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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:insect growth regulator
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Accession:CHEBI:24851 term browser browse the term
Definition:A growth regulator that inhibits the life cycle of an insect.
Synonyms:related_synonym: insect growth regulators


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azadirachtin A term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acp5 acid phosphatase 5, tartrate resistant multiple interactions
decreases expression		 EXP azadirachtin inhibits the reaction [Estrogens deficiency results in increased expression of ACP5 mRNA]
azadirachtin results in decreased expression of ACP5 mRNA		 CTD PMID:31225646 NCBI chr 9:22,038,023...22,047,042
Ensembl chr 9:22,038,023...22,047,007 		JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 increases expression ISO azadirachtin results in increased expression of APAF1 protein CTD PMID:20429769 NCBI chr10:90,825,173...90,918,688
Ensembl chr10:90,825,173...90,918,632 		JBrowse link
G Bad BCL2-associated agonist of cell death increases expression ISO azadirachtin results in increased expression of BAD mRNA CTD PMID:20429769 NCBI chr19:6,919,229...6,929,273
Ensembl chr19:6,919,229...6,929,267 		JBrowse link
G Bax BCL2-associated X protein increases expression ISO azadirachtin results in increased expression of BAX mRNA CTD PMID:20429769 NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322 		JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 decreases expression ISO azadirachtin results in decreased expression of BCL2 mRNA; azadirachtin results in decreased expression of BCL2 protein CTD PMID:20429769 NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004 		JBrowse link
G Bcl2l1 BCL2-like 1 decreases expression ISO azadirachtin results in decreased expression of BCL2L1 mRNA CTD PMID:20429769 NCBI chr 2:152,600,652...152,673,632
Ensembl chr 2:152,622,588...152,673,648 		JBrowse link
G Bglap bone gamma carboxyglutamate protein multiple interactions EXP azadirachtin inhibits the reaction [Estrogens deficiency results in increased expression of BGLAP protein] CTD PMID:31225646 NCBI chr 3:88,290,802...88,291,773
Ensembl chr 3:88,290,808...88,291,771 		JBrowse link
G Bid BH3 interacting domain death agonist increases expression ISO azadirachtin results in increased expression of BID mRNA CTD PMID:20429769 NCBI chr 6:120,870,080...120,894,074
Ensembl chr 6:120,868,891...120,893,814 		JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 decreases expression ISO azadirachtin results in decreased expression of BIRC5 protein CTD PMID:20429769 NCBI chr11:117,740,063...117,746,569
Ensembl chr11:117,740,077...117,746,569 		JBrowse link
G Bmp2 bone morphogenetic protein 2 increases expression EXP azadirachtin results in increased expression of BMP2 mRNA; azadirachtin results in increased expression of BMP2 protein CTD PMID:31225646 NCBI chr 2:133,394,079...133,404,816
Ensembl chr 2:133,394,079...133,404,805 		JBrowse link
G Casp3 caspase 3 increases expression ISO azadirachtin results in increased expression of CASP3 mRNA; azadirachtin results in increased expression of CASP3 protein CTD PMID:20429769 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724 		JBrowse link
G Casp6 caspase 6 increases expression ISO azadirachtin results in increased expression of CASP6 protein CTD PMID:20429769 NCBI chr 3:129,695,064...129,707,761
Ensembl chr 3:129,695,074...129,707,752 		JBrowse link
G Casp8 caspase 8 increases expression ISO azadirachtin results in increased expression of CASP8 protein CTD PMID:20429769 NCBI chr 1:58,834,553...58,886,663
Ensembl chr 1:58,834,533...58,886,662 		JBrowse link
G Casp9 caspase 9 increases expression ISO azadirachtin results in increased expression of CASP9 mRNA; azadirachtin results in increased expression of CASP9 protein CTD PMID:20429769 NCBI chr 4:141,520,923...141,543,289
Ensembl chr 4:141,520,923...141,543,287 		JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO azadirachtin results in decreased expression of CCND1 mRNA CTD PMID:20429769 NCBI chr 7:144,483,668...144,493,568
Ensembl chr 7:144,483,668...144,493,662 		JBrowse link
