,494,206
JBrowse link
G Xrcc2 X-ray repair cross complementing 2 increases expression ISO Dihydroxyacetone results in increased expression of XRCC2 mRNA; Dihydroxyacetone results in increased expression of XRCC2 protein CTD PMID:32506039 NCBI chr 4:9,423,873...9,502,980
Ensembl chr 4:9,423,898...9,442,482
JBrowse link
dihydroxyacetone phosphate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Idh2 isocitrate dehydrogenase (NADP(+)) 2 increases abundance
multiple interactions
ISO IDH2 protein mutant form results in increased abundance of Dihydroxyacetone Phosphate
Triazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of Dihydroxyacetone Phosphate]
CTD PMID:27469509 NCBI chr 1:134,038,644...134,057,969
Ensembl chr 1:134,029,772...134,058,025
JBrowse link
G Tpi1 triosephosphate isomerase 1 affects metabolic processing EXP TPI1 protein affects the metabolism of Dihydroxyacetone Phosphate CTD PMID:14762718 NCBI chr 4:157,615,283...157,618,813
Ensembl chr 4:157,615,386...157,619,541
JBrowse link
fructose term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A1bg alpha-1-B glycoprotein multiple interactions EXP [Fructose co-treated with bisphenol A] results in decreased expression of A1BG protein CTD PMID:26930160 NCBI chr 7:92,493,934...92,498,460
Ensembl chr 7:92,494,372...92,498,097
JBrowse link
G Abca1 ATP binding cassette subfamily A member 1 multiple interactions
increases expression
EXP Tea inhibits the reaction [Fructose results in increased expression of ABCA1 mRNA] CTD PMID:19193814 NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 multiple interactions
decreases expression
EXP Ascorbic Acid inhibits the reaction [Fructose results in decreased expression of ABCC2 mRNA]; Ascorbic Acid inhibits the reaction [Fructose results in decreased expression of ABCC2 protein]; geraniol inhibits the reaction [Fructose results in decreased expression of ABCC2 mRNA]; geraniol inhibits the reaction [Fructose results in decreased expression of ABCC2 protein]
Fructose results in decreased expression of ABCC2 mRNA; Fructose results in decreased expression of ABCC2 protein
CTD PMID:31005848 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
JBrowse link
G Acaca acetyl-CoA carboxylase alpha multiple interactions
decreases phosphorylation
increases expression
ISO
EXP
FGF21 gene mutant form inhibits the reaction [Fructose results in increased expression of ACACA mRNA]; Phenylbutyrates inhibits the reaction [Fructose results in increased expression of ACACA mRNA]; SCD1 gene mutant form inhibits the reaction [Fructose results in increased expression of ACACA mRNA]; Triolein inhibits the reaction [SCD1 gene mutant form inhibits the reaction [Fructose results in increased expression of ACACA mRNA]]; Triolein promotes the reaction [Fructose results in increased expression of ACACA mRNA]
[Fructose co-treated with Palmitic Acid] results in decreased expression of ACACA protein modified form; [Fructose co-treated with Palmitic Acid] results in increased expression of ACACA protein; Fenofibrate inhibits the reaction [[Fructose co-treated with Palmitic Acid] results in decreased expression of ACACA protein modified form]; Fenofibrate inhibits the reaction [[Fructose co-treated with Palmitic Acid] results in increased expression of ACACA protein]
Fructose results in decreased phosphorylation of ACACA protein
[6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in decreased activity of SIRT1 protein] inhibits the reaction [Fructose results in increased expression of ACACA mRNA]; [Niacinamide results in decreased activity of SIRT1 protein] inhibits the reaction [Fructose results in increased expression of ACACA mRNA]; Fructose inhibits the reaction [Streptozocin results in decreased activity of ACACA protein]; Fructose inhibits the reaction [Streptozocin results in decreased expression of ACACA mRNA]; Rotenone inhibits the reaction [Fructose results in increased expression of ACACA mRNA]
CTD PMID:1973097 PMID:15066988 PMID:21212096 PMID:22698815 PMID:28123933 More... NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457
JBrowse link
G Acacb acetyl-CoA carboxylase beta decreases expression
increases expression
multiple interactions
ISO
EXP
Fructose results in decreased expression of ACACB mRNA
Fructose results in increased expression of ACACB mRNA
FGF21 gene mutant form inhibits the reaction [Fructose results in increased expression of ACACB mRNA]
CTD PMID:18063403 PMID:19053045 PMID:28123933 NCBI chr12:42,365,800...42,477,651
Ensembl chr12:42,366,548...42,457,655
JBrowse link
G Acadl acyl-CoA dehydrogenase, long chain multiple interactions EXP [Fructose co-treated with Copper deficiency] results in decreased expression of ACADL mRNA CTD PMID:25813056 NCBI chr 9:68,333,981...68,372,149
Ensembl chr 9:68,333,980...68,372,220
JBrowse link
G Acadm acyl-CoA dehydrogenase medium chain multiple interactions EXP [Fructose co-treated with Copper deficiency] results in decreased expression of ACADM mRNA CTD PMID:25813056 NCBI chr 2:242,858,865...242,883,036
Ensembl chr 2:242,858,865...242,883,147
JBrowse link
G Acads acyl-CoA dehydrogenase short chain multiple interactions EXP [Fructose co-treated with bisphenol A] results in decreased expression of ACADS protein CTD PMID:26930160 NCBI chr12:41,493,650...41,502,897
Ensembl chr12:41,493,626...41,502,898
JBrowse link
G Acadvl acyl-CoA dehydrogenase, very long chain multiple interactions EXP [Fructose co-treated with bisphenol A] results in increased expression of ACADVL protein; [Fructose co-treated with Copper deficiency] results in decreased expression of ACADVL mRNA CTD PMID:25813056 PMID:26930160 NCBI chr10:54,732,875...54,738,102
Ensembl chr10:54,732,469...54,738,075
JBrowse link
G Ace angiotensin I converting enzyme increases expression
multiple interactions
EXP Fructose results in increased expression of ACE mRNA
[bisphenol A co-treated with Fructose] results in increased expression of ACE mRNA; APLN protein modified form inhibits the reaction [Fructose results in increased expression of ACE mRNA]
CTD PMID:17587757 PMID:27622962 PMID:30710622 NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131
JBrowse link
G Ache acetylcholinesterase multiple interactions EXP [Fructose co-treated with Streptozocin] results in increased expression of ACHE protein; Metformin inhibits the reaction [[Fructose co-treated with Streptozocin] results in increased expression of ACHE protein]; vanillin inhibits the reaction [[Fructose co-treated with Streptozocin] results in increased expression of ACHE protein] CTD PMID:33823243 NCBI chr12:19,407,359...19,413,713
Ensembl chr12:19,407,360...19,413,651
JBrowse link
G Acly ATP citrate lyase increases expression EXP Fructose results in increased expression of ACLY mRNA CTD PMID:1396700 NCBI chr10:85,412,045...85,464,253
Ensembl chr10:85,412,049...85,463,320
JBrowse link
G Acox1 acyl-CoA oxidase 1 multiple interactions
decreases expression
EXP Atorvastatin inhibits the reaction [Fructose results in decreased expression of ACOX1 mRNA] CTD PMID:21122807 NCBI chr10:101,406,197...101,431,242
Ensembl chr10:101,406,197...101,431,232
JBrowse link
G Acsf2 acyl-CoA synthetase family member 2 multiple interactions EXP [Fructose co-treated with bisphenol A] results in increased expression of ACSF2 protein CTD PMID:26930160 NCBI chr10:79,504,510...79,546,714
Ensembl chr10:79,504,511...79,546,673
JBrowse link
G Acta2 actin alpha 2, smooth muscle increases expression
multiple interactions
EXP Fructose results in increased expression of ACTA2 protein
[Streptozocin co-treated with Fructose] results in increased expression of ACTA2 protein; dapagliflozin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of ACTA2 protein]; Genistein inhibits the reaction [Fructose results in increased expression of ACTA2 protein]; Metformin promotes the reaction [dapagliflozin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of ACTA2 protein]]
CTD PMID:21704028 PMID:30551545 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
JBrowse link
G Ada adenosine deaminase multiple interactions
increases activity
EXP Glutamine inhibits the reaction [Fructose results in increased activity of ADA protein] CTD PMID:31233715 NCBI chr 3:152,398,745...152,422,854
Ensembl chr 3:152,398,747...152,447,088
JBrowse link
G Adgre1 adhesion G protein-coupled receptor E1 multiple interactions
increases expression
EXP
ISO
[gadolinium chloride co-treated with Fructose co-treated with Copper deficiency] results in decreased expression of ADGRE1 mRNA
Fructose results in increased expression of ADGRE1 protein
Ethanol promotes the reaction [Fructose results in increased expression of ADGRE1 protein]; Fructose promotes the reaction [Ethanol results in increased expression of ADGRE1 mRNA]; Fructose promotes the reaction [Ethanol results in increased expression of ADGRE1 protein]
CTD PMID:25813056 PMID:26858005 NCBI chr 9:2,242,476...2,398,000
Ensembl chr 9:2,242,474...2,398,000
JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing multiple interactions
decreases secretion
increases secretion
decreases expression
increases expression
EXP
ISO
[Particulate Matter co-treated with Ozone] promotes the reaction [Fructose results in decreased expression of ADIPOQ mRNA]; Curcumin inhibits the reaction [Fructose results in decreased expression of ADIPOQ protein]; geraniol inhibits the reaction [Fructose results in decreased secretion of ADIPOQ protein]; Metformin inhibits the reaction [Fructose results in decreased expression of ADIPOQ protein]; Ozone promotes the reaction [Fructose results in decreased expression of ADIPOQ mRNA]; Particulate Matter promotes the reaction [Fructose results in decreased expression of ADIPOQ mRNA]; Pioglitazone inhibits the reaction [Fructose results in decreased secretion of ADIPOQ protein]; Resveratrol inhibits the reaction [Fructose results in decreased expression of ADIPOQ mRNA]; Resveratrol inhibits the reaction [Fructose results in decreased expression of ADIPOQ protein]; sapropterin inhibits the reaction [Fructose results in decreased expression of ADIPOQ mRNA]; sapropterin inhibits the reaction [Fructose results in decreased expression of ADIPOQ protein]
Fructose results in increased secretion of ADIPOQ protein
Fructose results in decreased expression of ADIPOQ mRNA; Fructose results in decreased expression of ADIPOQ protein
Fructose results in increased expression of ADIPOQ mRNA; Fructose results in increased expression of ADIPOQ protein
CTD PMID:17098227 PMID:19165636 PMID:21122807 PMID:23016136 PMID:23968387 More... NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564
JBrowse link
G Adipor2 adiponectin receptor 2 decreases expression ISO Fructose results in decreased expression of ADIPOR2 protein CTD PMID:28257781 NCBI chr 4:152,524,604...152,588,848
Ensembl chr 4:152,524,623...152,559,355
JBrowse link
G Ager advanced glycosylation end product-specific receptor increases expression
multiple interactions
EXP Fructose results in increased expression of AGER protein
Genistein inhibits the reaction [Fructose results in increased expression of AGER protein]; geraniol inhibits the reaction [Fructose results in increased expression of AGER protein]; Pioglitazone inhibits the reaction [Fructose results in increased expression of AGER protein]
CTD PMID:21704028 PMID:25679220 NCBI chr20:4,148,150...4,151,361
Ensembl chr20:4,147,890...4,151,078
JBrowse link
G Agt angiotensinogen increases expression
multiple interactions
EXP
ISO
Fructose results in increased expression of AGT mRNA; Fructose results in increased expression of AGT protein; Fructose results in increased expression of AGT protein modified form
APLN protein modified form inhibits the reaction [Fructose results in increased expression of AGT mRNA]; APLN protein modified form inhibits the reaction [Fructose results in increased expression of AGT protein modified form]; APLN protein modified form inhibits the reaction [Fructose results in increased expression of AGT protein]
CTD PMID:11741341 PMID:16843071 PMID:17587757 PMID:18360027 PMID:30710622 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
JBrowse link
G Agtr1a angiotensin II receptor, type 1a multiple interactions
increases expression
EXP
ISO
APLN protein modified form inhibits the reaction [Fructose results in increased expression of AGTR1A mRNA]; INS protein inhibits the reaction [Fructose results in increased expression of AGTR1A mRNA]
Fructose results in increased expression of AGTR1 mRNA
CTD PMID:16843071 PMID:17587757 PMID:18360027 PMID:30710622 PMID:31655124 NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946
JBrowse link
G Agtr1b angiotensin II receptor, type 1b increases expression
multiple interactions
EXP Fructose results in increased expression of AGTR1B mRNA
KLK1 protein inhibits the reaction [Fructose results in increased expression of AGTR1B mRNA]
CTD PMID:14568997 NCBI chr 2:102,844,969...102,920,232
Ensembl chr 2:102,844,969...102,920,232
JBrowse link
G Agtr2 angiotensin II receptor, type 2 multiple interactions
increases expression
EXP APLN protein modified form inhibits the reaction [Fructose results in increased expression of AGTR2 mRNA] CTD PMID:30710622 NCBI chr  X:112,119,673...112,124,060
Ensembl chr  X:112,120,228...112,124,057
JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions ISO [Dietary Fats co-treated with Fructose] results in increased expression of AHR mRNA; AHR protein results in increased susceptibility to [Dietary Fats co-treated with Fructose]; NR0B2 protein inhibits the reaction [AHR protein results in increased susceptibility to [Dietary Fats co-treated with Fructose]]; PEMT protein promotes the reaction [AHR protein results in increased susceptibility to [Dietary Fats co-treated with Fructose]] CTD PMID:29416063 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
JBrowse link
G Akr1b1 aldo-keto reductase family 1 member B multiple interactions EXP [Fructose co-treated with bisphenol A] results in increased expression of AKR1B1 protein CTD PMID:26930160 NCBI chr 4:62,932,033...62,946,126
Ensembl chr 4:62,932,031...62,946,157
JBrowse link
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation
increases phosphorylation
multiple interactions
EXP Fructose results in decreased phosphorylation of AKT1 protein
Fructose results in increased phosphorylation of AKT1 protein
[dapagliflozin co-treated with Atorvastatin] inhibits the reaction [[Fructose co-treated with Dietary Fats] results in decreased expression of AKT1 protein]; [Fructose co-treated with Dietary Fats] results in decreased expression of and results in decreased phosphorylation of AKT1 protein; [Fructose co-treated with Oleanolic Acid] results in increased expression of AKT1 mRNA; NOS3 protein inhibits the reaction [Fructose results in decreased phosphorylation of AKT1 protein]; Quercetin inhibits the reaction [Fructose results in decreased phosphorylation of AKT1 protein]; Quercetin inhibits the reaction [Fructose results in increased phosphorylation of AKT1 protein]; Rutin inhibits the reaction [Fructose results in decreased phosphorylation of AKT1 protein]
CTD PMID:18497449 PMID:19008412 PMID:22426011 PMID:23533474 PMID:24704288 More... NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Aldob aldolase, fructose-bisphosphate B increases expression
multiple interactions
ISO
EXP
Fructose results in increased expression of ALDOB mRNA
FGF21 gene mutant form inhibits the reaction [Fructose results in increased expression of ALDOB mRNA]
CTD PMID:15066988 PMID:18346472 PMID:28123933 NCBI chr 5:63,889,045...63,902,086
Ensembl chr 5:63,889,046...63,902,116
JBrowse link
G Alox5 arachidonate 5-lipoxygenase increases expression ISO Fructose results in increased expression of ALOX5 mRNA CTD PMID:31655124 NCBI chr 4:149,531,329...149,578,696
Ensembl chr 4:149,531,515...149,578,743
JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 multiple interactions ISO [Fructose co-treated with Dietary Fats] results in increased expression of APAF1 mRNA; troxerutin inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of APAF1 mRNA] CTD PMID:28916335 NCBI chr 7:25,494,143...25,579,540
Ensembl chr 7:25,494,609...25,579,540
JBrowse link
G Apln apelin multiple interactions EXP APLN protein modified form inhibits the reaction [Fructose results in decreased activity of CAT protein]; APLN protein modified form inhibits the reaction [Fructose results in decreased expression of APLNR mRNA]; APLN protein modified form inhibits the reaction [Fructose results in increased expression of ACE mRNA]; APLN protein modified form inhibits the reaction [Fructose results in increased expression of AGT mRNA]; APLN protein modified form inhibits the reaction [Fructose results in increased expression of AGT protein modified form]; APLN protein modified form inhibits the reaction [Fructose results in increased expression of AGT protein]; APLN protein modified form inhibits the reaction [Fructose results in increased expression of AGTR1A mRNA]; APLN protein modified form inhibits the reaction [Fructose results in increased expression of AGTR2 mRNA] CTD PMID:30710622 NCBI chr  X:127,180,801...127,213,567
Ensembl chr  X:127,203,823...127,213,391
JBrowse link
G Aplnr apelin receptor decreases expression
multiple interactions
EXP Fructose results in decreased expression of APLNR mRNA
APLN protein modified form inhibits the reaction [Fructose results in decreased expression of APLNR mRNA]
CTD PMID:30710622 NCBI chr 3:70,217,407...70,221,052
Ensembl chr 3:70,217,385...70,221,050
JBrowse link
G Apoa1 apolipoprotein A1 increases expression
multiple interactions
decreases expression
EXP
ISO
Fructose results in increased expression of APOA1 mRNA; Fructose results in increased expression of APOA1 protein
Plant Preparations inhibits the reaction [Fructose results in decreased expression of APOA1 protein]
[bisphenol A co-treated with Fructose] results in increased expression of APOA1 protein
CTD PMID:9322794 PMID:23142792 PMID:27531227 NCBI chr 8:46,527,251...46,529,035
Ensembl chr 8:46,527,144...46,529,035
JBrowse link
G Apoa4 apolipoprotein A4 increases expression ISO Fructose results in increased expression of APOA4 mRNA CTD PMID:11983814 NCBI chr 8:46,539,083...46,541,464
Ensembl chr 8:46,539,082...46,541,469
JBrowse link
G Apob apolipoprotein B multiple interactions
increases expression
EXP
ISO
[Fructose co-treated with Copper deficiency] results in decreased expression of APOB mRNA; Atorvastatin inhibits the reaction [Fructose results in increased expression of APOB protein]; gadolinium chloride promotes the reaction [[Fructose co-treated with Copper deficiency] results in decreased expression of APOB mRNA]
[FGF21 gene mutant form results in increased susceptibility to Fructose] which results in decreased expression of APOB mRNA; Plant Preparations inhibits the reaction [Fructose results in increased expression of APOB protein]
Fructose results in increased expression of APOB mRNA; Fructose results in increased expression of APOB protein
CTD PMID:8415773 PMID:12065722 PMID:25813056 PMID:27531227 PMID:28123933 NCBI chr 6:30,844,386...30,883,983
Ensembl chr 6:30,844,368...30,892,497
JBrowse link
G Atf4 activating transcription factor 4 increases expression EXP Fructose results in increased expression of ATF4 mRNA CTD PMID:15150374 NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446
JBrowse link
G Atp1b1 ATPase Na+/K+ transporting subunit beta 1 decreases expression EXP Fructose results in decreased expression of ATP1B1 protein CTD PMID:26930160 NCBI chr13:76,786,580...76,807,096
Ensembl chr13:76,786,578...76,807,459
JBrowse link
G Atp2a2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 multiple interactions ISO [Fructose co-treated with Dietary Fats] results in decreased expression of ATP2A2 mRNA; troxerutin inhibits the reaction [[Fructose co-treated with Dietary Fats] results in decreased expression of ATP2A2 mRNA] CTD PMID:28916335 NCBI chr12:34,072,710...34,122,142
Ensembl chr12:34,072,683...34,122,101
JBrowse link
G Atp5mf ATP synthase membrane subunit f multiple interactions
increases expression
EXP [Fructose co-treated with bisphenol A] results in decreased expression of ATP5MF protein
Fructose results in increased expression of ATP5MF protein
CTD PMID:26930160 NCBI chr12:9,421,665...9,428,236
Ensembl chr12:9,421,579...9,428,236
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression
multiple interactions
ISO Fructose results in increased expression of BAX protein
[Fructose co-treated with Dietary Fats] results in increased expression of BAX mRNA; [Fructose co-treated with Dietary Fats] results in increased expression of BAX protein; Plant Preparations inhibits the reaction [Fructose results in increased expression of BAX protein]; troxerutin inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of BAX mRNA]; troxerutin inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of BAX protein]
CTD PMID:27531227 PMID:28916335 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
increases expression
multiple interactions
ISO
EXP
Fructose results in decreased expression of BCL2 protein
Fructose results in increased expression of BCL2 mRNA
[Atorvastatin co-treated with dapagliflozin] inhibits the reaction [[Fructose co-treated with Dietary Fats] results in decreased expression of BCL2 protein]; [Fructose co-treated with Dietary Fats] results in decreased expression of BCL2 protein; dapagliflozin inhibits the reaction [[Fructose co-treated with Dietary Fats] results in decreased expression of BCL2 protein]; Kangen-karyu inhibits the reaction [Fructose results in increased expression of BCL2 protein]
[Fructose co-treated with Dietary Fats] results in decreased expression of BCL2 mRNA; [Fructose co-treated with Dietary Fats] results in decreased expression of BCL2 protein; troxerutin inhibits the reaction [[Fructose co-treated with Dietary Fats] results in decreased expression of BCL2 mRNA]; troxerutin inhibits the reaction [[Fructose co-treated with Dietary Fats] results in decreased expression of BCL2 protein]
CTD PMID:17883899 PMID:27531227 PMID:28916335 PMID:31655124 PMID:32259528 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Calca calcitonin-related polypeptide alpha increases expression ISO Fructose results in increased expression of CALCA mRNA CTD PMID:31655124 NCBI chr 1:168,878,212...168,883,176
Ensembl chr 1:168,878,214...168,883,105
JBrowse link
G Casp1 caspase 1 multiple interactions
increases expression
EXP Allopurinol inhibits the reaction [Fructose results in increased expression of CASP1 protein modified form]; Allopurinol inhibits the reaction [Fructose results in increased expression of CASP1 protein]; Quercetin inhibits the reaction [Fructose results in increased expression of CASP1 protein modified form]; Quercetin inhibits the reaction [Fructose results in increased expression of CASP1 protein]; Rutin inhibits the reaction [Fructose results in increased expression of CASP1 protein]
