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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:ketoaldehyde
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Accession:CHEBI:24960 term browser browse the term
Definition:Any compound that has an aldehydic and ketonic group in the same molecule.
Synonyms:related_synonym: ketoaldehydes
 alt_id: CHEBI:6124
 xref: KEGG:C01928



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methylglyoxal term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acp5 acid phosphatase 5, tartrate resistant multiple interactions
increases expression
ISO
EXP
[TNFSF11 protein co-treated with Pyruvaldehyde] affects the activity of ACP5 protein; [TNFSF11 protein co-treated with Pyruvaldehyde] results in decreased activity of ACP5 protein; bergenin inhibits the reaction [[TNFSF11 protein co-treated with Pyruvaldehyde] results in decreased activity of ACP5 protein]; MAPK8 protein affects the reaction [Pyruvaldehyde results in increased expression of ACP5 mRNA]
Pyruvaldehyde results in increased expression of ACP5 mRNA; Pyruvaldehyde results in increased expression of ACP5 protein
CTD PMID:30217477 PMID:31103701 PMID:31369791 NCBI chr 8:20,663,984...20,670,604
Ensembl chr 8:20,663,985...20,667,929
JBrowse link
G Acta2 actin alpha 2, smooth muscle increases expression
multiple interactions
ISO Pyruvaldehyde results in increased expression of ACTA2 protein
epigallocatechin gallate inhibits the reaction [Pyruvaldehyde results in increased expression of ACTA2 protein]
CTD PMID:22101032 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
JBrowse link
G Adgre1 adhesion G protein-coupled receptor E1 multiple interactions
increases expression
ISO epigallocatechin gallate inhibits the reaction [Pyruvaldehyde results in increased expression of ADGRE1 protein] CTD PMID:22101032 NCBI chr 9:2,242,476...2,398,000
Ensembl chr 9:2,242,474...2,398,000
JBrowse link
G Ager advanced glycosylation end product-specific receptor multiple interactions
increases expression
increases cleavage
ISO bergenin inhibits the reaction [Pyruvaldehyde results in increased cleavage of AGER protein]; epigallocatechin gallate inhibits the reaction [Pyruvaldehyde results in increased expression of AGER protein]; honokiol affects the reaction [Pyruvaldehyde results in increased cleavage of AGER protein]; pimagedine inhibits the reaction [Pyruvaldehyde results in increased cleavage of AGER protein]
Pyruvaldehyde results in increased expression of AGER mRNA
CTD PMID:22101032 PMID:26723916 PMID:29148590 PMID:30447388 NCBI chr20:4,148,150...4,151,361
Ensembl chr20:4,147,890...4,151,078
JBrowse link
G Agt angiotensinogen affects expression EXP Pyruvaldehyde affects the expression of AGT protein CTD PMID:24402234 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
JBrowse link
G Aifm2 apoptosis inducing factor, mitochondria associated 2 increases expression ISO Pyruvaldehyde results in increased expression of AIFM2 mRNA CTD PMID:30447388 NCBI chr20:29,654,283...29,679,239
Ensembl chr20:29,652,927...29,679,236
JBrowse link
G Akr1a1 aldo-keto reductase family 1 member A1 increases reduction ISO
EXP
AKR1A1 protein results in increased reduction of Pyruvaldehyde CTD PMID:10510318 PMID:29763686 NCBI chr 5:130,092,945...130,130,277
Ensembl chr 5:130,092,732...130,113,674
JBrowse link
G Akr1b1 aldo-keto reductase family 1 member B increases reduction ISO AKR1B1 protein results in increased reduction of Pyruvaldehyde CTD PMID:10510318 NCBI chr 4:62,932,033...62,946,126
Ensembl chr 4:62,932,031...62,946,157
JBrowse link
G Akr1b8 aldo-keto reductase family 1, member B8 multiple interactions EXP [AKR1B8 protein co-treated with NADP] affects the reduction of Pyruvaldehyde CTD PMID:18845131 NCBI chr 4:62,997,241...63,009,815 JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 increases expression ISO Pyruvaldehyde results in increased expression of AKR1C3 mRNA CTD PMID:25451587 NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873
JBrowse link
G Akr7a2 aldo-keto reductase family 7, member A2 decreases response to substance
increases expression
ISO AKR7A5 protein results in decreased susceptibility to Pyruvaldehyde
Pyruvaldehyde results in increased expression of AKR7A2 mRNA; Pyruvaldehyde results in increased expression of AKR7A2 protein
AKR7A2 protein results in decreased susceptibility to Pyruvaldehyde
CTD PMID:22001351 PMID:24590062 PMID:25451587 NCBI chr 5:151,552,375...151,560,914
Ensembl chr 5:151,552,343...151,560,909
JBrowse link
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation
multiple interactions
ISO Pyruvaldehyde results in decreased phosphorylation of AKT1 protein
resveratrol inhibits the reaction [Pyruvaldehyde results in decreased phosphorylation of AKT1 protein]