G Cdkn1a cyclin dependent kinase inhibitor 1A increases expression ISO azadirachtin results in increased expression of CDKN1A mRNA; azadirachtin results in increased expression of CDKN1A protein CTD PMID:20429769 NCBI chr17:29,309,953...29,319,696
Ensembl chr17:29,309,950...29,319,701 		JBrowse link
G Cycs cytochrome c, somatic affects localization
increases expression		 ISO azadirachtin affects the localization of CYCS protein
azadirachtin results in increased expression of CYCS mRNA		 CTD PMID:20429769 NCBI chr 6:50,539,543...50,543,549
Ensembl chr 6:50,539,543...50,543,518 		JBrowse link
G Esr1 estrogen receptor 1 (alpha) affects binding
multiple interactions
increases expression		 ISO
EXP		 azadirachtin binds to ESR1 protein
1,3-bis(4-hydroxyphenyl)-4-methyl-5-(4-(2-piperidinylethoxy)phenol)-1H-pyrazole inhibits the reaction [azadirachtin results in increased expression of ESR1 mRNA]; 1,3-bis(4-hydroxyphenyl)-4-methyl-5-(4-(2-piperidinylethoxy)phenol)-1H-pyrazole inhibits the reaction [azadirachtin results in increased expression of ESR1 protein]; azadirachtin inhibits the reaction [Estrogens deficiency results in decreased expression of ESR1 mRNA]; ESR1 protein promotes the reaction [azadirachtin results in increased expression of RUNX2 mRNA]; ESR1 protein promotes the reaction [azadirachtin results in increased expression of RUNX2 protein]
azadirachtin results in increased expression of ESR1 mRNA; azadirachtin results in increased expression of ESR1 protein		 CTD PMID:31225646 NCBI chr10:4,561,989...4,955,633
Ensembl chr10:4,561,593...4,955,614 		JBrowse link
G Esr2 estrogen receptor 2 (beta) affects binding
multiple interactions
increases expression		 ISO
EXP		 azadirachtin binds to ESR2 protein
azadirachtin inhibits the reaction [Estrogens deficiency results in decreased expression of ESR2 mRNA]
azadirachtin results in increased expression of ESR2 mRNA; azadirachtin results in increased expression of ESR2 protein		 CTD PMID:31225646 NCBI chr12:76,167,193...76,224,033
Ensembl chr12:76,167,193...76,224,033 		JBrowse link
G Ikbkb inhibitor of kappaB kinase beta decreases expression ISO azadirachtin results in decreased expression of IKBKB protein CTD PMID:20429769 NCBI chr 8:23,149,228...23,196,605
Ensembl chr 8:23,149,228...23,196,605 		JBrowse link
G Mapk1 mitogen-activated protein kinase 1 increases phosphorylation EXP azadirachtin results in increased phosphorylation of MAPK1 protein CTD PMID:31225646 NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317 		JBrowse link
G Mapk3 mitogen-activated protein kinase 3 increases phosphorylation EXP azadirachtin results in increased phosphorylation of MAPK3 protein CTD PMID:31225646 NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991 		JBrowse link
G Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 decreases expression ISO azadirachtin results in decreased expression of NFKB1 protein CTD PMID:20429769 NCBI chr 3:135,290,416...135,397,422
Ensembl chr 3:135,290,416...135,397,308 		JBrowse link
G Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha decreases expression ISO azadirachtin results in decreased expression of NFKBIA protein modified form CTD PMID:20429769 NCBI chr12:55,536,194...55,539,432
Ensembl chr12:55,536,195...55,539,432 		JBrowse link
G Pcna proliferating cell nuclear antigen decreases expression ISO azadirachtin results in decreased expression of PCNA mRNA; azadirachtin results in decreased expression of PCNA protein CTD PMID:20429769 NCBI chr 2:132,091,206...132,095,100
Ensembl chr 2:132,091,082...132,095,234 		JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) decreases expression ISO azadirachtin results in decreased expression of RELA protein CTD PMID:20429769 NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158 		JBrowse link
G Runx2 runt related transcription factor 2 multiple interactions
increases expression		 EXP ESR1 protein promotes the reaction [azadirachtin results in increased expression of RUNX2 mRNA]; ESR1 protein promotes the reaction [azadirachtin results in increased expression of RUNX2 protein]
azadirachtin results in increased expression of RUNX2 mRNA; azadirachtin results in increased expression of RUNX2 protein		 CTD PMID:31225646 NCBI chr17:44,806,873...45,125,518