Fructose results in increased expression of CASP1 protein; Fructose results in increased expression of CASP1 protein modified form
CTD PMID:22426011 PMID:24491314 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383
JBrowse link
G Casp3 caspase 3 multiple interactions
decreases expression
increases expression
ISO
EXP
[Fructose co-treated with Dietary Fats] results in increased expression of CASP3 mRNA; [Fructose co-treated with Dietary Fats] results in increased expression of CASP3 protein; troxerutin inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of CASP3 mRNA]; troxerutin inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of CASP3 protein]
[Fructose co-treated with Palmitic Acid] results in increased activity of CASP3 protein; Fenofibrate inhibits the reaction [[Fructose co-treated with Palmitic Acid] results in increased activity of CASP3 protein]
Fructose results in decreased expression of CASP3 mRNA
imoxin inhibits the reaction [Fructose results in increased expression of CASP3 protein]
CTD PMID:28916335 PMID:29430716 PMID:31655124 PMID:32730863 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp7 caspase 7 multiple interactions EXP [Streptozocin co-treated with Fructose] results in increased expression of CASP7 protein; dapagliflozin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of CASP7 protein]; dapagliflozin promotes the reaction [Metformin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of CASP7 protein]]; Metformin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of CASP7 protein]; Metformin promotes the reaction [dapagliflozin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of CASP7 protein]] CTD PMID:30551545 NCBI chr 1:255,437,195...255,476,737
Ensembl chr 1:255,437,172...255,476,729
JBrowse link
G Casp9 caspase 9 multiple interactions ISO [Fructose co-treated with Dietary Fats] results in increased expression of CASP9 mRNA; [Fructose co-treated with Dietary Fats] results in increased expression of CASP9 protein; troxerutin inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of CASP9 mRNA]; troxerutin inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of CASP9 protein] CTD PMID:28916335 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Cat catalase decreases expression
multiple interactions
decreases activity
EXP
ISO
Fructose results in decreased expression of CAT mRNA; Fructose results in decreased expression of CAT protein
[Fructose co-treated with Dietary Fats] results in decreased activity of CAT protein; troxerutin inhibits the reaction [[Fructose co-treated with Dietary Fats] results in decreased activity of CAT protein]
[Fructose co-treated with Streptozocin] results in decreased activity of CAT protein; [Hydrochlorothiazide co-treated with Fructose] results in decreased activity of CAT protein; APLN protein modified form inhibits the reaction [Fructose results in decreased activity of CAT protein]; Metformin inhibits the reaction [[Fructose co-treated with Streptozocin] results in decreased activity of CAT protein]; vanillin inhibits the reaction [[Fructose co-treated with Streptozocin] results in decreased activity of CAT protein]
CTD PMID:11817707 PMID:20470786 PMID:23707192 PMID:28916335 PMID:30710622 More... NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Cavin3 caveolae associated protein 3 multiple interactions EXP [Fructose co-treated with bisphenol A] results in increased expression of CAVIN3 protein CTD PMID:26930160 NCBI chr 1:159,826,549...159,828,138
Ensembl chr 1:159,826,549...159,828,161
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions
increases expression
increases secretion
ISO
EXP
[Fructose co-treated with Uric Acid] results in increased secretion of CCL2 protein; acetovanillone inhibits the reaction [Fructose results in increased secretion of CCL2 protein]; Acetylcysteine inhibits the reaction [Fructose results in increased secretion of CCL2 protein]; Allopurinol inhibits the reaction [[Fructose co-treated with Uric Acid] results in increased secretion of CCL2 protein]; Allopurinol inhibits the reaction [Fructose results in increased secretion of CCL2 protein]; Glucose inhibits the reaction [Fructose results in increased secretion of CCL2 protein]; KHK protein promotes the reaction [Fructose results in increased secretion of CCL2 protein]; Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin inhibits the reaction [Fructose results in increased secretion of CCL2 protein]; Superoxides affects the reaction [Fructose results in increased secretion of CCL2 protein]
Fructose results in increased expression of CCL2 mRNA
Fructose results in increased expression of CCL2 protein
[Dietary Fats co-treated with Fructose] results in increased expression of CCL2 protein; [FGF21 gene mutant form results in increased susceptibility to Fructose] which results in increased expression of CCL2 mRNA; [Fructose co-treated with Ethanol] results in increased expression of CCL2 mRNA; sarpogrelate inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of CCL2 protein]
[Copper deficiency co-treated with Fructose] results in increased expression of CCL2 protein; [Fructose co-treated with Copper deficiency] results in increased expression of CCL2 protein; [Lipopolysaccharides co-treated with Fructose co-treated with Copper deficiency] results in increased expression of CCL2 protein; [Particulate Matter co-treated with Ozone] promotes the reaction [Fructose results in increased expression of CCL2 mRNA]; [Streptozocin co-treated with Fructose] results in increased expression of and results in increased secretion of CCL2 protein; Acarbose inhibits the reaction [Fructose results in increased expression of CCL2 mRNA]; Acarbose inhibits the reaction [Fructose results in increased expression of CCL2 protein]; dapagliflozin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of and results in increased secretion of CCL2 protein]; Deferiprone inhibits the reaction [[Lipopolysaccharides co-treated with Fructose co-treated with Copper deficiency] results in increased expression of CCL2 protein]; Deferoxamine inhibits the reaction [[Lipopolysaccharides co-treated with Fructose co-treated with Copper deficiency] results in increased expression of CCL2 protein]; Fish Oils inhibits the reaction [Fructose results in increased expression of CCL2 protein]; gadolinium chloride inhibits the reaction [[Fructose co-treated with Copper deficiency] results in increased expression of CCL2 protein]; Metformin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of and results in increased secretion of CCL2 protein]; Ozone promotes the reaction [Fructose results in increased expression of CCL2 mRNA]; Particulate Matter promotes the reaction [Fructose results in increased expression of CCL2 mRNA]
Fructose results in increased expression of CCL2 mRNA; Fructose results in increased expression of CCL2 protein
CTD PMID:15752949 PMID:17133782 PMID:19158351 PMID:21781943 PMID:23968387 More... NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Ccl3 C-C motif chemokine ligand 3 multiple interactions ISO [FGF21 gene mutant form results in increased susceptibility to Fructose] which results in increased expression of CCL3 mRNA CTD PMID:28123933 NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938
JBrowse link
G Ccn2 cellular communication network factor 2 multiple interactions
increases expression
EXP betanin inhibits the reaction [Fructose results in increased expression of CCN2 protein] CTD PMID:25559852 NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734
JBrowse link
G Cd163 CD163 molecule multiple interactions EXP
ISO
[gadolinium chloride co-treated with Fructose co-treated with Copper deficiency] results in decreased expression of CD163 mRNA
[Fructose co-treated with Ethanol] results in increased expression of CD163 mRNA
CTD PMID:25813056 PMID:26858005 NCBI chr 4:157,085,080...157,118,470
Ensembl chr 4:157,085,093...157,117,878
JBrowse link
G Cd36 CD36 molecule decreases expression
multiple interactions
ISO
EXP
Fructose results in decreased expression of CD36 protein
[Atorvastatin co-treated with dapagliflozin] inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of CD36 protein]; [Fructose co-treated with Dietary Fats] results in increased expression of CD36 protein; dapagliflozin inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of CD36 protein]
CTD PMID:28257781 PMID:32259528 NCBI chr 4:17,317,343...17,410,084 JBrowse link
G Cd68 Cd68 molecule multiple interactions EXP
ISO
[Dietary Fats co-treated with Fructose] results in increased expression of CD68 mRNA; [gadolinium chloride co-treated with Fructose co-treated with Copper deficiency] results in decreased expression of CD68 mRNA; [gadolinium chloride co-treated with Fructose co-treated with Copper deficiency] results in decreased expression of CD68 protein
[FGF21 gene mutant form results in increased susceptibility to Fructose] which results in increased expression of CD68 mRNA; [Fructose co-treated with Ethanol] results in increased expression of CD68 mRNA
CTD PMID:19632207 PMID:25813056 PMID:26858005 PMID:28123933 NCBI chr10:54,381,814...54,383,693
Ensembl chr10:54,381,815...54,383,697
JBrowse link
G Chrm2 cholinergic receptor, muscarinic 2 increases expression EXP Fructose results in increased expression of CHRM2 mRNA; Fructose results in increased expression of CHRM2 protein CTD PMID:17707055 NCBI chr 4:65,015,408...65,149,104
Ensembl chr 4:65,014,144...65,149,103
JBrowse link
G Chrm3 cholinergic receptor, muscarinic 3 increases expression EXP Fructose results in increased expression of CHRM3 mRNA; Fructose results in increased expression of CHRM3 protein CTD PMID:17707055 NCBI chr17:60,005,137...60,467,250
Ensembl chr17:60,005,202...60,467,278
JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex increases phosphorylation
multiple interactions
EXP Fructose results in increased phosphorylation of CHUK protein
Quercetin inhibits the reaction [Fructose results in increased phosphorylation of CHUK protein]
CTD PMID:24491314 NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:242,959,760...242,995,065
JBrowse link
G Cidea cell death-inducing DFFA-like effector a multiple interactions
decreases expression
EXP [Ozone co-treated with Fructose] results in decreased expression of CIDEA mRNA; [Particulate Matter co-treated with Fructose] results in decreased expression of CIDEA mRNA; [Particulate Matter co-treated with Ozone co-treated with Fructose] results in decreased expression of CIDEA mRNA
Fructose results in decreased expression of CIDEA mRNA
CTD PMID:23968387 NCBI chr18:60,894,917...60,920,485
Ensembl chr18:60,894,874...60,920,481
JBrowse link
G Cnr1 cannabinoid receptor 1 increases expression
multiple interactions
EXP Fructose results in increased expression of CNR1 mRNA
[Fructose co-treated with Streptozocin] results in decreased expression of CNR1 mRNA; Ghrelin inhibits the reaction [[Fructose co-treated with Streptozocin] results in decreased expression of CNR1 mRNA]
CTD PMID:18627777 PMID:31468622 NCBI chr 5:48,408,543...48,436,099
Ensembl chr 5:48,408,574...48,435,099
JBrowse link
G Coq9 coenzyme Q9 multiple interactions EXP [Fructose co-treated with bisphenol A] results in increased expression of COQ9 protein CTD PMID:26930160 NCBI chr19:10,166,948...10,179,976
Ensembl chr19:10,166,951...10,179,949
JBrowse link
G Cp ceruloplasmin multiple interactions EXP [Fructose co-treated with Copper deficiency] results in decreased activity of CP protein; Fructose promotes the reaction [Copper deficiency results in decreased expression of CP protein] CTD PMID:21781943 PMID:25813056 NCBI chr 2:102,439,433...102,498,075
Ensembl chr 2:102,439,624...102,498,075
JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A multiple interactions EXP [Dietary Fats co-treated with Fructose] results in increased expression of CPT1A mRNA; [Fructose co-treated with Copper deficiency] results in decreased expression of CPT1A mRNA; [Fructose co-treated with Dietary Fats] results in decreased expression of CPT1A protein CTD PMID:19632207 PMID:25813056 PMID:32259528 NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055
JBrowse link
G Creb1 cAMP responsive element binding protein 1 increases expression
multiple interactions
EXP Fructose results in increased expression of CREB1 mRNA; Fructose results in increased expression of CREB1 protein
rosiglitazone inhibits the reaction [Fructose results in increased expression of CREB1 mRNA]; rosiglitazone inhibits the reaction [Fructose results in increased expression of CREB1 protein]
CTD PMID:19196556 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
JBrowse link
G Crp C-reactive protein multiple interactions
increases expression
EXP
ISO
[Dietary Fats co-treated with Fructose] results in increased expression of CRP mRNA; Curcumin inhibits the reaction [Fructose results in increased expression of CRP protein]; Metformin inhibits the reaction [Fructose results in increased expression of CRP protein]; resveratrol inhibits the reaction [Fructose results in increased expression of CRP protein] CTD PMID:19632207 PMID:25108154 PMID:26713546 PMID:31672515 NCBI chr13:85,131,635...85,175,179
Ensembl chr13:85,124,977...85,175,178
JBrowse link
G Cst3 cystatin C multiple interactions EXP [Streptozocin co-treated with Fructose] results in increased expression of CST3 protein; Metformin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of CST3 protein] CTD PMID:30551545 NCBI chr 3:136,336,923...136,340,796
Ensembl chr 3:136,336,920...136,340,822
JBrowse link
G Cx3cl1 C-X3-C motif chemokine ligand 1 increases expression ISO Fructose results in increased expression of CX3CL1 mRNA CTD PMID:31655124 NCBI chr19:10,227,337...10,237,826
Ensembl chr19:10,227,340...10,236,833
JBrowse link
G Cybb cytochrome b-245 beta chain multiple interactions EXP [Dietary Fats co-treated with Fructose] results in increased expression of CYBB mRNA CTD PMID:19632207 NCBI chr  X:13,360,583...13,392,517
Ensembl chr  X:13,359,430...13,392,586
JBrowse link
G Cycs cytochrome c, somatic multiple interactions EXP
ISO
[Atorvastatin co-treated with dapagliflozin] inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of CYCS protein]; [Fructose co-treated with Dietary Fats] results in increased expression of CYCS protein
[Fructose co-treated with Palmitic Acid] results in increased expression of CYCS protein; Fenofibrate inhibits the reaction [[Fructose co-treated with Palmitic Acid] results in increased expression of CYCS protein]
CTD PMID:32259528 PMID:32730863 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO [Dietary Fats co-treated with Fructose] results in increased expression of CYP1A1 mRNA CTD PMID:26102010 PMID:29416063 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions ISO [Dietary Fats co-treated with Fructose] results in increased expression of CYP1A2 mRNA; alpha-Tocopherol inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of CYP1A2 mRNA]; tetrahydrocurcumin inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of CYP1A2 mRNA] CTD PMID:26102010 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 multiple interactions ISO [Dietary Fats co-treated with Fructose] results in increased expression of CYP1B1 mRNA; [Dietary Fats co-treated with Fructose] results in increased expression of CYP1B1 protein; tetrahydrocurcumin inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of CYP1B1 mRNA]; tetrahydrocurcumin inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of CYP1B1 protein] CTD PMID:26102010 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 multiple interactions ISO [Dietary Fats co-treated with Fructose] results in increased expression of CYP2C29 mRNA; [Dietary Fats co-treated with Fructose] results in increased expression of CYP2C29 protein; alpha-Tocopherol inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of CYP2C29 protein]; tetrahydrocurcumin inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of CYP2C29 mRNA]; tetrahydrocurcumin inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of CYP2C29 protein] CTD PMID:26102010
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 decreases expression
increases expression
multiple interactions
ISO Fructose results in decreased expression of CYP2E1 protein
Fructose results in increased expression of CYP2E1 protein
Ethanol promotes the reaction [Fructose results in increased expression of CYP2E1 protein]
CTD PMID:26858005 PMID:28257781 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
JBrowse link
G Cyp4a1 cytochrome P450, family 4, subfamily a, polypeptide 1 multiple interactions EXP [Fructose co-treated with Copper deficiency] results in decreased expression of CYP4A1 mRNA; gadolinium chloride promotes the reaction [[Fructose co-treated with Copper deficiency] results in decreased expression of CYP4A1 mRNA] CTD PMID:25813056 NCBI chr 5:129,123,323...129,137,464
Ensembl chr 5:129,123,336...129,137,464
JBrowse link
G Ddt D-dopachrome tautomerase decreases expression
multiple interactions
EXP Fructose results in decreased expression of DDT protein
[Fructose co-treated with bisphenol A] results in increased expression of DDT protein
CTD PMID:26930160 NCBI chr20:12,884,216...12,886,687
Ensembl chr20:12,884,243...12,888,482
JBrowse link
G Dek DEK proto-oncogene multiple interactions ISO DEK protein results in decreased chemical synthesis of and results in decreased secretion of Fructose CTD PMID:28558019 NCBI chr17:17,580,804...17,602,825
Ensembl chr17:17,580,843...17,602,808
JBrowse link
G Dgat1 diacylglycerol O-acyltransferase 1 multiple interactions ISO [FGF21 gene mutant form results in increased susceptibility to Fructose] which results in increased expression of DGAT1 mRNA CTD PMID:28123933 NCBI chr 7:108,223,860...108,235,413
Ensembl chr 7:108,218,524...108,234,299
JBrowse link
G Dgat2 diacylglycerol O-acyltransferase 2 multiple interactions ISO [FGF21 gene mutant form results in increased susceptibility to Fructose] which results in decreased expression of DGAT2 mRNA CTD PMID:28123933 NCBI chr 1:153,454,078...153,484,432
Ensembl chr 1:153,454,080...153,484,428
JBrowse link
G Dld dihydrolipoamide dehydrogenase multiple interactions EXP [Fructose co-treated with bisphenol A] results in decreased expression of DLD protein CTD PMID:26930160 NCBI chr 6:47,904,153...47,924,814
Ensembl chr 6:47,903,914...47,924,795
JBrowse link
G Dnm1l dynamin 1-like multiple interactions ISO [Fructose co-treated with Palmitic Acid] results in increased expression of DNM1L protein; Fenofibrate inhibits the reaction [[Fructose co-treated with Palmitic Acid] results in increased expression of DNM1L protein] CTD PMID:32730863 NCBI chr11:84,581,216...84,632,382
Ensembl chr11:84,581,216...84,631,482
JBrowse link
G Dpt dermatopontin multiple interactions
decreases expression
EXP [Ozone co-treated with Fructose] results in decreased expression of DPT mRNA; [Particulate Matter co-treated with Fructose] results in decreased expression of DPT mRNA; Fructose affects the reaction [[Ozone co-treated with Particulate Matter] results in decreased expression of DPT mRNA]
Fructose results in decreased expression of DPT mRNA
CTD PMID:23968387 NCBI chr13:77,122,926...77,151,646
Ensembl chr13:77,123,115...77,151,639
JBrowse link
G Echs1 enoyl-CoA hydratase, short chain 1 multiple interactions EXP [Fructose co-treated with bisphenol A] results in increased expression of ECHS1 protein CTD PMID:26930160 NCBI chr 1:194,895,036...194,903,863
Ensembl chr 1:194,895,036...194,903,884
JBrowse link
G Edn1 endothelin 1 increases response to substance
increases expression
multiple interactions
EXP Fructose results in increased susceptibility to EDN1 protein
Fructose results in increased expression of EDN1 mRNA; Fructose results in increased expression of EDN1 protein modified form
KLK1 protein inhibits the reaction [Fructose results in increased expression of EDN1 mRNA]; Metformin inhibits the reaction [Fructose results in increased expression of EDN1 protein]; resveratrol inhibits the reaction [Fructose results in increased expression of EDN1 protein]
CTD PMID:9869011 PMID:11172478 PMID:14568997 PMID:25108154 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
JBrowse link
G Ednra endothelin receptor type A multiple interactions
increases expression
EXP
ISO
KLK1 protein inhibits the reaction [Fructose results in increased expression of EDNRA mRNA] CTD PMID:9869011 PMID:14568997 PMID:31655124 NCBI chr19:30,233,540...30,303,727
Ensembl chr19:30,233,571...30,297,049
JBrowse link
G Eef1a2 eukaryotic translation elongation factor 1 alpha 2 multiple interactions EXP [Fructose co-treated with bisphenol A] results in decreased expression of EEF1A2 protein CTD PMID:26930160 NCBI chr 3:168,265,893...168,275,071 JBrowse link
G Egf epidermal growth factor multiple interactions
increases uptake
EXP wortmannin inhibits the reaction [EGF protein results in increased uptake of Fructose] CTD PMID:15691865 NCBI chr 2:218,219,408...218,302,370
Ensembl chr 2:218,219,415...218,302,064
JBrowse link
G Eif2ak2 eukaryotic translation initiation factor 2-alpha kinase 2 increases expression
multiple interactions
EXP Fructose results in increased expression of EIF2AK2 protein
imoxin inhibits the reaction [Fructose results in increased expression of EIF2AK2 protein]
CTD PMID:29430716 NCBI chr 6:16,189,000...16,224,972
Ensembl chr 6:16,188,979...16,224,971
JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 increases phosphorylation
multiple interactions
ISO Fructose results in increased phosphorylation of EIF2AK3 protein
Phenylbutyrates inhibits the reaction [Fructose results in increased phosphorylation of EIF2AK3 protein]
CTD PMID:22698815 NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911
JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha increases phosphorylation
multiple interactions
ISO Fructose results in increased phosphorylation of EIF2S1 protein
Phenylbutyrates inhibits the reaction [Fructose results in increased phosphorylation of EIF2S1 protein]
CTD PMID:22698815 NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225
JBrowse link
G Elovl6 ELOVL fatty acid elongase 6 increases expression ISO Fructose results in increased expression of ELOVL6 mRNA CTD PMID:15066988 NCBI chr 2:218,063,682...218,174,767
Ensembl chr 2:218,063,804...218,171,186
JBrowse link
G Entpd2 ectonucleoside triphosphate diphosphohydrolase 2 decreases expression EXP Fructose results in decreased expression of ENTPD2 mRNA CTD PMID:15150374 NCBI chr 3:8,213,575...8,219,094
Ensembl chr 3:8,213,663...8,226,866
JBrowse link
G Ezr ezrin multiple interactions EXP [Fructose co-treated with bisphenol A] results in increased expression of EZR protein CTD PMID:26930160 NCBI chr 1:46,967,961...47,011,505
Ensembl chr 1:46,967,658...47,011,505
JBrowse link
G F3 coagulation factor III, tissue factor increases expression ISO Fructose results in increased expression of F3 mRNA CTD PMID:31655124 NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668
JBrowse link
