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G |
Akr1b8 |
aldo-keto reductase family 1, member B8 |
multiple interactions |
EXP |
[AKR1B8 protein co-treated with NADP] affects the reduction of 3-deoxyglucosone |
CTD |
PMID:18845131 |
|
NCBI chr 4:61,772,064...61,784,637
Ensembl chr 4:61,771,970...61,828,657
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G |
Gapdh |
glyceraldehyde-3-phosphate dehydrogenase |
multiple interactions |
EXP |
[GAPDH protein co-treated with fructose-1,6-diphosphate co-treated with NAD] results in increased chemical synthesis of sodium arsenite; [GAPDH protein co-treated with fructose-1,6-diphosphate co-treated with NAD] results in increased reduction of sodium arsenate analog; heptelidic acid inhibits the reaction [[GAPDH protein co-treated with fructose-1,6-diphosphate co-treated with NAD] results in increased reduction of sodium arsenate analog] |
CTD |
PMID:15788719 |
|
NCBI chr 4:157,676,336...157,680,322
Ensembl chr 4:157,676,595...157,679,962
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G |
Idh2 |
isocitrate dehydrogenase (NADP(+)) 2 |
increases abundance multiple interactions |
ISO |
IDH2 protein mutant form results in increased abundance of fructose-1,6-diphosphate Triazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of fructose-1,6-diphosphate] |
CTD |
PMID:27469509 |
|
NCBI chr 1:141,874,354...141,893,674
Ensembl chr 1:141,866,283...141,893,705
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G |
Mapk1 |
mitogen activated protein kinase 1 |
multiple interactions |
ISO |
fructose-1,6-diphosphate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein] |
CTD |
PMID:22227475 |
|
NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
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G |
Mapk3 |
mitogen activated protein kinase 3 |
multiple interactions |
ISO |
fructose-1,6-diphosphate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein] |
CTD |
PMID:22227475 |
|
NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
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G |
Nos2 |
nitric oxide synthase 2 |
multiple interactions decreases degradation |
ISO |
fructose-1,6-diphosphate inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; fructose-1,6-diphosphate inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] fructose-1,6-diphosphate results in decreased degradation of NOS2 mRNA |
CTD |
PMID:22227475 |
|
NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
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G |
Pfkm |
phosphofructokinase, muscle |
multiple interactions |
ISO |
fructose 2,6-diphosphate inhibits the reaction [resveratrol results in decreased activity of PFKM protein] |
CTD |
PMID:23454376 |
|
NCBI chr 7:139,702,066...139,722,132
Ensembl chr 7:139,685,573...139,722,132
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G |
Gapdh |
glyceraldehyde-3-phosphate dehydrogenase |
multiple interactions |
EXP |
[GAPDH protein co-treated with fructose-1,6-diphosphate co-treated with NAD] results in increased chemical synthesis of sodium arsenite; [GAPDH protein co-treated with fructose-1,6-diphosphate co-treated with NAD] results in increased reduction of sodium arsenate analog; heptelidic acid inhibits the reaction [[GAPDH protein co-treated with fructose-1,6-diphosphate co-treated with NAD] results in increased reduction of sodium arsenate analog] |
CTD |
PMID:15788719 |
|
NCBI chr 4:157,676,336...157,680,322
Ensembl chr 4:157,676,595...157,679,962
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|
G |
Idh2 |
isocitrate dehydrogenase (NADP(+)) 2 |
increases abundance multiple interactions |
ISO |
IDH2 protein mutant form results in increased abundance of fructose-1,6-diphosphate Triazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of fructose-1,6-diphosphate] |
CTD |
PMID:27469509 |
|
NCBI chr 1:141,874,354...141,893,674
Ensembl chr 1:141,866,283...141,893,705
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G |
Mapk1 |
mitogen activated protein kinase 1 |
multiple interactions |
ISO |
fructose-1,6-diphosphate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein] |
CTD |
PMID:22227475 |
|
NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
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G |
Mapk3 |
mitogen activated protein kinase 3 |
multiple interactions |
ISO |
fructose-1,6-diphosphate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein] |
CTD |
PMID:22227475 |
|
NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
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G |
Nos2 |
nitric oxide synthase 2 |
multiple interactions decreases degradation |
ISO |
fructose-1,6-diphosphate inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; fructose-1,6-diphosphate inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] fructose-1,6-diphosphate results in decreased degradation of NOS2 mRNA |
CTD |
PMID:22227475 |
|
NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
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G |
A1bg |
alpha-1-B glycoprotein |
multiple interactions |
EXP |
[Fructose co-treated with bisphenol A] results in decreased expression of A1BG protein |
CTD |
PMID:26930160 |
|
NCBI chr 7:102,294,805...102,298,522
Ensembl chr 7:102,294,797...102,298,522
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G |
Abca1 |
ATP binding cassette subfamily A member 1 |
multiple interactions increases expression |
EXP |
Tea inhibits the reaction [Fructose results in increased expression of ABCA1 mRNA] |
CTD |
PMID:19193814 |
|
NCBI chr 5:69,857,717...69,983,042
Ensembl chr 5:69,857,771...69,983,015
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G |
Abcc2 |
ATP binding cassette subfamily C member 2 |
multiple interactions decreases expression |
EXP |
Ascorbic Acid inhibits the reaction [Fructose results in decreased expression of ABCC2 mRNA]; Ascorbic Acid inhibits the reaction [Fructose results in decreased expression of ABCC2 protein]; geraniol inhibits the reaction [Fructose results in decreased expression of ABCC2 mRNA]; geraniol inhibits the reaction [Fructose results in decreased expression of ABCC2 protein] Fructose results in decreased expression of ABCC2 mRNA; Fructose results in decreased expression of ABCC2 protein |
CTD |
PMID:31005848 |
|
NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252
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G |
Acaca |
acetyl-CoA carboxylase alpha |
multiple interactions decreases phosphorylation increases expression |
ISO EXP |
FGF21 gene mutant form inhibits the reaction [Fructose results in increased expression of ACACA mRNA]; Phenylbutyrates inhibits the reaction [Fructose results in increased expression of ACACA mRNA]; SCD1 gene mutant form inhibits the reaction [Fructose results in increased expression of ACACA mRNA]; Triolein inhibits the reaction [SCD1 gene mutant form inhibits the reaction [Fructose results in increased expression of ACACA mRNA]]; Triolein promotes the reaction [Fructose results in increased expression of ACACA mRNA] Fructose results in decreased phosphorylation of ACACA protein [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in decreased activity of SIRT1 protein] inhibits the reaction [Fructose results in increased expression of ACACA mRNA]; [Niacinamide results in decreased activity of SIRT1 protein] inhibits the reaction [Fructose results in increased expression of ACACA mRNA]; Fructose inhibits the reaction [Streptozocin results in decreased activity of ACACA protein]; Fructose inhibits the reaction [Streptozocin results in decreased expression of ACACA mRNA]; Rotenone inhibits the reaction [Fructose results in increased expression of ACACA mRNA] |
CTD |
PMID:1973097 PMID:15066988 PMID:21212096 PMID:22698815 PMID:28123933 PMID:31672515 |
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NCBI chr10:71,519,392...71,719,910
Ensembl chr10:71,536,533...71,719,910
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G |
Acacb |
acetyl-CoA carboxylase beta |
decreases expression increases expression multiple interactions |
ISO EXP |
Fructose results in decreased expression of ACACB mRNA Fructose results in increased expression of ACACB mRNA FGF21 gene mutant form inhibits the reaction [Fructose results in increased expression of ACACB mRNA] |
CTD |
PMID:18063403 PMID:19053045 PMID:28123933 |
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NCBI chr12:48,127,149...48,238,969
Ensembl chr12:48,127,149...48,238,887
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G |
Acadl |
acyl-CoA dehydrogenase, long chain |
multiple interactions |
EXP |
[Fructose co-treated with Copper deficiency] results in decreased expression of ACADL mRNA |
CTD |
PMID:25813056 |
|
NCBI chr 9:73,833,368...73,871,857
Ensembl chr 9:73,833,388...73,871,888
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G |
Acadm |
acyl-CoA dehydrogenase medium chain |
multiple interactions |
EXP |
[Fructose co-treated with Copper deficiency] results in decreased expression of ACADM mRNA |
CTD |
PMID:25813056 |
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NCBI chr 2:260,124,418...260,148,589
Ensembl chr 2:260,124,418...260,148,589
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G |
Acads |
acyl-CoA dehydrogenase short chain |
multiple interactions |
EXP |
[Fructose co-treated with bisphenol A] results in decreased expression of ACADS protein |
CTD |
PMID:26930160 |
|
NCBI chr12:47,254,503...47,263,747
Ensembl chr12:47,254,484...47,263,747
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G |
Acadvl |
acyl-CoA dehydrogenase, very long chain |
multiple interactions |
EXP |
[Fructose co-treated with bisphenol A] results in increased expression of ACADVL protein; [Fructose co-treated with Copper deficiency] results in decreased expression of ACADVL mRNA |
CTD |
PMID:25813056 PMID:26930160 |
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NCBI chr10:56,619,321...56,624,468
Ensembl chr10:56,619,303...56,624,526
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G |
Ace |
angiotensin I converting enzyme |
increases expression multiple interactions |
EXP |
Fructose results in increased expression of ACE mRNA [bisphenol A co-treated with Fructose] results in increased expression of ACE mRNA; APLN protein modified form inhibits the reaction [Fructose results in increased expression of ACE mRNA] |
CTD |
PMID:17587757 PMID:27622962 PMID:30710622 |
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NCBI chr10:94,170,766...94,213,831
Ensembl chr10:94,170,766...94,187,822
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G |
Acly |
ATP citrate lyase |
increases expression |
EXP |
Fructose results in increased expression of ACLY mRNA |
CTD |
PMID:1396700 |
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NCBI chr10:88,392,248...88,442,845
Ensembl chr10:88,392,248...88,442,845
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G |
Acox1 |
acyl-CoA oxidase 1 |
multiple interactions decreases expression |
EXP |
Atorvastatin inhibits the reaction [Fructose results in decreased expression of ACOX1 mRNA] |
CTD |
PMID:21122807 |
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NCBI chr10:104,724,534...104,748,003
Ensembl chr10:104,722,958...104,748,050
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G |
Acsf2 |
acyl-CoA synthetase family member 2 |
multiple interactions |
EXP |
[Fructose co-treated with bisphenol A] results in increased expression of ACSF2 protein |
CTD |
PMID:26930160 |
|
NCBI chr10:82,284,719...82,326,771
Ensembl chr10:82,284,720...82,326,771
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G |
Acta2 |
actin alpha 2, smooth muscle |
increases expression multiple interactions |
EXP |
Fructose results in increased expression of ACTA2 protein 2-(3-(4-ethoxybenzyl)-4-chlorophenyl)-6-hydroxymethyltetrahydro-2H-pyran-3,4,5-triol inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of ACTA2 protein]; [Streptozocin co-treated with Fructose] results in increased expression of ACTA2 protein; Genistein inhibits the reaction [Fructose results in increased expression of ACTA2 protein]; Metformin promotes the reaction [2-(3-(4-ethoxybenzyl)-4-chlorophenyl)-6-hydroxymethyltetrahydro-2H-pyran-3,4,5-triol inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of ACTA2 protein]] |
CTD |
PMID:21704028 PMID:30551545 |
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NCBI chr 1:252,537,614...252,550,394
Ensembl chr 1:252,537,615...252,550,394
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G |
Ada |
adenosine deaminase |
multiple interactions increases activity |
EXP |
Glutamine inhibits the reaction [Fructose results in increased activity of ADA protein] |
CTD |
PMID:31233715 |
|
NCBI chr 3:160,115,840...160,139,947
Ensembl chr 3:160,115,842...160,139,947
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G |
Adgre1 |
adhesion G protein-coupled receptor E1 |
multiple interactions increases expression |
EXP ISO |
[gadolinium chloride co-treated with Fructose co-treated with Copper deficiency] results in decreased expression of ADGRE1 mRNA Fructose results in increased expression of ADGRE1 protein Ethanol promotes the reaction [Fructose results in increased expression of ADGRE1 protein]; Fructose promotes the reaction [Ethanol results in increased expression of ADGRE1 mRNA]; Fructose promotes the reaction [Ethanol results in increased expression of ADGRE1 protein] |
CTD |
PMID:25813056 PMID:26858005 |
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NCBI chr 9:9,431,888...9,585,883
Ensembl chr 9:9,431,860...9,585,865
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G |
Adipoq |
adiponectin, C1Q and collagen domain containing |
multiple interactions decreases secretion increases secretion decreases expression increases expression |
EXP ISO |
[Particulate Matter co-treated with Ozone] promotes the reaction [Fructose results in decreased expression of ADIPOQ mRNA]; Curcumin inhibits the reaction [Fructose results in decreased expression of ADIPOQ protein]; geraniol inhibits the reaction [Fructose results in decreased secretion of ADIPOQ protein]; Metformin inhibits the reaction [Fructose results in decreased expression of ADIPOQ protein]; Ozone promotes the reaction [Fructose results in decreased expression of ADIPOQ mRNA]; Particulate Matter promotes the reaction [Fructose results in decreased expression of ADIPOQ mRNA]; Pioglitazone inhibits the reaction [Fructose results in decreased secretion of ADIPOQ protein]; Resveratrol inhibits the reaction [Fructose results in decreased expression of ADIPOQ mRNA]; Resveratrol inhibits the reaction [Fructose results in decreased expression of ADIPOQ protein]; sapropterin inhibits the reaction [Fructose results in decreased expression of ADIPOQ mRNA]; sapropterin inhibits the reaction [Fructose results in decreased expression of ADIPOQ protein] Fructose results in increased secretion of ADIPOQ protein Fructose results in decreased expression of ADIPOQ mRNA; Fructose results in decreased expression of ADIPOQ protein Fructose results in increased expression of ADIPOQ mRNA; Fructose results in increased expression of ADIPOQ protein |
CTD |
PMID:17098227 PMID:19165636 PMID:21122807 PMID:23016136 PMID:23968387 PMID:25108154 PMID:25679220 PMID:26713546 PMID:26973390 PMID:28257781 |
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NCBI chr11:81,330,845...81,344,488
Ensembl chr11:81,330,293...81,344,488
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G |
Adipor2 |
adiponectin receptor 2 |
decreases expression |
ISO |
Fructose results in decreased expression of ADIPOR2 protein |
CTD |
PMID:28257781 |
|
NCBI chr 4:151,412,135...151,480,108
Ensembl chr 4:151,414,684...151,428,894
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G |
Ager |
advanced glycosylation end product-specific receptor |
increases expression multiple interactions |
EXP |
Fructose results in increased expression of AGER protein Genistein inhibits the reaction [Fructose results in increased expression of AGER protein]; geraniol inhibits the reaction [Fructose results in increased expression of AGER protein]; Pioglitazone inhibits the reaction [Fructose results in increased expression of AGER protein] |
CTD |
PMID:21704028 PMID:25679220 |
|
NCBI chr20:4,363,152...4,366,079
Ensembl chr20:4,363,152...4,366,079
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G |
Agt |
angiotensinogen |
increases expression multiple interactions |
EXP ISO |
Fructose results in increased expression of AGT mRNA; Fructose results in increased expression of AGT protein; Fructose results in increased expression of AGT protein modified form APLN protein modified form inhibits the reaction [Fructose results in increased expression of AGT mRNA]; APLN protein modified form inhibits the reaction [Fructose results in increased expression of AGT protein modified form]; APLN protein modified form inhibits the reaction [Fructose results in increased expression of AGT protein] |
CTD |
PMID:11741341 PMID:16843071 PMID:17587757 PMID:18360027 PMID:30710622 |
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NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433
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G |
Agtr1a |
angiotensin II receptor, type 1a |
multiple interactions increases expression |
EXP ISO |
APLN protein modified form inhibits the reaction [Fructose results in increased expression of AGTR1A mRNA]; INS protein inhibits the reaction [Fructose results in increased expression of AGTR1A mRNA] Fructose results in increased expression of AGTR1 mRNA |
CTD |
PMID:16843071 PMID:17587757 PMID:18360027 PMID:30710622 PMID:31655124 |
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NCBI chr17:35,907,102...35,958,136
Ensembl chr17:35,907,108...35,958,077
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G |
Agtr1b |
angiotensin II receptor, type 1b |
increases expression multiple interactions |
EXP |
Fructose results in increased expression of AGTR1B mRNA KLK1 protein inhibits the reaction [Fructose results in increased expression of AGTR1B mRNA] |
CTD |
PMID:14568997 |
|
NCBI chr 2:105,149,020...105,224,335
Ensembl chr 2:105,149,020...105,224,295
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G |
Agtr2 |
angiotensin II receptor, type 2 |
multiple interactions increases expression |
EXP |
APLN protein modified form inhibits the reaction [Fructose results in increased expression of AGTR2 mRNA] |
CTD |
PMID:30710622 |
|
NCBI chr X:119,389,480...119,393,845
Ensembl chr X:119,390,013...119,393,842
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G |
Ahr |
aryl hydrocarbon receptor |
multiple interactions |
ISO |
[Dietary Fats co-treated with Fructose] results in increased expression of AHR mRNA; AHR protein results in increased susceptibility to [Dietary Fats co-treated with Fructose]; NR0B2 protein inhibits the reaction [AHR protein results in increased susceptibility to [Dietary Fats co-treated with Fructose]]; PEMT protein promotes the reaction [AHR protein results in increased susceptibility to [Dietary Fats co-treated with Fructose]] |
CTD |
PMID:29416063 |
|
NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
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G |
Akr1b1 |
aldo-keto reductase family 1 member B |
multiple interactions |
EXP |
[Fructose co-treated with bisphenol A] results in increased expression of AKR1B1 protein |
CTD |
PMID:26930160 |
|
NCBI chr 4:61,706,866...61,720,959
Ensembl chr 4:61,706,864...61,720,956
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G |
Akt1 |
AKT serine/threonine kinase 1 |
decreases phosphorylation increases phosphorylation multiple interactions |
EXP |
Fructose results in decreased phosphorylation of AKT1 protein Fructose results in increased phosphorylation of AKT1 protein [2-(3-(4-ethoxybenzyl)-4-chlorophenyl)-6-hydroxymethyltetrahydro-2H-pyran-3,4,5-triol co-treated with Atorvastatin] inhibits the reaction [[Fructose co-treated with Dietary Fats] results in decreased expression of AKT1 protein]; [Fructose co-treated with Dietary Fats] results in decreased expression of and results in decreased phosphorylation of AKT1 protein; [Fructose co-treated with Oleanolic Acid] results in increased expression of AKT1 mRNA; NOS3 protein inhibits the reaction [Fructose results in decreased phosphorylation of AKT1 protein]; Quercetin inhibits the reaction [Fructose results in decreased phosphorylation of AKT1 protein]; Quercetin inhibits the reaction [Fructose results in increased phosphorylation of AKT1 protein]; Rutin inhibits the reaction [Fructose results in decreased phosphorylation of AKT1 protein] |
CTD |
PMID:18497449 PMID:19008412 PMID:22426011 PMID:23533474 PMID:24704288 PMID:32259528 |
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NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
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G |
Aldob |
aldolase, fructose-bisphosphate B |
increases expression multiple interactions |
ISO EXP |
Fructose results in increased expression of ALDOB mRNA FGF21 gene mutant form inhibits the reaction [Fructose results in increased expression of ALDOB mRNA] |
CTD |
PMID:15066988 PMID:18346472 PMID:28123933 |
|
NCBI chr 5:64,805,772...64,818,813
Ensembl chr 5:64,805,773...64,818,824
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G |
Alox5 |
arachidonate 5-lipoxygenase |
increases expression |
ISO |
Fructose results in increased expression of ALOX5 mRNA |
CTD |
PMID:31655124 |
|
NCBI chr 4:148,398,004...148,446,308
Ensembl chr 4:148,398,892...148,446,303
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G |
Apaf1 |
apoptotic peptidase activating factor 1 |
multiple interactions |
ISO |
[Fructose co-treated with Dietary Fats] results in increased expression of APAF1 mRNA; troxerutin inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of APAF1 mRNA] |
CTD |
PMID:28916335 |
|
NCBI chr 7:31,699,309...31,784,192
Ensembl chr 7:31,699,885...31,784,192
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G |
Apln |
apelin |
multiple interactions |
EXP |
APLN protein modified form inhibits the reaction [Fructose results in decreased activity of CAT protein]; APLN protein modified form inhibits the reaction [Fructose results in decreased expression of APLNR mRNA]; APLN protein modified form inhibits the reaction [Fructose results in increased expression of ACE mRNA]; APLN protein modified form inhibits the reaction [Fructose results in increased expression of AGT mRNA]; APLN protein modified form inhibits the reaction [Fructose results in increased expression of AGT protein modified form]; APLN protein modified form inhibits the reaction [Fructose results in increased expression of AGT protein]; APLN protein modified form inhibits the reaction [Fructose results in increased expression of AGTR1A mRNA]; APLN protein modified form inhibits the reaction [Fructose results in increased expression of AGTR2 mRNA] |
CTD |
PMID:30710622 |
|
NCBI chr X:134,856,719...134,866,210
Ensembl chr X:134,856,726...134,866,210
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G |
Aplnr |
apelin receptor |
decreases expression multiple interactions |
EXP |
Fructose results in decreased expression of APLNR mRNA APLN protein modified form inhibits the reaction [Fructose results in decreased expression of APLNR mRNA] |
CTD |
PMID:30710622 |
|
NCBI chr 3:72,540,538...72,544,183
Ensembl chr 3:72,540,538...72,544,182
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G |
Apoa1 |
apolipoprotein A1 |
increases expression multiple interactions decreases expression |
EXP ISO |
Fructose results in increased expression of APOA1 mRNA; Fructose results in increased expression of APOA1 protein Plant Preparations inhibits the reaction [Fructose results in decreased expression of APOA1 protein] [bisphenol A co-treated with Fructose] results in increased expression of APOA1 protein |
CTD |
PMID:9322794 PMID:23142792 PMID:27531227 |
|
NCBI chr 8:50,525,091...50,526,875
Ensembl chr 8:50,525,091...50,526,875
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G |
Apoa4 |
apolipoprotein A4 |
increases expression |
ISO |
Fructose results in increased expression of APOA4 mRNA |
CTD |
PMID:11983814 |
|
NCBI chr 8:50,536,983...50,539,371
Ensembl chr 8:50,537,009...50,539,376
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|
G |
Apob |
apolipoprotein B |
multiple interactions increases expression |
EXP ISO |
[Fructose co-treated with Copper deficiency] results in decreased expression of APOB mRNA; Atorvastatin inhibits the reaction [Fructose results in increased expression of APOB protein]; gadolinium chloride promotes the reaction [[Fructose co-treated with Copper deficiency] results in decreased expression of APOB mRNA] [FGF21 gene mutant form results in increased susceptibility to Fructose] which results in decreased expression of APOB mRNA; Plant Preparations inhibits the reaction [Fructose results in increased expression of APOB protein] Fructose results in increased expression of APOB mRNA; Fructose results in increased expression of APOB protein |
CTD |
PMID:8415773 PMID:12065722 PMID:25813056 PMID:27531227 PMID:28123933 |
|
NCBI chr 6:33,176,826...33,216,381
Ensembl chr 6:33,176,778...33,224,997
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G |
Atf4 |
activating transcription factor 4 |
increases expression |
EXP |
Fructose results in increased expression of ATF4 mRNA |
CTD |
PMID:15150374 |
|
NCBI chr 7:121,480,723...121,482,781
Ensembl chr 7:121,480,723...121,482,772
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G |
Atp1b1 |
ATPase Na+/K+ transporting subunit beta 1 |
decreases expression |
EXP |
Fructose results in decreased expression of ATP1B1 protein |
CTD |
PMID:26930160 |
|
NCBI chr13:82,737,161...82,757,681
Ensembl chr13:82,737,159...82,758,004
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|
G |
Atp2a2 |
ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 |
multiple interactions |
ISO |
[Fructose co-treated with Dietary Fats] results in decreased expression of ATP2A2 mRNA; troxerutin inhibits the reaction [[Fructose co-treated with Dietary Fats] results in decreased expression of ATP2A2 mRNA] |
CTD |
PMID:28916335 |
|
NCBI chr12:39,553,903...39,603,326
Ensembl chr12:39,553,903...39,603,326
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G |
Atp5mf |
ATP synthase membrane subunit f |
multiple interactions increases expression |
EXP |
[Fructose co-treated with bisphenol A] results in decreased expression of ATP5MF protein Fructose results in increased expression of ATP5MF protein |
CTD |
PMID:26930160 |
|
NCBI chr12:11,191,799...11,198,369
Ensembl chr12:11,191,812...11,198,369
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G |
Bax |
BCL2 associated X, apoptosis regulator |
increases expression multiple interactions |
ISO |
Fructose results in increased expression of BAX protein [Fructose co-treated with Dietary Fats] results in increased expression of BAX mRNA; [Fructose co-treated with Dietary Fats] results in increased expression of BAX protein; Plant Preparations inhibits the reaction [Fructose results in increased expression of BAX protein]; troxerutin inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of BAX mRNA]; troxerutin inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of BAX protein] |
CTD |
PMID:27531227 PMID:28916335 |
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NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
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G |
Bcl2 |
BCL2, apoptosis regulator |
decreases expression increases expression multiple interactions |
ISO EXP |
Fructose results in decreased expression of BCL2 protein Fructose results in increased expression of BCL2 mRNA 2-(3-(4-ethoxybenzyl)-4-chlorophenyl)-6-hydroxymethyltetrahydro-2H-pyran-3,4,5-triol inhibits the reaction [[Fructose co-treated with Dietary Fats] results in decreased expression of BCL2 protein]; [Atorvastatin co-treated with 2-(3-(4-ethoxybenzyl)-4-chlorophenyl)-6-hydroxymethyltetrahydro-2H-pyran-3,4,5-triol] inhibits the reaction [[Fructose co-treated with Dietary Fats] results in decreased expression of BCL2 protein]; [Fructose co-treated with Dietary Fats] results in decreased expression of BCL2 protein; Kangen-karyu inhibits the reaction [Fructose results in increased expression of BCL2 protein] [Fructose co-treated with Dietary Fats] results in decreased expression of BCL2 mRNA; [Fructose co-treated with Dietary Fats] results in decreased expression of BCL2 protein; troxerutin inhibits the reaction [[Fructose co-treated with Dietary Fats] results in decreased expression of BCL2 mRNA]; troxerutin inhibits the reaction [[Fructose co-treated with Dietary Fats] results in decreased expression of BCL2 protein] |