Ensembl chr17:44,806,874...45,125,684 		JBrowse link
G Smad1 SMAD family member 1 increases expression EXP azadirachtin results in increased expression of SMAD1 protein modified form CTD PMID:31225646 NCBI chr 8:80,065,024...80,126,057
Ensembl chr 8:80,065,024...80,126,147 		JBrowse link
G Tnf tumor necrosis factor decreases expression EXP azadirachtin results in decreased expression of TNF mRNA CTD PMID:31225646 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
G Tnfrsf11a tumor necrosis factor receptor superfamily, member 11a, NFKB activator decreases expression
multiple interactions		 EXP azadirachtin results in decreased expression of TNFRSF11A mRNA
azadirachtin inhibits the reaction [Estrogens deficiency results in increased expression of TNFRSF11A mRNA]		 CTD PMID:31225646 NCBI chr 1:105,708,443...105,777,172
Ensembl chr 1:105,708,443...105,775,709 		JBrowse link
G Trp53 transformation related protein 53 increases expression ISO azadirachtin results in increased expression of TP53 mRNA; azadirachtin results in increased expression of TP53 protein CTD PMID:20429769 NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699 		JBrowse link
buprofezin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aen apoptosis enhancing nuclease increases expression ISO buprofezin results in increased expression of AEN mRNA CTD PMID:36287832 NCBI chr 7:78,545,675...78,560,957
Ensembl chr 7:78,545,602...78,560,957 		JBrowse link
G Aifm1 apoptosis-inducing factor, mitochondrion-associated 1 increases expression ISO buprofezin results in increased expression of AIFM1 mRNA CTD PMID:36287832 NCBI chr  X:47,563,821...47,602,440
Ensembl chr  X:47,563,821...47,602,440 		JBrowse link
G Aifm3 apoptosis-inducing factor, mitochondrion-associated 3 increases expression ISO buprofezin results in increased expression of AIFM3 mRNA CTD PMID:36287832 NCBI chr16:17,307,418...17,325,349
Ensembl chr16:17,307,475...17,325,349 		JBrowse link
G Ambra1 autophagy/beclin 1 regulator 1 increases expression ISO buprofezin results in increased expression of AMBRA1 mRNA CTD PMID:36287832 NCBI chr 2:91,560,464...91,749,194
Ensembl chr 2:91,560,479...91,749,194 		JBrowse link
G Atg10 autophagy related 10 increases expression ISO buprofezin results in increased expression of ATG10 mRNA CTD PMID:36287832 NCBI chr13:91,083,467...91,372,189
Ensembl chr13:91,083,475...91,372,087 		JBrowse link
G Atg12 autophagy related 12 increases expression ISO buprofezin results in increased expression of ATG12 mRNA CTD PMID:36287832 NCBI chr18:46,865,484...46,874,683
Ensembl chr18:46,863,211...46,874,647 		JBrowse link
G Atg5 autophagy related 5 increases expression ISO buprofezin results in increased expression of ATG5 mRNA CTD PMID:36287832 NCBI chr10:44,144,325...44,240,295
Ensembl chr10:44,144,354...44,240,287 		JBrowse link
G Atg7 autophagy related 7 increases expression ISO buprofezin results in increased expression of ATG7 mRNA CTD PMID:36287832 NCBI chr 6:114,620,075...114,837,565
Ensembl chr 6:114,620,058...114,837,575 		JBrowse link
G Atp2b4 ATPase, Ca++ transporting, plasma membrane 4 decreases expression ISO buprofezin results in decreased expression of ATP2B4 mRNA CTD PMID:36287832 NCBI chr 1:133,630,416...133,728,755
Ensembl chr 1:133,627,195...133,728,779 		JBrowse link
G Bax BCL2-associated X protein increases expression ISO buprofezin results in increased expression of BAX protein CTD PMID:36287832 NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322 		JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 decreases expression ISO buprofezin results in decreased expression of BCL2 mRNA; buprofezin results in decreased expression of BCL2 protein CTD PMID:36287832 NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004 		JBrowse link
G Becn1 beclin 1, autophagy related increases expression ISO buprofezin results in increased expression of BECN1 protein CTD PMID:36287832 NCBI chr11:101,179,084...101,193,112
Ensembl chr11:101,176,778...101,193,112 		JBrowse link
G Bok BCL2-related ovarian killer increases expression ISO buprofezin results in increased expression of BOK mRNA CTD PMID:36287832 NCBI chr 1:93,613,297...93,623,492