CTD PMID:22917016 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Akt2 AKT serine/threonine kinase 2 multiple interactions ISO [TNFSF11 protein co-treated with Pyruvaldehyde] results in increased expression of AKT2 mRNA; bergenin inhibits the reaction [[TNFSF11 protein co-treated with Pyruvaldehyde] results in increased expression of AKT2 mRNA] CTD PMID:31369791 NCBI chr 1:82,877,228...82,933,828
Ensembl chr 1:82,883,547...82,933,817
JBrowse link
G Alb albumin affects binding
increases oxidation
multiple interactions
ISO Pyruvaldehyde binds to ALB protein
Pyruvaldehyde results in increased oxidation of ALB protein
[ALB protein binds to Myristic Acid] promotes the reaction [Pyruvaldehyde results in increased oxidation of ALB protein]; [ALB protein binds to Oleic Acid] promotes the reaction [Pyruvaldehyde results in increased oxidation of ALB protein]; [ALB protein binds to Palmitic Acid] promotes the reaction [Pyruvaldehyde results in increased oxidation of ALB protein]; [ALB protein binds to stearic acid] promotes the reaction [Pyruvaldehyde results in increased oxidation of ALB protein]; [Pyruvaldehyde binds to ALB protein] which results in decreased metabolism of Prostaglandins; [Pyruvaldehyde results in increased oxidation of ALB protein] which results in decreased reduction of Dithionitrobenzoic Acid; Pyruvaldehyde inhibits the reaction [Warfarin binds to ALB protein]
CTD PMID:20934417 PMID:25451573 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
JBrowse link
G Aldh2 aldehyde dehydrogenase 2 family member multiple interactions EXP [Chloral Hydrate results in decreased activity of ALDH2 protein] which results in increased susceptibility to Pyruvaldehyde; [Disulfiram results in decreased activity of ALDH2 protein] which results in increased susceptibility to Pyruvaldehyde CTD PMID:21334317 NCBI chr12:34,949,549...34,982,527 JBrowse link
G Bad BCL2-associated agonist of cell death increases expression ISO Pyruvaldehyde results in increased expression of BAD mRNA CTD PMID:30447388 NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression
ISO naringenin inhibits the reaction [Pyruvaldehyde results in increased expression of BAX protein]; salvin inhibits the reaction [Pyruvaldehyde results in increased expression of BAX protein] CTD PMID:26577515 PMID:31254498 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression
ISO naringenin inhibits the reaction [Pyruvaldehyde results in decreased expression of BCL2 protein]; salvin inhibits the reaction [Pyruvaldehyde results in decreased expression of BCL2 protein]
Pyruvaldehyde results in decreased expression of BCL2 mRNA; Pyruvaldehyde results in decreased expression of BCL2 protein
CTD PMID:26577515 PMID:30447388 PMID:31254498 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Bdnf brain-derived neurotrophic factor increases expression
multiple interactions
ISO Pyruvaldehyde results in increased expression of BDNF protein
sulforaphane promotes the reaction [Pyruvaldehyde results in increased expression of BDNF protein]
CTD PMID:25933243 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
JBrowse link
G Car2 carbonic anhydrase 2 multiple interactions ISO [TNFSF11 protein co-treated with Pyruvaldehyde] affects the expression of CAR2 mRNA CTD PMID:30217477 NCBI chr 2:86,741,625...86,756,766
Ensembl chr 2:86,741,626...86,756,818
JBrowse link
G Casp3 caspase 3 increases cleavage
increases expression
increases activity
multiple interactions
ISO
EXP
Pyruvaldehyde results in increased cleavage of CASP3 protein
Pyruvaldehyde results in increased expression of CASP3 protein
Pyruvaldehyde results in increased activity of CASP3 protein
resveratrol inhibits the reaction [Pyruvaldehyde results in increased activity of CASP3 protein]
Pyruvaldehyde results in increased expression of CASP3 protein modified form
naringenin inhibits the reaction [Pyruvaldehyde results in increased activity of CASP3 protein]; salvin inhibits the reaction [Pyruvaldehyde results in increased expression of CASP3 protein]; sulforaphane inhibits the reaction [Pyruvaldehyde results in increased activity of CASP3 protein]; Telmisartan inhibits the reaction [Pyruvaldehyde results in increased cleavage of CASP3 protein]
CTD PMID:18565324 PMID:20621070 PMID:21793156 PMID:25933243 PMID:26577515 More... NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp9 caspase 9 multiple interactions
increases activity
increases expression
ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [salvin inhibits the reaction [Pyruvaldehyde results in increased expression of CASP9 protein]]; naringenin inhibits the reaction [Pyruvaldehyde results in increased activity of CASP9 protein]; salvin inhibits the reaction [Pyruvaldehyde results in increased expression of CASP9 protein] CTD PMID:26577515 PMID:31254498 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions
increases expression
ISO epigallocatechin gallate inhibits the reaction [Pyruvaldehyde results in increased expression of CCL2 protein] CTD PMID:22101032 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Clcn7 chloride voltage-gated channel 7 multiple interactions ISO [TNFSF11 protein co-treated with Pyruvaldehyde] affects the expression of CLCN7 mRNA CTD PMID:30217477 NCBI chr10:14,151,758...14,177,130
