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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:ketohexose
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Accession:CHEBI:24973 term browser browse the term
Definition:Any hexose containing a single ketone group.
Synonyms:related_synonym: ketohexoses

show annotations for term's descendants           Sort by:
 
3-deoxyglucosone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1b8 aldo-keto reductase family 1, member B8 multiple interactions EXP [AKR1B8 protein co-treated with NADP] affects the reduction of 3-deoxyglucosone CTD PMID:18845131 NCBI chr 4:61,772,064...61,784,637
Ensembl chr 4:61,771,970...61,828,657 		JBrowse link
beta-D-fructofuranose 1,6-bisphosphate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gapdh glyceraldehyde-3-phosphate dehydrogenase multiple interactions EXP [GAPDH protein co-treated with fructose-1,6-diphosphate co-treated with NAD] results in increased chemical synthesis of sodium arsenite; [GAPDH protein co-treated with fructose-1,6-diphosphate co-treated with NAD] results in increased reduction of sodium arsenate analog; heptelidic acid inhibits the reaction [[GAPDH protein co-treated with fructose-1,6-diphosphate co-treated with NAD] results in increased reduction of sodium arsenate analog] CTD PMID:15788719 NCBI chr 4:157,676,336...157,680,322
Ensembl chr 4:157,676,595...157,679,962 		JBrowse link
G Idh2 isocitrate dehydrogenase (NADP(+)) 2 increases abundance
multiple interactions		 ISO IDH2 protein mutant form results in increased abundance of fructose-1,6-diphosphate
Triazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of fructose-1,6-diphosphate]		 CTD PMID:27469509 NCBI chr 1:141,874,354...141,893,674
Ensembl chr 1:141,866,283...141,893,705 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO fructose-1,6-diphosphate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein] CTD PMID:22227475 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO fructose-1,6-diphosphate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein] CTD PMID:22227475 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
decreases degradation		 ISO fructose-1,6-diphosphate inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; fructose-1,6-diphosphate inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]
fructose-1,6-diphosphate results in decreased degradation of NOS2 mRNA		 CTD PMID:22227475 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190 		JBrowse link
beta-D-fructofuranose 2,6-bisphosphate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pfkm phosphofructokinase, muscle multiple interactions ISO fructose 2,6-diphosphate inhibits the reaction [resveratrol results in decreased activity of PFKM protein] CTD PMID:23454376 NCBI chr 7:139,702,066...139,722,132
Ensembl chr 7:139,685,573...139,722,132 		JBrowse link
D-fructofuranose 1,6-bisphosphate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gapdh glyceraldehyde-3-phosphate dehydrogenase multiple interactions EXP [GAPDH protein co-treated with fructose-1,6-diphosphate co-treated with NAD] results in increased chemical synthesis of sodium arsenite; [GAPDH protein co-treated with fructose-1,6-diphosphate co-treated with NAD] results in increased reduction of sodium arsenate analog; heptelidic acid inhibits the reaction [[GAPDH protein co-treated with fructose-1,6-diphosphate co-treated with NAD] results in increased reduction of sodium arsenate analog] CTD PMID:15788719 NCBI chr 4:157,676,336...157,680,322
Ensembl chr 4:157,676,595...157,679,962 		JBrowse link
G Idh2 isocitrate dehydrogenase (NADP(+)) 2 increases abundance
multiple interactions		 ISO IDH2 protein mutant form results in increased abundance of fructose-1,6-diphosphate
Triazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of fructose-1,6-diphosphate]		 CTD PMID:27469509 NCBI chr 1:141,874,354...141,893,674
Ensembl chr 1:141,866,283...141,893,705 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO fructose-1,6-diphosphate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein] CTD PMID:22227475 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO fructose-1,6-diphosphate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein] CTD PMID:22227475 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
decreases degradation		 ISO fructose-1,6-diphosphate inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; fructose-1,6-diphosphate inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]
fructose-1,6-diphosphate results in decreased degradation of NOS2 mRNA		 CTD PMID:22227475 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190 		JBrowse link
fructose term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A1bg alpha-1-B glycoprotein multiple interactions EXP [Fructose co-treated with bisphenol A] results in decreased expression of A1BG protein CTD PMID:26930160 NCBI chr 7:102,294,805...102,298,522
Ensembl chr 7:102,294,797...102,298,522 		JBrowse link
G Abca1 ATP binding cassette subfamily A member 1 multiple interactions
increases expression		 EXP Tea inhibits the reaction [Fructose results in increased expression of ABCA1 mRNA] CTD PMID:19193814 NCBI chr 5:69,857,717...69,983,042
Ensembl chr 5:69,857,771...69,983,015 		JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 multiple interactions
decreases expression		 EXP Ascorbic Acid inhibits the reaction [Fructose results in decreased expression of ABCC2 mRNA]; Ascorbic Acid inhibits the reaction [Fructose results in decreased expression of ABCC2 protein]; geraniol inhibits the reaction [Fructose results in decreased expression of ABCC2 mRNA]; geraniol inhibits the reaction [Fructose results in decreased expression of ABCC2 protein]
Fructose results in decreased expression of ABCC2 mRNA; Fructose results in decreased expression of ABCC2 protein		 CTD PMID:31005848 NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252 		JBrowse link
G Acaca acetyl-CoA carboxylase alpha multiple interactions
decreases phosphorylation
increases expression		 ISO
EXP		 FGF21 gene mutant form inhibits the reaction [Fructose results in increased expression of ACACA mRNA]; Phenylbutyrates inhibits the reaction [Fructose results in increased expression of ACACA mRNA]; SCD1 gene mutant form inhibits the reaction [Fructose results in increased expression of ACACA mRNA]; Triolein inhibits the reaction [SCD1 gene mutant form inhibits the reaction [Fructose results in increased expression of ACACA mRNA]]; Triolein promotes the reaction [Fructose results in increased expression of ACACA mRNA]
Fructose results in decreased phosphorylation of ACACA protein
[6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in decreased activity of SIRT1 protein] inhibits the reaction [Fructose results in increased expression of ACACA mRNA]; [Niacinamide results in decreased activity of SIRT1 protein] inhibits the reaction [Fructose results in increased expression of ACACA mRNA]; Fructose inhibits the reaction [Streptozocin results in decreased activity of ACACA protein]; Fructose inhibits the reaction [Streptozocin results in decreased expression of ACACA mRNA]; Rotenone inhibits the reaction [Fructose results in increased expression of ACACA mRNA]		 CTD PMID:1973097 PMID:15066988 PMID:21212096 PMID:22698815 PMID:28123933 PMID:31672515 NCBI chr10:71,519,392...71,719,910
Ensembl chr10:71,536,533...71,719,910 		JBrowse link
G Acacb acetyl-CoA carboxylase beta decreases expression
increases expression
multiple interactions		 ISO
EXP		 Fructose results in decreased expression of ACACB mRNA
Fructose results in increased expression of ACACB mRNA
FGF21 gene mutant form inhibits the reaction [Fructose results in increased expression of ACACB mRNA]		 CTD PMID:18063403 PMID:19053045 PMID:28123933 NCBI chr12:48,127,149...48,238,969
Ensembl chr12:48,127,149...48,238,887 		JBrowse link
G Acadl acyl-CoA dehydrogenase, long chain multiple interactions EXP [Fructose co-treated with Copper deficiency] results in decreased expression of ACADL mRNA CTD PMID:25813056 NCBI chr 9:73,833,368...73,871,857
Ensembl chr 9:73,833,388...73,871,888 		JBrowse link
G Acadm acyl-CoA dehydrogenase medium chain multiple interactions EXP [Fructose co-treated with Copper deficiency] results in decreased expression of ACADM mRNA CTD PMID:25813056 NCBI chr 2:260,124,418...260,148,589
Ensembl chr 2:260,124,418...260,148,589 		JBrowse link
G Acads acyl-CoA dehydrogenase short chain multiple interactions EXP [Fructose co-treated with bisphenol A] results in decreased expression of ACADS protein CTD PMID:26930160 NCBI chr12:47,254,503...47,263,747
Ensembl chr12:47,254,484...47,263,747 		JBrowse link
G Acadvl acyl-CoA dehydrogenase, very long chain multiple interactions EXP [Fructose co-treated with bisphenol A] results in increased expression of ACADVL protein; [Fructose co-treated with Copper deficiency] results in decreased expression of ACADVL mRNA CTD PMID:25813056 PMID:26930160 NCBI chr10:56,619,321...56,624,468
Ensembl chr10:56,619,303...56,624,526 		JBrowse link
G Ace angiotensin I converting enzyme increases expression
multiple interactions		 EXP Fructose results in increased expression of ACE mRNA
[bisphenol A co-treated with Fructose] results in increased expression of ACE mRNA; APLN protein modified form inhibits the reaction [Fructose results in increased expression of ACE mRNA]		 CTD PMID:17587757 PMID:27622962 PMID:30710622 NCBI chr10:94,170,766...94,213,831
Ensembl chr10:94,170,766...94,187,822 		JBrowse link
G Acly ATP citrate lyase increases expression EXP Fructose results in increased expression of ACLY mRNA CTD PMID:1396700 NCBI chr10:88,392,248...88,442,845
Ensembl chr10:88,392,248...88,442,845 		JBrowse link
G Acox1 acyl-CoA oxidase 1 multiple interactions
decreases expression		 EXP Atorvastatin inhibits the reaction [Fructose results in decreased expression of ACOX1 mRNA] CTD PMID:21122807 NCBI chr10:104,724,534...104,748,003
Ensembl chr10:104,722,958...104,748,050 		JBrowse link
G Acsf2 acyl-CoA synthetase family member 2 multiple interactions EXP [Fructose co-treated with bisphenol A] results in increased expression of ACSF2 protein CTD PMID:26930160 NCBI chr10:82,284,719...82,326,771
Ensembl chr10:82,284,720...82,326,771 		JBrowse link
G Acta2 actin alpha 2, smooth muscle increases expression
multiple interactions		 EXP Fructose results in increased expression of ACTA2 protein
2-(3-(4-ethoxybenzyl)-4-chlorophenyl)-6-hydroxymethyltetrahydro-2H-pyran-3,4,5-triol inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of ACTA2 protein]; [Streptozocin co-treated with Fructose] results in increased expression of ACTA2 protein; Genistein inhibits the reaction [Fructose results in increased expression of ACTA2 protein]; Metformin promotes the reaction [2-(3-(4-ethoxybenzyl)-4-chlorophenyl)-6-hydroxymethyltetrahydro-2H-pyran-3,4,5-triol inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of ACTA2 protein]]		 CTD PMID:21704028 PMID:30551545 NCBI chr 1:252,537,614...252,550,394
Ensembl chr 1:252,537,615...252,550,394 		JBrowse link
G Ada adenosine deaminase multiple interactions
increases activity		 EXP Glutamine inhibits the reaction [Fructose results in increased activity of ADA protein] CTD PMID:31233715 NCBI chr 3:160,115,840...160,139,947
Ensembl chr 3:160,115,842...160,139,947 		JBrowse link
G Adgre1 adhesion G protein-coupled receptor E1 multiple interactions
increases expression		 EXP
ISO		 [gadolinium chloride co-treated with Fructose co-treated with Copper deficiency] results in decreased expression of ADGRE1 mRNA
Fructose results in increased expression of ADGRE1 protein
Ethanol promotes the reaction [Fructose results in increased expression of ADGRE1 protein]; Fructose promotes the reaction [Ethanol results in increased expression of ADGRE1 mRNA]; Fructose promotes the reaction [Ethanol results in increased expression of ADGRE1 protein]		 CTD PMID:25813056 PMID:26858005 NCBI chr 9:9,431,888...9,585,883
Ensembl chr 9:9,431,860...9,585,865 		JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing multiple interactions
decreases secretion
increases secretion
decreases expression
increases expression		 EXP
ISO		 [Particulate Matter co-treated with Ozone] promotes the reaction [Fructose results in decreased expression of ADIPOQ mRNA]; Curcumin inhibits the reaction [Fructose results in decreased expression of ADIPOQ protein]; geraniol inhibits the reaction [Fructose results in decreased secretion of ADIPOQ protein]; Metformin inhibits the reaction [Fructose results in decreased expression of ADIPOQ protein]; Ozone promotes the reaction [Fructose results in decreased expression of ADIPOQ mRNA]; Particulate Matter promotes the reaction [Fructose results in decreased expression of ADIPOQ mRNA]; Pioglitazone inhibits the reaction [Fructose results in decreased secretion of ADIPOQ protein]; Resveratrol inhibits the reaction [Fructose results in decreased expression of ADIPOQ mRNA]; Resveratrol inhibits the reaction [Fructose results in decreased expression of ADIPOQ protein]; sapropterin inhibits the reaction [Fructose results in decreased expression of ADIPOQ mRNA]; sapropterin inhibits the reaction [Fructose results in decreased expression of ADIPOQ protein]
Fructose results in increased secretion of ADIPOQ protein
Fructose results in decreased expression of ADIPOQ mRNA; Fructose results in decreased expression of ADIPOQ protein
Fructose results in increased expression of ADIPOQ mRNA; Fructose results in increased expression of ADIPOQ protein		 CTD PMID:17098227 PMID:19165636 PMID:21122807 PMID:23016136 PMID:23968387 PMID:25108154 PMID:25679220 PMID:26713546 PMID:26973390 PMID:28257781 NCBI chr11:81,330,845...81,344,488
Ensembl chr11:81,330,293...81,344,488 		JBrowse link
G Adipor2 adiponectin receptor 2 decreases expression ISO Fructose results in decreased expression of ADIPOR2 protein CTD PMID:28257781 NCBI chr 4:151,412,135...151,480,108
Ensembl chr 4:151,414,684...151,428,894 		JBrowse link
G Ager advanced glycosylation end product-specific receptor increases expression
multiple interactions		 EXP Fructose results in increased expression of AGER protein
Genistein inhibits the reaction [Fructose results in increased expression of AGER protein]; geraniol inhibits the reaction [Fructose results in increased expression of AGER protein]; Pioglitazone inhibits the reaction [Fructose results in increased expression of AGER protein]		 CTD PMID:21704028 PMID:25679220 NCBI chr20:4,363,152...4,366,079
Ensembl chr20:4,363,152...4,366,079 		JBrowse link
G Agt angiotensinogen increases expression
multiple interactions		 EXP
ISO		 Fructose results in increased expression of AGT mRNA; Fructose results in increased expression of AGT protein; Fructose results in increased expression of AGT protein modified form
APLN protein modified form inhibits the reaction [Fructose results in increased expression of AGT mRNA]; APLN protein modified form inhibits the reaction [Fructose results in increased expression of AGT protein modified form]; APLN protein modified form inhibits the reaction [Fructose results in increased expression of AGT protein]		 CTD PMID:11741341 PMID:16843071 PMID:17587757 PMID:18360027 PMID:30710622 NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433 		JBrowse link
G Agtr1a angiotensin II receptor, type 1a multiple interactions
increases expression		 EXP
ISO		 APLN protein modified form inhibits the reaction [Fructose results in increased expression of AGTR1A mRNA]; INS protein inhibits the reaction [Fructose results in increased expression of AGTR1A mRNA]
Fructose results in increased expression of AGTR1 mRNA		 CTD PMID:16843071 PMID:17587757 PMID:18360027 PMID:30710622 PMID:31655124 NCBI chr17:35,907,102...35,958,136
Ensembl chr17:35,907,108...35,958,077 		JBrowse link
G Agtr1b angiotensin II receptor, type 1b increases expression
multiple interactions		 EXP Fructose results in increased expression of AGTR1B mRNA
KLK1 protein inhibits the reaction [Fructose results in increased expression of AGTR1B mRNA]		 CTD PMID:14568997 NCBI chr 2:105,149,020...105,224,335
Ensembl chr 2:105,149,020...105,224,295 		JBrowse link
G Agtr2 angiotensin II receptor, type 2 multiple interactions
increases expression		 EXP APLN protein modified form inhibits the reaction [Fructose results in increased expression of AGTR2 mRNA] CTD PMID:30710622 NCBI chr  X:119,389,480...119,393,845
Ensembl chr  X:119,390,013...119,393,842 		JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions ISO [Dietary Fats co-treated with Fructose] results in increased expression of AHR mRNA; AHR protein results in increased susceptibility to [Dietary Fats co-treated with Fructose]; NR0B2 protein inhibits the reaction [AHR protein results in increased susceptibility to [Dietary Fats co-treated with Fructose]]; PEMT protein promotes the reaction [AHR protein results in increased susceptibility to [Dietary Fats co-treated with Fructose]] CTD PMID:29416063 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464 		JBrowse link
G Akr1b1 aldo-keto reductase family 1 member B multiple interactions EXP [Fructose co-treated with bisphenol A] results in increased expression of AKR1B1 protein CTD PMID:26930160 NCBI chr 4:61,706,866...61,720,959
Ensembl chr 4:61,706,864...61,720,956 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation
increases phosphorylation
multiple interactions		 EXP Fructose results in decreased phosphorylation of AKT1 protein
Fructose results in increased phosphorylation of AKT1 protein
[2-(3-(4-ethoxybenzyl)-4-chlorophenyl)-6-hydroxymethyltetrahydro-2H-pyran-3,4,5-triol co-treated with Atorvastatin] inhibits the reaction [[Fructose co-treated with Dietary Fats] results in decreased expression of AKT1 protein]; [Fructose co-treated with Dietary Fats] results in decreased expression of and results in decreased phosphorylation of AKT1 protein; [Fructose co-treated with Oleanolic Acid] results in increased expression of AKT1 mRNA; NOS3 protein inhibits the reaction [Fructose results in decreased phosphorylation of AKT1 protein]; Quercetin inhibits the reaction [Fructose results in decreased phosphorylation of AKT1 protein]; Quercetin inhibits the reaction [Fructose results in increased phosphorylation of AKT1 protein]; Rutin inhibits the reaction [Fructose results in decreased phosphorylation of AKT1 protein]		 CTD PMID:18497449 PMID:19008412 PMID:22426011 PMID:23533474 PMID:24704288 PMID:32259528 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258 		JBrowse link
G Aldob aldolase, fructose-bisphosphate B increases expression
multiple interactions		 ISO
EXP		 Fructose results in increased expression of ALDOB mRNA
FGF21 gene mutant form inhibits the reaction [Fructose results in increased expression of ALDOB mRNA]		 CTD PMID:15066988 PMID:18346472 PMID:28123933 NCBI chr 5:64,805,772...64,818,813
Ensembl chr 5:64,805,773...64,818,824 		JBrowse link
G Alox5 arachidonate 5-lipoxygenase increases expression ISO Fructose results in increased expression of ALOX5 mRNA CTD PMID:31655124 NCBI chr 4:148,398,004...148,446,308
Ensembl chr 4:148,398,892...148,446,303 		JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 multiple interactions ISO [Fructose co-treated with Dietary Fats] results in increased expression of APAF1 mRNA; troxerutin inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of APAF1 mRNA] CTD PMID:28916335 NCBI chr 7:31,699,309...31,784,192
Ensembl chr 7:31,699,885...31,784,192 		JBrowse link
G Apln apelin multiple interactions EXP APLN protein modified form inhibits the reaction [Fructose results in decreased activity of CAT protein]; APLN protein modified form inhibits the reaction [Fructose results in decreased expression of APLNR mRNA]; APLN protein modified form inhibits the reaction [Fructose results in increased expression of ACE mRNA]; APLN protein modified form inhibits the reaction [Fructose results in increased expression of AGT mRNA]; APLN protein modified form inhibits the reaction [Fructose results in increased expression of AGT protein modified form]; APLN protein modified form inhibits the reaction [Fructose results in increased expression of AGT protein]; APLN protein modified form inhibits the reaction [Fructose results in increased expression of AGTR1A mRNA]; APLN protein modified form inhibits the reaction [Fructose results in increased expression of AGTR2 mRNA] CTD PMID:30710622 NCBI chr  X:134,856,719...134,866,210
Ensembl chr  X:134,856,726...134,866,210 		JBrowse link
G Aplnr apelin receptor decreases expression
multiple interactions		 EXP Fructose results in decreased expression of APLNR mRNA
APLN protein modified form inhibits the reaction [Fructose results in decreased expression of APLNR mRNA]		 CTD PMID:30710622 NCBI chr 3:72,540,538...72,544,183
Ensembl chr 3:72,540,538...72,544,182 		JBrowse link
G Apoa1 apolipoprotein A1 increases expression
multiple interactions
decreases expression		 EXP
ISO		 Fructose results in increased expression of APOA1 mRNA; Fructose results in increased expression of APOA1 protein
Plant Preparations inhibits the reaction [Fructose results in decreased expression of APOA1 protein]
[bisphenol A co-treated with Fructose] results in increased expression of APOA1 protein		 CTD PMID:9322794 PMID:23142792 PMID:27531227 NCBI chr 8:50,525,091...50,526,875
Ensembl chr 8:50,525,091...50,526,875 		JBrowse link
G Apoa4 apolipoprotein A4 increases expression ISO Fructose results in increased expression of APOA4 mRNA CTD PMID:11983814 NCBI chr 8:50,536,983...50,539,371
Ensembl chr 8:50,537,009...50,539,376 		JBrowse link
G Apob apolipoprotein B multiple interactions
increases expression		 EXP
ISO		 [Fructose co-treated with Copper deficiency] results in decreased expression of APOB mRNA; Atorvastatin inhibits the reaction [Fructose results in increased expression of APOB protein]; gadolinium chloride promotes the reaction [[Fructose co-treated with Copper deficiency] results in decreased expression of APOB mRNA]
[FGF21 gene mutant form results in increased susceptibility to Fructose] which results in decreased expression of APOB mRNA; Plant Preparations inhibits the reaction [Fructose results in increased expression of APOB protein]
Fructose results in increased expression of APOB mRNA; Fructose results in increased expression of APOB protein		 CTD PMID:8415773 PMID:12065722 PMID:25813056 PMID:27531227 PMID:28123933 NCBI chr 6:33,176,826...33,216,381
Ensembl chr 6:33,176,778...33,224,997 		JBrowse link
G Atf4 activating transcription factor 4 increases expression EXP Fructose results in increased expression of ATF4 mRNA CTD PMID:15150374 NCBI chr 7:121,480,723...121,482,781
Ensembl chr 7:121,480,723...121,482,772 		JBrowse link
G Atp1b1 ATPase Na+/K+ transporting subunit beta 1 decreases expression EXP Fructose results in decreased expression of ATP1B1 protein CTD PMID:26930160 NCBI chr13:82,737,161...82,757,681
Ensembl chr13:82,737,159...82,758,004 		JBrowse link
G Atp2a2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 multiple interactions ISO [Fructose co-treated with Dietary Fats] results in decreased expression of ATP2A2 mRNA; troxerutin inhibits the reaction [[Fructose co-treated with Dietary Fats] results in decreased expression of ATP2A2 mRNA] CTD PMID:28916335 NCBI chr12:39,553,903...39,603,326
Ensembl chr12:39,553,903...39,603,326 		JBrowse link
G Atp5mf ATP synthase membrane subunit f multiple interactions
increases expression		 EXP [Fructose co-treated with bisphenol A] results in decreased expression of ATP5MF protein
Fructose results in increased expression of ATP5MF protein		 CTD PMID:26930160 NCBI chr12:11,191,799...11,198,369
Ensembl chr12:11,191,812...11,198,369 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression
multiple interactions		 ISO Fructose results in increased expression of BAX protein
