ion - Ontology Report - Rat Genome Database

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CHEBI ONTOLOGY - ANNOTATIONS

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	ion	go back to main search page
Accession:	CHEBI:24870	browse the term
Definition:	A molecular entity having a net electric charge.
Synonyms:	related_synonym:	Ionen; iones; ions

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Rat (16709) Mouse (17696) Human (18767) Chinchilla (0) Bonobo (0) Dog (32) Squirrel (0) Pig (168) Green Monkey (1) Naked Mole-rat (0) All
Genes (168)

(R)-carnitine

term browser

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Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

solute carrier family 22 member 5

increases uptake

SLC22A5 protein results in increased uptake of Carnitine

NCBI chr 2:134,660,741...134,847,575
Ensembl chr 2:134,660,808...134,686,219

ammonium chloride

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

RUNX family transcription factor 2

multiple interactions

Ammonium Chloride inhibits the reaction [SOX5 protein inhibits the reaction [Warfarin results in increased expression of RUNX2 mRNA]]

NCBI chr 7:40,106,581...40,353,304
Ensembl chr 7:40,106,532...40,460,687

G

SRY-box transcription factor 5

multiple interactions

Ammonium Chloride inhibits the reaction [SOX5 protein inhibits the reaction [Warfarin results in increased expression of RUNX2 mRNA]]

NCBI chr 5:49,159,950...50,166,463
Ensembl chr 5:49,504,551...50,161,558

bethanechol

term browser

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Object Name

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Evidence

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Source

PubMed Reference(s)

RGD Reference(s)

Position

G

C-X-C motif chemokine ligand 10

increases expression

Bethanechol results in increased expression of CXCL10 mRNA

NCBI chr 8:71,693,641...71,695,948
Ensembl chr 8:71,693,339...71,695,948

G

C-X-C motif chemokine ligand 8

increases expression

Bethanechol results in increased expression of CXCL8 mRNA

NCBI chr 8:69,932,646...69,935,861
Ensembl chr 8:69,932,643...69,935,861

G

interferon gamma

increases expression

Bethanechol results in increased expression of IFNG mRNA

NCBI chr 5:32,477,906...32,482,670
Ensembl chr 5:32,477,906...32,482,670

G

interleukin 17A

increases expression

Bethanechol results in increased expression of IL17A mRNA

NCBI chr 7:46,013,584...46,017,161
Ensembl chr 7:46,013,584...46,017,153

G

interleukin 1 alpha

increases expression

Bethanechol results in increased expression of IL1A mRNA

NCBI chr 3:43,718,320...43,731,668
Ensembl chr 3:43,718,368...43,731,119

brimonidine tartrate

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

cAMP responsive element binding protein 1

increases phosphorylation
multiple interactions

Brimonidine Tartrate results in increased phosphorylation of CREB1 protein
N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Brimonidine Tartrate results in increased phosphorylation of CREB1 protein]

NCBI chr15:110,705,548...110,773,037
Ensembl chr15:110,705,496...110,771,728

Butyrylcholine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

butyrylcholinesterase

increases hydrolysis

BCHE protein results in increased hydrolysis of butyrylcholine

NCBI chr13:104,946,732...105,007,568

butyrylthiocholine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

butyrylcholinesterase

increases hydrolysis

BCHE protein results in increased hydrolysis of Butyrylthiocholine

NCBI chr13:104,946,732...105,007,568

cadmium nitrate

term browser

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Object Name

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Evidence

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Source

PubMed Reference(s)

RGD Reference(s)

Position

G

CD14 molecule

affects expression

cadmium nitrate affects the expression of CD14 mRNA

NCBI chr 2:142,348,036...142,349,686
Ensembl chr 2:142,346,360...142,349,581

G

C-X-C motif chemokine ligand 8

affects expression
affects secretion

cadmium nitrate affects the expression of CXCL8 mRNA
cadmium nitrate affects the secretion of CXCL8 protein

NCBI chr 8:69,932,646...69,935,861
Ensembl chr 8:69,932,643...69,935,861

G

defensin beta 1

increases expression

cadmium nitrate results in increased expression of DEFB1 mRNA

G

interferon beta 1

increases expression

cadmium nitrate results in increased expression of IFNB1 mRNA

NCBI chr 1:201,850,935...201,851,495
Ensembl chr 1:201,850,935...201,851,495

G

interleukin 18

increases expression

cadmium nitrate results in increased expression of IL18 mRNA

NCBI chr 9:39,839,959...39,861,258
Ensembl chr 9:39,834,973...39,861,219

G

interleukin 6

increases expression

cadmium nitrate results in increased expression of IL6 mRNA

NCBI chr 9:91,506,421...91,510,830
Ensembl chr 9:91,506,421...91,511,263

G

interleukin-1 beta-like

increases expression

cadmium nitrate results in increased expression of IL1B mRNA

G

mitogen-activated protein kinase 14

affects expression

cadmium nitrate affects the expression of MAPK14 mRNA

NCBI chr 7:31,791,398...31,861,544
Ensembl chr 7:31,790,877...31,862,031

G

mitogen-activated protein kinase 8

increases expression

cadmium nitrate results in increased expression of MAPK8 mRNA

NCBI chr14:88,988,914...89,108,875
Ensembl chr14:88,988,949...89,108,874

G

MYD88 innate immune signal transduction adaptor

affects expression

cadmium nitrate affects the expression of MYD88 mRNA

NCBI chr13:22,976,951...22,979,568
Ensembl chr13:22,966,137...22,983,109

G

nuclear factor kappa B subunit 1

affects expression

cadmium nitrate affects the expression of NFKB1 mRNA

NCBI chr 8:118,391,010...118,478,927
Ensembl chr 8:118,390,638...118,506,691

G

RELA proto-oncogene, NF-kB subunit

increases expression

cadmium nitrate results in increased expression of RELA mRNA

NCBI chr 2:6,594,869...6,602,684
Ensembl chr 2:6,593,969...6,603,469

G

suppressor of cytokine signaling 1

decreases expression

cadmium nitrate results in decreased expression of SOCS1 mRNA

NCBI chr 3:31,879,143...31,883,041
Ensembl chr 3:31,881,225...31,884,967

G

signal transducer and activator of transcription 3

decreases expression

cadmium nitrate results in decreased expression of STAT3 mRNA

NCBI chr12:20,407,316...20,471,091
Ensembl chr12:20,407,233...20,472,992

G

toll like receptor 4

affects expression

cadmium nitrate affects the expression of TLR4 mRNA

NCBI chr 1:258,044,610...258,054,641
Ensembl chr 1:258,044,610...258,058,970

G

toll like receptor 5

increases expression

cadmium nitrate results in increased expression of TLR5 mRNA

NCBI chr10:19,387,666...19,410,024
Ensembl chr10:19,387,666...19,410,024

G

tumor necrosis factor

increases expression

cadmium nitrate results in increased expression of TNF mRNA

NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,628...23,702,416

calcium dichloride

term browser

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Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

glutamyl aminopeptidase

multiple interactions

Calcium Chloride promotes the reaction [ENPEP protein results in increased hydrolysis of Aspartame]

NCBI chr 8:111,765,839...111,858,349
Ensembl chr 8:111,748,514...111,858,510

G

glyceraldehyde-3-phosphate dehydrogenase

multiple interactions

[Sodium Bicarbonate co-treated with Calcium Chloride] results in increased activity of GAPDH protein

NCBI chr 5:64,129,678...64,135,194
Ensembl chr 5:64,129,679...64,133,991

CAR(3:0(Me2))

term browser

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Object Name

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Evidence

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Source

PubMed Reference(s)

RGD Reference(s)

Position

G

solute carrier family 22 member 5

decreases activity

pivaloylcarnitine results in decreased activity of SLC22A5 protein

NCBI chr 2:134,660,741...134,847,575
Ensembl chr 2:134,660,808...134,686,219

choline

term browser

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Object Name

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Evidence

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Source

PubMed Reference(s)

RGD Reference(s)

Position

G

catalase

multiple interactions

[Betaine co-treated with Folic Acid co-treated with Choline co-treated with Vitamin B 12] promotes the reaction [bisphenol A results in decreased expression of CAT protein]; [Betaine co-treated with Folic Acid co-treated with Choline co-treated with Vitamin B 12] results in increased expression of CAT mRNA; [Betaine co-treated with Folic Acid co-treated with Choline co-treated with Vitamin B 12] results in increased expression of CAT protein

NCBI chr 2:26,493,664...26,533,881
Ensembl chr 2:26,487,653...26,581,452

G

DNA methyltransferase 1

multiple interactions

[Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in increased expression of DNMT1 mRNA

NCBI chr 2:68,981,564...69,040,364
Ensembl chr 2:68,981,566...69,029,844

G

DNA methyltransferase 3 alpha

multiple interactions

[Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] inhibits the reaction [bisphenol A results in decreased expression of DNMT3A mRNA]; [Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in increased expression of DNMT3A mRNA

NCBI chr 3:113,501,972...113,609,148
Ensembl chr 3:113,528,926...113,603,087

G

glutathione peroxidase 1

multiple interactions

[Betaine co-treated with Folic Acid co-treated with Choline co-treated with Vitamin B 12] results in increased expression of GPX1 mRNA; [bisphenol A co-treated with [Betaine co-treated with Folic Acid co-treated with Choline co-treated with Vitamin B 12]] results in increased expression of GPX1 mRNA

NCBI chr13:31,916,269...31,917,337
Ensembl chr13:31,916,246...31,917,433

G

glycogen synthase 1

multiple interactions

[Betaine co-treated with Choline co-treated with Folic Acid co-treated with bisphenol A] results in increased methylation of GYS1 promoter; [Betaine co-treated with Choline co-treated with Folic Acid] results in decreased expression of GYS1 mRNA; [Betaine co-treated with Choline co-treated with Folic Acid] results in increased methylation of GYS1 promoter

NCBI chr 6:54,234,600...54,250,211
Ensembl chr 6:54,233,050...54,250,261

G

lactate dehydrogenase A

multiple interactions

[bisphenol A co-treated with Choline co-treated with Folic Acid co-treated with Betaine] results in decreased methylation of LDHA promoter

NCBI chr 2:40,814,163...40,827,284
Ensembl chr 2:40,814,169...40,826,715

G

methylenetetrahydrofolate reductase

multiple interactions

[Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in increased expression of MTHFR mRNA

NCBI chr 6:71,863,637...71,882,118
Ensembl chr 6:71,863,637...71,881,820

G

sucrase-isomaltase

multiple interactions

[Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in increased expression of SI mRNA

NCBI chr13:104,296,281...104,379,558
Ensembl chr13:104,296,283...104,379,478

G

solute carrier family 15 member 1

multiple interactions

[Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] inhibits the reaction [bisphenol A results in decreased expression of SLC15A1 mRNA]; [Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] inhibits the reaction [bisphenol A results in decreased methylation of SLC15A1 promoter]; [Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in increased expression of SLC15A1 mRNA