Ensembl chr 1:93,613,382...93,623,486 		JBrowse link
G Caap1 caspase activity and apoptosis inhibitor 1 decreases expression ISO buprofezin results in decreased expression of CAAP1 mRNA CTD PMID:36287832 NCBI chr 4:94,388,318...94,445,033
Ensembl chr 4:94,388,318...94,445,033 		JBrowse link
G Casp3 caspase 3 increases activity ISO buprofezin results in increased activity of CASP3 protein CTD PMID:36287832 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724 		JBrowse link
G Casp9 caspase 9 increases activity ISO buprofezin results in increased activity of CASP9 protein CTD PMID:36287832 NCBI chr 4:141,520,923...141,543,289
Ensembl chr 4:141,520,923...141,543,287 		JBrowse link
G Cat catalase decreases activity EXP buprofezin results in decreased activity of CAT protein CTD PMID:31199169 NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505 		JBrowse link
G Cyct cytochrome c, testis increases localization ISO buprofezin results in increased localization of CYCT protein CTD PMID:36287832 NCBI chr 2:76,184,286...76,190,797
Ensembl chr 2:76,184,286...76,190,794 		JBrowse link
G Got1 glutamic-oxaloacetic transaminase 1, soluble increases expression EXP buprofezin results in increased expression of GOT1 protein CTD PMID:31199169 NCBI chr19:43,488,191...43,514,743
Ensembl chr19:43,488,191...43,513,044 		JBrowse link
G Gpt glutamic pyruvic transaminase, soluble increases expression EXP buprofezin results in increased expression of GPT protein CTD PMID:31199169 NCBI chr15:76,580,926...76,583,875
Ensembl chr15:76,579,916...76,583,886 		JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions ISO buprofezin results in increased lipidation of and results in increased localization of MAP1LC3B protein CTD PMID:36287832 NCBI chr 8:122,317,177...122,325,499
Ensembl chr 8:122,317,100...122,325,499 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases activity ISO buprofezin results in increased activity of NR1I3 protein CTD PMID:28927721 NCBI chr 1:171,041,503...171,046,414
Ensembl chr 1:171,041,539...171,048,270 		JBrowse link
G Rara retinoic acid receptor, alpha increases activity ISO buprofezin results in increased activity of RARA protein CTD PMID:20143881 NCBI chr11:98,818,626...98,865,768
Ensembl chr11:98,818,644...98,865,768 		JBrowse link
G Sod1 superoxide dismutase 1, soluble decreases activity EXP buprofezin results in decreased activity of SOD1 protein CTD PMID:31199169 NCBI chr16:90,017,650...90,023,221
Ensembl chr16:90,017,642...90,023,217 		JBrowse link
G Sqstm1 sequestosome 1 decreases expression ISO buprofezin results in decreased expression of SQSTM1 protein CTD PMID:36287832 NCBI chr11:50,090,979...50,105,303
Ensembl chr11:50,090,193...50,101,654 		JBrowse link
G Triap1 TP53 regulated inhibitor of apoptosis 1 decreases expression ISO buprofezin results in decreased expression of TRIAP1 mRNA CTD PMID:36287832 NCBI chr 5:115,479,290...115,481,612
Ensembl chr 5:115,479,284...115,481,628 		JBrowse link
chlorfluazuron term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2a5 cytochrome P450, family 2, subfamily a, polypeptide 5 increases expression ISO chlorfluazuron results in increased expression of CYP2A6 mRNA CTD PMID:22310298 NCBI chr 7:26,534,764...26,542,689
Ensembl chr 7:26,534,730...26,542,973 		JBrowse link
G Cyp2b10 cytochrome P450, family 2, subfamily b, polypeptide 10 increases expression
increases activity		 ISO chlorfluazuron results in increased expression of CYP2B6 mRNA
chlorfluazuron results in increased activity of CYP2B6 protein		 CTD PMID:22310298 NCBI chr 7:25,597,083...25,626,049
Ensembl chr 7:25,597,045...25,626,049 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions
decreases activity		 ISO chlorfluazuron inhibits the reaction [CYP2E1 protein results in increased hydroxylation of Chlorzoxazone]
chlorfluazuron results in decreased activity of CYP2E1 protein		 CTD PMID:22634058 NCBI chr 7:140,343,732...140,354,903
Ensembl chr 7:140,343,652...140,354,900 		JBrowse link
diflubenzuron term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression ISO Diflubenzuron results in increased expression of CYP1A1 protein CTD PMID:8812189 NCBI chr 9:57,595,211...57,611,107
