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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:kanamycins
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Accession:CHEBI:24951 term browser browse the term


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amikacin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc3 ATP binding cassette subfamily C member 3 decreases expression EXP Amikacin results in decreased expression of ABCC3 mRNA CTD PMID:27765674 NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595 		JBrowse link
G Abcc4 ATP binding cassette subfamily C member 4 decreases expression EXP Amikacin results in decreased expression of ABCC4 mRNA CTD PMID:27765674 NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283 		JBrowse link
G Casr calcium-sensing receptor increases activity ISO Amikacin results in increased activity of CASR protein CTD PMID:19884751 NCBI chr11:64,235,251...64,304,811
Ensembl chr11:64,235,251...64,304,811 		JBrowse link
G Cat catalase decreases activity
multiple interactions		 ISO Amikacin results in decreased activity of CAT protein
cefepime inhibits the reaction [Amikacin results in decreased activity of CAT protein]		 CTD PMID:18781908 PMID:23416261 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Il1a interleukin 1 alpha decreases expression ISO Amikacin results in decreased expression of IL1A mRNA CTD PMID:32816093 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822 		JBrowse link
G Il1b interleukin 1 beta decreases expression ISO Amikacin results in decreased expression of IL1B mRNA CTD PMID:32816093 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il24 interleukin 24 decreases expression ISO Amikacin results in decreased expression of IL24 mRNA CTD PMID:32816093 NCBI chr13:42,353,089...42,358,487
Ensembl chr13:42,353,090...42,358,487 		JBrowse link
G Pgd phosphogluconate dehydrogenase decreases activity EXP Amikacin results in decreased activity of PGD protein CTD PMID:15558954 NCBI chr 5:159,582,746...159,598,945
Ensembl chr 5:159,561,271...159,742,778 		JBrowse link
G Pid1 phosphotyrosine interaction domain containing 1 increases expression ISO Amikacin results in increased expression of PID1 mRNA CTD PMID:32816093 NCBI chr 9:85,284,335...85,503,035
Ensembl chr 9:85,284,335...85,503,044 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases expression ISO Amikacin results in decreased expression of PTGS2 mRNA CTD PMID:32816093 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Slc7a11 solute carrier family 7 member 11 decreases expression ISO Amikacin results in decreased expression of SLC7A11 mRNA CTD PMID:32816093 NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536 		JBrowse link
G Slpi secretory leukocyte peptidase inhibitor increases expression ISO Amikacin results in increased expression of SLPI mRNA CTD PMID:32816093 NCBI chr 3:153,082,208...153,084,457
Ensembl chr 3:153,082,369...153,084,453 		JBrowse link
G Tyr tyrosinase decreases activity ISO Amikacin results in decreased activity of TYR protein CTD PMID:23416261 NCBI chr 1:141,115,036...141,210,207
Ensembl chr 1:141,115,036...141,210,207 		JBrowse link
kanamycin A term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd86 CD86 molecule increases expression ISO Kanamycin results in increased expression of CD86 protein CTD PMID:19665512 NCBI chr11:64,142,193...64,200,816
Ensembl chr11:64,163,828...64,200,818 		JBrowse link
G Diaph1 diaphanous-related formin 1 multiple interactions
decreases expression		 ISO Kanamycin inhibits the reaction [DIAPH1 binds to RHOA]
Kanamycin results in decreased expression of DIAPH1 protein		 CTD PMID:16521128 NCBI chr18:29,669,659...29,769,070
Ensembl chr18:29,669,659...29,769,172 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit increases phosphorylation EXP Kanamycin results in increased phosphorylation of JUN protein CTD PMID:17570507 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases phosphorylation EXP Kanamycin results in increased phosphorylation of MAPK8 protein CTD PMID:17570507 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Ncf2 neutrophil cytosolic factor 2 multiple interactions ISO Kanamycin promotes the reaction [RAC1 binds to NCF2] CTD PMID:16521128 NCBI chr13:64,955,622...64,986,144
Ensembl chr13:64,955,503...64,986,277 		JBrowse link
G Prdx3 peroxiredoxin 3 multiple interactions
increases expression		 ISO 2,3-dihydroxybenzoic acid promotes the reaction [Kanamycin results in increased expression of PRDX3 protein]
Kanamycin results in increased expression of PRDX3 mRNA; Kanamycin results in increased expression of PRDX3 protein		 CTD PMID:23626763 NCBI chr 1:260,001,642...260,014,064
Ensembl chr 1:260,001,637...260,014,111 		JBrowse link
G Rac1 Rac family small GTPase 1 multiple interactions ISO Kanamycin promotes the reaction [RAC1 binds to NCF2] CTD PMID:16521128 NCBI chr12:11,037,028...11,057,251
Ensembl chr12:11,036,698...11,057,251 		JBrowse link
G Rhoa ras homolog family member A multiple interactions
increases expression
decreases expression		 ISO Kanamycin inhibits the reaction [DIAPH1 binds to RHOA]
Kanamycin results in increased expression of RHOA protein
Kanamycin results in decreased expression of RHOA protein		 CTD PMID:16521128 NCBI chr 8:108,991,926...109,025,746
Ensembl chr 8:108,991,954...109,025,746 		JBrowse link
G Slc1a3 solute carrier family 1 member 3 affects response to substance ISO SLC1A3 affects the susceptibility to Kanamycin CTD PMID:15862894 NCBI chr 2:57,755,495...57,830,605