NCBI chr11:67,652,808...67,690,457
Ensembl chr11:67,652,193...67,710,933

G

solute carrier family 5 member 1

multiple interactions

[Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid co-treated with bisphenol A] results in increased expression of SLC5A1 mRNA; [Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in increased expression of SLC5A1 mRNA

NCBI chr14:48,566,400...48,704,145
Ensembl chr14:48,628,224...48,705,841

G

superoxide dismutase 1

multiple interactions

[Betaine co-treated with Folic Acid co-treated with Choline co-treated with Vitamin B 12] results in increased expression of SOD1 mRNA

NCBI chr13:195,326,573...195,335,273
Ensembl chr13:195,326,649...195,337,729

cobalt dichloride

term browser

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Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

amine oxidase copper containing 1

affects binding

cobaltous chloride binds to AOC1 protein

NCBI chr18:6,309,583...6,321,016
Ensembl chr18:6,309,594...6,320,974

G

heat shock protein 90 beta family member 1

increases expression

cobaltous chloride results in increased expression of HSP90B1 mRNA

NCBI chr 5:80,511,513...80,531,016
Ensembl chr 5:80,511,506...80,530,991

G

heat shock protein family A (Hsp70) member 5

increases expression

cobaltous chloride results in increased expression of HSPA5 mRNA

NCBI chr 1:265,930,044...265,934,959
Ensembl chr 1:265,930,045...265,934,894

colforsin daropate hydrochloride

term browser

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Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

adenylate cyclase activating polypeptide 1

decreases activity

Colforsin results in decreased activity of ADCYAP1 protein alternative form

NCBI chr 6:105,414,628...105,422,294
Ensembl chr 6:105,414,631...105,422,294

G

ATPase copper transporting beta

multiple interactions

Colforsin inhibits the reaction [Copper binds to ATP7B protein]

NCBI chr11:15,892,549...15,942,070
Ensembl chr11:15,876,612...15,942,064

G

CF transmembrane conductance regulator

increases activity

Colforsin results in increased activity of CFTR protein

NCBI chr18:28,627,717...28,818,209
Ensembl chr18:28,627,728...28,817,950

G

cAMP responsive element binding protein 1

multiple interactions
increases phosphorylation

N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Colforsin results in increased phosphorylation of CREB1 protein]

NCBI chr15:110,705,548...110,773,037
Ensembl chr15:110,705,496...110,771,728

copper(II) chloride

term browser

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Object Name

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Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

amine oxidase copper containing 1

increases activity

cupric chloride results in increased activity of AOC1 protein

NCBI chr18:6,309,583...6,321,016
Ensembl chr18:6,309,594...6,320,974

copper(II) sulfate

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

antioxidant 1 copper chaperone

increases expression

Copper Sulfate results in increased expression of ATOX1 mRNA

NCBI chr16:71,299,321...71,314,598
Ensembl chr16:71,299,321...71,314,597

G

cyclin B1

increases secretion

Copper Sulfate results in increased secretion of CCNB1 protein

NCBI chr16:47,338,239...47,348,385
Ensembl chr16:47,338,110...47,348,377

G

cytochrome c oxidase copper chaperone COX17

decreases expression

Copper Sulfate results in decreased expression of COX17 mRNA

NCBI chr13:140,584,286...140,594,636
Ensembl chr13:140,584,363...140,587,621

G

growth hormone releasing hormone

increases expression

Copper Sulfate results in increased expression of GHRH mRNA

NCBI chr17:40,386,725...40,398,312
Ensembl chr17:40,387,344...40,397,857

G

heat shock protein 90 beta family member 1

increases expression

Copper Sulfate results in increased expression of HSP90B1 mRNA

NCBI chr 5:80,511,513...80,531,016
Ensembl chr 5:80,511,506...80,530,991

G

heat shock protein family A (Hsp70) member 5

increases expression

Copper Sulfate results in increased expression of HSPA5 mRNA

NCBI chr 1:265,930,044...265,934,959
Ensembl chr 1:265,930,045...265,934,894

G

insulin like growth factor 1

increases secretion

Copper Sulfate results in increased secretion of IGF1 protein

NCBI chr 5:81,762,027...81,909,253
Ensembl chr 5:81,775,970...81,848,033

G

somatostatin

decreases expression

Copper Sulfate results in decreased expression of SST mRNA; Copper Sulfate results in decreased expression of SST protein

NCBI chr13:125,337,560...125,338,742
Ensembl chr13:125,337,418...125,338,850

dibenziodolium

term browser

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Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

NFE2 like bZIP transcription factor 2

multiple interactions

diphenyleneiodonium inhibits the reaction [Aldosterone results in increased activity of NFE2L2 protein]

NCBI chr15:82,967,485...83,146,185
Ensembl chr15:82,973,656...83,146,183

diquat

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

catalase

affects activity
multiple interactions
decreases expression

Diquat affects the activity of CAT protein
[Zinc binds to alpha-hydroxy-gamma-methylmercaptobutyric acid] inhibits the reaction [Diquat results in decreased expression of CAT mRNA]

PMID:22558963 PMID:32280687

NCBI chr 2:26,493,664...26,533,881
Ensembl chr 2:26,487,653...26,581,452

G

claudin 1

decreases expression

Diquat results in decreased expression of CLDN1 protein

NCBI chr13:127,714,857...127,730,628
Ensembl chr13:127,712,777...127,730,657

G

claudin 3

decreases expression
multiple interactions

Diquat results in decreased expression of CLDN3 protein
Amino Acids inhibits the reaction [Diquat results in decreased expression of CLDN3 protein]

NCBI chr 3:11,019,073...11,020,102
Ensembl chr 3:11,019,073...11,020,102

G

claudin 4

decreases expression
multiple interactions

Diquat results in decreased expression of CLDN4 protein
Amino Acids inhibits the reaction [Diquat results in decreased expression of CLDN4 protein]

NCBI chr 3:11,039,711...11,053,930
Ensembl chr 3:11,039,706...11,053,925

G

glutathione peroxidase 1

multiple interactions
decreases expression

[Zinc binds to alpha-hydroxy-gamma-methylmercaptobutyric acid] inhibits the reaction [Diquat results in decreased expression of GPX1 mRNA]; Zinc Sulfate inhibits the reaction [Diquat results in decreased expression of GPX1 mRNA]

NCBI chr13:31,916,269...31,917,337
Ensembl chr13:31,916,246...31,917,433

G

interleukin-1 beta-like

increases expression
multiple interactions

Diquat results in increased expression of IL1B mRNA
[Zinc binds to alpha-hydroxy-gamma-methylmercaptobutyric acid] inhibits the reaction [Diquat results in increased expression of IL1B mRNA]; Zinc Sulfate inhibits the reaction [Diquat results in increased expression of IL1B mRNA]

G

NFE2 like bZIP transcription factor 2

decreases expression
multiple interactions

Diquat results in decreased expression of NFE2L2 mRNA
[Zinc binds to alpha-hydroxy-gamma-methylmercaptobutyric acid] inhibits the reaction [Diquat results in decreased expression of NFE2L2 mRNA]; Zinc Sulfate inhibits the reaction [Diquat results in decreased expression of NFE2L2 mRNA]

NCBI chr15:82,967,485...83,146,185
Ensembl chr15:82,973,656...83,146,183

G

occludin

increases expression

Diquat results in increased expression of OCLN protein

NCBI chr16:47,600,175...47,652,435
Ensembl chr16:47,600,212...47,654,033

G

superoxide dismutase 1

multiple interactions
decreases expression

[Zinc binds to alpha-hydroxy-gamma-methylmercaptobutyric acid] inhibits the reaction [Diquat results in decreased expression of SOD1 mRNA]; Zinc Sulfate inhibits the reaction [Diquat results in decreased expression of SOD1 mRNA]

NCBI chr13:195,326,573...195,335,273
Ensembl chr13:195,326,649...195,337,729

G

tryptophan 2,3-dioxygenase

increases expression

Diquat results in increased expression of TDO2 mRNA

NCBI chr 8:44,708,722...44,725,954
Ensembl chr 8:44,708,746...44,740,962

G

tight junction protein 1

decreases expression

Diquat results in decreased expression of TJP1 protein

NCBI chr 1:144,930,387...145,195,857
Ensembl chr 1:144,930,370...145,195,836

G

tight junction protein 2

multiple interactions
decreases expression

Amino Acids inhibits the reaction [Diquat results in decreased expression of TJP2 protein]

NCBI chr 1:222,474,518...222,612,989
Ensembl chr 1:222,474,639...222,612,983

G

tight junction protein 3

decreases expression
multiple interactions

Diquat results in decreased expression of TJP3 protein
Amino Acids inhibits the reaction [Diquat results in decreased expression of TJP3 protein]

NCBI chr 2:74,938,153...74,971,431
Ensembl chr 2:74,938,152...74,971,531

G

tumor necrosis factor

increases expression
multiple interactions

Diquat results in increased expression of TNF mRNA
[Zinc binds to alpha-hydroxy-gamma-methylmercaptobutyric acid] inhibits the reaction [Diquat results in increased expression of TNF mRNA]; Zinc Sulfate inhibits the reaction [Diquat results in increased expression of TNF mRNA]

NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,628...23,702,416

disodium selenite

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

activating transcription factor 4

multiple interactions

Sodium Selenite inhibits the reaction [bisphenol A results in increased expression of ATF4 protein]

NCBI chr 5:8,742,964...8,745,752
Ensembl chr 5:8,742,967...8,745,368

G

activating transcription factor 6

multiple interactions

Sodium Selenite inhibits the reaction [bisphenol A results in increased expression of ATF6 protein]

NCBI chr 4:88,591,279...88,806,156
Ensembl chr 4:88,591,288...88,805,304

G

BCL2 antagonist/killer 1

multiple interactions

Sodium Selenite inhibits the reaction [[Cadmium Chloride co-treated with MIR125A mRNA mutant form] results in increased expression of BAK1 protein]; Sodium Selenite inhibits the reaction [Cadmium Chloride results in increased expression of BAK1 protein]; Sodium Selenite inhibits the reaction [MIR125A mRNA mutant form results in increased expression of BAK1 protein]

NCBI chr 7:29,808,849...29,815,345

G

BCL2 associated X, apoptosis regulator

multiple interactions
affects expression

Sodium Selenite inhibits the reaction [[Cadmium Chloride co-treated with MIR125A mRNA mutant form] results in increased expression of BAX protein]; Sodium Selenite inhibits the reaction [bisphenol A results in increased expression of BAX mRNA]; Sodium Selenite inhibits the reaction [bisphenol A results in increased expression of BAX protein]; Sodium Selenite inhibits the reaction [Cadmium Chloride results in increased expression of BAX protein]; Sodium Selenite inhibits the reaction [MIR125A mRNA mutant form results in increased expression of BAX protein]
Sodium Selenite affects the expression of BAX mRNA