G Fabp3 fatty acid binding protein 3 multiple interactions EXP [Fructose co-treated with bisphenol A] results in increased expression of FABP3 protein CTD PMID:26930160 NCBI chr 5:142,651,962...142,658,707
Ensembl chr 5:142,651,956...142,658,718
JBrowse link
G Fabp4 fatty acid binding protein 4 multiple interactions EXP [Fructose co-treated with bisphenol A] results in increased expression of FABP4 protein CTD PMID:26930160 NCBI chr 2:91,580,858...91,585,578
Ensembl chr 2:91,580,885...91,585,578
JBrowse link
G Fas Fas cell surface death receptor decreases expression ISO Fructose results in decreased expression of FAS mRNA CTD PMID:31655124 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
JBrowse link
G Faslg Fas ligand increases expression ISO Fructose results in increased expression of FASLG mRNA CTD PMID:31655124 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215
JBrowse link
G Fasn fatty acid synthase multiple interactions
increases expression
increases activity
EXP
ISO
[Atorvastatin co-treated with dapagliflozin] inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of FASN protein]; [Copper deficiency co-treated with Fructose] results in increased expression of FASN protein; [Fenofibrate co-treated with Resveratrol] inhibits the reaction [Fructose results in increased expression of FASN mRNA]; [Fructose co-treated with Dietary Fats] results in increased expression of FASN protein; [gadolinium chloride co-treated with Fructose co-treated with Copper deficiency] results in decreased expression of FASN mRNA; Atorvastatin inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of FASN protein]; dapagliflozin inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of FASN protein]; Fenofibrate inhibits the reaction [Fructose results in increased expression of FASN mRNA]; Resveratrol inhibits the reaction [Fructose results in increased expression of FASN mRNA]; Rosiglitazone inhibits the reaction [Fructose results in increased expression of FASN mRNA]; Tea inhibits the reaction [Fructose results in increased expression of FASN mRNA]
[Fructose co-treated with Palmitic Acid] results in increased expression of FASN protein; Fenofibrate inhibits the reaction [[Fructose co-treated with Palmitic Acid] results in increased expression of FASN protein]
FGF21 gene mutant form inhibits the reaction [Fructose results in increased expression of FASN mRNA]; Phenylbutyrates inhibits the reaction [Fructose results in increased expression of FASN mRNA]; Plant Preparations inhibits the reaction [Fructose results in increased expression of FASN protein]; SCD1 gene mutant form inhibits the reaction [Fructose results in increased expression of FASN mRNA]; Triolein inhibits the reaction [SCD1 gene mutant form inhibits the reaction [Fructose results in increased expression of FASN mRNA]]; Triolein promotes the reaction [Fructose results in increased expression of FASN mRNA]
Fructose results in increased expression of FASN mRNA; Fructose results in increased expression of FASN protein
Fructose results in increased activity of FASN protein
CTD PMID:8759368 PMID:9566986 PMID:12065722 PMID:15066988 PMID:18346472 More... NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261
JBrowse link
G Fbp1 fructose-bisphosphatase 1 increases activity
increases expression
multiple interactions
EXP Fructose results in increased activity of FBP1 protein
Fructose results in increased expression of FBP1 mRNA
Vanadates inhibits the reaction [Fructose results in increased activity of FBP1 protein]
CTD PMID:15150374 PMID:16920846 PMID:18346472 NCBI chr17:2,207,271...2,230,076
Ensembl chr17:2,208,031...2,230,071
JBrowse link
G Fgf21 fibroblast growth factor 21 multiple interactions
increases expression
increases response to substance
increases secretion
ISO [FGF21 gene mutant form results in increased susceptibility to Fructose] which results in decreased abundance of Blood Glucose; [FGF21 gene mutant form results in increased susceptibility to Fructose] which results in decreased expression of APOB mRNA; [FGF21 gene mutant form results in increased susceptibility to Fructose] which results in decreased expression of DGAT2 mRNA; [FGF21 gene mutant form results in increased susceptibility to Fructose] which results in increased expression of CCL2 mRNA; [FGF21 gene mutant form results in increased susceptibility to Fructose] which results in increased expression of CCL3 mRNA; [FGF21 gene mutant form results in increased susceptibility to Fructose] which results in increased expression of CD68 mRNA; [FGF21 gene mutant form results in increased susceptibility to Fructose] which results in increased expression of DGAT1 mRNA; [FGF21 gene mutant form results in increased susceptibility to Fructose] which results in increased expression of MMP2 mRNA; [FGF21 gene mutant form results in increased susceptibility to Fructose] which results in increased expression of TGFB1 mRNA; [FGF21 gene mutant form results in increased susceptibility to Fructose] which results in increased expression of TGFB2 mRNA; FGF21 gene mutant form inhibits the reaction [Fructose results in increased expression of ACACA mRNA]; FGF21 gene mutant form inhibits the reaction [Fructose results in increased expression of ACACB mRNA]; FGF21 gene mutant form inhibits the reaction [Fructose results in increased expression of ALDOB mRNA]; FGF21 gene mutant form inhibits the reaction [Fructose results in increased expression of FASN mRNA]; FGF21 gene mutant form inhibits the reaction [Fructose results in increased expression of KHK mRNA]; FGF21 gene mutant form inhibits the reaction [Fructose results in increased expression of MLXIPL mRNA alternative form]; FGF21 gene mutant form inhibits the reaction [Fructose results in increased expression of MTTP mRNA]; FGF21 gene mutant form inhibits the reaction [Fructose results in increased expression of PKLR mRNA]; FGF21 gene mutant form inhibits the reaction [Fructose results in increased expression of SCD1 mRNA]; FGF21 gene mutant form inhibits the reaction [Fructose results in increased secretion of very low density lipoprotein triglyceride]; MLXIPL gene mutant form inhibits the reaction [Fructose results in increased expression of FGF21 mRNA]; MLXIPL gene mutant form inhibits the reaction [Fructose results in increased secretion of FGF21 protein] CTD PMID:28123933 NCBI chr 1:96,083,495...96,084,738
Ensembl chr 1:96,083,441...96,090,454
JBrowse link
G Fhl2 four and a half LIM domains 2 multiple interactions EXP [Fructose co-treated with bisphenol A] results in decreased expression of FHL2 protein CTD PMID:26930160 NCBI chr 9:45,388,979...45,462,530
Ensembl chr 9:45,388,981...45,431,192
JBrowse link
G Fis1 fission, mitochondrial 1 multiple interactions ISO [Fructose co-treated with Palmitic Acid] results in increased expression of FIS1 protein; Fenofibrate inhibits the reaction [[Fructose co-treated with Palmitic Acid] results in increased expression of FIS1 protein] CTD PMID:32730863 NCBI chr12:19,708,558...19,723,392
Ensembl chr12:19,708,558...19,723,377
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression
EXP Dactinomycin inhibits the reaction [Fructose results in increased expression of FOS mRNA] CTD PMID:11123204 PMID:11557636 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Foxo1 forkhead box O1 multiple interactions
increases expression
EXP Fructose results in increased expression of and affects the localization of FOXO1 protein; Fructose results in increased expression of and results in increased phosphorylation of FOXO1 protein; Quercetin inhibits the reaction [Fructose results in increased expression of and affects the localization of FOXO1 protein]; Quercetin inhibits the reaction [Fructose results in increased expression of and results in increased phosphorylation of FOXO1 protein]; Rosiglitazone inhibits the reaction [Fructose results in increased expression of FOXO1 mRNA] CTD PMID:19196556 PMID:23533474 NCBI chr 2:136,312,168...136,390,603
Ensembl chr 2:136,312,168...136,387,790
JBrowse link
G Fth1 ferritin heavy chain 1 increases expression EXP Fructose results in increased expression of FTH1 protein CTD PMID:26930160 NCBI chr 1:206,627,142...206,629,430
Ensembl chr 1:206,627,103...206,725,424
JBrowse link
G G6pc1 glucose-6-phosphatase catalytic subunit 1 multiple interactions
increases expression
EXP Rosiglitazone inhibits the reaction [Fructose results in increased expression of G6PC1 mRNA]; Rosiglitazone inhibits the reaction [Fructose results in increased expression of G6PC1 protein]
Fructose results in increased expression of G6PC1 mRNA; Fructose results in increased expression of G6PC1 protein
CTD PMID:14988444 PMID:15150374 PMID:16920846 PMID:18346472 PMID:18556366 More... NCBI chr10:86,307,400...86,318,766 JBrowse link
G G6pd glucose-6-phosphate dehydrogenase increases activity
multiple interactions
decreases expression
EXP Fructose results in increased activity of G6PD protein
Glutamine inhibits the reaction [Fructose results in decreased expression of G6PD protein]
CTD PMID:18346472 PMID:31233715 NCBI chr  X:152,201,081...152,220,863
Ensembl chr  X:152,201,098...152,220,801
JBrowse link
G Gcg glucagon multiple interactions EXP GCG protein affects the reaction [Fructose affects the degradation of PKLR mRNA] CTD PMID:2414297 NCBI chr 3:47,113,914...47,122,929
Ensembl chr 3:47,113,914...47,122,929
JBrowse link
G Gck glucokinase increases activity EXP Fructose results in increased activity of GCK protein CTD PMID:20470786 NCBI chr14:80,785,060...80,829,842
Ensembl chr14:80,785,060...80,826,995
JBrowse link
G Gckr glucokinase regulator increases expression EXP Fructose results in increased expression of GCKR mRNA CTD PMID:18346472 NCBI chr 6:25,044,592...25,075,834
Ensembl chr 6:25,045,100...25,075,654
JBrowse link
G Ghrl ghrelin and obestatin prepropeptide increases expression EXP Fructose results in increased expression of GHRL protein CTD PMID:18627777 NCBI chr 4:146,865,712...146,869,621
Ensembl chr 4:146,865,712...146,869,621
JBrowse link
G Glp1r glucagon-like peptide 1 receptor multiple interactions EXP [Fructose co-treated with Streptozocin] results in decreased expression of GLP1R mRNA; Ghrelin inhibits the reaction [[Fructose co-treated with Streptozocin] results in decreased expression of GLP1R mRNA] CTD PMID:31468622 NCBI chr20:8,972,004...9,010,241
Ensembl chr20:8,972,004...9,010,241
JBrowse link
G Glul glutamate-ammonia ligase decreases expression
multiple interactions
EXP Fructose results in decreased expression of GLUL protein
Allopurinol inhibits the reaction [Fructose results in decreased expression of GLUL protein]; Quercetin inhibits the reaction [Fructose results in decreased expression of GLUL protein]
CTD PMID:24491314 NCBI chr13:65,969,064...66,035,121
Ensembl chr13:66,025,630...66,035,108
JBrowse link
G Gnat3 G protein subunit alpha transducin 3 affects response to substance ISO GNAT3 protein affects the susceptibility to Fructose CTD PMID:16740645 NCBI chr 4:17,162,500...17,212,283
Ensembl chr 4:17,162,490...17,212,283
JBrowse link
G Gnmt glycine N-methyltransferase multiple interactions ISO [Dietary Fats co-treated with Fructose] results in increased expression of GNMT mRNA CTD PMID:29416063 NCBI chr 9:14,254,675...14,258,028
Ensembl chr 9:14,254,675...14,258,434
JBrowse link
G Gpam glycerol-3-phosphate acyltransferase, mitochondrial multiple interactions
increases expression
EXP [Folic Acid affects the susceptibility to Fructose] which affects the expression of GPAM mRNA; Atorvastatin inhibits the reaction [Fructose results in increased expression of GPAM mRNA] CTD PMID:18346472 PMID:19053045 PMID:31612177 NCBI chr 1:254,106,323...254,170,755
Ensembl chr 1:254,106,331...254,142,639
JBrowse link
G Gpld1 glycosylphosphatidylinositol specific phospholipase D1 increases expression ISO Fructose results in increased expression of GPLD1 protein CTD PMID:16219662 NCBI chr17:40,084,427...40,132,035
Ensembl chr17:40,084,617...40,126,939
JBrowse link
G Gpt glutamic--pyruvic transaminase increases activity
multiple interactions
ISO
EXP
Fructose results in increased activity of GPT protein
[dapagliflozin co-treated with Atorvastatin] inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of GPT protein]; [Fructose co-treated with Dietary Fats] results in increased expression of GPT protein; Atorvastatin inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of GPT protein]; dapagliflozin inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of GPT protein]
[Fructose co-treated with Ethanol] results in increased expression of GPT protein; Plant Preparations inhibits the reaction [Fructose results in increased activity of GPT protein]
CTD PMID:26858005 PMID:27531227 PMID:32259528 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
JBrowse link
G Gpx1 glutathione peroxidase 1 decreases expression EXP Fructose results in decreased expression of GPX1 mRNA CTD PMID:16815490 PMID:20470786 NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024
JBrowse link
G Gpx4 glutathione peroxidase 4 decreases expression EXP Fructose results in decreased expression of GPX4 protein CTD PMID:21781943 NCBI chr 7:9,650,186...9,652,982
Ensembl chr 7:9,650,185...9,652,982
JBrowse link
G Gsr glutathione-disulfide reductase increases activity EXP Fructose results in increased activity of GSR protein CTD PMID:17710547 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
JBrowse link
G Hamp hepcidin antimicrobial peptide multiple interactions EXP [Fructose co-treated with Copper deficiency] results in decreased expression of HAMP protein CTD PMID:25813056 NCBI chr 1:86,170,926...86,172,865
Ensembl chr 1:86,170,901...86,172,891
JBrowse link
G Havcr1 hepatitis A virus cellular receptor 1 multiple interactions EXP [Streptozocin co-treated with Fructose] results in increased expression of HAVCR1 protein; dapagliflozin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of HAVCR1 protein]; dapagliflozin promotes the reaction [Metformin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of HAVCR1 protein]]; Metformin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of HAVCR1 protein]; Metformin promotes the reaction [dapagliflozin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of HAVCR1 protein]] CTD PMID:30551545 NCBI chr10:31,118,667...31,151,730
Ensembl chr10:31,119,088...31,151,698
JBrowse link
G Hbb hemoglobin subunit beta multiple interactions EXP Fructose promotes the reaction [Glucose binds to HBB protein]; geraniol inhibits the reaction [Fructose promotes the reaction [Glucose binds to HBB protein]]; Pioglitazone inhibits the reaction [Fructose promotes the reaction [Glucose binds to HBB protein]] CTD PMID:25679220 NCBI chr 1:158,250,421...158,251,832 JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase multiple interactions
increases expression
EXP [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in decreased activity of SIRT1 protein] inhibits the reaction [Fructose results in increased expression of HMGCR mRNA]; [Niacinamide results in decreased activity of SIRT1 protein] inhibits the reaction [Fructose results in increased expression of HMGCR mRNA]; Rotenone inhibits the reaction [Fructose results in increased expression of HMGCR mRNA]; Tea inhibits the reaction [Fructose results in increased expression of HMGCR mRNA] CTD PMID:19193814 PMID:21212096 NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703
JBrowse link
G Hmgcs2 3-hydroxy-3-methylglutaryl-CoA synthase 2 multiple interactions EXP [Fructose co-treated with Copper deficiency] results in decreased expression of HMGCS2 mRNA; gadolinium chloride promotes the reaction [[Fructose co-treated with Copper deficiency] results in decreased expression of HMGCS2 mRNA] CTD PMID:25813056 NCBI chr 2:185,875,609...185,903,505
Ensembl chr 2:185,875,616...185,902,130
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression
EXP
ISO
[Atorvastatin co-treated with dapagliflozin] inhibits the reaction [[Fructose co-treated with Dietary Fats] results in decreased expression of HMOX1 protein]; [Curcumin co-treated with Fructose] results in increased expression of HMOX1 protein; [Fructose co-treated with Dietary Fats] results in decreased expression of HMOX1 protein; [Hemin co-treated with Fructose] results in increased expression of HMOX1 protein; Atorvastatin inhibits the reaction [[Fructose co-treated with Dietary Fats] results in decreased expression of HMOX1 protein]; caffeic acid phenethyl ester inhibits the reaction [Fructose results in increased expression of HMOX1 protein]; dapagliflozin inhibits the reaction [[Fructose co-treated with Dietary Fats] results in decreased expression of HMOX1 protein]
Fructose results in increased expression of HMOX1 mRNA
CTD PMID:24508943 PMID:25268984 PMID:28257781 PMID:31655124 PMID:32259528 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Hnf4a hepatocyte nuclear factor 4, alpha multiple interactions
decreases expression
ISO
EXP
Cerulenin inhibits the reaction [Fructose results in decreased expression of HNF4A mRNA]
Fructose results in decreased expression of HNF4A mRNA; Fructose results in decreased expression of HNF4A protein
Berberine inhibits the reaction [Fructose results in decreased expression of HNF4A mRNA]; Berberine inhibits the reaction [Fructose results in decreased expression of HNF4A protein]; rosiglitazone inhibits the reaction [Fructose results in decreased expression of HNF4A mRNA]
CTD PMID:17992261 PMID:18563319 PMID:19196556 NCBI chr 3:152,186,787...152,248,320
Ensembl chr 3:152,186,787...152,248,320
JBrowse link
G Hnrnpa2b1 heterogeneous nuclear ribonucleoprotein A2/B1 multiple interactions
decreases expression
EXP [Fructose co-treated with bisphenol A] results in increased expression of HNRNPA2B1 protein
Fructose results in decreased expression of HNRNPA2B1 protein
CTD PMID:26930160 NCBI chr 4:80,534,659...80,545,297
Ensembl chr 4:80,534,651...80,545,249
JBrowse link
G Hnrnpa3 heterogeneous nuclear ribonucleoprotein A3 multiple interactions EXP [Fructose co-treated with bisphenol A] results in increased expression of HNRNPA3 protein CTD PMID:26930160 NCBI chr 3:60,578,574...60,588,755
Ensembl chr 3:60,578,673...60,588,306
JBrowse link
G Hnrnpk heterogeneous nuclear ribonucleoprotein K multiple interactions EXP [Fructose co-treated with bisphenol A] results in increased expression of HNRNPK protein CTD PMID:26930160 NCBI chr17:6,262,936...6,275,001
Ensembl chr17:6,262,998...6,274,997
JBrowse link
G Hoxc9 homeobox C9 multiple interactions
decreases expression
EXP [Ozone co-treated with Fructose] results in decreased expression of HOXC9 mRNA; [Particulate Matter co-treated with Ozone co-treated with Fructose] results in decreased expression of HOXC9 mRNA; Fructose affects the reaction [Particulate Matter results in decreased expression of HOXC9 mRNA]
Fructose results in decreased expression of HOXC9 mRNA
CTD PMID:23968387 NCBI chr 7:134,118,817...134,121,497
Ensembl chr 7:134,118,817...134,121,492
JBrowse link
G Hprt1 hypoxanthine phosphoribosyltransferase 1 decreases expression ISO Fructose results in decreased expression of HPRT1 mRNA CTD PMID:31655124 NCBI chr  X:132,736,175...132,768,149
Ensembl chr  X:132,736,096...132,768,154
JBrowse link
G Hspa1b heat shock protein family A (Hsp70) member 1B increases expression EXP Fructose results in increased expression of HSPA1B mRNA CTD PMID:15150374 NCBI chr20:3,855,104...3,859,148
Ensembl chr20:3,856,006...3,873,240
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression
multiple interactions
ISO Fructose results in increased expression of HSPA5 mRNA; Fructose results in increased expression of HSPA5 protein
Phenylbutyrates inhibits the reaction [Fructose results in increased expression of HSPA5 protein]
CTD PMID:22698815 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
JBrowse link
G Hspd1 heat shock protein family D (Hsp60) member 1 multiple interactions
increases expression
EXP Amlodipine inhibits the reaction [Fructose results in increased expression of HSPD1 protein]; rosiglitazone inhibits the reaction [Fructose results in increased expression of HSPD1 protein] CTD PMID:18948349 PMID:26930160 NCBI chr 9:56,579,195...56,590,011
Ensembl chr 9:56,579,201...56,589,662
JBrowse link
G Hspe1 heat shock protein family E (Hsp10) member 1 multiple interactions EXP [Fructose co-treated with bisphenol A] results in increased expression of HSPE1 protein CTD PMID:26930160 NCBI chr 9:56,589,912...56,593,000
Ensembl chr 9:56,589,789...56,593,089
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions
increases expression
ISO
EXP
2,2'-(hydroxynitrosohydrazono)bis-ethanamine inhibits the reaction [Fructose results in increased expression of ICAM1 protein]; Adenosine Triphosphate inhibits the reaction [Fructose results in increased expression of ICAM1 protein]
Metformin inhibits the reaction [Fructose results in increased expression of ICAM1 protein modified form]; resveratrol inhibits the reaction [Fructose results in increased expression of ICAM1 protein modified form]
Fructose results in increased expression of ICAM1 mRNA; Fructose results in increased expression of ICAM1 protein
CTD PMID:18508964 PMID:25108154 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
JBrowse link
G Idh3b isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit beta decreases expression EXP Fructose results in decreased expression of IDH3B protein CTD PMID:26930160 NCBI chr 3:117,481,845...117,486,909
Ensembl chr 3:117,481,845...117,486,982
JBrowse link
G Igfbp3 insulin-like growth factor binding protein 3 multiple interactions EXP [Fructose co-treated with Ozone co-treated with Particulate Matter] results in decreased expression of IGFBP3 mRNA; [Fructose co-treated with Ozone] results in decreased expression of IGFBP3 mRNA; [Particulate Matter co-treated with Fructose] results in decreased expression of IGFBP3 mRNA; Fructose affects the reaction [Particulate Matter results in decreased expression of IGFBP3 mRNA] CTD PMID:23968387 NCBI chr14:82,056,347...82,064,083
Ensembl chr14:82,056,347...82,064,083
JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta increases phosphorylation
multiple interactions
EXP Fructose results in increased phosphorylation of IKBKB protein
Allopurinol inhibits the reaction [Fructose results in increased phosphorylation of IKBKB protein]; Quercetin inhibits the reaction [Fructose results in increased phosphorylation of IKBKB protein]
CTD PMID:24491314 NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250
JBrowse link
G Il10 interleukin 10 multiple interactions
decreases expression
EXP [Fructose co-treated with Ozone co-treated with Particulate Matter] results in decreased expression of IL10 mRNA; Fructose affects the reaction [Ozone results in decreased expression of IL10 mRNA]; Fructose affects the reaction [Particulate Matter results in decreased expression of IL10 mRNA]
Fructose results in decreased expression of IL10 mRNA
CTD PMID:23968387 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il18 interleukin 18 multiple interactions
increases expression