CTD |
PMID:17883899 PMID:27531227 PMID:28916335 PMID:31655124 PMID:32259528 |
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NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
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G |
Calca |
calcitonin-related polypeptide alpha |
increases expression |
ISO |
Fructose results in increased expression of CALCA mRNA |
CTD |
PMID:31655124 |
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NCBI chr 1:184,184,018...184,188,922
Ensembl chr 1:184,184,020...184,188,911
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G |
Casp1 |
caspase 1 |
multiple interactions increases expression |
EXP |
Allopurinol inhibits the reaction [Fructose results in increased expression of CASP1 protein modified form]; Allopurinol inhibits the reaction [Fructose results in increased expression of CASP1 protein]; Quercetin inhibits the reaction [Fructose results in increased expression of CASP1 protein modified form]; Quercetin inhibits the reaction [Fructose results in increased expression of CASP1 protein]; Rutin inhibits the reaction [Fructose results in increased expression of CASP1 protein] Fructose results in increased expression of CASP1 protein; Fructose results in increased expression of CASP1 protein modified form |
CTD |
PMID:22426011 PMID:24491314 |
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NCBI chr 8:2,605,743...2,614,637
Ensembl chr 8:2,604,962...2,614,631
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G |
Casp3 |
caspase 3 |
multiple interactions decreases expression increases expression |
ISO EXP |
[Fructose co-treated with Dietary Fats] results in increased expression of CASP3 mRNA; [Fructose co-treated with Dietary Fats] results in increased expression of CASP3 protein; troxerutin inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of CASP3 mRNA]; troxerutin inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of CASP3 protein] Fructose results in decreased expression of CASP3 mRNA imoxin inhibits the reaction [Fructose results in increased expression of CASP3 protein] |
CTD |
PMID:28916335 PMID:29430716 PMID:31655124 |
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NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
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G |
Casp7 |
caspase 7 |
multiple interactions |
EXP |
2-(3-(4-ethoxybenzyl)-4-chlorophenyl)-6-hydroxymethyltetrahydro-2H-pyran-3,4,5-triol inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of CASP7 protein]; 2-(3-(4-ethoxybenzyl)-4-chlorophenyl)-6-hydroxymethyltetrahydro-2H-pyran-3,4,5-triol promotes the reaction [Metformin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of CASP7 protein]]; [Streptozocin co-treated with Fructose] results in increased expression of CASP7 protein; Metformin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of CASP7 protein]; Metformin promotes the reaction [2-(3-(4-ethoxybenzyl)-4-chlorophenyl)-6-hydroxymethyltetrahydro-2H-pyran-3,4,5-triol inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of CASP7 protein]] |
CTD |
PMID:30551545 |
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NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774
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G |
Casp9 |
caspase 9 |
multiple interactions |
ISO |
[Fructose co-treated with Dietary Fats] results in increased expression of CASP9 mRNA; [Fructose co-treated with Dietary Fats] results in increased expression of CASP9 protein; troxerutin inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of CASP9 mRNA]; troxerutin inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of CASP9 protein] |
CTD |
PMID:28916335 |
|
NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
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G |
Cat |
catalase |
decreases expression multiple interactions decreases activity |
EXP ISO |
Fructose results in decreased expression of CAT mRNA; Fructose results in decreased expression of CAT protein [Fructose co-treated with Dietary Fats] results in decreased activity of CAT protein; troxerutin inhibits the reaction [[Fructose co-treated with Dietary Fats] results in decreased activity of CAT protein] [Hydrochlorothiazide co-treated with Fructose] results in decreased activity of CAT protein; APLN protein modified form inhibits the reaction [Fructose results in decreased activity of CAT protein] |
CTD |
PMID:11817707 PMID:20470786 PMID:23707192 PMID:28916335 PMID:30710622 |
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NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
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G |
Cavin3 |
caveolae associated protein 3 |
multiple interactions |
EXP |
[Fructose co-treated with bisphenol A] results in increased expression of CAVIN3 protein |
CTD |
PMID:26930160 |
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NCBI chr 1:170,317,099...170,318,688
Ensembl chr 1:170,317,113...170,318,935
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G |
Ccl2 |
C-C motif chemokine ligand 2 |
multiple interactions increases expression increases secretion |
ISO EXP |
[Fructose co-treated with Uric Acid] results in increased secretion of CCL2 protein; acetovanillone inhibits the reaction [Fructose results in increased secretion of CCL2 protein]; Acetylcysteine inhibits the reaction [Fructose results in increased secretion of CCL2 protein]; Allopurinol inhibits the reaction [[Fructose co-treated with Uric Acid] results in increased secretion of CCL2 protein]; Allopurinol inhibits the reaction [Fructose results in increased secretion of CCL2 protein]; Glucose inhibits the reaction [Fructose results in increased secretion of CCL2 protein]; KHK protein promotes the reaction [Fructose results in increased secretion of CCL2 protein]; Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin inhibits the reaction [Fructose results in increased secretion of CCL2 protein]; Superoxides affects the reaction [Fructose results in increased secretion of CCL2 protein] Fructose results in increased expression of CCL2 mRNA Fructose results in increased expression of CCL2 protein [Dietary Fats co-treated with Fructose] results in increased expression of CCL2 protein; [FGF21 gene mutant form results in increased susceptibility to Fructose] which results in increased expression of CCL2 mRNA; [Fructose co-treated with Ethanol] results in increased expression of CCL2 mRNA; sarpogrelate inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of CCL2 protein] 2-(3-(4-ethoxybenzyl)-4-chlorophenyl)-6-hydroxymethyltetrahydro-2H-pyran-3,4,5-triol inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of and results in increased secretion of CCL2 protein]; [Copper deficiency co-treated with Fructose] results in increased expression of CCL2 protein; [Fructose co-treated with Copper deficiency] results in increased expression of CCL2 protein; [Lipopolysaccharides co-treated with Fructose co-treated with Copper deficiency] results in increased expression of CCL2 protein; [Particulate Matter co-treated with Ozone] promotes the reaction [Fructose results in increased expression of CCL2 mRNA]; [Streptozocin co-treated with Fructose] results in increased expression of and results in increased secretion of CCL2 protein; Acarbose inhibits the reaction [Fructose results in increased expression of CCL2 mRNA]; Acarbose inhibits the reaction [Fructose results in increased expression of CCL2 protein]; Deferiprone inhibits the reaction [[Lipopolysaccharides co-treated with Fructose co-treated with Copper deficiency] results in increased expression of CCL2 protein]; Deferoxamine inhibits the reaction [[Lipopolysaccharides co-treated with Fructose co-treated with Copper deficiency] results in increased expression of CCL2 protein]; Fish Oils inhibits the reaction [Fructose results in increased expression of CCL2 protein]; gadolinium chloride inhibits the reaction [[Fructose co-treated with Copper deficiency] results in increased expression of CCL2 protein]; Metformin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of and results in increased secretion of CCL2 protein]; Ozone promotes the reaction [Fructose results in increased expression of CCL2 mRNA]; Particulate Matter promotes the reaction [Fructose results in increased expression of CCL2 mRNA] Fructose results in increased expression of CCL2 mRNA; Fructose results in increased expression of CCL2 protein |
CTD |
PMID:15752949 PMID:17133782 PMID:19158351 PMID:21781943 PMID:23968387 PMID:25813056 PMID:26824242 PMID:26858005 PMID:28123933 PMID:30551545 PMID:31655124 PMID:31672515 |
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NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
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G |
Ccl3 |
C-C motif chemokine ligand 3 |
multiple interactions |
ISO |
[FGF21 gene mutant form results in increased susceptibility to Fructose] which results in increased expression of CCL3 mRNA |
CTD |
PMID:28123933 |
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NCBI chr10:70,869,516...70,871,066
Ensembl chr10:70,869,513...70,871,066
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G |
Ccn2 |
cellular communication network factor 2 |
multiple interactions increases expression |
EXP |
betanin inhibits the reaction [Fructose results in increased expression of CCN2 protein] |
CTD |
PMID:25559852 |
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NCBI chr 1:21,851,657...21,854,773
Ensembl chr 1:21,851,660...21,854,773
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G |
Cd163 |
CD163 molecule |
multiple interactions |
EXP ISO |
[gadolinium chloride co-treated with Fructose co-treated with Copper deficiency] results in decreased expression of CD163 mRNA [Fructose co-treated with Ethanol] results in increased expression of CD163 mRNA |
CTD |
PMID:25813056 PMID:26858005 |
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NCBI chr 4:156,752,063...156,785,467
Ensembl chr 4:156,752,082...156,785,467
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G |
Cd36 |
CD36 molecule |
decreases expression multiple interactions |
ISO EXP |
Fructose results in decreased expression of CD36 protein 2-(3-(4-ethoxybenzyl)-4-chlorophenyl)-6-hydroxymethyltetrahydro-2H-pyran-3,4,5-triol inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of CD36 protein]; [Atorvastatin co-treated with 2-(3-(4-ethoxybenzyl)-4-chlorophenyl)-6-hydroxymethyltetrahydro-2H-pyran-3,4,5-triol] inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of CD36 protein]; [Fructose co-treated with Dietary Fats] results in increased expression of CD36 protein |
CTD |
PMID:28257781 PMID:32259528 |
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NCBI chr 4:14,150,309...14,191,498
Ensembl chr 4:14,001,761...14,249,749
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G |
Cd68 |
Cd68 molecule |
multiple interactions |
EXP ISO |
[Dietary Fats co-treated with Fructose] results in increased expression of CD68 mRNA; [gadolinium chloride co-treated with Fructose co-treated with Copper deficiency] results in decreased expression of CD68 mRNA; [gadolinium chloride co-treated with Fructose co-treated with Copper deficiency] results in decreased expression of CD68 protein [FGF21 gene mutant form results in increased susceptibility to Fructose] which results in increased expression of CD68 mRNA; [Fructose co-treated with Ethanol] results in increased expression of CD68 mRNA |
CTD |
PMID:19632207 PMID:25813056 PMID:26858005 PMID:28123933 |
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NCBI chr10:56,268,726...56,270,605
Ensembl chr10:56,268,720...56,270,640
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G |
Chrm2 |
cholinergic receptor, muscarinic 2 |
increases expression |
EXP |
Fructose results in increased expression of CHRM2 mRNA; Fructose results in increased expression of CHRM2 protein |
CTD |
PMID:17707055 |
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NCBI chr 4:64,089,028...64,091,090
Ensembl chr 4:64,088,900...64,091,090
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G |
Chrm3 |
cholinergic receptor, muscarinic 3 |
increases expression |
EXP |
Fructose results in increased expression of CHRM3 mRNA; Fructose results in increased expression of CHRM3 protein |
CTD |
PMID:17707055 |
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NCBI chr17:63,990,599...64,463,222
Ensembl chr17:63,990,599...63,994,169
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G |
Chuk |
component of inhibitor of nuclear factor kappa B kinase complex |
increases phosphorylation multiple interactions |
EXP |
Fructose results in increased phosphorylation of CHUK protein Quercetin inhibits the reaction [Fructose results in increased phosphorylation of CHUK protein] |
CTD |
PMID:24491314 |
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NCBI chr 1:263,848,829...263,884,354
Ensembl chr 1:263,848,884...263,885,169
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G |
Cidea |
cell death-inducing DFFA-like effector a |
multiple interactions decreases expression |
EXP |
[Ozone co-treated with Fructose] results in decreased expression of CIDEA mRNA; [Particulate Matter co-treated with Fructose] results in decreased expression of CIDEA mRNA; [Particulate Matter co-treated with Ozone co-treated with Fructose] results in decreased expression of CIDEA mRNA Fructose results in decreased expression of CIDEA mRNA |
CTD |
PMID:23968387 |
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NCBI chr18:63,082,861...63,108,450
Ensembl chr18:63,098,144...63,108,051
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G |
Cnr1 |
cannabinoid receptor 1 |
increases expression multiple interactions |
EXP |
Fructose results in increased expression of CNR1 mRNA [Fructose co-treated with Streptozocin] results in decreased expression of CNR1 mRNA; Ghrelin inhibits the reaction [[Fructose co-treated with Streptozocin] results in decreased expression of CNR1 mRNA] |
CTD |
PMID:18627777 PMID:31468622 |
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NCBI chr 5:49,307,584...49,333,064
Ensembl chr 5:49,311,030...49,333,056
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G |
Coq9 |
coenzyme Q9 |
multiple interactions |
EXP |
[Fructose co-treated with bisphenol A] results in increased expression of COQ9 protein |
CTD |
PMID:26930160 |
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NCBI chr19:10,583,855...10,596,848
Ensembl chr19:10,583,857...10,596,851
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G |
Cp |
ceruloplasmin |
multiple interactions |
EXP |
[Fructose co-treated with Copper deficiency] results in decreased activity of CP protein; Fructose promotes the reaction [Copper deficiency results in decreased expression of CP protein] |
CTD |
PMID:21781943 PMID:25813056 |
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NCBI chr 2:104,744,249...104,803,034
Ensembl chr 2:104,744,461...104,799,853
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G |
Cpt1a |
carnitine palmitoyltransferase 1A |
multiple interactions |
EXP |
[Dietary Fats co-treated with Fructose] results in increased expression of CPT1A mRNA; [Fructose co-treated with Copper deficiency] results in decreased expression of CPT1A mRNA; [Fructose co-treated with Dietary Fats] results in decreased expression of CPT1A protein |
CTD |
PMID:19632207 PMID:25813056 PMID:32259528 |
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NCBI chr 1:218,568,157...218,629,679
Ensembl chr 1:218,569,510...218,629,678
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G |
Creb1 |
cAMP responsive element binding protein 1 |
increases expression multiple interactions |
EXP |
Fructose results in increased expression of CREB1 mRNA; Fructose results in increased expression of CREB1 protein rosiglitazone inhibits the reaction [Fructose results in increased expression of CREB1 mRNA]; rosiglitazone inhibits the reaction [Fructose results in increased expression of CREB1 protein] |
CTD |
PMID:19196556 |
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NCBI chr 9:71,229,753...71,298,994
Ensembl chr 9:71,230,108...71,293,435
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G |
Crp |
C-reactive protein |
multiple interactions increases expression |
EXP ISO |
[Dietary Fats co-treated with Fructose] results in increased expression of CRP mRNA; Curcumin inhibits the reaction [Fructose results in increased expression of CRP protein]; Metformin inhibits the reaction [Fructose results in increased expression of CRP protein]; resveratrol inhibits the reaction [Fructose results in increased expression of CRP protein] |
CTD |
PMID:19632207 PMID:25108154 PMID:26713546 PMID:31672515 |
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NCBI chr13:91,080,448...91,081,358
Ensembl chr13:91,054,974...91,093,713
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G |
Cst3 |
cystatin C |
multiple interactions |
EXP |
[Streptozocin co-treated with Fructose] results in increased expression of CST3 protein; Metformin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of CST3 protein] |
CTD |
PMID:30551545 |
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NCBI chr 3:143,219,671...143,223,544
Ensembl chr 3:143,219,686...143,223,615
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G |
Cx3cl1 |
C-X3-C motif chemokine ligand 1 |
increases expression |
ISO |
Fructose results in increased expression of CX3CL1 mRNA |
CTD |
PMID:31655124 |
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NCBI chr19:10,644,267...10,654,861
Ensembl chr19:10,644,244...10,653,800
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G |
Cybb |
cytochrome b-245 beta chain |
multiple interactions |
EXP |
[Dietary Fats co-treated with Fructose] results in increased expression of CYBB mRNA |
CTD |
PMID:19632207 |
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NCBI chr X:14,578,330...14,610,049
Ensembl chr X:14,578,264...14,612,547
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G |
Cycs |
cytochrome c, somatic |
multiple interactions |
EXP |
[Atorvastatin co-treated with 2-(3-(4-ethoxybenzyl)-4-chlorophenyl)-6-hydroxymethyltetrahydro-2H-pyran-3,4,5-triol] inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of CYCS protein]; [Fructose co-treated with Dietary Fats] results in increased expression of CYCS protein |
CTD |
PMID:32259528 |
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NCBI chr 4:80,331,226...80,333,326
Ensembl chr 4:80,331,227...80,333,326
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G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
multiple interactions |
ISO |
[Dietary Fats co-treated with Fructose] results in increased expression of CYP1A1 mRNA |
CTD |
PMID:26102010 PMID:29416063 |
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NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
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G |
Cyp1a2 |
cytochrome P450, family 1, subfamily a, polypeptide 2 |
multiple interactions |
ISO |
[Dietary Fats co-treated with Fructose] results in increased expression of CYP1A2 mRNA; alpha-Tocopherol inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of CYP1A2 mRNA]; tetrahydrocurcumin inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of CYP1A2 mRNA] |
CTD |
PMID:26102010 |
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NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
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G |
Cyp1b1 |
cytochrome P450, family 1, subfamily b, polypeptide 1 |
multiple interactions |
ISO |
[Dietary Fats co-treated with Fructose] results in increased expression of CYP1B1 mRNA; [Dietary Fats co-treated with Fructose] results in increased expression of CYP1B1 protein; tetrahydrocurcumin inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of CYP1B1 mRNA]; tetrahydrocurcumin inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of CYP1B1 protein] |
CTD |
PMID:26102010 |
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NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722
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G |
Cyp2c79 |
cytochrome P450, family 2, subfamily c, polypeptide 79 |
multiple interactions |
ISO |
[Dietary Fats co-treated with Fructose] results in increased expression of CYP2C29 mRNA; [Dietary Fats co-treated with Fructose] results in increased expression of CYP2C29 protein; alpha-Tocopherol inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of CYP2C29 protein]; tetrahydrocurcumin inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of CYP2C29 mRNA]; tetrahydrocurcumin inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of CYP2C29 protein] |
CTD |
PMID:26102010 |
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NCBI chr 1:147,236,480...147,307,988
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G |
Cyp2e1 |
cytochrome P450, family 2, subfamily e, polypeptide 1 |
decreases expression increases expression multiple interactions |
ISO |
Fructose results in decreased expression of CYP2E1 protein Fructose results in increased expression of CYP2E1 protein Ethanol promotes the reaction [Fructose results in increased expression of CYP2E1 protein] |
CTD |
PMID:26858005 PMID:28257781 |
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NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
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G |
Cyp4a1 |
cytochrome P450, family 4, subfamily a, polypeptide 1 |
multiple interactions |
EXP |
[Fructose co-treated with Copper deficiency] results in decreased expression of CYP4A1 mRNA; gadolinium chloride promotes the reaction [[Fructose co-treated with Copper deficiency] results in decreased expression of CYP4A1 mRNA] |
CTD |
PMID:25813056 |
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NCBI chr 5:134,492,734...134,507,158
Ensembl chr 5:134,492,756...134,507,154
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G |
Ddt |
D-dopachrome tautomerase |
decreases expression multiple interactions |
EXP |
Fructose results in decreased expression of DDT protein [Fructose co-treated with bisphenol A] results in increased expression of DDT protein |
CTD |
PMID:26930160 |
|
NCBI chr20:13,827,153...13,829,624
Ensembl chr20:13,827,132...13,831,588
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G |
Dek |
DEK proto-oncogene |
multiple interactions |
ISO |
DEK protein results in decreased chemical synthesis of and results in decreased secretion of Fructose |
CTD |
PMID:28558019 |
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NCBI chr17:17,965,872...17,987,836
Ensembl chr17:17,965,881...17,987,834
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G |
Dgat1 |
diacylglycerol O-acyltransferase 1 |
multiple interactions |
ISO |
[FGF21 gene mutant form results in increased susceptibility to Fructose] which results in increased expression of DGAT1 mRNA |
CTD |
PMID:28123933 |
|
NCBI chr 7:117,566,363...117,576,735
Ensembl chr 7:117,566,368...117,576,737
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G |
Dgat2 |
diacylglycerol O-acyltransferase 2 |
multiple interactions |
ISO |
[FGF21 gene mutant form results in increased susceptibility to Fructose] which results in decreased expression of DGAT2 mRNA |
CTD |
PMID:28123933 |
|
NCBI chr 1:164,113,459...164,143,818
Ensembl chr 1:164,113,459...164,143,818
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G |
Dld |
dihydrolipoamide dehydrogenase |
multiple interactions |
EXP |
[Fructose co-treated with bisphenol A] results in decreased expression of DLD protein |
CTD |
PMID:26930160 |
|
NCBI chr 6:50,597,677...50,618,694
Ensembl chr 6:50,597,677...50,618,694
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G |
Dpt |
dermatopontin |
multiple interactions decreases expression |
EXP |
[Ozone co-treated with Fructose] results in decreased expression of DPT mRNA; [Particulate Matter co-treated with Fructose] results in decreased expression of DPT mRNA; Fructose affects the reaction [[Ozone co-treated with Particulate Matter] results in decreased expression of DPT mRNA] Fructose results in decreased expression of DPT mRNA |
CTD |
PMID:23968387 |
|
NCBI chr13:83,073,307...83,102,404
Ensembl chr13:83,073,544...83,102,401
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G |
Echs1 |
enoyl-CoA hydratase, short chain 1 |
multiple interactions |
EXP |
[Fructose co-treated with bisphenol A] results in increased expression of ECHS1 protein |
CTD |
PMID:26930160 |
|
NCBI chr 1:212,570,213...212,579,040
Ensembl chr 1:212,570,195...212,579,057 Ensembl chr 1:212,570,195...212,579,057
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G |
Edn1 |
endothelin 1 |
increases response to substance increases expression multiple interactions |
EXP |
Fructose results in increased susceptibility to EDN1 protein Fructose results in increased expression of EDN1 mRNA; Fructose results in increased expression of EDN1 protein modified form KLK1 protein inhibits the reaction [Fructose results in increased expression of EDN1 mRNA]; Metformin inhibits the reaction [Fructose results in increased expression of EDN1 protein]; resveratrol inhibits the reaction [Fructose results in increased expression of EDN1 protein] |
CTD |
PMID:9869011 PMID:11172478 PMID:14568997 PMID:25108154 |
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NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324
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G |
Ednra |
endothelin receptor type A |
multiple interactions increases expression |
EXP ISO |
KLK1 protein inhibits the reaction [Fructose results in increased expression of EDNRA mRNA] |
CTD |
PMID:9869011 PMID:14568997 PMID:31655124 |
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NCBI chr19:33,928,356...33,991,703
Ensembl chr19:33,928,356...33,991,703
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G |
Eef1a2 |
eukaryotic translation elongation factor 1 alpha 2 |
multiple interactions |
EXP |
[Fructose co-treated with bisphenol A] results in decreased expression of EEF1A2 protein |
CTD |
PMID:26930160 |
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NCBI chr 3:176,657,104...176,666,282
Ensembl chr 3:176,657,107...176,666,282
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G |
Egf |
epidermal growth factor |
multiple interactions increases uptake |
EXP |
wortmannin inhibits the reaction [EGF protein results in increased uptake of Fructose] |
CTD |
PMID:15691865 |
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NCBI chr 2:68,820,616...68,895,537
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G |
Eif2ak2 |
eukaryotic translation initiation factor 2-alpha kinase 2 |
increases expression multiple interactions |
EXP |
Fructose results in increased expression of EIF2AK2 protein imoxin inhibits the reaction [Fructose results in increased expression of EIF2AK2 protein] |
CTD |
PMID:29430716 |
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NCBI chr 6:1,428,845...1,466,193
Ensembl chr 6:1,428,834...1,466,201
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G |
Eif2ak3 |
eukaryotic translation initiation factor 2 alpha kinase 3 |
increases phosphorylation multiple interactions |
ISO |
Fructose results in increased phosphorylation of EIF2AK3 protein Phenylbutyrates inhibits the reaction [Fructose results in increased phosphorylation of EIF2AK3 protein] |
CTD |
PMID:22698815 |
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NCBI chr 4:98,648,513...98,709,695
Ensembl chr 4:98,648,545...98,709,694
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G |
Eif2s1 |
eukaryotic translation initiation factor 2 subunit alpha |
increases phosphorylation multiple interactions |
ISO |