Ensembl chr 2:57,755,497...57,830,605 		JBrowse link
tobramycin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Anpep alanyl aminopeptidase, membrane decreases activity EXP Tobramycin results in decreased activity of ANPEP protein CTD PMID:6653171 NCBI chr 1:133,767,332...133,810,137
Ensembl chr 1:133,767,332...133,785,789 		JBrowse link
G B2m beta-2 microglobulin increases expression ISO Tobramycin results in increased expression of B2M protein CTD PMID:2218653 NCBI chr 3:109,095,740...109,101,764
Ensembl chr 3:109,095,729...109,101,766 		JBrowse link
G Ctsb cathepsin B affects activity EXP Tobramycin affects the activity of CTSB protein CTD PMID:6653171 NCBI chr15:37,389,636...37,410,508
Ensembl chr15:37,389,629...37,410,500 		JBrowse link
G Elane elastase, neutrophil expressed multiple interactions ISO [Copper binds to Tobramycin] which results in decreased activity of ELANE protein CTD PMID:23072509 NCBI chr 7:9,817,251...9,819,174
Ensembl chr 7:9,817,252...9,819,100 		JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha increases expression ISO Tobramycin results in increased expression of GADD45A mRNA CTD PMID:26260164 NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO Tobramycin results in increased expression of HMOX1 mRNA; Tobramycin results in increased expression of HMOX1 protein CTD PMID:26260164 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Muc5ac mucin 5AC, oligomeric mucus/gel-forming multiple interactions ISO Tobramycin inhibits the reaction [Lipopolysaccharides results in increased expression of MUC5AC mRNA]; Tobramycin inhibits the reaction [Lipopolysaccharides results in increased secretion of MUC5AC protein] CTD PMID:21414310 NCBI chr 1:196,864,336...196,896,475
Ensembl chr 1:196,864,336...196,896,475 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO [Copper binds to Tobramycin] inhibits the reaction [TNF protein results in increased abundance of Reactive Oxygen Species] CTD PMID:23072509 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Zfp36 zinc finger protein 36 increases expression ISO Tobramycin results in increased expression of ZFP36 mRNA CTD PMID:26260164 NCBI chr 1:83,669,084...83,671,564
Ensembl chr 1:83,669,084...83,671,564 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19932
    role 19904
      biological role 19902
        antimicrobial agent 18269
          carbohydrate-containing antibiotic 7551
            aminoglycoside antibiotic 7539
              kanamycins 31
                2''-nucleotidylkanamycin 0
                2'-oxokanamycin 0
                3''-deamino-3''-hydroxykanamycin B 0
                3''-deamino-3''-hydroxykanamycin C 0
                3''-deamino-3''-hydroxykanamycin X 0
                acetylkanamycin + 0
                arbekacin + 0
                carbamoylkanamycin + 0
                dibekacin + 0
                kanamycin 0
                kanamycin A + 22
                kanamycin B + 9
                kanamycin C + 0
                kanamycin D + 0
                kanamycin X + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19932
    subatomic particle 19930
      composite particle 19930
        hadron 19930
          baryon 19930
            nucleon 19930
              atomic nucleus 19930
                atom 19930
                  main group element atom 19876
                    p-block element atom 19876
                      carbon group element atom 19816
                        carbon atom 19812
                          organic molecular entity 19812
                            heteroorganic entity 19559
                              organochalcogen compound 19317
                                organooxygen compound 19231
                                  carbohydrates and carbohydrate derivatives 15298
                                    carbohydrate 15298
                                      carbohydrate derivative 14308
                                        glycosyl compound 13064
                                          glycoside 11847
                                            aminoglycoside 11273
                                              aminoglycoside antibiotic 7539
                                                kanamycins 31
                                                  2''-nucleotidylkanamycin 0
                                                  2'-oxokanamycin 0
                                                  3''-deamino-3''-hydroxykanamycin B 0
                                                  3''-deamino-3''-hydroxykanamycin C 0
                                                  3''-deamino-3''-hydroxykanamycin X 0
                                                  acetylkanamycin + 0
                                                  arbekacin + 0
                                                  carbamoylkanamycin + 0
                                                  dibekacin + 0
                                                  kanamycin 0
                                                  kanamycin A + 22
                                                  kanamycin B + 9
                                                  kanamycin C + 0
                                                  kanamycin D + 0
                                                  kanamycin X + 0
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