[Fructose co-treated with Dietary Fats] results in increased expression of BAX mRNA; [Fructose co-treated with Dietary Fats] results in increased expression of BAX protein; Plant Preparations inhibits the reaction [Fructose results in increased expression of BAX protein]; troxerutin inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of BAX mRNA]; troxerutin inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of BAX protein]		 CTD PMID:27531227 PMID:28916335 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
increases expression
multiple interactions		 ISO
EXP		 Fructose results in decreased expression of BCL2 protein
Fructose results in increased expression of BCL2 mRNA
2-(3-(4-ethoxybenzyl)-4-chlorophenyl)-6-hydroxymethyltetrahydro-2H-pyran-3,4,5-triol inhibits the reaction [[Fructose co-treated with Dietary Fats] results in decreased expression of BCL2 protein]; [Atorvastatin co-treated with 2-(3-(4-ethoxybenzyl)-4-chlorophenyl)-6-hydroxymethyltetrahydro-2H-pyran-3,4,5-triol] inhibits the reaction [[Fructose co-treated with Dietary Fats] results in decreased expression of BCL2 protein]; [Fructose co-treated with Dietary Fats] results in decreased expression of BCL2 protein; Kangen-karyu inhibits the reaction [Fructose results in increased expression of BCL2 protein]
[Fructose co-treated with Dietary Fats] results in decreased expression of BCL2 mRNA; [Fructose co-treated with Dietary Fats] results in decreased expression of BCL2 protein; troxerutin inhibits the reaction [[Fructose co-treated with Dietary Fats] results in decreased expression of BCL2 mRNA]; troxerutin inhibits the reaction [[Fructose co-treated with Dietary Fats] results in decreased expression of BCL2 protein]		 CTD PMID:17883899 PMID:27531227 PMID:28916335 PMID:31655124 PMID:32259528 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374 		JBrowse link
G Calca calcitonin-related polypeptide alpha increases expression ISO Fructose results in increased expression of CALCA mRNA CTD PMID:31655124 NCBI chr 1:184,184,018...184,188,922
Ensembl chr 1:184,184,020...184,188,911 		JBrowse link
G Casp1 caspase 1 multiple interactions
increases expression		 EXP Allopurinol inhibits the reaction [Fructose results in increased expression of CASP1 protein modified form]; Allopurinol inhibits the reaction [Fructose results in increased expression of CASP1 protein]; Quercetin inhibits the reaction [Fructose results in increased expression of CASP1 protein modified form]; Quercetin inhibits the reaction [Fructose results in increased expression of CASP1 protein]; Rutin inhibits the reaction [Fructose results in increased expression of CASP1 protein]
Fructose results in increased expression of CASP1 protein; Fructose results in increased expression of CASP1 protein modified form		 CTD PMID:22426011 PMID:24491314 NCBI chr 8:2,605,743...2,614,637
Ensembl chr 8:2,604,962...2,614,631 		JBrowse link
G Casp3 caspase 3 multiple interactions
decreases expression
increases expression		 ISO
EXP		 [Fructose co-treated with Dietary Fats] results in increased expression of CASP3 mRNA; [Fructose co-treated with Dietary Fats] results in increased expression of CASP3 protein; troxerutin inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of CASP3 mRNA]; troxerutin inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of CASP3 protein]
Fructose results in decreased expression of CASP3 mRNA
imoxin inhibits the reaction [Fructose results in increased expression of CASP3 protein]		 CTD PMID:28916335 PMID:29430716 PMID:31655124 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204 		JBrowse link
G Casp7 caspase 7 multiple interactions EXP 2-(3-(4-ethoxybenzyl)-4-chlorophenyl)-6-hydroxymethyltetrahydro-2H-pyran-3,4,5-triol inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of CASP7 protein]; 2-(3-(4-ethoxybenzyl)-4-chlorophenyl)-6-hydroxymethyltetrahydro-2H-pyran-3,4,5-triol promotes the reaction [Metformin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of CASP7 protein]]; [Streptozocin co-treated with Fructose] results in increased expression of CASP7 protein; Metformin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of CASP7 protein]; Metformin promotes the reaction [2-(3-(4-ethoxybenzyl)-4-chlorophenyl)-6-hydroxymethyltetrahydro-2H-pyran-3,4,5-triol inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of CASP7 protein]] CTD PMID:30551545 NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774 		JBrowse link
G Casp9 caspase 9 multiple interactions ISO [Fructose co-treated with Dietary Fats] results in increased expression of CASP9 mRNA; [Fructose co-treated with Dietary Fats] results in increased expression of CASP9 protein; troxerutin inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of CASP9 mRNA]; troxerutin inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of CASP9 protein] CTD PMID:28916335 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778 		JBrowse link
G Cat catalase decreases expression
multiple interactions
decreases activity		 EXP
ISO		 Fructose results in decreased expression of CAT mRNA; Fructose results in decreased expression of CAT protein
[Fructose co-treated with Dietary Fats] results in decreased activity of CAT protein; troxerutin inhibits the reaction [[Fructose co-treated with Dietary Fats] results in decreased activity of CAT protein]
[Hydrochlorothiazide co-treated with Fructose] results in decreased activity of CAT protein; APLN protein modified form inhibits the reaction [Fructose results in decreased activity of CAT protein]		 CTD PMID:11817707 PMID:20470786 PMID:23707192 PMID:28916335 PMID:30710622 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058 		JBrowse link
G Cavin3 caveolae associated protein 3 multiple interactions EXP [Fructose co-treated with bisphenol A] results in increased expression of CAVIN3 protein CTD PMID:26930160 NCBI chr 1:170,317,099...170,318,688
Ensembl chr 1:170,317,113...170,318,935 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions
increases expression
increases secretion		 ISO
EXP		 [Fructose co-treated with Uric Acid] results in increased secretion of CCL2 protein; acetovanillone inhibits the reaction [Fructose results in increased secretion of CCL2 protein]; Acetylcysteine inhibits the reaction [Fructose results in increased secretion of CCL2 protein]; Allopurinol inhibits the reaction [[Fructose co-treated with Uric Acid] results in increased secretion of CCL2 protein]; Allopurinol inhibits the reaction [Fructose results in increased secretion of CCL2 protein]; Glucose inhibits the reaction [Fructose results in increased secretion of CCL2 protein]; KHK protein promotes the reaction [Fructose results in increased secretion of CCL2 protein]; Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin inhibits the reaction [Fructose results in increased secretion of CCL2 protein]; Superoxides affects the reaction [Fructose results in increased secretion of CCL2 protein]
Fructose results in increased expression of CCL2 mRNA
Fructose results in increased expression of CCL2 protein
[Dietary Fats co-treated with Fructose] results in increased expression of CCL2 protein; [FGF21 gene mutant form results in increased susceptibility to Fructose] which results in increased expression of CCL2 mRNA; [Fructose co-treated with Ethanol] results in increased expression of CCL2 mRNA; sarpogrelate inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of CCL2 protein]
2-(3-(4-ethoxybenzyl)-4-chlorophenyl)-6-hydroxymethyltetrahydro-2H-pyran-3,4,5-triol inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of and results in increased secretion of CCL2 protein]; [Copper deficiency co-treated with Fructose] results in increased expression of CCL2 protein; [Fructose co-treated with Copper deficiency] results in increased expression of CCL2 protein; [Lipopolysaccharides co-treated with Fructose co-treated with Copper deficiency] results in increased expression of CCL2 protein; [Particulate Matter co-treated with Ozone] promotes the reaction [Fructose results in increased expression of CCL2 mRNA]; [Streptozocin co-treated with Fructose] results in increased expression of and results in increased secretion of CCL2 protein; Acarbose inhibits the reaction [Fructose results in increased expression of CCL2 mRNA]; Acarbose inhibits the reaction [Fructose results in increased expression of CCL2 protein]; Deferiprone inhibits the reaction [[Lipopolysaccharides co-treated with Fructose co-treated with Copper deficiency] results in increased expression of CCL2 protein]; Deferoxamine inhibits the reaction [[Lipopolysaccharides co-treated with Fructose co-treated with Copper deficiency] results in increased expression of CCL2 protein]; Fish Oils inhibits the reaction [Fructose results in increased expression of CCL2 protein]; gadolinium chloride inhibits the reaction [[Fructose co-treated with Copper deficiency] results in increased expression of CCL2 protein]; Metformin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of and results in increased secretion of CCL2 protein]; Ozone promotes the reaction [Fructose results in increased expression of CCL2 mRNA]; Particulate Matter promotes the reaction [Fructose results in increased expression of CCL2 mRNA]
Fructose results in increased expression of CCL2 mRNA; Fructose results in increased expression of CCL2 protein		 CTD PMID:15752949 PMID:17133782 PMID:19158351 PMID:21781943 PMID:23968387 PMID:25813056 PMID:26824242 PMID:26858005 PMID:28123933 PMID:30551545 PMID:31655124 PMID:31672515 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870 		JBrowse link
G Ccl3 C-C motif chemokine ligand 3 multiple interactions ISO [FGF21 gene mutant form results in increased susceptibility to Fructose] which results in increased expression of CCL3 mRNA CTD PMID:28123933 NCBI chr10:70,869,516...70,871,066
Ensembl chr10:70,869,513...70,871,066 		JBrowse link
G Ccn2 cellular communication network factor 2 multiple interactions
increases expression		 EXP betanin inhibits the reaction [Fructose results in increased expression of CCN2 protein] CTD PMID:25559852 NCBI chr 1:21,851,657...21,854,773
Ensembl chr 1:21,851,660...21,854,773 		JBrowse link
G Cd163 CD163 molecule multiple interactions EXP
ISO		 [gadolinium chloride co-treated with Fructose co-treated with Copper deficiency] results in decreased expression of CD163 mRNA
[Fructose co-treated with Ethanol] results in increased expression of CD163 mRNA		 CTD PMID:25813056 PMID:26858005 NCBI chr 4:156,752,063...156,785,467
Ensembl chr 4:156,752,082...156,785,467 		JBrowse link
G Cd36 CD36 molecule decreases expression
multiple interactions		 ISO
EXP		 Fructose results in decreased expression of CD36 protein
2-(3-(4-ethoxybenzyl)-4-chlorophenyl)-6-hydroxymethyltetrahydro-2H-pyran-3,4,5-triol inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of CD36 protein]; [Atorvastatin co-treated with 2-(3-(4-ethoxybenzyl)-4-chlorophenyl)-6-hydroxymethyltetrahydro-2H-pyran-3,4,5-triol] inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of CD36 protein]; [Fructose co-treated with Dietary Fats] results in increased expression of CD36 protein		 CTD PMID:28257781 PMID:32259528 NCBI chr 4:14,150,309...14,191,498
Ensembl chr 4:14,001,761...14,249,749 		JBrowse link
G Cd68 Cd68 molecule multiple interactions EXP
ISO		 [Dietary Fats co-treated with Fructose] results in increased expression of CD68 mRNA; [gadolinium chloride co-treated with Fructose co-treated with Copper deficiency] results in decreased expression of CD68 mRNA; [gadolinium chloride co-treated with Fructose co-treated with Copper deficiency] results in decreased expression of CD68 protein
[FGF21 gene mutant form results in increased susceptibility to Fructose] which results in increased expression of CD68 mRNA; [Fructose co-treated with Ethanol] results in increased expression of CD68 mRNA		 CTD PMID:19632207 PMID:25813056 PMID:26858005 PMID:28123933 NCBI chr10:56,268,726...56,270,605
Ensembl chr10:56,268,720...56,270,640 		JBrowse link
G Chrm2 cholinergic receptor, muscarinic 2 increases expression EXP Fructose results in increased expression of CHRM2 mRNA; Fructose results in increased expression of CHRM2 protein CTD PMID:17707055 NCBI chr 4:64,089,028...64,091,090
Ensembl chr 4:64,088,900...64,091,090 		JBrowse link
G Chrm3 cholinergic receptor, muscarinic 3 increases expression EXP Fructose results in increased expression of CHRM3 mRNA; Fructose results in increased expression of CHRM3 protein CTD PMID:17707055 NCBI chr17:63,990,599...64,463,222
Ensembl chr17:63,990,599...63,994,169 		JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex increases phosphorylation
multiple interactions		 EXP Fructose results in increased phosphorylation of CHUK protein
Quercetin inhibits the reaction [Fructose results in increased phosphorylation of CHUK protein]		 CTD PMID:24491314 NCBI chr 1:263,848,829...263,884,354
Ensembl chr 1:263,848,884...263,885,169 		JBrowse link
G Cidea cell death-inducing DFFA-like effector a multiple interactions
decreases expression		 EXP [Ozone co-treated with Fructose] results in decreased expression of CIDEA mRNA; [Particulate Matter co-treated with Fructose] results in decreased expression of CIDEA mRNA; [Particulate Matter co-treated with Ozone co-treated with Fructose] results in decreased expression of CIDEA mRNA
Fructose results in decreased expression of CIDEA mRNA		 CTD PMID:23968387 NCBI chr18:63,082,861...63,108,450
Ensembl chr18:63,098,144...63,108,051 		JBrowse link
G Cnr1 cannabinoid receptor 1 increases expression
multiple interactions		 EXP Fructose results in increased expression of CNR1 mRNA
[Fructose co-treated with Streptozocin] results in decreased expression of CNR1 mRNA; Ghrelin inhibits the reaction [[Fructose co-treated with Streptozocin] results in decreased expression of CNR1 mRNA]		 CTD PMID:18627777 PMID:31468622 NCBI chr 5:49,307,584...49,333,064
Ensembl chr 5:49,311,030...49,333,056 		JBrowse link
G Coq9 coenzyme Q9 multiple interactions EXP [Fructose co-treated with bisphenol A] results in increased expression of COQ9 protein CTD PMID:26930160 NCBI chr19:10,583,855...10,596,848
Ensembl chr19:10,583,857...10,596,851 		JBrowse link
G Cp ceruloplasmin multiple interactions EXP [Fructose co-treated with Copper deficiency] results in decreased activity of CP protein; Fructose promotes the reaction [Copper deficiency results in decreased expression of CP protein] CTD PMID:21781943 PMID:25813056 NCBI chr 2:104,744,249...104,803,034
Ensembl chr 2:104,744,461...104,799,853 		JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A multiple interactions EXP [Dietary Fats co-treated with Fructose] results in increased expression of CPT1A mRNA; [Fructose co-treated with Copper deficiency] results in decreased expression of CPT1A mRNA; [Fructose co-treated with Dietary Fats] results in decreased expression of CPT1A protein CTD PMID:19632207 PMID:25813056 PMID:32259528 NCBI chr 1:218,568,157...218,629,679
Ensembl chr 1:218,569,510...218,629,678 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 increases expression
multiple interactions		 EXP Fructose results in increased expression of CREB1 mRNA; Fructose results in increased expression of CREB1 protein
rosiglitazone inhibits the reaction [Fructose results in increased expression of CREB1 mRNA]; rosiglitazone inhibits the reaction [Fructose results in increased expression of CREB1 protein]		 CTD PMID:19196556 NCBI chr 9:71,229,753...71,298,994
Ensembl chr 9:71,230,108...71,293,435 		JBrowse link
G Crp C-reactive protein multiple interactions
increases expression		 EXP
ISO		 [Dietary Fats co-treated with Fructose] results in increased expression of CRP mRNA; Curcumin inhibits the reaction [Fructose results in increased expression of CRP protein]; Metformin inhibits the reaction [Fructose results in increased expression of CRP protein]; resveratrol inhibits the reaction [Fructose results in increased expression of CRP protein] CTD PMID:19632207 PMID:25108154 PMID:26713546 PMID:31672515 NCBI chr13:91,080,448...91,081,358
Ensembl chr13:91,054,974...91,093,713 		JBrowse link
G Cst3 cystatin C multiple interactions EXP [Streptozocin co-treated with Fructose] results in increased expression of CST3 protein; Metformin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of CST3 protein] CTD PMID:30551545 NCBI chr 3:143,219,671...143,223,544
Ensembl chr 3:143,219,686...143,223,615 		JBrowse link
G Cx3cl1 C-X3-C motif chemokine ligand 1 increases expression ISO Fructose results in increased expression of CX3CL1 mRNA CTD PMID:31655124 NCBI chr19:10,644,267...10,654,861
Ensembl chr19:10,644,244...10,653,800 		JBrowse link
G Cybb cytochrome b-245 beta chain multiple interactions EXP [Dietary Fats co-treated with Fructose] results in increased expression of CYBB mRNA CTD PMID:19632207 NCBI chr  X:14,578,330...14,610,049
Ensembl chr  X:14,578,264...14,612,547 		JBrowse link
G Cycs cytochrome c, somatic multiple interactions EXP [Atorvastatin co-treated with 2-(3-(4-ethoxybenzyl)-4-chlorophenyl)-6-hydroxymethyltetrahydro-2H-pyran-3,4,5-triol] inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of CYCS protein]; [Fructose co-treated with Dietary Fats] results in increased expression of CYCS protein CTD PMID:32259528 NCBI chr 4:80,331,226...80,333,326
Ensembl chr 4:80,331,227...80,333,326 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO [Dietary Fats co-treated with Fructose] results in increased expression of CYP1A1 mRNA CTD PMID:26102010 PMID:29416063 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions ISO [Dietary Fats co-treated with Fructose] results in increased expression of CYP1A2 mRNA; alpha-Tocopherol inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of CYP1A2 mRNA]; tetrahydrocurcumin inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of CYP1A2 mRNA] CTD PMID:26102010 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 multiple interactions ISO [Dietary Fats co-treated with Fructose] results in increased expression of CYP1B1 mRNA; [Dietary Fats co-treated with Fructose] results in increased expression of CYP1B1 protein; tetrahydrocurcumin inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of CYP1B1 mRNA]; tetrahydrocurcumin inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of CYP1B1 protein] CTD PMID:26102010 NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722 		JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 multiple interactions ISO [Dietary Fats co-treated with Fructose] results in increased expression of CYP2C29 mRNA; [Dietary Fats co-treated with Fructose] results in increased expression of CYP2C29 protein; alpha-Tocopherol inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of CYP2C29 protein]; tetrahydrocurcumin inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of CYP2C29 mRNA]; tetrahydrocurcumin inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of CYP2C29 protein] CTD PMID:26102010 NCBI chr 1:147,236,480...147,307,988 JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 decreases expression
increases expression
multiple interactions		 ISO Fructose results in decreased expression of CYP2E1 protein
Fructose results in increased expression of CYP2E1 protein
Ethanol promotes the reaction [Fructose results in increased expression of CYP2E1 protein]		 CTD PMID:26858005 PMID:28257781 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542 		JBrowse link
G Cyp4a1 cytochrome P450, family 4, subfamily a, polypeptide 1 multiple interactions EXP [Fructose co-treated with Copper deficiency] results in decreased expression of CYP4A1 mRNA; gadolinium chloride promotes the reaction [[Fructose co-treated with Copper deficiency] results in decreased expression of CYP4A1 mRNA] CTD PMID:25813056 NCBI chr 5:134,492,734...134,507,158
Ensembl chr 5:134,492,756...134,507,154 		JBrowse link
G Ddt D-dopachrome tautomerase decreases expression
multiple interactions		 EXP Fructose results in decreased expression of DDT protein
[Fructose co-treated with bisphenol A] results in increased expression of DDT protein		 CTD PMID:26930160 NCBI chr20:13,827,153...13,829,624
Ensembl chr20:13,827,132...13,831,588 		JBrowse link
G Dek DEK proto-oncogene multiple interactions ISO DEK protein results in decreased chemical synthesis of and results in decreased secretion of Fructose CTD PMID:28558019 NCBI chr17:17,965,872...17,987,836
Ensembl chr17:17,965,881...17,987,834 		JBrowse link
G Dgat1 diacylglycerol O-acyltransferase 1 multiple interactions ISO [FGF21 gene mutant form results in increased susceptibility to Fructose] which results in increased expression of DGAT1 mRNA CTD PMID:28123933 NCBI chr 7:117,566,363...117,576,735
Ensembl chr 7:117,566,368...117,576,737 		JBrowse link
G Dgat2 diacylglycerol O-acyltransferase 2 multiple interactions ISO [FGF21 gene mutant form results in increased susceptibility to Fructose] which results in decreased expression of DGAT2 mRNA CTD PMID:28123933 NCBI chr 1:164,113,459...164,143,818
Ensembl chr 1:164,113,459...164,143,818 		JBrowse link
G Dld dihydrolipoamide dehydrogenase multiple interactions EXP [Fructose co-treated with bisphenol A] results in decreased expression of DLD protein CTD PMID:26930160 NCBI chr 6:50,597,677...50,618,694
Ensembl chr 6:50,597,677...50,618,694 		JBrowse link
G Dpt dermatopontin multiple interactions
decreases expression		 EXP [Ozone co-treated with Fructose] results in decreased expression of DPT mRNA; [Particulate Matter co-treated with Fructose] results in decreased expression of DPT mRNA; Fructose affects the reaction [[Ozone co-treated with Particulate Matter] results in decreased expression of DPT mRNA]
Fructose results in decreased expression of DPT mRNA		 CTD PMID:23968387 NCBI chr13:83,073,307...83,102,404
Ensembl chr13:83,073,544...83,102,401 		JBrowse link
G Echs1 enoyl-CoA hydratase, short chain 1 multiple interactions EXP [Fructose co-treated with bisphenol A] results in increased expression of ECHS1 protein CTD PMID:26930160 NCBI chr 1:212,570,213...212,579,040
Ensembl chr 1:212,570,195...212,579,057
Ensembl chr 1:212,570,195...212,579,057 		JBrowse link
G Edn1 endothelin 1 increases response to substance
increases expression
multiple interactions		 EXP Fructose results in increased susceptibility to EDN1 protein
Fructose results in increased expression of EDN1 mRNA; Fructose results in increased expression of EDN1 protein modified form
KLK1 protein inhibits the reaction [Fructose results in increased expression of EDN1 mRNA]; Metformin inhibits the reaction [Fructose results in increased expression of EDN1 protein]; resveratrol inhibits the reaction [Fructose results in increased expression of EDN1 protein]		 CTD PMID:9869011 PMID:11172478 PMID:14568997 PMID:25108154 NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324 		JBrowse link
G Ednra endothelin receptor type A multiple interactions
increases expression		 EXP
ISO		 KLK1 protein inhibits the reaction [Fructose results in increased expression of EDNRA mRNA] CTD PMID:9869011 PMID:14568997 PMID:31655124 NCBI chr19:33,928,356...33,991,703
Ensembl chr19:33,928,356...33,991,703 		JBrowse link
G Eef1a2 eukaryotic translation elongation factor 1 alpha 2 multiple interactions EXP [Fructose co-treated with bisphenol A] results in decreased expression of EEF1A2 protein CTD PMID:26930160 NCBI chr 3:176,657,104...176,666,282
Ensembl chr 3:176,657,107...176,666,282 		JBrowse link
G Egf epidermal growth factor multiple interactions
increases uptake		 EXP wortmannin inhibits the reaction [EGF protein results in increased uptake of Fructose] CTD PMID:15691865 NCBI chr 2:68,820,616...68,895,537 JBrowse link
G Eif2ak2 eukaryotic translation initiation factor 2-alpha kinase 2 increases expression
multiple interactions		 EXP Fructose results in increased expression of EIF2AK2 protein
imoxin inhibits the reaction [Fructose results in increased expression of EIF2AK2 protein]		 CTD PMID:29430716 NCBI chr 6:1,428,845...1,466,193
Ensembl chr 6:1,428,834...1,466,201 		JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 increases phosphorylation