Fructose results in increased phosphorylation of EIF2S1 protein Phenylbutyrates inhibits the reaction [Fructose results in increased phosphorylation of EIF2S1 protein] |
CTD |
PMID:22698815 |
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NCBI chr 6:102,048,372...102,073,041
Ensembl chr 6:102,048,372...102,073,041
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G |
Elovl6 |
ELOVL fatty acid elongase 6 |
increases expression |
ISO |
Fructose results in increased expression of ELOVL6 mRNA |
CTD |
PMID:15066988 |
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NCBI chr 2:234,187,490...234,296,124
Ensembl chr 2:234,189,105...234,296,145 Ensembl chr 2:234,189,105...234,296,145
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G |
Entpd2 |
ectonucleoside triphosphate diphosphohydrolase 2 |
decreases expression |
EXP |
Fructose results in decreased expression of ENTPD2 mRNA |
CTD |
PMID:15150374 |
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NCBI chr 3:2,617,795...2,623,818
Ensembl chr 3:2,617,805...2,623,445
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G |
Ezr |
ezrin |
multiple interactions |
EXP |
[Fructose co-treated with bisphenol A] results in increased expression of EZR protein |
CTD |
PMID:26930160 |
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NCBI chr 1:47,287,872...47,331,412
Ensembl chr 1:47,287,874...47,331,412
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G |
F3 |
coagulation factor III, tissue factor |
increases expression |
ISO |
Fructose results in increased expression of F3 mRNA |
CTD |
PMID:31655124 |
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NCBI chr 2:225,310,686...225,322,281
Ensembl chr 2:225,310,624...225,322,272
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G |
Fabp3 |
fatty acid binding protein 3 |
multiple interactions |
EXP |
[Fructose co-treated with bisphenol A] results in increased expression of FABP3 protein |
CTD |
PMID:26930160 |
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NCBI chr 5:148,528,854...148,535,597
Ensembl chr 5:148,528,725...148,535,565
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G |
Fabp4 |
fatty acid binding protein 4 |
multiple interactions |
EXP |
[Fructose co-treated with bisphenol A] results in increased expression of FABP4 protein |
CTD |
PMID:26930160 |
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NCBI chr 2:93,792,666...93,797,267
Ensembl chr 2:93,792,601...93,797,305
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G |
Fas |
Fas cell surface death receptor |
decreases expression |
ISO |
Fructose results in decreased expression of FAS mRNA |
CTD |
PMID:31655124 |
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NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790
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G |
Faslg |
Fas ligand |
increases expression |
ISO |
Fructose results in increased expression of FASLG mRNA |
CTD |
PMID:31655124 |
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NCBI chr13:79,696,811...79,717,581
Ensembl chr13:79,698,445...79,705,705
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G |
Fasn |
fatty acid synthase |
multiple interactions increases expression increases activity |
EXP ISO |
2-(3-(4-ethoxybenzyl)-4-chlorophenyl)-6-hydroxymethyltetrahydro-2H-pyran-3,4,5-triol inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of FASN protein]; [Atorvastatin co-treated with 2-(3-(4-ethoxybenzyl)-4-chlorophenyl)-6-hydroxymethyltetrahydro-2H-pyran-3,4,5-triol] inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of FASN protein]; [Copper deficiency co-treated with Fructose] results in increased expression of FASN protein; [Fenofibrate co-treated with Resveratrol] inhibits the reaction [Fructose results in increased expression of FASN mRNA]; [Fructose co-treated with Dietary Fats] results in increased expression of FASN protein; [gadolinium chloride co-treated with Fructose co-treated with Copper deficiency] results in decreased expression of FASN mRNA; Atorvastatin inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of FASN protein]; Fenofibrate inhibits the reaction [Fructose results in increased expression of FASN mRNA]; Resveratrol inhibits the reaction [Fructose results in increased expression of FASN mRNA]; Rosiglitazone inhibits the reaction [Fructose results in increased expression of FASN mRNA]; Tea inhibits the reaction [Fructose results in increased expression of FASN mRNA] FGF21 gene mutant form inhibits the reaction [Fructose results in increased expression of FASN mRNA]; Phenylbutyrates inhibits the reaction [Fructose results in increased expression of FASN mRNA]; Plant Preparations inhibits the reaction [Fructose results in increased expression of FASN protein]; SCD1 gene mutant form inhibits the reaction [Fructose results in increased expression of FASN mRNA]; Triolein inhibits the reaction [SCD1 gene mutant form inhibits the reaction [Fructose results in increased expression of FASN mRNA]]; Triolein promotes the reaction [Fructose results in increased expression of FASN mRNA] Fructose results in increased expression of FASN mRNA; Fructose results in increased expression of FASN protein Fructose results in increased activity of FASN protein |
CTD |
PMID:8759368 PMID:9566986 PMID:12065722 PMID:15066988 PMID:18346472 PMID:19053045 PMID:19193814 PMID:19196556 PMID:21781943 PMID:22698815 PMID:25813056 PMID:26973390 PMID:27531227 PMID:28123933 PMID:28257781 PMID:32259528 |
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NCBI chr10:109,987,735...110,005,901
Ensembl chr10:109,987,735...110,005,901
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G |
Fbp1 |
fructose-bisphosphatase 1 |
increases activity increases expression multiple interactions |
EXP |
Fructose results in increased activity of FBP1 protein Fructose results in increased expression of FBP1 mRNA Vanadates inhibits the reaction [Fructose results in increased activity of FBP1 protein] |
CTD |
PMID:15150374 PMID:16920846 PMID:18346472 |
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NCBI chr17:396,175...417,480
Ensembl chr17:396,180...417,480
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G |
Fgf21 |
fibroblast growth factor 21 |
multiple interactions increases expression increases response to substance increases secretion |
ISO |
[FGF21 gene mutant form results in increased susceptibility to Fructose] which results in decreased abundance of Blood Glucose; [FGF21 gene mutant form results in increased susceptibility to Fructose] which results in decreased expression of APOB mRNA; [FGF21 gene mutant form results in increased susceptibility to Fructose] which results in decreased expression of DGAT2 mRNA; [FGF21 gene mutant form results in increased susceptibility to Fructose] which results in increased expression of CCL2 mRNA; [FGF21 gene mutant form results in increased susceptibility to Fructose] which results in increased expression of CCL3 mRNA; [FGF21 gene mutant form results in increased susceptibility to Fructose] which results in increased expression of CD68 mRNA; [FGF21 gene mutant form results in increased susceptibility to Fructose] which results in increased expression of DGAT1 mRNA; [FGF21 gene mutant form results in increased susceptibility to Fructose] which results in increased expression of MMP2 mRNA; [FGF21 gene mutant form results in increased susceptibility to Fructose] which results in increased expression of TGFB1 mRNA; [FGF21 gene mutant form results in increased susceptibility to Fructose] which results in increased expression of TGFB2 mRNA; FGF21 gene mutant form inhibits the reaction [Fructose results in increased expression of ACACA mRNA]; FGF21 gene mutant form inhibits the reaction [Fructose results in increased expression of ACACB mRNA]; FGF21 gene mutant form inhibits the reaction [Fructose results in increased expression of ALDOB mRNA]; FGF21 gene mutant form inhibits the reaction [Fructose results in increased expression of FASN mRNA]; FGF21 gene mutant form inhibits the reaction [Fructose results in increased expression of KHK mRNA]; FGF21 gene mutant form inhibits the reaction [Fructose results in increased expression of MLXIPL mRNA alternative form]; FGF21 gene mutant form inhibits the reaction [Fructose results in increased expression of MTTP mRNA]; FGF21 gene mutant form inhibits the reaction [Fructose results in increased expression of PKLR mRNA]; FGF21 gene mutant form inhibits the reaction [Fructose results in increased expression of SCD1 mRNA]; FGF21 gene mutant form inhibits the reaction [Fructose results in increased secretion of very low density lipoprotein triglyceride]; MLXIPL gene mutant form inhibits the reaction [Fructose results in increased expression of FGF21 mRNA]; MLXIPL gene mutant form inhibits the reaction [Fructose results in increased secretion of FGF21 protein] |
CTD |
PMID:28123933 |
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NCBI chr 1:101,595,579...101,596,822
Ensembl chr 1:101,595,579...101,596,822
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G |
Fhl2 |
four and a half LIM domains 2 |
multiple interactions |
EXP |
[Fructose co-treated with bisphenol A] results in decreased expression of FHL2 protein |
CTD |
PMID:26930160 |
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NCBI chr 9:49,920,611...49,994,906
Ensembl chr 9:49,920,854...49,950,093
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G |
Fos |
Fos proto-oncogene, AP-1 transcription factor subunit |
multiple interactions increases expression |
EXP |
Dactinomycin inhibits the reaction [Fructose results in increased expression of FOS mRNA] |
CTD |
PMID:11123204 PMID:11557636 |
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NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
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G |
Foxo1 |
forkhead box O1 |
multiple interactions increases expression |
EXP |
Fructose results in increased expression of and affects the localization of FOXO1 protein; Fructose results in increased expression of and results in increased phosphorylation of FOXO1 protein; Quercetin inhibits the reaction [Fructose results in increased expression of and affects the localization of FOXO1 protein]; Quercetin inhibits the reaction [Fructose results in increased expression of and results in increased phosphorylation of FOXO1 protein]; Rosiglitazone inhibits the reaction [Fructose results in increased expression of FOXO1 mRNA] |
CTD |
PMID:19196556 PMID:23533474 |
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NCBI chr 2:141,451,234...141,527,016
Ensembl chr 2:141,451,234...141,527,016
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G |
Fth1 |
ferritin heavy chain 1 |
increases expression |
EXP |
Fructose results in increased expression of FTH1 protein |
CTD |
PMID:26930160 |
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NCBI chr 1:226,030,940...226,033,228
Ensembl chr 1:226,030,938...226,033,228
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G |
G6pc1 |
glucose-6-phosphatase catalytic subunit 1 |
multiple interactions increases expression |
EXP |
Rosiglitazone inhibits the reaction [Fructose results in increased expression of G6PC1 mRNA]; Rosiglitazone inhibits the reaction [Fructose results in increased expression of G6PC1 protein] Fructose results in increased expression of G6PC1 mRNA; Fructose results in increased expression of G6PC1 protein |
CTD |
PMID:14988444 PMID:15150374 PMID:16920846 PMID:18346472 PMID:18556366 PMID:19196556 |
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NCBI chr10:89,286,009...89,296,213
Ensembl chr10:89,285,855...89,296,213
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G |
G6pd |
glucose-6-phosphate dehydrogenase |
increases activity multiple interactions decreases expression |
EXP |
Fructose results in increased activity of G6PD protein Glutamine inhibits the reaction [Fructose results in decreased expression of G6PD protein] |
CTD |
PMID:18346472 PMID:31233715 |
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NCBI chr X:156,274,800...156,293,935
Ensembl chr X:156,274,800...156,293,926
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G |
Gcg |
glucagon |
multiple interactions |
EXP |
GCG protein affects the reaction [Fructose affects the degradation of PKLR mRNA] |
CTD |
PMID:2414297 |
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NCBI chr 3:48,442,635...48,451,650
Ensembl chr 3:48,442,635...48,451,650
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G |
Gck |
glucokinase |
increases activity |
EXP |
Fructose results in increased activity of GCK protein |
CTD |
PMID:20470786 |
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NCBI chr14:86,149,146...86,191,589
Ensembl chr14:86,148,928...86,190,659
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G |
Gckr |
glucokinase regulator |
increases expression |
EXP |
Fructose results in increased expression of GCKR mRNA |
CTD |
PMID:18346472 |
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NCBI chr 6:26,355,296...26,385,761
Ensembl chr 6:26,355,296...26,385,761
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G |
Ghrl |
ghrelin and obestatin prepropeptide |
increases expression |
EXP |
Fructose results in increased expression of GHRL protein |
CTD |
PMID:18627777 |
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NCBI chr 4:145,674,157...145,678,066
Ensembl chr 4:145,674,157...145,678,066
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G |
Glp1r |
glucagon-like peptide 1 receptor |
multiple interactions |
EXP |
[Fructose co-treated with Streptozocin] results in decreased expression of GLP1R mRNA; Ghrelin inhibits the reaction [[Fructose co-treated with Streptozocin] results in decreased expression of GLP1R mRNA] |
CTD |
PMID:31468622 |
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NCBI chr20:9,586,075...9,626,228
Ensembl chr20:9,586,075...9,626,228
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G |
Glul |
glutamate-ammonia ligase |
decreases expression multiple interactions |
EXP |
Fructose results in decreased expression of GLUL protein Allopurinol inhibits the reaction [Fructose results in decreased expression of GLUL protein]; Quercetin inhibits the reaction [Fructose results in decreased expression of GLUL protein] |
CTD |
PMID:24491314 |
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NCBI chr13:71,331,052...71,340,207
Ensembl chr13:71,331,052...71,340,229
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G |
Gnat3 |
G protein subunit alpha transducin 3 |
affects response to substance |
ISO |
GNAT3 protein affects the susceptibility to Fructose |
CTD |
PMID:16740645 |
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NCBI chr 4:13,827,764...13,878,126
Ensembl chr 4:13,827,756...13,878,126
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G |
Gnmt |
glycine N-methyltransferase |
multiple interactions |
ISO |
[Dietary Fats co-treated with Fructose] results in increased expression of GNMT mRNA |
CTD |
PMID:29416063 |
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NCBI chr 9:16,565,274...16,568,626
Ensembl chr 9:16,565,225...16,568,627
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G |
Gpam |
glycerol-3-phosphate acyltransferase, mitochondrial |
multiple interactions increases expression |
EXP |
[Folic Acid affects the susceptibility to Fructose] which affects the expression of GPAM mRNA; Atorvastatin inhibits the reaction [Fructose results in increased expression of GPAM mRNA] |
CTD |
PMID:18346472 PMID:19053045 PMID:31612177 |
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NCBI chr 1:275,843,823...275,906,880
Ensembl chr 1:275,846,819...275,906,686
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G |
Gpld1 |
glycosylphosphatidylinositol specific phospholipase D1 |
increases expression |
ISO |
Fructose results in increased expression of GPLD1 protein |
CTD |
PMID:16219662 |
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NCBI chr17:42,085,027...42,131,344
Ensembl chr17:42,085,028...42,127,678
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G |
Gpt |
glutamic--pyruvic transaminase |
increases activity multiple interactions |
ISO EXP |
Fructose results in increased activity of GPT protein 2-(3-(4-ethoxybenzyl)-4-chlorophenyl)-6-hydroxymethyltetrahydro-2H-pyran-3,4,5-triol inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of GPT protein]; [2-(3-(4-ethoxybenzyl)-4-chlorophenyl)-6-hydroxymethyltetrahydro-2H-pyran-3,4,5-triol co-treated with Atorvastatin] inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of GPT protein]; [Fructose co-treated with Dietary Fats] results in increased expression of GPT protein; Atorvastatin inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of GPT protein] [Fructose co-treated with Ethanol] results in increased expression of GPT protein; Plant Preparations inhibits the reaction [Fructose results in increased activity of GPT protein] |
CTD |
PMID:26858005 PMID:27531227 PMID:32259528 |
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NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931
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G |
Gpx1 |
glutathione peroxidase 1 |
decreases expression |
EXP |
Fructose results in decreased expression of GPX1 mRNA |
CTD |
PMID:16815490 PMID:20470786 |
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NCBI chr 8:117,117,430...117,118,528
Ensembl chr 8:117,117,430...117,118,522
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G |
Gpx4 |
glutathione peroxidase 4 |
decreases expression |
EXP |
Fructose results in decreased expression of GPX4 protein |
CTD |
PMID:21781943 |
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NCBI chr 7:12,516,357...12,519,154
Ensembl chr 7:12,516,352...12,519,154
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G |
Gsr |
glutathione-disulfide reductase |
increases activity |
EXP |
Fructose results in increased activity of GSR protein |
CTD |
PMID:17710547 |
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NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361
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G |
Hamp |
hepcidin antimicrobial peptide |
multiple interactions |
EXP |
[Fructose co-treated with Copper deficiency] results in decreased expression of HAMP protein |
CTD |
PMID:25813056 |
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NCBI chr 1:89,368,021...89,369,960
Ensembl chr 1:89,368,021...89,369,960
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G |
Havcr1 |
hepatitis A virus cellular receptor 1 |
multiple interactions |
EXP |
2-(3-(4-ethoxybenzyl)-4-chlorophenyl)-6-hydroxymethyltetrahydro-2H-pyran-3,4,5-triol inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of HAVCR1 protein]; 2-(3-(4-ethoxybenzyl)-4-chlorophenyl)-6-hydroxymethyltetrahydro-2H-pyran-3,4,5-triol promotes the reaction [Metformin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of HAVCR1 protein]]; [Streptozocin co-treated with Fructose] results in increased expression of HAVCR1 protein; Metformin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of HAVCR1 protein]; Metformin promotes the reaction [2-(3-(4-ethoxybenzyl)-4-chlorophenyl)-6-hydroxymethyltetrahydro-2H-pyran-3,4,5-triol inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of HAVCR1 protein]] |
CTD |
PMID:30551545 |
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NCBI chr10:31,813,819...31,860,934
Ensembl chr10:31,813,814...31,848,379
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G |
Hbb |
hemoglobin subunit beta |
multiple interactions |
EXP |
Fructose promotes the reaction [Glucose binds to HBB protein]; geraniol inhibits the reaction [Fructose promotes the reaction [Glucose binds to HBB protein]]; Pioglitazone inhibits the reaction [Fructose promotes the reaction [Glucose binds to HBB protein]] |
CTD |
PMID:25679220 |
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NCBI chr 1:168,971,269...168,972,680
Ensembl chr 1:168,971,274...168,972,725
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G |
Hmgcr |
3-hydroxy-3-methylglutaryl-CoA reductase |
multiple interactions increases expression |
EXP |
[6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in decreased activity of SIRT1 protein] inhibits the reaction [Fructose results in increased expression of HMGCR mRNA]; [Niacinamide results in decreased activity of SIRT1 protein] inhibits the reaction [Fructose results in increased expression of HMGCR mRNA]; Rotenone inhibits the reaction [Fructose results in increased expression of HMGCR mRNA]; Tea inhibits the reaction [Fructose results in increased expression of HMGCR mRNA] |
CTD |
PMID:19193814 PMID:21212096 |
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NCBI chr 2:27,480,224...27,500,654
Ensembl chr 2:27,480,226...27,500,654
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G |
Hmgcs2 |
3-hydroxy-3-methylglutaryl-CoA synthase 2 |
multiple interactions |
EXP |
[Fructose co-treated with Copper deficiency] results in decreased expression of HMGCS2 mRNA; gadolinium chloride promotes the reaction [[Fructose co-treated with Copper deficiency] results in decreased expression of HMGCS2 mRNA] |
CTD |
PMID:25813056 |
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NCBI chr 2:200,452,623...200,480,785
Ensembl chr 2:200,452,624...200,479,423
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G |
Hmox1 |
heme oxygenase 1 |
multiple interactions increases expression |
EXP ISO |
2-(3-(4-ethoxybenzyl)-4-chlorophenyl)-6-hydroxymethyltetrahydro-2H-pyran-3,4,5-triol inhibits the reaction [[Fructose co-treated with Dietary Fats] results in decreased expression of HMOX1 protein]; [Atorvastatin co-treated with 2-(3-(4-ethoxybenzyl)-4-chlorophenyl)-6-hydroxymethyltetrahydro-2H-pyran-3,4,5-triol] inhibits the reaction [[Fructose co-treated with Dietary Fats] results in decreased expression of HMOX1 protein]; [Curcumin co-treated with Fructose] results in increased expression of HMOX1 protein; [Fructose co-treated with Dietary Fats] results in decreased expression of HMOX1 protein; [Hemin co-treated with Fructose] results in increased expression of HMOX1 protein; Atorvastatin inhibits the reaction [[Fructose co-treated with Dietary Fats] results in decreased expression of HMOX1 protein]; caffeic acid phenethyl ester inhibits the reaction [Fructose results in increased expression of HMOX1 protein] Fructose results in increased expression of HMOX1 mRNA |
CTD |
PMID:24508943 PMID:25268984 PMID:28257781 PMID:31655124 PMID:32259528 |
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NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
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G |
Hnf4a |
hepatocyte nuclear factor 4, alpha |
multiple interactions decreases expression |
ISO EXP |
Cerulenin inhibits the reaction [Fructose results in decreased expression of HNF4A mRNA] Fructose results in decreased expression of HNF4A mRNA; Fructose results in decreased expression of HNF4A protein Berberine inhibits the reaction [Fructose results in decreased expression of HNF4A mRNA]; Berberine inhibits the reaction [Fructose results in decreased expression of HNF4A protein]; rosiglitazone inhibits the reaction [Fructose results in decreased expression of HNF4A mRNA] |
CTD |
PMID:17992261 PMID:18563319 PMID:19196556 |
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NCBI chr 3:159,902,441...159,965,003
Ensembl chr 3:159,902,441...159,965,003
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G |
Hnrnpa2b1 |
heterogeneous nuclear ribonucleoprotein A2/B1 |
multiple interactions decreases expression |
EXP |
[Fructose co-treated with bisphenol A] results in increased expression of HNRNPA2B1 protein Fructose results in decreased expression of HNRNPA2B1 protein |
CTD |
PMID:26930160 |
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NCBI chr 4:81,237,496...81,241,281
Ensembl chr 4:81,237,496...81,241,282
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G |
Hnrnpa3 |
heterogeneous nuclear ribonucleoprotein A3 |
multiple interactions |
EXP |
[Fructose co-treated with bisphenol A] results in increased expression of HNRNPA3 protein |
CTD |
PMID:26930160 |
|
NCBI chr 3:62,481,222...62,491,356
Ensembl chr 3:62,481,323...62,487,227
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G |
Hnrnpk |
heterogeneous nuclear ribonucleoprotein K |
multiple interactions |
EXP |
[Fructose co-treated with bisphenol A] results in increased expression of HNRNPK protein |
CTD |
PMID:26930160 |
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NCBI chr17:6,664,730...6,676,753
Ensembl chr17:6,665,659...6,676,654
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G |
Hoxc9 |
homeobox C9 |
multiple interactions decreases expression |
EXP |
[Ozone co-treated with Fructose] results in decreased expression of HOXC9 mRNA; [Particulate Matter co-treated with Ozone co-treated with Fructose] results in decreased expression of HOXC9 mRNA; Fructose affects the reaction [Particulate Matter results in decreased expression of HOXC9 mRNA] Fructose results in decreased expression of HOXC9 mRNA |
CTD |
PMID:23968387 |
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NCBI chr 7:144,592,462...144,598,807
Ensembl chr 7:144,595,960...144,598,632
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G |
Hprt1 |
hypoxanthine phosphoribosyltransferase 1 |
decreases expression |
ISO |
Fructose results in decreased expression of HPRT1 mRNA |
CTD |
PMID:31655124 |
|
NCBI chr X:158,196,640...158,228,815
Ensembl chr X:158,197,149...158,228,749 Ensembl chr X:158,197,149...158,228,749
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G |
Hspa1b |
heat shock protein family A (Hsp70) member 1B |
increases expression |
EXP |
Fructose results in increased expression of HSPA1B mRNA |
CTD |
PMID:15150374 |
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NCBI chr20:4,877,638...4,880,112
Ensembl chr20:2,699,712...2,701,815
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G |
Hspa5 |
heat shock protein family A (Hsp70) member 5 |
increases expression multiple interactions |
ISO |
Fructose results in increased expression of HSPA5 mRNA; Fructose results in increased expression of HSPA5 protein Phenylbutyrates inhibits the reaction [Fructose results in increased expression of HSPA5 protein] |
CTD |
PMID:22698815 |
|
NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
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G |
Hspd1 |
heat shock protein family D (Hsp60) member 1 |
multiple interactions increases expression |
EXP |
Amlodipine inhibits the reaction [Fructose results in increased expression of HSPD1 protein]; rosiglitazone inhibits the reaction [Fructose results in increased expression of HSPD1 protein] |
CTD |
PMID:18948349 PMID:26930160 |
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NCBI chr 9:61,680,529...61,691,202
Ensembl chr 9:61,680,530...61,690,956
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G |
Hspe1 |
heat shock protein family E (Hsp10) member 1 |
multiple interactions |
EXP |
[Fructose co-treated with bisphenol A] results in increased expression of HSPE1 protein |
CTD |
PMID:26930160 |
|
NCBI chr 9:61,691,246...61,724,948
Ensembl chr 9:61,692,154...61,694,599
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G |
Icam1 |
intercellular adhesion molecule 1 |
multiple interactions increases expression |
ISO EXP |
2,2'-(hydroxynitrosohydrazono)bis-ethanamine inhibits the reaction [Fructose results in increased expression of ICAM1 protein]; Adenosine Triphosphate inhibits the reaction [Fructose results in increased expression of ICAM1 protein] Metformin inhibits the reaction [Fructose results in increased expression of ICAM1 protein modified form]; resveratrol inhibits the reaction [Fructose results in increased expression of ICAM1 protein modified form] Fructose results in increased expression of ICAM1 mRNA; Fructose results in increased expression of ICAM1 protein |
CTD |
PMID:18508964 PMID:25108154 |
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NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
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G |
Idh3b |
isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit beta |
decreases expression |