PMID:17342738 PMID:26607349 PMID:37108405

NCBI chr 6:54,222,341...54,228,150
Ensembl chr 6:54,222,336...54,228,140

G

BCL2 apoptosis regulator

multiple interactions

Sodium Selenite inhibits the reaction [bisphenol A results in decreased expression of BCL2 mRNA]; Sodium Selenite inhibits the reaction [bisphenol A results in decreased expression of BCL2 protein]; Sodium Selenite inhibits the reaction [Cadmium Chloride promotes the reaction [MIR125A mRNA mutant form results in decreased expression of BCL2 protein]]; Sodium Selenite inhibits the reaction [Cadmium Chloride results in decreased expression of BCL2 protein]; Sodium Selenite inhibits the reaction [MIR125A mRNA mutant form results in decreased expression of BCL2 protein]

PMID:26607349 PMID:37108405

NCBI chr 1:158,337,403...158,518,214
Ensembl chr 1:158,337,522...158,518,879

G

BCL2 like 1

affects expression
multiple interactions

Sodium Selenite affects the expression of BCL2L1 mRNA
Sodium Selenite affects the reaction [bisphenol A results in decreased expression of BCL2L1 protein]

PMID:17342738 PMID:37108405

NCBI chr17:35,366,139...35,415,798
Ensembl chr17:35,366,143...35,414,694

G

caspase 3

multiple interactions
decreases expression

Sodium Selenite inhibits the reaction [[Cadmium Chloride co-treated with MIR125A mRNA mutant form] results in increased expression of CASP3 protein]; Sodium Selenite inhibits the reaction [bisphenol A results in increased expression of CASP3 protein]; Sodium Selenite inhibits the reaction [Cadmium Chloride results in increased expression of CASP3 protein]; Sodium Selenite inhibits the reaction [Hydrogen Peroxide results in increased activity of CASP3 protein]; Sodium Selenite inhibits the reaction [MIR125A mRNA mutant form results in increased expression of CASP3 protein]
Sodium Selenite results in decreased expression of CASP3 protein

PMID:15191356 PMID:17342738 PMID:26607349 PMID:37108405

NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,751...45,764,213

G

caspase 8

multiple interactions

Sodium Selenite inhibits the reaction [bisphenol A results in increased expression of CASP8 mRNA]

NCBI chr15:104,923,659...104,948,470
Ensembl chr15:104,923,953...104,948,468

G

caspase 9

multiple interactions

Sodium Selenite inhibits the reaction [[Cadmium Chloride co-treated with MIR125A mRNA mutant form] results in increased expression of CASP9 protein]; Sodium Selenite inhibits the reaction [bisphenol A results in increased expression of CASP9 mRNA]; Sodium Selenite inhibits the reaction [Cadmium Chloride results in increased expression of CASP9 protein]; Sodium Selenite inhibits the reaction [MIR125A mRNA mutant form results in increased expression of CASP9 protein]

PMID:26607349 PMID:37108405

NCBI chr 6:74,707,597...74,730,033
Ensembl chr 6:74,706,516...74,730,007

G

catalase

multiple interactions

Sodium Selenite inhibits the reaction [bisphenol A results in decreased activity of CAT protein]

NCBI chr 2:26,493,664...26,533,881
Ensembl chr 2:26,487,653...26,581,452

G

claudin 1

multiple interactions

Sodium Selenite inhibits the reaction [bisphenol A results in decreased expression of CLDN1 protein]

NCBI chr13:127,714,857...127,730,628
Ensembl chr13:127,712,777...127,730,657

G

DNA damage inducible transcript 3

multiple interactions

Sodium Selenite inhibits the reaction [bisphenol A results in increased expression of DDIT3 protein]

NCBI chr 5:22,785,441...22,789,867
Ensembl chr 5:22,785,445...22,789,829

G

eukaryotic translation initiation factor 2 alpha kinase 3

multiple interactions

Sodium Selenite inhibits the reaction [bisphenol A results in increased phosphorylation of EIF2AK3 protein]

NCBI chr 3:57,423,894...57,506,247
Ensembl chr 3:57,423,943...57,506,245

G

endoplasmic reticulum to nucleus signaling 1

multiple interactions

Sodium Selenite inhibits the reaction [bisphenol A results in increased expression of ERN1 protein]

NCBI chr12:14,881,913...14,963,290
Ensembl chr12:14,881,923...14,963,284

G

glutathione peroxidase 4

increases activity

Sodium Selenite results in increased activity of GPX4 protein

NCBI chr 2:77,321,568...77,323,931
Ensembl chr 2:77,320,464...77,323,931

G

heat shock protein family A (Hsp70) member 5

multiple interactions

Sodium Selenite inhibits the reaction [bisphenol A results in increased expression of HSPA5 protein]

NCBI chr 1:265,930,044...265,934,959
Ensembl chr 1:265,930,045...265,934,894

G

interferon gamma

multiple interactions

Sodium Selenite inhibits the reaction [bisphenol A results in increased expression of IFNG mRNA]

NCBI chr 5:32,477,906...32,482,670
Ensembl chr 5:32,477,906...32,482,670

G

interleukin 10

multiple interactions

Sodium Selenite inhibits the reaction [bisphenol A results in decreased expression of IL10 mRNA]

NCBI chr 9:67,400,727...67,405,941
Ensembl chr 9:67,400,728...67,405,378

G

interleukin 17A

multiple interactions

Sodium Selenite inhibits the reaction [bisphenol A results in increased expression of IL17A mRNA]

NCBI chr 7:46,013,584...46,017,161
Ensembl chr 7:46,013,584...46,017,153

G

interleukin 6

multiple interactions

Sodium Selenite inhibits the reaction [bisphenol A results in increased expression of IL6 mRNA]

NCBI chr 9:91,506,421...91,510,830
Ensembl chr 9:91,506,421...91,511,263

G

interleukin-1 beta-like

multiple interactions

Sodium Selenite inhibits the reaction [bisphenol A results in increased expression of IL1B mRNA]

G

mitogen-activated protein kinase 1

increases expression

Sodium Selenite results in increased expression of MAPK1 protein

NCBI chr14:50,083,079...50,165,528
Ensembl chr14:50,082,896...50,165,513

G

mitogen-activated protein kinase 3

increases expression

Sodium Selenite results in increased expression of MAPK3 protein

NCBI chr 3:18,291,444...18,299,410
Ensembl chr 3:18,291,445...18,299,567

G

microRNA mir-125a

multiple interactions

Sodium Selenite inhibits the reaction [[Cadmium Chloride co-treated with MIR125A mRNA mutant form] results in increased expression of BAK1 protein]; Sodium Selenite inhibits the reaction [[Cadmium Chloride co-treated with MIR125A mRNA mutant form] results in increased expression of BAX protein]; Sodium Selenite inhibits the reaction [[Cadmium Chloride co-treated with MIR125A mRNA mutant form] results in increased expression of CASP3 protein]; Sodium Selenite inhibits the reaction [[Cadmium Chloride co-treated with MIR125A mRNA mutant form] results in increased expression of CASP9 protein]; Sodium Selenite inhibits the reaction [Cadmium Chloride promotes the reaction [MIR125A mRNA mutant form results in decreased expression of BCL2 protein]]; Sodium Selenite inhibits the reaction [Cadmium results in decreased expression of MIR125A mRNA]; Sodium Selenite inhibits the reaction [MIR125A mRNA mutant form results in decreased expression of BCL2 protein]; Sodium Selenite inhibits the reaction [MIR125A mRNA mutant form results in increased expression of BAK1 protein]; Sodium Selenite inhibits the reaction [MIR125A mRNA mutant form results in increased expression of BAX protein]; Sodium Selenite inhibits the reaction [MIR125A mRNA mutant form results in increased expression of CASP3 protein]; Sodium Selenite inhibits the reaction [MIR125A mRNA mutant form results in increased expression of CASP9 protein]

NCBI chr 6:58,331,566...58,331,645
Ensembl chr 6:58,331,566...58,331,645

G

occludin

multiple interactions

Sodium Selenite affects the reaction [bisphenol A results in decreased expression of OCLN protein]

NCBI chr16:47,600,175...47,652,435
Ensembl chr16:47,600,212...47,654,033

G

proopiomelanocortin

multiple interactions

Ditiocarb promotes the reaction [Sodium Selenite inhibits the reaction [POMC protein results in increased secretion of Hydrocortisone]]; Sodium Selenite inhibits the reaction [POMC protein results in increased secretion of Hydrocortisone]

NCBI chr 3:113,661,712...113,668,558
Ensembl chr 3:113,661,004...113,670,418

G

tight junction protein 1

multiple interactions

Sodium Selenite affects the reaction [bisphenol A results in decreased expression of TJP1 protein]

NCBI chr 1:144,930,387...145,195,857
Ensembl chr 1:144,930,370...145,195,836

G

tumor necrosis factor

multiple interactions

Sodium Selenite inhibits the reaction [bisphenol A results in increased expression of TNF mRNA]

NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,628...23,702,416

flunixin meglumine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP-binding cassette, sub-family B (MDR/TAP), member 1

affects expression

flunixin meglumine affects the expression of ABCB1 mRNA

NCBI chr 9:93,049,955...93,146,469

G

cytochrome P450 family 1 subfamily A member 2

affects expression

flunixin meglumine affects the expression of CYP1A2 mRNA

NCBI chr 7:58,779,529...58,786,155
Ensembl chr 7:58,779,475...58,786,100

G

cytochrome P450 family 2 subfamily E member 1

affects expression

flunixin meglumine affects the expression of CYP2E1 mRNA

NCBI chr14:141,690,737...141,703,078
Ensembl chr14:141,690,426...141,736,817

G

cytochrome P450 family 3 subfamily A member 22

affects expression

flunixin meglumine affects the expression of CYP3A22 mRNA

NCBI chr 3:6,617,256...6,665,179
Ensembl chr 3:6,615,343...6,822,817

G

cytochrome P450 family 3 subfamily A member 29

affects expression

flunixin meglumine affects the expression of CYP3A29 mRNA

NCBI chr 3:6,738,502...6,778,121
Ensembl chr 3:6,738,486...6,778,944

G

sulfotransferase family 1A member 3

affects expression

flunixin meglumine affects the expression of SULT1A1 mRNA

NCBI chr 3:18,351,205...18,354,653
Ensembl chr 3:18,351,194...18,354,649

glycine betaine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

activating transcription factor 4

multiple interactions

Betaine inhibits the reaction [Glyphosate results in increased expression of ATF4 mRNA]; Betaine inhibits the reaction [Glyphosate results in increased expression of ATF4 protein]