multiple interactions		 ISO Fructose results in increased phosphorylation of EIF2AK3 protein
Phenylbutyrates inhibits the reaction [Fructose results in increased phosphorylation of EIF2AK3 protein]		 CTD PMID:22698815 NCBI chr 4:98,648,513...98,709,695
Ensembl chr 4:98,648,545...98,709,694 		JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha increases phosphorylation
multiple interactions		 ISO Fructose results in increased phosphorylation of EIF2S1 protein
Phenylbutyrates inhibits the reaction [Fructose results in increased phosphorylation of EIF2S1 protein]		 CTD PMID:22698815 NCBI chr 6:102,048,372...102,073,041
Ensembl chr 6:102,048,372...102,073,041 		JBrowse link
G Elovl6 ELOVL fatty acid elongase 6 increases expression ISO Fructose results in increased expression of ELOVL6 mRNA CTD PMID:15066988 NCBI chr 2:234,187,490...234,296,124
Ensembl chr 2:234,189,105...234,296,145
Ensembl chr 2:234,189,105...234,296,145 		JBrowse link
G Entpd2 ectonucleoside triphosphate diphosphohydrolase 2 decreases expression EXP Fructose results in decreased expression of ENTPD2 mRNA CTD PMID:15150374 NCBI chr 3:2,617,795...2,623,818
Ensembl chr 3:2,617,805...2,623,445 		JBrowse link
G Ezr ezrin multiple interactions EXP [Fructose co-treated with bisphenol A] results in increased expression of EZR protein CTD PMID:26930160 NCBI chr 1:47,287,872...47,331,412
Ensembl chr 1:47,287,874...47,331,412 		JBrowse link
G F3 coagulation factor III, tissue factor increases expression ISO Fructose results in increased expression of F3 mRNA CTD PMID:31655124 NCBI chr 2:225,310,686...225,322,281
Ensembl chr 2:225,310,624...225,322,272 		JBrowse link
G Fabp3 fatty acid binding protein 3 multiple interactions EXP [Fructose co-treated with bisphenol A] results in increased expression of FABP3 protein CTD PMID:26930160 NCBI chr 5:148,528,854...148,535,597
Ensembl chr 5:148,528,725...148,535,565 		JBrowse link
G Fabp4 fatty acid binding protein 4 multiple interactions EXP [Fructose co-treated with bisphenol A] results in increased expression of FABP4 protein CTD PMID:26930160 NCBI chr 2:93,792,666...93,797,267
Ensembl chr 2:93,792,601...93,797,305 		JBrowse link
G Fas Fas cell surface death receptor decreases expression ISO Fructose results in decreased expression of FAS mRNA CTD PMID:31655124 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790 		JBrowse link
G Faslg Fas ligand increases expression ISO Fructose results in increased expression of FASLG mRNA CTD PMID:31655124 NCBI chr13:79,696,811...79,717,581
Ensembl chr13:79,698,445...79,705,705 		JBrowse link
G Fasn fatty acid synthase multiple interactions
increases expression
increases activity		 EXP
ISO		 2-(3-(4-ethoxybenzyl)-4-chlorophenyl)-6-hydroxymethyltetrahydro-2H-pyran-3,4,5-triol inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of FASN protein]; [Atorvastatin co-treated with 2-(3-(4-ethoxybenzyl)-4-chlorophenyl)-6-hydroxymethyltetrahydro-2H-pyran-3,4,5-triol] inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of FASN protein]; [Copper deficiency co-treated with Fructose] results in increased expression of FASN protein; [Fenofibrate co-treated with Resveratrol] inhibits the reaction [Fructose results in increased expression of FASN mRNA]; [Fructose co-treated with Dietary Fats] results in increased expression of FASN protein; [gadolinium chloride co-treated with Fructose co-treated with Copper deficiency] results in decreased expression of FASN mRNA; Atorvastatin inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of FASN protein]; Fenofibrate inhibits the reaction [Fructose results in increased expression of FASN mRNA]; Resveratrol inhibits the reaction [Fructose results in increased expression of FASN mRNA]; Rosiglitazone inhibits the reaction [Fructose results in increased expression of FASN mRNA]; Tea inhibits the reaction [Fructose results in increased expression of FASN mRNA]
FGF21 gene mutant form inhibits the reaction [Fructose results in increased expression of FASN mRNA]; Phenylbutyrates inhibits the reaction [Fructose results in increased expression of FASN mRNA]; Plant Preparations inhibits the reaction [Fructose results in increased expression of FASN protein]; SCD1 gene mutant form inhibits the reaction [Fructose results in increased expression of FASN mRNA]; Triolein inhibits the reaction [SCD1 gene mutant form inhibits the reaction [Fructose results in increased expression of FASN mRNA]]; Triolein promotes the reaction [Fructose results in increased expression of FASN mRNA]
Fructose results in increased expression of FASN mRNA; Fructose results in increased expression of FASN protein
Fructose results in increased activity of FASN protein		 CTD PMID:8759368 PMID:9566986 PMID:12065722 PMID:15066988 PMID:18346472 PMID:19053045 PMID:19193814 PMID:19196556 PMID:21781943 PMID:22698815 PMID:25813056 PMID:26973390 PMID:27531227 PMID:28123933 PMID:28257781 PMID:32259528 NCBI chr10:109,987,735...110,005,901
Ensembl chr10:109,987,735...110,005,901 		JBrowse link
G Fbp1 fructose-bisphosphatase 1 increases activity
increases expression
multiple interactions		 EXP Fructose results in increased activity of FBP1 protein
Fructose results in increased expression of FBP1 mRNA
Vanadates inhibits the reaction [Fructose results in increased activity of FBP1 protein]		 CTD PMID:15150374 PMID:16920846 PMID:18346472 NCBI chr17:396,175...417,480
Ensembl chr17:396,180...417,480 		JBrowse link
G Fgf21 fibroblast growth factor 21 multiple interactions
increases expression
increases response to substance
increases secretion		 ISO [FGF21 gene mutant form results in increased susceptibility to Fructose] which results in decreased abundance of Blood Glucose; [FGF21 gene mutant form results in increased susceptibility to Fructose] which results in decreased expression of APOB mRNA; [FGF21 gene mutant form results in increased susceptibility to Fructose] which results in decreased expression of DGAT2 mRNA; [FGF21 gene mutant form results in increased susceptibility to Fructose] which results in increased expression of CCL2 mRNA; [FGF21 gene mutant form results in increased susceptibility to Fructose] which results in increased expression of CCL3 mRNA; [FGF21 gene mutant form results in increased susceptibility to Fructose] which results in increased expression of CD68 mRNA; [FGF21 gene mutant form results in increased susceptibility to Fructose] which results in increased expression of DGAT1 mRNA; [FGF21 gene mutant form results in increased susceptibility to Fructose] which results in increased expression of MMP2 mRNA; [FGF21 gene mutant form results in increased susceptibility to Fructose] which results in increased expression of TGFB1 mRNA; [FGF21 gene mutant form results in increased susceptibility to Fructose] which results in increased expression of TGFB2 mRNA; FGF21 gene mutant form inhibits the reaction [Fructose results in increased expression of ACACA mRNA]; FGF21 gene mutant form inhibits the reaction [Fructose results in increased expression of ACACB mRNA]; FGF21 gene mutant form inhibits the reaction [Fructose results in increased expression of ALDOB mRNA]; FGF21 gene mutant form inhibits the reaction [Fructose results in increased expression of FASN mRNA]; FGF21 gene mutant form inhibits the reaction [Fructose results in increased expression of KHK mRNA]; FGF21 gene mutant form inhibits the reaction [Fructose results in increased expression of MLXIPL mRNA alternative form]; FGF21 gene mutant form inhibits the reaction [Fructose results in increased expression of MTTP mRNA]; FGF21 gene mutant form inhibits the reaction [Fructose results in increased expression of PKLR mRNA]; FGF21 gene mutant form inhibits the reaction [Fructose results in increased expression of SCD1 mRNA]; FGF21 gene mutant form inhibits the reaction [Fructose results in increased secretion of very low density lipoprotein triglyceride]; MLXIPL gene mutant form inhibits the reaction [Fructose results in increased expression of FGF21 mRNA]; MLXIPL gene mutant form inhibits the reaction [Fructose results in increased secretion of FGF21 protein] CTD PMID:28123933 NCBI chr 1:101,595,579...101,596,822
Ensembl chr 1:101,595,579...101,596,822 		JBrowse link
G Fhl2 four and a half LIM domains 2 multiple interactions EXP [Fructose co-treated with bisphenol A] results in decreased expression of FHL2 protein CTD PMID:26930160 NCBI chr 9:49,920,611...49,994,906
Ensembl chr 9:49,920,854...49,950,093 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression		 EXP Dactinomycin inhibits the reaction [Fructose results in increased expression of FOS mRNA] CTD PMID:11123204 PMID:11557636 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299 		JBrowse link
G Foxo1 forkhead box O1 multiple interactions
increases expression		 EXP Fructose results in increased expression of and affects the localization of FOXO1 protein; Fructose results in increased expression of and results in increased phosphorylation of FOXO1 protein; Quercetin inhibits the reaction [Fructose results in increased expression of and affects the localization of FOXO1 protein]; Quercetin inhibits the reaction [Fructose results in increased expression of and results in increased phosphorylation of FOXO1 protein]; Rosiglitazone inhibits the reaction [Fructose results in increased expression of FOXO1 mRNA] CTD PMID:19196556 PMID:23533474 NCBI chr 2:141,451,234...141,527,016
Ensembl chr 2:141,451,234...141,527,016 		JBrowse link
G Fth1 ferritin heavy chain 1 increases expression EXP Fructose results in increased expression of FTH1 protein CTD PMID:26930160 NCBI chr 1:226,030,940...226,033,228
Ensembl chr 1:226,030,938...226,033,228 		JBrowse link
G G6pc1 glucose-6-phosphatase catalytic subunit 1 multiple interactions
increases expression		 EXP Rosiglitazone inhibits the reaction [Fructose results in increased expression of G6PC1 mRNA]; Rosiglitazone inhibits the reaction [Fructose results in increased expression of G6PC1 protein]
Fructose results in increased expression of G6PC1 mRNA; Fructose results in increased expression of G6PC1 protein		 CTD PMID:14988444 PMID:15150374 PMID:16920846 PMID:18346472 PMID:18556366 PMID:19196556 NCBI chr10:89,286,009...89,296,213
Ensembl chr10:89,285,855...89,296,213 		JBrowse link
G G6pd glucose-6-phosphate dehydrogenase increases activity
multiple interactions
decreases expression		 EXP Fructose results in increased activity of G6PD protein
Glutamine inhibits the reaction [Fructose results in decreased expression of G6PD protein]		 CTD PMID:18346472 PMID:31233715 NCBI chr  X:156,274,800...156,293,935
Ensembl chr  X:156,274,800...156,293,926 		JBrowse link
G Gcg glucagon multiple interactions EXP GCG protein affects the reaction [Fructose affects the degradation of PKLR mRNA] CTD PMID:2414297 NCBI chr 3:48,442,635...48,451,650
Ensembl chr 3:48,442,635...48,451,650 		JBrowse link
G Gck glucokinase increases activity EXP Fructose results in increased activity of GCK protein CTD PMID:20470786 NCBI chr14:86,149,146...86,191,589
Ensembl chr14:86,148,928...86,190,659 		JBrowse link
G Gckr glucokinase regulator increases expression EXP Fructose results in increased expression of GCKR mRNA CTD PMID:18346472 NCBI chr 6:26,355,296...26,385,761
Ensembl chr 6:26,355,296...26,385,761 		JBrowse link
G Ghrl ghrelin and obestatin prepropeptide increases expression EXP Fructose results in increased expression of GHRL protein CTD PMID:18627777 NCBI chr 4:145,674,157...145,678,066
Ensembl chr 4:145,674,157...145,678,066 		JBrowse link
G Glp1r glucagon-like peptide 1 receptor multiple interactions EXP [Fructose co-treated with Streptozocin] results in decreased expression of GLP1R mRNA; Ghrelin inhibits the reaction [[Fructose co-treated with Streptozocin] results in decreased expression of GLP1R mRNA] CTD PMID:31468622 NCBI chr20:9,586,075...9,626,228
Ensembl chr20:9,586,075...9,626,228 		JBrowse link
G Glul glutamate-ammonia ligase decreases expression
multiple interactions		 EXP Fructose results in decreased expression of GLUL protein
Allopurinol inhibits the reaction [Fructose results in decreased expression of GLUL protein]; Quercetin inhibits the reaction [Fructose results in decreased expression of GLUL protein]		 CTD PMID:24491314 NCBI chr13:71,331,052...71,340,207
Ensembl chr13:71,331,052...71,340,229 		JBrowse link
G Gnat3 G protein subunit alpha transducin 3 affects response to substance ISO GNAT3 protein affects the susceptibility to Fructose CTD PMID:16740645 NCBI chr 4:13,827,764...13,878,126
Ensembl chr 4:13,827,756...13,878,126 		JBrowse link
G Gnmt glycine N-methyltransferase multiple interactions ISO [Dietary Fats co-treated with Fructose] results in increased expression of GNMT mRNA CTD PMID:29416063 NCBI chr 9:16,565,274...16,568,626
Ensembl chr 9:16,565,225...16,568,627 		JBrowse link
G Gpam glycerol-3-phosphate acyltransferase, mitochondrial multiple interactions
increases expression		 EXP [Folic Acid affects the susceptibility to Fructose] which affects the expression of GPAM mRNA; Atorvastatin inhibits the reaction [Fructose results in increased expression of GPAM mRNA] CTD PMID:18346472 PMID:19053045 PMID:31612177 NCBI chr 1:275,843,823...275,906,880
Ensembl chr 1:275,846,819...275,906,686 		JBrowse link
G Gpld1 glycosylphosphatidylinositol specific phospholipase D1 increases expression ISO Fructose results in increased expression of GPLD1 protein CTD PMID:16219662 NCBI chr17:42,085,027...42,131,344
Ensembl chr17:42,085,028...42,127,678 		JBrowse link
G Gpt glutamic--pyruvic transaminase increases activity
multiple interactions		 ISO
EXP		 Fructose results in increased activity of GPT protein
2-(3-(4-ethoxybenzyl)-4-chlorophenyl)-6-hydroxymethyltetrahydro-2H-pyran-3,4,5-triol inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of GPT protein]; [2-(3-(4-ethoxybenzyl)-4-chlorophenyl)-6-hydroxymethyltetrahydro-2H-pyran-3,4,5-triol co-treated with Atorvastatin] inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of GPT protein]; [Fructose co-treated with Dietary Fats] results in increased expression of GPT protein; Atorvastatin inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of GPT protein]
[Fructose co-treated with Ethanol] results in increased expression of GPT protein; Plant Preparations inhibits the reaction [Fructose results in increased activity of GPT protein]		 CTD PMID:26858005 PMID:27531227 PMID:32259528 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931 		JBrowse link
G Gpx1 glutathione peroxidase 1 decreases expression EXP Fructose results in decreased expression of GPX1 mRNA CTD PMID:16815490 PMID:20470786 NCBI chr 8:117,117,430...117,118,528
Ensembl chr 8:117,117,430...117,118,522 		JBrowse link
G Gpx4 glutathione peroxidase 4 decreases expression EXP Fructose results in decreased expression of GPX4 protein CTD PMID:21781943 NCBI chr 7:12,516,357...12,519,154
Ensembl chr 7:12,516,352...12,519,154 		JBrowse link
G Gsr glutathione-disulfide reductase increases activity EXP Fructose results in increased activity of GSR protein CTD PMID:17710547 NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361 		JBrowse link
G Hamp hepcidin antimicrobial peptide multiple interactions EXP [Fructose co-treated with Copper deficiency] results in decreased expression of HAMP protein CTD PMID:25813056 NCBI chr 1:89,368,021...89,369,960
Ensembl chr 1:89,368,021...89,369,960 		JBrowse link
G Havcr1 hepatitis A virus cellular receptor 1 multiple interactions EXP 2-(3-(4-ethoxybenzyl)-4-chlorophenyl)-6-hydroxymethyltetrahydro-2H-pyran-3,4,5-triol inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of HAVCR1 protein]; 2-(3-(4-ethoxybenzyl)-4-chlorophenyl)-6-hydroxymethyltetrahydro-2H-pyran-3,4,5-triol promotes the reaction [Metformin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of HAVCR1 protein]]; [Streptozocin co-treated with Fructose] results in increased expression of HAVCR1 protein; Metformin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of HAVCR1 protein]; Metformin promotes the reaction [2-(3-(4-ethoxybenzyl)-4-chlorophenyl)-6-hydroxymethyltetrahydro-2H-pyran-3,4,5-triol inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of HAVCR1 protein]] CTD PMID:30551545 NCBI chr10:31,813,819...31,860,934
Ensembl chr10:31,813,814...31,848,379 		JBrowse link
G Hbb hemoglobin subunit beta multiple interactions EXP Fructose promotes the reaction [Glucose binds to HBB protein]; geraniol inhibits the reaction [Fructose promotes the reaction [Glucose binds to HBB protein]]; Pioglitazone inhibits the reaction [Fructose promotes the reaction [Glucose binds to HBB protein]] CTD PMID:25679220 NCBI chr 1:168,971,269...168,972,680
Ensembl chr 1:168,971,274...168,972,725 		JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase multiple interactions
increases expression		 EXP [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in decreased activity of SIRT1 protein] inhibits the reaction [Fructose results in increased expression of HMGCR mRNA]; [Niacinamide results in decreased activity of SIRT1 protein] inhibits the reaction [Fructose results in increased expression of HMGCR mRNA]; Rotenone inhibits the reaction [Fructose results in increased expression of HMGCR mRNA]; Tea inhibits the reaction [Fructose results in increased expression of HMGCR mRNA] CTD PMID:19193814 PMID:21212096 NCBI chr 2:27,480,224...27,500,654
Ensembl chr 2:27,480,226...27,500,654 		JBrowse link
G Hmgcs2 3-hydroxy-3-methylglutaryl-CoA synthase 2 multiple interactions EXP [Fructose co-treated with Copper deficiency] results in decreased expression of HMGCS2 mRNA; gadolinium chloride promotes the reaction [[Fructose co-treated with Copper deficiency] results in decreased expression of HMGCS2 mRNA] CTD PMID:25813056 NCBI chr 2:200,452,623...200,480,785
Ensembl chr 2:200,452,624...200,479,423 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression		 EXP
ISO		 2-(3-(4-ethoxybenzyl)-4-chlorophenyl)-6-hydroxymethyltetrahydro-2H-pyran-3,4,5-triol inhibits the reaction [[Fructose co-treated with Dietary Fats] results in decreased expression of HMOX1 protein]; [Atorvastatin co-treated with 2-(3-(4-ethoxybenzyl)-4-chlorophenyl)-6-hydroxymethyltetrahydro-2H-pyran-3,4,5-triol] inhibits the reaction [[Fructose co-treated with Dietary Fats] results in decreased expression of HMOX1 protein]; [Curcumin co-treated with Fructose] results in increased expression of HMOX1 protein; [Fructose co-treated with Dietary Fats] results in decreased expression of HMOX1 protein; [Hemin co-treated with Fructose] results in increased expression of HMOX1 protein; Atorvastatin inhibits the reaction [[Fructose co-treated with Dietary Fats] results in decreased expression of HMOX1 protein]; caffeic acid phenethyl ester inhibits the reaction [Fructose results in increased expression of HMOX1 protein]
Fructose results in increased expression of HMOX1 mRNA		 CTD PMID:24508943 PMID:25268984 PMID:28257781 PMID:31655124 PMID:32259528 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456 		JBrowse link
G Hnf4a hepatocyte nuclear factor 4, alpha multiple interactions
decreases expression		 ISO
EXP		 Cerulenin inhibits the reaction [Fructose results in decreased expression of HNF4A mRNA]
Fructose results in decreased expression of HNF4A mRNA; Fructose results in decreased expression of HNF4A protein
Berberine inhibits the reaction [Fructose results in decreased expression of HNF4A mRNA]; Berberine inhibits the reaction [Fructose results in decreased expression of HNF4A protein]; rosiglitazone inhibits the reaction [Fructose results in decreased expression of HNF4A mRNA]		 CTD PMID:17992261 PMID:18563319 PMID:19196556 NCBI chr 3:159,902,441...159,965,003
Ensembl chr 3:159,902,441...159,965,003 		JBrowse link
G Hnrnpa2b1 heterogeneous nuclear ribonucleoprotein A2/B1 multiple interactions
decreases expression		 EXP [Fructose co-treated with bisphenol A] results in increased expression of HNRNPA2B1 protein
Fructose results in decreased expression of HNRNPA2B1 protein		 CTD PMID:26930160 NCBI chr 4:81,237,496...81,241,281
Ensembl chr 4:81,237,496...81,241,282 		JBrowse link
G Hnrnpa3 heterogeneous nuclear ribonucleoprotein A3 multiple interactions EXP [Fructose co-treated with bisphenol A] results in increased expression of HNRNPA3 protein CTD PMID:26930160 NCBI chr 3:62,481,222...62,491,356
Ensembl chr 3:62,481,323...62,487,227 		JBrowse link
G Hnrnpk heterogeneous nuclear ribonucleoprotein K multiple interactions EXP [Fructose co-treated with bisphenol A] results in increased expression of HNRNPK protein CTD PMID:26930160 NCBI chr17:6,664,730...6,676,753
Ensembl chr17:6,665,659...6,676,654 		JBrowse link
G Hoxc9 homeobox C9 multiple interactions
decreases expression		 EXP [Ozone co-treated with Fructose] results in decreased expression of HOXC9 mRNA; [Particulate Matter co-treated with Ozone co-treated with Fructose] results in decreased expression of HOXC9 mRNA; Fructose affects the reaction [Particulate Matter results in decreased expression of HOXC9 mRNA]
Fructose results in decreased expression of HOXC9 mRNA		 CTD PMID:23968387 NCBI chr 7:144,592,462...144,598,807
Ensembl chr 7:144,595,960...144,598,632 		JBrowse link
G Hprt1 hypoxanthine phosphoribosyltransferase 1 decreases expression ISO Fructose results in decreased expression of HPRT1 mRNA CTD PMID:31655124 NCBI chr  X:158,196,640...158,228,815
Ensembl chr  X:158,197,149...158,228,749
Ensembl chr  X:158,197,149...158,228,749 		JBrowse link
G Hspa1b heat shock protein family A (Hsp70) member 1B increases expression EXP Fructose results in increased expression of HSPA1B mRNA CTD PMID:15150374 NCBI chr20:4,877,638...4,880,112
Ensembl chr20:2,699,712...2,701,815 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression
multiple interactions		 ISO Fructose results in increased expression of HSPA5 mRNA; Fructose results in increased expression of HSPA5 protein
Phenylbutyrates inhibits the reaction [Fructose results in increased expression of HSPA5 protein]		 CTD PMID:22698815 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762 		JBrowse link
G Hspd1 heat shock protein family D (Hsp60) member 1 multiple interactions
increases expression		 EXP Amlodipine inhibits the reaction [Fructose results in increased expression of HSPD1 protein]; rosiglitazone inhibits the reaction [Fructose results in increased expression of HSPD1 protein] CTD PMID:18948349 PMID:26930160 NCBI chr 9:61,680,529...61,691,202
Ensembl chr 9:61,680,530...61,690,956 		JBrowse link
G Hspe1 heat shock protein family E (Hsp10) member 1 multiple interactions EXP [Fructose co-treated with bisphenol A] results in increased expression of HSPE1 protein CTD PMID:26930160 NCBI chr 9:61,691,246...61,724,948
Ensembl chr 9:61,692,154...61,694,599 		JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions
increases expression		 ISO
EXP		 2,2'-(hydroxynitrosohydrazono)bis-ethanamine inhibits the reaction [Fructose results in increased expression of ICAM1 protein]; Adenosine Triphosphate inhibits the reaction [Fructose results in increased expression of ICAM1 protein]
Metformin inhibits the reaction [Fructose results in increased expression of ICAM1 protein modified form]; resveratrol inhibits the reaction [Fructose results in increased expression of ICAM1 protein modified form]
Fructose results in increased expression of ICAM1 mRNA; Fructose results in increased expression of ICAM1 protein		 CTD PMID:18508964 PMID:25108154 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059 		JBrowse link
G Idh3b isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit beta decreases expression EXP Fructose results in decreased expression of IDH3B protein CTD PMID:26930160 NCBI chr 3:122,808,564...122,813,638
Ensembl chr 3:122,808,564...122,813,583 		JBrowse link
G Igfbp3 insulin-like growth factor binding protein 3 multiple interactions EXP [Fructose co-treated with Ozone co-treated with Particulate Matter] results in decreased expression of IGFBP3 mRNA; [Fructose co-treated with Ozone] results in decreased expression of IGFBP3 mRNA; [Particulate Matter co-treated with Fructose] results in decreased expression of IGFBP3 mRNA; Fructose affects the reaction [Particulate Matter results in decreased expression of IGFBP3 mRNA] CTD PMID:23968387 NCBI chr14:87,457,647...87,465,374