EXP |
Fructose results in decreased expression of IDH3B protein |
CTD |
PMID:26930160 |
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NCBI chr 3:122,808,564...122,813,638
Ensembl chr 3:122,808,564...122,813,583
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G |
Igfbp3 |
insulin-like growth factor binding protein 3 |
multiple interactions |
EXP |
[Fructose co-treated with Ozone co-treated with Particulate Matter] results in decreased expression of IGFBP3 mRNA; [Fructose co-treated with Ozone] results in decreased expression of IGFBP3 mRNA; [Particulate Matter co-treated with Fructose] results in decreased expression of IGFBP3 mRNA; Fructose affects the reaction [Particulate Matter results in decreased expression of IGFBP3 mRNA] |
CTD |
PMID:23968387 |
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NCBI chr14:87,457,647...87,465,374
Ensembl chr14:87,457,647...87,465,374
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G |
Ikbkb |
inhibitor of nuclear factor kappa B kinase subunit beta |
increases phosphorylation multiple interactions |
EXP |
Fructose results in increased phosphorylation of IKBKB protein Allopurinol inhibits the reaction [Fructose results in increased phosphorylation of IKBKB protein]; Quercetin inhibits the reaction [Fructose results in increased phosphorylation of IKBKB protein] |
CTD |
PMID:24491314 |
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NCBI chr16:74,177,233...74,230,809
Ensembl chr16:74,177,215...74,230,815
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G |
Il10 |
interleukin 10 |
multiple interactions decreases expression |
EXP |
[Fructose co-treated with Ozone co-treated with Particulate Matter] results in decreased expression of IL10 mRNA; Fructose affects the reaction [Ozone results in decreased expression of IL10 mRNA]; Fructose affects the reaction [Particulate Matter results in decreased expression of IL10 mRNA] Fructose results in decreased expression of IL10 mRNA |
CTD |
PMID:23968387 |
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NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
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G |
Il18 |
interleukin 18 |
multiple interactions increases expression |
EXP |
Allopurinol inhibits the reaction [Fructose results in increased expression of IL18 protein]; Felodipine inhibits the reaction [Fructose results in increased expression of IL18 mRNA]; Felodipine inhibits the reaction [Fructose results in increased expression of IL18 protein]; Quercetin inhibits the reaction [Fructose results in increased expression of IL18 protein]; Rutin inhibits the reaction [Fructose results in increased expression of IL18 protein] Fructose results in increased expression of IL18 mRNA; Fructose results in increased expression of IL18 protein |
CTD |
PMID:18504504 PMID:22426011 |
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NCBI chr 8:55,009,666...55,016,286
Ensembl chr 8:54,993,859...55,016,299
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G |
Il1b |
interleukin 1 beta |
increases expression increases secretion multiple interactions |
EXP ISO |
Fructose results in increased expression of IL1B protein Fructose results in increased secretion of IL1B protein [Fructose co-treated with Ethanol] results in increased expression of IL1B mRNA [gadolinium chloride co-treated with Fructose co-treated with Copper deficiency] results in decreased expression of IL1B mRNA; Allopurinol inhibits the reaction [Fructose results in increased expression of IL1B protein]; geraniol inhibits the reaction [Fructose results in increased expression of IL1B protein]; geraniol inhibits the reaction [Fructose results in increased secretion of IL1B protein]; Pioglitazone inhibits the reaction [Fructose results in increased secretion of IL1B protein]; PTMA protein inhibits the reaction [Fructose results in increased expression of IL1B protein]; Quercetin inhibits the reaction [Fructose results in increased expression of IL1B protein]; Rutin inhibits the reaction [Fructose results in increased expression of IL1B protein]; tributylhexadecylphosphonium bromide inhibits the reaction [Fructose results in increased expression of IL1B protein] |
CTD |
PMID:15885234 PMID:22426011 PMID:24491314 PMID:25679220 PMID:25813056 PMID:26358169 PMID:26858005 PMID:31005848 |
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NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
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G |
Il2 |
interleukin 2 |
increases expression |
EXP |
Fructose results in increased expression of IL2 protein |
CTD |
PMID:15885234 |
|
NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854
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G |
Il6 |
interleukin 6 |
multiple interactions increases expression |
EXP ISO |
[gadolinium chloride co-treated with Fructose co-treated with Copper deficiency] results in decreased expression of IL6 mRNA; Allopurinol inhibits the reaction [Fructose results in increased expression of IL6 protein]; galangin inhibits the reaction [Fructose results in increased expression of IL6 protein]; Genistein inhibits the reaction [Fructose results in increased expression of IL6 protein]; geraniol inhibits the reaction [Fructose results in increased expression of IL6 protein]; Metformin inhibits the reaction [Fructose results in increased expression of IL6 protein]; PTMA protein inhibits the reaction [Fructose results in increased expression of IL6 protein]; Quercetin inhibits the reaction [Fructose results in increased expression of IL6 protein]; Resveratrol inhibits the reaction [Fructose results in increased expression of IL6 protein]; Rutin inhibits the reaction [Fructose results in increased expression of IL6 protein]; tributylhexadecylphosphonium bromide inhibits the reaction [Fructose results in increased expression of IL6 protein] |
CTD |
PMID:15885234 PMID:21704028 PMID:21708140 PMID:22426011 PMID:25108154 PMID:25813056 PMID:26358169 PMID:27531227 PMID:31005848 PMID:31672515 |
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NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
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G |
Ins2 |
insulin 2 |
decreases response to substance increases secretion increases expression multiple interactions |
ISO EXP |
Fructose results in decreased susceptibility to INS protein Fructose results in increased secretion of INS protein Fructose results in increased expression of INS protein; Fructose results in increased expression of INS2 mRNA Curcumin inhibits the reaction [Fructose results in increased expression of INS protein]; Hemin inhibits the reaction [Fructose results in increased expression of INS protein]; INS protein inhibits the reaction [Fructose results in increased expression of AGTR1A mRNA]; Quercetin inhibits the reaction [Fructose results in increased expression of INS2 mRNA] |
CTD |
PMID:12010179 PMID:18360027 PMID:23533474 PMID:25268984 PMID:26713546 |
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NCBI chr 1:215,856,967...215,858,034
Ensembl chr 1:215,856,971...215,858,034
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G |
Insig1 |
insulin induced gene 1 |
decreases expression increases expression multiple interactions |
ISO |
Fructose results in decreased expression of INSIG1 protein Fructose results in increased expression of INSIG1 mRNA Phenylbutyrates inhibits the reaction [Fructose results in decreased expression of INSIG1 protein] |
CTD |
PMID:22698815 |
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NCBI chr 4:342,302...350,515
Ensembl chr 4:342,302...350,515
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G |
Insig2 |
insulin induced gene 2 |
increases expression |
ISO |
Fructose results in increased expression of INSIG2 mRNA |
CTD |
PMID:22698815 |
|
NCBI chr13:37,264,818...37,292,718
Ensembl chr13:37,266,312...37,287,458
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G |
Insr |
insulin receptor |
decreases expression decreases phosphorylation multiple interactions |
EXP |
Fructose results in decreased expression of INSR mRNA; Fructose results in decreased expression of INSR protein Fructose results in decreased phosphorylation of INSR protein [Fructose co-treated with Oleanolic Acid] results in increased expression of INSR mRNA; [Fructose co-treated with Sodium Chloride, Dietary deficiency] results in decreased expression of INSR mRNA; [Fructose co-treated with Sodium Chloride, Dietary deficiency] results in decreased expression of INSR protein; Allopurinol inhibits the reaction [Fructose results in decreased phosphorylation of INSR protein]; Quercetin inhibits the reaction [Fructose results in decreased phosphorylation of INSR protein]; Rutin inhibits the reaction [Fructose results in decreased phosphorylation of INSR protein] |
CTD |
PMID:14573337 PMID:14633139 PMID:22426011 PMID:24491314 PMID:24704288 |
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NCBI chr12:1,682,527...1,816,414
Ensembl chr12:1,680,957...1,816,414
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G |
Irf3 |
interferon regulatory factor 3 |
multiple interactions |
ISO |
[Fructose co-treated with Ethanol] results in increased expression of IRF3 protein; Fructose promotes the reaction [Ethanol results in increased expression of IRF3 mRNA] |
CTD |
PMID:26858005 |
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NCBI chr 1:100,992,244...100,997,202
Ensembl chr 1:100,992,405...100,997,198
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G |
Irf7 |
interferon regulatory factor 7 |
multiple interactions increases expression |
ISO |
[Fructose co-treated with Ethanol] results in increased expression of IRF7 protein Fructose results in increased expression of IRF7 protein |
CTD |
PMID:26858005 |
|
NCBI chr 1:214,249,388...214,252,909
Ensembl chr 1:214,248,837...214,252,456
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G |
Irs1 |
insulin receptor substrate 1 |
decreases expression increases phosphorylation decreases phosphorylation multiple interactions affects phosphorylation |
EXP ISO |
Fructose results in decreased expression of IRS1 mRNA; Fructose results in decreased expression of IRS1 protein Fructose results in increased phosphorylation of IRS1 protein Fructose results in decreased phosphorylation of IRS1 protein [Fructose co-treated with Oleanolic Acid] results in increased expression of IRS1 mRNA; [Fructose co-treated with Oleanolic Acid] results in increased expression of IRS1 protein; [Fructose co-treated with resveratrol] results in increased expression of IRS1 mRNA; Allopurinol inhibits the reaction [Fructose results in decreased phosphorylation of IRS1 protein]; Curcumin inhibits the reaction [Fructose affects the phosphorylation of IRS1 protein]; NOS3 protein inhibits the reaction [Fructose results in decreased expression of IRS1 protein]; Oleanolic Acid inhibits the reaction [Fructose results in increased phosphorylation of IRS1 protein]; Quercetin inhibits the reaction [Fructose results in decreased phosphorylation of IRS1 protein]; Rutin inhibits the reaction [Fructose results in decreased phosphorylation of IRS1 protein] |
CTD |
PMID:19008412 PMID:19165636 PMID:22426011 PMID:24704288 PMID:26488877 PMID:26713546 PMID:31672515 |
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NCBI chr 9:88,033,668...88,086,488
Ensembl chr 9:88,033,668...88,086,488
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G |
Irs2 |
insulin receptor substrate 2 |
decreases expression multiple interactions |
EXP |
Fructose results in decreased expression of IRS2 mRNA; Fructose results in decreased expression of IRS2 protein NOS3 protein inhibits the reaction [Fructose results in decreased expression of IRS2 protein]; resveratrol inhibits the reaction [Fructose results in decreased expression of IRS2 mRNA] |
CTD |
PMID:19008412 PMID:19165636 PMID:26488877 |
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NCBI chr16:83,824,515...83,848,569
Ensembl chr16:83,824,430...83,848,684
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G |
Itgb1 |
integrin subunit beta 1 |
decreases expression |
ISO |
Fructose results in decreased expression of ITGB1 mRNA |
CTD |
PMID:31655124 |
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NCBI chr19:61,677,512...61,725,537
Ensembl chr19:61,677,542...61,725,535
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G |
Itih3 |
inter-alpha trypsin inhibitor, heavy chain 3 |
decreases expression |
EXP |
Fructose results in decreased expression of ITIH3 protein |
CTD |
PMID:26930160 |
|
NCBI chr16:6,983,779...7,007,288
Ensembl chr16:6,992,062...7,007,287
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G |
Jak2 |
Janus kinase 2 |
decreases phosphorylation multiple interactions |
EXP |
Fructose results in decreased phosphorylation of JAK2 protein Quercetin inhibits the reaction [Fructose results in decreased phosphorylation of JAK2 protein]; Rutin inhibits the reaction [Fructose results in decreased phosphorylation of JAK2 protein] |
CTD |
PMID:22426011 |
|
NCBI chr 1:247,398,667...247,457,521
Ensembl chr 1:247,398,598...247,458,509
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G |
Jun |
Jun proto-oncogene, AP-1 transcription factor subunit |
multiple interactions increases expression |
EXP |
Dactinomycin inhibits the reaction [Fructose results in increased expression of JUN mRNA] |
CTD |
PMID:11123204 PMID:11557636 |
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NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
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G |
Jup |
junction plakoglobin |
multiple interactions |
EXP |
[Fructose co-treated with bisphenol A] results in increased expression of JUP protein |
CTD |
PMID:26930160 |
|
NCBI chr10:88,280,517...88,307,451
Ensembl chr10:88,279,632...88,307,412
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G |
Kdr |
kinase insert domain receptor |
multiple interactions |
EXP |
[bisphenol A co-treated with Fructose] results in increased expression of KDR mRNA |
CTD |
PMID:27622962 |
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NCBI chr14:34,727,677...34,787,127
Ensembl chr14:34,727,623...34,787,183
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G |
Khk |
ketohexokinase |
multiple interactions increases expression |
ISO EXP |
KHK protein promotes the reaction [Fructose results in decreased abundance of Adenosine Triphosphate]; KHK protein promotes the reaction [Fructose results in increased abundance of Reactive Oxygen Species]; KHK protein promotes the reaction [Fructose results in increased secretion of CCL2 protein] Atorvastatin inhibits the reaction [Fructose results in increased expression of KHK protein] Fructose results in increased expression of KHK mRNA; Fructose results in increased expression of KHK protein FGF21 gene mutant form inhibits the reaction [Fructose results in increased expression of KHK mRNA]; Fructose results in increased expression of and results in increased activity of KHK protein |
CTD |
PMID:15066988 PMID:18346472 PMID:18395287 PMID:19158351 PMID:21122807 PMID:26858005 PMID:28123933 |
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NCBI chr 6:26,810,577...26,821,013
Ensembl chr 6:26,810,579...26,820,959
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G |
Klk1 |
kallikrein 1 |
multiple interactions |
EXP |
KLK1 protein inhibits the reaction [Fructose results in increased expression of AGTR1B mRNA]; KLK1 protein inhibits the reaction [Fructose results in increased expression of EDN1 mRNA]; KLK1 protein inhibits the reaction [Fructose results in increased expression of EDNRA mRNA] |
CTD |
PMID:14568997 |
|
NCBI chr 1:100,131,562...100,135,556
Ensembl chr 1:100,059,967...100,203,329 Ensembl chr 1:100,059,967...100,203,329 Ensembl chr 1:100,059,967...100,203,329
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G |
Kng2 |
kininogen 2 |
decreases expression |
EXP |
Fructose results in decreased expression of MAP1 protein |
CTD |
PMID:26930160 |
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NCBI chr11:81,509,185...81,516,759
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G |
Krt18 |
keratin 18 |
increases expression |
EXP |
Fructose increases expression of Krt18 protein in liver and serum |
RGD |
PMID:29989845 |
RGD:26884460 |
NCBI chr 7:143,629,455...143,633,131
Ensembl chr 7:143,629,455...143,633,131
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G |
Lcn2 |
lipocalin 2 |
multiple interactions |
EXP |
2-(3-(4-ethoxybenzyl)-4-chlorophenyl)-6-hydroxymethyltetrahydro-2H-pyran-3,4,5-triol inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of LCN2 protein]; 2-(3-(4-ethoxybenzyl)-4-chlorophenyl)-6-hydroxymethyltetrahydro-2H-pyran-3,4,5-triol inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of LCN2 protein]; [2-(3-(4-ethoxybenzyl)-4-chlorophenyl)-6-hydroxymethyltetrahydro-2H-pyran-3,4,5-triol co-treated with Atorvastatin] inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of LCN2 protein]; [Fructose co-treated with Dietary Fats] results in increased expression of LCN2 protein; [Streptozocin co-treated with Fructose] results in increased expression of LCN2 protein; Atorvastatin inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of LCN2 protein]; Metformin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of LCN2 protein] |
CTD |
PMID:30551545 PMID:32259528 |
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NCBI chr 3:11,414,189...11,417,534
Ensembl chr 3:11,414,186...11,417,546
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G |
Lct |
lactase |
increases expression |
EXP |
Fructose results in increased expression of LCT mRNA |
CTD |
PMID:11242478 |
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NCBI chr13:44,998,414...45,040,593
Ensembl chr13:44,998,414...45,040,593
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G |
Ldhb |
lactate dehydrogenase B |
multiple interactions |
EXP |
[Fructose co-treated with bisphenol A] results in decreased expression of LDHB protein |
CTD |
PMID:26930160 |
|
NCBI chr 4:176,701,980...176,719,999
Ensembl chr 4:176,701,983...176,720,012
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G |
Lep |
leptin |
increases secretion increases expression multiple interactions |
EXP |
Fructose results in increased secretion of LEP protein Fructose results in increased expression of LEP mRNA; Fructose results in increased expression of LEP protein [Fenofibrate co-treated with Resveratrol] inhibits the reaction [Fructose results in increased expression of LEP mRNA]; [Ozone co-treated with Fructose] results in increased expression of LEP mRNA; [Particulate Matter co-treated with Fructose] results in increased expression of LEP mRNA; [Particulate Matter co-treated with Ozone co-treated with Fructose] results in increased expression of LEP mRNA; Allopurinol inhibits the reaction [Fructose results in increased expression of LEP protein]; Atorvastatin affects the reaction [Fructose results in increased expression of LEP protein]; Fenofibrate inhibits the reaction [Fructose results in increased expression of LEP mRNA]; Quercetin inhibits the reaction [Fructose results in increased expression of LEP protein]; Quercetin inhibits the reaction [Fructose results in increased secretion of LEP protein]; Resveratrol inhibits the reaction [Fructose results in increased expression of LEP mRNA]; Rutin inhibits the reaction [Fructose results in increased expression of LEP protein] |
CTD |
PMID:10780946 PMID:11741341 PMID:18627777 PMID:19165636 PMID:21122807 PMID:22426011 PMID:23016136 PMID:23533474 PMID:23968387 PMID:26973390 |
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NCBI chr 4:56,337,695...56,351,818
Ensembl chr 4:56,337,695...56,351,818
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G |
Lepr |
leptin receptor |
multiple interactions |
EXP |
Allopurinol inhibits the reaction [Fructose results in increased expression of and results in increased phosphorylation of LEPR protein]; Fructose results in increased expression of and results in increased phosphorylation of LEPR protein; Quercetin inhibits the reaction [Fructose results in increased expression of and results in increased phosphorylation of LEPR protein]; Rutin inhibits the reaction [Fructose results in increased expression of and results in increased phosphorylation of LEPR protein] |
CTD |
PMID:22426011 |
|
NCBI chr 5:120,503,475...120,682,281
Ensembl chr 5:120,564,645...120,682,221
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G |
Lgals9 |
galectin 9 |
multiple interactions decreases expression |
EXP |
Allopurinol inhibits the reaction [Fructose results in decreased expression of LGALS9 mRNA]; Allopurinol inhibits the reaction [Fructose results in decreased expression of LGALS9 protein]; Quercetin inhibits the reaction [Fructose results in decreased expression of LGALS9 mRNA]; Quercetin inhibits the reaction [Fructose results in decreased expression of LGALS9 protein]; Rutin inhibits the reaction [Fructose results in decreased expression of LGALS9 mRNA]; Rutin inhibits the reaction [Fructose results in decreased expression of LGALS9 protein] Fructose results in decreased expression of LGALS9 mRNA; Fructose results in decreased expression of LGALS9 protein |
CTD |
PMID:19605544 |
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NCBI chr10:64,737,022...64,760,195
Ensembl chr10:64,737,022...64,760,201
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G |
Maoa |
monoamine oxidase A |
multiple interactions |
EXP |
[Fructose co-treated with bisphenol A] results in increased expression of MAOA protein |
CTD |
PMID:26930160 |
|
NCBI chr X:6,554,698...6,620,722
Ensembl chr X:6,554,698...6,620,722
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G |
Mapk1 |
mitogen activated protein kinase 1 |
increases phosphorylation decreases phosphorylation multiple interactions |
EXP |
Fructose results in increased phosphorylation of MAPK1 protein Fructose results in decreased phosphorylation of MAPK1 protein Curcumin inhibits the reaction [Fructose results in increased phosphorylation of MAPK1 protein]; Quercetin inhibits the reaction [Fructose results in decreased phosphorylation of MAPK1 protein]; Rutin inhibits the reaction [Fructose results in decreased phosphorylation of MAPK1 protein] |
CTD |
PMID:22426011 PMID:26713546 |
|
NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
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G |
Mapk3 |
mitogen activated protein kinase 3 |
increases phosphorylation decreases phosphorylation multiple interactions |
EXP |
Fructose results in increased phosphorylation of MAPK3 protein Fructose results in decreased phosphorylation of MAPK3 protein Curcumin inhibits the reaction [Fructose results in increased phosphorylation of MAPK3 protein]; Quercetin inhibits the reaction [Fructose results in decreased phosphorylation of MAPK3 protein]; Rutin inhibits the reaction [Fructose results in decreased phosphorylation of MAPK3 protein] |
CTD |
PMID:22426011 PMID:26713546 |
|
NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
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G |
Mapk8 |
mitogen-activated protein kinase 8 |
multiple interactions increases expression |
EXP |
imoxin inhibits the reaction [Fructose results in increased expression of MAPK8 protein] |
CTD |
PMID:29430716 |
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NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
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G |
Mir33 |
microRNA 33 |
multiple interactions |
EXP |
[Fructose co-treated with Streptozocin] results in increased expression of MIR33A mRNA; Ghrelin inhibits the reaction [[Fructose co-treated with Streptozocin] results in increased expression of MIR33A mRNA] |
CTD |
PMID:31468622 |
|
NCBI chr 7:123,431,612...123,431,680
Ensembl chr 7:123,431,612...123,431,680
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G |
Mlx |
MAX dimerization protein MLX |
increases expression |
EXP |
Fructose results in increased expression of MLX mRNA |
CTD |
PMID:18346472 |
|
NCBI chr10:88,997,011...89,002,154
Ensembl chr10:88,997,399...89,002,152
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G |
Mlxipl |
MLX interacting protein-like |
multiple interactions decreases expression increases expression increases activity |
EXP ISO |
Atorvastatin inhibits the reaction [Fructose affects the localization of and results in increased activity of MLXIPL protein]; Atorvastatin inhibits the reaction [Fructose results in increased expression of MLXIPL protein]; Fructose affects the localization of and results in increased activity of MLXIPL protein; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Atorvastatin inhibits the reaction [Fructose results in increased activity of MLXIPL protein]] Fructose results in decreased expression of MLXIPL mRNA Fructose results in increased expression of MLXIPL mRNA alternative form FGF21 gene mutant form inhibits the reaction [Fructose results in increased expression of MLXIPL mRNA alternative form]; MLXIPL gene mutant form inhibits the reaction [Fructose results in increased expression of FGF21 mRNA]; MLXIPL gene mutant form inhibits the reaction [Fructose results in increased secretion of FGF21 protein] Fructose results in increased expression of MLXIPL mRNA; Fructose results in increased expression of MLXIPL protein |
CTD |
PMID:18346472 PMID:19053045 PMID:19799862 PMID:21122807 PMID:28123933 |
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NCBI chr12:24,590,645...24,619,639
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G |
Mlycd |
malonyl-CoA decarboxylase |
multiple interactions decreases expression |
EXP |
[Fenofibrate co-treated with resveratrol] inhibits the reaction [Fructose results in decreased expression of MLYCD mRNA]; Fenofibrate inhibits the reaction [Fructose results in decreased expression of MLYCD mRNA]; resveratrol inhibits the reaction [Fructose results in decreased expression of MLYCD mRNA] |
CTD |
PMID:26973390 |
|
NCBI chr19:52,032,950...52,048,773
Ensembl chr19:52,032,886...52,048,753
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G |
Mmp2 |
matrix metallopeptidase 2 |
multiple interactions |
ISO |
[FGF21 gene mutant form results in increased susceptibility to Fructose] which results in increased expression of MMP2 mRNA |
CTD |
PMID:28123933 |
|
NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
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G |
Mmp9 |
matrix metallopeptidase 9 |
increases expression |
ISO |
Fructose results in increased expression of MMP9 mRNA |
CTD |
PMID:31655124 |
|
NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
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G |
Mpst |
mercaptopyruvate sulfurtransferase |
multiple interactions |
EXP |
[Fructose co-treated with bisphenol A] results in decreased expression of MPST protein |
CTD |
PMID:26930160 |
|
NCBI chr 7:119,626,636...119,631,317
Ensembl chr 7:119,626,637...119,631,425
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G |
Msn |
moesin |
multiple interactions |
EXP |
[Fructose co-treated with bisphenol A] results in increased expression of MSN protein |
CTD |
PMID:26930160 |
|
NCBI chr X:65,226,834...65,294,192
Ensembl chr X:65,226,748...65,295,810
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G |
Mt-atp6 |
mitochondrially encoded ATP synthase membrane subunit 6 |
increases expression |
EXP |
Fructose results in increased expression of ATP6 protein |
CTD |
PMID:11934685 |
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NCBI chr MT:7,919...8,599
Ensembl chr MT:7,919...8,599
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G |
Mt-co2 |
mitochondrially encoded cytochrome c oxidase II |
multiple interactions |
EXP |
[Fructose co-treated with bisphenol A] results in decreased expression of COX2 protein |
CTD |
PMID:26930160 |
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NCBI chr MT:7,006...7,689
Ensembl chr MT:7,006...7,689
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G |
Mt1-ps2 |
metallothionein 1, pseudogene 2 |
multiple interactions increases expression |
EXP |
Atorvastatin inhibits the reaction [Fructose results in increased expression of MT1-PS2 mRNA] |