EXP Allopurinol inhibits the reaction [Fructose results in increased expression of IL18 protein]; Felodipine inhibits the reaction [Fructose results in increased expression of IL18 mRNA]; Felodipine inhibits the reaction [Fructose results in increased expression of IL18 protein]; Quercetin inhibits the reaction [Fructose results in increased expression of IL18 protein]; Rutin inhibits the reaction [Fructose results in increased expression of IL18 protein]
Fructose results in increased expression of IL18 mRNA; Fructose results in increased expression of IL18 protein
CTD PMID:18504504 PMID:22426011 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
JBrowse link
G Il1b interleukin 1 beta increases expression
increases secretion
multiple interactions
EXP
ISO
Fructose results in increased expression of IL1B protein
Fructose results in increased secretion of IL1B protein
[Fructose co-treated with Ethanol] results in increased expression of IL1B mRNA
[gadolinium chloride co-treated with Fructose co-treated with Copper deficiency] results in decreased expression of IL1B mRNA; Allopurinol inhibits the reaction [Fructose results in increased expression of IL1B protein]; geraniol inhibits the reaction [Fructose results in increased expression of IL1B protein]; geraniol inhibits the reaction [Fructose results in increased secretion of IL1B protein]; Pioglitazone inhibits the reaction [Fructose results in increased secretion of IL1B protein]; PTMA protein inhibits the reaction [Fructose results in increased expression of IL1B protein]; Quercetin inhibits the reaction [Fructose results in increased expression of IL1B protein]; Rutin inhibits the reaction [Fructose results in increased expression of IL1B protein]; tributylhexadecylphosphonium bromide inhibits the reaction [Fructose results in increased expression of IL1B protein]
CTD PMID:15885234 PMID:22426011 PMID:24491314 PMID:25679220 PMID:25813056 More... NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il2 interleukin 2 increases expression EXP Fructose results in increased expression of IL2 protein CTD PMID:15885234 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
JBrowse link
G Il6 interleukin 6 multiple interactions
increases expression
EXP
ISO
[gadolinium chloride co-treated with Fructose co-treated with Copper deficiency] results in decreased expression of IL6 mRNA; Allopurinol inhibits the reaction [Fructose results in increased expression of IL6 protein]; galangin inhibits the reaction [Fructose results in increased expression of IL6 protein]; Genistein inhibits the reaction [Fructose results in increased expression of IL6 protein]; geraniol inhibits the reaction [Fructose results in increased expression of IL6 protein]; Metformin inhibits the reaction [Fructose results in increased expression of IL6 protein]; PTMA protein inhibits the reaction [Fructose results in increased expression of IL6 protein]; Quercetin inhibits the reaction [Fructose results in increased expression of IL6 protein]; Resveratrol inhibits the reaction [Fructose results in increased expression of IL6 protein]; Rutin inhibits the reaction [Fructose results in increased expression of IL6 protein]; tributylhexadecylphosphonium bromide inhibits the reaction [Fructose results in increased expression of IL6 protein] CTD PMID:15885234 PMID:21704028 PMID:21708140 PMID:22426011 PMID:25108154 More... NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Ins2 insulin 2 decreases response to substance
increases secretion
increases expression
multiple interactions
ISO
EXP
Fructose results in decreased susceptibility to INS protein
Fructose results in increased secretion of INS protein
Fructose results in increased expression of INS protein; Fructose results in increased expression of INS2 mRNA
Curcumin inhibits the reaction [Fructose results in increased expression of INS protein]; Hemin inhibits the reaction [Fructose results in increased expression of INS protein]; INS protein inhibits the reaction [Fructose results in increased expression of AGTR1A mRNA]; Quercetin inhibits the reaction [Fructose results in increased expression of INS2 mRNA]
CTD PMID:12010179 PMID:18360027 PMID:23533474 PMID:25268984 PMID:26713546 NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775
JBrowse link
G Insig1 insulin induced gene 1 decreases expression
increases expression
multiple interactions
ISO Fructose results in decreased expression of INSIG1 protein
Fructose results in increased expression of INSIG1 mRNA
Phenylbutyrates inhibits the reaction [Fructose results in decreased expression of INSIG1 protein]
CTD PMID:22698815 NCBI chr 4:7,315,494...7,323,972
Ensembl chr 4:7,315,495...7,323,952
JBrowse link
G Insig2 insulin induced gene 2 increases expression ISO Fructose results in increased expression of INSIG2 mRNA CTD PMID:22698815 NCBI chr13:32,472,390...32,500,139
Ensembl chr13:32,473,742...32,494,923
JBrowse link
G Insr insulin receptor decreases expression
decreases phosphorylation
multiple interactions
EXP Fructose results in decreased expression of INSR mRNA; Fructose results in decreased expression of INSR protein
Fructose results in decreased phosphorylation of INSR protein
[Fructose co-treated with Oleanolic Acid] results in increased expression of INSR mRNA; [Fructose co-treated with Sodium Chloride, Dietary deficiency] results in decreased expression of INSR mRNA; [Fructose co-treated with Sodium Chloride, Dietary deficiency] results in decreased expression of INSR protein; Allopurinol inhibits the reaction [Fructose results in decreased phosphorylation of INSR protein]; Quercetin inhibits the reaction [Fructose results in decreased phosphorylation of INSR protein]; Rutin inhibits the reaction [Fructose results in decreased phosphorylation of INSR protein]
CTD PMID:14573337 PMID:14633139 PMID:22426011 PMID:24491314 PMID:24704288 NCBI chr12:1,193,193...1,330,976
Ensembl chr12:1,197,100...1,330,883
JBrowse link
G Irf3 interferon regulatory factor 3 multiple interactions ISO [Fructose co-treated with Ethanol] results in increased expression of IRF3 protein; Fructose promotes the reaction [Ethanol results in increased expression of IRF3 mRNA] CTD PMID:26858005 NCBI chr 1:95,479,966...95,484,926
Ensembl chr 1:95,479,821...95,484,935
JBrowse link
G Irf7 interferon regulatory factor 7 multiple interactions
increases expression
ISO [Fructose co-treated with Ethanol] results in increased expression of IRF7 protein
Fructose results in increased expression of IRF7 protein
CTD PMID:26858005 NCBI chr 1:196,367,380...196,370,943
Ensembl chr 1:196,367,361...196,370,832
JBrowse link
G Irs1 insulin receptor substrate 1 decreases expression
increases phosphorylation
decreases phosphorylation
multiple interactions
affects phosphorylation
EXP
ISO
Fructose results in decreased expression of IRS1 mRNA; Fructose results in decreased expression of IRS1 protein
Fructose results in increased phosphorylation of IRS1 protein
Fructose results in decreased phosphorylation of IRS1 protein
[Fructose co-treated with Oleanolic Acid] results in increased expression of IRS1 mRNA; [Fructose co-treated with Oleanolic Acid] results in increased expression of IRS1 protein; [Fructose co-treated with resveratrol] results in increased expression of IRS1 mRNA; Allopurinol inhibits the reaction [Fructose results in decreased phosphorylation of IRS1 protein]; Curcumin inhibits the reaction [Fructose affects the phosphorylation of IRS1 protein]; NOS3 protein inhibits the reaction [Fructose results in decreased expression of IRS1 protein]; Oleanolic Acid inhibits the reaction [Fructose results in increased phosphorylation of IRS1 protein]; Quercetin inhibits the reaction [Fructose results in decreased phosphorylation of IRS1 protein]; Rutin inhibits the reaction [Fructose results in decreased phosphorylation of IRS1 protein]
CTD PMID:19008412 PMID:19165636 PMID:22426011 PMID:24704288 PMID:26488877 More... NCBI chr 9:83,552,964...83,605,797
Ensembl chr 9:83,548,944...83,606,122
JBrowse link
G Irs2 insulin receptor substrate 2 decreases expression
multiple interactions
EXP Fructose results in decreased expression of IRS2 mRNA; Fructose results in decreased expression of IRS2 protein
NOS3 protein inhibits the reaction [Fructose results in decreased expression of IRS2 protein]; resveratrol inhibits the reaction [Fructose results in decreased expression of IRS2 mRNA]
CTD PMID:19008412 PMID:19165636 PMID:26488877 NCBI chr16:78,488,249...78,512,482
Ensembl chr16:78,485,045...78,512,482
JBrowse link
G Itgb1 integrin subunit beta 1 decreases expression ISO Fructose results in decreased expression of ITGB1 mRNA CTD PMID:31655124 NCBI chr19:56,705,123...56,753,199
Ensembl chr19:56,705,171...56,753,195
JBrowse link
G Itih3 inter-alpha trypsin inhibitor, heavy chain 3 decreases expression EXP Fructose results in decreased expression of ITIH3 protein CTD PMID:26930160 NCBI chr16:6,101,922...6,117,154
Ensembl chr16:6,101,930...6,116,924
JBrowse link
G Jak2 Janus kinase 2 decreases phosphorylation
multiple interactions
EXP Fructose results in decreased phosphorylation of JAK2 protein
Quercetin inhibits the reaction [Fructose results in decreased phosphorylation of JAK2 protein]; Rutin inhibits the reaction [Fructose results in decreased phosphorylation of JAK2 protein]
CTD PMID:22426011 NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression
EXP Dactinomycin inhibits the reaction [Fructose results in increased expression of JUN mRNA] CTD PMID:11123204 PMID:11557636 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
JBrowse link
G Jup junction plakoglobin multiple interactions EXP [Fructose co-treated with bisphenol A] results in increased expression of JUP protein CTD PMID:26930160 NCBI chr10:85,300,438...85,327,378
Ensembl chr10:85,300,440...85,327,057
JBrowse link
G Kdr kinase insert domain receptor multiple interactions EXP [bisphenol A co-treated with Fructose] results in increased expression of KDR mRNA CTD PMID:27622962 NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018
JBrowse link
G Khk ketohexokinase multiple interactions
increases expression
ISO
EXP
KHK protein promotes the reaction [Fructose results in decreased abundance of Adenosine Triphosphate]; KHK protein promotes the reaction [Fructose results in increased abundance of Reactive Oxygen Species]; KHK protein promotes the reaction [Fructose results in increased secretion of CCL2 protein]
Atorvastatin inhibits the reaction [Fructose results in increased expression of KHK protein]
Fructose results in increased expression of KHK mRNA; Fructose results in increased expression of KHK protein
FGF21 gene mutant form inhibits the reaction [Fructose results in increased expression of KHK mRNA]; Fructose results in increased expression of and results in increased activity of KHK protein
CTD PMID:15066988 PMID:18346472 PMID:18395287 PMID:19158351 PMID:21122807 More... NCBI chr 6:25,445,298...25,455,834
Ensembl chr 6:25,445,300...25,455,717
JBrowse link
G Klk1 kallikrein 1 multiple interactions EXP KLK1 protein inhibits the reaction [Fructose results in increased expression of AGTR1B mRNA]; KLK1 protein inhibits the reaction [Fructose results in increased expression of EDN1 mRNA]; KLK1 protein inhibits the reaction [Fructose results in increased expression of EDNRA mRNA] CTD PMID:14568997 NCBI chr 1:94,642,722...94,646,714
Ensembl chr 1:94,642,687...94,646,754
JBrowse link
G Kng2 kininogen 2 decreases expression EXP Fructose results in decreased expression of MAP1 protein CTD PMID:26930160 NCBI chr11:77,913,876...77,936,247 JBrowse link
G Krt18 keratin 18 increases expression EXP Fructose increases expression of Krt18 protein in liver and serum RGD PMID:29989845 RGD:26884460 NCBI chr 7:133,157,486...133,161,162
Ensembl chr 7:133,157,475...133,161,166
JBrowse link
G Lcn2 lipocalin 2 multiple interactions EXP [dapagliflozin co-treated with Atorvastatin] inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of LCN2 protein]; [Fructose co-treated with Dietary Fats] results in increased expression of LCN2 protein; [Streptozocin co-treated with Fructose] results in increased expression of LCN2 protein; Atorvastatin inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of LCN2 protein]; dapagliflozin inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of LCN2 protein]; dapagliflozin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of LCN2 protein]; Metformin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of LCN2 protein] CTD PMID:30551545 PMID:32259528 NCBI chr 3:15,680,688...15,684,033
Ensembl chr 3:15,680,687...15,684,095
JBrowse link
G Lct lactase increases expression EXP Fructose results in increased expression of LCT mRNA CTD PMID:11242478 NCBI chr13:39,781,929...39,824,456
Ensembl chr13:39,781,929...39,824,456
JBrowse link
G Ldhb lactate dehydrogenase B multiple interactions EXP [Fructose co-treated with bisphenol A] results in decreased expression of LDHB protein CTD PMID:26930160 NCBI chr 4:175,428,382...175,446,403
Ensembl chr 4:175,428,385...175,446,403
JBrowse link
G Lep leptin increases secretion
increases expression
multiple interactions
EXP Fructose results in increased secretion of LEP protein
Fructose results in increased expression of LEP mRNA; Fructose results in increased expression of LEP protein
[Fenofibrate co-treated with Resveratrol] inhibits the reaction [Fructose results in increased expression of LEP mRNA]; [Ozone co-treated with Fructose] results in increased expression of LEP mRNA; [Particulate Matter co-treated with Fructose] results in increased expression of LEP mRNA; [Particulate Matter co-treated with Ozone co-treated with Fructose] results in increased expression of LEP mRNA; Allopurinol inhibits the reaction [Fructose results in increased expression of LEP protein]; Atorvastatin affects the reaction [Fructose results in increased expression of LEP protein]; Fenofibrate inhibits the reaction [Fructose results in increased expression of LEP mRNA]; Quercetin inhibits the reaction [Fructose results in increased expression of LEP protein]; Quercetin inhibits the reaction [Fructose results in increased secretion of LEP protein]; Resveratrol inhibits the reaction [Fructose results in increased expression of LEP mRNA]; Rutin inhibits the reaction [Fructose results in increased expression of LEP protein]
CTD PMID:10780946 PMID:11741341 PMID:18627777 PMID:19165636 PMID:21122807 More... NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262
JBrowse link
G Lepr leptin receptor multiple interactions EXP Allopurinol inhibits the reaction [Fructose results in increased expression of and results in increased phosphorylation of LEPR protein]; Fructose results in increased expression of and results in increased phosphorylation of LEPR protein; Quercetin inhibits the reaction [Fructose results in increased expression of and results in increased phosphorylation of LEPR protein]; Rutin inhibits the reaction [Fructose results in increased expression of and results in increased phosphorylation of LEPR protein] CTD PMID:22426011 NCBI chr 5:116,294,409...116,477,904
Ensembl chr 5:116,289,823...116,475,908
JBrowse link
G Lgals9 galectin 9 multiple interactions
decreases expression
EXP Allopurinol inhibits the reaction [Fructose results in decreased expression of LGALS9 mRNA]; Allopurinol inhibits the reaction [Fructose results in decreased expression of LGALS9 protein]; Quercetin inhibits the reaction [Fructose results in decreased expression of LGALS9 mRNA]; Quercetin inhibits the reaction [Fructose results in decreased expression of LGALS9 protein]; Rutin inhibits the reaction [Fructose results in decreased expression of LGALS9 mRNA]; Rutin inhibits the reaction [Fructose results in decreased expression of LGALS9 protein]
Fructose results in decreased expression of LGALS9 mRNA; Fructose results in decreased expression of LGALS9 protein
CTD PMID:19605544 NCBI chr10:63,907,018...63,930,224
Ensembl chr10:63,907,018...63,930,045
JBrowse link
G Maoa monoamine oxidase A multiple interactions EXP [Fructose co-treated with bisphenol A] results in increased expression of MAOA protein CTD PMID:26930160 NCBI chr  X:6,032,172...6,098,308
Ensembl chr  X:6,030,795...6,099,593
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation
decreases phosphorylation
multiple interactions
EXP Fructose results in increased phosphorylation of MAPK1 protein
Fructose results in decreased phosphorylation of MAPK1 protein
Curcumin inhibits the reaction [Fructose results in increased phosphorylation of MAPK1 protein]; Quercetin inhibits the reaction [Fructose results in decreased phosphorylation of MAPK1 protein]; Rutin inhibits the reaction [Fructose results in decreased phosphorylation of MAPK1 protein]
CTD PMID:22426011 PMID:26713546 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation
decreases phosphorylation
multiple interactions
EXP Fructose results in increased phosphorylation of MAPK3 protein
Fructose results in decreased phosphorylation of MAPK3 protein
Curcumin inhibits the reaction [Fructose results in increased phosphorylation of MAPK3 protein]; Quercetin inhibits the reaction [Fructose results in decreased phosphorylation of MAPK3 protein]; Rutin inhibits the reaction [Fructose results in decreased phosphorylation of MAPK3 protein]
CTD PMID:22426011 PMID:26713546 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions
increases expression
EXP imoxin inhibits the reaction [Fructose results in increased expression of MAPK8 protein] CTD PMID:29430716 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
JBrowse link
G Mfn2 mitofusin 2 multiple interactions ISO [Fructose co-treated with Palmitic Acid] results in decreased expression of MFN2 protein; Fenofibrate inhibits the reaction [[Fructose co-treated with Palmitic Acid] results in decreased expression of MFN2 protein] CTD PMID:32730863 NCBI chr 5:158,304,285...158,335,502
Ensembl chr 5:158,304,287...158,335,342
JBrowse link
G Mir33 microRNA 33 multiple interactions EXP [Fructose co-treated with Streptozocin] results in increased expression of MIR33A mRNA; Ghrelin inhibits the reaction [[Fructose co-treated with Streptozocin] results in increased expression of MIR33A mRNA] CTD PMID:31468622 NCBI chr 7:113,713,855...113,713,923
Ensembl chr 7:113,713,855...113,713,923
JBrowse link
G Mlx MAX dimerization protein MLX increases expression EXP Fructose results in increased expression of MLX mRNA CTD PMID:18346472 NCBI chr10:86,019,216...86,024,326
Ensembl chr10:86,019,588...86,032,350
JBrowse link
G Mlxipl MLX interacting protein-like multiple interactions
decreases expression
increases expression
increases activity
EXP
ISO
Atorvastatin inhibits the reaction [Fructose affects the localization of and results in increased activity of MLXIPL protein]; Atorvastatin inhibits the reaction [Fructose results in increased expression of MLXIPL protein]; Fructose affects the localization of and results in increased activity of MLXIPL protein; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Atorvastatin inhibits the reaction [Fructose results in increased activity of MLXIPL protein]]
Fructose results in decreased expression of MLXIPL mRNA
Fructose results in increased expression of MLXIPL mRNA alternative form
FGF21 gene mutant form inhibits the reaction [Fructose results in increased expression of MLXIPL mRNA alternative form]; MLXIPL gene mutant form inhibits the reaction [Fructose results in increased expression of FGF21 mRNA]; MLXIPL gene mutant form inhibits the reaction [Fructose results in increased secretion of FGF21 protein]
Fructose results in increased expression of MLXIPL mRNA; Fructose results in increased expression of MLXIPL protein
CTD PMID:18346472 PMID:19053045 PMID:19799862 PMID:21122807 PMID:28123933 NCBI chr12:21,542,964...21,577,120
Ensembl chr12:21,543,576...21,577,112
JBrowse link
G Mlycd malonyl-CoA decarboxylase multiple interactions
decreases expression
EXP [Fenofibrate co-treated with resveratrol] inhibits the reaction [Fructose results in decreased expression of MLYCD mRNA]; Fenofibrate inhibits the reaction [Fructose results in decreased expression of MLYCD mRNA]; resveratrol inhibits the reaction [Fructose results in decreased expression of MLYCD mRNA] CTD PMID:26973390 NCBI chr19:47,447,931...47,463,794
Ensembl chr19:47,447,970...47,463,793
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions ISO [FGF21 gene mutant form results in increased susceptibility to Fructose] which results in increased expression of MMP2 mRNA CTD PMID:28123933 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
JBrowse link
G Mmp9 matrix metallopeptidase 9 increases expression ISO Fructose results in increased expression of MMP9 mRNA CTD PMID:31655124 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Mpst mercaptopyruvate sulfurtransferase multiple interactions EXP [Fructose co-treated with bisphenol A] results in decreased expression of MPST protein CTD PMID:26930160 NCBI chr 7:109,955,581...109,963,155
Ensembl chr 7:109,955,675...109,963,141
JBrowse link
G Msn moesin multiple interactions EXP [Fructose co-treated with bisphenol A] results in increased expression of MSN protein CTD PMID:26930160 NCBI chr  X:60,996,043...61,064,011
Ensembl chr  X:60,995,951...61,065,628
JBrowse link
G Mt-atp6 mitochondrially encoded ATP synthase membrane subunit 6 increases expression EXP Fructose results in increased expression of ATP6 protein CTD PMID:11934685 NCBI chr MT:7,919...8,599
Ensembl chr MT:7,919...8,599
JBrowse link
G Mt-co2 mitochondrially encoded cytochrome c oxidase II multiple interactions EXP [Fructose co-treated with bisphenol A] results in decreased expression of COX2 protein CTD PMID:26930160 NCBI chr MT:7,006...7,689
Ensembl chr MT:7,006...7,689
JBrowse link
G Mt1-ps2 metallothionein 1, pseudogene 2 multiple interactions
increases expression
EXP Atorvastatin inhibits the reaction [Fructose results in increased expression of MT1-PS2 mRNA] CTD PMID:21122807
G Mt2A metallothionein 2A increases expression
multiple interactions
EXP Fructose results in increased expression of MT2A mRNA
Atorvastatin inhibits the reaction [Fructose results in increased expression of MT2A mRNA]
CTD PMID:21122807 NCBI chr19:10,832,009...10,832,783
Ensembl chr19:10,832,002...10,832,784
JBrowse link
G Mttp microsomal triglyceride transfer protein multiple interactions
increases expression
EXP
ISO
[Fructose co-treated with Copper deficiency] results in decreased expression of MTTP mRNA
FGF21 gene mutant form inhibits the reaction [Fructose results in increased expression of MTTP mRNA]
CTD PMID:25813056 PMID:28123933 NCBI chr 2:226,613,090...226,654,239
Ensembl chr 2:226,613,090...226,654,239
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor decreases expression ISO Fructose results in decreased expression of MYC mRNA CTD PMID:2558650 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
JBrowse link
G Myd88 MYD88, innate immune signal transduction adaptor multiple interactions ISO Fructose promotes the reaction [Ethanol results in increased expression of MYD88 mRNA] CTD PMID:26858005 NCBI chr 8:119,074,439...119,078,508