Ensembl chr10:14,151,758...14,177,130
JBrowse link
G Col3a1 collagen type III alpha 1 chain increases expression
multiple interactions
ISO Pyruvaldehyde results in increased expression of COL3A1 protein
epigallocatechin gallate inhibits the reaction [Pyruvaldehyde results in increased expression of COL3A1 protein]
CTD PMID:22101032 NCBI chr 9:47,374,611...47,410,547
Ensembl chr 9:47,374,593...47,410,547
JBrowse link
G Cp ceruloplasmin multiple interactions
decreases activity
ISO bathocuproine inhibits the reaction [Pyruvaldehyde promotes the reaction [CP protein binds to CP protein]]; Ditiocarb inhibits the reaction [Pyruvaldehyde promotes the reaction [CP protein binds to CP protein]]; formic acid inhibits the reaction [Pyruvaldehyde promotes the reaction [CP protein binds to CP protein]]; Pyruvaldehyde promotes the reaction [CP protein binds to CP protein]; Sodium Azide inhibits the reaction [Pyruvaldehyde promotes the reaction [CP protein binds to CP protein]]
Pyruvaldehyde results in decreased activity of CP protein
CTD PMID:16756764 NCBI chr 2:102,439,433...102,498,075
Ensembl chr 2:102,439,624...102,498,075
JBrowse link
G Ctsk cathepsin K increases expression
multiple interactions
EXP
ISO
Pyruvaldehyde results in increased expression of CTSK mRNA
MAPK8 protein affects the reaction [Pyruvaldehyde results in increased expression of CTSK mRNA]
CTD PMID:31103701 NCBI chr 2:183,058,586...183,069,551
Ensembl chr 2:183,058,569...183,069,550
JBrowse link
G Ctss cathepsin S decreases activity ISO Pyruvaldehyde results in decreased activity of CTSS protein CTD PMID:16671891 NCBI chr 2:183,089,192...183,114,483
Ensembl chr 2:183,086,437...183,114,483
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions ISO [CYP1A2 protein results in increased metabolism of and results in increased susceptibility to Meloxicam] which results in increased chemical synthesis of Pyruvaldehyde CTD PMID:33253783 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Fn1 fibronectin 1 multiple interactions
increases expression
EXP diphenyleneiodonium inhibits the reaction [Pyruvaldehyde results in increased expression of FN1 mRNA]; manumycin inhibits the reaction [Pyruvaldehyde results in increased expression of FN1 mRNA]; SB 203580 inhibits the reaction [Pyruvaldehyde results in increased expression of FN1 mRNA] CTD PMID:17635749 NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO [TNFSF11 protein co-treated with Pyruvaldehyde] affects the expression of FOS mRNA CTD PMID:30217477 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Gab2 GRB2-associated binding protein 2 multiple interactions ISO [TNFSF11 protein co-treated with Pyruvaldehyde] affects the expression of GAB2 mRNA CTD PMID:30217477 NCBI chr 1:151,429,844...151,625,708
Ensembl chr 1:151,429,695...151,625,031
JBrowse link
G Glo1 glyoxalase 1 affects response to substance
increases expression
multiple interactions
decreases activity
affects expression
decreases expression
ISO
EXP
GLO1 protein affects the susceptibility to Pyruvaldehyde
Pyruvaldehyde results in increased expression of GLO1 mRNA
magnolol inhibits the reaction [Pyruvaldehyde results in decreased activity of GLO1 protein]; pimagedine inhibits the reaction [Pyruvaldehyde results in decreased activity of GLO1 protein]
Pyruvaldehyde affects the expression of GLO1 protein
[TNFSF11 protein co-treated with Pyruvaldehyde] affects the expression of GLO1 protein; [TNFSF11 protein co-treated with Pyruvaldehyde] results in decreased activity of GLO1 protein; [TNFSF11 protein co-treated with Pyruvaldehyde] results in decreased expression of GLO1 protein; acetovanillone inhibits the reaction [Pyruvaldehyde results in decreased activity of GLO1 protein]; bergenin inhibits the reaction [[TNFSF11 protein co-treated with Pyruvaldehyde] results in decreased expression of GLO1 protein]; bergenin inhibits the reaction [Pyruvaldehyde results in decreased activity of GLO1 protein]; crocin inhibits the reaction [[TNFSF11 protein co-treated with Pyruvaldehyde] results in decreased activity of GLO1 protein]; honokiol inhibits the reaction [Pyruvaldehyde results in decreased activity of GLO1 protein]; Limonene inhibits the reaction [Pyruvaldehyde results in decreased activity of GLO1 protein]; pimagedine inhibits the reaction [Pyruvaldehyde results in decreased activity of GLO1 protein]
Pyruvaldehyde results in decreased expression of GLO1 protein
GLO1 protein affects the reaction [Pyruvaldehyde binds to HSPB1 protein]; NFE2L2 protein affects the reaction [Resveratrol affects the reaction [Pyruvaldehyde affects the expression of GLO1 protein]]; Resveratrol affects the reaction [Pyruvaldehyde affects the expression of GLO1 protein]; Rosiglitazone affects the reaction [Pyruvaldehyde affects the expression of GLO1 protein]; sulforaphane inhibits the reaction [Pyruvaldehyde results in decreased expression of GLO1 protein]