CTD |
PMID:21122807 |
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G |
Mt2A |
metallothionein 2A |
increases expression multiple interactions |
EXP |
Fructose results in increased expression of MT2A mRNA Atorvastatin inhibits the reaction [Fructose results in increased expression of MT2A mRNA] |
CTD |
PMID:21122807 |
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NCBI chr19:11,307,966...11,308,740
Ensembl chr19:11,307,967...11,308,740
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G |
Mttp |
microsomal triglyceride transfer protein |
multiple interactions increases expression |
EXP ISO |
[Fructose co-treated with Copper deficiency] results in decreased expression of MTTP mRNA FGF21 gene mutant form inhibits the reaction [Fructose results in increased expression of MTTP mRNA] |
CTD |
PMID:25813056 PMID:28123933 |
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NCBI chr 2:243,366,181...243,407,608
Ensembl chr 2:243,366,181...243,407,608
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G |
Myc |
MYC proto-oncogene, bHLH transcription factor |
decreases expression |
ISO |
Fructose results in decreased expression of MYC mRNA |
CTD |
PMID:2558650 |
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NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
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G |
Myd88 |
MYD88, innate immune signal transduction adaptor |
multiple interactions |
ISO |
Fructose promotes the reaction [Ethanol results in increased expression of MYD88 mRNA] |
CTD |
PMID:26858005 |
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NCBI chr 8:128,022,512...128,027,462
Ensembl chr 8:128,022,473...128,026,841
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G |
Myh6 |
myosin heavy chain 6 |
increases expression multiple interactions |
ISO |
Fructose results in increased expression of MYH6 mRNA SIRT1 protein affects the reaction [Fructose results in increased expression of MYH6 mRNA] |
CTD |
PMID:18192211 |
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NCBI chr15:33,605,653...33,629,730
Ensembl chr15:33,605,654...33,629,699
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G |
Myh9 |
myosin, heavy chain 9 |
decreases expression multiple interactions |
EXP |
Fructose results in decreased expression of MYH9 protein [Fructose co-treated with bisphenol A] results in increased expression of MYH9 protein |
CTD |
PMID:26930160 |
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NCBI chr 7:118,740,005...118,792,507
Ensembl chr 7:118,741,110...118,792,625
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G |
Ndufa5 |
NADH:ubiquinone oxidoreductase subunit A5 |
multiple interactions |
EXP |
[Fructose co-treated with bisphenol A] results in increased expression of NDUFA5 protein |
CTD |
PMID:26930160 |
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NCBI chr 4:51,590,413...51,598,771
Ensembl chr 4:51,590,413...51,598,771
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G |
Ndufa9 |
NADH:ubiquinone oxidoreductase subunit A9 |
multiple interactions |
EXP |
[Fructose co-treated with bisphenol A] results in decreased expression of NDUFA9 protein |
CTD |
PMID:26930160 |
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NCBI chr 4:159,371,263...159,399,636
Ensembl chr 4:159,371,259...159,399,634
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G |
Nfatc4 |
nuclear factor of activated T-cells 4 |
increases expression multiple interactions |
EXP |
Fructose results in increased expression of NFATC4 protein tributylhexadecylphosphonium bromide inhibits the reaction [Fructose results in increased expression of NFATC4 protein] |
CTD |
PMID:26358169 |
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NCBI chr15:34,493,163...34,502,238
Ensembl chr15:34,493,138...34,504,326
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G |
Nfe2l2 |
nuclear factor, erythroid 2-like 2 |
increases expression multiple interactions |
ISO EXP |
Fructose results in increased expression of NFE2L2 protein 2-(3-(4-ethoxybenzyl)-4-chlorophenyl)-6-hydroxymethyltetrahydro-2H-pyran-3,4,5-triol inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of NFE2L2 protein]; [Atorvastatin co-treated with 2-(3-(4-ethoxybenzyl)-4-chlorophenyl)-6-hydroxymethyltetrahydro-2H-pyran-3,4,5-triol] inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of NFE2L2 protein]; [Fructose co-treated with Dietary Fats] results in increased expression of NFE2L2 protein; Atorvastatin inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of NFE2L2 protein] Fructose promotes the reaction [PPARD gene mutant form results in increased phosphorylation of NFE2L2 protein]; Plant Preparations inhibits the reaction [Fructose results in increased expression of NFE2L2 protein] |
CTD |
PMID:27531227 PMID:29289645 PMID:32259528 |
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NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
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G |
Nfkbia |
NFKB inhibitor alpha |
increases degradation increases phosphorylation multiple interactions |
EXP |
Fructose results in increased degradation of NFKBIA protein Fructose results in increased phosphorylation of NFKBIA protein Allopurinol inhibits the reaction [Fructose results in increased phosphorylation of NFKBIA protein]; Curcumin inhibits the reaction [Fructose results in increased degradation of NFKBIA protein]; Quercetin inhibits the reaction [Fructose results in increased phosphorylation of NFKBIA protein] |
CTD |
PMID:24491314 PMID:26713546 |
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NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
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G |
Ngf |
nerve growth factor |
decreases expression |
EXP |
Fructose results in decreased expression of NGF mRNA; Fructose results in decreased expression of NGF protein |
CTD |
PMID:18585860 |
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NCBI chr 2:204,886,158...204,939,523
Ensembl chr 2:204,886,202...204,940,453
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G |
Ngfr |
nerve growth factor receptor |
decreases expression |
EXP |
Fructose results in decreased expression of NGFR mRNA |
CTD |
PMID:18585860 |
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NCBI chr10:83,389,828...83,408,061
Ensembl chr10:83,389,847...83,408,061
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G |
Nlrp3 |
NLR family, pyrin domain containing 3 |
increases expression multiple interactions |
EXP |
Fructose results in increased expression of NLRP3 protein Allopurinol inhibits the reaction [Fructose results in increased expression of NLRP3 protein]; Quercetin inhibits the reaction [Fructose results in increased expression of NLRP3 protein]; Rutin inhibits the reaction [Fructose results in increased expression of NLRP3 protein] |
CTD |
PMID:22426011 PMID:24491314 |
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NCBI chr10:45,884,324...45,918,290
Ensembl chr10:45,893,018...45,918,254
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G |
Nos2 |
nitric oxide synthase 2 |
multiple interactions increases expression |
EXP ISO |
2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [caryophyllene inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of NOS2 protein]]; [Dietary Fats co-treated with Fructose] results in increased expression of NOS2 protein; [Fructose results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide; caryophyllene inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of NOS2 protein]; iodopravadoline inhibits the reaction [caryophyllene inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of NOS2 protein]]; Pioglitazone inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of NOS2 protein]; Resveratrol inhibits the reaction [Fructose results in increased expression of NOS2 mRNA]; Resveratrol inhibits the reaction [Fructose results in increased expression of NOS2 protein] Fructose results in increased expression of NOS2 mRNA; Fructose results in increased expression of NOS2 protein |
CTD |
PMID:10090849 PMID:26488877 PMID:28257781 PMID:30343038 |
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NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
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G |
Nos3 |
nitric oxide synthase 3 |
multiple interactions decreases expression decreases phosphorylation decreases activity |
EXP ISO |
2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [caryophyllene inhibits the reaction [[Dietary Fats co-treated with Fructose] results in decreased expression of NOS3 protein]]; [bisphenol A co-treated with Fructose] results in increased expression of NOS3 mRNA; [Dietary Fats co-treated with Fructose] results in decreased expression of NOS3 protein; [Resveratrol co-treated with Fructose] results in increased expression of NOS3 mRNA; caryophyllene inhibits the reaction [[Dietary Fats co-treated with Fructose] results in decreased expression of NOS3 protein]; Fish Oils inhibits the reaction [Fructose results in decreased expression of NOS3 mRNA]; Fish Oils inhibits the reaction [Fructose results in decreased expression of NOS3 protein]; iodopravadoline inhibits the reaction [caryophyllene inhibits the reaction [[Dietary Fats co-treated with Fructose] results in decreased expression of NOS3 protein]]; Metformin inhibits the reaction [Fructose results in decreased phosphorylation of NOS3 protein]; NOS3 protein inhibits the reaction [Fructose results in decreased expression of IRS1 protein]; NOS3 protein inhibits the reaction [Fructose results in decreased expression of IRS2 protein]; NOS3 protein inhibits the reaction [Fructose results in decreased phosphorylation of AKT1 protein]; Pioglitazone inhibits the reaction [[Dietary Fats co-treated with Fructose] results in decreased expression of NOS3 protein]; Resveratrol inhibits the reaction [Fructose results in decreased expression of NOS3 mRNA]; Resveratrol inhibits the reaction [Fructose results in decreased expression of NOS3 protein]; Resveratrol inhibits the reaction [Fructose results in decreased phosphorylation of NOS3 protein] Fructose results in decreased expression of NOS3 mRNA; Fructose results in decreased expression of NOS3 protein Fructose results in decreased activity of NOS3 protein |
CTD |
PMID:10580434 PMID:15752949 PMID:18508964 PMID:19008412 PMID:25108154 PMID:26488877 PMID:27622962 PMID:30343038 |
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NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410
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G |
Nox4 |
NADPH oxidase 4 |
increases expression |
EXP |
Fructose results in increased expression of NOX4 mRNA |
CTD |
PMID:17587757 |
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NCBI chr 1:150,796,359...150,976,186
Ensembl chr 1:150,797,084...150,976,194
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G |
Nphs1 |
NPHS1 adhesion molecule, nephrin |
multiple interactions |
EXP |
2-(3-(4-ethoxybenzyl)-4-chlorophenyl)-6-hydroxymethyltetrahydro-2H-pyran-3,4,5-triol inhibits the reaction [[Streptozocin co-treated with Fructose] results in decreased expression of NPHS1 mRNA]; [Streptozocin co-treated with Fructose] results in decreased expression of NPHS1 mRNA; Metformin inhibits the reaction [[Streptozocin co-treated with Fructose] results in decreased expression of NPHS1 mRNA] |
CTD |
PMID:30551545 |
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NCBI chr 1:88,922,346...88,950,560
Ensembl chr 1:88,922,433...88,950,559
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G |
Npy |
neuropeptide Y |
decreases expression |
EXP |
Fructose results in decreased expression of NPY mRNA |
CTD |
PMID:18627777 |
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NCBI chr 4:79,557,856...79,565,059
Ensembl chr 4:79,557,854...79,565,097 Ensembl chr 4:79,557,854...79,565,097
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G |
Nr0b2 |
nuclear receptor subfamily 0, group B, member 2 |
multiple interactions |
ISO |
NR0B2 protein inhibits the reaction [AHR protein results in increased susceptibility to [Dietary Fats co-treated with Fructose]]; NR0B2 protein results in decreased susceptibility to [Dietary Fats co-treated with Fructose] |
CTD |
PMID:29416063 |
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NCBI chr 5:151,776,004...151,779,319
Ensembl chr 5:151,776,004...151,779,319
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G |
Nr2f1 |
nuclear receptor subfamily 2, group F, member 1 |
multiple interactions |
ISO |
Fructose affects the reaction [NR2F1 protein binds to SHBG promoter] |
CTD |
PMID:17992261 |
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NCBI chr 2:5,569,954...5,579,894
Ensembl chr 2:5,569,935...5,579,894
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G |
Oat |
ornithine aminotransferase |
multiple interactions |
EXP |
Fructose inhibits the reaction [Cyclic AMP results in increased activity of OAT protein]; Fructose inhibits the reaction [Cyclic AMP results in increased expression of OAT mRNA] |
CTD |
PMID:2827574 |
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NCBI chr 1:204,562,289...204,582,070
Ensembl chr 1:204,562,289...204,582,070
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G |
Oga |
O-GlcNAcase |
multiple interactions |
EXP |
2-(3-(4-ethoxybenzyl)-4-chlorophenyl)-6-hydroxymethyltetrahydro-2H-pyran-3,4,5-triol inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of and results in increased secretion of OGA protein]; [Streptozocin co-treated with Fructose] results in increased expression of and results in increased secretion of OGA protein; Metformin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of and results in increased secretion of OGA protein] |
CTD |
PMID:30551545 |
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NCBI chr 1:265,506,752...265,542,452
Ensembl chr 1:265,507,451...265,542,276
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G |
Paip2 |
poly(A) binding protein interacting protein 2 |
multiple interactions |
ISO |
Fructose promotes the reaction [PAIP2 protein binds to SLC2A5 3' UTR] |
CTD |
PMID:12820898 |
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NCBI chr18:28,397,320...28,415,911
Ensembl chr18:28,409,955...28,415,910
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G |
Parp1 |
poly (ADP-ribose) polymerase 1 |
increases expression |
ISO |
Fructose results in increased expression of PARP1 protein |
CTD |
PMID:28257781 |
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NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
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G |
Pck1 |
phosphoenolpyruvate carboxykinase 1 |
multiple interactions increases expression increases activity |
EXP |
Rosiglitazone inhibits the reaction [Fructose results in increased expression of PCK1 mRNA]; Rosiglitazone inhibits the reaction [Fructose results in increased expression of PCK1 protein] Fructose results in increased expression of PCK1 mRNA; Fructose results in increased expression of PCK1 protein Fructose results in increased activity of PCK1 protein |
CTD |
PMID:19196556 PMID:21212096 |
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NCBI chr 3:171,213,936...171,219,885
Ensembl chr 3:171,213,936...171,219,871
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G |
Pcmt1 |
protein-L-isoaspartate (D-aspartate) O-methyltransferase 1 |
multiple interactions |
EXP |
[Fructose co-treated with bisphenol A] results in increased expression of PCMT1 protein |
CTD |
PMID:26930160 |
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NCBI chr 1:1,734,863...1,767,759
Ensembl chr 1:1,736,276...1,767,618
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G |
Pdk1 |
pyruvate dehydrogenase kinase 1 |
multiple interactions |
EXP |
[Fructose co-treated with bisphenol A] results in increased expression of PDK1 protein |
CTD |
PMID:26930160 |
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NCBI chr 3:58,530,870...58,561,494
Ensembl chr 3:58,530,870...58,558,027
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G |
Pdx1 |
pancreatic and duodenal homeobox 1 |
multiple interactions increases expression |
EXP |
Quercetin inhibits the reaction [Fructose results in increased expression of PDX1 protein] Fructose results in increased expression of PDX1 mRNA; Fructose results in increased expression of PDX1 protein |
CTD |
PMID:23533474 |
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NCBI chr12:9,496,044...9,501,211
Ensembl chr12:9,496,044...9,501,213
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G |
Pemt |
phosphatidylethanolamine N-methyltransferase |
multiple interactions |
ISO |
[Dietary Fats co-treated with Fructose] results in increased expression of PEMT mRNA; PEMT protein promotes the reaction [AHR protein results in increased susceptibility to [Dietary Fats co-treated with Fructose]] |
CTD |
PMID:29416063 |
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NCBI chr10:46,339,821...46,404,640
Ensembl chr10:46,339,821...46,404,642
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G |
Pf4 |
platelet factor 4 |
increases expression |
ISO |
Fructose results in increased expression of PF4 mRNA |
CTD |
PMID:31655124 |
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NCBI chr14:18,848,549...18,849,258
Ensembl chr14:18,848,549...18,849,258
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G |
Pfkl |
phosphofructokinase, liver type |
increases expression |
EXP |
Fructose results in increased expression of PFKL mRNA |
CTD |
PMID:18346472 |
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NCBI chr20:11,393,860...11,415,889
Ensembl chr20:11,393,877...11,415,882
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G |
Phb2 |
prohibitin 2 |
multiple interactions |
EXP |
[Fructose co-treated with bisphenol A] results in decreased expression of PHB2 protein |
CTD |
PMID:26930160 |
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NCBI chr 4:157,230,769...157,235,375
Ensembl chr 4:157,230,769...157,235,367
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G |
Pik3c2g |
phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma |
multiple interactions |
EXP |
[Fructose co-treated with Oleanolic Acid] results in increased expression of PIK3C2G mRNA |
CTD |
PMID:24704288 |
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NCBI chr 4:173,732,196...174,102,502
Ensembl chr 4:173,732,248...174,102,496
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G |
Pik3r1 |
phosphoinositide-3-kinase regulatory subunit 1 |
multiple interactions |
EXP |
[Fructose co-treated with Dietary Fats] results in decreased expression of PIK3R1 protein |
CTD |
PMID:32259528 |
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NCBI chr 2:31,742,326...31,826,882
Ensembl chr 2:31,745,088...31,826,867
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G |
Pklr |
pyruvate kinase L/R |
increases expression multiple interactions affects expression affects degradation |
ISO EXP |
Fructose results in increased expression of PKLR mRNA Atorvastatin inhibits the reaction [Fructose results in increased expression of PKLR mRNA]; GCG protein affects the reaction [Fructose affects the degradation of PKLR mRNA] Fructose affects the expression of PKLR mRNA FGF21 gene mutant form inhibits the reaction [Fructose results in increased expression of PKLR mRNA]; lactisole inhibits the reaction [Fructose results in increased expression of PKLR mRNA] |
CTD |
PMID:2193023 PMID:2414297 PMID:2824512 PMID:6526814 PMID:6759123 PMID:17786952 PMID:18346472 PMID:19053045 PMID:21122807 PMID:28123933 |
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NCBI chr 2:188,449,158...188,458,034
Ensembl chr 2:188,449,210...188,459,592
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G |
Pkm |
pyruvate kinase M1/2 |
multiple interactions |
EXP |
[Fructose co-treated with bisphenol A] results in decreased expression of PKM protein |
CTD |
PMID:26930160 |
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NCBI chr 8:64,480,963...64,502,957
Ensembl chr 8:64,481,172...64,502,722
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G |
Plat |
plasminogen activator, tissue type |
increases expression |
ISO |
Fructose results in increased expression of PLAT mRNA |
CTD |
PMID:31655124 |
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NCBI chr16:74,098,263...74,122,897
Ensembl chr16:74,098,260...74,122,889
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G |
Pnpla2 |
patatin-like phospholipase domain containing 2 |
increases expression |
ISO |
Fructose results in increased expression of PNPLA2 protein |
CTD |
PMID:28257781 |
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NCBI chr 1:214,434,638...214,439,720
Ensembl chr 1:214,434,626...214,439,720 Ensembl chr 1:214,434,626...214,439,720
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G |
Pomc |
proopiomelanocortin |
decreases expression |
EXP |
Fructose results in decreased expression of POMC mRNA |
CTD |
PMID:18627777 |
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NCBI chr 6:28,382,937...28,388,771
Ensembl chr 6:28,382,962...28,388,967
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G |
Ppara |
peroxisome proliferator activated receptor alpha |
increases expression multiple interactions decreases expression |
EXP ISO |
Fructose results in increased expression of PPARA protein [Plant Preparations co-treated with Fructose] results in increased expression of PPARA protein Fructose results in decreased expression of PPARA protein [2-(3-(4-ethoxybenzyl)-4-chlorophenyl)-6-hydroxymethyltetrahydro-2H-pyran-3,4,5-triol co-treated with Atorvastatin] inhibits the reaction [[Fructose co-treated with Dietary Fats] results in decreased expression of PPARA protein]; [Fructose co-treated with Dietary Fats] results in decreased expression of PPARA protein; Allopurinol inhibits the reaction [Fructose results in decreased expression of PPARA protein]; Atorvastatin inhibits the reaction [Fructose results in increased expression of PPARA protein]; Fenofibrate inhibits the reaction [Fructose results in decreased expression of and results in decreased activity of PPARA protein]; Fructose results in decreased expression of and results in decreased activity of PPARA protein; Quercetin inhibits the reaction [Fructose results in decreased expression of PPARA protein]; Rutin inhibits the reaction [Fructose results in decreased expression of PPARA protein] |
CTD |
PMID:11934685 PMID:12065722 PMID:22426011 PMID:27531227 PMID:28257781 PMID:32259528 |
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NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752
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G |
Ppard |
peroxisome proliferator-activated receptor delta |
multiple interactions decreases response to substance |
ISO |
[PPARD mRNA results in decreased susceptibility to Fructose] which results in decreased expression of VLDLR mRNA; Fructose inhibits the reaction [PPARD mRNA results in decreased expression of VLDLR mRNA]; Fructose promotes the reaction [PPARD gene mutant form results in increased expression of VLDLR mRNA]; Fructose promotes the reaction [PPARD gene mutant form results in increased expression of VLDLR protein]; Fructose promotes the reaction [PPARD gene mutant form results in increased phosphorylation of NFE2L2 protein] |
CTD |
PMID:29289645 |
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NCBI chr20:7,818,289...7,883,482
Ensembl chr20:7,818,289...7,885,333
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G |
Pparg |
peroxisome proliferator-activated receptor gamma |
increases expression decreases activity multiple interactions |
EXP |
Fructose results in increased expression of PPARG mRNA Fructose results in decreased activity of PPARG protein [Dietary Fats co-treated with Fructose] results in decreased expression of PPARG protein; Carnitine inhibits the reaction [[Dietary Fats co-treated with Fructose] results in decreased expression of PPARG protein]; Fatty Acids, Omega-3 inhibits the reaction [[Dietary Fats co-treated with Fructose] results in decreased expression of PPARG protein]; geraniol inhibits the reaction [Fructose results in decreased activity of PPARG protein]; Metformin inhibits the reaction [[Dietary Fats co-treated with Fructose] results in decreased expression of PPARG protein]; Pioglitazone inhibits the reaction [Fructose results in decreased activity of PPARG protein]; Rosiglitazone promotes the reaction [Fructose results in increased expression of PPARG mRNA] |
CTD |
PMID:19196556 PMID:25679220 PMID:30256492 |
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NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
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G |
Ppargc1a |
PPARG coactivator 1 alpha |
decreases expression increases expression multiple interactions |
ISO EXP |
Fructose results in decreased expression of PPARGC1A mRNA Fructose results in increased expression of PPARGC1A mRNA; Fructose results in increased expression of PPARGC1A protein 2-(3-(4-ethoxybenzyl)-4-chlorophenyl)-6-hydroxymethyltetrahydro-2H-pyran-3,4,5-triol inhibits the reaction [[Fructose co-treated with Dietary Fats] results in decreased expression of PPARGC1A protein]; [Atorvastatin co-treated with 2-(3-(4-ethoxybenzyl)-4-chlorophenyl)-6-hydroxymethyltetrahydro-2H-pyran-3,4,5-triol] inhibits the reaction [[Fructose co-treated with Dietary Fats] results in decreased expression of PPARGC1A protein]; [Fructose co-treated with Dietary Fats] results in decreased expression of PPARGC1A protein; [Ozone co-treated with Fructose] results in decreased expression of PPARGC1A mRNA; [Particulate Matter co-treated with Fructose] results in decreased expression of PPARGC1A mRNA; [Particulate Matter co-treated with Ozone co-treated with Fructose] results in decreased expression of PPARGC1A mRNA; Rosiglitazone inhibits the reaction [Fructose results in increased expression of PPARGC1A protein] |
CTD |
PMID:18063403 PMID:19196556 PMID:21212096 PMID:23968387 PMID:32259528 |
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NCBI chr14:63,095,291...63,190,688
Ensembl chr14:63,095,720...63,187,009
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G |
Prdx6 |
peroxiredoxin 6 |
multiple interactions |
EXP |
[Fructose co-treated with bisphenol A] results in increased expression of PRDX6 protein |
CTD |
PMID:26930160 |
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NCBI chr13:79,077,567...79,088,113
Ensembl chr13:79,077,033...79,088,127
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G |
Prkca |
protein kinase C, alpha |
multiple interactions |
EXP |
[Atorvastatin co-treated with 2-(3-(4-ethoxybenzyl)-4-chlorophenyl)-6-hydroxymethyltetrahydro-2H-pyran-3,4,5-triol] inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of and results in increased phosphorylation of PRKCA protein]; [Fructose co-treated with Dietary Fats] results in increased expression of and results in increased phosphorylation of PRKCA protein |
CTD |
PMID:32259528 |
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NCBI chr10:96,186,509...96,585,168
Ensembl chr10:96,191,133...96,584,947
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G |
Prkcq |
protein kinase C, theta |
multiple interactions increases phosphorylation |
EXP |
Curcumin inhibits the reaction [Fructose results in increased phosphorylation of PRKCQ protein] |
CTD |
PMID:26713546 |
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NCBI chr17:70,971,915...71,105,286
Ensembl chr17:70,971,915...71,105,286
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G |
Prkcz |
protein kinase C, zeta |
multiple interactions |
EXP |
2-(3-(4-ethoxybenzyl)-4-chlorophenyl)-6-hydroxymethyltetrahydro-2H-pyran-3,4,5-triol inhibits the reaction [[Fructose co-treated with Dietary Fats] results in decreased expression of PRKCZ protein]; [Atorvastatin co-treated with 2-(3-(4-ethoxybenzyl)-4-chlorophenyl)-6-hydroxymethyltetrahydro-2H-pyran-3,4,5-triol] inhibits the reaction [[Fructose co-treated with Dietary Fats] results in decreased expression of PRKCZ protein]; [Fructose co-treated with Dietary Fats] results in decreased expression of PRKCZ protein |