Ensembl chr 8:119,074,437...119,079,415
JBrowse link
G Myh6 myosin heavy chain 6 increases expression
multiple interactions
ISO Fructose results in increased expression of MYH6 mRNA
SIRT1 protein affects the reaction [Fructose results in increased expression of MYH6 mRNA]
CTD PMID:18192211 NCBI chr15:28,418,120...28,442,316
Ensembl chr15:28,417,616...28,441,720
JBrowse link
G Myh9 myosin, heavy chain 9 decreases expression
multiple interactions
EXP Fructose results in decreased expression of MYH9 protein
[Fructose co-treated with bisphenol A] results in increased expression of MYH9 protein
CTD PMID:26930160 NCBI chr 7:109,343,718...109,424,457
Ensembl chr 7:109,343,706...109,424,457
JBrowse link
G Ndufa5 NADH:ubiquinone oxidoreductase subunit A5 multiple interactions EXP [Fructose co-treated with bisphenol A] results in increased expression of NDUFA5 protein CTD PMID:26930160 NCBI chr 4:52,997,327...53,005,685
Ensembl chr 4:52,995,546...53,005,598
JBrowse link
G Ndufa9 NADH:ubiquinone oxidoreductase subunit A9 multiple interactions EXP [Fructose co-treated with bisphenol A] results in decreased expression of NDUFA9 protein CTD PMID:26930160 NCBI chr 4:159,659,242...159,688,034
Ensembl chr 4:159,659,242...159,688,018
JBrowse link
G Nfatc4 nuclear factor of activated T-cells 4 increases expression
multiple interactions
EXP Fructose results in increased expression of NFATC4 protein
tributylhexadecylphosphonium bromide inhibits the reaction [Fructose results in increased expression of NFATC4 protein]
CTD PMID:26358169 NCBI chr15:29,286,998...29,314,610
Ensembl chr15:29,305,535...29,314,610
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 increases expression
multiple interactions
ISO
EXP
Fructose results in increased expression of NFE2L2 protein
[Fructose co-treated with Palmitic Acid] results in decreased expression of NFE2L2 protein; Fenofibrate inhibits the reaction [[Fructose co-treated with Palmitic Acid] results in decreased expression of NFE2L2 protein]
[Atorvastatin co-treated with dapagliflozin] inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of NFE2L2 protein]; [Fructose co-treated with Dietary Fats] results in increased expression of NFE2L2 protein; Atorvastatin inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of NFE2L2 protein]; dapagliflozin inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of NFE2L2 protein]
Fructose promotes the reaction [PPARD gene mutant form results in increased phosphorylation of NFE2L2 protein]; Plant Preparations inhibits the reaction [Fructose results in increased expression of NFE2L2 protein]
CTD PMID:27531227 PMID:29289645 PMID:32259528 PMID:32730863 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nfkbia NFKB inhibitor alpha increases degradation
increases phosphorylation
multiple interactions
EXP Fructose results in increased degradation of NFKBIA protein
Fructose results in increased phosphorylation of NFKBIA protein
Allopurinol inhibits the reaction [Fructose results in increased phosphorylation of NFKBIA protein]; Curcumin inhibits the reaction [Fructose results in increased degradation of NFKBIA protein]; Quercetin inhibits the reaction [Fructose results in increased phosphorylation of NFKBIA protein]
CTD PMID:24491314 PMID:26713546 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Ngf nerve growth factor decreases expression EXP Fructose results in decreased expression of NGF mRNA; Fructose results in decreased expression of NGF protein CTD PMID:18585860 NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452
JBrowse link
G Ngfr nerve growth factor receptor decreases expression EXP Fructose results in decreased expression of NGFR mRNA CTD PMID:18585860 NCBI chr10:80,515,287...80,533,518
Ensembl chr10:80,515,299...80,533,518
JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 increases expression
multiple interactions
EXP Fructose results in increased expression of NLRP3 protein
Allopurinol inhibits the reaction [Fructose results in increased expression of NLRP3 protein]; Quercetin inhibits the reaction [Fructose results in increased expression of NLRP3 protein]; Rutin inhibits the reaction [Fructose results in increased expression of NLRP3 protein]
CTD PMID:22426011 PMID:24491314 NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
increases expression
EXP
ISO
2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [caryophyllene inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of NOS2 protein]]; [Dietary Fats co-treated with Fructose] results in increased expression of NOS2 protein; [Fructose results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide; caryophyllene inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of NOS2 protein]; iodopravadoline inhibits the reaction [caryophyllene inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of NOS2 protein]]; Pioglitazone inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of NOS2 protein]; Resveratrol inhibits the reaction [Fructose results in increased expression of NOS2 mRNA]; Resveratrol inhibits the reaction [Fructose results in increased expression of NOS2 protein]
Fructose results in increased expression of NOS2 mRNA; Fructose results in increased expression of NOS2 protein
CTD PMID:10090849 PMID:26488877 PMID:28257781 PMID:30343038 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions
decreases expression
decreases phosphorylation
decreases activity
EXP
ISO
2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [caryophyllene inhibits the reaction [[Dietary Fats co-treated with Fructose] results in decreased expression of NOS3 protein]]; [bisphenol A co-treated with Fructose] results in increased expression of NOS3 mRNA; [Dietary Fats co-treated with Fructose] results in decreased expression of NOS3 protein; [Resveratrol co-treated with Fructose] results in increased expression of NOS3 mRNA; caryophyllene inhibits the reaction [[Dietary Fats co-treated with Fructose] results in decreased expression of NOS3 protein]; Fish Oils inhibits the reaction [Fructose results in decreased expression of NOS3 mRNA]; Fish Oils inhibits the reaction [Fructose results in decreased expression of NOS3 protein]; iodopravadoline inhibits the reaction [caryophyllene inhibits the reaction [[Dietary Fats co-treated with Fructose] results in decreased expression of NOS3 protein]]; Metformin inhibits the reaction [Fructose results in decreased phosphorylation of NOS3 protein]; NOS3 protein inhibits the reaction [Fructose results in decreased expression of IRS1 protein]; NOS3 protein inhibits the reaction [Fructose results in decreased expression of IRS2 protein]; NOS3 protein inhibits the reaction [Fructose results in decreased phosphorylation of AKT1 protein]; Pioglitazone inhibits the reaction [[Dietary Fats co-treated with Fructose] results in decreased expression of NOS3 protein]; Resveratrol inhibits the reaction [Fructose results in decreased expression of NOS3 mRNA]; Resveratrol inhibits the reaction [Fructose results in decreased expression of NOS3 protein]; Resveratrol inhibits the reaction [Fructose results in decreased phosphorylation of NOS3 protein]
Fructose results in decreased expression of NOS3 mRNA; Fructose results in decreased expression of NOS3 protein
Fructose results in decreased activity of NOS3 protein
CTD PMID:10580434 PMID:15752949 PMID:18508964 PMID:19008412 PMID:25108154 More... NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
JBrowse link
G Nox4 NADPH oxidase 4 increases expression EXP Fructose results in increased expression of NOX4 mRNA CTD PMID:17587757 NCBI chr 1:140,900,886...141,078,844
Ensembl chr 1:140,901,097...141,077,406
JBrowse link
G Npy neuropeptide Y decreases expression EXP Fructose results in decreased expression of NPY mRNA CTD PMID:18627777 NCBI chr 4:78,881,294...78,888,495
Ensembl chr 4:78,881,264...78,888,495
JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 multiple interactions ISO NR0B2 protein inhibits the reaction [AHR protein results in increased susceptibility to [Dietary Fats co-treated with Fructose]]; NR0B2 protein results in decreased susceptibility to [Dietary Fats co-treated with Fructose] CTD PMID:29416063 NCBI chr 5:145,779,294...145,782,609
Ensembl chr 5:145,779,294...145,782,609
JBrowse link
G Nr2f1 nuclear receptor subfamily 2, group F, member 1 multiple interactions ISO Fructose affects the reaction [NR2F1 protein binds to SHBG promoter] CTD PMID:17992261 NCBI chr 2:8,040,375...8,050,123
Ensembl chr 2:8,040,377...8,050,123
JBrowse link
G Oat ornithine aminotransferase multiple interactions EXP Fructose inhibits the reaction [Cyclic AMP results in increased activity of OAT protein]; Fructose inhibits the reaction [Cyclic AMP results in increased expression of OAT mRNA] CTD PMID:2827574 NCBI chr 1:187,347,862...187,367,644
Ensembl chr 1:187,347,865...187,367,682
JBrowse link
G Oga O-GlcNAcase multiple interactions EXP [Streptozocin co-treated with Fructose] results in increased expression of and results in increased secretion of OGA protein; dapagliflozin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of and results in increased secretion of OGA protein]; Metformin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of and results in increased secretion of OGA protein] CTD PMID:30551545 NCBI chr 1:244,598,285...244,633,835
Ensembl chr 1:244,598,292...244,634,359
JBrowse link
G Opa1 OPA1, mitochondrial dynamin like GTPase multiple interactions ISO [Fructose co-treated with Palmitic Acid] results in decreased expression of OPA1 protein; Fenofibrate inhibits the reaction [[Fructose co-treated with Palmitic Acid] results in decreased expression of OPA1 protein] CTD PMID:32730863 NCBI chr11:71,108,100...71,185,170
Ensembl chr11:71,109,873...71,185,109
JBrowse link
G Paip2 poly(A) binding protein interacting protein 2 multiple interactions ISO Fructose promotes the reaction [PAIP2 protein binds to SLC2A5 3' UTR] CTD PMID:12820898 NCBI chr18:27,199,762...27,218,359
Ensembl chr18:27,199,796...27,214,863
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases expression ISO Fructose results in increased expression of PARP1 protein CTD PMID:28257781 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1 multiple interactions
increases expression
increases activity
EXP Rosiglitazone inhibits the reaction [Fructose results in increased expression of PCK1 mRNA]; Rosiglitazone inhibits the reaction [Fructose results in increased expression of PCK1 protein]
Fructose results in increased expression of PCK1 mRNA; Fructose results in increased expression of PCK1 protein
Fructose results in increased activity of PCK1 protein
CTD PMID:19196556 PMID:21212096 NCBI chr 3:161,930,256...161,936,205
Ensembl chr 3:161,930,256...161,936,191
JBrowse link
G Pcmt1 protein-L-isoaspartate (D-aspartate) O-methyltransferase 1 multiple interactions EXP [Fructose co-treated with bisphenol A] results in increased expression of PCMT1 protein CTD PMID:26930160 NCBI chr 1:2,111,756...2,160,354
Ensembl chr 1:2,111,763...2,159,201
JBrowse link
G Pdk1 pyruvate dehydrogenase kinase 1 multiple interactions EXP [Fructose co-treated with bisphenol A] results in increased expression of PDK1 protein CTD PMID:26930160 NCBI chr 3:56,705,824...56,733,040
Ensembl chr 3:56,705,871...56,733,038
JBrowse link
G Pdx1 pancreatic and duodenal homeobox 1 multiple interactions
increases expression
EXP Quercetin inhibits the reaction [Fructose results in increased expression of PDX1 protein]
Fructose results in increased expression of PDX1 mRNA; Fructose results in increased expression of PDX1 protein
CTD PMID:23533474 NCBI chr12:7,757,865...7,763,064
Ensembl chr12:7,757,865...7,763,064
JBrowse link
G Pemt phosphatidylethanolamine N-methyltransferase multiple interactions ISO [Dietary Fats co-treated with Fructose] results in increased expression of PEMT mRNA; PEMT protein promotes the reaction [AHR protein results in increased susceptibility to [Dietary Fats co-treated with Fructose]] CTD PMID:29416063 NCBI chr10:44,775,910...44,849,990
Ensembl chr10:44,775,911...44,850,013
JBrowse link
G Pf4 platelet factor 4 increases expression ISO Fructose results in increased expression of PF4 mRNA CTD PMID:31655124 NCBI chr14:17,298,438...17,299,148
Ensembl chr14:17,298,308...17,299,365
JBrowse link
G Pfkl phosphofructokinase, liver type increases expression EXP Fructose results in increased expression of PFKL mRNA CTD PMID:18346472 NCBI chr20:10,664,285...10,686,324
Ensembl chr20:10,664,272...10,686,315
JBrowse link
G Phb2 prohibitin 2 multiple interactions EXP [Fructose co-treated with bisphenol A] results in decreased expression of PHB2 protein CTD PMID:26930160 NCBI chr 4:157,517,662...157,522,268
Ensembl chr 4:157,517,577...157,522,272
JBrowse link
G Pik3c2g phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma multiple interactions EXP [Fructose co-treated with Oleanolic Acid] results in increased expression of PIK3C2G mRNA CTD PMID:24704288 NCBI chr 4:172,483,752...172,851,623
Ensembl chr 4:172,484,345...172,850,544
JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 multiple interactions EXP [Fructose co-treated with Dietary Fats] results in decreased expression of PIK3R1 protein CTD PMID:32259528 NCBI chr 2:32,878,942...32,963,611
Ensembl chr 2:32,882,032...32,963,631
JBrowse link
G Pklr pyruvate kinase L/R increases expression
multiple interactions
affects expression
affects degradation
ISO
EXP
Fructose results in increased expression of PKLR mRNA
Atorvastatin inhibits the reaction [Fructose results in increased expression of PKLR mRNA]; GCG protein affects the reaction [Fructose affects the degradation of PKLR mRNA]
Fructose affects the expression of PKLR mRNA
FGF21 gene mutant form inhibits the reaction [Fructose results in increased expression of PKLR mRNA]; lactisole inhibits the reaction [Fructose results in increased expression of PKLR mRNA]
CTD PMID:2193023 PMID:2414297 PMID:2824512 PMID:6526814 PMID:6759123 More... NCBI chr 2:174,543,008...174,551,863
Ensembl chr 2:174,543,039...174,551,870
JBrowse link
G Pkm pyruvate kinase M1/2 multiple interactions EXP [Fructose co-treated with bisphenol A] results in decreased expression of PKM protein CTD PMID:26930160 NCBI chr 8:60,057,629...60,079,600
Ensembl chr 8:60,057,402...60,079,599
JBrowse link
G Plat plasminogen activator, tissue type increases expression ISO Fructose results in increased expression of PLAT mRNA CTD PMID:31655124 NCBI chr16:69,240,582...69,265,177
Ensembl chr16:69,240,585...69,268,223
JBrowse link
G Pnpla2 patatin-like phospholipase domain containing 2 increases expression ISO Fructose results in increased expression of PNPLA2 protein CTD PMID:28257781 NCBI chr 1:196,552,723...196,557,805
Ensembl chr 1:196,552,723...196,557,805
JBrowse link
G Pomc proopiomelanocortin decreases expression EXP Fructose results in decreased expression of POMC mRNA CTD PMID:18627777 NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha increases expression
multiple interactions
decreases expression
EXP
ISO
Fructose results in increased expression of PPARA protein
[Plant Preparations co-treated with Fructose] results in increased expression of PPARA protein
Fructose results in decreased expression of PPARA protein
[dapagliflozin co-treated with Atorvastatin] inhibits the reaction [[Fructose co-treated with Dietary Fats] results in decreased expression of PPARA protein]; [Fructose co-treated with Dietary Fats] results in decreased expression of PPARA protein; Allopurinol inhibits the reaction [Fructose results in decreased expression of PPARA protein]; Atorvastatin inhibits the reaction [Fructose results in increased expression of PPARA protein]; Fenofibrate inhibits the reaction [Fructose results in decreased expression of and results in decreased activity of PPARA protein]; Fructose results in decreased expression of and results in decreased activity of PPARA protein; Quercetin inhibits the reaction [Fructose results in decreased expression of PPARA protein]; Rutin inhibits the reaction [Fructose results in decreased expression of PPARA protein]
CTD PMID:11934685 PMID:12065722 PMID:22426011 PMID:27531227 PMID:28257781 More... NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
JBrowse link
G Ppard peroxisome proliferator-activated receptor delta multiple interactions
decreases response to substance
ISO [PPARD mRNA results in decreased susceptibility to Fructose] which results in decreased expression of VLDLR mRNA; Fructose inhibits the reaction [PPARD mRNA results in decreased expression of VLDLR mRNA]; Fructose promotes the reaction [PPARD gene mutant form results in increased expression of VLDLR mRNA]; Fructose promotes the reaction [PPARD gene mutant form results in increased expression of VLDLR protein]; Fructose promotes the reaction [PPARD gene mutant form results in increased phosphorylation of NFE2L2 protein] CTD PMID:29289645 NCBI chr20:6,298,785...6,363,970
Ensembl chr20:6,298,785...6,363,968
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma increases expression
decreases activity
multiple interactions
EXP Fructose results in increased expression of PPARG mRNA
Fructose results in decreased activity of PPARG protein
[Dietary Fats co-treated with Fructose] results in decreased expression of PPARG protein; Carnitine inhibits the reaction [[Dietary Fats co-treated with Fructose] results in decreased expression of PPARG protein]; Fatty Acids, Omega-3 inhibits the reaction [[Dietary Fats co-treated with Fructose] results in decreased expression of PPARG protein]; geraniol inhibits the reaction [Fructose results in decreased activity of PPARG protein]; Metformin inhibits the reaction [[Dietary Fats co-treated with Fructose] results in decreased expression of PPARG protein]; Pioglitazone inhibits the reaction [Fructose results in decreased activity of PPARG protein]; Rosiglitazone promotes the reaction [Fructose results in increased expression of PPARG mRNA]
CTD PMID:19196556 PMID:25679220 PMID:30256492 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha decreases expression
multiple interactions
increases expression
ISO
EXP
Fructose results in decreased expression of PPARGC1A mRNA
[Fructose co-treated with Palmitic Acid] results in decreased expression of PPARGC1A protein; Fenofibrate inhibits the reaction [[Fructose co-treated with Palmitic Acid] results in decreased expression of PPARGC1A protein]
Fructose results in increased expression of PPARGC1A mRNA; Fructose results in increased expression of PPARGC1A protein
[Atorvastatin co-treated with dapagliflozin] inhibits the reaction [[Fructose co-treated with Dietary Fats] results in decreased expression of PPARGC1A protein]; [Fructose co-treated with Dietary Fats] results in decreased expression of PPARGC1A protein; [Ozone co-treated with Fructose] results in decreased expression of PPARGC1A mRNA; [Particulate Matter co-treated with Fructose] results in decreased expression of PPARGC1A mRNA; [Particulate Matter co-treated with Ozone co-treated with Fructose] results in decreased expression of PPARGC1A mRNA; dapagliflozin inhibits the reaction [[Fructose co-treated with Dietary Fats] results in decreased expression of PPARGC1A protein]; Rosiglitazone inhibits the reaction [Fructose results in increased expression of PPARGC1A protein]
CTD PMID:18063403 PMID:19196556 PMID:21212096 PMID:23968387 PMID:32259528 More... NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656
JBrowse link
G Prdx6 peroxiredoxin 6 multiple interactions EXP [Fructose co-treated with bisphenol A] results in increased expression of PRDX6 protein CTD PMID:26930160 NCBI chr13:73,528,746...73,539,295
Ensembl chr13:73,528,210...73,539,355
JBrowse link
G Prkca protein kinase C, alpha multiple interactions EXP [Atorvastatin co-treated with dapagliflozin] inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of and results in increased phosphorylation of PRKCA protein]; [Fructose co-treated with Dietary Fats] results in increased expression of and results in increased phosphorylation of PRKCA protein CTD PMID:32259528 NCBI chr10:92,889,390...93,288,013
Ensembl chr10:92,894,012...93,288,012
JBrowse link
G Prkcq protein kinase C, theta multiple interactions
increases phosphorylation
EXP Curcumin inhibits the reaction [Fructose results in increased phosphorylation of PRKCQ protein] CTD PMID:26713546 NCBI chr17:67,246,394...67,379,049
Ensembl chr17:67,246,394...67,378,704
JBrowse link
G Prkcz protein kinase C, zeta multiple interactions EXP [Atorvastatin co-treated with dapagliflozin] inhibits the reaction [[Fructose co-treated with Dietary Fats] results in decreased expression of PRKCZ protein]; [Fructose co-treated with Dietary Fats] results in decreased expression of PRKCZ protein; dapagliflozin inhibits the reaction [[Fructose co-treated with Dietary Fats] results in decreased expression of PRKCZ protein] CTD PMID:32259528 NCBI chr 5:165,817,786...165,930,386
Ensembl chr 5:165,819,466...165,930,367
JBrowse link
G Pten phosphatase and tensin homolog multiple interactions
increases expression
EXP tributylhexadecylphosphonium bromide inhibits the reaction [Fructose results in increased expression of PTEN protein] CTD PMID:26358169 NCBI chr 1:230,631,303...230,696,754
Ensembl chr 1:230,630,338...230,696,838
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression
multiple interactions
EXP Fructose results in increased expression of PTGS2 mRNA; Fructose results in increased expression of PTGS2 protein
Curcumin inhibits the reaction [Fructose results in increased expression of PTGS2 protein]; Kangen-karyu inhibits the reaction [Fructose results in increased expression of PTGS2 protein]; tributylhexadecylphosphonium bromide inhibits the reaction [Fructose results in increased expression of PTGS2 protein]
CTD PMID:14757778 PMID:17883899 PMID:26358169 PMID:26713546 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Ptma prothymosin alpha multiple interactions EXP PTMA protein inhibits the reaction [Fructose results in increased expression of IL1B protein]; PTMA protein inhibits the reaction [Fructose results in increased expression of IL6 protein] CTD PMID:15885234 NCBI chr 9:87,176,251...87,180,333
Ensembl chr 9:87,176,230...87,180,333
JBrowse link
G Pura purine rich element binding protein A multiple interactions EXP [Fructose co-treated with bisphenol A] results in increased expression of PURA protein CTD PMID:26930160
G Pycard PYD and CARD domain containing multiple interactions
increases expression
EXP Allopurinol inhibits the reaction [Fructose results in increased expression of PYCARD protein]; Quercetin inhibits the reaction [Fructose results in increased expression of PYCARD protein]; Rutin inhibits the reaction [Fructose results in increased expression of PYCARD protein] CTD PMID:22426011 NCBI chr 1:182,601,657...182,603,013
Ensembl chr 1:182,601,174...182,602,955
JBrowse link
G Pyy peptide YY affects expression EXP Fructose affects the expression of PYY protein CTD PMID:18627777 NCBI chr10:87,061,155...87,062,278