NCBI chr 5:8,742,964...8,745,752
Ensembl chr 5:8,742,967...8,745,368

G

activating transcription factor 6

multiple interactions

Betaine inhibits the reaction [Glyphosate results in increased expression of ATF6 mRNA]

NCBI chr 4:88,591,279...88,806,156
Ensembl chr 4:88,591,288...88,805,304

G

BCL2 associated X, apoptosis regulator

multiple interactions

[Betaine co-treated with Glyphosate] results in increased expression of BAX mRNA

NCBI chr 6:54,222,341...54,228,150
Ensembl chr 6:54,222,336...54,228,140

G

caspase 3

multiple interactions

Betaine inhibits the reaction [Glyphosate results in increased expression of CASP3 mRNA]

NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,751...45,764,213

G

caspase 9

multiple interactions

Betaine inhibits the reaction [Glyphosate results in increased expression of CASP9 mRNA]

NCBI chr 6:74,707,597...74,730,033
Ensembl chr 6:74,706,516...74,730,007

G

catalase

multiple interactions

[Betaine co-treated with Folic Acid co-treated with Choline co-treated with Vitamin B 12] promotes the reaction [bisphenol A results in decreased expression of CAT protein]; [Betaine co-treated with Folic Acid co-treated with Choline co-treated with Vitamin B 12] results in increased expression of CAT mRNA; [Betaine co-treated with Folic Acid co-treated with Choline co-treated with Vitamin B 12] results in increased expression of CAT protein; Betaine inhibits the reaction [Glyphosate results in increased expression of CAT mRNA]

PMID:29129240 PMID:36584959

NCBI chr 2:26,493,664...26,533,881
Ensembl chr 2:26,487,653...26,581,452

G

claudin 1

multiple interactions

Betaine inhibits the reaction [Glyphosate results in decreased expression of CLDN1 mRNA]; Betaine inhibits the reaction [Glyphosate results in decreased expression of CLDN1 protein]

NCBI chr13:127,714,857...127,730,628
Ensembl chr13:127,712,777...127,730,657

G

DNA damage inducible transcript 3

multiple interactions

Betaine inhibits the reaction [Glyphosate results in increased expression of DDIT3 mRNA]

NCBI chr 5:22,785,441...22,789,867
Ensembl chr 5:22,785,445...22,789,829

G

DNA methyltransferase 1

multiple interactions

[Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in increased expression of DNMT1 mRNA

NCBI chr 2:68,981,564...69,040,364
Ensembl chr 2:68,981,566...69,029,844

G

DNA methyltransferase 3 alpha

multiple interactions

[Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] inhibits the reaction [bisphenol A results in decreased expression of DNMT3A mRNA]; [Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in increased expression of DNMT3A mRNA

NCBI chr 3:113,501,972...113,609,148
Ensembl chr 3:113,528,926...113,603,087

G

eukaryotic translation initiation factor 2 alpha kinase 3

multiple interactions

Betaine inhibits the reaction [Glyphosate results in increased expression of EIF2AK3 mRNA]; Betaine inhibits the reaction [Glyphosate results in increased expression of EIF2AK3 protein]

NCBI chr 3:57,423,894...57,506,247
Ensembl chr 3:57,423,943...57,506,245

G

eukaryotic translation initiation factor 2 subunit alpha

multiple interactions

Betaine inhibits the reaction [Glyphosate results in increased expression of EIF2S1 mRNA]; Betaine inhibits the reaction [Glyphosate results in increased expression of EIF2S1 protein]

NCBI chr 7:91,085,025...91,109,835
Ensembl chr 7:91,085,335...91,109,827

G

endoplasmic reticulum to nucleus signaling 1

multiple interactions

Betaine inhibits the reaction [Glyphosate results in increased expression of ERN1 mRNA]

NCBI chr12:14,881,913...14,963,290
Ensembl chr12:14,881,923...14,963,284

G

glutathione peroxidase 1

multiple interactions

[Betaine co-treated with Folic Acid co-treated with Choline co-treated with Vitamin B 12] results in increased expression of GPX1 mRNA; [bisphenol A co-treated with [Betaine co-treated with Folic Acid co-treated with Choline co-treated with Vitamin B 12]] results in increased expression of GPX1 mRNA

NCBI chr13:31,916,269...31,917,337
Ensembl chr13:31,916,246...31,917,433

G

glutathione peroxidase 2

multiple interactions

[Betaine co-treated with Glyphosate] results in increased expression of GPX2 mRNA

NCBI chr 7:89,007,636...89,011,620
Ensembl chr 7:89,007,375...89,011,620

G

glycogen synthase 1

multiple interactions

[Betaine co-treated with Choline co-treated with Folic Acid co-treated with bisphenol A] results in increased methylation of GYS1 promoter; [Betaine co-treated with Choline co-treated with Folic Acid] results in decreased expression of GYS1 mRNA; [Betaine co-treated with Choline co-treated with Folic Acid] results in increased methylation of GYS1 promoter

NCBI chr 6:54,234,600...54,250,211
Ensembl chr 6:54,233,050...54,250,261

G

heat shock protein 90 beta family member 1

multiple interactions

Betaine inhibits the reaction [Glyphosate results in increased expression of HSP90B1 mRNA]; Betaine inhibits the reaction [Glyphosate results in increased expression of HSP90B1 protein]

NCBI chr 5:80,511,513...80,531,016
Ensembl chr 5:80,511,506...80,530,991

G

lactate dehydrogenase A

multiple interactions

[bisphenol A co-treated with Choline co-treated with Folic Acid co-treated with Betaine] results in decreased methylation of LDHA promoter

NCBI chr 2:40,814,163...40,827,284
Ensembl chr 2:40,814,169...40,826,715

G

mitofusin 1

multiple interactions

Betaine inhibits the reaction [Glyphosate results in increased expression of MFN1 mRNA]

NCBI chr13:117,404,637...117,441,750
Ensembl chr13:117,404,699...117,442,481

G

methylenetetrahydrofolate reductase

multiple interactions

[Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in increased expression of MTHFR mRNA

NCBI chr 6:71,863,637...71,882,118
Ensembl chr 6:71,863,637...71,881,820

G

NFE2 like bZIP transcription factor 2

multiple interactions

Betaine inhibits the reaction [Glyphosate results in increased expression of NFE2L2 mRNA]

NCBI chr15:82,967,485...83,146,185
Ensembl chr15:82,973,656...83,146,183

G

NAD(P)H quinone dehydrogenase 1

multiple interactions

Betaine inhibits the reaction [Glyphosate results in increased expression of NQO1 mRNA]

NCBI chr 6:17,292,962...17,302,593
Ensembl chr 6:17,292,770...17,302,590

G

proliferating cell nuclear antigen

multiple interactions

Betaine inhibits the reaction [Glyphosate results in increased expression of PCNA mRNA]; Betaine inhibits the reaction [Glyphosate results in increased expression of PCNA protein]

NCBI chr17:14,137,746...14,142,584
Ensembl chr17:14,136,886...14,142,744

G

succinate dehydrogenase complex flavoprotein subunit A

multiple interactions

Betaine inhibits the reaction [Glyphosate results in increased expression of SDHA mRNA]

NCBI chr16:79,838,442...79,862,956
Ensembl chr16:79,834,044...79,862,524

G

sucrase-isomaltase

multiple interactions

[Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in increased expression of SI mRNA

NCBI chr13:104,296,281...104,379,558
Ensembl chr13:104,296,283...104,379,478

G

solute carrier family 15 member 1

multiple interactions

[Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] inhibits the reaction [bisphenol A results in decreased expression of SLC15A1 mRNA]; [Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] inhibits the reaction [bisphenol A results in decreased methylation of SLC15A1 promoter]; [Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in increased expression of SLC15A1 mRNA

NCBI chr11:67,652,808...67,690,457
Ensembl chr11:67,652,193...67,710,933

G

solute carrier family 5 member 1

multiple interactions

[Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid co-treated with bisphenol A] results in increased expression of SLC5A1 mRNA; [Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in increased expression of SLC5A1 mRNA

NCBI chr14:48,566,400...48,704,145
Ensembl chr14:48,628,224...48,705,841

G

superoxide dismutase 1

multiple interactions

[Betaine co-treated with Folic Acid co-treated with Choline co-treated with Vitamin B 12] results in increased expression of SOD1 mRNA

NCBI chr13:195,326,573...195,335,273
Ensembl chr13:195,326,649...195,337,729

G

superoxide dismutase 2

multiple interactions

Betaine inhibits the reaction [Glyphosate results in increased expression of SOD2 mRNA]

NCBI chr 1:7,679,352...7,689,564
Ensembl chr 1:7,679,352...7,689,560

G

ubiquinol-cytochrome c reductase binding protein

multiple interactions

[Betaine co-treated with Glyphosate] results in decreased expression of UQCRB mRNA

NCBI chr 4:40,403,272...40,409,080
Ensembl chr 4:40,403,109...40,409,057

G

X-box binding protein 1

multiple interactions

Betaine inhibits the reaction [Glyphosate results in increased expression of XBP1 mRNA]

NCBI chr14:46,011,239...46,016,526
Ensembl chr14:46,008,377...46,016,526

lead diacetate

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

AKT serine/threonine kinase 1

increases expression

lead acetate results in increased expression of AKT1 mRNA

G

anti-Mullerian hormone

decreases expression
multiple interactions

lead acetate results in decreased expression of AMH mRNA
lead acetate results in decreased expression of and results in decreased secretion of AMH protein

NCBI chr 2:76,415,564...76,418,315
Ensembl chr 2:76,414,427...76,418,312

G

follicle stimulating hormone subunit beta

multiple interactions

lead acetate inhibits the reaction [FSHB protein results in increased chemical synthesis of Estradiol]

NCBI chr 2:30,395,769...30,399,282
Ensembl chr 2:30,395,018...30,399,274

G

follicle stimulating hormone receptor

decreases expression

lead acetate results in decreased expression of FSHR mRNA

NCBI chr 3:91,607,236...91,775,255
Ensembl chr 3:91,607,305...91,774,683

G

heat shock protein 90 beta family member 1

increases expression

lead acetate results in increased expression of HSP90B1 mRNA

NCBI chr 5:80,511,513...80,531,016
Ensembl chr 5:80,511,506...80,530,991

G

heat shock protein family A (Hsp70) member 5

increases expression

lead acetate results in increased expression of HSPA5 mRNA

NCBI chr 1:265,930,044...265,934,959
Ensembl chr 1:265,930,045...265,934,894

G

inhibin subunit alpha

multiple interactions

lead acetate results in decreased expression of and results in decreased secretion of [INHBB protein binds to INHA protein]