Ensembl chr14:87,457,647...87,465,374 		JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta increases phosphorylation
multiple interactions		 EXP Fructose results in increased phosphorylation of IKBKB protein
Allopurinol inhibits the reaction [Fructose results in increased phosphorylation of IKBKB protein]; Quercetin inhibits the reaction [Fructose results in increased phosphorylation of IKBKB protein]		 CTD PMID:24491314 NCBI chr16:74,177,233...74,230,809
Ensembl chr16:74,177,215...74,230,815 		JBrowse link
G Il10 interleukin 10 multiple interactions
decreases expression		 EXP [Fructose co-treated with Ozone co-treated with Particulate Matter] results in decreased expression of IL10 mRNA; Fructose affects the reaction [Ozone results in decreased expression of IL10 mRNA]; Fructose affects the reaction [Particulate Matter results in decreased expression of IL10 mRNA]
Fructose results in decreased expression of IL10 mRNA		 CTD PMID:23968387 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392 		JBrowse link
G Il18 interleukin 18 multiple interactions
increases expression		 EXP Allopurinol inhibits the reaction [Fructose results in increased expression of IL18 protein]; Felodipine inhibits the reaction [Fructose results in increased expression of IL18 mRNA]; Felodipine inhibits the reaction [Fructose results in increased expression of IL18 protein]; Quercetin inhibits the reaction [Fructose results in increased expression of IL18 protein]; Rutin inhibits the reaction [Fructose results in increased expression of IL18 protein]
Fructose results in increased expression of IL18 mRNA; Fructose results in increased expression of IL18 protein		 CTD PMID:18504504 PMID:22426011 NCBI chr 8:55,009,666...55,016,286
Ensembl chr 8:54,993,859...55,016,299 		JBrowse link
G Il1b interleukin 1 beta increases expression
increases secretion
multiple interactions		 EXP
ISO		 Fructose results in increased expression of IL1B protein
Fructose results in increased secretion of IL1B protein
[Fructose co-treated with Ethanol] results in increased expression of IL1B mRNA
[gadolinium chloride co-treated with Fructose co-treated with Copper deficiency] results in decreased expression of IL1B mRNA; Allopurinol inhibits the reaction [Fructose results in increased expression of IL1B protein]; geraniol inhibits the reaction [Fructose results in increased expression of IL1B protein]; geraniol inhibits the reaction [Fructose results in increased secretion of IL1B protein]; Pioglitazone inhibits the reaction [Fructose results in increased secretion of IL1B protein]; PTMA protein inhibits the reaction [Fructose results in increased expression of IL1B protein]; Quercetin inhibits the reaction [Fructose results in increased expression of IL1B protein]; Rutin inhibits the reaction [Fructose results in increased expression of IL1B protein]; tributylhexadecylphosphonium bromide inhibits the reaction [Fructose results in increased expression of IL1B protein]		 CTD PMID:15885234 PMID:22426011 PMID:24491314 PMID:25679220 PMID:25813056 PMID:26358169 PMID:26858005 PMID:31005848 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726 		JBrowse link
G Il2 interleukin 2 increases expression EXP Fructose results in increased expression of IL2 protein CTD PMID:15885234 NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854 		JBrowse link
G Il6 interleukin 6 multiple interactions
increases expression		 EXP
ISO		 [gadolinium chloride co-treated with Fructose co-treated with Copper deficiency] results in decreased expression of IL6 mRNA; Allopurinol inhibits the reaction [Fructose results in increased expression of IL6 protein]; galangin inhibits the reaction [Fructose results in increased expression of IL6 protein]; Genistein inhibits the reaction [Fructose results in increased expression of IL6 protein]; geraniol inhibits the reaction [Fructose results in increased expression of IL6 protein]; Metformin inhibits the reaction [Fructose results in increased expression of IL6 protein]; PTMA protein inhibits the reaction [Fructose results in increased expression of IL6 protein]; Quercetin inhibits the reaction [Fructose results in increased expression of IL6 protein]; Resveratrol inhibits the reaction [Fructose results in increased expression of IL6 protein]; Rutin inhibits the reaction [Fructose results in increased expression of IL6 protein]; tributylhexadecylphosphonium bromide inhibits the reaction [Fructose results in increased expression of IL6 protein] CTD PMID:15885234 PMID:21704028 PMID:21708140 PMID:22426011 PMID:25108154 PMID:25813056 PMID:26358169 PMID:27531227 PMID:31005848 PMID:31672515 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807 		JBrowse link
G Ins2 insulin 2 decreases response to substance
increases secretion
increases expression
multiple interactions		 ISO
EXP		 Fructose results in decreased susceptibility to INS protein
Fructose results in increased secretion of INS protein
Fructose results in increased expression of INS protein; Fructose results in increased expression of INS2 mRNA
Curcumin inhibits the reaction [Fructose results in increased expression of INS protein]; Hemin inhibits the reaction [Fructose results in increased expression of INS protein]; INS protein inhibits the reaction [Fructose results in increased expression of AGTR1A mRNA]; Quercetin inhibits the reaction [Fructose results in increased expression of INS2 mRNA]		 CTD PMID:12010179 PMID:18360027 PMID:23533474 PMID:25268984 PMID:26713546 NCBI chr 1:215,856,967...215,858,034
Ensembl chr 1:215,856,971...215,858,034 		JBrowse link
G Insig1 insulin induced gene 1 decreases expression
increases expression
multiple interactions		 ISO Fructose results in decreased expression of INSIG1 protein
Fructose results in increased expression of INSIG1 mRNA
Phenylbutyrates inhibits the reaction [Fructose results in decreased expression of INSIG1 protein]		 CTD PMID:22698815 NCBI chr 4:342,302...350,515
Ensembl chr 4:342,302...350,515 		JBrowse link
G Insig2 insulin induced gene 2 increases expression ISO Fructose results in increased expression of INSIG2 mRNA CTD PMID:22698815 NCBI chr13:37,264,818...37,292,718
Ensembl chr13:37,266,312...37,287,458 		JBrowse link
G Insr insulin receptor decreases expression
decreases phosphorylation
multiple interactions		 EXP Fructose results in decreased expression of INSR mRNA; Fructose results in decreased expression of INSR protein
Fructose results in decreased phosphorylation of INSR protein
[Fructose co-treated with Oleanolic Acid] results in increased expression of INSR mRNA; [Fructose co-treated with Sodium Chloride, Dietary deficiency] results in decreased expression of INSR mRNA; [Fructose co-treated with Sodium Chloride, Dietary deficiency] results in decreased expression of INSR protein; Allopurinol inhibits the reaction [Fructose results in decreased phosphorylation of INSR protein]; Quercetin inhibits the reaction [Fructose results in decreased phosphorylation of INSR protein]; Rutin inhibits the reaction [Fructose results in decreased phosphorylation of INSR protein]		 CTD PMID:14573337 PMID:14633139 PMID:22426011 PMID:24491314 PMID:24704288 NCBI chr12:1,682,527...1,816,414
Ensembl chr12:1,680,957...1,816,414 		JBrowse link
G Irf3 interferon regulatory factor 3 multiple interactions ISO [Fructose co-treated with Ethanol] results in increased expression of IRF3 protein; Fructose promotes the reaction [Ethanol results in increased expression of IRF3 mRNA] CTD PMID:26858005 NCBI chr 1:100,992,244...100,997,202
Ensembl chr 1:100,992,405...100,997,198 		JBrowse link
G Irf7 interferon regulatory factor 7 multiple interactions
increases expression		 ISO [Fructose co-treated with Ethanol] results in increased expression of IRF7 protein
Fructose results in increased expression of IRF7 protein		 CTD PMID:26858005 NCBI chr 1:214,249,388...214,252,909
Ensembl chr 1:214,248,837...214,252,456 		JBrowse link
G Irs1 insulin receptor substrate 1 decreases expression
increases phosphorylation
decreases phosphorylation
multiple interactions
affects phosphorylation		 EXP
ISO		 Fructose results in decreased expression of IRS1 mRNA; Fructose results in decreased expression of IRS1 protein
Fructose results in increased phosphorylation of IRS1 protein
Fructose results in decreased phosphorylation of IRS1 protein
[Fructose co-treated with Oleanolic Acid] results in increased expression of IRS1 mRNA; [Fructose co-treated with Oleanolic Acid] results in increased expression of IRS1 protein; [Fructose co-treated with resveratrol] results in increased expression of IRS1 mRNA; Allopurinol inhibits the reaction [Fructose results in decreased phosphorylation of IRS1 protein]; Curcumin inhibits the reaction [Fructose affects the phosphorylation of IRS1 protein]; NOS3 protein inhibits the reaction [Fructose results in decreased expression of IRS1 protein]; Oleanolic Acid inhibits the reaction [Fructose results in increased phosphorylation of IRS1 protein]; Quercetin inhibits the reaction [Fructose results in decreased phosphorylation of IRS1 protein]; Rutin inhibits the reaction [Fructose results in decreased phosphorylation of IRS1 protein]		 CTD PMID:19008412 PMID:19165636 PMID:22426011 PMID:24704288 PMID:26488877 PMID:26713546 PMID:31672515 NCBI chr 9:88,033,668...88,086,488
Ensembl chr 9:88,033,668...88,086,488 		JBrowse link
G Irs2 insulin receptor substrate 2 decreases expression
multiple interactions		 EXP Fructose results in decreased expression of IRS2 mRNA; Fructose results in decreased expression of IRS2 protein
NOS3 protein inhibits the reaction [Fructose results in decreased expression of IRS2 protein]; resveratrol inhibits the reaction [Fructose results in decreased expression of IRS2 mRNA]		 CTD PMID:19008412 PMID:19165636 PMID:26488877 NCBI chr16:83,824,515...83,848,569
Ensembl chr16:83,824,430...83,848,684 		JBrowse link
G Itgb1 integrin subunit beta 1 decreases expression ISO Fructose results in decreased expression of ITGB1 mRNA CTD PMID:31655124 NCBI chr19:61,677,512...61,725,537
Ensembl chr19:61,677,542...61,725,535 		JBrowse link
G Itih3 inter-alpha trypsin inhibitor, heavy chain 3 decreases expression EXP Fructose results in decreased expression of ITIH3 protein CTD PMID:26930160 NCBI chr16:6,983,779...7,007,288
Ensembl chr16:6,992,062...7,007,287 		JBrowse link
G Jak2 Janus kinase 2 decreases phosphorylation
multiple interactions		 EXP Fructose results in decreased phosphorylation of JAK2 protein
Quercetin inhibits the reaction [Fructose results in decreased phosphorylation of JAK2 protein]; Rutin inhibits the reaction [Fructose results in decreased phosphorylation of JAK2 protein]		 CTD PMID:22426011 NCBI chr 1:247,398,667...247,457,521
Ensembl chr 1:247,398,598...247,458,509 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression		 EXP Dactinomycin inhibits the reaction [Fructose results in increased expression of JUN mRNA] CTD PMID:11123204 PMID:11557636 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277 		JBrowse link
G Jup junction plakoglobin multiple interactions EXP [Fructose co-treated with bisphenol A] results in increased expression of JUP protein CTD PMID:26930160 NCBI chr10:88,280,517...88,307,451
Ensembl chr10:88,279,632...88,307,412 		JBrowse link
G Kdr kinase insert domain receptor multiple interactions EXP [bisphenol A co-treated with Fructose] results in increased expression of KDR mRNA CTD PMID:27622962 NCBI chr14:34,727,677...34,787,127
Ensembl chr14:34,727,623...34,787,183 		JBrowse link
G Khk ketohexokinase multiple interactions
increases expression		 ISO
EXP		 KHK protein promotes the reaction [Fructose results in decreased abundance of Adenosine Triphosphate]; KHK protein promotes the reaction [Fructose results in increased abundance of Reactive Oxygen Species]; KHK protein promotes the reaction [Fructose results in increased secretion of CCL2 protein]
Atorvastatin inhibits the reaction [Fructose results in increased expression of KHK protein]
Fructose results in increased expression of KHK mRNA; Fructose results in increased expression of KHK protein
FGF21 gene mutant form inhibits the reaction [Fructose results in increased expression of KHK mRNA]; Fructose results in increased expression of and results in increased activity of KHK protein		 CTD PMID:15066988 PMID:18346472 PMID:18395287 PMID:19158351 PMID:21122807 PMID:26858005 PMID:28123933 NCBI chr 6:26,810,577...26,821,013
Ensembl chr 6:26,810,579...26,820,959 		JBrowse link
G Klk1 kallikrein 1 multiple interactions EXP KLK1 protein inhibits the reaction [Fructose results in increased expression of AGTR1B mRNA]; KLK1 protein inhibits the reaction [Fructose results in increased expression of EDN1 mRNA]; KLK1 protein inhibits the reaction [Fructose results in increased expression of EDNRA mRNA] CTD PMID:14568997 NCBI chr 1:100,131,562...100,135,556
Ensembl chr 1:100,059,967...100,203,329
Ensembl chr 1:100,059,967...100,203,329
Ensembl chr 1:100,059,967...100,203,329 		JBrowse link
G Kng2 kininogen 2 decreases expression EXP Fructose results in decreased expression of MAP1 protein CTD PMID:26930160 NCBI chr11:81,509,185...81,516,759 JBrowse link
G Krt18 keratin 18 increases expression EXP Fructose increases expression of Krt18 protein in liver and serum RGD PMID:29989845 RGD:26884460 NCBI chr 7:143,629,455...143,633,131
Ensembl chr 7:143,629,455...143,633,131 		JBrowse link
G Lcn2 lipocalin 2 multiple interactions EXP 2-(3-(4-ethoxybenzyl)-4-chlorophenyl)-6-hydroxymethyltetrahydro-2H-pyran-3,4,5-triol inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of LCN2 protein]; 2-(3-(4-ethoxybenzyl)-4-chlorophenyl)-6-hydroxymethyltetrahydro-2H-pyran-3,4,5-triol inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of LCN2 protein]; [2-(3-(4-ethoxybenzyl)-4-chlorophenyl)-6-hydroxymethyltetrahydro-2H-pyran-3,4,5-triol co-treated with Atorvastatin] inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of LCN2 protein]; [Fructose co-treated with Dietary Fats] results in increased expression of LCN2 protein; [Streptozocin co-treated with Fructose] results in increased expression of LCN2 protein; Atorvastatin inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of LCN2 protein]; Metformin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of LCN2 protein] CTD PMID:30551545 PMID:32259528 NCBI chr 3:11,414,189...11,417,534
Ensembl chr 3:11,414,186...11,417,546 		JBrowse link
G Lct lactase increases expression EXP Fructose results in increased expression of LCT mRNA CTD PMID:11242478 NCBI chr13:44,998,414...45,040,593
Ensembl chr13:44,998,414...45,040,593 		JBrowse link
G Ldhb lactate dehydrogenase B multiple interactions EXP [Fructose co-treated with bisphenol A] results in decreased expression of LDHB protein CTD PMID:26930160 NCBI chr 4:176,701,980...176,719,999
Ensembl chr 4:176,701,983...176,720,012 		JBrowse link
G Lep leptin increases secretion
increases expression
multiple interactions		 EXP Fructose results in increased secretion of LEP protein
Fructose results in increased expression of LEP mRNA; Fructose results in increased expression of LEP protein
[Fenofibrate co-treated with Resveratrol] inhibits the reaction [Fructose results in increased expression of LEP mRNA]; [Ozone co-treated with Fructose] results in increased expression of LEP mRNA; [Particulate Matter co-treated with Fructose] results in increased expression of LEP mRNA; [Particulate Matter co-treated with Ozone co-treated with Fructose] results in increased expression of LEP mRNA; Allopurinol inhibits the reaction [Fructose results in increased expression of LEP protein]; Atorvastatin affects the reaction [Fructose results in increased expression of LEP protein]; Fenofibrate inhibits the reaction [Fructose results in increased expression of LEP mRNA]; Quercetin inhibits the reaction [Fructose results in increased expression of LEP protein]; Quercetin inhibits the reaction [Fructose results in increased secretion of LEP protein]; Resveratrol inhibits the reaction [Fructose results in increased expression of LEP mRNA]; Rutin inhibits the reaction [Fructose results in increased expression of LEP protein]		 CTD PMID:10780946 PMID:11741341 PMID:18627777 PMID:19165636 PMID:21122807 PMID:22426011 PMID:23016136 PMID:23533474 PMID:23968387 PMID:26973390 NCBI chr 4:56,337,695...56,351,818
Ensembl chr 4:56,337,695...56,351,818 		JBrowse link
G Lepr leptin receptor multiple interactions EXP Allopurinol inhibits the reaction [Fructose results in increased expression of and results in increased phosphorylation of LEPR protein]; Fructose results in increased expression of and results in increased phosphorylation of LEPR protein; Quercetin inhibits the reaction [Fructose results in increased expression of and results in increased phosphorylation of LEPR protein]; Rutin inhibits the reaction [Fructose results in increased expression of and results in increased phosphorylation of LEPR protein] CTD PMID:22426011 NCBI chr 5:120,503,475...120,682,281
Ensembl chr 5:120,564,645...120,682,221 		JBrowse link
G Lgals9 galectin 9 multiple interactions
decreases expression		 EXP Allopurinol inhibits the reaction [Fructose results in decreased expression of LGALS9 mRNA]; Allopurinol inhibits the reaction [Fructose results in decreased expression of LGALS9 protein]; Quercetin inhibits the reaction [Fructose results in decreased expression of LGALS9 mRNA]; Quercetin inhibits the reaction [Fructose results in decreased expression of LGALS9 protein]; Rutin inhibits the reaction [Fructose results in decreased expression of LGALS9 mRNA]; Rutin inhibits the reaction [Fructose results in decreased expression of LGALS9 protein]
Fructose results in decreased expression of LGALS9 mRNA; Fructose results in decreased expression of LGALS9 protein		 CTD PMID:19605544 NCBI chr10:64,737,022...64,760,195
Ensembl chr10:64,737,022...64,760,201 		JBrowse link
G Maoa monoamine oxidase A multiple interactions EXP [Fructose co-treated with bisphenol A] results in increased expression of MAOA protein CTD PMID:26930160 NCBI chr  X:6,554,698...6,620,722
Ensembl chr  X:6,554,698...6,620,722 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation
decreases phosphorylation
multiple interactions		 EXP Fructose results in increased phosphorylation of MAPK1 protein
Fructose results in decreased phosphorylation of MAPK1 protein
Curcumin inhibits the reaction [Fructose results in increased phosphorylation of MAPK1 protein]; Quercetin inhibits the reaction [Fructose results in decreased phosphorylation of MAPK1 protein]; Rutin inhibits the reaction [Fructose results in decreased phosphorylation of MAPK1 protein]		 CTD PMID:22426011 PMID:26713546 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation
decreases phosphorylation
multiple interactions		 EXP Fructose results in increased phosphorylation of MAPK3 protein
Fructose results in decreased phosphorylation of MAPK3 protein
Curcumin inhibits the reaction [Fructose results in increased phosphorylation of MAPK3 protein]; Quercetin inhibits the reaction [Fructose results in decreased phosphorylation of MAPK3 protein]; Rutin inhibits the reaction [Fructose results in decreased phosphorylation of MAPK3 protein]		 CTD PMID:22426011 PMID:26713546 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions
increases expression		 EXP imoxin inhibits the reaction [Fructose results in increased expression of MAPK8 protein] CTD PMID:29430716 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347 		JBrowse link
G Mir33 microRNA 33 multiple interactions EXP [Fructose co-treated with Streptozocin] results in increased expression of MIR33A mRNA; Ghrelin inhibits the reaction [[Fructose co-treated with Streptozocin] results in increased expression of MIR33A mRNA] CTD PMID:31468622 NCBI chr 7:123,431,612...123,431,680
Ensembl chr 7:123,431,612...123,431,680 		JBrowse link
G Mlx MAX dimerization protein MLX increases expression EXP Fructose results in increased expression of MLX mRNA CTD PMID:18346472 NCBI chr10:88,997,011...89,002,154
Ensembl chr10:88,997,399...89,002,152 		JBrowse link
G Mlxipl MLX interacting protein-like multiple interactions
decreases expression
increases expression
increases activity		 EXP
ISO		 Atorvastatin inhibits the reaction [Fructose affects the localization of and results in increased activity of MLXIPL protein]; Atorvastatin inhibits the reaction [Fructose results in increased expression of MLXIPL protein]; Fructose affects the localization of and results in increased activity of MLXIPL protein; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Atorvastatin inhibits the reaction [Fructose results in increased activity of MLXIPL protein]]
Fructose results in decreased expression of MLXIPL mRNA
Fructose results in increased expression of MLXIPL mRNA alternative form
FGF21 gene mutant form inhibits the reaction [Fructose results in increased expression of MLXIPL mRNA alternative form]; MLXIPL gene mutant form inhibits the reaction [Fructose results in increased expression of FGF21 mRNA]; MLXIPL gene mutant form inhibits the reaction [Fructose results in increased secretion of FGF21 protein]
Fructose results in increased expression of MLXIPL mRNA; Fructose results in increased expression of MLXIPL protein		 CTD PMID:18346472 PMID:19053045 PMID:19799862 PMID:21122807 PMID:28123933 NCBI chr12:24,590,645...24,619,639 JBrowse link
G Mlycd malonyl-CoA decarboxylase multiple interactions
decreases expression		 EXP [Fenofibrate co-treated with resveratrol] inhibits the reaction [Fructose results in decreased expression of MLYCD mRNA]; Fenofibrate inhibits the reaction [Fructose results in decreased expression of MLYCD mRNA]; resveratrol inhibits the reaction [Fructose results in decreased expression of MLYCD mRNA] CTD PMID:26973390 NCBI chr19:52,032,950...52,048,773
Ensembl chr19:52,032,886...52,048,753 		JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions ISO [FGF21 gene mutant form results in increased susceptibility to Fructose] which results in increased expression of MMP2 mRNA CTD PMID:28123933 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611 		JBrowse link
G Mmp9 matrix metallopeptidase 9 increases expression ISO Fructose results in increased expression of MMP9 mRNA CTD PMID:31655124 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520 		JBrowse link
G Mpst mercaptopyruvate sulfurtransferase multiple interactions EXP [Fructose co-treated with bisphenol A] results in decreased expression of MPST protein CTD PMID:26930160 NCBI chr 7:119,626,636...119,631,317
Ensembl chr 7:119,626,637...119,631,425 		JBrowse link
G Msn moesin multiple interactions EXP [Fructose co-treated with bisphenol A] results in increased expression of MSN protein CTD PMID:26930160 NCBI chr  X:65,226,834...65,294,192
Ensembl chr  X:65,226,748...65,295,810 		JBrowse link
G Mt-atp6 mitochondrially encoded ATP synthase membrane subunit 6 increases expression EXP Fructose results in increased expression of ATP6 protein CTD PMID:11934685 NCBI chr MT:7,919...8,599
Ensembl chr MT:7,919...8,599 		JBrowse link
G Mt-co2 mitochondrially encoded cytochrome c oxidase II multiple interactions EXP [Fructose co-treated with bisphenol A] results in decreased expression of COX2 protein CTD PMID:26930160 NCBI chr MT:7,006...7,689
Ensembl chr MT:7,006...7,689 		JBrowse link
G Mt1-ps2 metallothionein 1, pseudogene 2 multiple interactions
increases expression		 EXP Atorvastatin inhibits the reaction [Fructose results in increased expression of MT1-PS2 mRNA] CTD PMID:21122807
G Mt2A metallothionein 2A increases expression
multiple interactions		 EXP Fructose results in increased expression of MT2A mRNA
Atorvastatin inhibits the reaction [Fructose results in increased expression of MT2A mRNA]		 CTD PMID:21122807 NCBI chr19:11,307,966...11,308,740