Ensembl chr10:87,061,161...87,061,815
JBrowse link
G Rbmx RNA binding motif protein, X-linked multiple interactions EXP Fructose promotes the reaction [RBMX protein binds to SREBF1 promoter] CTD PMID:17188681 NCBI chr  X:135,305,237...135,314,806
Ensembl chr  X:135,305,325...135,314,743
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit affects localization
increases phosphorylation
decreases activity
multiple interactions
EXP Fructose affects the localization of RELA protein
Fructose results in increased phosphorylation of RELA protein
Fructose results in decreased activity of RELA protein
Allopurinol inhibits the reaction [Fructose results in increased phosphorylation of RELA protein]; Betaine inhibits the reaction [Fructose results in decreased activity of RELA protein]; galangin inhibits the reaction [Fructose affects the localization of RELA protein]; Genistein inhibits the reaction [Fructose affects the localization of RELA protein]; Metformin inhibits the reaction [Fructose results in increased phosphorylation of RELA protein]; Quercetin inhibits the reaction [Fructose results in increased phosphorylation of RELA protein]; resveratrol inhibits the reaction [Fructose results in increased phosphorylation of RELA protein]
CTD PMID:21704028 PMID:21708140 PMID:24491314 PMID:25108154 PMID:25559852 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Retn resistin decreases expression
multiple interactions
increases expression
EXP Fructose results in decreased expression of RETN mRNA
Metformin inhibits the reaction [Fructose results in increased expression of RETN protein]; resveratrol inhibits the reaction [Fructose results in increased expression of RETN protein]
CTD PMID:11741341 PMID:25108154 NCBI chr12:1,710,881...1,712,621
Ensembl chr12:1,710,881...1,712,620
JBrowse link
G Rxra retinoid X receptor alpha decreases expression ISO Fructose results in decreased expression of RXRA protein CTD PMID:28257781 NCBI chr 3:10,989,832...11,076,366
Ensembl chr 3:10,989,832...11,073,712
JBrowse link
G S100a11 S100 calcium binding protein A11 multiple interactions EXP [Fructose co-treated with bisphenol A] results in increased expression of S100A11 protein CTD PMID:26930160 NCBI chr 2:179,191,504...179,197,098
Ensembl chr 2:179,191,715...179,197,044
JBrowse link
G S100a6 S100 calcium binding protein A6 decreases expression EXP Fructose results in decreased expression of S100A6 mRNA CTD PMID:15150374 NCBI chr 2:176,100,619...176,102,181
Ensembl chr 2:176,100,899...176,102,180
JBrowse link
G Scarb1 scavenger receptor class B, member 1 decreases expression EXP Fructose results in decreased expression of SCARB1 mRNA CTD PMID:19193814 NCBI chr12:31,296,143...31,362,649
Ensembl chr12:31,296,156...31,362,647
JBrowse link
G Scd stearoyl-CoA desaturase multiple interactions
increases expression
affects response to substance
ISO
EXP
FGF21 gene mutant form inhibits the reaction [Fructose results in increased expression of SCD1 mRNA]; Phenylbutyrates inhibits the reaction [Fructose results in increased expression of SCD1 mRNA]; SCD1 affects the reaction [Fructose results in increased expression of SREBF1 protein]; SCD1 gene mutant form inhibits the reaction [Fructose results in increased abundance of Triglycerides]; SCD1 gene mutant form inhibits the reaction [Fructose results in increased expression of ACACA mRNA]; SCD1 gene mutant form inhibits the reaction [Fructose results in increased expression of FASN mRNA]; SCD1 gene mutant form inhibits the reaction [Fructose results in increased expression of SREBF1 mRNA]; SCD1 gene mutant form inhibits the reaction [Fructose results in increased expression of SREBF1 protein]; Triolein inhibits the reaction [SCD1 gene mutant form inhibits the reaction [Fructose results in increased abundance of Triglycerides]]; Triolein inhibits the reaction [SCD1 gene mutant form inhibits the reaction [Fructose results in increased expression of ACACA mRNA]]; Triolein inhibits the reaction [SCD1 gene mutant form inhibits the reaction [Fructose results in increased expression of FASN mRNA]]; Triolein inhibits the reaction [SCD1 gene mutant form inhibits the reaction [Fructose results in increased expression of SREBF1 mRNA]]; Triolein inhibits the reaction [SCD1 gene mutant form inhibits the reaction [Fructose results in increased expression of SREBF1 protein]]
[Fructose co-treated with Copper deficiency] results in decreased expression of SCD1 mRNA; Atorvastatin inhibits the reaction [Fructose results in increased expression of SCD1 mRNA]; gadolinium chloride promotes the reaction [[Fructose co-treated with Copper deficiency] results in decreased expression of SCD1 mRNA]; Tea inhibits the reaction [Fructose results in increased expression of SCD1 mRNA]
Fructose results in increased expression of SCD mRNA; Fructose results in increased expression of SCD1 mRNA
Fructose results in increased expression of SCD1 mRNA; Fructose results in increased expression of SCD1 protein
SCD1 affects the susceptibility to Fructose
CTD PMID:7961698 PMID:15066988 PMID:18063403 PMID:19053045 PMID:19193814 More... NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562
JBrowse link
G Serpine1 serpin family E member 1 increases secretion
increases expression
multiple interactions
EXP Fructose results in increased secretion of SERPINE1 protein
Fructose results in increased expression of SERPINE1 mRNA; Fructose results in increased expression of SERPINE1 protein
Atorvastatin inhibits the reaction [Fructose results in increased expression of SERPINE1 mRNA]; Metformin inhibits the reaction [Fructose results in increased expression of SERPINE1 protein]; Progesterone inhibits the reaction [Fructose results in increased expression of SERPINE1 mRNA]; Progesterone inhibits the reaction [Fructose results in increased expression of SERPINE1 protein]; Resveratrol inhibits the reaction [Fructose results in increased expression of SERPINE1 protein]
CTD PMID:19165636 PMID:21122807 PMID:23016136 PMID:25108154 NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657
JBrowse link
G Sgk1 serum/glucocorticoid regulated kinase 1 increases expression
multiple interactions
ISO Fructose results in increased expression of SGK1 mRNA
SGK1 gene affects the susceptibility to [Fructose co-treated with Sodium Chloride, Dietary]
CTD PMID:16284089 NCBI chr 1:22,980,257...23,098,122
Ensembl chr 1:22,980,261...23,098,283
JBrowse link
G Shbg sex hormone binding globulin multiple interactions
decreases expression
ISO Cerulenin inhibits the reaction [Fructose results in decreased expression of SHBG protein]; Fructose affects the reaction [NR2F1 protein binds to SHBG promoter] CTD PMID:17992261 NCBI chr10:54,332,939...54,350,409
Ensembl chr10:54,332,941...54,351,057
JBrowse link
G Si sucrase-isomaltase increases expression ISO
EXP
Fructose results in increased expression of SI mRNA CTD PMID:10222385 PMID:11242478 PMID:17786952 NCBI chr 2:157,505,893...157,586,228
Ensembl chr 2:157,506,342...157,585,260
JBrowse link
G Sirt1 sirtuin 1 multiple interactions
decreases expression
increases expression
ISO
EXP
SIRT1 protein affects the reaction [Fructose results in increased expression of MYH6 mRNA]
[Fructose co-treated with Palmitic Acid] results in decreased expression of SIRT1 protein; Fenofibrate inhibits the reaction [[Fructose co-treated with Palmitic Acid] results in decreased expression of SIRT1 protein]
Fructose results in decreased expression of SIRT1 mRNA; Fructose results in decreased expression of SIRT1 protein
[6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in decreased activity of SIRT1 protein] inhibits the reaction [Fructose results in increased abundance of Cholesterol]; [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in decreased activity of SIRT1 protein] inhibits the reaction [Fructose results in increased abundance of Glucose]; [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in decreased activity of SIRT1 protein] inhibits the reaction [Fructose results in increased expression of ACACA mRNA]; [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in decreased activity of SIRT1 protein] inhibits the reaction [Fructose results in increased expression of HMGCR mRNA]; [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in decreased activity of SIRT1 protein] which results in decreased susceptibility to Fructose; [Niacinamide results in decreased activity of SIRT1 protein] inhibits the reaction [Fructose results in increased abundance of Cholesterol]; [Niacinamide results in decreased activity of SIRT1 protein] inhibits the reaction [Fructose results in increased abundance of Glucose]; [Niacinamide results in decreased activity of SIRT1 protein] inhibits the reaction [Fructose results in increased expression of ACACA mRNA]; [Niacinamide results in decreased activity of SIRT1 protein] inhibits the reaction [Fructose results in increased expression of HMGCR mRNA]; [Niacinamide results in decreased activity of SIRT1 protein] which results in decreased susceptibility to Fructose; Fructose results in increased expression of and results in increased activity of SIRT1 protein; Metformin inhibits the reaction [Fructose results in decreased expression of SIRT1 protein]; resveratrol inhibits the reaction [Fructose results in decreased expression of SIRT1 mRNA]; resveratrol inhibits the reaction [Fructose results in decreased expression of SIRT1 protein]
Fructose results in increased expression of SIRT1 protein
CTD PMID:18192211 PMID:21212096 PMID:25108154 PMID:26488877 PMID:32730863 NCBI chr20:25,307,143...25,329,260
Ensembl chr20:25,306,917...25,329,260
JBrowse link
G Slc22a1 solute carrier family 22 member 1 multiple interactions
decreases expression
EXP Allopurinol inhibits the reaction [Fructose results in decreased expression of SLC22A1 mRNA]; Allopurinol inhibits the reaction [Fructose results in decreased expression of SLC22A1 protein]; Quercetin inhibits the reaction [Fructose results in decreased expression of SLC22A1 mRNA]; Quercetin inhibits the reaction [Fructose results in decreased expression of SLC22A1 protein]; Rutin inhibits the reaction [Fructose results in decreased expression of SLC22A1 mRNA]; Rutin inhibits the reaction [Fructose results in decreased expression of SLC22A1 protein]
Fructose results in decreased expression of SLC22A1 mRNA; Fructose results in decreased expression of SLC22A1 protein
CTD PMID:19605544 NCBI chr 1:48,076,657...48,103,679
Ensembl chr 1:48,076,666...48,103,678
JBrowse link
G Slc22a12 solute carrier family 22 member 12 increases expression
multiple interactions
EXP Fructose results in increased expression of SLC22A12 mRNA; Fructose results in increased expression of SLC22A12 protein
Allopurinol inhibits the reaction [Fructose results in increased expression of SLC22A12 mRNA]; Allopurinol inhibits the reaction [Fructose results in increased expression of SLC22A12 protein]; Quercetin inhibits the reaction [Fructose results in increased expression of SLC22A12 mRNA]; Quercetin inhibits the reaction [Fructose results in increased expression of SLC22A12 protein]; Rutin inhibits the reaction [Fructose results in increased expression of SLC22A12 mRNA]; Rutin inhibits the reaction [Fructose results in increased expression of SLC22A12 protein]
CTD PMID:19605544 NCBI chr 1:203,845,039...203,852,496
Ensembl chr 1:203,845,048...203,853,555
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions
decreases expression
EXP Allopurinol inhibits the reaction [Fructose results in decreased expression of SLC22A2 mRNA]; Allopurinol inhibits the reaction [Fructose results in decreased expression of SLC22A2 protein]; Quercetin inhibits the reaction [Fructose results in decreased expression of SLC22A2 mRNA]; Quercetin inhibits the reaction [Fructose results in decreased expression of SLC22A2 protein]; Rutin inhibits the reaction [Fructose results in decreased expression of SLC22A2 mRNA]; Rutin inhibits the reaction [Fructose results in decreased expression of SLC22A2 protein]
Fructose results in decreased expression of SLC22A2 mRNA; Fructose results in decreased expression of SLC22A2 protein
CTD PMID:19605544 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
JBrowse link
G Slc22a5 solute carrier family 22 member 5 decreases expression
multiple interactions
EXP Fructose results in decreased expression of SLC22A5 protein
Allopurinol inhibits the reaction [Fructose results in decreased expression of SLC22A5 protein]; Quercetin inhibits the reaction [Fructose results in decreased expression of SLC22A5 protein]
CTD PMID:22426011 NCBI chr10:38,008,303...38,035,474
Ensembl chr10:38,008,311...38,035,309
JBrowse link
G Slc22a6 solute carrier family 22 member 6 multiple interactions
decreases expression
EXP Allopurinol inhibits the reaction [Fructose results in decreased expression of SLC22A6 mRNA]; Allopurinol inhibits the reaction [Fructose results in decreased expression of SLC22A6 protein]; Quercetin inhibits the reaction [Fructose results in decreased expression of SLC22A6 mRNA]; Quercetin inhibits the reaction [Fructose results in decreased expression of SLC22A6 protein]; Rutin inhibits the reaction [Fructose results in decreased expression of SLC22A6 mRNA]; Rutin inhibits the reaction [Fructose results in decreased expression of SLC22A6 protein]
Fructose results in decreased expression of SLC22A6 mRNA; Fructose results in decreased expression of SLC22A6 protein
CTD PMID:19605544 NCBI chr 1:205,522,579...205,531,179
Ensembl chr 1:205,522,729...205,531,173
JBrowse link
G Slc25a5 solute carrier family 25 member 5 multiple interactions EXP [Fructose co-treated with bisphenol A] results in decreased expression of SLC25A5 protein CTD PMID:26930160 NCBI chr  X:116,031,896...116,034,963
Ensembl chr  X:116,031,803...116,034,967
JBrowse link
G Slc27a2 solute carrier family 27 member 2 decreases expression ISO Fructose results in decreased expression of SLC27A2 protein CTD PMID:28257781 NCBI chr 3:113,804,728...113,842,208
Ensembl chr 3:113,804,728...113,842,208
JBrowse link
G Slc2a2 solute carrier family 2 member 2 multiple interactions
increases expression
increases transport
ISO
EXP
Fructose inhibits the reaction [SLC2A2 protein results in increased transport of Deoxyglucose]; Glucose inhibits the reaction [SLC2A2 protein results in increased transport of Fructose]; Maltose inhibits the reaction [SLC2A2 protein results in increased transport of Fructose]
Fructose results in increased expression of SLC2A2 mRNA
Dactinomycin inhibits the reaction [Fructose results in increased expression of SLC2A2 mRNA]
Fructose results in increased expression of and affects the localization of SLC2A2 protein
CTD PMID:1727734 PMID:8457197 PMID:10222385 PMID:12787936 PMID:12937289 More... NCBI chr 2:111,609,798...111,639,930
Ensembl chr 2:111,611,774...111,639,933
JBrowse link
G Slc2a4 solute carrier family 2 member 4 decreases expression
multiple interactions
increases expression
ISO
EXP
Fructose results in decreased expression of SLC2A4 mRNA
[Dietary Fats co-treated with Fructose] results in decreased expression of SLC2A4 protein; Carnitine inhibits the reaction [[Dietary Fats co-treated with Fructose] results in decreased expression of SLC2A4 protein]; Fatty Acids, Omega-3 inhibits the reaction [[Dietary Fats co-treated with Fructose] results in decreased expression of SLC2A4 protein]; Metformin inhibits the reaction [[Dietary Fats co-treated with Fructose] results in decreased expression of SLC2A4 protein]
Fructose results in increased expression of SLC2A4 mRNA
CTD PMID:15111496 PMID:18063403 PMID:30256492 NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565
JBrowse link
G Slc2a5 solute carrier family 2 member 5 multiple interactions
increases activity
increases expression
increases transport
increases uptake
affects expression
ISO
EXP
[Fructose results in increased abundance of Cyclic AMP] which results in increased stability of SLC2A5 mRNA; Colforsin promotes the reaction [Fructose results in increased expression of SLC2A5 mRNA]; Fructose promotes the reaction [PAIP2 protein binds to SLC2A5 3' UTR]
Fructose results in increased activity of SLC2A5 protein
SLC2A5 protein results in increased transport of Fructose
Fructose results in increased expression of SLC2A5 mRNA; Fructose results in increased expression of SLC2A5 protein
SLC2A5 protein results in increased uptake of Fructose
Fructose affects the expression of SLC2A5 mRNA
Fructose analog results in increased expression of SLC2A5 mRNA; Fructose results in increased expression of SLC2A5 mRNA; Fructose results in increased expression of SLC2A5 protein
1-((1-O-octadecyl-2-O-methylglycero)phospho)-3-deoxy-myo-inositol inhibits the reaction [Fructose results in increased expression of and results in increased activity of SLC2A5 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Fructose results in increased expression of and results in increased activity of SLC2A5 protein]; [[Colforsin results in increased abundance of Cyclic AMP] which results in increased expression of SLC2A5 protein] which results in increased uptake of Fructose; [Triiodothyronine co-treated with Fructose] results in increased expression of SLC2A5 mRNA; Cycloheximide inhibits the reaction [Fructose promotes the reaction [SLC2A5 protein results in increased uptake of Fructose]]; Dactinomycin inhibits the reaction [Fructose promotes the reaction [SLC2A5 protein results in increased uptake of Fructose]]; Dactinomycin inhibits the reaction [Fructose results in increased expression of SLC2A5 mRNA]; Dexamethasone promotes the reaction [Fructose results in increased activity of SLC2A5 protein]; Dexamethasone promotes the reaction [Fructose results in increased expression of SLC2A5 mRNA]; Fructose analog results in increased activity of [SLC2A5 protein results in increased uptake of Fructose]; Fructose promotes the reaction [SLC2A5 protein results in increased transport of Fructose]; Fructose promotes the reaction [SLC2A5 protein results in increased uptake of Fructose]; Fructose results in increased expression of and results in increased activity of SLC2A5 protein; Mifepristone inhibits the reaction [Dexamethasone promotes the reaction [Fructose results in increased activity of SLC2A5 protein]]; Mifepristone inhibits the reaction [Dexamethasone promotes the reaction [Fructose results in increased expression of SLC2A5 mRNA]]; Vanadates inhibits the reaction [Fructose results in increased activity of SLC2A5 protein]; Vanadates inhibits the reaction [Fructose results in increased expression of SLC2A5 mRNA]; wortmannin inhibits the reaction [Fructose results in increased expression of and results in increased activity of SLC2A5 protein]
lactisole inhibits the reaction [Fructose results in increased expression of SLC2A5 mRNA]
CTD PMID:1634504 PMID:8037665 PMID:8048533 PMID:8404647 PMID:8554516 More... NCBI chr 5:160,583,055...160,609,994
Ensembl chr 5:160,583,234...160,611,106
JBrowse link
G Slc2a7 solute carrier family 2 member 7 increases transport ISO SLC2A7 protein results in increased transport of Fructose CTD PMID:15033637 PMID:17710649 NCBI chr 5:160,624,793...160,643,994
Ensembl chr 5:160,624,793...160,643,514
JBrowse link
G Slc2a9 solute carrier family 2 member 9 increases transport
increases expression
multiple interactions
ISO
EXP
SLC2A9 protein results in increased transport of Fructose
Fructose results in increased expression of SLC2A9 mRNA SNP; Fructose results in increased expression of SLC2A9 protein SNP
Allopurinol inhibits the reaction [Fructose results in increased expression of SLC2A9 mRNA SNP]; Allopurinol inhibits the reaction [Fructose results in increased expression of SLC2A9 protein SNP]; Quercetin inhibits the reaction [Fructose results in increased expression of SLC2A9 mRNA SNP]; Quercetin inhibits the reaction [Fructose results in increased expression of SLC2A9 protein SNP]; Rutin inhibits the reaction [Fructose results in increased expression of SLC2A9 mRNA SNP]; Rutin inhibits the reaction [Fructose results in increased expression of SLC2A9 protein SNP]
Fructose promotes the reaction [SLC2A9 protein alternative form results in increased transport of Uric Acid]
CTD PMID:17710649 PMID:18842065 PMID:19605544 NCBI chr14:72,328,334...72,461,981
Ensembl chr14:72,328,320...72,461,981
JBrowse link
G Slc31a1 solute carrier family 31 member 1 multiple interactions EXP Fructose inhibits the reaction [Copper deficiency results in increased expression of SLC31A1 protein] CTD PMID:21781943 NCBI chr 5:75,814,744...75,844,241
Ensembl chr 5:75,814,743...75,844,228
JBrowse link
G Slc34a2 solute carrier family 34 member 2 decreases expression
multiple interactions
affects expression
EXP Fructose results in decreased expression of SLC34A2 mRNA
tungstate promotes the reaction [Fructose results in decreased expression of SLC34A2 mRNA]; Vanadates promotes the reaction [Fructose results in decreased expression of SLC34A2 mRNA]
Fructose affects the expression of SLC34A2 mRNA
CTD PMID:15150374 PMID:18400728 NCBI chr14:57,910,931...57,930,236
Ensembl chr14:57,910,480...57,930,436
JBrowse link
G Slc37a4 solute carrier family 37 member 4 increases expression EXP Fructose results in increased expression of SLC37A4 mRNA CTD PMID:16920846 NCBI chr 8:44,723,216...44,729,301
Ensembl chr 8:44,723,339...44,729,301
JBrowse link
G Slc46a1 solute carrier family 46 member 1 multiple interactions EXP [Folic Acid affects the susceptibility to Fructose] which affects the expression of SLC46A1 mRNA CTD PMID:31612177 NCBI chr10:63,361,504...63,367,940
Ensembl chr10:63,361,486...63,368,848
JBrowse link
G Slc5a1 solute carrier family 5 member 1 multiple interactions
increases expression
ISO
EXP
lactisole inhibits the reaction [Fructose results in increased expression of SLC5A1 mRNA]
Fructose results in increased expression of SLC5A1 mRNA; Fructose results in increased expression of SLC5A1 protein
CTD PMID:8048533 PMID:10222385 PMID:11242478 PMID:12937289 PMID:17786952 NCBI chr14:77,553,990...77,618,589
Ensembl chr14:77,553,843...77,618,547
JBrowse link
G Slc8a1 solute carrier family 8 member A1 multiple interactions ISO [Fructose co-treated with Dietary Fats] results in decreased expression of SLC8A1 mRNA; troxerutin inhibits the reaction [[Fructose co-treated with Dietary Fats] results in decreased expression of SLC8A1 mRNA] CTD PMID:28916335 NCBI chr 6:13,194,609...13,547,369
Ensembl chr 6:13,194,662...13,535,628
JBrowse link
G Soat2 sterol O-acyltransferase 2 decreases expression EXP Fructose results in decreased expression of SOAT2 mRNA CTD PMID:19193814 NCBI chr 7:133,281,818...133,294,915
Ensembl chr 7:133,281,818...133,294,915
JBrowse link
G Socs3 suppressor of cytokine signaling 3 increases expression
multiple interactions
EXP Fructose results in increased expression of SOCS3 mRNA; Fructose results in increased expression of SOCS3 protein