CTD PMID:20093988 PMID:22917016 PMID:25042521 PMID:25933243 PMID:26723916 More... NCBI chr20:8,663,617...8,681,661
Ensembl chr20:8,662,801...8,681,649
JBrowse link
G Gpx1 glutathione peroxidase 1 multiple interactions
increases expression
EXP magnolol promotes the reaction [Pyruvaldehyde results in increased expression of GPX1 mRNA]; pimagedine inhibits the reaction [Pyruvaldehyde results in increased expression of GPX1 mRNA] CTD PMID:28919305 NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024
JBrowse link
G Gsr glutathione-disulfide reductase decreases activity EXP Pyruvaldehyde results in decreased activity of GSR protein CTD PMID:24831520 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
JBrowse link
G Gsta5 glutathione S-transferase alpha 5 increases response to substance EXP GSTA5 protein results in increased susceptibility to Pyruvaldehyde CTD PMID:12076520 NCBI chr 8:79,105,561...79,117,472
Ensembl chr 8:79,105,661...79,117,472
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions ISO [Glucose co-treated with Oxygen deficiency] promotes the reaction [Pyruvaldehyde binds to and results in decreased activity of HIF1A protein]; Pyruvaldehyde binds to and results in decreased activity of HIF1A protein CTD PMID:18227068 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
decreases expression
affects expression
ISO Acetylcysteine affects the reaction [Pyruvaldehyde affects the expression of HMOX1 protein]; NFE2L2 protein affects the reaction [resveratrol affects the reaction [Pyruvaldehyde affects the expression of HMOX1 protein]]; resveratrol affects the reaction [Pyruvaldehyde affects the expression of HMOX1 protein]; rosiglitazone affects the reaction [Pyruvaldehyde affects the expression of HMOX1 protein]
bergenin inhibits the reaction [Pyruvaldehyde results in decreased expression of HMOX1 protein]; Limonene inhibits the reaction [Pyruvaldehyde results in decreased expression of HMOX1 protein]; pimagedine inhibits the reaction [Pyruvaldehyde results in decreased expression of HMOX1 protein]
CTD PMID:22917016 PMID:28986142 PMID:29148590 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Hras HRas proto-oncogene, GTPase increases activity EXP Pyruvaldehyde results in increased activity of HRAS protein CTD PMID:17635749 NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615
JBrowse link
G Hspb1 heat shock protein family B (small) member 1 affects binding
multiple interactions
ISO Pyruvaldehyde binds to HSPB1 protein
GLO1 protein affects the reaction [Pyruvaldehyde binds to HSPB1 protein]
CTD PMID:20093988 NCBI chr12:20,794,014...20,795,675
Ensembl chr12:20,794,028...20,795,743
JBrowse link
G Il1b interleukin 1 beta multiple interactions
decreases expression
increases expression
EXP magnolol inhibits the reaction [Pyruvaldehyde results in decreased expression of IL1B protein]; monascin inhibits the reaction [Pyruvaldehyde results in increased expression of IL1B protein]; pimagedine inhibits the reaction [Pyruvaldehyde results in decreased expression of IL1B protein]; PPARG mutant form inhibits the reaction [monascin inhibits the reaction [Pyruvaldehyde results in increased expression of IL1B protein]]; PPARG mutant form inhibits the reaction [Rosiglitazone inhibits the reaction [Pyruvaldehyde results in increased expression of IL1B protein]]; Rosiglitazone inhibits the reaction [Pyruvaldehyde results in increased expression of IL1B protein]
Pyruvaldehyde results in increased expression of IL1B mRNA; Pyruvaldehyde results in increased expression of IL1B protein
CTD PMID:23954466 PMID:28919305 PMID:31103701 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 affects expression
increases expression
increases secretion
multiple interactions
ISO
EXP
Pyruvaldehyde analog affects the expression of IL6 mRNA
Pyruvaldehyde results in increased expression of IL6 mRNA
Pyruvaldehyde results in increased secretion of IL6 protein
Pyruvaldehyde results in increased expression of IL6 protein
acetovanillone inhibits the reaction [Pyruvaldehyde results in increased expression of IL6 protein]; bergenin inhibits the reaction [Pyruvaldehyde results in increased expression of IL6 protein]; honokiol affects the reaction [Pyruvaldehyde results in increased expression of IL6 protein]; Limonene inhibits the reaction [Pyruvaldehyde results in increased secretion of IL6 protein]; pimagedine inhibits the reaction [Pyruvaldehyde results in increased expression of IL6 protein]
CTD PMID:20200221 PMID:25042521 PMID:26723916 PMID:28986142 PMID:29148590 More... NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Ins2 insulin 2 multiple interactions
decreases expression
EXP magnolol inhibits the reaction [Pyruvaldehyde results in decreased expression of INS2 mRNA] CTD PMID:28919305 NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775
JBrowse link
G Insr insulin receptor multiple interactions
decreases phosphorylation