Ensembl chr19:11,307,967...11,308,740 		JBrowse link
G Mttp microsomal triglyceride transfer protein multiple interactions
increases expression		 EXP
ISO		 [Fructose co-treated with Copper deficiency] results in decreased expression of MTTP mRNA
FGF21 gene mutant form inhibits the reaction [Fructose results in increased expression of MTTP mRNA]		 CTD PMID:25813056 PMID:28123933 NCBI chr 2:243,366,181...243,407,608
Ensembl chr 2:243,366,181...243,407,608 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor decreases expression ISO Fructose results in decreased expression of MYC mRNA CTD PMID:2558650 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240 		JBrowse link
G Myd88 MYD88, innate immune signal transduction adaptor multiple interactions ISO Fructose promotes the reaction [Ethanol results in increased expression of MYD88 mRNA] CTD PMID:26858005 NCBI chr 8:128,022,512...128,027,462
Ensembl chr 8:128,022,473...128,026,841 		JBrowse link
G Myh6 myosin heavy chain 6 increases expression
multiple interactions		 ISO Fructose results in increased expression of MYH6 mRNA
SIRT1 protein affects the reaction [Fructose results in increased expression of MYH6 mRNA]		 CTD PMID:18192211 NCBI chr15:33,605,653...33,629,730
Ensembl chr15:33,605,654...33,629,699 		JBrowse link
G Myh9 myosin, heavy chain 9 decreases expression
multiple interactions		 EXP Fructose results in decreased expression of MYH9 protein
[Fructose co-treated with bisphenol A] results in increased expression of MYH9 protein		 CTD PMID:26930160 NCBI chr 7:118,740,005...118,792,507
Ensembl chr 7:118,741,110...118,792,625 		JBrowse link
G Ndufa5 NADH:ubiquinone oxidoreductase subunit A5 multiple interactions EXP [Fructose co-treated with bisphenol A] results in increased expression of NDUFA5 protein CTD PMID:26930160 NCBI chr 4:51,590,413...51,598,771
Ensembl chr 4:51,590,413...51,598,771 		JBrowse link
G Ndufa9 NADH:ubiquinone oxidoreductase subunit A9 multiple interactions EXP [Fructose co-treated with bisphenol A] results in decreased expression of NDUFA9 protein CTD PMID:26930160 NCBI chr 4:159,371,263...159,399,636
Ensembl chr 4:159,371,259...159,399,634 		JBrowse link
G Nfatc4 nuclear factor of activated T-cells 4 increases expression
multiple interactions		 EXP Fructose results in increased expression of NFATC4 protein
tributylhexadecylphosphonium bromide inhibits the reaction [Fructose results in increased expression of NFATC4 protein]		 CTD PMID:26358169 NCBI chr15:34,493,163...34,502,238
Ensembl chr15:34,493,138...34,504,326 		JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 increases expression
multiple interactions		 ISO
EXP		 Fructose results in increased expression of NFE2L2 protein
2-(3-(4-ethoxybenzyl)-4-chlorophenyl)-6-hydroxymethyltetrahydro-2H-pyran-3,4,5-triol inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of NFE2L2 protein]; [Atorvastatin co-treated with 2-(3-(4-ethoxybenzyl)-4-chlorophenyl)-6-hydroxymethyltetrahydro-2H-pyran-3,4,5-triol] inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of NFE2L2 protein]; [Fructose co-treated with Dietary Fats] results in increased expression of NFE2L2 protein; Atorvastatin inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of NFE2L2 protein]
Fructose promotes the reaction [PPARD gene mutant form results in increased phosphorylation of NFE2L2 protein]; Plant Preparations inhibits the reaction [Fructose results in increased expression of NFE2L2 protein]		 CTD PMID:27531227 PMID:29289645 PMID:32259528 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996 		JBrowse link
G Nfkbia NFKB inhibitor alpha increases degradation
increases phosphorylation
multiple interactions		 EXP Fructose results in increased degradation of NFKBIA protein
Fructose results in increased phosphorylation of NFKBIA protein
Allopurinol inhibits the reaction [Fructose results in increased phosphorylation of NFKBIA protein]; Curcumin inhibits the reaction [Fructose results in increased degradation of NFKBIA protein]; Quercetin inhibits the reaction [Fructose results in increased phosphorylation of NFKBIA protein]		 CTD PMID:24491314 PMID:26713546 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457 		JBrowse link
G Ngf nerve growth factor decreases expression EXP Fructose results in decreased expression of NGF mRNA; Fructose results in decreased expression of NGF protein CTD PMID:18585860 NCBI chr 2:204,886,158...204,939,523
Ensembl chr 2:204,886,202...204,940,453 		JBrowse link
G Ngfr nerve growth factor receptor decreases expression EXP Fructose results in decreased expression of NGFR mRNA CTD PMID:18585860 NCBI chr10:83,389,828...83,408,061
Ensembl chr10:83,389,847...83,408,061 		JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 increases expression
multiple interactions		 EXP Fructose results in increased expression of NLRP3 protein
Allopurinol inhibits the reaction [Fructose results in increased expression of NLRP3 protein]; Quercetin inhibits the reaction [Fructose results in increased expression of NLRP3 protein]; Rutin inhibits the reaction [Fructose results in increased expression of NLRP3 protein]		 CTD PMID:22426011 PMID:24491314 NCBI chr10:45,884,324...45,918,290
Ensembl chr10:45,893,018...45,918,254 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
increases expression		 EXP
ISO		 2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [caryophyllene inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of NOS2 protein]]; [Dietary Fats co-treated with Fructose] results in increased expression of NOS2 protein; [Fructose results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide; caryophyllene inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of NOS2 protein]; iodopravadoline inhibits the reaction [caryophyllene inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of NOS2 protein]]; Pioglitazone inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of NOS2 protein]; Resveratrol inhibits the reaction [Fructose results in increased expression of NOS2 mRNA]; Resveratrol inhibits the reaction [Fructose results in increased expression of NOS2 protein]
Fructose results in increased expression of NOS2 mRNA; Fructose results in increased expression of NOS2 protein		 CTD PMID:10090849 PMID:26488877 PMID:28257781 PMID:30343038 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190 		JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions
decreases expression
decreases phosphorylation
decreases activity		 EXP
ISO		 2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [caryophyllene inhibits the reaction [[Dietary Fats co-treated with Fructose] results in decreased expression of NOS3 protein]]; [bisphenol A co-treated with Fructose] results in increased expression of NOS3 mRNA; [Dietary Fats co-treated with Fructose] results in decreased expression of NOS3 protein; [Resveratrol co-treated with Fructose] results in increased expression of NOS3 mRNA; caryophyllene inhibits the reaction [[Dietary Fats co-treated with Fructose] results in decreased expression of NOS3 protein]; Fish Oils inhibits the reaction [Fructose results in decreased expression of NOS3 mRNA]; Fish Oils inhibits the reaction [Fructose results in decreased expression of NOS3 protein]; iodopravadoline inhibits the reaction [caryophyllene inhibits the reaction [[Dietary Fats co-treated with Fructose] results in decreased expression of NOS3 protein]]; Metformin inhibits the reaction [Fructose results in decreased phosphorylation of NOS3 protein]; NOS3 protein inhibits the reaction [Fructose results in decreased expression of IRS1 protein]; NOS3 protein inhibits the reaction [Fructose results in decreased expression of IRS2 protein]; NOS3 protein inhibits the reaction [Fructose results in decreased phosphorylation of AKT1 protein]; Pioglitazone inhibits the reaction [[Dietary Fats co-treated with Fructose] results in decreased expression of NOS3 protein]; Resveratrol inhibits the reaction [Fructose results in decreased expression of NOS3 mRNA]; Resveratrol inhibits the reaction [Fructose results in decreased expression of NOS3 protein]; Resveratrol inhibits the reaction [Fructose results in decreased phosphorylation of NOS3 protein]
Fructose results in decreased expression of NOS3 mRNA; Fructose results in decreased expression of NOS3 protein
Fructose results in decreased activity of NOS3 protein		 CTD PMID:10580434 PMID:15752949 PMID:18508964 PMID:19008412 PMID:25108154 PMID:26488877 PMID:27622962 PMID:30343038 NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410 		JBrowse link
G Nox4 NADPH oxidase 4 increases expression EXP Fructose results in increased expression of NOX4 mRNA CTD PMID:17587757 NCBI chr 1:150,796,359...150,976,186
Ensembl chr 1:150,797,084...150,976,194 		JBrowse link
G Nphs1 NPHS1 adhesion molecule, nephrin multiple interactions EXP 2-(3-(4-ethoxybenzyl)-4-chlorophenyl)-6-hydroxymethyltetrahydro-2H-pyran-3,4,5-triol inhibits the reaction [[Streptozocin co-treated with Fructose] results in decreased expression of NPHS1 mRNA]; [Streptozocin co-treated with Fructose] results in decreased expression of NPHS1 mRNA; Metformin inhibits the reaction [[Streptozocin co-treated with Fructose] results in decreased expression of NPHS1 mRNA] CTD PMID:30551545 NCBI chr 1:88,922,346...88,950,560
Ensembl chr 1:88,922,433...88,950,559 		JBrowse link
G Npy neuropeptide Y decreases expression EXP Fructose results in decreased expression of NPY mRNA CTD PMID:18627777 NCBI chr 4:79,557,856...79,565,059
Ensembl chr 4:79,557,854...79,565,097
Ensembl chr 4:79,557,854...79,565,097 		JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 multiple interactions ISO NR0B2 protein inhibits the reaction [AHR protein results in increased susceptibility to [Dietary Fats co-treated with Fructose]]; NR0B2 protein results in decreased susceptibility to [Dietary Fats co-treated with Fructose] CTD PMID:29416063 NCBI chr 5:151,776,004...151,779,319
Ensembl chr 5:151,776,004...151,779,319 		JBrowse link
G Nr2f1 nuclear receptor subfamily 2, group F, member 1 multiple interactions ISO Fructose affects the reaction [NR2F1 protein binds to SHBG promoter] CTD PMID:17992261 NCBI chr 2:5,569,954...5,579,894
Ensembl chr 2:5,569,935...5,579,894 		JBrowse link
G Oat ornithine aminotransferase multiple interactions EXP Fructose inhibits the reaction [Cyclic AMP results in increased activity of OAT protein]; Fructose inhibits the reaction [Cyclic AMP results in increased expression of OAT mRNA] CTD PMID:2827574 NCBI chr 1:204,562,289...204,582,070
Ensembl chr 1:204,562,289...204,582,070 		JBrowse link
G Oga O-GlcNAcase multiple interactions EXP 2-(3-(4-ethoxybenzyl)-4-chlorophenyl)-6-hydroxymethyltetrahydro-2H-pyran-3,4,5-triol inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of and results in increased secretion of OGA protein]; [Streptozocin co-treated with Fructose] results in increased expression of and results in increased secretion of OGA protein; Metformin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of and results in increased secretion of OGA protein] CTD PMID:30551545 NCBI chr 1:265,506,752...265,542,452
Ensembl chr 1:265,507,451...265,542,276 		JBrowse link
G Paip2 poly(A) binding protein interacting protein 2 multiple interactions ISO Fructose promotes the reaction [PAIP2 protein binds to SLC2A5 3' UTR] CTD PMID:12820898 NCBI chr18:28,397,320...28,415,911
Ensembl chr18:28,409,955...28,415,910 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases expression ISO Fructose results in increased expression of PARP1 protein CTD PMID:28257781 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716 		JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1 multiple interactions
increases expression
increases activity		 EXP Rosiglitazone inhibits the reaction [Fructose results in increased expression of PCK1 mRNA]; Rosiglitazone inhibits the reaction [Fructose results in increased expression of PCK1 protein]
Fructose results in increased expression of PCK1 mRNA; Fructose results in increased expression of PCK1 protein
Fructose results in increased activity of PCK1 protein		 CTD PMID:19196556 PMID:21212096 NCBI chr 3:171,213,936...171,219,885
Ensembl chr 3:171,213,936...171,219,871 		JBrowse link
G Pcmt1 protein-L-isoaspartate (D-aspartate) O-methyltransferase 1 multiple interactions EXP [Fructose co-treated with bisphenol A] results in increased expression of PCMT1 protein CTD PMID:26930160 NCBI chr 1:1,734,863...1,767,759
Ensembl chr 1:1,736,276...1,767,618 		JBrowse link
G Pdk1 pyruvate dehydrogenase kinase 1 multiple interactions EXP [Fructose co-treated with bisphenol A] results in increased expression of PDK1 protein CTD PMID:26930160 NCBI chr 3:58,530,870...58,561,494
Ensembl chr 3:58,530,870...58,558,027 		JBrowse link
G Pdx1 pancreatic and duodenal homeobox 1 multiple interactions
increases expression		 EXP Quercetin inhibits the reaction [Fructose results in increased expression of PDX1 protein]
Fructose results in increased expression of PDX1 mRNA; Fructose results in increased expression of PDX1 protein		 CTD PMID:23533474 NCBI chr12:9,496,044...9,501,211
Ensembl chr12:9,496,044...9,501,213 		JBrowse link
G Pemt phosphatidylethanolamine N-methyltransferase multiple interactions ISO [Dietary Fats co-treated with Fructose] results in increased expression of PEMT mRNA; PEMT protein promotes the reaction [AHR protein results in increased susceptibility to [Dietary Fats co-treated with Fructose]] CTD PMID:29416063 NCBI chr10:46,339,821...46,404,640
Ensembl chr10:46,339,821...46,404,642 		JBrowse link
G Pf4 platelet factor 4 increases expression ISO Fructose results in increased expression of PF4 mRNA CTD PMID:31655124 NCBI chr14:18,848,549...18,849,258
Ensembl chr14:18,848,549...18,849,258 		JBrowse link
G Pfkl phosphofructokinase, liver type increases expression EXP Fructose results in increased expression of PFKL mRNA CTD PMID:18346472 NCBI chr20:11,393,860...11,415,889
Ensembl chr20:11,393,877...11,415,882 		JBrowse link
G Phb2 prohibitin 2 multiple interactions EXP [Fructose co-treated with bisphenol A] results in decreased expression of PHB2 protein CTD PMID:26930160 NCBI chr 4:157,230,769...157,235,375
Ensembl chr 4:157,230,769...157,235,367 		JBrowse link
G Pik3c2g phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma multiple interactions EXP [Fructose co-treated with Oleanolic Acid] results in increased expression of PIK3C2G mRNA CTD PMID:24704288 NCBI chr 4:173,732,196...174,102,502
Ensembl chr 4:173,732,248...174,102,496 		JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 multiple interactions EXP [Fructose co-treated with Dietary Fats] results in decreased expression of PIK3R1 protein CTD PMID:32259528 NCBI chr 2:31,742,326...31,826,882
Ensembl chr 2:31,745,088...31,826,867 		JBrowse link
G Pklr pyruvate kinase L/R increases expression
multiple interactions
affects expression
affects degradation		 ISO
EXP		 Fructose results in increased expression of PKLR mRNA
Atorvastatin inhibits the reaction [Fructose results in increased expression of PKLR mRNA]; GCG protein affects the reaction [Fructose affects the degradation of PKLR mRNA]
Fructose affects the expression of PKLR mRNA
FGF21 gene mutant form inhibits the reaction [Fructose results in increased expression of PKLR mRNA]; lactisole inhibits the reaction [Fructose results in increased expression of PKLR mRNA]		 CTD PMID:2193023 PMID:2414297 PMID:2824512 PMID:6526814 PMID:6759123 PMID:17786952 PMID:18346472 PMID:19053045 PMID:21122807 PMID:28123933 NCBI chr 2:188,449,158...188,458,034
Ensembl chr 2:188,449,210...188,459,592 		JBrowse link
G Pkm pyruvate kinase M1/2 multiple interactions EXP [Fructose co-treated with bisphenol A] results in decreased expression of PKM protein CTD PMID:26930160 NCBI chr 8:64,480,963...64,502,957
Ensembl chr 8:64,481,172...64,502,722 		JBrowse link
G Plat plasminogen activator, tissue type increases expression ISO Fructose results in increased expression of PLAT mRNA CTD PMID:31655124 NCBI chr16:74,098,263...74,122,897
Ensembl chr16:74,098,260...74,122,889 		JBrowse link
G Pnpla2 patatin-like phospholipase domain containing 2 increases expression ISO Fructose results in increased expression of PNPLA2 protein CTD PMID:28257781 NCBI chr 1:214,434,638...214,439,720
Ensembl chr 1:214,434,626...214,439,720
Ensembl chr 1:214,434,626...214,439,720 		JBrowse link
G Pomc proopiomelanocortin decreases expression EXP Fructose results in decreased expression of POMC mRNA CTD PMID:18627777 NCBI chr 6:28,382,937...28,388,771
Ensembl chr 6:28,382,962...28,388,967 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha increases expression
multiple interactions
decreases expression		 EXP
ISO		 Fructose results in increased expression of PPARA protein
[Plant Preparations co-treated with Fructose] results in increased expression of PPARA protein
Fructose results in decreased expression of PPARA protein
[2-(3-(4-ethoxybenzyl)-4-chlorophenyl)-6-hydroxymethyltetrahydro-2H-pyran-3,4,5-triol co-treated with Atorvastatin] inhibits the reaction [[Fructose co-treated with Dietary Fats] results in decreased expression of PPARA protein]; [Fructose co-treated with Dietary Fats] results in decreased expression of PPARA protein; Allopurinol inhibits the reaction [Fructose results in decreased expression of PPARA protein]; Atorvastatin inhibits the reaction [Fructose results in increased expression of PPARA protein]; Fenofibrate inhibits the reaction [Fructose results in decreased expression of and results in decreased activity of PPARA protein]; Fructose results in decreased expression of and results in decreased activity of PPARA protein; Quercetin inhibits the reaction [Fructose results in decreased expression of PPARA protein]; Rutin inhibits the reaction [Fructose results in decreased expression of PPARA protein]		 CTD PMID:11934685 PMID:12065722 PMID:22426011 PMID:27531227 PMID:28257781 PMID:32259528 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752 		JBrowse link
G Ppard peroxisome proliferator-activated receptor delta multiple interactions
decreases response to substance		 ISO [PPARD mRNA results in decreased susceptibility to Fructose] which results in decreased expression of VLDLR mRNA; Fructose inhibits the reaction [PPARD mRNA results in decreased expression of VLDLR mRNA]; Fructose promotes the reaction [PPARD gene mutant form results in increased expression of VLDLR mRNA]; Fructose promotes the reaction [PPARD gene mutant form results in increased expression of VLDLR protein]; Fructose promotes the reaction [PPARD gene mutant form results in increased phosphorylation of NFE2L2 protein] CTD PMID:29289645 NCBI chr20:7,818,289...7,883,482
Ensembl chr20:7,818,289...7,885,333 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma increases expression
decreases activity
multiple interactions		 EXP Fructose results in increased expression of PPARG mRNA
Fructose results in decreased activity of PPARG protein
[Dietary Fats co-treated with Fructose] results in decreased expression of PPARG protein; Carnitine inhibits the reaction [[Dietary Fats co-treated with Fructose] results in decreased expression of PPARG protein]; Fatty Acids, Omega-3 inhibits the reaction [[Dietary Fats co-treated with Fructose] results in decreased expression of PPARG protein]; geraniol inhibits the reaction [Fructose results in decreased activity of PPARG protein]; Metformin inhibits the reaction [[Dietary Fats co-treated with Fructose] results in decreased expression of PPARG protein]; Pioglitazone inhibits the reaction [Fructose results in decreased activity of PPARG protein]; Rosiglitazone promotes the reaction [Fructose results in increased expression of PPARG mRNA]		 CTD PMID:19196556 PMID:25679220 PMID:30256492 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380 		JBrowse link
G Ppargc1a PPARG coactivator 1 alpha decreases expression
increases expression
multiple interactions		 ISO
EXP		 Fructose results in decreased expression of PPARGC1A mRNA
Fructose results in increased expression of PPARGC1A mRNA; Fructose results in increased expression of PPARGC1A protein
2-(3-(4-ethoxybenzyl)-4-chlorophenyl)-6-hydroxymethyltetrahydro-2H-pyran-3,4,5-triol inhibits the reaction [[Fructose co-treated with Dietary Fats] results in decreased expression of PPARGC1A protein]; [Atorvastatin co-treated with 2-(3-(4-ethoxybenzyl)-4-chlorophenyl)-6-hydroxymethyltetrahydro-2H-pyran-3,4,5-triol] inhibits the reaction [[Fructose co-treated with Dietary Fats] results in decreased expression of PPARGC1A protein]; [Fructose co-treated with Dietary Fats] results in decreased expression of PPARGC1A protein; [Ozone co-treated with Fructose] results in decreased expression of PPARGC1A mRNA; [Particulate Matter co-treated with Fructose] results in decreased expression of PPARGC1A mRNA; [Particulate Matter co-treated with Ozone co-treated with Fructose] results in decreased expression of PPARGC1A mRNA; Rosiglitazone inhibits the reaction [Fructose results in increased expression of PPARGC1A protein]		 CTD PMID:18063403 PMID:19196556 PMID:21212096 PMID:23968387 PMID:32259528 NCBI chr14:63,095,291...63,190,688
Ensembl chr14:63,095,720...63,187,009 		JBrowse link
G Prdx6 peroxiredoxin 6 multiple interactions EXP [Fructose co-treated with bisphenol A] results in increased expression of PRDX6 protein CTD PMID:26930160 NCBI chr13:79,077,567...79,088,113
Ensembl chr13:79,077,033...79,088,127 		JBrowse link
G Prkca protein kinase C, alpha multiple interactions EXP [Atorvastatin co-treated with 2-(3-(4-ethoxybenzyl)-4-chlorophenyl)-6-hydroxymethyltetrahydro-2H-pyran-3,4,5-triol] inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of and results in increased phosphorylation of PRKCA protein]; [Fructose co-treated with Dietary Fats] results in increased expression of and results in increased phosphorylation of PRKCA protein CTD PMID:32259528 NCBI chr10:96,186,509...96,585,168
Ensembl chr10:96,191,133...96,584,947 		JBrowse link
G Prkcq protein kinase C, theta multiple interactions
increases phosphorylation		 EXP Curcumin inhibits the reaction [Fructose results in increased phosphorylation of PRKCQ protein] CTD PMID:26713546 NCBI chr17:70,971,915...71,105,286
Ensembl chr17:70,971,915...71,105,286 		JBrowse link
G Prkcz protein kinase C, zeta multiple interactions EXP 2-(3-(4-ethoxybenzyl)-4-chlorophenyl)-6-hydroxymethyltetrahydro-2H-pyran-3,4,5-triol inhibits the reaction [[Fructose co-treated with Dietary Fats] results in decreased expression of PRKCZ protein]; [Atorvastatin co-treated with 2-(3-(4-ethoxybenzyl)-4-chlorophenyl)-6-hydroxymethyltetrahydro-2H-pyran-3,4,5-triol] inhibits the reaction [[Fructose co-treated with Dietary Fats] results in decreased expression of PRKCZ protein]; [Fructose co-treated with Dietary Fats] results in decreased expression of PRKCZ protein CTD PMID:32259528 NCBI chr 5:172,658,071...172,769,492
Ensembl chr 5:172,658,748...172,769,421 		JBrowse link
G Pten phosphatase and tensin homolog multiple interactions
increases expression		 EXP tributylhexadecylphosphonium bromide inhibits the reaction [Fructose results in increased expression of PTEN protein] CTD PMID:26358169 NCBI chr 1:251,421,814...251,487,634
Ensembl chr 1:251,421,596...251,487,832 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression
multiple interactions		 EXP Fructose results in increased expression of PTGS2 mRNA; Fructose results in increased expression of PTGS2 protein
Curcumin inhibits the reaction [Fructose results in increased expression of PTGS2 protein]; Kangen-karyu inhibits the reaction [Fructose results in increased expression of PTGS2 protein]; tributylhexadecylphosphonium bromide inhibits the reaction [Fructose results in increased expression of PTGS2 protein]		 CTD PMID:14757778 PMID:17883899 PMID:26358169 PMID:26713546 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335 		JBrowse link