NCBI chr15:121,581,847...121,586,020
Ensembl chr15:121,580,803...121,586,006

G

inhibin subunit beta B

decreases expression
multiple interactions

lead acetate results in decreased expression of INHBB mRNA
lead acetate results in decreased expression of and results in decreased secretion of [INHBB protein binds to INHA protein]; lead acetate results in decreased expression of and results in decreased secretion of INHBB protein

NCBI chr15:30,999,994...31,004,405
Ensembl chr15:30,999,520...31,004,405

G

mechanistic target of rapamycin kinase

increases expression

lead acetate results in increased expression of MTOR mRNA

NCBI chr 6:71,286,989...71,412,913
Ensembl chr 6:71,286,989...71,412,888

methoctramine tetrahydrochloride

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

cholinergic receptor muscarinic 2

multiple interactions

methoctramine inhibits the reaction [Quinuclidinyl Benzilate binds to CHRM2 protein]

NCBI chr18:12,455,139...12,600,314
Ensembl chr18:12,455,145...12,600,186

monosodium L-glutamate

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

acetyl-CoA carboxylase alpha

increases expression
multiple interactions

Sodium Glutamate results in increased expression of ACACA mRNA
Dietary Fats inhibits the reaction [Sodium Glutamate results in increased expression of ACACA mRNA]

NCBI chr12:38,580,916...38,875,067
Ensembl chr12:38,581,457...38,824,712

G

acyl-CoA oxidase 1

increases expression

Sodium Glutamate results in increased expression of ACOX1 mRNA

NCBI chr12:5,450,913...5,479,550
Ensembl chr12:5,439,361...5,479,546

G

fatty acid synthase

multiple interactions
increases expression

Dietary Fats inhibits the reaction [Sodium Glutamate results in increased expression of FASN mRNA]

NCBI chr12:922,405...937,560
Ensembl chr12:920,509...937,561

G

free fatty acid receptor 2

multiple interactions
affects expression

Dietary Fats affects the reaction [Sodium Glutamate affects the expression of FFAR2 mRNA]; Sodium Glutamate affects the reaction [Dietary Fats affects the expression of FFAR2 mRNA]

NCBI chr 6:44,899,879...44,904,461
Ensembl chr 6:44,901,159...44,904,459

G

free fatty acid receptor 4

affects expression
multiple interactions

Sodium Glutamate affects the expression of FFAR4 mRNA
Dietary Fats affects the reaction [Sodium Glutamate affects the expression of FFAR4 mRNA]; Sodium Glutamate affects the reaction [Dietary Fats affects the expression of FFAR4 mRNA]

Ensembl chr14:105,011,942...105,037,498

G

G protein-coupled receptor 119

affects expression
multiple interactions

Sodium Glutamate affects the expression of GPR119 mRNA
Dietary Fats affects the reaction [Sodium Glutamate affects the expression of GPR119 mRNA]; Sodium Glutamate affects the reaction [Dietary Fats affects the expression of GPR119 mRNA]

NCBI chr X:106,872,225...106,873,299
Ensembl chr X:106,872,225...106,873,299

G

liver carboxylesterase-like

multiple interactions

Sodium Glutamate inhibits the reaction [Dietary Fats results in decreased expression of CES1 mRNA]

G

patatin like phospholipase domain containing 2

increases expression

Sodium Glutamate results in increased expression of PNPLA2 mRNA

NCBI chr 2:513,065...517,962
Ensembl chr 2:513,077...518,182

G

sterol regulatory element binding transcription factor 1

multiple interactions
increases expression

Dietary Fats inhibits the reaction [Sodium Glutamate results in increased expression of SREBF1 mRNA]

NCBI chr12:60,733,967...60,750,951
Ensembl chr12:60,733,907...60,751,267

O-acetyl-L-carnitine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

solute carrier family 22 member 5

increases uptake

SLC22A5 protein results in increased uptake of Acetylcarnitine

NCBI chr 2:134,660,741...134,847,575
Ensembl chr 2:134,660,808...134,686,219

paraquat

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

aconitase 1

decreases activity

Paraquat results in decreased activity of ACO1 protein

NCBI chr10:33,937,833...34,001,895
Ensembl chr10:33,937,833...34,001,900

G

amine oxidase copper containing 1

increases expression
multiple interactions

Paraquat results in increased expression of AOC1 protein
Glutathione inhibits the reaction [Paraquat results in increased expression of AOC1 protein]

NCBI chr18:6,309,583...6,321,016
Ensembl chr18:6,309,594...6,320,974

G

BCL2 apoptosis regulator

multiple interactions
decreases expression

MYD88 protein affects the reaction [Paraquat results in decreased expression of BCL2 protein]

NCBI chr 1:158,337,403...158,518,214
Ensembl chr 1:158,337,522...158,518,879

G

BCL2 like 1

multiple interactions
decreases expression

MYD88 protein affects the reaction [Paraquat results in decreased expression of BCL2L1 mRNA]

NCBI chr17:35,366,139...35,415,798
Ensembl chr17:35,366,143...35,414,694

G

beclin 1

multiple interactions

3-methyladenine affects the reaction [[MYD88 protein affects the susceptibility to Paraquat] which affects the expression of BECN1 mRNA]; 3-methyladenine affects the reaction [Paraquat affects the reaction [MYD88 protein affects the expression of BECN1 protein]]; [MYD88 protein affects the susceptibility to Paraquat] which affects the expression of BECN1 mRNA; Paraquat affects the reaction [MYD88 protein affects the expression of BECN1 protein]; Sirolimus affects the reaction [[MYD88 protein affects the susceptibility to Paraquat] which affects the expression of BECN1 mRNA]; Sirolimus affects the reaction [Paraquat affects the reaction [MYD88 protein affects the expression of BECN1 protein]]

NCBI chr12:20,041,914...20,054,249
Ensembl chr12:20,041,956...20,054,373

G

caspase 3

increases expression
multiple interactions

Paraquat results in increased expression of CASP3 mRNA
MYD88 protein affects the reaction [Paraquat results in increased activity of and results in increased cleavage of CASP3 protein]; MYD88 protein affects the reaction [Paraquat results in increased expression of CASP3 mRNA]; Paraquat results in increased activity of and results in increased cleavage of CASP3 protein

NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,751...45,764,213

G

catalase

decreases response to substance
multiple interactions

CAT protein results in decreased susceptibility to Paraquat
3-methyladenine affects the reaction [[MYD88 protein affects the susceptibility to Paraquat] which affects the activity of CAT protein]; [MYD88 protein affects the susceptibility to Paraquat] which affects the activity of CAT protein; CAT protein inhibits the reaction [Paraquat results in increased abundance of Hydrogen Peroxide]

PMID:10752666 PMID:11039594 PMID:34811946

NCBI chr 2:26,493,664...26,533,881
Ensembl chr 2:26,487,653...26,581,452

G

cyclin dependent kinase 2

multiple interactions
increases expression

MYD88 protein affects the reaction [Paraquat results in increased expression of CDK2 protein]

NCBI chr 5:21,365,723...21,372,170
Ensembl chr 5:21,365,764...21,372,168

G

claudin 1

decreases expression

Paraquat results in decreased expression of CLDN1 protein

NCBI chr13:127,714,857...127,730,628
Ensembl chr13:127,712,777...127,730,657

G

cytochrome P450 family 2 subfamily B member 6B

multiple interactions
increases expression

[Glutathione co-treated with Paraquat] results in decreased expression of CYP2B6B mRNA
Paraquat results in increased expression of CYP2B6B mRNA

NCBI chr 6:49,158,175...49,173,872
Ensembl chr 6:49,110,812...49,178,334

G

cytochrome P450 3A39

increases expression
multiple interactions

Paraquat results in increased expression of CYP3A39 mRNA
Glutathione inhibits the reaction [Paraquat results in increased expression of CYP3A39 mRNA]

G

dynactin subunit 4

multiple interactions

3-methyladenine affects the reaction [[MYD88 protein affects the susceptibility to Paraquat] which affects the expression of DCTN4 mRNA]; [MYD88 protein affects the susceptibility to Paraquat] which affects the expression of DCTN4 mRNA; Sirolimus affects the reaction [[MYD88 protein affects the susceptibility to Paraquat] which affects the expression of DCTN4 mRNA]

NCBI chr 2:151,681,001...151,713,923
Ensembl chr 2:151,681,003...151,783,746

G

DnaJ heat shock protein family (Hsp40) member C7

multiple interactions

[Glutathione co-treated with Paraquat] results in increased expression of DNAJC7 mRNA

NCBI chr12:20,725,937...20,756,295
Ensembl chr12:20,725,975...20,759,000

G

fatty acid binding protein 2

increases activity
multiple interactions

Paraquat results in increased activity of FABP2 protein
Glutathione inhibits the reaction [Paraquat results in increased activity of FABP2 protein]

NCBI chr 8:104,464,342...104,468,059
Ensembl chr 8:104,464,342...104,470,480

G

FYVE, RhoGEF and PH domain containing 4

multiple interactions
increases expression

3-methyladenine affects the reaction [MYD88 protein affects the reaction [Paraquat results in increased expression of DNM1L mRNA]]; 3-methyladenine affects the reaction [MYD88 protein affects the reaction [Paraquat results in increased expression of DNM1L protein]]; MYD88 protein affects the reaction [Paraquat results in increased expression of DNM1L mRNA]; MYD88 protein affects the reaction [Paraquat results in increased expression of DNM1L protein]; Sirolimus affects the reaction [MYD88 protein affects the reaction [Paraquat results in increased expression of DNM1L mRNA]]
Paraquat results in increased expression of DNM1L mRNA; Paraquat results in increased expression of DNM1L protein

NCBI chr 5:41,571,054...41,636,058
Ensembl chr 5:41,570,282...41,636,028

G

fission, mitochondrial 1

increases expression
affects expression
multiple interactions

Paraquat results in increased expression of FIS1 mRNA
Paraquat affects the expression of FIS1 protein
3-methyladenine affects the reaction [MYD88 protein affects the reaction [Paraquat results in increased expression of FIS1 mRNA]]; MYD88 protein affects the reaction [Paraquat affects the expression of FIS1 protein]; MYD88 protein affects the reaction [Paraquat results in increased expression of FIS1 mRNA]; Sirolimus affects the reaction [MYD88 protein affects the reaction [Paraquat affects the expression of FIS1 protein]]; Sirolimus affects the reaction [MYD88 protein affects the reaction [Paraquat results in increased expression of FIS1 mRNA]]

NCBI chr 3:8,938,250...8,942,102
Ensembl chr 3:8,937,453...8,946,955

G

glucose-6-phosphate dehydrogenase

affects activity

Paraquat affects the activity of G6PD protein

NCBI chr X:125,029,147...125,041,040
Ensembl chr X:125,029,150...125,041,040

G

glyceraldehyde-3-phosphate dehydrogenase

multiple interactions
decreases activity

Selenium inhibits the reaction [Paraquat results in decreased activity of GAPDH protein]