ISO Acetylcysteine inhibits the reaction [Pyruvaldehyde results in decreased phosphorylation of INSR protein]; resveratrol inhibits the reaction [Pyruvaldehyde results in decreased phosphorylation of INSR protein]; rosiglitazone inhibits the reaction [Pyruvaldehyde results in decreased phosphorylation of INSR protein] CTD PMID:22917016 NCBI chr12:1,193,193...1,330,976
Ensembl chr12:1,197,100...1,330,883
JBrowse link
G Irs1 insulin receptor substrate 1 decreases phosphorylation EXP Pyruvaldehyde results in decreased phosphorylation of IRS1 protein CTD PMID:23954466 NCBI chr 9:83,552,964...83,605,797
Ensembl chr 9:83,548,944...83,606,122
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation
multiple interactions
ISO Pyruvaldehyde results in increased phosphorylation of MAPK1 protein
sulforaphane inhibits the reaction [Pyruvaldehyde results in increased phosphorylation of MAPK1 protein]
CTD PMID:25933243 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation
ISO sulforaphane inhibits the reaction [Pyruvaldehyde results in increased phosphorylation of MAPK3 protein]
[TNFSF11 protein co-treated with Pyruvaldehyde] affects the expression of MAPK3 mRNA; [TNFSF11 protein co-treated with Pyruvaldehyde] results in increased expression of MAPK3 mRNA; bergenin inhibits the reaction [[TNFSF11 protein co-treated with Pyruvaldehyde] results in increased expression of MAPK3 mRNA]
CTD PMID:25933243 PMID:30217477 PMID:31369791 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases phosphorylation
multiple interactions
ISO Pyruvaldehyde results in increased phosphorylation of MAPK8 protein
MAPK8 protein affects the reaction [Pyruvaldehyde results in increased expression of ACP5 mRNA]; MAPK8 protein affects the reaction [Pyruvaldehyde results in increased expression of CTSK mRNA]; MAPK8 protein affects the reaction [Pyruvaldehyde results in increased expression of OSCAR mRNA]
sulforaphane inhibits the reaction [Pyruvaldehyde results in increased phosphorylation of MAPK8 protein]
CTD PMID:25933243 PMID:31103701 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 increases phosphorylation
multiple interactions
ISO Pyruvaldehyde results in increased phosphorylation of MAPK9 protein
sulforaphane inhibits the reaction [Pyruvaldehyde results in increased phosphorylation of MAPK9 protein]
CTD PMID:25933243 NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178
JBrowse link
G Mapt microtubule-associated protein tau multiple interactions ISO Pyruvaldehyde promotes the reaction [MAPT protein binds to MAPT protein] CTD PMID:17082178 NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129
JBrowse link
G Mmp9 matrix metallopeptidase 9 increases expression
multiple interactions
ISO Pyruvaldehyde results in increased expression of MMP9 protein
[TNFSF11 protein co-treated with Pyruvaldehyde co-treated with bergenin] results in decreased expression of MMP9 mRNA
CTD PMID:28760545 PMID:31369791 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Nfatc1 nuclear factor of activated T-cells 1 multiple interactions ISO [TNFSF11 protein co-treated with Pyruvaldehyde] affects the expression of NFATC1 mRNA CTD PMID:30217477 NCBI chr18:74,046,421...74,156,041
Ensembl chr18:74,046,904...74,156,028
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions
affects expression
decreases expression
affects response to substance
decreases phosphorylation
affects localization
ISO
EXP
[resveratrol results in increased activity of NFE2L2 protein] which results in decreased susceptibility to Pyruvaldehyde; NFE2L2 protein affects the reaction [resveratrol affects the reaction [Pyruvaldehyde affects the expression of GLO1 protein]]; NFE2L2 protein affects the reaction [resveratrol affects the reaction [Pyruvaldehyde affects the expression of HMOX1 protein]]; NFE2L2 protein affects the reaction [resveratrol inhibits the reaction [Pyruvaldehyde affects the localization of SLC2A2 protein]]; NFE2L2 protein affects the reaction [resveratrol inhibits the reaction [Pyruvaldehyde results in decreased uptake of 2-(N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)-2-deoxyglucose]]; NFE2L2 protein affects the reaction [resveratrol inhibits the reaction [Pyruvaldehyde results in increased expression of PTPN1 protein]]; resveratrol inhibits the reaction [Pyruvaldehyde results in decreased phosphorylation of NFE2L2 protein]
bergenin affects the reaction [Pyruvaldehyde affects the expression of NFE2L2 protein]
Pyruvaldehyde results in decreased expression of NFE2L2 mRNA
NFE2L2 protein affects the susceptibility to Pyruvaldehyde
Pyruvaldehyde affects the localization of NFE2L2 protein
CTD PMID:22917016 PMID:23331247 PMID:23954466 PMID:25451587 PMID:28263721 More... NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nos2 nitric oxide synthase 2 affects response to substance
multiple interactions
increases expression
EXP NOS2 protein affects the susceptibility to Pyruvaldehyde
pyrrolidine dithiocarbamic acid inhibits the reaction [Pyruvaldehyde results in increased expression of NOS2 protein]