Ensembl chr 9:57,595,211...57,611,107 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 affects binding ISO Diflubenzuron binds to CYP1A2 protein CTD PMID:32278787 NCBI chr 9:57,584,220...57,590,938
Ensembl chr 9:57,584,220...57,590,986 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity ISO Diflubenzuron results in increased activity of NR1I2 protein CTD PMID:16565514 NCBI chr16:38,068,711...38,115,211
Ensembl chr16:38,068,685...38,115,186 		JBrowse link
fenoxycarb term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP-binding cassette, sub-family B member 1A multiple interactions
decreases activity		 ISO fenoxycarb inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]
fenoxycarb results in decreased activity of ABCB1 protein		 CTD PMID:21783720 NCBI chr 5:8,617,091...8,798,575
Ensembl chr 5:8,710,077...8,798,575 		JBrowse link
G Ache acetylcholinesterase decreases activity ISO fenoxycarb results in decreased activity of ACHE protein CTD PMID:14644616 NCBI chr 5:137,286,516...137,292,728
Ensembl chr 5:137,285,781...137,292,728 		JBrowse link
G Chrna3 cholinergic receptor, nicotinic, alpha polypeptide 3 multiple interactions ISO fenoxycarb results in decreased activity of [CHRNA3 protein binds to CHRNB2 protein]; fenoxycarb results in decreased activity of [CHRNA3 protein binds to CHRNB4 protein] CTD PMID:14644616 NCBI chr 9:54,917,401...54,933,846
Ensembl chr 9:54,917,395...54,933,846 		JBrowse link
G Chrna4 cholinergic receptor, nicotinic, alpha polypeptide 4 multiple interactions ISO fenoxycarb results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]; fenoxycarb results in decreased activity of [CHRNA4 protein binds to CHRNB4 protein] CTD PMID:14644616 NCBI chr 2:180,664,104...180,685,339
Ensembl chr 2:180,660,173...180,685,339 		JBrowse link
G Chrnb2 cholinergic receptor nicotinic beta 2 subunit multiple interactions ISO fenoxycarb results in decreased activity of [CHRNA3 protein binds to CHRNB2 protein]; fenoxycarb results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein] CTD PMID:14644616 NCBI chr 3:89,660,755...89,671,939
Ensembl chr 3:89,653,502...89,671,939 		JBrowse link
G Chrnb4 cholinergic receptor, nicotinic, beta polypeptide 4 multiple interactions ISO fenoxycarb results in decreased activity of [CHRNA3 protein binds to CHRNB4 protein]; fenoxycarb results in decreased activity of [CHRNA4 protein binds to CHRNB4 protein] CTD PMID:14644616 NCBI chr 9:54,935,438...54,956,236
Ensembl chr 9:54,935,438...54,956,063 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases activity ISO fenoxycarb results in increased activity of NR1I3 protein CTD PMID:28927721 NCBI chr 1:171,041,503...171,046,414
Ensembl chr 1:171,041,539...171,048,270 		JBrowse link
flufenoxuron term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 thymoma viral proto-oncogene 1 increases phosphorylation
multiple interactions		 EXP flufenoxuron results in increased phosphorylation of AKT1 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [flufenoxuron results in increased phosphorylation of AKT1 protein]; pyrazolanthrone inhibits the reaction [flufenoxuron results in increased phosphorylation of AKT1 protein]		 CTD PMID:33771252 NCBI chr12:112,620,260...112,641,266
Ensembl chr12:112,620,255...112,641,318 		JBrowse link
G Ar androgen receptor decreases expression EXP flufenoxuron results in decreased expression of AR mRNA CTD PMID:33771252 NCBI chr  X:97,192,363...97,366,824
Ensembl chr  X:97,192,375...97,366,821 		JBrowse link
G Bad BCL2-associated agonist of cell death decreases phosphorylation EXP flufenoxuron results in decreased phosphorylation of BAD protein CTD PMID:33771252 NCBI chr19:6,919,229...6,929,273
Ensembl chr19:6,919,229...6,929,267 		JBrowse link
G Bak1 BCL2-antagonist/killer 1 increases expression EXP flufenoxuron results in increased expression of BAK1 protein CTD PMID:33771252 NCBI chr17:27,238,786...27,247,601
Ensembl chr17:27,238,784...27,247,983 		JBrowse link
G Bcl2l1 BCL2-like 1 decreases expression EXP flufenoxuron results in decreased expression of BCL2L1 protein CTD PMID:33771252 NCBI chr 2:152,600,652...152,673,632