G Ptma prothymosin alpha multiple interactions EXP PTMA protein inhibits the reaction [Fructose results in increased expression of IL1B protein]; PTMA protein inhibits the reaction [Fructose results in increased expression of IL6 protein] CTD PMID:15885234 NCBI chr 9:93,545,396...93,549,436
Ensembl chr 9:93,545,396...93,549,436 		JBrowse link
G Pura purine rich element binding protein A multiple interactions EXP [Fructose co-treated with bisphenol A] results in increased expression of PURA protein CTD PMID:26930160 NCBI chr18:29,104,712...29,114,918
Ensembl chr18:29,110,242...29,111,156 		JBrowse link
G Pycard PYD and CARD domain containing multiple interactions
increases expression		 EXP Allopurinol inhibits the reaction [Fructose results in increased expression of PYCARD protein]; Quercetin inhibits the reaction [Fructose results in increased expression of PYCARD protein]; Rutin inhibits the reaction [Fructose results in increased expression of PYCARD protein] CTD PMID:22426011 NCBI chr 1:199,438,029...199,439,062
Ensembl chr 1:199,437,832...199,439,210 		JBrowse link
G Pyy peptide YY affects expression EXP Fructose affects the expression of PYY protein CTD PMID:18627777 NCBI chr10:90,047,989...90,049,155
Ensembl chr10:90,047,993...90,049,112 		JBrowse link
G Rbmx RNA binding motif protein, X-linked multiple interactions EXP Fructose promotes the reaction [RBMX protein binds to SREBF1 promoter] CTD PMID:17188681 NCBI chr  X:159,881,835...159,891,405
Ensembl chr  X:159,884,885...159,891,326 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit affects localization
increases phosphorylation
decreases activity
multiple interactions		 EXP Fructose affects the localization of RELA protein
Fructose results in increased phosphorylation of RELA protein
Fructose results in decreased activity of RELA protein
Allopurinol inhibits the reaction [Fructose results in increased phosphorylation of RELA protein]; Betaine inhibits the reaction [Fructose results in decreased activity of RELA protein]; galangin inhibits the reaction [Fructose affects the localization of RELA protein]; Genistein inhibits the reaction [Fructose affects the localization of RELA protein]; Metformin inhibits the reaction [Fructose results in increased phosphorylation of RELA protein]; Quercetin inhibits the reaction [Fructose results in increased phosphorylation of RELA protein]; resveratrol inhibits the reaction [Fructose results in increased phosphorylation of RELA protein]		 CTD PMID:21704028 PMID:21708140 PMID:24491314 PMID:25108154 PMID:25559852 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249 		JBrowse link
G Retn resistin decreases expression
multiple interactions
increases expression		 EXP Fructose results in decreased expression of RETN mRNA
Metformin inhibits the reaction [Fructose results in increased expression of RETN protein]; resveratrol inhibits the reaction [Fructose results in increased expression of RETN protein]		 CTD PMID:11741341 PMID:25108154 NCBI chr12:2,201,909...2,203,649
Ensembl chr12:2,201,891...2,204,249 		JBrowse link
G Rxra retinoid X receptor alpha decreases expression ISO Fructose results in decreased expression of RXRA protein CTD PMID:28257781 NCBI chr 3:6,272,560...6,295,354
Ensembl chr 3:6,211,789...6,295,908 		JBrowse link
G S100a11 S100 calcium binding protein A11 multiple interactions EXP [Fructose co-treated with bisphenol A] results in increased expression of S100A11 protein CTD PMID:26930160 NCBI chr 2:193,863,185...193,868,646
Ensembl chr 2:193,866,951...193,868,502 		JBrowse link
G S100a6 S100 calcium binding protein A6 decreases expression EXP Fructose results in decreased expression of S100A6 mRNA CTD PMID:15150374 NCBI chr 2:190,007,013...190,008,512
Ensembl chr 2:190,007,216...190,008,511 		JBrowse link
G Scarb1 scavenger receptor class B, member 1 decreases expression EXP Fructose results in decreased expression of SCARB1 mRNA CTD PMID:19193814 NCBI chr12:36,694,952...36,761,445
Ensembl chr12:36,694,960...36,761,455 		JBrowse link
G Scd stearoyl-CoA desaturase multiple interactions
increases expression
affects response to substance		 ISO
EXP		 FGF21 gene mutant form inhibits the reaction [Fructose results in increased expression of SCD1 mRNA]; Phenylbutyrates inhibits the reaction [Fructose results in increased expression of SCD1 mRNA]; SCD1 affects the reaction [Fructose results in increased expression of SREBF1 protein]; SCD1 gene mutant form inhibits the reaction [Fructose results in increased abundance of Triglycerides]; SCD1 gene mutant form inhibits the reaction [Fructose results in increased expression of ACACA mRNA]; SCD1 gene mutant form inhibits the reaction [Fructose results in increased expression of FASN mRNA]; SCD1 gene mutant form inhibits the reaction [Fructose results in increased expression of SREBF1 mRNA]; SCD1 gene mutant form inhibits the reaction [Fructose results in increased expression of SREBF1 protein]; Triolein inhibits the reaction [SCD1 gene mutant form inhibits the reaction [Fructose results in increased abundance of Triglycerides]]; Triolein inhibits the reaction [SCD1 gene mutant form inhibits the reaction [Fructose results in increased expression of ACACA mRNA]]; Triolein inhibits the reaction [SCD1 gene mutant form inhibits the reaction [Fructose results in increased expression of FASN mRNA]]; Triolein inhibits the reaction [SCD1 gene mutant form inhibits the reaction [Fructose results in increased expression of SREBF1 mRNA]]; Triolein inhibits the reaction [SCD1 gene mutant form inhibits the reaction [Fructose results in increased expression of SREBF1 protein]]
[Fructose co-treated with Copper deficiency] results in decreased expression of SCD1 mRNA; Atorvastatin inhibits the reaction [Fructose results in increased expression of SCD1 mRNA]; gadolinium chloride promotes the reaction [[Fructose co-treated with Copper deficiency] results in decreased expression of SCD1 mRNA]; Tea inhibits the reaction [Fructose results in increased expression of SCD1 mRNA]
Fructose results in increased expression of SCD mRNA; Fructose results in increased expression of SCD1 mRNA
Fructose results in increased expression of SCD1 mRNA; Fructose results in increased expression of SCD1 protein
SCD1 affects the susceptibility to Fructose		 CTD PMID:7961698 PMID:15066988 PMID:18063403 PMID:19053045 PMID:19193814 PMID:21122807 PMID:22698815 PMID:25813056 PMID:28123933 NCBI chr 1:264,159,966...264,173,061
Ensembl chr 1:264,160,129...264,172,729 		JBrowse link
G Serpine1 serpin family E member 1 increases secretion
increases expression
multiple interactions		 EXP Fructose results in increased secretion of SERPINE1 protein
Fructose results in increased expression of SERPINE1 mRNA; Fructose results in increased expression of SERPINE1 protein
Atorvastatin inhibits the reaction [Fructose results in increased expression of SERPINE1 mRNA]; Metformin inhibits the reaction [Fructose results in increased expression of SERPINE1 protein]; Progesterone inhibits the reaction [Fructose results in increased expression of SERPINE1 mRNA]; Progesterone inhibits the reaction [Fructose results in increased expression of SERPINE1 protein]; Resveratrol inhibits the reaction [Fructose results in increased expression of SERPINE1 protein]		 CTD PMID:19165636 PMID:21122807 PMID:23016136 PMID:25108154 NCBI chr12:22,641,104...22,651,482
Ensembl chr12:22,641,104...22,651,482 		JBrowse link
G Sgk1 serum/glucocorticoid regulated kinase 1 increases expression
multiple interactions		 ISO Fructose results in increased expression of SGK1 mRNA
SGK1 gene affects the susceptibility to [Fructose co-treated with Sodium Chloride, Dietary]		 CTD PMID:16284089 NCBI chr 1:24,185,451...24,302,309
Ensembl chr 1:24,185,435...24,302,298 		JBrowse link
G Shbg sex hormone binding globulin multiple interactions
decreases expression		 ISO Cerulenin inhibits the reaction [Fructose results in decreased expression of SHBG protein]; Fructose affects the reaction [NR2F1 protein binds to SHBG promoter] CTD PMID:17992261 NCBI chr10:56,219,861...56,237,354
Ensembl chr10:56,219,858...56,223,245 		JBrowse link
G Si sucrase-isomaltase increases expression ISO
EXP		 Fructose results in increased expression of SI mRNA CTD PMID:10222385 PMID:11242478 PMID:17786952 NCBI chr 2:170,220,794...170,301,348
Ensembl chr 2:170,221,245...170,301,348 		JBrowse link
G Sirt1 sirtuin 1 multiple interactions
decreases expression
increases expression		 ISO
EXP		 SIRT1 protein affects the reaction [Fructose results in increased expression of MYH6 mRNA]
Fructose results in decreased expression of SIRT1 mRNA; Fructose results in decreased expression of SIRT1 protein
[6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in decreased activity of SIRT1 protein] inhibits the reaction [Fructose results in increased abundance of Cholesterol]; [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in decreased activity of SIRT1 protein] inhibits the reaction [Fructose results in increased abundance of Glucose]; [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in decreased activity of SIRT1 protein] inhibits the reaction [Fructose results in increased expression of ACACA mRNA]; [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in decreased activity of SIRT1 protein] inhibits the reaction [Fructose results in increased expression of HMGCR mRNA]; [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in decreased activity of SIRT1 protein] which results in decreased susceptibility to Fructose; [Niacinamide results in decreased activity of SIRT1 protein] inhibits the reaction [Fructose results in increased abundance of Cholesterol]; [Niacinamide results in decreased activity of SIRT1 protein] inhibits the reaction [Fructose results in increased abundance of Glucose]; [Niacinamide results in decreased activity of SIRT1 protein] inhibits the reaction [Fructose results in increased expression of ACACA mRNA]; [Niacinamide results in decreased activity of SIRT1 protein] inhibits the reaction [Fructose results in increased expression of HMGCR mRNA]; [Niacinamide results in decreased activity of SIRT1 protein] which results in decreased susceptibility to Fructose; Fructose results in increased expression of and results in increased activity of SIRT1 protein; Metformin inhibits the reaction [Fructose results in decreased expression of SIRT1 protein]; resveratrol inhibits the reaction [Fructose results in decreased expression of SIRT1 mRNA]; resveratrol inhibits the reaction [Fructose results in decreased expression of SIRT1 protein]
Fructose results in increased expression of SIRT1 protein		 CTD PMID:18192211 PMID:21212096 PMID:25108154 PMID:26488877 NCBI chr20:26,831,971...26,851,587
Ensembl chr20:26,833,357...26,852,199 		JBrowse link
G Slc22a1 solute carrier family 22 member 1 multiple interactions
decreases expression		 EXP Allopurinol inhibits the reaction [Fructose results in decreased expression of SLC22A1 mRNA]; Allopurinol inhibits the reaction [Fructose results in decreased expression of SLC22A1 protein]; Quercetin inhibits the reaction [Fructose results in decreased expression of SLC22A1 mRNA]; Quercetin inhibits the reaction [Fructose results in decreased expression of SLC22A1 protein]; Rutin inhibits the reaction [Fructose results in decreased expression of SLC22A1 mRNA]; Rutin inhibits the reaction [Fructose results in decreased expression of SLC22A1 protein]
Fructose results in decreased expression of SLC22A1 mRNA; Fructose results in decreased expression of SLC22A1 protein		 CTD PMID:19605544 NCBI chr 1:48,273,639...48,300,645
Ensembl chr 1:48,273,611...48,300,655 		JBrowse link
G Slc22a12 solute carrier family 22 member 12 increases expression
multiple interactions		 EXP Fructose results in increased expression of SLC22A12 mRNA; Fructose results in increased expression of SLC22A12 protein
Allopurinol inhibits the reaction [Fructose results in increased expression of SLC22A12 mRNA]; Allopurinol inhibits the reaction [Fructose results in increased expression of SLC22A12 protein]; Quercetin inhibits the reaction [Fructose results in increased expression of SLC22A12 mRNA]; Quercetin inhibits the reaction [Fructose results in increased expression of SLC22A12 protein]; Rutin inhibits the reaction [Fructose results in increased expression of SLC22A12 mRNA]; Rutin inhibits the reaction [Fructose results in increased expression of SLC22A12 protein]		 CTD PMID:19605544 NCBI chr 1:221,910,787...221,919,277
Ensembl chr 1:221,910,767...221,919,301 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions
decreases expression		 EXP Allopurinol inhibits the reaction [Fructose results in decreased expression of SLC22A2 mRNA]; Allopurinol inhibits the reaction [Fructose results in decreased expression of SLC22A2 protein]; Quercetin inhibits the reaction [Fructose results in decreased expression of SLC22A2 mRNA]; Quercetin inhibits the reaction [Fructose results in decreased expression of SLC22A2 protein]; Rutin inhibits the reaction [Fructose results in decreased expression of SLC22A2 mRNA]; Rutin inhibits the reaction [Fructose results in decreased expression of SLC22A2 protein]
Fructose results in decreased expression of SLC22A2 mRNA; Fructose results in decreased expression of SLC22A2 protein		 CTD PMID:19605544 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261 		JBrowse link
G Slc22a5 solute carrier family 22 member 5 decreases expression
multiple interactions		 EXP Fructose results in decreased expression of SLC22A5 protein
Allopurinol inhibits the reaction [Fructose results in decreased expression of SLC22A5 protein]; Quercetin inhibits the reaction [Fructose results in decreased expression of SLC22A5 protein]		 CTD PMID:22426011 NCBI chr10:39,201,101...39,228,090
Ensembl chr10:39,201,107...39,323,853 		JBrowse link
G Slc22a6 solute carrier family 22 member 6 multiple interactions
decreases expression		 EXP Allopurinol inhibits the reaction [Fructose results in decreased expression of SLC22A6 mRNA]; Allopurinol inhibits the reaction [Fructose results in decreased expression of SLC22A6 protein]; Quercetin inhibits the reaction [Fructose results in decreased expression of SLC22A6 mRNA]; Quercetin inhibits the reaction [Fructose results in decreased expression of SLC22A6 protein]; Rutin inhibits the reaction [Fructose results in decreased expression of SLC22A6 mRNA]; Rutin inhibits the reaction [Fructose results in decreased expression of SLC22A6 protein]
Fructose results in decreased expression of SLC22A6 mRNA; Fructose results in decreased expression of SLC22A6 protein		 CTD PMID:19605544 NCBI chr 1:224,824,809...224,833,284
Ensembl chr 1:224,824,799...224,833,259 		JBrowse link
G Slc25a5 solute carrier family 25 member 5 multiple interactions EXP [Fructose co-treated with bisphenol A] results in decreased expression of SLC25A5 protein CTD PMID:26930160 NCBI chr  X:123,404,570...123,407,637
Ensembl chr  X:123,404,518...123,407,645 		JBrowse link
G Slc27a2 solute carrier family 27 member 2 decreases expression ISO Fructose results in decreased expression of SLC27A2 protein CTD PMID:28257781 NCBI chr 3:119,014,620...119,052,531
Ensembl chr 3:119,014,620...119,052,531 		JBrowse link
G Slc2a2 solute carrier family 2 member 2 multiple interactions
increases expression
increases transport		 ISO
EXP		 Fructose inhibits the reaction [SLC2A2 protein results in increased transport of Deoxyglucose]; Glucose inhibits the reaction [SLC2A2 protein results in increased transport of Fructose]; Maltose inhibits the reaction [SLC2A2 protein results in increased transport of Fructose]
Fructose results in increased expression of SLC2A2 mRNA
Dactinomycin inhibits the reaction [Fructose results in increased expression of SLC2A2 mRNA]
Fructose results in increased expression of and affects the localization of SLC2A2 protein		 CTD PMID:1727734 PMID:8457197 PMID:10222385 PMID:12787936 PMID:12937289 PMID:17710649 PMID:17786952 NCBI chr 2:114,413,427...114,445,418
Ensembl chr 2:114,413,410...114,445,395 		JBrowse link
G Slc2a4 solute carrier family 2 member 4 decreases expression
multiple interactions
increases expression		 ISO
EXP		 Fructose results in decreased expression of SLC2A4 mRNA
[Dietary Fats co-treated with Fructose] results in decreased expression of SLC2A4 protein; Carnitine inhibits the reaction [[Dietary Fats co-treated with Fructose] results in decreased expression of SLC2A4 protein]; Fatty Acids, Omega-3 inhibits the reaction [[Dietary Fats co-treated with Fructose] results in decreased expression of SLC2A4 protein]; Metformin inhibits the reaction [[Dietary Fats co-treated with Fructose] results in decreased expression of SLC2A4 protein]
Fructose results in increased expression of SLC2A4 mRNA		 CTD PMID:15111496 PMID:18063403 PMID:30256492 NCBI chr10:56,552,921...56,558,562
Ensembl chr10:56,552,983...56,558,487 		JBrowse link
G Slc2a5 solute carrier family 2 member 5 multiple interactions
increases activity
increases expression
increases transport
increases uptake
affects expression		 ISO
EXP		 [Fructose results in increased abundance of Cyclic AMP] which results in increased stability of SLC2A5 mRNA; Colforsin promotes the reaction [Fructose results in increased expression of SLC2A5 mRNA]; Fructose promotes the reaction [PAIP2 protein binds to SLC2A5 3' UTR]
Fructose results in increased activity of SLC2A5 protein
SLC2A5 protein results in increased transport of Fructose
Fructose results in increased expression of SLC2A5 mRNA; Fructose results in increased expression of SLC2A5 protein
SLC2A5 protein results in increased uptake of Fructose
Fructose affects the expression of SLC2A5 mRNA
Fructose analog results in increased expression of SLC2A5 mRNA; Fructose results in increased expression of SLC2A5 mRNA; Fructose results in increased expression of SLC2A5 protein
1-((1-O-octadecyl-2-O-methylglycero)phospho)-3-deoxy-myo-inositol inhibits the reaction [Fructose results in increased expression of and results in increased activity of SLC2A5 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Fructose results in increased expression of and results in increased activity of SLC2A5 protein]; [[Colforsin results in increased abundance of Cyclic AMP] which results in increased expression of SLC2A5 protein] which results in increased uptake of Fructose; [Triiodothyronine co-treated with Fructose] results in increased expression of SLC2A5 mRNA; Cycloheximide inhibits the reaction [Fructose promotes the reaction [SLC2A5 protein results in increased uptake of Fructose]]; Dactinomycin inhibits the reaction [Fructose promotes the reaction [SLC2A5 protein results in increased uptake of Fructose]]; Dactinomycin inhibits the reaction [Fructose results in increased expression of SLC2A5 mRNA]; Dexamethasone promotes the reaction [Fructose results in increased activity of SLC2A5 protein]; Dexamethasone promotes the reaction [Fructose results in increased expression of SLC2A5 mRNA]; Fructose analog results in increased activity of [SLC2A5 protein results in increased uptake of Fructose]; Fructose promotes the reaction [SLC2A5 protein results in increased transport of Fructose]; Fructose promotes the reaction [SLC2A5 protein results in increased uptake of Fructose]; Fructose results in increased expression of and results in increased activity of SLC2A5 protein; Mifepristone inhibits the reaction [Dexamethasone promotes the reaction [Fructose results in increased activity of SLC2A5 protein]]; Mifepristone inhibits the reaction [Dexamethasone promotes the reaction [Fructose results in increased expression of SLC2A5 mRNA]]; Vanadates inhibits the reaction [Fructose results in increased activity of SLC2A5 protein]; Vanadates inhibits the reaction [Fructose results in increased expression of SLC2A5 mRNA]; wortmannin inhibits the reaction [Fructose results in increased expression of and results in increased activity of SLC2A5 protein]
lactisole inhibits the reaction [Fructose results in increased expression of SLC2A5 mRNA]		 CTD PMID:1634504 PMID:8037665 PMID:8048533 PMID:8404647 PMID:8554516 PMID:9078534 PMID:9124564 PMID:9486174 PMID:9606981 PMID:10222385 PMID:10554124 PMID:11123204 PMID:11242478 PMID:11518678 PMID:12031501 PMID:12820898 PMID:12937289 PMID:15150374 PMID:15226456 PMID:15457374 PMID:15691865 PMID:16581195 PMID:16920846 PMID:16960373 PMID:17485832 PMID:17710649 PMID:17786952 PMID:18400728 PMID:18556366 PMID:19907007 NCBI chr 5:167,142,182...167,174,203
Ensembl chr 5:167,141,875...167,174,310 		JBrowse link
G Slc2a7 solute carrier family 2 member 7 increases transport ISO SLC2A7 protein results in increased transport of Fructose CTD PMID:15033637 PMID:17710649 NCBI chr 5:167,195,981...167,211,613
Ensembl chr 5:167,195,981...167,211,391 		JBrowse link
G Slc2a9 solute carrier family 2 member 9 increases transport
increases expression
multiple interactions		 ISO
EXP		 SLC2A9 protein results in increased transport of Fructose
Fructose results in increased expression of SLC2A9 mRNA SNP; Fructose results in increased expression of SLC2A9 protein SNP
Allopurinol inhibits the reaction [Fructose results in increased expression of SLC2A9 mRNA SNP]; Allopurinol inhibits the reaction [Fructose results in increased expression of SLC2A9 protein SNP]; Quercetin inhibits the reaction [Fructose results in increased expression of SLC2A9 mRNA SNP]; Quercetin inhibits the reaction [Fructose results in increased expression of SLC2A9 protein SNP]; Rutin inhibits the reaction [Fructose results in increased expression of SLC2A9 mRNA SNP]; Rutin inhibits the reaction [Fructose results in increased expression of SLC2A9 protein SNP]
Fructose promotes the reaction [SLC2A9 protein alternative form results in increased transport of Uric Acid]		 CTD PMID:17710649 PMID:18842065 PMID:19605544 NCBI chr14:77,067,537...77,192,702
Ensembl chr14:77,067,503...77,192,702 		JBrowse link
G Slc31a1 solute carrier family 31 member 1 multiple interactions EXP Fructose inhibits the reaction [Copper deficiency results in increased expression of SLC31A1 protein] CTD PMID:21781943 NCBI chr 5:78,222,504...78,249,358
Ensembl chr 5:78,222,504...78,249,358 		JBrowse link
G Slc34a2 solute carrier family 34 member 2 decreases expression
multiple interactions
affects expression		 EXP Fructose results in decreased expression of SLC34A2 mRNA
tungstate promotes the reaction [Fructose results in decreased expression of SLC34A2 mRNA]; Vanadates promotes the reaction [Fructose results in decreased expression of SLC34A2 mRNA]
Fructose affects the expression of SLC34A2 mRNA		 CTD PMID:15150374 PMID:18400728 NCBI chr14:60,257,211...60,276,516
Ensembl chr14:60,256,712...60,276,794 		JBrowse link
G Slc37a4 solute carrier family 37 member 4 increases expression EXP Fructose results in increased expression of SLC37A4 mRNA CTD PMID:16920846 NCBI chr 8:48,716,914...48,723,024
Ensembl chr 8:48,716,939...48,723,024 		JBrowse link
G Slc46a1 solute carrier family 46 member 1 multiple interactions EXP [Folic Acid affects the susceptibility to Fructose] which affects the expression of SLC46A1 mRNA CTD PMID:31612177 NCBI chr10:65,728,508...65,741,708
Ensembl chr10:65,733,991...65,740,828 		JBrowse link
G Slc5a1 solute carrier family 5 member 1 multiple interactions
increases expression		 ISO
EXP		 lactisole inhibits the reaction [Fructose results in increased expression of SLC5A1 mRNA]
Fructose results in increased expression of SLC5A1 mRNA; Fructose results in increased expression of SLC5A1 protein		 CTD PMID:8048533 PMID:10222385 PMID:11242478 PMID:12937289 PMID:17786952 NCBI chr14:82,910,448...82,975,303
Ensembl chr14:82,909,981...82,975,263 		JBrowse link
G Slc8a1 solute carrier family 8 member A1 multiple interactions ISO [Fructose co-treated with Dietary Fats] results in decreased expression of SLC8A1 mRNA; troxerutin inhibits the reaction [[Fructose co-treated with Dietary Fats] results in decreased expression of SLC8A1 mRNA] CTD PMID:28916335 NCBI chr 6:4,244,076...4,564,262
Ensembl chr 6:4,258,991...4,520,604 		JBrowse link