PMID:11814328 PMID:17055214

NCBI chr 5:64,129,678...64,135,194
Ensembl chr 5:64,129,679...64,133,991

G

glutamate-cysteine ligase modifier subunit

multiple interactions

[Glutathione co-treated with Paraquat] results in increased expression of GCLM mRNA

NCBI chr 4:123,371,198...123,390,130
Ensembl chr 4:123,371,193...123,390,131

G

glutathione peroxidase 1

multiple interactions

3-methyladenine affects the reaction [[MYD88 protein affects the susceptibility to Paraquat] which affects the expression of GPX1 mRNA]; [MYD88 protein affects the susceptibility to Paraquat] which affects the expression of GPX1 mRNA; [MYD88 protein affects the susceptibility to Paraquat] which affects the expression of GPX1 protein; Sirolimus affects the reaction [[MYD88 protein affects the susceptibility to Paraquat] which affects the expression of GPX1 mRNA]

NCBI chr13:31,916,269...31,917,337
Ensembl chr13:31,916,246...31,917,433

G

glutathione peroxidase 4

multiple interactions
increases expression

[Glutathione co-treated with Paraquat] results in increased expression of GPX4 mRNA
Paraquat results in increased expression of GPX4 mRNA

NCBI chr 2:77,321,568...77,323,931
Ensembl chr 2:77,320,464...77,323,931

G

glutathione-disulfide reductase

affects activity

Paraquat affects the activity of GSR protein

NCBI chr15:54,382,564...54,433,989
Ensembl chr15:54,382,567...54,433,984

G

heat shock protein 90 alpha family class A member 1

multiple interactions

[Glutathione co-treated with Paraquat] results in decreased expression of HSP90AA1 mRNA

G

interferon gamma

increases expression
multiple interactions

Paraquat results in increased expression of IFNG mRNA
Glutathione inhibits the reaction [Paraquat results in increased expression of IFNG mRNA]

NCBI chr 5:32,477,906...32,482,670
Ensembl chr 5:32,477,906...32,482,670

G

interleukin 10

multiple interactions

[Glutathione co-treated with Paraquat] results in increased expression of IL10 mRNA

NCBI chr 9:67,400,727...67,405,941
Ensembl chr 9:67,400,728...67,405,378

G

glutathione S-transferase alpha M14

decreases expression
multiple interactions

Paraquat results in decreased expression of GSTA1 mRNA
[Glutathione co-treated with Paraquat] results in increased expression of GSTA2 mRNA; Glutathione inhibits the reaction [Paraquat results in decreased expression of GSTA1 mRNA]

NCBI chr 7:46,553,813...46,567,596

G

interleukin-1 beta-like

increases expression

Paraquat results in increased expression of IL1B mRNA

G

microtubule associated protein 1 light chain 3 beta

multiple interactions

3-methyladenine affects the reaction [Paraquat affects the reaction [MYD88 protein affects the lipidation of MAP1LC3B protein]]; Paraquat affects the reaction [MYD88 protein affects the lipidation of MAP1LC3B protein]; Sirolimus affects the reaction [Paraquat affects the reaction [MYD88 protein affects the lipidation of MAP1LC3B protein]]

NCBI chr 6:1,919,879...1,941,069
Ensembl chr 6:1,915,387...1,941,069

G

marker of proliferation Ki-67

decreases expression
multiple interactions

Paraquat results in decreased expression of MKI67 protein
3-methyladenine affects the reaction [MYD88 protein affects the reaction [Paraquat results in decreased expression of MKI67 protein]]; MYD88 protein affects the reaction [Paraquat results in decreased expression of MKI67 protein]

NCBI chr14:137,266,622...137,296,312

G

mechanistic target of rapamycin kinase

decreases phosphorylation
multiple interactions

Paraquat results in decreased phosphorylation of MTOR protein
MYD88 protein affects the reaction [Paraquat results in decreased phosphorylation of MTOR protein]

NCBI chr 6:71,286,989...71,412,913
Ensembl chr 6:71,286,989...71,412,888

G

MYD88 innate immune signal transduction adaptor

increases expression
multiple interactions
increases response to substance

Paraquat results in increased expression of MYD88 protein
3-methyladenine affects the reaction [[MYD88 protein affects the susceptibility to Paraquat] which affects the activity of CAT protein]; 3-methyladenine affects the reaction [[MYD88 protein affects the susceptibility to Paraquat] which affects the expression of BECN1 mRNA]; 3-methyladenine affects the reaction [[MYD88 protein affects the susceptibility to Paraquat] which affects the expression of DCTN4 mRNA]; 3-methyladenine affects the reaction [[MYD88 protein affects the susceptibility to Paraquat] which affects the expression of GPX1 mRNA]; 3-methyladenine affects the reaction [[MYD88 protein affects the susceptibility to Paraquat] which affects the expression of SOD1 mRNA]; 3-methyladenine affects the reaction [MYD88 protein affects the reaction [Paraquat results in decreased expression of MKI67 protein]]; 3-methyladenine affects the reaction [MYD88 protein affects the reaction [Paraquat results in decreased expression of OPA1 mRNA]]; 3-methyladenine affects the reaction [MYD88 protein affects the reaction [Paraquat results in decreased expression of TOMM20 protein]]; 3-methyladenine affects the reaction [MYD88 protein affects the reaction [Paraquat results in increased expression of DNM1L mRNA]]; 3-methyladenine affects the reaction [MYD88 protein affects the reaction [Paraquat results in increased expression of DNM1L protein]]; 3-methyladenine affects the reaction [MYD88 protein affects the reaction [Paraquat results in increased expression of FIS1 mRNA]]; 3-methyladenine affects the reaction [MYD88 protein affects the reaction [Paraquat results in increased expression of PARP1 protein]]; 3-methyladenine affects the reaction [Paraquat affects the reaction [MYD88 protein affects the expression of BECN1 protein]]; 3-methyladenine affects the reaction [Paraquat affects the reaction [MYD88 protein affects the expression of SQSTM1 protein]]; 3-methyladenine affects the reaction [Paraquat affects the reaction [MYD88 protein affects the lipidation of MAP1LC3B protein]]; 3-methyladenine affects the reaction [Paraquat affects the reaction [MYD88 protein affects the phosphorylation of TP53 protein]]; [MYD88 protein affects the susceptibility to Paraquat] which affects the activity of CAT protein; [MYD88 protein affects the susceptibility to Paraquat] which affects the expression of BECN1 mRNA; [MYD88 protein affects the susceptibility to Paraquat] which affects the expression of DCTN4 mRNA; [MYD88 protein affects the susceptibility to Paraquat] which affects the expression of GPX1 mRNA; [MYD88 protein affects the susceptibility to Paraquat] which affects the expression of GPX1 protein; [MYD88 protein affects the susceptibility to Paraquat] which affects the expression of SOD1 mRNA; [MYD88 protein affects the susceptibility to Paraquat] which affects the expression of SOD1 protein; MYD88 protein affects the reaction [Paraquat affects the expression of FIS1 protein]; MYD88 protein affects the reaction [Paraquat affects the expression of OPA1 protein]; MYD88 protein affects the reaction [Paraquat results in decreased expression of BCL2 protein]; MYD88 protein affects the reaction [Paraquat results in decreased expression of BCL2L1 mRNA]; MYD88 protein affects the reaction [Paraquat results in decreased expression of MKI67 protein]; MYD88 protein affects the reaction [Paraquat results in decreased expression of OPA1 mRNA]; MYD88 protein affects the reaction [Paraquat results in decreased expression of TOMM20 protein]; MYD88 protein affects the reaction [Paraquat results in decreased phosphorylation of MTOR protein]; MYD88 protein affects the reaction [Paraquat results in increased activity of and results in increased cleavage of CASP3 protein]; MYD88 protein affects the reaction [Paraquat results in increased expression of CASP3 mRNA]; MYD88 protein affects the reaction [Paraquat results in increased expression of CDK2 protein]; MYD88 protein affects the reaction [Paraquat results in increased expression of DNM1L mRNA]; MYD88 protein affects the reaction [Paraquat results in increased expression of DNM1L protein]; MYD88 protein affects the reaction [Paraquat results in increased expression of FIS1 mRNA]; MYD88 protein affects the reaction [Paraquat results in increased expression of PARP1 protein]; Paraquat affects the reaction [MYD88 protein affects the expression of BECN1 protein]; Paraquat affects the reaction [MYD88 protein affects the expression of SQSTM1 protein]; Paraquat affects the reaction [MYD88 protein affects the lipidation of MAP1LC3B protein]; Paraquat affects the reaction [MYD88 protein affects the phosphorylation of TP53 protein]; Sirolimus affects the reaction [[MYD88 protein affects the susceptibility to Paraquat] which affects the expression of BECN1 mRNA]; Sirolimus affects the reaction [[MYD88 protein affects the susceptibility to Paraquat] which affects the expression of DCTN4 mRNA]; Sirolimus affects the reaction [[MYD88 protein affects the susceptibility to Paraquat] which affects the expression of GPX1 mRNA]; Sirolimus affects the reaction [[MYD88 protein affects the susceptibility to Paraquat] which affects the expression of SOD1 mRNA]; Sirolimus affects the reaction [MYD88 protein affects the reaction [Paraquat affects the expression of FIS1 protein]]; Sirolimus affects the reaction [MYD88 protein affects the reaction [Paraquat affects the expression of OPA1 protein]]; Sirolimus affects the reaction [MYD88 protein affects the reaction [Paraquat results in decreased expression of OPA1 mRNA]]; Sirolimus affects the reaction [MYD88 protein affects the reaction [Paraquat results in increased expression of DNM1L mRNA]]; Sirolimus affects the reaction [MYD88 protein affects the reaction [Paraquat results in increased expression of FIS1 mRNA]]; Sirolimus affects the reaction [Paraquat affects the reaction [MYD88 protein affects the expression of BECN1 protein]]; Sirolimus affects the reaction [Paraquat affects the reaction [MYD88 protein affects the expression of SQSTM1 protein]]; Sirolimus affects the reaction [Paraquat affects the reaction [MYD88 protein affects the lipidation of MAP1LC3B protein]]
MYD88 protein results in increased susceptibility to Paraquat

NCBI chr13:22,976,951...22,979,568
Ensembl chr13:22,966,137...22,983,109

G

nuclear receptor subfamily 1 group I member 3

multiple interactions
increases expression

Glutathione inhibits the reaction [Paraquat results in increased expression of NR1I3 mRNA]

NCBI chr 4:89,226,314...89,231,781
Ensembl chr 4:89,226,690...89,236,431

G

occludin

multiple interactions
decreases expression

Glutathione inhibits the reaction [Paraquat results in decreased expression of OCLN protein]