CTD |
PMID:32259528 |
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NCBI chr 5:172,658,071...172,769,492
Ensembl chr 5:172,658,748...172,769,421
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G |
Pten |
phosphatase and tensin homolog |
multiple interactions increases expression |
EXP |
tributylhexadecylphosphonium bromide inhibits the reaction [Fructose results in increased expression of PTEN protein] |
CTD |
PMID:26358169 |
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NCBI chr 1:251,421,814...251,487,634
Ensembl chr 1:251,421,596...251,487,832
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G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
increases expression multiple interactions |
EXP |
Fructose results in increased expression of PTGS2 mRNA; Fructose results in increased expression of PTGS2 protein Curcumin inhibits the reaction [Fructose results in increased expression of PTGS2 protein]; Kangen-karyu inhibits the reaction [Fructose results in increased expression of PTGS2 protein]; tributylhexadecylphosphonium bromide inhibits the reaction [Fructose results in increased expression of PTGS2 protein] |
CTD |
PMID:14757778 PMID:17883899 PMID:26358169 PMID:26713546 |
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NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
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G |
Ptma |
prothymosin alpha |
multiple interactions |
EXP |
PTMA protein inhibits the reaction [Fructose results in increased expression of IL1B protein]; PTMA protein inhibits the reaction [Fructose results in increased expression of IL6 protein] |
CTD |
PMID:15885234 |
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NCBI chr 9:93,545,396...93,549,436
Ensembl chr 9:93,545,396...93,549,436
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G |
Pura |
purine rich element binding protein A |
multiple interactions |
EXP |
[Fructose co-treated with bisphenol A] results in increased expression of PURA protein |
CTD |
PMID:26930160 |
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NCBI chr18:29,104,712...29,114,918
Ensembl chr18:29,110,242...29,111,156
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G |
Pycard |
PYD and CARD domain containing |
multiple interactions increases expression |
EXP |
Allopurinol inhibits the reaction [Fructose results in increased expression of PYCARD protein]; Quercetin inhibits the reaction [Fructose results in increased expression of PYCARD protein]; Rutin inhibits the reaction [Fructose results in increased expression of PYCARD protein] |
CTD |
PMID:22426011 |
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NCBI chr 1:199,438,029...199,439,062
Ensembl chr 1:199,437,832...199,439,210
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G |
Pyy |
peptide YY |
affects expression |
EXP |
Fructose affects the expression of PYY protein |
CTD |
PMID:18627777 |
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NCBI chr10:90,047,989...90,049,155
Ensembl chr10:90,047,993...90,049,112
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G |
Rbmx |
RNA binding motif protein, X-linked |
multiple interactions |
EXP |
Fructose promotes the reaction [RBMX protein binds to SREBF1 promoter] |
CTD |
PMID:17188681 |
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NCBI chr X:159,881,835...159,891,405
Ensembl chr X:159,884,885...159,891,326
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G |
Rela |
RELA proto-oncogene, NF-kB subunit |
affects localization increases phosphorylation decreases activity multiple interactions |
EXP |
Fructose affects the localization of RELA protein Fructose results in increased phosphorylation of RELA protein Fructose results in decreased activity of RELA protein Allopurinol inhibits the reaction [Fructose results in increased phosphorylation of RELA protein]; Betaine inhibits the reaction [Fructose results in decreased activity of RELA protein]; galangin inhibits the reaction [Fructose affects the localization of RELA protein]; Genistein inhibits the reaction [Fructose affects the localization of RELA protein]; Metformin inhibits the reaction [Fructose results in increased phosphorylation of RELA protein]; Quercetin inhibits the reaction [Fructose results in increased phosphorylation of RELA protein]; resveratrol inhibits the reaction [Fructose results in increased phosphorylation of RELA protein] |
CTD |
PMID:21704028 PMID:21708140 PMID:24491314 PMID:25108154 PMID:25559852 |
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NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
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G |
Retn |
resistin |
decreases expression multiple interactions increases expression |
EXP |
Fructose results in decreased expression of RETN mRNA Metformin inhibits the reaction [Fructose results in increased expression of RETN protein]; resveratrol inhibits the reaction [Fructose results in increased expression of RETN protein] |
CTD |
PMID:11741341 PMID:25108154 |
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NCBI chr12:2,201,909...2,203,649
Ensembl chr12:2,201,891...2,204,249
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G |
Rxra |
retinoid X receptor alpha |
decreases expression |
ISO |
Fructose results in decreased expression of RXRA protein |
CTD |
PMID:28257781 |
|
NCBI chr 3:6,272,560...6,295,354
Ensembl chr 3:6,211,789...6,295,908
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G |
S100a11 |
S100 calcium binding protein A11 |
multiple interactions |
EXP |
[Fructose co-treated with bisphenol A] results in increased expression of S100A11 protein |
CTD |
PMID:26930160 |
|
NCBI chr 2:193,863,185...193,868,646
Ensembl chr 2:193,866,951...193,868,502
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G |
S100a6 |
S100 calcium binding protein A6 |
decreases expression |
EXP |
Fructose results in decreased expression of S100A6 mRNA |
CTD |
PMID:15150374 |
|
NCBI chr 2:190,007,013...190,008,512
Ensembl chr 2:190,007,216...190,008,511
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G |
Scarb1 |
scavenger receptor class B, member 1 |
decreases expression |
EXP |
Fructose results in decreased expression of SCARB1 mRNA |
CTD |
PMID:19193814 |
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NCBI chr12:36,694,952...36,761,445
Ensembl chr12:36,694,960...36,761,455
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G |
Scd |
stearoyl-CoA desaturase |
multiple interactions increases expression affects response to substance |
ISO EXP |
FGF21 gene mutant form inhibits the reaction [Fructose results in increased expression of SCD1 mRNA]; Phenylbutyrates inhibits the reaction [Fructose results in increased expression of SCD1 mRNA]; SCD1 affects the reaction [Fructose results in increased expression of SREBF1 protein]; SCD1 gene mutant form inhibits the reaction [Fructose results in increased abundance of Triglycerides]; SCD1 gene mutant form inhibits the reaction [Fructose results in increased expression of ACACA mRNA]; SCD1 gene mutant form inhibits the reaction [Fructose results in increased expression of FASN mRNA]; SCD1 gene mutant form inhibits the reaction [Fructose results in increased expression of SREBF1 mRNA]; SCD1 gene mutant form inhibits the reaction [Fructose results in increased expression of SREBF1 protein]; Triolein inhibits the reaction [SCD1 gene mutant form inhibits the reaction [Fructose results in increased abundance of Triglycerides]]; Triolein inhibits the reaction [SCD1 gene mutant form inhibits the reaction [Fructose results in increased expression of ACACA mRNA]]; Triolein inhibits the reaction [SCD1 gene mutant form inhibits the reaction [Fructose results in increased expression of FASN mRNA]]; Triolein inhibits the reaction [SCD1 gene mutant form inhibits the reaction [Fructose results in increased expression of SREBF1 mRNA]]; Triolein inhibits the reaction [SCD1 gene mutant form inhibits the reaction [Fructose results in increased expression of SREBF1 protein]] [Fructose co-treated with Copper deficiency] results in decreased expression of SCD1 mRNA; Atorvastatin inhibits the reaction [Fructose results in increased expression of SCD1 mRNA]; gadolinium chloride promotes the reaction [[Fructose co-treated with Copper deficiency] results in decreased expression of SCD1 mRNA]; Tea inhibits the reaction [Fructose results in increased expression of SCD1 mRNA] Fructose results in increased expression of SCD mRNA; Fructose results in increased expression of SCD1 mRNA Fructose results in increased expression of SCD1 mRNA; Fructose results in increased expression of SCD1 protein SCD1 affects the susceptibility to Fructose |
CTD |
PMID:7961698 PMID:15066988 PMID:18063403 PMID:19053045 PMID:19193814 PMID:21122807 PMID:22698815 PMID:25813056 PMID:28123933 |
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NCBI chr 1:264,159,966...264,173,061
Ensembl chr 1:264,160,129...264,172,729
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G |
Serpine1 |
serpin family E member 1 |
increases secretion increases expression multiple interactions |
EXP |
Fructose results in increased secretion of SERPINE1 protein Fructose results in increased expression of SERPINE1 mRNA; Fructose results in increased expression of SERPINE1 protein Atorvastatin inhibits the reaction [Fructose results in increased expression of SERPINE1 mRNA]; Metformin inhibits the reaction [Fructose results in increased expression of SERPINE1 protein]; Progesterone inhibits the reaction [Fructose results in increased expression of SERPINE1 mRNA]; Progesterone inhibits the reaction [Fructose results in increased expression of SERPINE1 protein]; Resveratrol inhibits the reaction [Fructose results in increased expression of SERPINE1 protein] |
CTD |
PMID:19165636 PMID:21122807 PMID:23016136 PMID:25108154 |
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NCBI chr12:22,641,104...22,651,482
Ensembl chr12:22,641,104...22,651,482
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G |
Sgk1 |
serum/glucocorticoid regulated kinase 1 |
increases expression multiple interactions |
ISO |
Fructose results in increased expression of SGK1 mRNA SGK1 gene affects the susceptibility to [Fructose co-treated with Sodium Chloride, Dietary] |
CTD |
PMID:16284089 |
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NCBI chr 1:24,185,451...24,302,309
Ensembl chr 1:24,185,435...24,302,298
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G |
Shbg |
sex hormone binding globulin |
multiple interactions decreases expression |
ISO |
Cerulenin inhibits the reaction [Fructose results in decreased expression of SHBG protein]; Fructose affects the reaction [NR2F1 protein binds to SHBG promoter] |
CTD |
PMID:17992261 |
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NCBI chr10:56,219,861...56,237,354
Ensembl chr10:56,219,858...56,223,245
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G |
Si |
sucrase-isomaltase |
increases expression |
ISO EXP |
Fructose results in increased expression of SI mRNA |
CTD |
PMID:10222385 PMID:11242478 PMID:17786952 |
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NCBI chr 2:170,220,794...170,301,348
Ensembl chr 2:170,221,245...170,301,348
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G |
Sirt1 |
sirtuin 1 |
multiple interactions decreases expression increases expression |
ISO EXP |
SIRT1 protein affects the reaction [Fructose results in increased expression of MYH6 mRNA] Fructose results in decreased expression of SIRT1 mRNA; Fructose results in decreased expression of SIRT1 protein [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in decreased activity of SIRT1 protein] inhibits the reaction [Fructose results in increased abundance of Cholesterol]; [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in decreased activity of SIRT1 protein] inhibits the reaction [Fructose results in increased abundance of Glucose]; [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in decreased activity of SIRT1 protein] inhibits the reaction [Fructose results in increased expression of ACACA mRNA]; [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in decreased activity of SIRT1 protein] inhibits the reaction [Fructose results in increased expression of HMGCR mRNA]; [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in decreased activity of SIRT1 protein] which results in decreased susceptibility to Fructose; [Niacinamide results in decreased activity of SIRT1 protein] inhibits the reaction [Fructose results in increased abundance of Cholesterol]; [Niacinamide results in decreased activity of SIRT1 protein] inhibits the reaction [Fructose results in increased abundance of Glucose]; [Niacinamide results in decreased activity of SIRT1 protein] inhibits the reaction [Fructose results in increased expression of ACACA mRNA]; [Niacinamide results in decreased activity of SIRT1 protein] inhibits the reaction [Fructose results in increased expression of HMGCR mRNA]; [Niacinamide results in decreased activity of SIRT1 protein] which results in decreased susceptibility to Fructose; Fructose results in increased expression of and results in increased activity of SIRT1 protein; Metformin inhibits the reaction [Fructose results in decreased expression of SIRT1 protein]; resveratrol inhibits the reaction [Fructose results in decreased expression of SIRT1 mRNA]; resveratrol inhibits the reaction [Fructose results in decreased expression of SIRT1 protein] Fructose results in increased expression of SIRT1 protein |
CTD |
PMID:18192211 PMID:21212096 PMID:25108154 PMID:26488877 |
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NCBI chr20:26,831,971...26,851,587
Ensembl chr20:26,833,357...26,852,199
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G |
Slc22a1 |
solute carrier family 22 member 1 |
multiple interactions decreases expression |
EXP |
Allopurinol inhibits the reaction [Fructose results in decreased expression of SLC22A1 mRNA]; Allopurinol inhibits the reaction [Fructose results in decreased expression of SLC22A1 protein]; Quercetin inhibits the reaction [Fructose results in decreased expression of SLC22A1 mRNA]; Quercetin inhibits the reaction [Fructose results in decreased expression of SLC22A1 protein]; Rutin inhibits the reaction [Fructose results in decreased expression of SLC22A1 mRNA]; Rutin inhibits the reaction [Fructose results in decreased expression of SLC22A1 protein] Fructose results in decreased expression of SLC22A1 mRNA; Fructose results in decreased expression of SLC22A1 protein |
CTD |
PMID:19605544 |
|
NCBI chr 1:48,273,639...48,300,645
Ensembl chr 1:48,273,611...48,300,655
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G |
Slc22a12 |
solute carrier family 22 member 12 |
increases expression multiple interactions |
EXP |
Fructose results in increased expression of SLC22A12 mRNA; Fructose results in increased expression of SLC22A12 protein Allopurinol inhibits the reaction [Fructose results in increased expression of SLC22A12 mRNA]; Allopurinol inhibits the reaction [Fructose results in increased expression of SLC22A12 protein]; Quercetin inhibits the reaction [Fructose results in increased expression of SLC22A12 mRNA]; Quercetin inhibits the reaction [Fructose results in increased expression of SLC22A12 protein]; Rutin inhibits the reaction [Fructose results in increased expression of SLC22A12 mRNA]; Rutin inhibits the reaction [Fructose results in increased expression of SLC22A12 protein] |
CTD |
PMID:19605544 |
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NCBI chr 1:221,910,787...221,919,277
Ensembl chr 1:221,910,767...221,919,301
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G |
Slc22a2 |
solute carrier family 22 member 2 |
multiple interactions decreases expression |
EXP |
Allopurinol inhibits the reaction [Fructose results in decreased expression of SLC22A2 mRNA]; Allopurinol inhibits the reaction [Fructose results in decreased expression of SLC22A2 protein]; Quercetin inhibits the reaction [Fructose results in decreased expression of SLC22A2 mRNA]; Quercetin inhibits the reaction [Fructose results in decreased expression of SLC22A2 protein]; Rutin inhibits the reaction [Fructose results in decreased expression of SLC22A2 mRNA]; Rutin inhibits the reaction [Fructose results in decreased expression of SLC22A2 protein] Fructose results in decreased expression of SLC22A2 mRNA; Fructose results in decreased expression of SLC22A2 protein |
CTD |
PMID:19605544 |
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NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
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G |
Slc22a5 |
solute carrier family 22 member 5 |
decreases expression multiple interactions |
EXP |
Fructose results in decreased expression of SLC22A5 protein Allopurinol inhibits the reaction [Fructose results in decreased expression of SLC22A5 protein]; Quercetin inhibits the reaction [Fructose results in decreased expression of SLC22A5 protein] |
CTD |
PMID:22426011 |
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NCBI chr10:39,201,101...39,228,090
Ensembl chr10:39,201,107...39,323,853
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G |
Slc22a6 |
solute carrier family 22 member 6 |
multiple interactions decreases expression |
EXP |
Allopurinol inhibits the reaction [Fructose results in decreased expression of SLC22A6 mRNA]; Allopurinol inhibits the reaction [Fructose results in decreased expression of SLC22A6 protein]; Quercetin inhibits the reaction [Fructose results in decreased expression of SLC22A6 mRNA]; Quercetin inhibits the reaction [Fructose results in decreased expression of SLC22A6 protein]; Rutin inhibits the reaction [Fructose results in decreased expression of SLC22A6 mRNA]; Rutin inhibits the reaction [Fructose results in decreased expression of SLC22A6 protein] Fructose results in decreased expression of SLC22A6 mRNA; Fructose results in decreased expression of SLC22A6 protein |
CTD |
PMID:19605544 |
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NCBI chr 1:224,824,809...224,833,284
Ensembl chr 1:224,824,799...224,833,259
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G |
Slc25a5 |
solute carrier family 25 member 5 |
multiple interactions |
EXP |
[Fructose co-treated with bisphenol A] results in decreased expression of SLC25A5 protein |
CTD |
PMID:26930160 |
|
NCBI chr X:123,404,570...123,407,637
Ensembl chr X:123,404,518...123,407,645
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G |
Slc27a2 |
solute carrier family 27 member 2 |
decreases expression |
ISO |
Fructose results in decreased expression of SLC27A2 protein |
CTD |
PMID:28257781 |
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NCBI chr 3:119,014,620...119,052,531
Ensembl chr 3:119,014,620...119,052,531
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G |
Slc2a2 |
solute carrier family 2 member 2 |
multiple interactions increases expression increases transport |
ISO EXP |
Fructose inhibits the reaction [SLC2A2 protein results in increased transport of Deoxyglucose]; Glucose inhibits the reaction [SLC2A2 protein results in increased transport of Fructose]; Maltose inhibits the reaction [SLC2A2 protein results in increased transport of Fructose] Fructose results in increased expression of SLC2A2 mRNA Dactinomycin inhibits the reaction [Fructose results in increased expression of SLC2A2 mRNA] Fructose results in increased expression of and affects the localization of SLC2A2 protein |
CTD |
PMID:1727734 PMID:8457197 PMID:10222385 PMID:12787936 PMID:12937289 PMID:17710649 PMID:17786952 |
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NCBI chr 2:114,413,427...114,445,418
Ensembl chr 2:114,413,410...114,445,395
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G |
Slc2a4 |
solute carrier family 2 member 4 |
decreases expression multiple interactions increases expression |
ISO EXP |
Fructose results in decreased expression of SLC2A4 mRNA [Dietary Fats co-treated with Fructose] results in decreased expression of SLC2A4 protein; Carnitine inhibits the reaction [[Dietary Fats co-treated with Fructose] results in decreased expression of SLC2A4 protein]; Fatty Acids, Omega-3 inhibits the reaction [[Dietary Fats co-treated with Fructose] results in decreased expression of SLC2A4 protein]; Metformin inhibits the reaction [[Dietary Fats co-treated with Fructose] results in decreased expression of SLC2A4 protein] Fructose results in increased expression of SLC2A4 mRNA |
CTD |
PMID:15111496 PMID:18063403 PMID:30256492 |
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NCBI chr10:56,552,921...56,558,562
Ensembl chr10:56,552,983...56,558,487
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G |
Slc2a5 |
solute carrier family 2 member 5 |
multiple interactions increases activity increases expression increases transport increases uptake affects expression |
ISO EXP |
[Fructose results in increased abundance of Cyclic AMP] which results in increased stability of SLC2A5 mRNA; Colforsin promotes the reaction [Fructose results in increased expression of SLC2A5 mRNA]; Fructose promotes the reaction [PAIP2 protein binds to SLC2A5 3' UTR] Fructose results in increased activity of SLC2A5 protein SLC2A5 protein results in increased transport of Fructose Fructose results in increased expression of SLC2A5 mRNA; Fructose results in increased expression of SLC2A5 protein SLC2A5 protein results in increased uptake of Fructose Fructose affects the expression of SLC2A5 mRNA Fructose analog results in increased expression of SLC2A5 mRNA; Fructose results in increased expression of SLC2A5 mRNA; Fructose results in increased expression of SLC2A5 protein 1-((1-O-octadecyl-2-O-methylglycero)phospho)-3-deoxy-myo-inositol inhibits the reaction [Fructose results in increased expression of and results in increased activity of SLC2A5 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Fructose results in increased expression of and results in increased activity of SLC2A5 protein]; [[Colforsin results in increased abundance of Cyclic AMP] which results in increased expression of SLC2A5 protein] which results in increased uptake of Fructose; [Triiodothyronine co-treated with Fructose] results in increased expression of SLC2A5 mRNA; Cycloheximide inhibits the reaction [Fructose promotes the reaction [SLC2A5 protein results in increased uptake of Fructose]]; Dactinomycin inhibits the reaction [Fructose promotes the reaction [SLC2A5 protein results in increased uptake of Fructose]]; Dactinomycin inhibits the reaction [Fructose results in increased expression of SLC2A5 mRNA]; Dexamethasone promotes the reaction [Fructose results in increased activity of SLC2A5 protein]; Dexamethasone promotes the reaction [Fructose results in increased expression of SLC2A5 mRNA]; Fructose analog results in increased activity of [SLC2A5 protein results in increased uptake of Fructose]; Fructose promotes the reaction [SLC2A5 protein results in increased transport of Fructose]; Fructose promotes the reaction [SLC2A5 protein results in increased uptake of Fructose]; Fructose results in increased expression of and results in increased activity of SLC2A5 protein; Mifepristone inhibits the reaction [Dexamethasone promotes the reaction [Fructose results in increased activity of SLC2A5 protein]]; Mifepristone inhibits the reaction [Dexamethasone promotes the reaction [Fructose results in increased expression of SLC2A5 mRNA]]; Vanadates inhibits the reaction [Fructose results in increased activity of SLC2A5 protein]; Vanadates inhibits the reaction [Fructose results in increased expression of SLC2A5 mRNA]; wortmannin inhibits the reaction [Fructose results in increased expression of and results in increased activity of SLC2A5 protein] lactisole inhibits the reaction [Fructose results in increased expression of SLC2A5 mRNA] |
CTD |
PMID:1634504 PMID:8037665 PMID:8048533 PMID:8404647 PMID:8554516 PMID:9078534 PMID:9124564 PMID:9486174 PMID:9606981 PMID:10222385 PMID:10554124 PMID:11123204 PMID:11242478 PMID:11518678 PMID:12031501 PMID:12820898 PMID:12937289 PMID:15150374 PMID:15226456 PMID:15457374 PMID:15691865 PMID:16581195 PMID:16920846 PMID:16960373 PMID:17485832 PMID:17710649 PMID:17786952 PMID:18400728 PMID:18556366 PMID:19907007 |
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NCBI chr 5:167,142,182...167,174,203
Ensembl chr 5:167,141,875...167,174,310
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G |
Slc2a7 |
solute carrier family 2 member 7 |
increases transport |
ISO |
SLC2A7 protein results in increased transport of Fructose |
CTD |
PMID:15033637 PMID:17710649 |
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NCBI chr 5:167,195,981...167,211,613
Ensembl chr 5:167,195,981...167,211,391
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G |
Slc2a9 |
solute carrier family 2 member 9 |
increases transport increases expression multiple interactions |
ISO EXP |
SLC2A9 protein results in increased transport of Fructose Fructose results in increased expression of SLC2A9 mRNA SNP; Fructose results in increased expression of SLC2A9 protein SNP Allopurinol inhibits the reaction [Fructose results in increased expression of SLC2A9 mRNA SNP]; Allopurinol inhibits the reaction [Fructose results in increased expression of SLC2A9 protein SNP]; Quercetin inhibits the reaction [Fructose results in increased expression of SLC2A9 mRNA SNP]; Quercetin inhibits the reaction [Fructose results in increased expression of SLC2A9 protein SNP]; Rutin inhibits the reaction [Fructose results in increased expression of SLC2A9 mRNA SNP]; Rutin inhibits the reaction [Fructose results in increased expression of SLC2A9 protein SNP] Fructose promotes the reaction [SLC2A9 protein alternative form results in increased transport of Uric Acid] |
CTD |
PMID:17710649 PMID:18842065 PMID:19605544 |
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NCBI chr14:77,067,537...77,192,702
Ensembl chr14:77,067,503...77,192,702
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G |
Slc31a1 |
solute carrier family 31 member 1 |
multiple interactions |
EXP |
Fructose inhibits the reaction [Copper deficiency results in increased expression of SLC31A1 protein] |
CTD |
PMID:21781943 |
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NCBI chr 5:78,222,504...78,249,358
Ensembl chr 5:78,222,504...78,249,358
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G |
Slc34a2 |
solute carrier family 34 member 2 |
decreases expression multiple interactions affects expression |
EXP |
Fructose results in decreased expression of SLC34A2 mRNA tungstate promotes the reaction [Fructose results in decreased expression of SLC34A2 mRNA]; Vanadates promotes the reaction [Fructose results in decreased expression of SLC34A2 mRNA] Fructose affects the expression of SLC34A2 mRNA |
CTD |
PMID:15150374 PMID:18400728 |
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NCBI chr14:60,257,211...60,276,516
Ensembl chr14:60,256,712...60,276,794
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G |
Slc37a4 |
solute carrier family 37 member 4 |
increases expression |
EXP |
Fructose results in increased expression of SLC37A4 mRNA |
CTD |
PMID:16920846 |
|
NCBI chr 8:48,716,914...48,723,024
Ensembl chr 8:48,716,939...48,723,024
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G |
Slc46a1 |
solute carrier family 46 member 1 |
multiple interactions |
EXP |
[Folic Acid affects the susceptibility to Fructose] which affects the expression of SLC46A1 mRNA |
CTD |
PMID:31612177 |
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NCBI chr10:65,728,508...65,741,708
Ensembl chr10:65,733,991...65,740,828
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G |
Slc5a1 |
solute carrier family 5 member 1 |
multiple interactions increases expression |
ISO EXP |
lactisole inhibits the reaction [Fructose results in increased expression of SLC5A1 mRNA] Fructose results in increased expression of SLC5A1 mRNA; Fructose results in increased expression of SLC5A1 protein |
CTD |
PMID:8048533 PMID:10222385 PMID:11242478 PMID:12937289 PMID:17786952 |
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NCBI chr14:82,910,448...82,975,303
Ensembl chr14:82,909,981...82,975,263