CTD PMID:20621070 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression ISO Pyruvaldehyde results in increased expression of NQO1 mRNA CTD PMID:25451587 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Nrf1 nuclear respiratory factor 1 multiple interactions
increases expression
EXP monascin inhibits the reaction [Pyruvaldehyde results in increased expression of NRF1 mRNA]; Silymarin inhibits the reaction [Pyruvaldehyde results in increased expression of NRF1 mRNA]; Tretinoin inhibits the reaction [monascin inhibits the reaction [Pyruvaldehyde results in increased expression of NRF1 mRNA]] CTD PMID:23331247 NCBI chr 4:58,664,932...58,772,328
Ensembl chr 4:58,664,957...58,825,328
JBrowse link
G Ntrk2 neurotrophic receptor tyrosine kinase 2 decreases expression
multiple interactions
ISO Pyruvaldehyde results in decreased expression of NTRK2 protein
sulforaphane inhibits the reaction [Pyruvaldehyde results in decreased expression of NTRK2 protein]
CTD PMID:25933243 NCBI chr17:5,558,992...5,870,299
Ensembl chr17:5,559,043...5,869,136
JBrowse link
G Oscar osteoclast associated Ig-like receptor increases expression
multiple interactions
ISO
EXP
Pyruvaldehyde results in increased expression of OSCAR mRNA
MAPK8 protein affects the reaction [Pyruvaldehyde results in increased expression of OSCAR mRNA]
CTD PMID:31103701 NCBI chr 1:65,607,214...65,615,395
Ensembl chr 1:65,607,410...65,613,758
JBrowse link
G Ostm1 osteoclastogenesis associated transmembrane protein 1 multiple interactions ISO [TNFSF11 protein co-treated with Pyruvaldehyde] affects the expression of OSTM1 mRNA; [TNFSF11 protein co-treated with Pyruvaldehyde] results in increased expression of OSTM1 mRNA; bergenin inhibits the reaction [[TNFSF11 protein co-treated with Pyruvaldehyde] results in increased expression of OSTM1 mRNA] CTD PMID:30217477 PMID:31369791 NCBI chr20:46,071,657...46,187,049
Ensembl chr20:46,153,075...46,187,023
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases cleavage
ISO naringenin inhibits the reaction [Pyruvaldehyde results in increased cleavage of PARP1 protein] CTD PMID:31254498 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Pdx1 pancreatic and duodenal homeobox 1 multiple interactions EXP [magnolol co-treated with Pyruvaldehyde] results in increased expression of PDX1 mRNA CTD PMID:28919305 NCBI chr12:7,757,865...7,763,064
Ensembl chr12:7,757,865...7,763,064
JBrowse link
G Pecam1 platelet and endothelial cell adhesion molecule 1 multiple interactions
increases expression
ISO epigallocatechin gallate inhibits the reaction [Pyruvaldehyde results in increased expression of PECAM1 protein] CTD PMID:22101032 NCBI chr10:91,590,521...91,652,279
Ensembl chr10:91,590,521...91,652,116
JBrowse link
G Pon1 paraoxonase 1 multiple interactions
decreases activity
ISO Pyruvaldehyde inhibits the reaction [PON1 protein results in increased hydrolysis of Paraoxon]; Pyruvaldehyde inhibits the reaction [PON1 protein results in increased hydrolysis of phenylacetic acid]
Pyruvaldehyde results in decreased activity of PON1 protein
CTD PMID:15375178 NCBI chr 4:33,294,737...33,325,759
Ensembl chr 4:33,294,722...33,321,360
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions EXP PPARG mutant form inhibits the reaction [monascin inhibits the reaction [Pyruvaldehyde results in decreased uptake of 2-(N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)-2-deoxyglucose]]; PPARG mutant form inhibits the reaction [monascin inhibits the reaction [Pyruvaldehyde results in increased expression of IL1B protein]]; PPARG mutant form inhibits the reaction [monascin inhibits the reaction [Pyruvaldehyde results in increased expression of TNF protein]]; PPARG mutant form inhibits the reaction [Rosiglitazone inhibits the reaction [Pyruvaldehyde results in decreased uptake of 2-(N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)-2-deoxyglucose]]; PPARG mutant form inhibits the reaction [Rosiglitazone inhibits the reaction [Pyruvaldehyde results in increased expression of IL1B protein]]; PPARG mutant form inhibits the reaction [Rosiglitazone inhibits the reaction [Pyruvaldehyde results in increased expression of TNF protein]] CTD PMID:23954466 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha multiple interactions ISO
EXP
[Limonene co-treated with Pyruvaldehyde] results in increased expression of PPARGC1A protein; [Pyruvaldehyde co-treated with honokiol] results in increased expression of PPARGC1A protein; [Pyruvaldehyde co-treated with pimagedine] results in increased expression of PPARGC1A protein
[magnolol co-treated with Pyruvaldehyde] results in increased expression of PPARGC1A protein; [pimagedine co-treated with Pyruvaldehyde] results in increased expression of PPARGC1A protein
CTD PMID:26723916 PMID:28919305 PMID:28986142 NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656
JBrowse link
G Ptpn1 protein tyrosine phosphatase, non-receptor type 1 multiple interactions