G Soat2 sterol O-acyltransferase 2 decreases expression EXP Fructose results in decreased expression of SOAT2 mRNA CTD PMID:19193814 NCBI chr 7:143,754,892...143,767,989
Ensembl chr 7:143,754,892...143,767,989 		JBrowse link
G Socs3 suppressor of cytokine signaling 3 increases expression
multiple interactions		 EXP Fructose results in increased expression of SOCS3 mRNA; Fructose results in increased expression of SOCS3 protein
[Fenofibrate co-treated with Resveratrol] inhibits the reaction [Fructose results in increased expression of SOCS3 mRNA]; Fenofibrate inhibits the reaction [Fructose results in increased expression of SOCS3 mRNA]; Quercetin inhibits the reaction [Fructose results in increased expression of SOCS3 protein]; Resveratrol inhibits the reaction [Fructose results in increased expression of SOCS3 mRNA]; Rutin inhibits the reaction [Fructose results in increased expression of SOCS3 protein]		 CTD PMID:21122807 PMID:22426011 PMID:23533474 PMID:26973390 NCBI chr10:106,973,863...106,976,969
Ensembl chr10:106,975,178...106,976,040 		JBrowse link
G Sod1 superoxide dismutase 1 affects binding
decreases expression
multiple interactions
decreases activity
increases activity		 ISO
EXP		 Fructose binds to SOD1 protein mutant form
Fructose results in decreased expression of SOD1 mRNA; Fructose results in decreased expression of SOD1 protein
[Fructose co-treated with Copper deficiency] results in decreased expression of SOD1 protein
Fructose results in decreased activity of SOD1 protein
Fructose results in increased activity of SOD1 protein
Fructose promotes the reaction [SOD1 protein mutant form results in increased chemical synthesis of Hydrogen Peroxide]		 CTD PMID:11817707 PMID:12626432 PMID:16815490 PMID:20470786 PMID:21781943 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862 		JBrowse link
G Sord sorbitol dehydrogenase multiple interactions
increases glycation		 EXP
ISO		 [Fructose results in increased glycation of SORD protein] which results in decreased activity of SORD protein
[SORD protein results in increased metabolism of Sorbitol] which results in increased abundance of Fructose		 CTD PMID:8761460 PMID:32367058 NCBI chr 3:114,176,127...114,207,368
Ensembl chr 3:114,176,309...114,207,366 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions
increases expression
affects localization
affects response to substance		 ISO
EXP		 Phenylbutyrates inhibits the reaction [Fructose affects the localization of SREBF1 protein alternative form]; Phenylbutyrates inhibits the reaction [Fructose results in increased expression of SREBF1 mRNA]; SCD1 affects the reaction [Fructose results in increased expression of SREBF1 protein]; SCD1 gene mutant form inhibits the reaction [Fructose results in increased expression of SREBF1 mRNA]; SCD1 gene mutant form inhibits the reaction [Fructose results in increased expression of SREBF1 protein]; Triolein inhibits the reaction [SCD1 gene mutant form inhibits the reaction [Fructose results in increased expression of SREBF1 mRNA]]; Triolein inhibits the reaction [SCD1 gene mutant form inhibits the reaction [Fructose results in increased expression of SREBF1 protein]]
Fructose results in increased expression of SREBF1 mRNA; Fructose results in increased expression of SREBF1 protein
2-(3-(4-ethoxybenzyl)-4-chlorophenyl)-6-hydroxymethyltetrahydro-2H-pyran-3,4,5-triol inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of SREBF1 protein]; [Atorvastatin co-treated with 2-(3-(4-ethoxybenzyl)-4-chlorophenyl)-6-hydroxymethyltetrahydro-2H-pyran-3,4,5-triol] inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of SREBF1 protein]; [Fenofibrate co-treated with Resveratrol] inhibits the reaction [Fructose results in increased expression of SREBF1 mRNA]; [Fructose co-treated with Copper deficiency] results in increased expression of SREBF1 protein; [Fructose co-treated with Dietary Fats] results in increased expression of SREBF1 protein; Atorvastatin inhibits the reaction [Fructose results in increased activity of SREBF1 protein]; Fructose promotes the reaction [RBMX protein binds to SREBF1 promoter]; Fructose results in increased expression of and results in increased activity of SREBF1 protein; gadolinium chloride inhibits the reaction [[Fructose co-treated with Copper deficiency] results in increased expression of SREBF1 protein]; Resveratrol inhibits the reaction [Fructose results in increased expression of SREBF1 mRNA]; Rosiglitazone inhibits the reaction [Fructose results in increased expression of SREBF1 mRNA]; Tea inhibits the reaction [Fructose results in increased expression of SREBF1 mRNA]
SREBF1 promoter SNP affects the susceptibility to Fructose		 CTD PMID:10913129 PMID:11934685 PMID:15066988 PMID:15123654 PMID:17188681 PMID:18346472 PMID:19053045 PMID:19193814 PMID:19196556 PMID:19799862 PMID:22698815 PMID:25813056 PMID:26973390 PMID:32259528 NCBI chr10:46,570,996...46,593,021
Ensembl chr10:46,570,996...46,593,009 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 increases phosphorylation
decreases phosphorylation
multiple interactions		 EXP Fructose results in increased phosphorylation of STAT3 protein
Fructose results in decreased phosphorylation of STAT3 protein
Quercetin inhibits the reaction [Fructose results in decreased phosphorylation of STAT3 protein]; Quercetin inhibits the reaction [Fructose results in increased phosphorylation of STAT3 protein]; Rutin inhibits the reaction [Fructose results in increased phosphorylation of STAT3 protein]		 CTD PMID:22426011 PMID:23533474 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233 		JBrowse link
G Steap4 STEAP4 metalloreductase multiple interactions EXP [Dietary Fats co-treated with Fructose] results in increased expression of STEAP4 mRNA CTD PMID:19632207 NCBI chr 4:23,112,682...23,135,354
Ensembl chr 4:23,090,029...23,135,354 		JBrowse link
G Tfam transcription factor A, mitochondrial increases expression EXP Fructose results in increased expression of TFAM protein CTD PMID:11934685 NCBI chr20:18,594,057...18,606,106
Ensembl chr20:18,594,037...18,606,151 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 decreases expression
multiple interactions
increases expression		 EXP
ISO		 Fructose results in decreased expression of TGFB1 mRNA
[FGF21 gene mutant form results in increased susceptibility to Fructose] which results in increased expression of TGFB1 mRNA
Fructose results in increased expression of TGFB1 mRNA; Fructose results in increased expression of TGFB1 protein
2-(3-(4-ethoxybenzyl)-4-chlorophenyl)-6-hydroxymethyltetrahydro-2H-pyran-3,4,5-triol inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of and results in increased secretion of TGFB1 protein]; 2-(3-(4-ethoxybenzyl)-4-chlorophenyl)-6-hydroxymethyltetrahydro-2H-pyran-3,4,5-triol promotes the reaction [Metformin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of and results in increased secretion of TGFB1 protein]]; [Fenofibrate co-treated with Resveratrol] inhibits the reaction [Fructose results in increased expression of TGFB1 mRNA]; [Streptozocin co-treated with Fructose] results in increased expression of and results in increased secretion of TGFB1 protein; betanin inhibits the reaction [Fructose results in increased expression of TGFB1 protein]; Fenofibrate inhibits the reaction [Fructose results in increased expression of TGFB1 mRNA]; galangin inhibits the reaction [Fructose results in increased expression of TGFB1 protein]; Genistein inhibits the reaction [Fructose results in increased expression of TGFB1 protein]; Metformin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of and results in increased secretion of TGFB1 protein]; Resveratrol inhibits the reaction [Fructose results in increased expression of TGFB1 mRNA]		 CTD PMID:15150374 PMID:21704028 PMID:21708140 PMID:25559852 PMID:26973390 PMID:28123933 PMID:30551545 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199 		JBrowse link
G Tgfb2 transforming growth factor, beta 2 multiple interactions ISO [FGF21 gene mutant form results in increased susceptibility to Fructose] which results in increased expression of TGFB2 mRNA CTD PMID:28123933 NCBI chr13:105,039,639...105,142,010
Ensembl chr13:105,039,853...105,141,030 		JBrowse link
G Th tyrosine hydroxylase increases expression ISO Fructose results in increased expression of TH mRNA CTD PMID:16843071 NCBI chr 1:216,073,034...216,080,287
Ensembl chr 1:216,073,031...216,080,287 		JBrowse link
G Thrsp thyroid hormone responsive multiple interactions EXP Fructose inhibits the reaction [Streptozocin results in decreased expression of THRSP mRNA] CTD PMID:2177838 NCBI chr 1:162,381,251...162,385,575
Ensembl chr 1:162,381,253...162,385,575 		JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions
increases expression		 EXP
ISO		 [gadolinium chloride co-treated with Fructose co-treated with Copper deficiency] results in decreased expression of TLR4 mRNA
Fructose results in increased expression of TLR4 protein
[Fructose co-treated with Ethanol] results in increased expression of TLR4 mRNA		 CTD PMID:25813056 PMID:26858005 PMID:31672515 NCBI chr 5:82,587,424...82,601,056
Ensembl chr 5:82,587,420...82,601,052 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases secretion
increases expression		 EXP
ISO		 2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [caryophyllene inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of TNF protein]]; 2-(3-(4-ethoxybenzyl)-4-chlorophenyl)-6-hydroxymethyltetrahydro-2H-pyran-3,4,5-triol inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of and results in increased secretion of TNF protein]; 2-(3-(4-ethoxybenzyl)-4-chlorophenyl)-6-hydroxymethyltetrahydro-2H-pyran-3,4,5-triol promotes the reaction [Metformin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of and results in increased secretion of TNF protein]]; [Dietary Fats co-treated with Fructose] results in increased expression of TNF protein; [Fenofibrate co-treated with Resveratrol] inhibits the reaction [Fructose results in increased expression of and results in increased secretion of TNF protein]; [gadolinium chloride co-treated with Fructose co-treated with Copper deficiency] results in decreased expression of TNF mRNA; [Particulate Matter co-treated with Ozone] promotes the reaction [Fructose results in increased expression of TNF mRNA]; [Streptozocin co-treated with Fructose] results in increased expression of and results in increased secretion of TNF protein; Allopurinol inhibits the reaction [Fructose results in increased expression of TNF protein]; caffeic acid phenethyl ester inhibits the reaction [Fructose results in increased expression of TNF protein]; caryophyllene inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of TNF protein]; Curcumin inhibits the reaction [Fructose results in increased expression of TNF protein]; Fenofibrate inhibits the reaction [Fructose results in increased expression of and results in increased secretion of TNF protein]; Fructose inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of TNF protein]; Fructose results in increased expression of and results in increased secretion of TNF protein; galangin inhibits the reaction [Fructose results in increased expression of TNF mRNA]; galangin inhibits the reaction [Fructose results in increased expression of TNF protein]; Genistein inhibits the reaction [Fructose results in increased expression of TNF protein]; geraniol inhibits the reaction [Fructose results in increased secretion of TNF protein]; iodopravadoline inhibits the reaction [caryophyllene inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of TNF protein]]; Metformin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of and results in increased secretion of TNF protein]; Metformin inhibits the reaction [Fructose results in increased expression of TNF protein]; Ozone promotes the reaction [Fructose results in increased expression of TNF mRNA]; Particulate Matter promotes the reaction [Fructose results in increased expression of TNF mRNA]; Pioglitazone inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of TNF protein]; Pioglitazone inhibits the reaction [Fructose results in increased secretion of TNF protein]; Quercetin inhibits the reaction [Fructose results in increased expression of TNF protein]; Resveratrol inhibits the reaction [Fructose results in increased expression of and results in increased secretion of TNF protein]; Resveratrol inhibits the reaction [Fructose results in increased expression of TNF protein]; Rutin inhibits the reaction [Fructose results in increased expression of TNF protein]; tributylhexadecylphosphonium bromide inhibits the reaction [Fructose results in increased expression of TNF protein]
Fructose promotes the reaction [Ethanol results in increased expression of TNF mRNA]
Fructose results in increased expression of TNF mRNA; Fructose results in increased expression of TNF protein		 CTD PMID:10090849 PMID:21704028 PMID:21708140 PMID:22426011 PMID:23968387 PMID:24508943 PMID:25108154 PMID:25679220 PMID:25813056 PMID:26358169 PMID:26713546 PMID:26858005 PMID:26973390 PMID:27531227 PMID:28257781 PMID:30343038 PMID:30551545 PMID:31672515 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000 		JBrowse link
G Traf6 TNF receptor associated factor 6 multiple interactions ISO Fructose inhibits the reaction [Ethanol results in increased expression of TRAF6 protein]; Fructose promotes the reaction [Ethanol results in increased expression of TRAF6 mRNA] CTD PMID:26858005 NCBI chr 3:91,252,829...91,271,607
Ensembl chr 3:91,252,829...91,271,607 		JBrowse link
G Trap1 TNF receptor-associated protein 1 multiple interactions
decreases expression		 EXP [Fructose co-treated with bisphenol A] results in increased expression of TRAP1 protein
Fructose results in decreased expression of TRAP1 protein		 CTD PMID:26930160 NCBI chr10:11,724,032...11,757,682
Ensembl chr10:11,724,032...11,757,681 		JBrowse link
G Trib3 tribbles pseudokinase 3 increases expression
multiple interactions		 EXP
ISO		 Fructose results in increased expression of TRIB3 mRNA
Phenylbutyrates inhibits the reaction [Fructose results in increased expression of TRIB3 mRNA]		 CTD PMID:18497449 PMID:22698815 NCBI chr 3:147,814,056...147,819,650
Ensembl chr 3:147,813,473...147,819,571 		JBrowse link
G Ttr transthyretin multiple interactions EXP [Fructose co-treated with bisphenol A] results in increased expression of TTR protein CTD PMID:26930160 NCBI chr18:15,532,963...15,542,180
Ensembl chr18:15,532,963...15,540,177 		JBrowse link
G Txnip thioredoxin interacting protein increases expression
multiple interactions		 EXP Fructose results in increased expression of TXNIP protein
Allopurinol inhibits the reaction [Fructose results in increased expression of TXNIP protein]; Quercetin inhibits the reaction [Fructose results in increased expression of TXNIP protein]		 CTD PMID:24491314 NCBI chr 2:198,683,168...198,686,971
Ensembl chr 2:198,683,159...198,686,974 		JBrowse link
G Ucp1 uncoupling protein 1 multiple interactions
decreases expression		 EXP Fructose promotes the reaction [[Ozone co-treated with Particulate Matter] results in decreased expression of UCP1 mRNA]; Fructose promotes the reaction [Ozone results in decreased expression of UCP1 mRNA]; Fructose promotes the reaction [Particulate Matter results in decreased expression of UCP1 mRNA]
Fructose results in decreased expression of UCP1 mRNA		 CTD PMID:23968387 NCBI chr19:24,456,976...24,464,808
Ensembl chr19:24,456,976...24,464,807 		JBrowse link
G Ucp3 uncoupling protein 3 increases expression EXP Fructose results in increased expression of UCP3 protein CTD PMID:11934685 NCBI chr 1:165,482,912...165,495,895
Ensembl chr 1:165,482,155...165,496,206 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 increases expression
multiple interactions		 EXP
ISO		 Fructose results in increased expression of VCAM1 mRNA
2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [caryophyllene inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of VCAM1 protein]]; [Dietary Fats co-treated with Fructose] results in increased expression of VCAM1 protein; caryophyllene inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of VCAM1 protein]; iodopravadoline inhibits the reaction [caryophyllene inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of VCAM1 protein]]; Pioglitazone inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of VCAM1 protein]		 CTD PMID:17587757 PMID:30343038 PMID:31655124 NCBI chr 2:219,071,193...219,090,931
Ensembl chr 2:219,071,193...219,097,619 		JBrowse link
G Vcl vinculin multiple interactions
decreases expression		 EXP [Fructose co-treated with bisphenol A] results in decreased expression of VCL protein
Fructose results in decreased expression of VCL protein		 CTD PMID:26930160 NCBI chr15:3,455,211...3,544,738
Ensembl chr15:3,455,211...3,544,702 		JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions EXP [bisphenol A co-treated with Fructose] results in increased expression of VEGFA mRNA CTD PMID:27622962 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681 		JBrowse link
G Vldlr very low density lipoprotein receptor multiple interactions ISO [PPARD mRNA results in decreased susceptibility to Fructose] which results in decreased expression of VLDLR mRNA; Fructose inhibits the reaction [PPARD mRNA results in decreased expression of VLDLR mRNA]; Fructose promotes the reaction [PPARD gene mutant form results in increased expression of VLDLR mRNA]; Fructose promotes the reaction [PPARD gene mutant form results in increased expression of VLDLR protein] CTD PMID:29289645 NCBI chr 1:245,236,819...245,273,688
Ensembl chr 1:245,237,736...245,269,205 		JBrowse link
G Vnn1 vanin 1 multiple interactions EXP 2-(3-(4-ethoxybenzyl)-4-chlorophenyl)-6-hydroxymethyltetrahydro-2H-pyran-3,4,5-triol inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of VNN1 mRNA]; [Streptozocin co-treated with Fructose] results in increased expression of VNN1 mRNA; Metformin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of VNN1 mRNA] CTD PMID:30551545 NCBI chr 1:22,614,832...22,625,134
Ensembl chr 1:22,614,783...22,625,204 		JBrowse link
G Xbp1 X-box binding protein 1 affects localization ISO Fructose affects the localization of XBP1 protein CTD PMID:22698815 NCBI chr14:85,753,736...85,758,820
Ensembl chr14:85,753,760...85,758,145 		JBrowse link
G Xdh xanthine dehydrogenase multiple interactions
increases activity		 ISO
EXP		 Fructose promotes the reaction [XDH protein results in increased chemical synthesis of Uric Acid]; XDH protein promotes the reaction [Fructose results in increased abundance of Reactive Oxygen Species]
Glutamine inhibits the reaction [Fructose results in increased activity of XDH protein]		 CTD PMID:19158351 PMID:31233715 NCBI chr 6:25,149,570...25,211,273
Ensembl chr 6:25,149,235...25,211,494 		JBrowse link
G Ybx3 Y box binding protein 3 multiple interactions EXP [Fructose co-treated with bisphenol A] results in increased expression of YBX3 protein CTD PMID:26930160 NCBI chr 4:165,606,819...165,630,041
Ensembl chr 4:165,606,819...165,630,118 		JBrowse link
keto-D-fructose 1,6-bisphosphate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gapdh glyceraldehyde-3-phosphate dehydrogenase multiple interactions EXP [GAPDH protein co-treated with fructose-1,6-diphosphate co-treated with NAD] results in increased chemical synthesis of sodium arsenite; [GAPDH protein co-treated with fructose-1,6-diphosphate co-treated with NAD] results in increased reduction of sodium arsenate analog; heptelidic acid inhibits the reaction [[GAPDH protein co-treated with fructose-1,6-diphosphate co-treated with NAD] results in increased reduction of sodium arsenate analog] CTD PMID:15788719 NCBI chr 4:157,676,336...157,680,322
Ensembl chr 4:157,676,595...157,679,962 		JBrowse link
G Idh2 isocitrate dehydrogenase (NADP(+)) 2 multiple interactions
increases abundance		 ISO Triazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of fructose-1,6-diphosphate] CTD PMID:27469509 NCBI chr 1:141,874,354...141,893,674
Ensembl chr 1:141,866,283...141,893,705 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO fructose-1,6-diphosphate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein] CTD PMID:22227475 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO fructose-1,6-diphosphate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein] CTD PMID:22227475 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
decreases degradation		 ISO fructose-1,6-diphosphate inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; fructose-1,6-diphosphate inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]
fructose-1,6-diphosphate results in decreased degradation of NOS2 mRNA		 CTD PMID:22227475 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190 		JBrowse link
psicose term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO psicose inhibits the reaction [Glucose results in increased expression of CCL2 mRNA]; psicose inhibits the reaction [Glucose results in increased expression of CCL2 protein] CTD PMID:17655880 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870 		JBrowse link
royal jelly term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO royal jelly inhibits the reaction [Nicotine results in decreased expression of BCL2 mRNA] CTD PMID:30896085 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO royal jelly inhibits the reaction [Nicotine results in increased expression of CASP3 mRNA] CTD PMID:30896085 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204 		JBrowse link
G Cat catalase multiple interactions EXP
ISO		 royal jelly inhibits the reaction [Cisplatin results in decreased activity of CAT protein]
royal jelly inhibits the reaction [Nicotine results in decreased activity of CAT protein]		 CTD PMID:20369241 PMID:30896085 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058 		JBrowse link
G Esr1 estrogen receptor 1 multiple interactions
increases activity
affects binding		 ISO Estradiol inhibits the reaction [royal jelly binds to ESR1 protein]; royal jelly binds to and results in increased activity of ESR1 protein; royal jelly inhibits the reaction [Estradiol binds to ESR1 protein]
royal jelly results in increased activity of ESR1 protein		 CTD PMID:15946813 PMID:17287592 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796 		JBrowse link
G Esr2 estrogen receptor 2 multiple interactions
affects binding		 ISO Estradiol inhibits the reaction [royal jelly binds to ESR2 protein]; royal jelly binds to and results in increased activity of ESR2 protein; royal jelly inhibits the reaction [Estradiol binds to ESR2 protein] CTD PMID:15946813 PMID:17287592 NCBI chr 6:99,163,953...99,214,711
Ensembl chr 6:99,164,357...99,214,251 		JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions ISO royal jelly inhibits the reaction [Nicotine results in decreased expression of PCNA protein] CTD PMID:30896085 NCBI chr 3:124,880,698...124,884,570
Ensembl chr 3:124,880,698...124,884,570 		JBrowse link
G Tff1 trefoil factor 1 increases expression ISO royal jelly results in increased expression of TFF1 mRNA CTD PMID:15946813 NCBI chr20:9,892,124...9,895,984
Ensembl chr20:9,892,124...9,895,984 		JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO royal jelly inhibits the reaction [Nicotine results in increased expression of TRP53 mRNA] CTD PMID:30896085 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449 		JBrowse link
G Vegfa vascular endothelial growth factor A increases expression ISO
EXP		 royal jelly results in increased expression of VEGFA mRNA CTD PMID:15946813 PMID:17287592 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681 		JBrowse link
sorbose term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Oat ornithine aminotransferase multiple interactions
decreases activity		 EXP Sorbose inhibits the reaction [Cyclic AMP results in increased activity of OAT protein]
Sorbose results in decreased activity of OAT protein		 CTD PMID:2827574 NCBI chr 1:204,562,289...204,582,070