Ensembl chr 2:152,622,588...152,673,648 		JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 increases expression EXP flufenoxuron results in increased expression of CYP17A1 mRNA CTD PMID:33771252 NCBI chr19:46,655,604...46,661,439
Ensembl chr19:46,655,604...46,661,611 		JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 increases expression EXP flufenoxuron results in increased expression of CYP19A1 mRNA CTD PMID:33771252 NCBI chr 9:54,073,221...54,175,448
Ensembl chr 9:54,073,221...54,175,394 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression EXP flufenoxuron results in increased expression of DDIT3 protein CTD PMID:33771252 NCBI chr10:127,126,662...127,132,160
Ensembl chr10:127,126,643...127,132,157
Ensembl chr10:127,126,643...127,132,157 		JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2, subunit 1 alpha increases phosphorylation EXP flufenoxuron results in increased phosphorylation of EIF2S1 protein CTD PMID:33771252 NCBI chr12:78,908,846...78,933,784
Ensembl chr12:78,908,593...78,933,784 		JBrowse link
G Ern1 endoplasmic reticulum to nucleus signalling 1 increases expression EXP flufenoxuron results in increased expression of ERN1 protein CTD PMID:33771252 NCBI chr11:106,285,474...106,378,701
Ensembl chr11:106,285,476...106,378,678 		JBrowse link
G Hsd17b1 hydroxysteroid (17-beta) dehydrogenase 1 decreases expression EXP flufenoxuron results in decreased expression of HSD17B1 mRNA CTD PMID:33771252 NCBI chr11:100,968,792...100,972,014
Ensembl chr11:100,969,237...100,971,353 		JBrowse link
G Hsd17b3 hydroxysteroid (17-beta) dehydrogenase 3 increases expression EXP flufenoxuron results in increased expression of HSD17B3 mRNA CTD PMID:33771252 NCBI chr13:64,206,088...64,237,076
Ensembl chr13:64,206,080...64,237,044 		JBrowse link
G Hspa9 heat shock protein 9 increases expression EXP flufenoxuron results in increased expression of HSPA9 protein CTD PMID:33771252 NCBI chr18:35,070,467...35,087,404
Ensembl chr18:35,070,467...35,087,410 		JBrowse link
G Jun jun proto-oncogene decreases expression EXP flufenoxuron results in decreased expression of JUN mRNA CTD PMID:33771252 NCBI chr 4:94,937,273...94,940,459
Ensembl chr 4:94,937,271...94,940,459 		JBrowse link
G Jund jun D proto-oncogene decreases expression EXP flufenoxuron results in decreased expression of JUND mRNA CTD PMID:33771252 NCBI chr 8:71,150,389...71,153,265
Ensembl chr 8:71,151,599...71,153,265 		JBrowse link
G Mapk1 mitogen-activated protein kinase 1 multiple interactions
increases phosphorylation		 EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [flufenoxuron results in increased phosphorylation of MAPK1 protein]; pyrazolanthrone inhibits the reaction [flufenoxuron results in increased phosphorylation of MAPK1 protein]; U 0126 inhibits the reaction [flufenoxuron results in increased phosphorylation of MAPK1 protein] CTD PMID:33771252 NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317 		JBrowse link
G Mapk3 mitogen-activated protein kinase 3 increases phosphorylation
multiple interactions		 EXP flufenoxuron results in increased phosphorylation of MAPK3 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [flufenoxuron results in increased phosphorylation of MAPK3 protein]; pyrazolanthrone inhibits the reaction [flufenoxuron results in increased phosphorylation of MAPK3 protein]; U 0126 inhibits the reaction [flufenoxuron results in increased phosphorylation of MAPK3 protein]		 CTD PMID:33771252 NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases phosphorylation
multiple interactions		 EXP flufenoxuron results in increased phosphorylation of MAPK8 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [flufenoxuron results in increased phosphorylation of MAPK8 protein]; pyrazolanthrone inhibits the reaction [flufenoxuron results in increased phosphorylation of MAPK8 protein]; U 0126 inhibits the reaction [flufenoxuron results in increased phosphorylation of MAPK8 protein]		 CTD PMID:33771252 NCBI chr14:33,099,855...33,169,213
Ensembl chr14:33,099,855...33,169,115 		JBrowse link
G Pcna proliferating cell nuclear antigen decreases expression EXP flufenoxuron results in decreased expression of PCNA protein CTD PMID:33771252 NCBI chr 2:132,091,206...132,095,100
Ensembl chr 2:132,091,082...132,095,234 		JBrowse link