NCBI chr16:47,600,175...47,652,435
Ensembl chr16:47,600,212...47,654,033

G

OPA1 mitochondrial dynamin like GTPase

multiple interactions
decreases expression
affects expression

3-methyladenine affects the reaction [MYD88 protein affects the reaction [Paraquat results in decreased expression of OPA1 mRNA]]; MYD88 protein affects the reaction [Paraquat affects the expression of OPA1 protein]; MYD88 protein affects the reaction [Paraquat results in decreased expression of OPA1 mRNA]; Sirolimus affects the reaction [MYD88 protein affects the reaction [Paraquat affects the expression of OPA1 protein]]; Sirolimus affects the reaction [MYD88 protein affects the reaction [Paraquat results in decreased expression of OPA1 mRNA]]

NCBI chr13:130,624,771...130,718,345
Ensembl chr13:130,624,796...130,719,083

G

poly(ADP-ribose) polymerase 1

increases expression
multiple interactions

Paraquat results in increased expression of PARP1 protein
3-methyladenine affects the reaction [MYD88 protein affects the reaction [Paraquat results in increased expression of PARP1 protein]]; MYD88 protein affects the reaction [Paraquat results in increased expression of PARP1 protein]

NCBI chr10:14,203,157...14,241,164
Ensembl chr10:14,203,160...14,241,196

G

protein phosphatase 2 catalytic subunit alpha

increases expression

Paraquat results in increased expression of PPP2CA mRNA

NCBI chr 2:136,497,780...136,522,630
Ensembl chr 2:136,494,541...136,522,646

G

superoxide dismutase 1

increases expression
multiple interactions

Paraquat results in increased expression of SOD1 mRNA
3-methyladenine affects the reaction [[MYD88 protein affects the susceptibility to Paraquat] which affects the expression of SOD1 mRNA]; [MYD88 protein affects the susceptibility to Paraquat] which affects the expression of SOD1 mRNA; [MYD88 protein affects the susceptibility to Paraquat] which affects the expression of SOD1 protein; Sirolimus affects the reaction [[MYD88 protein affects the susceptibility to Paraquat] which affects the expression of SOD1 mRNA]

PMID:34811946 PMID:36615853

NCBI chr13:195,326,573...195,335,273
Ensembl chr13:195,326,649...195,337,729

G

superoxide dismutase 2

multiple interactions

[Glutathione co-treated with Paraquat] affects the expression of SOD2 mRNA

NCBI chr 1:7,679,352...7,689,564
Ensembl chr 1:7,679,352...7,689,560

G

sequestosome 1

multiple interactions

3-methyladenine affects the reaction [Paraquat affects the reaction [MYD88 protein affects the expression of SQSTM1 protein]]; Paraquat affects the reaction [MYD88 protein affects the expression of SQSTM1 protein]; Sirolimus affects the reaction [Paraquat affects the reaction [MYD88 protein affects the expression of SQSTM1 protein]]

NCBI chr 2:78,752,768...78,763,998
Ensembl chr 2:78,752,771...78,763,938

G

tight junction protein 1

decreases expression
multiple interactions

Paraquat results in decreased expression of TJP1 protein
Glutathione inhibits the reaction [Paraquat results in decreased expression of TJP1 protein]

NCBI chr 1:144,930,387...145,195,857
Ensembl chr 1:144,930,370...145,195,836

G

translocase of outer mitochondrial membrane 20

decreases expression
multiple interactions

Paraquat results in decreased expression of TOMM20 protein
3-methyladenine affects the reaction [MYD88 protein affects the reaction [Paraquat results in decreased expression of TOMM20 protein]]; MYD88 protein affects the reaction [Paraquat results in decreased expression of TOMM20 protein]

NCBI chr14:56,113,087...56,127,686
Ensembl chr14:56,113,192...56,127,677

G

tumor protein p53

multiple interactions

3-methyladenine affects the reaction [Paraquat affects the reaction [MYD88 protein affects the phosphorylation of TP53 protein]]; Paraquat affects the reaction [MYD88 protein affects the phosphorylation of TP53 protein]

NCBI chr12:52,939,643...52,953,786
Ensembl chr12:52,939,644...52,953,818

G

thioredoxin reductase 1

multiple interactions
decreases activity

Selenium inhibits the reaction [Paraquat results in decreased activity of TXNRD1 protein]

NCBI chr 5:80,170,334...80,213,889
Ensembl chr 5:80,172,260...80,236,219

phosphatidylcholine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 4

increases export
multiple interactions

ABCB4 protein results in increased export of Phosphatidylcholines
Itraconazole inhibits the reaction [ABCB4 protein results in increased export of Phosphatidylcholines]; Verapamil inhibits the reaction [ABCB4 protein results in increased export of Phosphatidylcholines]

NCBI chr 9:93,171,371...93,262,124

G

protein disulfide isomerase family A member 3

increases hydrolysis

PDIA3 protein results in increased hydrolysis of Phosphatidylcholines

NCBI chr 1:127,786,174...127,814,096
Ensembl chr 1:127,785,772...127,814,196

potassium chromate

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

glyceraldehyde-3-phosphate dehydrogenase

decreases activity

potassium chromate(VI) results in decreased activity of GAPDH protein

NCBI chr 5:64,129,678...64,135,194
Ensembl chr 5:64,129,679...64,133,991

potassium hexacyanoferrate(3-)

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

nitric oxide synthase 3

decreases activity

potassium ferricyanide results in decreased activity of NOS3 protein

NCBI chr18:6,209,218...6,228,912
Ensembl chr18:6,209,158...6,228,943

pralidoxime

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

acetylcholinesterase

multiple interactions

pralidoxime inhibits the reaction [Paraoxon results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [tabun results in decreased activity of ACHE protein]

PMID:20370537 PMID:20971170

NCBI chr 3:8,732,451...8,738,274
Ensembl chr 3:8,732,441...8,738,605

G

monoamine oxidase A

decreases activity

pralidoxime results in decreased activity of MAOA protein

NCBI chr X:38,930,452...39,006,220

G

monoamine oxidase B

decreases activity

pralidoxime results in decreased activity of MAOB protein

NCBI chr X:39,025,973...39,144,389
Ensembl chr X:39,025,970...39,144,345

Pyridostigmine bromide

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

acetylcholinesterase

decreases activity
multiple interactions

Pyridostigmine Bromide results in decreased activity of ACHE protein
Pyridostigmine Bromide inhibits the reaction [Soman results in decreased activity of ACHE protein]

NCBI chr 3:8,732,451...8,738,274
Ensembl chr 3:8,732,441...8,738,605

S-adenosyl-L-methioninate

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

catechol-O-methyltransferase

multiple interactions

[S-Adenosylmethionine analog co-treated with COMT protein] results in increased methylation of catechol

NCBI chr14:51,384,729...51,403,997
Ensembl chr14:51,385,738...51,403,998

sodium arsenite

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

AKT serine/threonine kinase 1

increases degradation
multiple interactions
decreases expression

sodium arsenite results in increased degradation of AKT1 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [sodium arsenite results in increased phosphorylation of AKT1 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [sodium arsenite results in increased degradation of AKT1 protein]; sodium arsenite results in decreased expression of and results in increased phosphorylation of AKT1 protein; Wortmannin inhibits the reaction [sodium arsenite results in increased phosphorylation of AKT1 protein]
sodium arsenite results in decreased expression of AKT1 protein

PMID:12760830 PMID:16239170

G

hypoxia inducible factor 1 subunit alpha

multiple interactions
increases expression

bisindolylmaleimide I inhibits the reaction [sodium arsenite results in increased expression of HIF1A mRNA]; Go 6976 inhibits the reaction [sodium arsenite results in increased expression of HIF1A mRNA]
sodium arsenite results in increased expression of HIF1A mRNA; sodium arsenite results in increased expression of HIF1A protein

NCBI chr 1:190,625,436...190,673,926
Ensembl chr 1:190,625,244...190,674,845

G

mitogen-activated protein kinase 6

increases expression

sodium arsenite results in increased expression of MAPK6 protein

NCBI chr 1:119,725,026...119,770,988
Ensembl chr 1:119,725,029...119,771,312

G

nitric oxide synthase 3

multiple interactions
increases degradation
decreases expression

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [sodium arsenite results in increased phosphorylation of NOS3 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [sodium arsenite results in increased degradation of NOS3 protein]; sodium arsenite results in increased phosphorylation of and results in decreased activity of NOS3 protein; Wortmannin inhibits the reaction [sodium arsenite results in increased phosphorylation of NOS3 protein]
sodium arsenite results in decreased expression of NOS3 protein

NCBI chr18:6,209,218...6,228,912
Ensembl chr18:6,209,158...6,228,943

G

protein kinase cAMP-activated catalytic subunit alpha

decreases expression

sodium arsenite results in decreased expression of PRKACA protein

NCBI chr 2:65,074,876...65,095,564
Ensembl chr 2:65,074,870...65,095,551

G

protein kinase C delta

increases phosphorylation

sodium arsenite results in increased phosphorylation of PRKCD protein

NCBI chr13:35,290,835...35,323,245
Ensembl chr13:35,290,610...35,323,356

G

ribosomal protein S6 kinase A1

decreases expression

sodium arsenite results in decreased expression of RPS6KA1 protein

NCBI chr 6:83,905,124...83,947,189
Ensembl chr 6:83,905,077...83,950,963

G

superoxide dismutase 1

multiple interactions
increases activity

[sodium arsenite results in increased activity of SOD1 protein] which results in increased abundance of Hydrogen Peroxide

NCBI chr13:195,326,573...195,335,273
Ensembl chr13:195,326,649...195,337,729

G

tumor protein p53

increases expression

sodium arsenite results in increased expression of TP53

NCBI chr12:52,939,643...52,953,786
Ensembl chr12:52,939,644...52,953,818

G

vascular endothelial growth factor A

increases expression
multiple interactions

sodium arsenite results in increased expression of VEGFA mRNA
bisindolylmaleimide I inhibits the reaction [sodium arsenite results in increased expression of VEGFA mRNA]; R 59949 promotes the reaction [sodium arsenite results in increased expression of VEGFA mRNA]; sodium arsenite results in increased expression of and results in increased secretion of VEGFA protein

NCBI chr 7:38,746,393...38,762,282
Ensembl chr 7:38,746,052...38,761,366

sodium benzoate

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

D-amino acid oxidase

decreases activity

Sodium Benzoate results in decreased activity of DAO protein

NCBI chr14:41,931,549...41,950,628
Ensembl chr14:41,931,541...41,950,633

sodium borohydride

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

chemokine (C-C motif) ligand 2

multiple interactions

sodium borohydride inhibits the reaction [[2,2'-azobis(2-amidinopropane) results in increased oxidation of Docosahexaenoic Acids] inhibits the reaction [3,4,3',4'-tetrachlorobiphenyl results in increased expression of CCL2 mRNA]]