Ensembl chr 1:204,562,289...204,582,070 		JBrowse link
tagatose term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl2 C-C motif chemokine ligand 2 increases secretion ISO tagatose results in increased secretion of CCL2 protein CTD PMID:19158351 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870 		JBrowse link
topiramate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions
increases expression		 EXP Amino Acids, Peptides, and Proteins inhibits the reaction [topiramate results in increased expression of ABCB1 protein] CTD PMID:18473823 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515 		JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 increases expression EXP topiramate results in increased expression of ABCC1 protein CTD PMID:18473823 NCBI chr10:549,537...672,235
Ensembl chr10:549,883...672,196 		JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 increases expression EXP topiramate results in increased expression of ABCC2 protein CTD PMID:18473823 NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252 		JBrowse link
G Acadsb acyl-CoA dehydrogenase, short/branched chain increases expression EXP topiramate results in increased expression of ACADSB mRNA CTD PMID:16979414 NCBI chr 1:201,981,362...202,022,771
Ensembl chr 1:201,981,357...202,021,008 		JBrowse link
G Acsl4 acyl-CoA synthetase long-chain family member 4 decreases expression EXP topiramate results in decreased expression of ACSL4 mRNA CTD PMID:16979414 NCBI chr  X:113,596,247...113,660,024
Ensembl chr  X:113,596,239...113,659,944 		JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing increases expression
increases secretion		 ISO topiramate results in increased expression of ADIPOQ mRNA
topiramate results in increased secretion of ADIPOQ protein		 CTD PMID:12927809 NCBI chr11:81,330,845...81,344,488
Ensembl chr11:81,330,293...81,344,488 		JBrowse link
G Adra2a adrenoceptor alpha 2A increases expression ISO topiramate results in increased expression of ADRA2A mRNA CTD PMID:22489711 NCBI chr 1:274,766,283...274,769,083
Ensembl chr 1:274,766,283...274,769,081 		JBrowse link
G Agxt alanine--glyoxylate and serine--pyruvate aminotransferase increases expression EXP topiramate results in increased expression of AGXT mRNA CTD PMID:16979414 NCBI chr 9:100,281,339...100,291,292
Ensembl chr 9:100,281,339...100,291,291 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions EXP topiramate inhibits the reaction [3-nitropropionic acid results in decreased phosphorylation of AKT1 protein] CTD PMID:29753867 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258 		JBrowse link
G Ass1 argininosuccinate synthase 1 decreases expression EXP topiramate results in decreased expression of ASS1 mRNA CTD PMID:16979414 NCBI chr 3:10,327,411...10,375,847
Ensembl chr 3:10,327,414...10,375,826 		JBrowse link
G Avpr1a arginine vasopressin receptor 1A decreases expression EXP topiramate results in decreased expression of AVPR1A mRNA CTD PMID:16979414 NCBI chr 7:67,341,366...67,345,290
Ensembl chr 7:67,341,080...67,345,308 		JBrowse link
G Bdnf brain-derived neurotrophic factor multiple interactions EXP topiramate inhibits the reaction [3-nitropropionic acid results in decreased expression of BDNF protein] CTD PMID:29753867 NCBI chr 3:100,768,637...100,819,216
Ensembl chr 3:100,768,637...100,819,210 		JBrowse link
G Ca12 carbonic anhydrase 12 decreases activity ISO topiramate results in decreased activity of CA12 protein CTD PMID:21314129 NCBI chr 8:72,405,770...72,461,425
Ensembl chr 8:72,405,748...72,460,240 		JBrowse link
G Ca3 carbonic anhydrase 3 multiple interactions ISO topiramate binds to and results in decreased activity of CA3 protein CTD PMID:17826101 NCBI chr 2:88,126,519...88,136,063
Ensembl chr 2:88,126,667...88,135,410 		JBrowse link
G Calca calcitonin-related polypeptide alpha multiple interactions EXP Topiramate inhibits the reaction [Potassium Chloride results in increased secretion of CALCA protein]; Topiramate inhibits the reaction [Protons results in increased secretion of CALCA protein]; Topiramate inhibits the reaction [S-nitro-N-acetylpenicillamine results in increased secretion of CALCA protein] CTD PMID:16942474 NCBI chr 1:184,184,018...184,188,922
Ensembl chr 1:184,184,020...184,188,911 		JBrowse link
G Capn6 calpain 6 increases expression EXP topiramate results in increased expression of CAPN6 mRNA CTD PMID:16979414 NCBI chr  X:115,049,113...115,073,824
Ensembl chr  X:115,049,154...115,073,890 		JBrowse link
G Car1 carbonic anhydrase 1 multiple interactions ISO topiramate binds to and results in decreased activity of CA1 protein CTD PMID:17826101 NCBI chr 2:88,185,204...88,227,486
Ensembl chr 2:88,217,188...88,227,479 		JBrowse link
G Car2 carbonic anhydrase 2 multiple interactions
decreases activity		 ISO topiramate binds to and results in decreased activity of CA2 protein
topiramate results in decreased activity of CA2 protein		 CTD PMID:17826101 PMID:21314129 NCBI chr 2:88,097,740...88,112,868
Ensembl chr 2:88,097,720...88,113,029 		JBrowse link
G Casp3 caspase 3 affects expression
multiple interactions		 EXP topiramate affects the expression of CASP3 mRNA; topiramate affects the expression of CASP3 protein
topiramate inhibits the reaction [3-nitropropionic acid results in increased activity of CASP3 protein]		 CTD PMID:19148780 PMID:29753867 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204 		JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha decreases expression EXP topiramate results in decreased expression of CEBPA mRNA CTD PMID:16979414 NCBI chr 1:91,363,492...91,366,164
Ensembl chr 1:91,363,492...91,366,164 		JBrowse link
G Chka choline kinase alpha decreases expression EXP topiramate results in decreased expression of CHKA mRNA CTD PMID:16979414 NCBI chr 1:219,076,618...219,126,221
Ensembl chr 1:219,077,771...219,126,220 		JBrowse link
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit decreases expression EXP topiramate results in decreased expression of CHRNA7 mRNA CTD PMID:16979414 NCBI chr 1:123,897,341...124,039,263
Ensembl chr 1:123,899,657...124,039,196 		JBrowse link
G Cited2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 decreases expression EXP topiramate results in decreased expression of CITED2 mRNA CTD PMID:16979414 NCBI chr 1:12,823,363...12,825,806
Ensembl chr 1:12,823,363...12,825,786 		JBrowse link
G Cnr1 cannabinoid receptor 1 affects expression ISO topiramate affects the expression of CNR1 mRNA CTD PMID:22017514 NCBI chr 5:49,307,584...49,333,064
Ensembl chr 5:49,311,030...49,333,056 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions EXP topiramate inhibits the reaction [3-nitropropionic acid results in decreased phosphorylation of CREB1 protein] CTD PMID:29753867 NCBI chr 9:71,229,753...71,298,994
Ensembl chr 9:71,230,108...71,293,435 		JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 decreases activity ISO topiramate results in decreased activity of CYP17A1 protein CTD PMID:15730543 NCBI chr 1:266,422,127...266,429,947
Ensembl chr 1:266,422,132...266,428,239 		JBrowse link
G Cyp3a62 cytochrome P450, family 3, subfamily a, polypeptide 62 increases activity
increases expression		 ISO Topiramate results in increased activity of CYP3A4 protein
Topiramate results in increased expression of CYP3A4 mRNA; Topiramate results in increased expression of CYP3A4 protein		 CTD PMID:14636322 NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397 		JBrowse link
G Drd2 dopamine receptor D2 increases expression ISO topiramate results in increased expression of DRD2 mRNA CTD PMID:22489711 NCBI chr 8:53,678,777...53,743,643
Ensembl chr 8:53,678,777...53,743,642 		JBrowse link
G Dusp1 dual specificity phosphatase 1 increases expression EXP topiramate results in increased expression of DUSP1 mRNA CTD PMID:16979414 NCBI chr10:16,970,642...16,973,425
Ensembl chr10:16,970,626...16,973,418 		JBrowse link
G Fabp3 fatty acid binding protein 3 decreases expression EXP topiramate results in decreased expression of FABP3 mRNA CTD PMID:16979414 NCBI chr 5:148,528,854...148,535,597
Ensembl chr 5:148,528,725...148,535,565 		JBrowse link
G Gabra1 gamma-aminobutyric acid type A receptor subunit alpha 1 multiple interactions EXP topiramate inhibits the reaction [[gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein co-treated with GABRB2 protein co-treated with GABRG2 protein]] which results in increased transport of Chlorides] CTD PMID:11123204 NCBI chr10:27,310,718...27,371,802
Ensembl chr10:27,310,725...27,366,665 		JBrowse link
G Gabra2 gamma-aminobutyric acid type A receptor subunit alpha 2 multiple interactions EXP topiramate inhibits the reaction [[gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein co-treated with GABRB2 protein co-treated with GABRG2 protein]] which results in increased transport of Chlorides] CTD PMID:11123204 NCBI chr14:39,662,411...39,801,082
Ensembl chr14:39,661,968...39,798,302 		JBrowse link
G Gabra6 gamma-aminobutyric acid type A receptor subunit alpha6 multiple interactions EXP topiramate promotes the reaction [[gamma-Aminobutyric Acid results in increased activity of [GABRA6 protein co-treated with GABRB2 protein co-treated with GABRG2 protein]] which results in increased transport of Chlorides] CTD PMID:11123204 NCBI chr10:27,847,447...27,862,896
Ensembl chr10:27,847,439...27,862,868 		JBrowse link
G Gabrb2 gamma-aminobutyric acid type A receptor subunit beta 2 multiple interactions EXP topiramate inhibits the reaction [[gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein co-treated with GABRB2 protein co-treated with GABRG2 protein]] which results in increased transport of Chlorides]; topiramate inhibits the reaction [[gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein co-treated with GABRB2 protein co-treated with GABRG2 protein]] which results in increased transport of Chlorides]; topiramate promotes the reaction [[gamma-Aminobutyric Acid results in increased activity of [GABRA6 protein co-treated with GABRB2 protein co-treated with GABRG2 protein]] which results in increased transport of Chlorides] CTD PMID:11123204 NCBI chr10:27,973,694...28,193,072
Ensembl chr10:27,973,681...28,187,565 		JBrowse link
G Gabrg2 gamma-aminobutyric acid type A receptor subunit gamma 2 multiple interactions EXP topiramate inhibits the reaction [[gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein co-treated with GABRB2 protein co-treated with GABRG2 protein]] which results in increased transport of Chlorides]; topiramate inhibits the reaction [[gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein co-treated with GABRB2 protein co-treated with GABRG2 protein]] which results in increased transport of Chlorides]; topiramate promotes the reaction [[gamma-Aminobutyric Acid results in increased activity of [GABRA6 protein co-treated with GABRB2 protein co-treated with GABRG2 protein]] which results in increased transport of Chlorides] CTD PMID:11123204 NCBI chr10:27,090,913...27,179,786
Ensembl chr10:27,092,827...27,179,900 		JBrowse link
G Glul glutamate-ammonia ligase decreases activity ISO topiramate results in decreased activity of GLUL protein CTD PMID:10323596 NCBI chr13:71,331,052...71,340,207
Ensembl chr13:71,331,052...71,340,229 		JBrowse link
G Gnai2 G protein subunit alpha i2 decreases expression EXP topiramate results in decreased expression of GNAI2 mRNA CTD PMID:16979414 NCBI chr 8:116,370,730...116,391,337
Ensembl chr 8:116,370,744...116,391,307 		JBrowse link
G Got2 glutamic-oxaloacetic transaminase 2 increases expression EXP topiramate results in increased expression of GOT2 mRNA CTD PMID:16979414 NCBI chr19:9,587,637...9,613,323
Ensembl chr19:9,587,653...9,613,340 		JBrowse link
G Gpam glycerol-3-phosphate acyltransferase, mitochondrial decreases expression EXP topiramate results in decreased expression of GPAM mRNA CTD PMID:16979414 NCBI chr 1:275,843,823...275,906,880
Ensembl chr 1:275,846,819...275,906,686 		JBrowse link
G Gpd2 glycerol-3-phosphate dehydrogenase 2 increases expression EXP topiramate results in increased expression of GPD2 mRNA CTD PMID:16979414 NCBI chr 3:43,223,892...43,359,069
Ensembl chr 3:43,255,567...43,359,074 		JBrowse link
G Gria2 glutamate ionotropic receptor AMPA type subunit 2 multiple interactions EXP topiramate inhibits the reaction [3-nitropropionic acid results in decreased expression of GRIA2 mRNA] CTD PMID:29753867 NCBI chr 2:179,584,302...179,704,629
Ensembl chr 2:179,584,308...179,704,629 		JBrowse link
G Grik1 glutamate ionotropic receptor kainate type subunit 1 affects response to substance ISO GRIK1 gene SNP affects the susceptibility to topiramate CTD PMID:19331489 NCBI chr11:27,811,954...28,213,940
Ensembl chr11:27,811,957...27,971,359 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions EXP topiramate inhibits the reaction [3-nitropropionic acid results in decreased phosphorylation of GSK3B protein] CTD PMID:29753867 NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268 		JBrowse link
G Gtf2a2 general transcription factor 2A subunit 2 increases expression EXP topiramate results in increased expression of GTF2A2 mRNA CTD PMID:16979414 NCBI chr 8:76,422,341...76,435,587
Ensembl chr 8:76,422,359...76,435,473 		JBrowse link
G Gyg1 glycogenin 1 decreases expression EXP topiramate results in decreased expression of GYG1 mRNA CTD PMID:16979414 NCBI chr 2:104,916,734...104,958,219
Ensembl chr 2:104,916,738...104,958,034 		JBrowse link
G Hmgcs1 3-hydroxy-3-methylglutaryl-CoA synthase 1 increases expression EXP topiramate results in increased expression of HMGCS1 mRNA CTD PMID:16979414 NCBI chr 2:52,427,351...52,445,082
Ensembl chr 2:52,431,601...52,445,055 		JBrowse link
G Hsd3b2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 decreases activity ISO topiramate results in decreased activity of HSD3B2 protein CTD PMID:15730543 NCBI chr 2:200,712,895...200,722,429
Ensembl chr 2:202,341,422...202,350,929 		JBrowse link
G Idi1 isopentenyl-diphosphate delta isomerase 1 increases expression EXP topiramate results in increased expression of IDI1 mRNA CTD PMID:16979414 NCBI chr17:57,976,266...57,984,036
Ensembl chr17:57,976,268...57,984,036 		JBrowse link
G Ifi30 IFI30, lysosomal thiol reductase multiple interactions EXP [topiramate co-treated with Trinitrobenzenesulfonic Acid] results in decreased expression of IFI30 mRNA CTD PMID:21849664 NCBI chr16:20,426,566...20,430,772
Ensembl chr16:20,426,566...20,430,752 		JBrowse link
G Igf1 insulin-like growth factor 1 decreases expression EXP topiramate results in decreased expression of IGF1 mRNA CTD PMID:16979414 NCBI chr 7:28,412,123...28,491,815
Ensembl chr 7:28,412,198...28,486,609 		JBrowse link
G Itpr1 inositol 1,4,5-trisphosphate receptor, type 1 increases expression EXP topiramate results in increased expression of ITPR1 mRNA CTD PMID:16979414 NCBI chr 4:140,247,297...140,580,749
Ensembl chr 4:140,247,313...140,580,748 		JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO topiramate results in decreased activity of KCNH2 protein CTD PMID:15716081 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253 		JBrowse link
G Me1 malic enzyme 1 decreases expression EXP topiramate results in decreased expression of ME1 mRNA CTD PMID:16979414 NCBI chr 8:94,256,830...94,368,834
Ensembl chr 8:94,256,839...94,368,834 		JBrowse link
G Mvd mevalonate diphosphate decarboxylase increases expression EXP topiramate results in increased expression of MVD mRNA CTD PMID:16979414 NCBI chr19:55,258,910...55,268,933
Ensembl chr19:55,258,905...55,268,951 		JBrowse link
G Nos2 nitric oxide synthase 2 increases expression EXP topiramate results in increased expression of NOS2 protein CTD PMID:14511393 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190 		JBrowse link
G Npy neuropeptide Y increases expression EXP topiramate results in increased expression of NPY protein CTD PMID:17572454 NCBI chr 4:79,557,856...79,565,059
Ensembl chr 4:79,557,854...79,565,097
Ensembl chr 4:79,557,854...79,565,097 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity ISO topiramate results in increased activity of NR1I2 protein CTD PMID:14636322 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545 		JBrowse link
G Nr2f2 nuclear receptor subfamily 2, group F, member 2 decreases expression EXP topiramate results in decreased expression of NR2F2 mRNA CTD PMID:16979414 NCBI chr 1:131,447,671...131,465,749
Ensembl chr 1:131,448,447...131,460,473 		JBrowse link
G Nr4a2 nuclear receptor subfamily 4, group A, member 2 decreases expression EXP topiramate results in decreased expression of NR4A2 mRNA CTD PMID:16979414 NCBI chr 3:43,111,258...43,128,391
Ensembl chr 3:43,111,240...43,119,159 		JBrowse link
G Pde4b phosphodiesterase 4B decreases expression EXP topiramate results in decreased expression of PDE4B mRNA CTD PMID:16979414 NCBI chr 5:121,759,236...122,136,814
Ensembl chr 5:121,952,977...122,136,814 		JBrowse link
G Pdk4 pyruvate dehydrogenase kinase 4 decreases expression EXP topiramate results in decreased expression of PDK4 mRNA CTD PMID:16979414 NCBI chr 4:30,546,772...30,556,774
Ensembl chr 4:30,546,664...30,556,814 		JBrowse link
G Pick1 protein interacting with PRKCA 1 multiple interactions EXP topiramate inhibits the reaction [3-nitropropionic acid results in increased expression of PICK1 protein] CTD PMID:29753867 NCBI chr 7:120,465,472...120,484,824
Ensembl chr 7:120,465,130...120,484,840 		JBrowse link
G Plcd4 phospholipase C, delta 4 decreases expression EXP topiramate results in decreased expression of PLCD4 mRNA CTD PMID:16979414 NCBI chr 9:81,816,395...81,844,364
Ensembl chr 9:81,816,872...81,844,364 		JBrowse link
G Pld1 phospholipase D1 increases expression EXP topiramate results in increased expression of PLD1 mRNA CTD PMID:16979414 NCBI chr 2:113,651,967...113,849,403
Ensembl chr 2:113,652,348...113,849,403 		JBrowse link
G Ppp5c protein phosphatase 5, catalytic subunit increases expression EXP topiramate results in increased expression of PPP5C mRNA CTD PMID:16979414 NCBI chr 1:78,944,054...78,968,361
Ensembl chr 1:78,944,040...78,968,329 		JBrowse link
G Prkag1 protein kinase AMP-activated non-catalytic subunit gamma 1 decreases expression EXP topiramate results in decreased expression of PRKAG1 mRNA CTD PMID:16979414 NCBI chr 7:140,489,499...140,506,925
Ensembl chr 7:140,489,492...140,546,908 		JBrowse link
G Prkar2b protein kinase cAMP-dependent type II regulatory subunit beta decreases expression EXP topiramate results in decreased expression of PRKAR2B mRNA CTD PMID:16979414 NCBI chr 6:51,265,509...51,356,383
Ensembl chr 6:51,265,515...51,356,383 		JBrowse link
G RT1-DMb RT1 class II, locus DMb affects expression ISO topiramate affects the expression of HLA-DMB mRNA CTD PMID:25811541 NCBI chr20:3,945,383...3,952,838
Ensembl chr20:5,227,045...5,234,290
Ensembl chr20:5,227,045...5,234,290 		JBrowse link
G Scd stearoyl-CoA desaturase decreases expression EXP topiramate results in decreased expression of SCD1 mRNA CTD PMID:16979414 NCBI chr 1:264,159,966...264,173,061
Ensembl chr 1:264,160,129...264,172,729 		JBrowse link
G Slc16a1 solute carrier family 16 member 1 increases expression EXP topiramate results in increased expression of SLC16A1 mRNA CTD PMID:16979414 NCBI chr 2:207,108,552...207,129,352
Ensembl chr 2:207,108,552...207,128,554 		JBrowse link
G Slc37a4 solute carrier family 37 member 4 decreases expression EXP topiramate results in decreased expression of SLC37A4 mRNA CTD PMID:16979414 NCBI chr 8:48,716,914...48,723,024
Ensembl chr 8:48,716,939...48,723,024 		JBrowse link
G Slc47a1 solute carrier family 47 member 1 multiple interactions ISO topiramate affects the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr10:47,631,425...47,685,379
Ensembl chr10:47,632,192...47,666,921 		JBrowse link
G Slc6a6 solute carrier family 6 member 6 decreases expression EXP topiramate results in decreased expression of SLC6A6 mRNA CTD PMID:16979414 NCBI chr 4:123,638,619...123,713,469
Ensembl chr 4:123,642,210...123,713,464 		JBrowse link
G Slc7a1 solute carrier family 7 member 1 decreases expression EXP topiramate results in decreased expression of SLC7A1 mRNA CTD PMID:16979414 NCBI chr12:8,032,775...8,108,972
Ensembl chr12:8,032,809...8,108,972 		JBrowse link
G Sqle squalene epoxidase decreases expression EXP topiramate results in decreased expression of SQLE mRNA CTD PMID:16979414 NCBI chr 7:99,609,929...99,624,803
Ensembl chr 7:99,609,191...99,624,732 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 increases expression EXP topiramate results in increased expression of SREBF1 mRNA CTD PMID:16979414 NCBI chr10:46,570,996...46,593,021
Ensembl chr10:46,570,996...46,593,009 		JBrowse link
G Th tyrosine hydroxylase affects expression
increases expression		 ISO topiramate affects the expression of TH mRNA
topiramate results in increased expression of TH mRNA		 CTD PMID:22017514 PMID:22489711 NCBI chr 1:216,073,034...216,080,287
Ensembl chr 1:216,073,031...216,080,287 		JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 multiple interactions EXP topiramate inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of TRPV1 mRNA] CTD PMID:21849664 NCBI chr10:59,799,123...59,824,208
Ensembl chr10:59,799,123...59,824,679 		JBrowse link
G Ucp3 uncoupling protein 3 decreases expression EXP topiramate results in decreased expression of UCP3 mRNA CTD PMID:16979414 NCBI chr 1:165,482,912...165,495,895
Ensembl chr 1:165,482,155...165,496,206 		JBrowse link
G Ugt2b7 UDP glucuronosyltransferase family 2 member B7 affects response to substance ISO UGT2B7 gene SNP affects the susceptibility to topiramate CTD PMID:18686368 NCBI chr14:22,597,103...22,619,968 JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19770
    chemical entity 19770
      atom 19768
        nonmetal atom 19651
          oxygen atom 19354
            oxygen molecular entity 19354
              organooxygen compound 18877
                carbohydrates and carbohydrate derivatives 12259
                  carbohydrate 12259
                    monosaccharide 4187
                      ketose 403
                        ketohexose 368
                          3-keto-beta-D-galactose 0
                          L-xylo-3-hexulose 0
                          deoxyketohexose + 1
                          fructose + 304
                          ketohexose derivative + 80
                          psicose + 1
                          sorbose + 1
                          tagatose + 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19770
    subatomic particle 19768
      composite particle 19768
        hadron 19768
          baryon 19768
            nucleon 19768
              atomic nucleus 19768
                atom 19768
                  main group element atom 19662
                    p-block element atom 19662
                      carbon group element atom 19580
                        carbon atom 19571
                          organic molecular entity 19571
                            heteroorganic entity 19206
                              organochalcogen compound 18951
                                organooxygen compound 18877
                                  carbohydrates and carbohydrate derivatives 12259
                                    carbohydrate 12259
                                      monosaccharide 4187
                                        hexose 2315
                                          ketohexose 368
                                            3-keto-beta-D-galactose 0
                                            L-xylo-3-hexulose 0
                                            deoxyketohexose + 1
                                            fructose + 304
                                            ketohexose derivative + 80
                                            psicose + 1
                                            sorbose + 1
                                            tagatose + 1
paths to the root