[Fenofibrate co-treated with Resveratrol] inhibits the reaction [Fructose results in increased expression of SOCS3 mRNA]; Fenofibrate inhibits the reaction [Fructose results in increased expression of SOCS3 mRNA]; Quercetin inhibits the reaction [Fructose results in increased expression of SOCS3 protein]; Resveratrol inhibits the reaction [Fructose results in increased expression of SOCS3 mRNA]; Rutin inhibits the reaction [Fructose results in increased expression of SOCS3 protein]
CTD PMID:21122807 PMID:22426011 PMID:23533474 PMID:26973390 NCBI chr10:103,193,909...103,197,322
Ensembl chr10:103,193,537...103,197,787
JBrowse link
G Sod1 superoxide dismutase 1 affects binding
decreases expression
multiple interactions
decreases activity
increases activity
ISO
EXP
Fructose binds to SOD1 protein mutant form
Fructose results in decreased expression of SOD1 mRNA; Fructose results in decreased expression of SOD1 protein
[Fructose co-treated with Copper deficiency] results in decreased expression of SOD1 protein
Fructose results in decreased activity of SOD1 protein
Fructose results in increased activity of SOD1 protein
Fructose promotes the reaction [SOD1 protein mutant form results in increased chemical synthesis of Hydrogen Peroxide]
CTD PMID:11817707 PMID:12626432 PMID:16815490 PMID:20470786 PMID:21781943 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
JBrowse link
G Sord sorbitol dehydrogenase multiple interactions
increases glycation
EXP
ISO
[Fructose results in increased glycation of SORD protein] which results in decreased activity of SORD protein
[SORD protein results in increased metabolism of Sorbitol] which results in increased abundance of Fructose
CTD PMID:8761460 PMID:32367058 NCBI chr 3:109,184,697...109,216,133
Ensembl chr 3:109,184,676...109,216,133
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions
increases expression
affects localization
affects response to substance
ISO
EXP
Phenylbutyrates inhibits the reaction [Fructose affects the localization of SREBF1 protein alternative form]; Phenylbutyrates inhibits the reaction [Fructose results in increased expression of SREBF1 mRNA]; SCD1 affects the reaction [Fructose results in increased expression of SREBF1 protein]; SCD1 gene mutant form inhibits the reaction [Fructose results in increased expression of SREBF1 mRNA]; SCD1 gene mutant form inhibits the reaction [Fructose results in increased expression of SREBF1 protein]; Triolein inhibits the reaction [SCD1 gene mutant form inhibits the reaction [Fructose results in increased expression of SREBF1 mRNA]]; Triolein inhibits the reaction [SCD1 gene mutant form inhibits the reaction [Fructose results in increased expression of SREBF1 protein]]
Fructose results in increased expression of SREBF1 mRNA; Fructose results in increased expression of SREBF1 protein
[Atorvastatin co-treated with dapagliflozin] inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of SREBF1 protein]; [Fenofibrate co-treated with Resveratrol] inhibits the reaction [Fructose results in increased expression of SREBF1 mRNA]; [Fructose co-treated with Copper deficiency] results in increased expression of SREBF1 protein; [Fructose co-treated with Dietary Fats] results in increased expression of SREBF1 protein; Atorvastatin inhibits the reaction [Fructose results in increased activity of SREBF1 protein]; dapagliflozin inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of SREBF1 protein]; Fructose promotes the reaction [RBMX protein binds to SREBF1 promoter]; Fructose results in increased expression of and results in increased activity of SREBF1 protein; gadolinium chloride inhibits the reaction [[Fructose co-treated with Copper deficiency] results in increased expression of SREBF1 protein]; Resveratrol inhibits the reaction [Fructose results in increased expression of SREBF1 mRNA]; Rosiglitazone inhibits the reaction [Fructose results in increased expression of SREBF1 mRNA]; Tea inhibits the reaction [Fructose results in increased expression of SREBF1 mRNA]
SREBF1 promoter SNP affects the susceptibility to Fructose
CTD PMID:10913129 PMID:11934685 PMID:15066988 PMID:15123654 PMID:17188681 More... NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650
JBrowse link
G Stat3 signal transducer and activator of transcription 3 increases phosphorylation
decreases phosphorylation
multiple interactions
EXP Fructose results in increased phosphorylation of STAT3 protein
Fructose results in decreased phosphorylation of STAT3 protein
Quercetin inhibits the reaction [Fructose results in decreased phosphorylation of STAT3 protein]; Quercetin inhibits the reaction [Fructose results in increased phosphorylation of STAT3 protein]; Rutin inhibits the reaction [Fructose results in increased phosphorylation of STAT3 protein]
CTD PMID:22426011 PMID:23533474 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
JBrowse link
G Steap4 STEAP4 metalloreductase multiple interactions EXP [Dietary Fats co-treated with Fructose] results in increased expression of STEAP4 mRNA CTD PMID:19632207 NCBI chr 4:26,077,182...26,099,859
Ensembl chr 4:26,054,671...26,099,859
JBrowse link
G Tfam transcription factor A, mitochondrial increases expression EXP Fructose results in increased expression of TFAM protein CTD PMID:11934685 NCBI chr20:17,356,243...17,368,293
Ensembl chr20:17,356,197...17,368,292
JBrowse link
G Tgfb1 transforming growth factor, beta 1 decreases expression
multiple interactions
increases expression
EXP
ISO
Fructose results in decreased expression of TGFB1 mRNA
[FGF21 gene mutant form results in increased susceptibility to Fructose] which results in increased expression of TGFB1 mRNA
Fructose results in increased expression of TGFB1 mRNA; Fructose results in increased expression of TGFB1 protein
[Fenofibrate co-treated with Resveratrol] inhibits the reaction [Fructose results in increased expression of TGFB1 mRNA]; [Streptozocin co-treated with Fructose] results in increased expression of and results in increased secretion of TGFB1 protein; betanin inhibits the reaction [Fructose results in increased expression of TGFB1 protein]; dapagliflozin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of and results in increased secretion of TGFB1 protein]; dapagliflozin promotes the reaction [Metformin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of and results in increased secretion of TGFB1 protein]]; Fenofibrate inhibits the reaction [Fructose results in increased expression of TGFB1 mRNA]; galangin inhibits the reaction [Fructose results in increased expression of TGFB1 protein]; Genistein inhibits the reaction [Fructose results in increased expression of TGFB1 protein]; Metformin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of and results in increased secretion of TGFB1 protein]; Resveratrol inhibits the reaction [Fructose results in increased expression of TGFB1 mRNA]
CTD PMID:15150374 PMID:21704028 PMID:21708140 PMID:25559852 PMID:26973390 More... NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Tgfb2 transforming growth factor, beta 2 multiple interactions ISO [FGF21 gene mutant form results in increased susceptibility to Fructose] which results in increased expression of TGFB2 mRNA CTD PMID:28123933 NCBI chr13:98,160,075...98,261,771
Ensembl chr13:98,160,087...98,261,405
JBrowse link
G Th tyrosine hydroxylase increases expression ISO Fructose results in increased expression of TH mRNA CTD PMID:16843071 NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767
JBrowse link
G Thrsp thyroid hormone responsive multiple interactions EXP Fructose inhibits the reaction [Streptozocin results in decreased expression of THRSP mRNA] CTD PMID:2177838 NCBI chr 1:151,723,415...151,727,740
Ensembl chr 1:151,723,086...151,728,075
JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions
increases expression
EXP
ISO
[gadolinium chloride co-treated with Fructose co-treated with Copper deficiency] results in decreased expression of TLR4 mRNA
Fructose results in increased expression of TLR4 protein
[Fructose co-treated with Ethanol] results in increased expression of TLR4 mRNA
CTD PMID:25813056 PMID:26858005 PMID:31672515 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases secretion
increases expression
EXP
ISO
2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [caryophyllene inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of TNF protein]]; [Dietary Fats co-treated with Fructose] results in increased expression of TNF protein; [Fenofibrate co-treated with Resveratrol] inhibits the reaction [Fructose results in increased expression of and results in increased secretion of TNF protein]; [gadolinium chloride co-treated with Fructose co-treated with Copper deficiency] results in decreased expression of TNF mRNA; [Particulate Matter co-treated with Ozone] promotes the reaction [Fructose results in increased expression of TNF mRNA]; [Streptozocin co-treated with Fructose] results in increased expression of and results in increased secretion of TNF protein; Allopurinol inhibits the reaction [Fructose results in increased expression of TNF protein]; caffeic acid phenethyl ester inhibits the reaction [Fructose results in increased expression of TNF protein]; caryophyllene inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of TNF protein]; Curcumin inhibits the reaction [Fructose results in increased expression of TNF protein]; dapagliflozin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of and results in increased secretion of TNF protein]; dapagliflozin promotes the reaction [Metformin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of and results in increased secretion of TNF protein]]; Fenofibrate inhibits the reaction [Fructose results in increased expression of and results in increased secretion of TNF protein]; Fructose inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of TNF protein]; Fructose results in increased expression of and results in increased secretion of TNF protein; galangin inhibits the reaction [Fructose results in increased expression of TNF mRNA]; galangin inhibits the reaction [Fructose results in increased expression of TNF protein]; Genistein inhibits the reaction [Fructose results in increased expression of TNF protein]; geraniol inhibits the reaction [Fructose results in increased secretion of TNF protein]; iodopravadoline inhibits the reaction [caryophyllene inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of TNF protein]]; Metformin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of and results in increased secretion of TNF protein]; Metformin inhibits the reaction [Fructose results in increased expression of TNF protein]; Ozone promotes the reaction [Fructose results in increased expression of TNF mRNA]; Particulate Matter promotes the reaction [Fructose results in increased expression of TNF mRNA]; Pioglitazone inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of TNF protein]; Pioglitazone inhibits the reaction [Fructose results in increased secretion of TNF protein]; Quercetin inhibits the reaction [Fructose results in increased expression of TNF protein]; Resveratrol inhibits the reaction [Fructose results in increased expression of and results in increased secretion of TNF protein]; Resveratrol inhibits the reaction [Fructose results in increased expression of TNF protein]; Rutin inhibits the reaction [Fructose results in increased expression of TNF protein]; tributylhexadecylphosphonium bromide inhibits the reaction [Fructose results in increased expression of TNF protein]
Fructose promotes the reaction [Ethanol results in increased expression of TNF mRNA]
Fructose results in increased expression of TNF mRNA; Fructose results in increased expression of TNF protein
CTD PMID:10090849 PMID:21704028 PMID:21708140 PMID:22426011 PMID:23968387 More... NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Traf6 TNF receptor associated factor 6 multiple interactions ISO Fructose inhibits the reaction [Ethanol results in increased expression of TRAF6 protein]; Fructose promotes the reaction [Ethanol results in increased expression of TRAF6 mRNA] CTD PMID:26858005 NCBI chr 3:87,963,517...87,988,316
Ensembl chr 3:87,963,514...87,983,507
JBrowse link
G Trap1 TNF receptor-associated protein 1 multiple interactions
decreases expression
EXP [Fructose co-treated with bisphenol A] results in increased expression of TRAP1 protein
Fructose results in decreased expression of TRAP1 protein
CTD PMID:26930160 NCBI chr10:11,464,882...11,498,931
Ensembl chr10:11,464,821...11,498,981
JBrowse link
G Trib3 tribbles pseudokinase 3 increases expression
multiple interactions
EXP
ISO
Fructose results in increased expression of TRIB3 mRNA
Phenylbutyrates inhibits the reaction [Fructose results in increased expression of TRIB3 mRNA]
CTD PMID:18497449 PMID:22698815 NCBI chr 3:140,809,634...140,815,230
Ensembl chr 3:140,809,043...140,814,497
JBrowse link
G Ttr transthyretin multiple interactions EXP [Fructose co-treated with bisphenol A] results in increased expression of TTR protein CTD PMID:26930160 NCBI chr18:11,941,791...11,951,008
Ensembl chr18:11,943,789...11,951,008
JBrowse link
G Txnip thioredoxin interacting protein increases expression
multiple interactions
EXP Fructose results in increased expression of TXNIP protein
Allopurinol inhibits the reaction [Fructose results in increased expression of TXNIP protein]; Quercetin inhibits the reaction [Fructose results in increased expression of TXNIP protein]
CTD PMID:24491314 NCBI chr 2:184,093,079...184,096,882
Ensembl chr 2:184,092,991...184,096,886
JBrowse link
G Ucp1 uncoupling protein 1 multiple interactions
decreases expression
EXP Fructose promotes the reaction [[Ozone co-treated with Particulate Matter] results in decreased expression of UCP1 mRNA]; Fructose promotes the reaction [Ozone results in decreased expression of UCP1 mRNA]; Fructose promotes the reaction [Particulate Matter results in decreased expression of UCP1 mRNA]
Fructose results in decreased expression of UCP1 mRNA
CTD PMID:23968387 NCBI chr19:24,808,782...24,816,853
Ensembl chr19:24,808,783...24,816,852
JBrowse link
G Ucp3 uncoupling protein 3 increases expression EXP Fructose results in increased expression of UCP3 protein CTD PMID:11934685 NCBI chr 1:154,815,777...154,828,764
Ensembl chr 1:154,815,777...154,828,762
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 increases expression
multiple interactions
EXP
ISO
Fructose results in increased expression of VCAM1 mRNA
2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [caryophyllene inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of VCAM1 protein]]; [Dietary Fats co-treated with Fructose] results in increased expression of VCAM1 protein; caryophyllene inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of VCAM1 protein]; iodopravadoline inhibits the reaction [caryophyllene inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of VCAM1 protein]]; Pioglitazone inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of VCAM1 protein]
CTD PMID:17587757 PMID:30343038 PMID:31655124 NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958
JBrowse link
G Vcl vinculin multiple interactions
decreases expression
EXP [Fructose co-treated with bisphenol A] results in decreased expression of VCL protein
Fructose results in decreased expression of VCL protein
CTD PMID:26930160 NCBI chr15:3,265,776...3,355,586
Ensembl chr15:3,265,815...3,355,606
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions EXP [bisphenol A co-treated with Fructose] results in increased expression of VEGFA mRNA CTD PMID:27622962 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link
G Vldlr very low density lipoprotein receptor multiple interactions ISO [PPARD mRNA results in decreased susceptibility to Fructose] which results in decreased expression of VLDLR mRNA; Fructose inhibits the reaction [PPARD mRNA results in decreased expression of VLDLR mRNA]; Fructose promotes the reaction [PPARD gene mutant form results in increased expression of VLDLR mRNA]; Fructose promotes the reaction [PPARD gene mutant form results in increased expression of VLDLR protein] CTD PMID:29289645 NCBI chr 1:224,813,539...224,850,400
Ensembl chr 1:224,814,377...224,845,920
JBrowse link
G Vnn1 vanin 1 multiple interactions EXP [Streptozocin co-treated with Fructose] results in increased expression of VNN1 mRNA; dapagliflozin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of VNN1 mRNA]; Metformin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of VNN1 mRNA] CTD PMID:30551545 NCBI chr 1:21,537,084...21,547,395
Ensembl chr 1:21,537,094...21,547,395
JBrowse link
G Xbp1 X-box binding protein 1 affects localization ISO Fructose affects the localization of XBP1 protein CTD PMID:22698815 NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693
JBrowse link
G Xdh xanthine dehydrogenase multiple interactions
increases activity
ISO
EXP
Fructose promotes the reaction [XDH protein results in increased chemical synthesis of Uric Acid]; XDH protein promotes the reaction [Fructose results in increased abundance of Reactive Oxygen Species]
Glutamine inhibits the reaction [Fructose results in increased activity of XDH protein]
CTD PMID:19158351 PMID:31233715 NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268
JBrowse link
G Ybx3 Y box binding protein 3 multiple interactions EXP [Fructose co-treated with bisphenol A] results in increased expression of YBX3 protein CTD PMID:26930160 NCBI chr 4:165,129,747...165,153,101
Ensembl chr 4:165,129,758...165,153,161
JBrowse link
keto-D-fructose 1,6-bisphosphate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gapdh glyceraldehyde-3-phosphate dehydrogenase multiple interactions EXP [GAPDH protein co-treated with fructose-1,6-diphosphate co-treated with NAD] results in increased chemical synthesis of sodium arsenite; [GAPDH protein co-treated with fructose-1,6-diphosphate co-treated with NAD] results in increased reduction of sodium arsenate analog; heptelidic acid inhibits the reaction [[GAPDH protein co-treated with fructose-1,6-diphosphate co-treated with NAD] results in increased reduction of sodium arsenate analog] CTD PMID:15788719 NCBI chr 4:157,962,312...157,967,158
Ensembl chr 4:157,962,343...157,966,235
JBrowse link
G Idh2 isocitrate dehydrogenase (NADP(+)) 2 multiple interactions
increases abundance
ISO Triazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of fructose-1,6-diphosphate] CTD PMID:27469509 NCBI chr 1:134,038,644...134,057,969
Ensembl chr 1:134,029,772...134,058,025
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO fructose-1,6-diphosphate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein] CTD PMID:22227475 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO fructose-1,6-diphosphate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein] CTD PMID:22227475 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
decreases degradation
ISO fructose-1,6-diphosphate inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; fructose-1,6-diphosphate inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]
fructose-1,6-diphosphate results in decreased degradation of NOS2 mRNA
CTD PMID:22227475 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
psicose term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO psicose inhibits the reaction [Glucose results in increased expression of CCL2 mRNA]; psicose inhibits the reaction [Glucose results in increased expression of CCL2 protein] CTD PMID:17655880 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
royal jelly term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO royal jelly inhibits the reaction [Nicotine results in decreased expression of BCL2 mRNA] CTD PMID:30896085 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Casp3 caspase 3 multiple interactions ISO royal jelly inhibits the reaction [Nicotine results in increased expression of CASP3 mRNA] CTD PMID:30896085 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Cat catalase multiple interactions EXP
ISO
royal jelly inhibits the reaction [Cisplatin results in decreased activity of CAT protein]
royal jelly inhibits the reaction [Nicotine results in decreased activity of CAT protein]
CTD PMID:20369241 PMID:30896085 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions
increases activity
affects binding
ISO Estradiol inhibits the reaction [royal jelly binds to ESR1 protein]; royal jelly binds to and results in increased activity of ESR1 protein; royal jelly inhibits the reaction [Estradiol binds to ESR1 protein]
royal jelly results in increased activity of ESR1 protein
CTD PMID:15946813 PMID:17287592 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Esr2 estrogen receptor 2 multiple interactions
affects binding
ISO Estradiol inhibits the reaction [royal jelly binds to ESR2 protein]; royal jelly binds to and results in increased activity of ESR2 protein; royal jelly inhibits the reaction [Estradiol binds to ESR2 protein] CTD PMID:15946813 PMID:17287592 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919
JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions ISO royal jelly inhibits the reaction [Nicotine results in decreased expression of PCNA protein] CTD PMID:30896085 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
JBrowse link
G Tff1 trefoil factor 1 increases expression ISO royal jelly results in increased expression of TFF1 mRNA CTD PMID:15946813 NCBI chr20:9,235,736...9,239,597
Ensembl chr20:9,235,736...9,239,597
JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO royal jelly inhibits the reaction [Nicotine results in increased expression of TRP53 mRNA] CTD PMID:30896085 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Vegfa vascular endothelial growth factor A increases expression ISO
EXP
royal jelly results in increased expression of VEGFA mRNA CTD PMID:15946813 PMID:17287592 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link
sedoheptulose 1,7-bisphosphate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Idh2 isocitrate dehydrogenase (NADP(+)) 2 multiple interactions
increases abundance
ISO Triazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of sedoheptulose 1,7-bisphosphate] CTD PMID:27469509 NCBI chr 1:134,038,644...134,057,969
Ensembl chr 1:134,029,772...134,058,025
JBrowse link
sorbose term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Oat ornithine aminotransferase multiple interactions
decreases activity
EXP Sorbose inhibits the reaction [Cyclic AMP results in increased activity of OAT protein]
Sorbose results in decreased activity of OAT protein
CTD PMID:2827574 NCBI chr 1:187,347,862...187,367,644
Ensembl chr 1:187,347,865...187,367,682
JBrowse link
tagatose term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl2 C-C motif chemokine ligand 2 increases secretion ISO tagatose results in increased secretion of CCL2 protein CTD PMID:19158351 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
topiramate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions
increases expression