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G |
Slc8a1 |
solute carrier family 8 member A1 |
multiple interactions |
ISO |
[Fructose co-treated with Dietary Fats] results in decreased expression of SLC8A1 mRNA; troxerutin inhibits the reaction [[Fructose co-treated with Dietary Fats] results in decreased expression of SLC8A1 mRNA] |
CTD |
PMID:28916335 |
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NCBI chr 6:4,244,076...4,564,262
Ensembl chr 6:4,258,991...4,520,604
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G |
Soat2 |
sterol O-acyltransferase 2 |
decreases expression |
EXP |
Fructose results in decreased expression of SOAT2 mRNA |
CTD |
PMID:19193814 |
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NCBI chr 7:143,754,892...143,767,989
Ensembl chr 7:143,754,892...143,767,989
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G |
Socs3 |
suppressor of cytokine signaling 3 |
increases expression multiple interactions |
EXP |
Fructose results in increased expression of SOCS3 mRNA; Fructose results in increased expression of SOCS3 protein [Fenofibrate co-treated with Resveratrol] inhibits the reaction [Fructose results in increased expression of SOCS3 mRNA]; Fenofibrate inhibits the reaction [Fructose results in increased expression of SOCS3 mRNA]; Quercetin inhibits the reaction [Fructose results in increased expression of SOCS3 protein]; Resveratrol inhibits the reaction [Fructose results in increased expression of SOCS3 mRNA]; Rutin inhibits the reaction [Fructose results in increased expression of SOCS3 protein] |
CTD |
PMID:21122807 PMID:22426011 PMID:23533474 PMID:26973390 |
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NCBI chr10:106,973,863...106,976,969
Ensembl chr10:106,975,178...106,976,040
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G |
Sod1 |
superoxide dismutase 1 |
affects binding decreases expression multiple interactions decreases activity increases activity |
ISO EXP |
Fructose binds to SOD1 protein mutant form Fructose results in decreased expression of SOD1 mRNA; Fructose results in decreased expression of SOD1 protein [Fructose co-treated with Copper deficiency] results in decreased expression of SOD1 protein Fructose results in decreased activity of SOD1 protein Fructose results in increased activity of SOD1 protein Fructose promotes the reaction [SOD1 protein mutant form results in increased chemical synthesis of Hydrogen Peroxide] |
CTD |
PMID:11817707 PMID:12626432 PMID:16815490 PMID:20470786 PMID:21781943 |
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NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
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G |
Sord |
sorbitol dehydrogenase |
multiple interactions increases glycation |
EXP ISO |
[Fructose results in increased glycation of SORD protein] which results in decreased activity of SORD protein [SORD protein results in increased metabolism of Sorbitol] which results in increased abundance of Fructose |
CTD |
PMID:8761460 PMID:32367058 |
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NCBI chr 3:114,176,127...114,207,368
Ensembl chr 3:114,176,309...114,207,366
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G |
Srebf1 |
sterol regulatory element binding transcription factor 1 |
multiple interactions increases expression affects localization affects response to substance |
ISO EXP |
Phenylbutyrates inhibits the reaction [Fructose affects the localization of SREBF1 protein alternative form]; Phenylbutyrates inhibits the reaction [Fructose results in increased expression of SREBF1 mRNA]; SCD1 affects the reaction [Fructose results in increased expression of SREBF1 protein]; SCD1 gene mutant form inhibits the reaction [Fructose results in increased expression of SREBF1 mRNA]; SCD1 gene mutant form inhibits the reaction [Fructose results in increased expression of SREBF1 protein]; Triolein inhibits the reaction [SCD1 gene mutant form inhibits the reaction [Fructose results in increased expression of SREBF1 mRNA]]; Triolein inhibits the reaction [SCD1 gene mutant form inhibits the reaction [Fructose results in increased expression of SREBF1 protein]] Fructose results in increased expression of SREBF1 mRNA; Fructose results in increased expression of SREBF1 protein 2-(3-(4-ethoxybenzyl)-4-chlorophenyl)-6-hydroxymethyltetrahydro-2H-pyran-3,4,5-triol inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of SREBF1 protein]; [Atorvastatin co-treated with 2-(3-(4-ethoxybenzyl)-4-chlorophenyl)-6-hydroxymethyltetrahydro-2H-pyran-3,4,5-triol] inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of SREBF1 protein]; [Fenofibrate co-treated with Resveratrol] inhibits the reaction [Fructose results in increased expression of SREBF1 mRNA]; [Fructose co-treated with Copper deficiency] results in increased expression of SREBF1 protein; [Fructose co-treated with Dietary Fats] results in increased expression of SREBF1 protein; Atorvastatin inhibits the reaction [Fructose results in increased activity of SREBF1 protein]; Fructose promotes the reaction [RBMX protein binds to SREBF1 promoter]; Fructose results in increased expression of and results in increased activity of SREBF1 protein; gadolinium chloride inhibits the reaction [[Fructose co-treated with Copper deficiency] results in increased expression of SREBF1 protein]; Resveratrol inhibits the reaction [Fructose results in increased expression of SREBF1 mRNA]; Rosiglitazone inhibits the reaction [Fructose results in increased expression of SREBF1 mRNA]; Tea inhibits the reaction [Fructose results in increased expression of SREBF1 mRNA] SREBF1 promoter SNP affects the susceptibility to Fructose |
CTD |
PMID:10913129 PMID:11934685 PMID:15066988 PMID:15123654 PMID:17188681 PMID:18346472 PMID:19053045 PMID:19193814 PMID:19196556 PMID:19799862 PMID:22698815 PMID:25813056 PMID:26973390 PMID:32259528 |
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NCBI chr10:46,570,996...46,593,021
Ensembl chr10:46,570,996...46,593,009
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G |
Stat3 |
signal transducer and activator of transcription 3 |
increases phosphorylation decreases phosphorylation multiple interactions |
EXP |
Fructose results in increased phosphorylation of STAT3 protein Fructose results in decreased phosphorylation of STAT3 protein Quercetin inhibits the reaction [Fructose results in decreased phosphorylation of STAT3 protein]; Quercetin inhibits the reaction [Fructose results in increased phosphorylation of STAT3 protein]; Rutin inhibits the reaction [Fructose results in increased phosphorylation of STAT3 protein] |
CTD |
PMID:22426011 PMID:23533474 |
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NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233
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G |
Steap4 |
STEAP4 metalloreductase |
multiple interactions |
EXP |
[Dietary Fats co-treated with Fructose] results in increased expression of STEAP4 mRNA |
CTD |
PMID:19632207 |
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NCBI chr 4:23,112,682...23,135,354
Ensembl chr 4:23,090,029...23,135,354
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G |
Tfam |
transcription factor A, mitochondrial |
increases expression |
EXP |
Fructose results in increased expression of TFAM protein |
CTD |
PMID:11934685 |
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NCBI chr20:18,594,057...18,606,106
Ensembl chr20:18,594,037...18,606,151
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G |
Tgfb1 |
transforming growth factor, beta 1 |
decreases expression multiple interactions increases expression |
EXP ISO |
Fructose results in decreased expression of TGFB1 mRNA [FGF21 gene mutant form results in increased susceptibility to Fructose] which results in increased expression of TGFB1 mRNA Fructose results in increased expression of TGFB1 mRNA; Fructose results in increased expression of TGFB1 protein 2-(3-(4-ethoxybenzyl)-4-chlorophenyl)-6-hydroxymethyltetrahydro-2H-pyran-3,4,5-triol inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of and results in increased secretion of TGFB1 protein]; 2-(3-(4-ethoxybenzyl)-4-chlorophenyl)-6-hydroxymethyltetrahydro-2H-pyran-3,4,5-triol promotes the reaction [Metformin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of and results in increased secretion of TGFB1 protein]]; [Fenofibrate co-treated with Resveratrol] inhibits the reaction [Fructose results in increased expression of TGFB1 mRNA]; [Streptozocin co-treated with Fructose] results in increased expression of and results in increased secretion of TGFB1 protein; betanin inhibits the reaction [Fructose results in increased expression of TGFB1 protein]; Fenofibrate inhibits the reaction [Fructose results in increased expression of TGFB1 mRNA]; galangin inhibits the reaction [Fructose results in increased expression of TGFB1 protein]; Genistein inhibits the reaction [Fructose results in increased expression of TGFB1 protein]; Metformin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of and results in increased secretion of TGFB1 protein]; Resveratrol inhibits the reaction [Fructose results in increased expression of TGFB1 mRNA] |
CTD |
PMID:15150374 PMID:21704028 PMID:21708140 PMID:25559852 PMID:26973390 PMID:28123933 PMID:30551545 |
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NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
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G |
Tgfb2 |
transforming growth factor, beta 2 |
multiple interactions |
ISO |
[FGF21 gene mutant form results in increased susceptibility to Fructose] which results in increased expression of TGFB2 mRNA |
CTD |
PMID:28123933 |
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NCBI chr13:105,039,639...105,142,010
Ensembl chr13:105,039,853...105,141,030
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G |
Th |
tyrosine hydroxylase |
increases expression |
ISO |
Fructose results in increased expression of TH mRNA |
CTD |
PMID:16843071 |
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NCBI chr 1:216,073,034...216,080,287
Ensembl chr 1:216,073,031...216,080,287
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G |
Thrsp |
thyroid hormone responsive |
multiple interactions |
EXP |
Fructose inhibits the reaction [Streptozocin results in decreased expression of THRSP mRNA] |
CTD |
PMID:2177838 |
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NCBI chr 1:162,381,251...162,385,575
Ensembl chr 1:162,381,253...162,385,575
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G |
Tlr4 |
toll-like receptor 4 |
multiple interactions increases expression |
EXP ISO |
[gadolinium chloride co-treated with Fructose co-treated with Copper deficiency] results in decreased expression of TLR4 mRNA Fructose results in increased expression of TLR4 protein [Fructose co-treated with Ethanol] results in increased expression of TLR4 mRNA |
CTD |
PMID:25813056 PMID:26858005 PMID:31672515 |
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NCBI chr 5:82,587,424...82,601,056
Ensembl chr 5:82,587,420...82,601,052
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G |
Tnf |
tumor necrosis factor |
multiple interactions increases secretion increases expression |
EXP ISO |
2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [caryophyllene inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of TNF protein]]; 2-(3-(4-ethoxybenzyl)-4-chlorophenyl)-6-hydroxymethyltetrahydro-2H-pyran-3,4,5-triol inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of and results in increased secretion of TNF protein]; 2-(3-(4-ethoxybenzyl)-4-chlorophenyl)-6-hydroxymethyltetrahydro-2H-pyran-3,4,5-triol promotes the reaction [Metformin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of and results in increased secretion of TNF protein]]; [Dietary Fats co-treated with Fructose] results in increased expression of TNF protein; [Fenofibrate co-treated with Resveratrol] inhibits the reaction [Fructose results in increased expression of and results in increased secretion of TNF protein]; [gadolinium chloride co-treated with Fructose co-treated with Copper deficiency] results in decreased expression of TNF mRNA; [Particulate Matter co-treated with Ozone] promotes the reaction [Fructose results in increased expression of TNF mRNA]; [Streptozocin co-treated with Fructose] results in increased expression of and results in increased secretion of TNF protein; Allopurinol inhibits the reaction [Fructose results in increased expression of TNF protein]; caffeic acid phenethyl ester inhibits the reaction [Fructose results in increased expression of TNF protein]; caryophyllene inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of TNF protein]; Curcumin inhibits the reaction [Fructose results in increased expression of TNF protein]; Fenofibrate inhibits the reaction [Fructose results in increased expression of and results in increased secretion of TNF protein]; Fructose inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of TNF protein]; Fructose results in increased expression of and results in increased secretion of TNF protein; galangin inhibits the reaction [Fructose results in increased expression of TNF mRNA]; galangin inhibits the reaction [Fructose results in increased expression of TNF protein]; Genistein inhibits the reaction [Fructose results in increased expression of TNF protein]; geraniol inhibits the reaction [Fructose results in increased secretion of TNF protein]; iodopravadoline inhibits the reaction [caryophyllene inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of TNF protein]]; Metformin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of and results in increased secretion of TNF protein]; Metformin inhibits the reaction [Fructose results in increased expression of TNF protein]; Ozone promotes the reaction [Fructose results in increased expression of TNF mRNA]; Particulate Matter promotes the reaction [Fructose results in increased expression of TNF mRNA]; Pioglitazone inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of TNF protein]; Pioglitazone inhibits the reaction [Fructose results in increased secretion of TNF protein]; Quercetin inhibits the reaction [Fructose results in increased expression of TNF protein]; Resveratrol inhibits the reaction [Fructose results in increased expression of and results in increased secretion of TNF protein]; Resveratrol inhibits the reaction [Fructose results in increased expression of TNF protein]; Rutin inhibits the reaction [Fructose results in increased expression of TNF protein]; tributylhexadecylphosphonium bromide inhibits the reaction [Fructose results in increased expression of TNF protein] Fructose promotes the reaction [Ethanol results in increased expression of TNF mRNA] Fructose results in increased expression of TNF mRNA; Fructose results in increased expression of TNF protein |
CTD |
PMID:10090849 PMID:21704028 PMID:21708140 PMID:22426011 PMID:23968387 PMID:24508943 PMID:25108154 PMID:25679220 PMID:25813056 PMID:26358169 PMID:26713546 PMID:26858005 PMID:26973390 PMID:27531227 PMID:28257781 PMID:30343038 PMID:30551545 PMID:31672515 |
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NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000 Ensembl chr20:5,189,390...5,192,000
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G |
Traf6 |
TNF receptor associated factor 6 |
multiple interactions |
ISO |
Fructose inhibits the reaction [Ethanol results in increased expression of TRAF6 protein]; Fructose promotes the reaction [Ethanol results in increased expression of TRAF6 mRNA] |
CTD |
PMID:26858005 |
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NCBI chr 3:91,252,829...91,271,607
Ensembl chr 3:91,252,829...91,271,607
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G |
Trap1 |
TNF receptor-associated protein 1 |
multiple interactions decreases expression |
EXP |
[Fructose co-treated with bisphenol A] results in increased expression of TRAP1 protein Fructose results in decreased expression of TRAP1 protein |
CTD |
PMID:26930160 |
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NCBI chr10:11,724,032...11,757,682
Ensembl chr10:11,724,032...11,757,681
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G |
Trib3 |
tribbles pseudokinase 3 |
increases expression multiple interactions |
EXP ISO |
Fructose results in increased expression of TRIB3 mRNA Phenylbutyrates inhibits the reaction [Fructose results in increased expression of TRIB3 mRNA] |
CTD |
PMID:18497449 PMID:22698815 |
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NCBI chr 3:147,814,056...147,819,650
Ensembl chr 3:147,813,473...147,819,571
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G |
Ttr |
transthyretin |
multiple interactions |
EXP |
[Fructose co-treated with bisphenol A] results in increased expression of TTR protein |
CTD |
PMID:26930160 |
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NCBI chr18:15,532,963...15,542,180
Ensembl chr18:15,532,963...15,540,177
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G |
Txnip |
thioredoxin interacting protein |
increases expression multiple interactions |
EXP |
Fructose results in increased expression of TXNIP protein Allopurinol inhibits the reaction [Fructose results in increased expression of TXNIP protein]; Quercetin inhibits the reaction [Fructose results in increased expression of TXNIP protein] |
CTD |
PMID:24491314 |
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NCBI chr 2:198,683,168...198,686,971
Ensembl chr 2:198,683,159...198,686,974
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G |
Ucp1 |
uncoupling protein 1 |
multiple interactions decreases expression |
EXP |
Fructose promotes the reaction [[Ozone co-treated with Particulate Matter] results in decreased expression of UCP1 mRNA]; Fructose promotes the reaction [Ozone results in decreased expression of UCP1 mRNA]; Fructose promotes the reaction [Particulate Matter results in decreased expression of UCP1 mRNA] Fructose results in decreased expression of UCP1 mRNA |
CTD |
PMID:23968387 |
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NCBI chr19:24,456,976...24,464,808
Ensembl chr19:24,456,976...24,464,807
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G |
Ucp3 |
uncoupling protein 3 |
increases expression |
EXP |
Fructose results in increased expression of UCP3 protein |
CTD |
PMID:11934685 |
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NCBI chr 1:165,482,912...165,495,895
Ensembl chr 1:165,482,155...165,496,206
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G |
Vcam1 |
vascular cell adhesion molecule 1 |
increases expression multiple interactions |
EXP ISO |
Fructose results in increased expression of VCAM1 mRNA 2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [caryophyllene inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of VCAM1 protein]]; [Dietary Fats co-treated with Fructose] results in increased expression of VCAM1 protein; caryophyllene inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of VCAM1 protein]; iodopravadoline inhibits the reaction [caryophyllene inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of VCAM1 protein]]; Pioglitazone inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of VCAM1 protein] |
CTD |
PMID:17587757 PMID:30343038 PMID:31655124 |
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NCBI chr 2:219,071,193...219,090,931
Ensembl chr 2:219,071,193...219,097,619
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G |
Vcl |
vinculin |
multiple interactions decreases expression |
EXP |
[Fructose co-treated with bisphenol A] results in decreased expression of VCL protein Fructose results in decreased expression of VCL protein |
CTD |
PMID:26930160 |
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NCBI chr15:3,455,211...3,544,738
Ensembl chr15:3,455,211...3,544,702
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G |
Vegfa |
vascular endothelial growth factor A |
multiple interactions |
EXP |
[bisphenol A co-treated with Fructose] results in increased expression of VEGFA mRNA |
CTD |
PMID:27622962 |
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NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
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G |
Vldlr |
very low density lipoprotein receptor |
multiple interactions |
ISO |
[PPARD mRNA results in decreased susceptibility to Fructose] which results in decreased expression of VLDLR mRNA; Fructose inhibits the reaction [PPARD mRNA results in decreased expression of VLDLR mRNA]; Fructose promotes the reaction [PPARD gene mutant form results in increased expression of VLDLR mRNA]; Fructose promotes the reaction [PPARD gene mutant form results in increased expression of VLDLR protein] |
CTD |
PMID:29289645 |
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NCBI chr 1:245,236,819...245,273,688
Ensembl chr 1:245,237,736...245,269,205
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G |
Vnn1 |
vanin 1 |
multiple interactions |
EXP |
2-(3-(4-ethoxybenzyl)-4-chlorophenyl)-6-hydroxymethyltetrahydro-2H-pyran-3,4,5-triol inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of VNN1 mRNA]; [Streptozocin co-treated with Fructose] results in increased expression of VNN1 mRNA; Metformin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of VNN1 mRNA] |
CTD |
PMID:30551545 |
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NCBI chr 1:22,614,832...22,625,134
Ensembl chr 1:22,614,783...22,625,204
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G |
Xbp1 |
X-box binding protein 1 |
affects localization |
ISO |
Fructose affects the localization of XBP1 protein |
CTD |
PMID:22698815 |
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NCBI chr14:85,753,736...85,758,820
Ensembl chr14:85,753,760...85,758,145
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G |
Xdh |
xanthine dehydrogenase |
multiple interactions increases activity |
ISO EXP |
Fructose promotes the reaction [XDH protein results in increased chemical synthesis of Uric Acid]; XDH protein promotes the reaction [Fructose results in increased abundance of Reactive Oxygen Species] Glutamine inhibits the reaction [Fructose results in increased activity of XDH protein] |
CTD |
PMID:19158351 PMID:31233715 |
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NCBI chr 6:25,149,570...25,211,273
Ensembl chr 6:25,149,235...25,211,494
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G |
Ybx3 |
Y box binding protein 3 |
multiple interactions |
EXP |
[Fructose co-treated with bisphenol A] results in increased expression of YBX3 protein |
CTD |
PMID:26930160 |
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NCBI chr 4:165,606,819...165,630,041
Ensembl chr 4:165,606,819...165,630,118
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G |
Gapdh |
glyceraldehyde-3-phosphate dehydrogenase |
multiple interactions |
EXP |
[GAPDH protein co-treated with fructose-1,6-diphosphate co-treated with NAD] results in increased chemical synthesis of sodium arsenite; [GAPDH protein co-treated with fructose-1,6-diphosphate co-treated with NAD] results in increased reduction of sodium arsenate analog; heptelidic acid inhibits the reaction [[GAPDH protein co-treated with fructose-1,6-diphosphate co-treated with NAD] results in increased reduction of sodium arsenate analog] |
CTD |
PMID:15788719 |
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NCBI chr 4:157,676,336...157,680,322
Ensembl chr 4:157,676,595...157,679,962
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G |
Idh2 |
isocitrate dehydrogenase (NADP(+)) 2 |
multiple interactions increases abundance |
ISO |
Triazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of fructose-1,6-diphosphate] |
CTD |
PMID:27469509 |
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NCBI chr 1:141,874,354...141,893,674
Ensembl chr 1:141,866,283...141,893,705
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G |
Mapk1 |
mitogen activated protein kinase 1 |
multiple interactions |
ISO |
fructose-1,6-diphosphate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein] |
CTD |
PMID:22227475 |
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NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
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G |
Mapk3 |
mitogen activated protein kinase 3 |
multiple interactions |
ISO |
fructose-1,6-diphosphate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein] |
CTD |
PMID:22227475 |
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NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
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G |
Nos2 |
nitric oxide synthase 2 |
multiple interactions decreases degradation |
ISO |
fructose-1,6-diphosphate inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; fructose-1,6-diphosphate inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] fructose-1,6-diphosphate results in decreased degradation of NOS2 mRNA |
CTD |
PMID:22227475 |
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NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
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G |
Ccl2 |
C-C motif chemokine ligand 2 |
multiple interactions |
ISO |
psicose inhibits the reaction [Glucose results in increased expression of CCL2 mRNA]; psicose inhibits the reaction [Glucose results in increased expression of CCL2 protein] |
CTD |
PMID:17655880 |
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NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
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G |
Bcl2 |
BCL2, apoptosis regulator |
multiple interactions |
ISO |
royal jelly inhibits the reaction [Nicotine results in decreased expression of BCL2 mRNA] |
CTD |
PMID:30896085 |
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NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
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G |
Casp3 |
caspase 3 |
multiple interactions |
ISO |
royal jelly inhibits the reaction [Nicotine results in increased expression of CASP3 mRNA] |
CTD |
PMID:30896085 |
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NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
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G |
Cat |
catalase |
multiple interactions |
EXP ISO |
royal jelly inhibits the reaction [Cisplatin results in decreased activity of CAT protein] royal jelly inhibits the reaction [Nicotine results in decreased activity of CAT protein] |
CTD |
PMID:20369241 PMID:30896085 |
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NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
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G |
Esr1 |
estrogen receptor 1 |
multiple interactions increases activity affects binding |
ISO |
Estradiol inhibits the reaction [royal jelly binds to ESR1 protein]; royal jelly binds to and results in increased activity of ESR1 protein; royal jelly inhibits the reaction [Estradiol binds to ESR1 protein] royal jelly results in increased activity of ESR1 protein |
CTD |
PMID:15946813 PMID:17287592 |
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NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
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G |
Esr2 |
estrogen receptor 2 |
multiple interactions affects binding |
ISO |
Estradiol inhibits the reaction [royal jelly binds to ESR2 protein]; royal jelly binds to and results in increased activity of ESR2 protein; royal jelly inhibits the reaction [Estradiol binds to ESR2 protein] |
CTD |
PMID:15946813 PMID:17287592 |
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NCBI chr 6:99,163,953...99,214,711
Ensembl chr 6:99,164,357...99,214,251
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G |
Pcna |
proliferating cell nuclear antigen |
multiple interactions |
ISO |
royal jelly inhibits the reaction [Nicotine results in decreased expression of PCNA protein] |
CTD |
PMID:30896085 |
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NCBI chr 3:124,880,698...124,884,570
Ensembl chr 3:124,880,698...124,884,570
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G |
Tff1 |
trefoil factor 1 |
increases expression |
ISO |
royal jelly results in increased expression of TFF1 mRNA |
CTD |