increases expression
ISO Acetylcysteine inhibits the reaction [Pyruvaldehyde results in increased expression of PTPN1 protein]; NFE2L2 protein affects the reaction [resveratrol inhibits the reaction [Pyruvaldehyde results in increased expression of PTPN1 protein]]; rosiglitazone inhibits the reaction [Pyruvaldehyde results in increased expression of PTPN1 protein] CTD PMID:22917016 NCBI chr 3:156,638,811...156,687,503
Ensembl chr 3:156,638,769...156,687,504
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
increases activity
affects localization
EXP pyrrolidine dithiocarbamic acid inhibits the reaction [Pyruvaldehyde affects the localization of RELA protein]; pyrrolidine dithiocarbamic acid inhibits the reaction [Pyruvaldehyde results in increased activity of RELA protein] CTD PMID:20621070 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Sirt1 sirtuin 1 multiple interactions EXP [magnolol co-treated with Pyruvaldehyde] results in increased expression of SIRT1 protein; [pimagedine co-treated with Pyruvaldehyde] results in increased expression of SIRT1 protein CTD PMID:28919305 NCBI chr20:25,307,143...25,329,260
Ensembl chr20:25,306,917...25,329,260
JBrowse link
G Slc2a2 solute carrier family 2 member 2 multiple interactions
affects localization
ISO Acetylcysteine inhibits the reaction [Pyruvaldehyde affects the localization of SLC2A2 protein]; NFE2L2 protein affects the reaction [resveratrol inhibits the reaction [Pyruvaldehyde affects the localization of SLC2A2 protein]]; resveratrol inhibits the reaction [Pyruvaldehyde affects the localization of SLC2A2 protein]; rosiglitazone inhibits the reaction [Pyruvaldehyde affects the localization of SLC2A2 protein] CTD PMID:22917016 NCBI chr 2:111,609,798...111,639,930
Ensembl chr 2:111,611,774...111,639,933
JBrowse link
G Sod1 superoxide dismutase 1 decreases expression ISO Pyruvaldehyde results in decreased expression of SOD1 mRNA CTD PMID:30447388 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
JBrowse link
G Sod2 superoxide dismutase 2 decreases expression
increases expression
ISO Pyruvaldehyde results in decreased expression of SOD2 mRNA
Pyruvaldehyde results in increased expression of SOD2 mRNA
CTD PMID:30447388 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
JBrowse link
G Tcirg1 T-cell immune regulator 1, ATPase H+ transporting V0 subunit A3 multiple interactions ISO [TNFSF11 protein co-treated with Pyruvaldehyde] affects the expression of TCIRG1 mRNA CTD PMID:30217477 NCBI chr 1:201,127,034...201,138,787
Ensembl chr 1:201,127,034...201,138,742
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions
increases expression
EXP
ISO
diphenyleneiodonium inhibits the reaction [Pyruvaldehyde results in increased expression of TGFB1 mRNA]; diphenyleneiodonium inhibits the reaction [Pyruvaldehyde results in increased expression of TGFB1 protein]
epigallocatechin gallate inhibits the reaction [Pyruvaldehyde results in increased expression of TGFB1 protein]
Pyruvaldehyde results in increased expression of TGFB1 mRNA; Pyruvaldehyde results in increased expression of TGFB1 protein
CTD PMID:17635749 PMID:22101032 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases secretion
increases expression
EXP
ISO
monascin inhibits the reaction [Pyruvaldehyde results in increased expression of TNF protein]; PPARG mutant form inhibits the reaction [monascin inhibits the reaction [Pyruvaldehyde results in increased expression of TNF protein]]; PPARG mutant form inhibits the reaction [rosiglitazone inhibits the reaction [Pyruvaldehyde results in increased expression of TNF protein]]; rosiglitazone inhibits the reaction [Pyruvaldehyde results in increased expression of TNF protein]
Pyruvaldehyde results in increased secretion of TNF protein
acetovanillone inhibits the reaction [Pyruvaldehyde results in increased expression of TNF protein]; honokiol inhibits the reaction [Pyruvaldehyde results in increased expression of TNF protein]; limonene inhibits the reaction [Pyruvaldehyde results in increased secretion of TNF protein]; pimagedine inhibits the reaction [Pyruvaldehyde results in increased expression of TNF protein]
CTD PMID:23954466 PMID:25042521 PMID:26723916 PMID:28986142 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tnfsf11 TNF superfamily member 11 multiple interactions ISO [TNFSF11 protein co-treated with Pyruvaldehyde co-treated with bergenin] results in decreased expression of MMP9 mRNA; [TNFSF11 protein co-treated with Pyruvaldehyde] affects the activity of ACP5 protein; [TNFSF11 protein co-treated with Pyruvaldehyde] affects the expression of CAR2 mRNA; [TNFSF11 protein co-treated with Pyruvaldehyde] affects the expression of CLCN7 mRNA; [TNFSF11 protein co-treated with Pyruvaldehyde] affects the expression of FOS mRNA; [TNFSF11 protein co-treated with Pyruvaldehyde] affects the expression of GAB2 mRNA; [TNFSF11 protein co-treated with Pyruvaldehyde] affects the expression of GLO1 