EXP Amino Acids, Peptides, and Proteins inhibits the reaction [topiramate results in increased expression of ABCB1 protein] CTD PMID:18473823 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 increases expression EXP topiramate results in increased expression of ABCC1 protein CTD PMID:18473823 NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 increases expression EXP topiramate results in increased expression of ABCC2 protein CTD PMID:18473823 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
JBrowse link
G Acadsb acyl-CoA dehydrogenase, short/branched chain increases expression EXP topiramate results in increased expression of ACADSB mRNA CTD PMID:16979414 NCBI chr 1:186,188,939...186,227,796
Ensembl chr 1:186,188,987...186,230,379
JBrowse link
G Acsl4 acyl-CoA synthetase long-chain family member 4 decreases expression EXP topiramate results in decreased expression of ACSL4 mRNA CTD PMID:16979414 NCBI chr  X:105,942,794...106,006,573
Ensembl chr  X:105,942,799...106,006,427
JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing increases expression
increases secretion
ISO topiramate results in increased expression of ADIPOQ mRNA
topiramate results in increased secretion of ADIPOQ protein
CTD PMID:12927809 NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564
JBrowse link
G Adra2a adrenoceptor alpha 2A increases expression ISO topiramate results in increased expression of ADRA2A mRNA CTD PMID:22489711 NCBI chr 1:253,061,480...253,064,280
Ensembl chr 1:253,060,218...253,064,365
JBrowse link
G Agxt alanine--glyoxylate and serine--pyruvate aminotransferase increases expression EXP topiramate results in increased expression of AGXT mRNA CTD PMID:16979414 NCBI chr 9:93,675,384...93,685,337
Ensembl chr 9:93,675,384...93,685,336
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions EXP topiramate inhibits the reaction [3-nitropropionic acid results in decreased phosphorylation of AKT1 protein] CTD PMID:29753867 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Ass1 argininosuccinate synthase 1 decreases expression EXP topiramate results in decreased expression of ASS1 mRNA CTD PMID:16979414 NCBI chr 3:14,747,355...14,796,909
Ensembl chr 3:14,747,368...14,796,903
JBrowse link
G Avpr1a arginine vasopressin receptor 1A decreases expression EXP topiramate results in decreased expression of AVPR1A mRNA CTD PMID:16979414 NCBI chr 7:58,114,306...58,118,230
Ensembl chr 7:58,114,284...58,122,215
JBrowse link
G Bdnf brain-derived neurotrophic factor multiple interactions EXP topiramate inhibits the reaction [3-nitropropionic acid results in decreased expression of BDNF protein] CTD PMID:29753867 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
JBrowse link
G Ca12 carbonic anhydrase 12 decreases activity ISO topiramate results in decreased activity of CA12 protein CTD PMID:21314129 NCBI chr 8:67,274,739...67,330,428
Ensembl chr 8:67,274,359...67,330,440
JBrowse link
G Ca3 carbonic anhydrase 3 multiple interactions ISO topiramate binds to and results in decreased activity of CA3 protein CTD PMID:17826101 NCBI chr 2:86,770,418...86,780,011
Ensembl chr 2:86,770,420...86,784,280
JBrowse link
G Calca calcitonin-related polypeptide alpha multiple interactions EXP Topiramate inhibits the reaction [Potassium Chloride results in increased secretion of CALCA protein]; Topiramate inhibits the reaction [Protons results in increased secretion of CALCA protein]; Topiramate inhibits the reaction [S-nitro-N-acetylpenicillamine results in increased secretion of CALCA protein] CTD PMID:16942474 NCBI chr 1:168,878,212...168,883,176
Ensembl chr 1:168,878,214...168,883,105
JBrowse link
G Capn6 calpain 6 increases expression EXP topiramate results in increased expression of CAPN6 mRNA CTD PMID:16979414 NCBI chr  X:107,380,774...107,405,489
Ensembl chr  X:107,380,774...107,405,489
JBrowse link
G Car1 carbonic anhydrase 1 multiple interactions ISO topiramate binds to and results in decreased activity of CA1 protein CTD PMID:17826101 NCBI chr 2:86,829,436...86,872,209
Ensembl chr 2:86,861,897...86,872,208
JBrowse link
G Car2 carbonic anhydrase 2 multiple interactions
decreases activity
ISO topiramate binds to and results in decreased activity of CA2 protein
topiramate results in decreased activity of CA2 protein
CTD PMID:17826101 PMID:21314129 NCBI chr 2:86,741,625...86,756,766
Ensembl chr 2:86,741,626...86,756,818
JBrowse link
G Casp3 caspase 3 affects expression
multiple interactions
EXP topiramate affects the expression of CASP3 mRNA; topiramate affects the expression of CASP3 protein
topiramate inhibits the reaction [3-nitropropionic acid results in increased activity of CASP3 protein]
CTD PMID:19148780 PMID:29753867 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha decreases expression EXP topiramate results in decreased expression of CEBPA mRNA CTD PMID:16979414 NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412
JBrowse link
G Chka choline kinase alpha decreases expression EXP topiramate results in decreased expression of CHKA mRNA CTD PMID:16979414 NCBI chr 1:201,076,804...201,125,517
Ensembl chr 1:201,076,860...201,125,516
JBrowse link
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit decreases expression EXP topiramate results in decreased expression of CHRNA7 mRNA CTD PMID:16979414 NCBI chr 1:116,715,286...116,837,223
Ensembl chr 1:116,714,711...116,837,240
JBrowse link
G Cited2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 decreases expression EXP topiramate results in decreased expression of CITED2 mRNA CTD PMID:16979414 NCBI chr 1:12,312,426...12,314,869
Ensembl chr 1:12,312,160...12,314,897
JBrowse link
G Cnr1 cannabinoid receptor 1 affects expression ISO topiramate affects the expression of CNR1 mRNA CTD PMID:22017514 NCBI chr 5:48,408,543...48,436,099
Ensembl chr 5:48,408,574...48,435,099
JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions EXP topiramate inhibits the reaction [3-nitropropionic acid results in decreased phosphorylation of CREB1 protein] CTD PMID:29753867 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 decreases activity ISO topiramate results in decreased activity of CYP17A1 protein CTD PMID:15730543 NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases activity
increases expression
ISO Topiramate results in increased activity of CYP3A4 protein
Topiramate results in increased expression of CYP3A4 mRNA; Topiramate results in increased expression of CYP3A4 protein
CTD PMID:14636322 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Drd2 dopamine receptor D2 increases expression ISO topiramate results in increased expression of DRD2 mRNA CTD PMID:22489711 NCBI chr 8:49,708,903...49,772,888
Ensembl chr 8:49,708,927...49,772,875
JBrowse link
G Dusp1 dual specificity phosphatase 1 increases expression EXP topiramate results in increased expression of DUSP1 mRNA CTD PMID:16979414 NCBI chr10:16,680,489...16,683,276 JBrowse link
G Fabp3 fatty acid binding protein 3 decreases expression EXP topiramate results in decreased expression of FABP3 mRNA CTD PMID:16979414 NCBI chr 5:142,651,962...142,658,707
Ensembl chr 5:142,651,956...142,658,718
JBrowse link
G Gabra1 gamma-aminobutyric acid type A receptor subunit alpha 1 multiple interactions EXP topiramate inhibits the reaction [[gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein co-treated with GABRB2 protein co-treated with GABRG2 protein]] which results in increased transport of Chlorides] CTD PMID:11123204 NCBI chr10:26,595,151...26,650,611
Ensembl chr10:26,595,160...26,650,864
JBrowse link
G Gabra2 gamma-aminobutyric acid type A receptor subunit alpha 2 multiple interactions EXP topiramate inhibits the reaction [[gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein co-treated with GABRB2 protein co-treated with GABRG2 protein]] which results in increased transport of Chlorides] CTD PMID:11123204 NCBI chr14:37,096,995...37,230,030
Ensembl chr14:37,097,279...37,228,944
JBrowse link
G Gabra6 gamma-aminobutyric acid type A receptor subunit alpha6 multiple interactions EXP topiramate promotes the reaction [[gamma-Aminobutyric Acid results in increased activity of [GABRA6 protein co-treated with GABRB2 protein co-treated with GABRG2 protein]] which results in increased transport of Chlorides] CTD PMID:11123204 NCBI chr10:26,810,411...26,825,768
Ensembl chr10:26,810,423...26,825,769
JBrowse link
G Gabrb2 gamma-aminobutyric acid type A receptor subunit beta 2 multiple interactions EXP topiramate inhibits the reaction [[gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein co-treated with GABRB2 protein co-treated with GABRG2 protein]] which results in increased transport of Chlorides]; topiramate inhibits the reaction [[gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein co-treated with GABRB2 protein co-treated with GABRG2 protein]] which results in increased transport of Chlorides]; topiramate promotes the reaction [[gamma-Aminobutyric Acid results in increased activity of [GABRA6 protein co-treated with GABRB2 protein co-treated with GABRG2 protein]] which results in increased transport of Chlorides] CTD PMID:11123204 NCBI chr10:26,936,592...27,156,141
Ensembl chr10:26,936,551...27,151,251
JBrowse link
G Gabrg2 gamma-aminobutyric acid type A receptor subunit gamma 2 multiple interactions EXP topiramate inhibits the reaction [[gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein co-treated with GABRB2 protein co-treated with GABRG2 protein]] which results in increased transport of Chlorides]; topiramate inhibits the reaction [[gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein co-treated with GABRB2 protein co-treated with GABRG2 protein]] which results in increased transport of Chlorides]; topiramate promotes the reaction [[gamma-Aminobutyric Acid results in increased activity of [GABRA6 protein co-treated with GABRB2 protein co-treated with GABRG2 protein]] which results in increased transport of Chlorides] CTD PMID:11123204 NCBI chr10:26,376,805...26,463,680
Ensembl chr10:26,374,694...26,464,346
JBrowse link
G Glul glutamate-ammonia ligase decreases activity ISO topiramate results in decreased activity of GLUL protein CTD PMID:10323596 NCBI chr13:65,969,064...66,035,121
Ensembl chr13:66,025,630...66,035,108
JBrowse link
G Gnai2 G protein subunit alpha i2 decreases expression EXP topiramate results in decreased expression of GNAI2 mRNA CTD PMID:16979414 NCBI chr 8:108,288,401...108,309,009
Ensembl chr 8:108,288,401...108,308,979
JBrowse link
G Got2 glutamic-oxaloacetic transaminase 2 increases expression EXP topiramate results in increased expression of GOT2 mRNA CTD PMID:16979414 NCBI chr19:9,174,304...9,199,995
Ensembl chr19:9,174,311...9,199,994
JBrowse link
G Gpam glycerol-3-phosphate acyltransferase, mitochondrial decreases expression EXP topiramate results in decreased expression of GPAM mRNA CTD PMID:16979414 NCBI chr 1:254,106,323...254,170,755
Ensembl chr 1:254,106,331...254,142,639
JBrowse link
G Gpd2 glycerol-3-phosphate dehydrogenase 2 increases expression EXP topiramate results in increased expression of GPD2 mRNA CTD PMID:16979414 NCBI chr 3:41,800,552...41,937,729
Ensembl chr 3:41,801,930...41,936,901
JBrowse link
G Gria2 glutamate ionotropic receptor AMPA type subunit 2 multiple interactions EXP topiramate inhibits the reaction [3-nitropropionic acid results in decreased expression of GRIA2 mRNA] CTD PMID:29753867 NCBI chr 2:165,949,379...166,069,510
Ensembl chr 2:165,947,521...166,069,510
JBrowse link
G Grik1 glutamate ionotropic receptor kainate type subunit 1 affects response to substance
affects binding
ISO
EXP
GRIK1 gene SNP affects the susceptibility to topiramate
topiramate binds to Grik1 protein
CTD
RGD
PMID:19331489 PMID:12904467 RGD:731146 NCBI chr11:27,169,739...27,571,131
Ensembl chr11:27,169,740...27,570,645
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions EXP topiramate inhibits the reaction [3-nitropropionic acid results in decreased phosphorylation of GSK3B protein] CTD PMID:29753867 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
JBrowse link
G Gtf2a2 general transcription factor 2A subunit 2 increases expression EXP topiramate results in increased expression of GTF2A2 mRNA CTD PMID:16979414 NCBI chr 8:70,662,395...70,675,576
Ensembl chr 8:70,662,428...70,675,569
JBrowse link
G Gyg1 glycogenin 1 decreases expression EXP topiramate results in decreased expression of GYG1 mRNA CTD PMID:16979414 NCBI chr 2:102,611,888...102,653,916
Ensembl chr 2:102,598,496...102,653,797
JBrowse link
G Hmgcs1 3-hydroxy-3-methylglutaryl-CoA synthase 1 increases expression EXP topiramate results in increased expression of HMGCS1 mRNA CTD PMID:16979414 NCBI chr 2:51,649,368...51,667,100
Ensembl chr 2:51,649,497...51,667,100
JBrowse link
G Hsd3b2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 decreases activity ISO topiramate results in decreased activity of HSD3B2 protein CTD PMID:15730543 NCBI chr 2:186,095,897...186,105,354
Ensembl chr 2:186,095,897...186,101,852
JBrowse link
G Idi1 isopentenyl-diphosphate delta isomerase 1 increases expression EXP topiramate results in increased expression of IDI1 mRNA CTD PMID:16979414 NCBI chr17:61,629,592...61,637,357
Ensembl chr17:61,629,594...61,637,357
JBrowse link
G Ifi30 IFI30, lysosomal thiol reductase multiple interactions EXP [topiramate co-treated with Trinitrobenzenesulfonic Acid] results in decreased expression of IFI30 mRNA CTD PMID:21849664 NCBI chr16:18,675,651...18,679,857
Ensembl chr16:18,675,613...18,681,175
JBrowse link
G Igf1 insulin-like growth factor 1 decreases expression EXP topiramate results in decreased expression of IGF1 mRNA CTD PMID:16979414 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296
JBrowse link
G Itpr1 inositol 1,4,5-trisphosphate receptor, type 1 increases expression EXP topiramate results in increased expression of ITPR1 mRNA CTD PMID:16979414 NCBI chr 4:141,187,377...141,554,240
Ensembl chr 4:141,187,418...141,510,491
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO topiramate results in decreased activity of KCNH2 protein CTD PMID:15716081 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
JBrowse link
G Me1 malic enzyme 1 decreases expression EXP topiramate results in decreased expression of ME1 mRNA CTD PMID:16979414 NCBI chr 8:87,549,043...87,660,251
Ensembl chr 8:87,549,043...87,660,304
JBrowse link
G Mvd mevalonate diphosphate decarboxylase increases expression EXP topiramate results in increased expression of MVD mRNA CTD PMID:16979414 NCBI chr19:50,496,366...50,506,389
Ensembl chr19:50,496,367...50,507,971
JBrowse link
G Nos2 nitric oxide synthase 2 increases expression EXP topiramate results in increased expression of NOS2 protein CTD PMID:14511393 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Npy neuropeptide Y increases expression EXP topiramate results in increased expression of NPY protein CTD PMID:17572454 NCBI chr 4:78,881,294...78,888,495
Ensembl chr 4:78,881,264...78,888,495
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity ISO topiramate results in increased activity of NR1I2 protein CTD PMID:14636322 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
JBrowse link
G Nr2f2 nuclear receptor subfamily 2, group F, member 2 decreases expression EXP topiramate results in decreased expression of NR2F2 mRNA CTD PMID:16979414 NCBI chr 1:124,008,282...124,022,521
Ensembl chr 1:124,009,181...124,022,031
JBrowse link
G Nr4a2 nuclear receptor subfamily 4, group A, member 2 decreases expression EXP topiramate results in decreased expression of NR4A2 mRNA CTD PMID:16979414 NCBI chr 3:41,689,847...41,707,036
Ensembl chr 3:41,689,851...41,697,877
JBrowse link
G Pde4b phosphodiesterase 4B decreases expression EXP topiramate results in decreased expression of PDE4B mRNA CTD PMID:16979414 NCBI chr 5:116,799,827...117,367,707
Ensembl chr 5:116,799,971...117,367,696
JBrowse link
G Pdk4 pyruvate dehydrogenase kinase 4 decreases expression EXP topiramate results in decreased expression of PDK4 mRNA CTD PMID:16979414 NCBI chr 4:33,591,796...33,601,798
Ensembl chr 4:33,589,799...33,601,850
JBrowse link
G Pick1 protein interacting with PRKCA 1 multiple interactions EXP topiramate inhibits the reaction [3-nitropropionic acid results in increased expression of PICK1 protein] CTD PMID:29753867 NCBI chr 7:110,796,623...110,816,850
Ensembl chr 7:110,797,117...110,816,848
JBrowse link
G Plcd4 phospholipase C, delta 4 decreases expression EXP topiramate results in decreased expression of PLCD4 mRNA CTD PMID:16979414 NCBI chr 9:76,115,523...76,158,602
Ensembl chr 9:76,117,168...76,142,453
JBrowse link
G Pld1 phospholipase D1 increases expression EXP topiramate results in increased expression of PLD1 mRNA CTD PMID:16979414 NCBI chr 2:110,849,205...111,047,692
Ensembl chr 2:110,893,608...111,047,692
JBrowse link
G Ppp5c protein phosphatase 5, catalytic subunit increases expression EXP topiramate results in increased expression of PPP5C mRNA CTD PMID:16979414 NCBI chr 1:77,690,203...77,714,507
Ensembl chr 1:77,690,208...77,714,456
JBrowse link
G Prkag1 protein kinase AMP-activated non-catalytic subunit gamma 1 decreases expression EXP topiramate results in decreased expression of PRKAG1 mRNA CTD PMID:16979414 NCBI chr 7:129,963,105...129,980,532
Ensembl chr 7:129,963,105...129,980,561
JBrowse link
G Prkar2b protein kinase cAMP-dependent type II regulatory subunit beta decreases expression EXP topiramate results in decreased expression of PRKAR2B mRNA CTD PMID:16979414 NCBI chr 6:48,563,659...48,653,933
Ensembl chr 6:48,563,662...48,653,933
JBrowse link
G RT1-DMb RT1 class II, locus DMb affects expression ISO topiramate affects the expression of HLA-DMB mRNA CTD PMID:25811541 NCBI chr20:4,693,102...4,700,340
Ensembl chr20:4,693,103...4,700,340
JBrowse link
G Scd stearoyl-CoA desaturase decreases expression EXP topiramate results in decreased expression of SCD1 mRNA CTD PMID:16979414 NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562
JBrowse link
G Slc16a1 solute carrier family 16 member 1 increases expression EXP topiramate results in increased expression of SLC16A1 mRNA CTD PMID:16979414 NCBI chr 2:192,123,755...192,144,617
Ensembl chr 2:192,124,289...192,144,611
JBrowse link
G Slc37a4 solute carrier family 37 member 4 decreases expression EXP topiramate results in decreased expression of SLC37A4 mRNA CTD PMID:16979414 NCBI chr 8:44,723,216...44,729,301
Ensembl chr 8:44,723,339...44,729,301
JBrowse link
G Slc47a1 solute carrier family 47 member 1 multiple interactions ISO topiramate affects the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr10:46,034,115...46,088,617
Ensembl chr10:46,034,122...46,087,637
JBrowse link
G Slc6a6 solute carrier family 6 member 6 decreases expression EXP topiramate results in decreased expression of SLC6A6 mRNA CTD PMID:16979414 NCBI chr 4:124,195,186...124,268,880
Ensembl chr 4:124,195,218...124,268,875
JBrowse link
G Slc7a1 solute carrier family 7 member 1 decreases expression EXP topiramate results in decreased expression of SLC7A1 mRNA CTD PMID:16979414 NCBI chr12:6,628,214...6,703,849
Ensembl chr12:6,628,007...6,703,849
JBrowse link
G Sqle squalene epoxidase decreases expression EXP topiramate results in decreased expression of SQLE mRNA CTD PMID:16979414 NCBI chr 7:90,867,973...90,883,623
Ensembl chr 7:90,868,011...90,883,618
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 increases expression EXP topiramate results in increased expression of SREBF1 mRNA CTD PMID:16979414 NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650
JBrowse link
G Th tyrosine hydroxylase affects expression
increases expression
ISO topiramate affects the expression of TH mRNA
topiramate results in increased expression of TH mRNA
CTD PMID:22017514 PMID:22489711 NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767
JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 multiple interactions EXP topiramate inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of TRPV1 mRNA] CTD PMID:21849664 NCBI chr10:57,851,428...57,876,513
Ensembl chr10:57,851,428...57,876,513
JBrowse link
G Ucp3 uncoupling protein 3 decreases expression EXP topiramate results in decreased expression of UCP3 mRNA CTD PMID:16979414 NCBI chr 1:154,815,777...154,828,764
Ensembl chr 1:154,815,777...154,828,762
JBrowse link
G Ugt2b7 UDP glucuronosyltransferase family 2 member B7 affects response to substance ISO UGT2B7 gene SNP affects the susceptibility to topiramate CTD PMID:18686368 NCBI chr14:20,896,682...20,919,604
Ensembl chr14:20,896,682...20,919,604
JBrowse link
xylulose term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dcxr dicarbonyl and L-xylulose reductase multiple interactions
increases metabolic processing
ISO [DCXR protein co-treated with NAD] results in increased reduction of Xylulose; [DCXR protein co-treated with NADP] results in increased reduction of Xylulose; [DCXR protein results in increased metabolism of Xylulose] which results in increased chemical synthesis of Xylitol CTD PMID:28595002 NCBI chr10:106,006,404...106,008,294 JBrowse link

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  CHEBI ontology 19800
    chemical entity 19800
      atom 19799
        nonmetal atom 19686
          oxygen atom 19423
            oxygen molecular entity 19423
              organooxygen compound 18998
                carbohydrates and carbohydrate derivatives 12342
                  carbohydrate 12342
                    monosaccharide 4306
                      ketose 410
                        ketoheptose + 1
                        ketohexose + 373
                        ketooctose + 0
                        ketopentose + 2
                        ketose derivative + 3
                        ketotetrose + 0
                        ketotriose + 57
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  CHEBI ontology 19800
    subatomic particle 19799
      composite particle 19799
        hadron 19799
          baryon 19799
            nucleon 19799
              atomic nucleus 19799
                atom 19799
                  main group element atom 19698
                    p-block element atom 19698
                      carbon group element atom 19619
                        carbon atom 19609
                          organic molecular entity 19609
                            heteroorganic entity 19278
                              organochalcogen compound 19052
                                organooxygen compound 18998
                                  carbohydrates and carbohydrate derivatives 12342
                                    carbohydrate 12342
                                      monosaccharide 4306
                                        ketose 410
                                          ketoheptose + 1
                                          ketohexose + 373
                                          ketooctose + 0
                                          ketopentose + 2
                                          ketose derivative + 3
                                          ketotetrose + 0
                                          ketotriose + 57
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