NCBI chr12:40,798,109...40,800,013
Ensembl chr12:40,798,109...40,800,026

sodium dichromate

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

AKT serine/threonine kinase 1

decreases expression

sodium bichromate results in decreased expression of AKT1 protein

sodium disulfite

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

C-X-C motif chemokine ligand 8

multiple interactions

sodium metabisulfite inhibits the reaction [deoxynivalenol results in increased expression of CXCL8 mRNA]

NCBI chr 8:69,932,646...69,935,861
Ensembl chr 8:69,932,643...69,935,861

G

interleukin 6

multiple interactions

sodium metabisulfite inhibits the reaction [deoxynivalenol results in increased expression of IL6 mRNA]

NCBI chr 9:91,506,421...91,510,830
Ensembl chr 9:91,506,421...91,511,263

sodium hydrogencarbonate

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

glyceraldehyde-3-phosphate dehydrogenase

multiple interactions

[Sodium Bicarbonate co-treated with Calcium Chloride] results in increased activity of GAPDH protein

NCBI chr 5:64,129,678...64,135,194
Ensembl chr 5:64,129,679...64,133,991

sodium iodide

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

solute carrier family 5 member 5

multiple interactions
increases uptake

sodium perchlorate inhibits the reaction [SLC5A5 protein alternative form results in increased uptake of Sodium Iodide]; sodium perchlorate inhibits the reaction [SLC5A5 protein results in increased uptake of Sodium Iodide]
SLC5A5 protein alternative form results in increased uptake of Sodium Iodide; SLC5A5 protein results in increased uptake of Sodium Iodide

NCBI chr 2:59,869,157...59,885,086
Ensembl chr 2:59,869,155...59,885,266

sodium perchlorate

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

solute carrier family 5 member 5

multiple interactions

sodium perchlorate inhibits the reaction [SLC5A5 protein alternative form results in increased uptake of Sodium Iodide]; sodium perchlorate inhibits the reaction [SLC5A5 protein results in increased uptake of Sodium Iodide]

NCBI chr 2:59,869,157...59,885,086
Ensembl chr 2:59,869,155...59,885,266

G

thyroid peroxidase

decreases activity

sodium perchlorate results in decreased activity of TPO protein

NCBI chr 3:132,384,677...132,409,750
Ensembl chr 3:132,384,583...132,409,208

superoxide

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

metallothionein 3

multiple interactions

MT3 protein binds to and affects the metabolism of Superoxides

NCBI chr 6:18,634,735...18,636,134
Ensembl chr 6:18,634,261...18,636,131

G

protein kinase cGMP-dependent 1

multiple interactions

Superoxides affects the reaction [Nitroglycerin results in increased activity of PRKG1 protein]

NCBI chr14:97,558,531...98,793,080
Ensembl chr14:97,558,533...98,793,010

G

xanthine dehydrogenase

multiple interactions

[Hypoxanthine co-treated with XDH protein] results in increased chemical synthesis of Superoxides

NCBI chr 3:107,987,060...108,052,043
Ensembl chr 3:107,987,126...108,053,169

tetraethylammonium

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

solute carrier family 22 member 2

increases uptake
multiple interactions

SLC22A2 protein results in increased uptake of Tetraethylammonium
Quercetin inhibits the reaction [SLC22A2 protein results in increased uptake of Tetraethylammonium]; Rutin inhibits the reaction [SLC22A2 protein results in increased uptake of Tetraethylammonium]

NCBI chr 1:7,289,278...7,323,418
Ensembl chr 1:7,289,831...7,323,146

thymol sulfate(1-)

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ryanodine receptor 1

increases activity

Thymol results in increased activity of RYR1 protein

NCBI chr 6:47,339,759...47,458,457
Ensembl chr 6:47,343,768...47,458,458

zinc acetate

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

annexin A5

multiple interactions

Zinc Acetate inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [Linoleic Acid promotes the reaction [TNF protein results in increased activity of ANXA5 protein]]]; Zinc Acetate inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [TNF protein promotes the reaction [Linoleic Acid results in increased activity of ANXA5 protein]]]

NCBI chr 8:102,387,833...102,420,868
Ensembl chr 8:102,388,103...102,425,750

G

caspase 3

multiple interactions

Zinc Acetate inhibits the reaction [Linoleic Acid results in increased activity of CASP3 protein]; Zinc Acetate inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [Linoleic Acid promotes the reaction [TNF protein results in increased activity of CASP3 protein]]]; Zinc Acetate inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [Linoleic Acid results in increased activity of CASP3 protein]]; Zinc Acetate inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [TNF protein results in increased activity of CASP3 protein]]; Zinc Acetate promotes the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [TNF protein promotes the reaction [Linoleic Acid results in increased activity of CASP3 protein]]]

NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,751...45,764,213

G

peroxisome proliferator activated receptor alpha

multiple interactions

Zinc Acetate inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of PPARA mRNA]

NCBI chr 5:3,302,755...3,321,091
Ensembl chr 5:3,300,741...3,364,239

G

prostaglandin-endoperoxide synthase 2

multiple interactions

Zinc Acetate inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of PTGS2 mRNA]

NCBI chr 9:127,850,164...127,858,866
Ensembl chr 9:127,850,015...127,858,884

G

selectin E

multiple interactions

Zinc Acetate inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of SELE mRNA]

NCBI chr 4:81,289,061...81,299,657

G

tumor necrosis factor

multiple interactions

Zinc Acetate inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [Linoleic Acid promotes the reaction [TNF protein results in increased activity of ANXA5 protein]]]; Zinc Acetate inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [Linoleic Acid promotes the reaction [TNF protein results in increased activity of CASP3 protein]]]; Zinc Acetate inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [TNF protein promotes the reaction [Linoleic Acid results in increased activity of ANXA5 protein]]]; Zinc Acetate inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [TNF protein results in increased activity of CASP3 protein]]; Zinc Acetate promotes the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [TNF protein promotes the reaction [Linoleic Acid results in increased activity of CASP3 protein]]]

NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,628...23,702,416

zinc dichloride

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

porcine seminal protein I

multiple interactions
affects folding

zinc chloride promotes the reaction [PSP-I protein binds to Heparin]
zinc chloride affects the folding of PSP-I protein

NCBI chr14:132,302,376...132,309,388
Ensembl chr14:132,302,352...132,308,106

zinc sulfate

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

BCL2 associated X, apoptosis regulator

increases expression
multiple interactions

Zinc Sulfate results in increased expression of BAX mRNA
3-methyladenine inhibits the reaction [Zinc Sulfate results in increased expression of BAX mRNA]

NCBI chr 6:54,222,341...54,228,150
Ensembl chr 6:54,222,336...54,228,140

G

beclin 1

increases expression
multiple interactions

Zinc Sulfate results in increased expression of BECN1 protein
3-methyladenine inhibits the reaction [Zinc Sulfate results in increased expression of BECN1 protein]

NCBI chr12:20,041,914...20,054,249
Ensembl chr12:20,041,956...20,054,373

G

caspase 3

multiple interactions
increases expression
increases cleavage

3-methyladenine inhibits the reaction [Zinc Sulfate results in increased cleavage of CASP3 protein]
Zinc Sulfate results in increased expression of CASP3 mRNA

NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,751...45,764,213

G

caspase 6

increases expression

Zinc Sulfate results in increased expression of CASP6 mRNA

NCBI chr 8:112,519,450...112,534,315
Ensembl chr 8:112,520,629...112,537,045

G

caspase 8

multiple interactions
increases cleavage

3-methyladenine inhibits the reaction [Zinc Sulfate results in increased cleavage of CASP8 protein]

NCBI chr15:104,923,659...104,948,470
Ensembl chr15:104,923,953...104,948,468

G

cytochrome c, somatic

increases expression
multiple interactions

Zinc Sulfate results in increased expression of CYCS mRNA
3-methyladenine inhibits the reaction [Zinc Sulfate results in increased expression of CYCS mRNA]

NCBI chr18:47,169,921...47,172,212
Ensembl chr18:47,169,866...47,173,866

G

glutathione peroxidase 1

multiple interactions

Zinc Sulfate inhibits the reaction [Diquat results in decreased expression of GPX1 mRNA]

NCBI chr13:31,916,269...31,917,337
Ensembl chr13:31,916,246...31,917,433

G

interleukin-1 beta-like

multiple interactions

Zinc Sulfate inhibits the reaction [Diquat results in increased expression of IL1B mRNA]

G

microtubule associated protein 1 light chain 3 alpha

increases expression

Zinc Sulfate results in increased expression of MAP1LC3A mRNA

NCBI chr17:37,957,830...37,959,505
Ensembl chr17:37,957,507...37,959,505

G

metallothionein 1A

increases expression

Zinc Sulfate results in increased expression of MT1A mRNA

NCBI chr 6:18,672,016...18,673,673
Ensembl chr 6:18,672,001...18,673,672

G

NFE2 like bZIP transcription factor 2

multiple interactions

Zinc Sulfate inhibits the reaction [Diquat results in decreased expression of NFE2L2 mRNA]

NCBI chr15:82,967,485...83,146,185
Ensembl chr15:82,973,656...83,146,183

G

solute carrier family 30 member 1

increases expression

Zinc Sulfate results in increased expression of SLC30A1 mRNA

NCBI chr 9:131,633,586...131,636,934
Ensembl chr 9:131,633,585...131,640,672

G

solute carrier family 39 member 10

decreases expression
increases expression

Zinc Sulfate results in decreased expression of SLC39A10 mRNA
Zinc Sulfate results in increased expression of SLC39A10 mRNA

NCBI chr15:99,584,830...99,724,621
Ensembl chr15:99,584,872...99,724,611

G

superoxide dismutase 1

multiple interactions

Zinc Sulfate inhibits the reaction [Diquat results in decreased expression of SOD1 mRNA]

NCBI chr13:195,326,573...195,335,273
Ensembl chr13:195,326,649...195,337,729

G

sequestosome 1

increases expression
multiple interactions
decreases expression

Zinc Sulfate results in increased expression of SQSTM1 mRNA
3-methyladenine inhibits the reaction [Zinc Sulfate results in decreased expression of SQSTM1 protein]

NCBI chr 2:78,752,768...78,763,998
Ensembl chr 2:78,752,771...78,763,938

G

tumor necrosis factor

multiple interactions

Zinc Sulfate inhibits the reaction [Diquat results in increased expression of TNF mRNA]

NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,628...23,702,416

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	5052
chemical entity	5080
molecular entity	5051
ion	168
anion +	109
cation +	161
inorganic ion +	130
monoatomic ion +	99
organic ion +	107
polyatomic ion +	81
radical ion +	3
silicon(2+)	0
titanium(3+)	0

paths to the root