PMID:15946813 |
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NCBI chr20:9,892,124...9,895,984
Ensembl chr20:9,892,124...9,895,984
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G |
Tp53 |
tumor protein p53 |
multiple interactions |
ISO |
royal jelly inhibits the reaction [Nicotine results in increased expression of TRP53 mRNA] |
CTD |
PMID:30896085 |
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NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
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G |
Vegfa |
vascular endothelial growth factor A |
increases expression |
ISO EXP |
royal jelly results in increased expression of VEGFA mRNA |
CTD |
PMID:15946813 PMID:17287592 |
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NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
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G |
Oat |
ornithine aminotransferase |
multiple interactions decreases activity |
EXP |
Sorbose inhibits the reaction [Cyclic AMP results in increased activity of OAT protein] Sorbose results in decreased activity of OAT protein |
CTD |
PMID:2827574 |
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NCBI chr 1:204,562,289...204,582,070
Ensembl chr 1:204,562,289...204,582,070
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G |
Ccl2 |
C-C motif chemokine ligand 2 |
increases secretion |
ISO |
tagatose results in increased secretion of CCL2 protein |
CTD |
PMID:19158351 |
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NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
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G |
Abcb1a |
ATP binding cassette subfamily B member 1A |
multiple interactions increases expression |
EXP |
Amino Acids, Peptides, and Proteins inhibits the reaction [topiramate results in increased expression of ABCB1 protein] |
CTD |
PMID:18473823 |
|
NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
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G |
Abcc1 |
ATP binding cassette subfamily C member 1 |
increases expression |
EXP |
topiramate results in increased expression of ABCC1 protein |
CTD |
PMID:18473823 |
|
NCBI chr10:549,537...672,235
Ensembl chr10:549,883...672,196
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G |
Abcc2 |
ATP binding cassette subfamily C member 2 |
increases expression |
EXP |
topiramate results in increased expression of ABCC2 protein |
CTD |
PMID:18473823 |
|
NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252
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G |
Acadsb |
acyl-CoA dehydrogenase, short/branched chain |
increases expression |
EXP |
topiramate results in increased expression of ACADSB mRNA |
CTD |
PMID:16979414 |
|
NCBI chr 1:201,981,362...202,022,771
Ensembl chr 1:201,981,357...202,021,008
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G |
Acsl4 |
acyl-CoA synthetase long-chain family member 4 |
decreases expression |
EXP |
topiramate results in decreased expression of ACSL4 mRNA |
CTD |
PMID:16979414 |
|
NCBI chr X:113,596,247...113,660,024
Ensembl chr X:113,596,239...113,659,944
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G |
Adipoq |
adiponectin, C1Q and collagen domain containing |
increases expression increases secretion |
ISO |
topiramate results in increased expression of ADIPOQ mRNA topiramate results in increased secretion of ADIPOQ protein |
CTD |
PMID:12927809 |
|
NCBI chr11:81,330,845...81,344,488
Ensembl chr11:81,330,293...81,344,488
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G |
Adra2a |
adrenoceptor alpha 2A |
increases expression |
ISO |
topiramate results in increased expression of ADRA2A mRNA |
CTD |
PMID:22489711 |
|
NCBI chr 1:274,766,283...274,769,083
Ensembl chr 1:274,766,283...274,769,081
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G |
Agxt |
alanine--glyoxylate and serine--pyruvate aminotransferase |
increases expression |
EXP |
topiramate results in increased expression of AGXT mRNA |
CTD |
PMID:16979414 |
|
NCBI chr 9:100,281,339...100,291,292
Ensembl chr 9:100,281,339...100,291,291
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G |
Akt1 |
AKT serine/threonine kinase 1 |
multiple interactions |
EXP |
topiramate inhibits the reaction [3-nitropropionic acid results in decreased phosphorylation of AKT1 protein] |
CTD |
PMID:29753867 |
|
NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
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|
G |
Ass1 |
argininosuccinate synthase 1 |
decreases expression |
EXP |
topiramate results in decreased expression of ASS1 mRNA |
CTD |
PMID:16979414 |
|
NCBI chr 3:10,327,411...10,375,847
Ensembl chr 3:10,327,414...10,375,826
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G |
Avpr1a |
arginine vasopressin receptor 1A |
decreases expression |
EXP |
topiramate results in decreased expression of AVPR1A mRNA |
CTD |
PMID:16979414 |
|
NCBI chr 7:67,341,366...67,345,290
Ensembl chr 7:67,341,080...67,345,308
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|
G |
Bdnf |
brain-derived neurotrophic factor |
multiple interactions |
EXP |
topiramate inhibits the reaction [3-nitropropionic acid results in decreased expression of BDNF protein] |
CTD |
PMID:29753867 |
|
NCBI chr 3:100,768,637...100,819,216
Ensembl chr 3:100,768,637...100,819,210
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|
G |
Ca12 |
carbonic anhydrase 12 |
decreases activity |
ISO |
topiramate results in decreased activity of CA12 protein |
CTD |
PMID:21314129 |
|
NCBI chr 8:72,405,770...72,461,425
Ensembl chr 8:72,405,748...72,460,240
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|
G |
Ca3 |
carbonic anhydrase 3 |
multiple interactions |
ISO |
topiramate binds to and results in decreased activity of CA3 protein |
CTD |
PMID:17826101 |
|
NCBI chr 2:88,126,519...88,136,063
Ensembl chr 2:88,126,667...88,135,410
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G |
Calca |
calcitonin-related polypeptide alpha |
multiple interactions |
EXP |
Topiramate inhibits the reaction [Potassium Chloride results in increased secretion of CALCA protein]; Topiramate inhibits the reaction [Protons results in increased secretion of CALCA protein]; Topiramate inhibits the reaction [S-nitro-N-acetylpenicillamine results in increased secretion of CALCA protein] |
CTD |
PMID:16942474 |
|
NCBI chr 1:184,184,018...184,188,922
Ensembl chr 1:184,184,020...184,188,911
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|
G |
Capn6 |
calpain 6 |
increases expression |
EXP |
topiramate results in increased expression of CAPN6 mRNA |
CTD |
PMID:16979414 |
|
NCBI chr X:115,049,113...115,073,824
Ensembl chr X:115,049,154...115,073,890
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G |
Car1 |
carbonic anhydrase 1 |
multiple interactions |
ISO |
topiramate binds to and results in decreased activity of CA1 protein |
CTD |
PMID:17826101 |
|
NCBI chr 2:88,185,204...88,227,486
Ensembl chr 2:88,217,188...88,227,479
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|
G |
Car2 |
carbonic anhydrase 2 |
multiple interactions decreases activity |
ISO |
topiramate binds to and results in decreased activity of CA2 protein topiramate results in decreased activity of CA2 protein |
CTD |
PMID:17826101 PMID:21314129 |
|
NCBI chr 2:88,097,740...88,112,868
Ensembl chr 2:88,097,720...88,113,029
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|
G |
Casp3 |
caspase 3 |
affects expression multiple interactions |
EXP |
topiramate affects the expression of CASP3 mRNA; topiramate affects the expression of CASP3 protein topiramate inhibits the reaction [3-nitropropionic acid results in increased activity of CASP3 protein] |
CTD |
PMID:19148780 PMID:29753867 |
|
NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
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G |
Cebpa |
CCAAT/enhancer binding protein alpha |
decreases expression |
EXP |
topiramate results in decreased expression of CEBPA mRNA |
CTD |
PMID:16979414 |
|
NCBI chr 1:91,363,492...91,366,164
Ensembl chr 1:91,363,492...91,366,164
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G |
Chka |
choline kinase alpha |
decreases expression |
EXP |
topiramate results in decreased expression of CHKA mRNA |
CTD |
PMID:16979414 |
|
NCBI chr 1:219,076,618...219,126,221
Ensembl chr 1:219,077,771...219,126,220
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G |
Chrna7 |
cholinergic receptor nicotinic alpha 7 subunit |
decreases expression |
EXP |
topiramate results in decreased expression of CHRNA7 mRNA |
CTD |
PMID:16979414 |
|
NCBI chr 1:123,897,341...124,039,263
Ensembl chr 1:123,899,657...124,039,196
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G |
Cited2 |
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 |
decreases expression |
EXP |
topiramate results in decreased expression of CITED2 mRNA |
CTD |
PMID:16979414 |
|
NCBI chr 1:12,823,363...12,825,806
Ensembl chr 1:12,823,363...12,825,786
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G |
Cnr1 |
cannabinoid receptor 1 |
affects expression |
ISO |
topiramate affects the expression of CNR1 mRNA |
CTD |
PMID:22017514 |
|
NCBI chr 5:49,307,584...49,333,064
Ensembl chr 5:49,311,030...49,333,056
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|
G |
Creb1 |
cAMP responsive element binding protein 1 |
multiple interactions |
EXP |
topiramate inhibits the reaction [3-nitropropionic acid results in decreased phosphorylation of CREB1 protein] |
CTD |
PMID:29753867 |
|
NCBI chr 9:71,229,753...71,298,994
Ensembl chr 9:71,230,108...71,293,435
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|
G |
Cyp17a1 |
cytochrome P450, family 17, subfamily a, polypeptide 1 |
decreases activity |
ISO |
topiramate results in decreased activity of CYP17A1 protein |
CTD |
PMID:15730543 |
|
NCBI chr 1:266,422,127...266,429,947
Ensembl chr 1:266,422,132...266,428,239
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|
G |
Cyp3a62 |
cytochrome P450, family 3, subfamily a, polypeptide 62 |
increases activity increases expression |
ISO |
Topiramate results in increased activity of CYP3A4 protein Topiramate results in increased expression of CYP3A4 mRNA; Topiramate results in increased expression of CYP3A4 protein |
CTD |
PMID:14636322 |
|
NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397
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|
G |
Drd2 |
dopamine receptor D2 |
increases expression |
ISO |
topiramate results in increased expression of DRD2 mRNA |
CTD |
PMID:22489711 |
|
NCBI chr 8:53,678,777...53,743,643
Ensembl chr 8:53,678,777...53,743,642
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G |
Dusp1 |
dual specificity phosphatase 1 |
increases expression |
EXP |
topiramate results in increased expression of DUSP1 mRNA |
CTD |
PMID:16979414 |
|
NCBI chr10:16,970,642...16,973,425
Ensembl chr10:16,970,626...16,973,418
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G |
Fabp3 |
fatty acid binding protein 3 |
decreases expression |
EXP |
topiramate results in decreased expression of FABP3 mRNA |
CTD |
PMID:16979414 |
|
NCBI chr 5:148,528,854...148,535,597
Ensembl chr 5:148,528,725...148,535,565
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|
G |
Gabra1 |
gamma-aminobutyric acid type A receptor subunit alpha 1 |
multiple interactions |
EXP |
topiramate inhibits the reaction [[gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein co-treated with GABRB2 protein co-treated with GABRG2 protein]] which results in increased transport of Chlorides] |
CTD |
PMID:11123204 |
|
NCBI chr10:27,310,718...27,371,802
Ensembl chr10:27,310,725...27,366,665
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|
G |
Gabra2 |
gamma-aminobutyric acid type A receptor subunit alpha 2 |
multiple interactions |
EXP |
topiramate inhibits the reaction [[gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein co-treated with GABRB2 protein co-treated with GABRG2 protein]] which results in increased transport of Chlorides] |
CTD |
PMID:11123204 |
|
NCBI chr14:39,662,411...39,801,082
Ensembl chr14:39,661,968...39,798,302
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|
G |
Gabra6 |
gamma-aminobutyric acid type A receptor subunit alpha6 |
multiple interactions |
EXP |
topiramate promotes the reaction [[gamma-Aminobutyric Acid results in increased activity of [GABRA6 protein co-treated with GABRB2 protein co-treated with GABRG2 protein]] which results in increased transport of Chlorides] |
CTD |
PMID:11123204 |
|
NCBI chr10:27,847,447...27,862,896
Ensembl chr10:27,847,439...27,862,868
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|
G |
Gabrb2 |
gamma-aminobutyric acid type A receptor subunit beta 2 |
multiple interactions |
EXP |
topiramate inhibits the reaction [[gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein co-treated with GABRB2 protein co-treated with GABRG2 protein]] which results in increased transport of Chlorides]; topiramate inhibits the reaction [[gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein co-treated with GABRB2 protein co-treated with GABRG2 protein]] which results in increased transport of Chlorides]; topiramate promotes the reaction [[gamma-Aminobutyric Acid results in increased activity of [GABRA6 protein co-treated with GABRB2 protein co-treated with GABRG2 protein]] which results in increased transport of Chlorides] |
CTD |
PMID:11123204 |
|
NCBI chr10:27,973,694...28,193,072
Ensembl chr10:27,973,681...28,187,565
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|
G |
Gabrg2 |
gamma-aminobutyric acid type A receptor subunit gamma 2 |
multiple interactions |
EXP |
topiramate inhibits the reaction [[gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein co-treated with GABRB2 protein co-treated with GABRG2 protein]] which results in increased transport of Chlorides]; topiramate inhibits the reaction [[gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein co-treated with GABRB2 protein co-treated with GABRG2 protein]] which results in increased transport of Chlorides]; topiramate promotes the reaction [[gamma-Aminobutyric Acid results in increased activity of [GABRA6 protein co-treated with GABRB2 protein co-treated with GABRG2 protein]] which results in increased transport of Chlorides] |
CTD |
PMID:11123204 |
|
NCBI chr10:27,090,913...27,179,786
Ensembl chr10:27,092,827...27,179,900
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G |
Glul |
glutamate-ammonia ligase |
decreases activity |
ISO |
topiramate results in decreased activity of GLUL protein |
CTD |
PMID:10323596 |
|
NCBI chr13:71,331,052...71,340,207
Ensembl chr13:71,331,052...71,340,229
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G |
Gnai2 |
G protein subunit alpha i2 |
decreases expression |
EXP |
topiramate results in decreased expression of GNAI2 mRNA |
CTD |
PMID:16979414 |
|
NCBI chr 8:116,370,730...116,391,337
Ensembl chr 8:116,370,744...116,391,307
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G |
Got2 |
glutamic-oxaloacetic transaminase 2 |
increases expression |
EXP |
topiramate results in increased expression of GOT2 mRNA |
CTD |
PMID:16979414 |
|
NCBI chr19:9,587,637...9,613,323
Ensembl chr19:9,587,653...9,613,340
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G |
Gpam |
glycerol-3-phosphate acyltransferase, mitochondrial |
decreases expression |
EXP |
topiramate results in decreased expression of GPAM mRNA |
CTD |
PMID:16979414 |
|
NCBI chr 1:275,843,823...275,906,880
Ensembl chr 1:275,846,819...275,906,686
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G |
Gpd2 |
glycerol-3-phosphate dehydrogenase 2 |
increases expression |
EXP |
topiramate results in increased expression of GPD2 mRNA |
CTD |
PMID:16979414 |
|
NCBI chr 3:43,223,892...43,359,069
Ensembl chr 3:43,255,567...43,359,074
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G |
Gria2 |
glutamate ionotropic receptor AMPA type subunit 2 |
multiple interactions |
EXP |
topiramate inhibits the reaction [3-nitropropionic acid results in decreased expression of GRIA2 mRNA] |
CTD |
PMID:29753867 |
|
NCBI chr 2:179,584,302...179,704,629
Ensembl chr 2:179,584,308...179,704,629
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G |
Grik1 |
glutamate ionotropic receptor kainate type subunit 1 |
affects response to substance |
ISO |
GRIK1 gene SNP affects the susceptibility to topiramate |
CTD |
PMID:19331489 |
|
NCBI chr11:27,811,954...28,213,940
Ensembl chr11:27,811,957...27,971,359
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G |
Gsk3b |
glycogen synthase kinase 3 beta |
multiple interactions |
EXP |
topiramate inhibits the reaction [3-nitropropionic acid results in decreased phosphorylation of GSK3B protein] |
CTD |
PMID:29753867 |
|
NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268
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G |
Gtf2a2 |
general transcription factor 2A subunit 2 |
increases expression |
EXP |
topiramate results in increased expression of GTF2A2 mRNA |
CTD |
PMID:16979414 |
|
NCBI chr 8:76,422,341...76,435,587
Ensembl chr 8:76,422,359...76,435,473
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G |
Gyg1 |
glycogenin 1 |
decreases expression |
EXP |
topiramate results in decreased expression of GYG1 mRNA |
CTD |
PMID:16979414 |
|
NCBI chr 2:104,916,734...104,958,219
Ensembl chr 2:104,916,738...104,958,034
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G |
Hmgcs1 |
3-hydroxy-3-methylglutaryl-CoA synthase 1 |
increases expression |
EXP |
topiramate results in increased expression of HMGCS1 mRNA |
CTD |
PMID:16979414 |
|
NCBI chr 2:52,427,351...52,445,082
Ensembl chr 2:52,431,601...52,445,055
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G |
Hsd3b2 |
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 |
decreases activity |
ISO |
topiramate results in decreased activity of HSD3B2 protein |
CTD |
PMID:15730543 |
|
NCBI chr 2:200,712,895...200,722,429
Ensembl chr 2:202,341,422...202,350,929
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G |
Idi1 |
isopentenyl-diphosphate delta isomerase 1 |
increases expression |
EXP |
topiramate results in increased expression of IDI1 mRNA |
CTD |
PMID:16979414 |
|
NCBI chr17:57,976,266...57,984,036
Ensembl chr17:57,976,268...57,984,036
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G |
Ifi30 |
IFI30, lysosomal thiol reductase |
multiple interactions |
EXP |
[topiramate co-treated with Trinitrobenzenesulfonic Acid] results in decreased expression of IFI30 mRNA |
CTD |
PMID:21849664 |
|
NCBI chr16:20,426,566...20,430,772
Ensembl chr16:20,426,566...20,430,752
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G |
Igf1 |
insulin-like growth factor 1 |
decreases expression |
EXP |
topiramate results in decreased expression of IGF1 mRNA |
CTD |
PMID:16979414 |
|
NCBI chr 7:28,412,123...28,491,815
Ensembl chr 7:28,412,198...28,486,609
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G |
Itpr1 |
inositol 1,4,5-trisphosphate receptor, type 1 |
increases expression |
EXP |
topiramate results in increased expression of ITPR1 mRNA |
CTD |
PMID:16979414 |
|
NCBI chr 4:140,247,297...140,580,749
Ensembl chr 4:140,247,313...140,580,748
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G |
Kcnh2 |
potassium voltage-gated channel subfamily H member 2 |
decreases activity |
ISO |
topiramate results in decreased activity of KCNH2 protein |
CTD |
PMID:15716081 |
|
NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253
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G |
Me1 |
malic enzyme 1 |
decreases expression |
EXP |
topiramate results in decreased expression of ME1 mRNA |
CTD |
PMID:16979414 |
|
NCBI chr 8:94,256,830...94,368,834
Ensembl chr 8:94,256,839...94,368,834
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G |
Mvd |
mevalonate diphosphate decarboxylase |
increases expression |
EXP |
topiramate results in increased expression of MVD mRNA |
CTD |
PMID:16979414 |
|
NCBI chr19:55,258,910...55,268,933
Ensembl chr19:55,258,905...55,268,951
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G |
Nos2 |
nitric oxide synthase 2 |
increases expression |
EXP |
topiramate results in increased expression of NOS2 protein |
CTD |
PMID:14511393 |
|
NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
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G |
Npy |
neuropeptide Y |
increases expression |
EXP |
topiramate results in increased expression of NPY protein |
CTD |
PMID:17572454 |
|
NCBI chr 4:79,557,856...79,565,059
Ensembl chr 4:79,557,854...79,565,097 Ensembl chr 4:79,557,854...79,565,097
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G |
Nr1i2 |
nuclear receptor subfamily 1, group I, member 2 |
increases activity |
ISO |
topiramate results in increased activity of NR1I2 protein |
CTD |
PMID:14636322 |
|
NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
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G |
Nr2f2 |
nuclear receptor subfamily 2, group F, member 2 |
decreases expression |
EXP |
topiramate results in decreased expression of NR2F2 mRNA |
CTD |
PMID:16979414 |
|
NCBI chr 1:131,447,671...131,465,749
Ensembl chr 1:131,448,447...131,460,473
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G |
Nr4a2 |
nuclear receptor subfamily 4, group A, member 2 |
decreases expression |
EXP |
topiramate results in decreased expression of NR4A2 mRNA |
CTD |
PMID:16979414 |
|
NCBI chr 3:43,111,258...43,128,391
Ensembl chr 3:43,111,240...43,119,159
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G |
Pde4b |
phosphodiesterase 4B |
decreases expression |
EXP |
topiramate results in decreased expression of PDE4B mRNA |
CTD |
PMID:16979414 |
|
NCBI chr 5:121,759,236...122,136,814
Ensembl chr 5:121,952,977...122,136,814
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G |
Pdk4 |
pyruvate dehydrogenase kinase 4 |
decreases expression |
EXP |
topiramate results in decreased expression of PDK4 mRNA |
CTD |
PMID:16979414 |
|
NCBI chr 4:30,546,772...30,556,774
Ensembl chr 4:30,546,664...30,556,814
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G |
Pick1 |
protein interacting with PRKCA 1 |
multiple interactions |
EXP |
topiramate inhibits the reaction [3-nitropropionic acid results in increased expression of PICK1 protein] |
CTD |
PMID:29753867 |
|
NCBI chr 7:120,465,472...120,484,824
Ensembl chr 7:120,465,130...120,484,840
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G |
Plcd4 |
phospholipase C, delta 4 |
decreases expression |
EXP |
topiramate results in decreased expression of PLCD4 mRNA |
CTD |
PMID:16979414 |
|
NCBI chr 9:81,816,395...81,844,364
Ensembl chr 9:81,816,872...81,844,364
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G |
Pld1 |
phospholipase D1 |
increases expression |
EXP |
topiramate results in increased expression of PLD1 mRNA |
CTD |
PMID:16979414 |
|
NCBI chr 2:113,651,967...113,849,403
Ensembl chr 2:113,652,348...113,849,403
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G |
Ppp5c |
protein phosphatase 5, catalytic subunit |
increases expression |
EXP |
topiramate results in increased expression of PPP5C mRNA |
CTD |
PMID:16979414 |
|
NCBI chr 1:78,944,054...78,968,361
Ensembl chr 1:78,944,040...78,968,329
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G |
Prkag1 |
protein kinase AMP-activated non-catalytic subunit gamma 1 |
decreases expression |
EXP |
topiramate results in decreased expression of PRKAG1 mRNA |
CTD |
PMID:16979414 |
|
NCBI chr 7:140,489,499...140,506,925
Ensembl chr 7:140,489,492...140,546,908
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G |
Prkar2b |
protein kinase cAMP-dependent type II regulatory subunit beta |
decreases expression |
EXP |
topiramate results in decreased expression of PRKAR2B mRNA |
CTD |
PMID:16979414 |
|
NCBI chr 6:51,265,509...51,356,383
Ensembl chr 6:51,265,515...51,356,383
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G |
RT1-DMb |
RT1 class II, locus DMb |
affects expression |
ISO |
topiramate affects the expression of HLA-DMB mRNA |
CTD |
PMID:25811541 |
|
NCBI chr20:3,945,383...3,952,838
Ensembl chr20:5,227,045...5,234,290 Ensembl chr20:5,227,045...5,234,290
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G |
Scd |
stearoyl-CoA desaturase |
decreases expression |
EXP |
topiramate results in decreased expression of SCD1 mRNA |
CTD |
PMID:16979414 |
|
NCBI chr 1:264,159,966...264,173,061
Ensembl chr 1:264,160,129...264,172,729
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G |
Slc16a1 |
solute carrier family 16 member 1 |
increases expression |
EXP |
topiramate results in increased expression of SLC16A1 mRNA |
CTD |
PMID:16979414 |
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NCBI chr 2:207,108,552...207,129,352
Ensembl chr 2:207,108,552...207,128,554
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G |
Slc37a4 |
solute carrier family 37 member 4 |
decreases expression |
EXP |
topiramate results in decreased expression of SLC37A4 mRNA |
CTD |
PMID:16979414 |
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NCBI chr 8:48,716,914...48,723,024
Ensembl chr 8:48,716,939...48,723,024
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G |
Slc47a1 |
solute carrier family 47 member 1 |
multiple interactions |
ISO |
topiramate affects the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] |
CTD |
PMID:22419765 |
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NCBI chr10:47,631,425...47,685,379
Ensembl chr10:47,632,192...47,666,921
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G |
Slc6a6 |
solute carrier family 6 member 6 |
decreases expression |
EXP |
topiramate results in decreased expression of SLC6A6 mRNA |
CTD |
PMID:16979414 |
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NCBI chr 4:123,638,619...123,713,469
Ensembl chr 4:123,642,210...123,713,464
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G |
Slc7a1 |
solute carrier family 7 member 1 |
decreases expression |
EXP |
topiramate results in decreased expression of SLC7A1 mRNA |
CTD |
PMID:16979414 |
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NCBI chr12:8,032,775...8,108,972
Ensembl chr12:8,032,809...8,108,972
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G |
Sqle |
squalene epoxidase |
decreases expression |
EXP |
topiramate results in decreased expression of SQLE mRNA |
CTD |
PMID:16979414 |
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NCBI chr 7:99,609,929...99,624,803
Ensembl chr 7:99,609,191...99,624,732
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G |
Srebf1 |
sterol regulatory element binding transcription factor 1 |
increases expression |
EXP |
topiramate results in increased expression of SREBF1 mRNA |
CTD |
PMID:16979414 |
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NCBI chr10:46,570,996...46,593,021
Ensembl chr10:46,570,996...46,593,009
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G |
Th |
tyrosine hydroxylase |
affects expression increases expression |
ISO |
topiramate affects the expression of TH mRNA topiramate results in increased expression of TH mRNA |
CTD |
PMID:22017514 PMID:22489711 |
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NCBI chr 1:216,073,034...216,080,287
Ensembl chr 1:216,073,031...216,080,287
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G |
Trpv1 |
transient receptor potential cation channel, subfamily V, member 1 |
multiple interactions |
EXP |
topiramate inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of TRPV1 mRNA] |
CTD |
PMID:21849664 |
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NCBI chr10:59,799,123...59,824,208
Ensembl chr10:59,799,123...59,824,679
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G |
Ucp3 |
uncoupling protein 3 |
decreases expression |
EXP |
topiramate results in decreased expression of UCP3 mRNA |
CTD |
PMID:16979414 |
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NCBI chr 1:165,482,912...165,495,895
Ensembl chr 1:165,482,155...165,496,206
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G |
Ugt2b7 |
UDP glucuronosyltransferase family 2 member B7 |
affects response to substance |
ISO |
UGT2B7 gene SNP affects the susceptibility to topiramate |
CTD |
PMID:18686368 |
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NCBI chr14:22,597,103...22,619,968
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