G Rmdn3 regulator of microtubule dynamics 3 increases expression EXP flufenoxuron results in increased expression of RMDN3 protein CTD PMID:33771252 NCBI chr 2:118,967,479...118,987,515
Ensembl chr 2:118,967,482...118,987,515 		JBrowse link
G Rps6ka1 ribosomal protein S6 kinase polypeptide 1 decreases phosphorylation
multiple interactions		 EXP flufenoxuron results in decreased phosphorylation of RPS6KA1 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [flufenoxuron results in decreased phosphorylation of RPS6KA1 protein]; U 0126 inhibits the reaction [flufenoxuron results in decreased phosphorylation of RPS6KA1 protein]		 CTD PMID:33771252 NCBI chr 4:133,574,601...133,615,466
Ensembl chr 4:133,574,601...133,615,108 		JBrowse link
G Rps6kb1 ribosomal protein S6 kinase, polypeptide 1 decreases phosphorylation
multiple interactions		 EXP flufenoxuron results in decreased phosphorylation of RPS6KB1 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [flufenoxuron results in decreased phosphorylation of RPS6KB1 protein]; pyrazolanthrone affects the reaction [flufenoxuron results in decreased phosphorylation of RPS6KB1 protein]; U 0126 inhibits the reaction [flufenoxuron results in decreased phosphorylation of RPS6KB1 protein]		 CTD PMID:33771252 NCBI chr11:86,389,695...86,435,711
Ensembl chr11:86,389,697...86,435,631 		JBrowse link
G Sqstm1 sequestosome 1 increases phosphorylation EXP flufenoxuron results in increased phosphorylation of SQSTM1 protein CTD PMID:33771252 NCBI chr11:50,090,979...50,105,303
Ensembl chr11:50,090,193...50,101,654 		JBrowse link
G Star steroidogenic acute regulatory protein increases expression EXP flufenoxuron results in increased expression of STAR mRNA CTD PMID:33771252 NCBI chr 8:26,298,502...26,306,010
Ensembl chr 8:26,296,583...26,306,010 		JBrowse link
G Vapb vesicle-associated membrane protein, associated protein B and C increases expression EXP flufenoxuron results in increased expression of VAPB protein CTD PMID:33771252 NCBI chr 2:173,579,378...173,626,132
Ensembl chr 2:173,579,304...173,626,132 		JBrowse link
G Vdac1 voltage-dependent anion channel 1 increases expression EXP flufenoxuron results in increased expression of VDAC1 protein CTD PMID:33771252 NCBI chr11:52,251,905...52,280,224
Ensembl chr11:52,251,687...52,280,224 		JBrowse link
hexaflumuron term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alb albumin decreases expression ISO hexafluoron results in decreased expression of ALB protein CTD PMID:34993831 NCBI chr 5:90,608,729...90,624,461
Ensembl chr 5:90,608,756...90,624,461 		JBrowse link
G Bax BCL2-associated X protein increases expression ISO hexafluoron results in increased expression of BAX mRNA CTD PMID:35773501 NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322 		JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 decreases expression ISO hexafluoron results in decreased expression of BCL2 mRNA CTD PMID:35773501 NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004 		JBrowse link
G Casp3 caspase 3 increases expression ISO hexafluoron results in increased expression of CASP3 mRNA; hexafluoron results in increased expression of CASP3 protein CTD PMID:34993831 PMID:35773501 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724 		JBrowse link
G Cat catalase decreases activity ISO hexafluoron results in decreased activity of CAT protein CTD PMID:35773501 NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505 		JBrowse link
G Cyp2a5 cytochrome P450, family 2, subfamily a, polypeptide 5 increases expression ISO hexafluoron results in increased expression of CYP2A6 mRNA CTD PMID:22310298 NCBI chr 7:26,534,764...26,542,689
Ensembl chr 7:26,534,730...26,542,973 		JBrowse link
G Cyp2b10 cytochrome P450, family 2, subfamily b, polypeptide 10 increases expression
increases activity		 ISO hexafluoron results in increased expression of CYP2B6 mRNA
hexafluoron results in increased activity of CYP2B6 protein		 CTD PMID:22310298 NCBI chr 7:25,597,083...25,626,049
Ensembl chr 7:25,597,045...25,626,049 		JBrowse link
G Gpt glutamic pyruvic transaminase, soluble increases expression ISO hexafluoron results in increased expression of GPT protein CTD PMID:34993831 NCBI chr15:76,580,926...76,583,875