protein; [TNFSF11 protein co-treated with Pyruvaldehyde] affects the expression of MAPK3 mRNA; [TNFSF11 protein co-treated with Pyruvaldehyde] affects the expression of NFATC1 mRNA; [TNFSF11 protein co-treated with Pyruvaldehyde] affects the expression of OSTM1 mRNA; [TNFSF11 protein co-treated with Pyruvaldehyde] affects the expression of TCIRG1 mRNA; [TNFSF11 protein co-treated with Pyruvaldehyde] affects the expression of TRAF6 mRNA; [TNFSF11 protein co-treated with Pyruvaldehyde] results in decreased activity of ACP5 protein; [TNFSF11 protein co-treated with Pyruvaldehyde] results in decreased activity of GLO1 protein; [TNFSF11 protein co-treated with Pyruvaldehyde] results in decreased expression of GLO1 protein; [TNFSF11 protein co-treated with Pyruvaldehyde] results in increased expression of AKT2 mRNA; [TNFSF11 protein co-treated with Pyruvaldehyde] results in increased expression of MAPK3 mRNA; [TNFSF11 protein co-treated with Pyruvaldehyde] results in increased expression of OSTM1 mRNA; bergenin inhibits the reaction [[TNFSF11 protein co-treated with Pyruvaldehyde] results in decreased activity of ACP5 protein]; bergenin inhibits the reaction [[TNFSF11 protein co-treated with Pyruvaldehyde] results in decreased expression of GLO1 protein]; bergenin inhibits the reaction [[TNFSF11 protein co-treated with Pyruvaldehyde] results in increased expression of AKT2 mRNA]; bergenin inhibits the reaction [[TNFSF11 protein co-treated with Pyruvaldehyde] results in increased expression of MAPK3 mRNA]; bergenin inhibits the reaction [[TNFSF11 protein co-treated with Pyruvaldehyde] results in increased expression of OSTM1 mRNA]; crocin inhibits the reaction [[TNFSF11 protein co-treated with Pyruvaldehyde] results in decreased activity of GLO1 protein] CTD PMID:30217477 PMID:30580027 PMID:31369791 NCBI chr15:53,674,990...53,705,171
Ensembl chr15:53,673,877...53,705,445
JBrowse link
G Traf6 TNF receptor associated factor 6 multiple interactions ISO [TNFSF11 protein co-treated with Pyruvaldehyde] affects the expression of TRAF6 mRNA CTD PMID:30217477 NCBI chr 3:87,963,517...87,988,316
Ensembl chr 3:87,963,514...87,983,507
JBrowse link
G Trpa1 transient receptor potential cation channel, subfamily A, member 1 multiple interactions
increases activity
ISO [Pyruvaldehyde results in increased activity of TRPA1 protein] which results in increased transport of Calcium CTD PMID:22863862 NCBI chr 5:4,379,999...4,433,243
Ensembl chr 5:4,379,999...4,433,570
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions
increases expression
EXP Silymarin inhibits the reaction [Pyruvaldehyde results in increased expression of VCAM1 mRNA] CTD PMID:23331247 NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions
increases expression
ISO epigallocatechin gallate inhibits the reaction [Pyruvaldehyde results in increased expression of VEGFA protein] CTD PMID:22101032 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19795
    role 19746
      application 19492
        solvent 16631
          formic acid 8819
            formyl group 8792
              aldehyde 8792
                ketoaldehyde 79
                  (1S,2S,3S)-3-methoxy-2-[(2E)-6-methylhept-2-en-2-yl]-4-oxocyclohexanecarbaldehyde + 0
                  (S)-3-acetyloctanal 0
                  2-oxo aldehyde + 79
                  3-oxo aldehyde + 0
                  4-oxopentanal 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19795
    subatomic particle 19794
      composite particle 19794
        hadron 19794
          baryon 19794
            nucleon 19794
              atomic nucleus 19794
                atom 19794
                  main group element atom 19693
                    p-block element atom 19693
                      carbon group element atom 19614
                        carbon atom 19604
                          organic molecular entity 19604
                            organic group 18713
                              organic divalent group 18697
                                organodiyl group 18697
                                  carbonyl group 18646
                                    carbonyl compound 18646
                                      carboxylic acid 18341
                                        carboacyl group 17466
                                          univalent carboacyl group 17466
                                            formyl group 8792
                                              aldehyde 8792
                                                ketoaldehyde 79
                                                  (1S,2S,3S)-3-methoxy-2-[(2E)-6-methylhept-2-en-2-yl]-4-oxocyclohexanecarbaldehyde + 0
                                                  (S)-3-acetyloctanal 0
                                                  2-oxo aldehyde + 79
                                                  3-oxo aldehyde + 0
                                                  4-oxopentanal 0
paths to the root