Ensembl chr15:76,579,916...76,583,886 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO hexafluoron results in increased expression of HMOX1 mRNA CTD PMID:34993831 NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217 		JBrowse link
G Keap1 kelch-like ECH-associated protein 1 decreases expression ISO hexafluoron results in decreased expression of KEAP1 mRNA CTD PMID:34993831 NCBI chr 9:21,141,026...21,150,628
Ensembl chr 9:21,141,026...21,150,657 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases expression ISO hexafluoron results in increased expression of MAPK8 mRNA CTD PMID:34993831 PMID:35773501 NCBI chr14:33,099,855...33,169,213
Ensembl chr14:33,099,855...33,169,115 		JBrowse link
G Tnf tumor necrosis factor increases expression ISO hexafluoron results in increased expression of TNF protein CTD PMID:34993831 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
methoprene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rxra retinoid X receptor alpha multiple interactions ISO
EXP		 Methoprene binds to and results in increased activity of RXRA protein CTD PMID:16731579 NCBI chr 2:27,566,457...27,653,331
Ensembl chr 2:27,566,452...27,652,969 		JBrowse link
G Rxrb retinoid X receptor beta multiple interactions ISO Methoprene binds to and results in increased activity of RXRB protein CTD PMID:12970175 NCBI chr17:34,250,786...34,257,377
Ensembl chr17:34,250,786...34,257,373 		JBrowse link
G Ucp1 uncoupling protein 1 (mitochondrial, proton carrier) increases expression EXP Methoprene results in increased expression of UCP1 mRNA CTD PMID:10600643 NCBI chr 8:84,016,977...84,025,085
Ensembl chr 8:84,016,981...84,025,081 		JBrowse link
methoxyfenozide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP-binding cassette, sub-family B member 1A multiple interactions
increases transport		 ISO methoxyfenozide inhibits the reaction [ABCB1 protein results in increased transport of Quinidine]
ABCB1 protein results in increased transport of methoxyfenozide		 CTD PMID:26995013 NCBI chr 5:8,617,091...8,798,575
Ensembl chr 5:8,710,077...8,798,575 		JBrowse link
pyriproxyfen term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 increases expression EXP pyriproxyfen metabolite results in increased expression of CASP3 protein CTD PMID:34289950 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724 		JBrowse link
G Dlx2 distal-less homeobox 2 multiple interactions
increases expression		 EXP [pyriproxyfen metabolite co-treated with Triiodothyronine] results in increased expression of DLX2 mRNA
pyriproxyfen metabolite results in increased expression of DLX2 mRNA		 CTD PMID:34289950 NCBI chr 2:71,373,752...71,377,095
Ensembl chr 2:71,373,752...71,377,098 		JBrowse link
G Fasn fatty acid synthase multiple interactions
increases expression		 EXP [pyriproxyfen metabolite co-treated with Triiodothyronine] results in increased expression of FASN mRNA
pyriproxyfen metabolite results in increased expression of FASN mRNA		 CTD PMID:34289950 NCBI chr11:120,696,784...120,715,992
Ensembl chr11:120,696,672...120,715,373 		JBrowse link
G Msi1 musashi RNA-binding protein 1 increases expression
multiple interactions		 EXP pyriproxyfen metabolite results in increased expression of MSI1 mRNA; pyriproxyfen metabolite results in increased expression of MSI1 protein
[pyriproxyfen metabolite co-treated with Triiodothyronine] results in increased expression of MSI1 mRNA		 CTD PMID:34289950 NCBI chr 5:115,567,734...115,593,757
Ensembl chr 5:115,567,658...115,593,757 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases activity ISO pyriproxyfen results in increased activity of NR1I3 protein CTD PMID:28927721 NCBI chr 1:171,041,503...171,046,414
Ensembl chr 1:171,041,539...171,048,270 		JBrowse link
G Sox10 SRY (sex determining region Y)-box 10 decreases expression
multiple interactions		 EXP pyriproxyfen metabolite results in decreased expression of SOX10 mRNA
[pyriproxyfen metabolite co-treated with Triiodothyronine] results in decreased expression of SOX10 mRNA		 CTD PMID:34289950 NCBI chr15:79,039,113...79,048,690
Ensembl chr15:79,039,108...79,049,440 		JBrowse link
tebufenozide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP-binding cassette, sub-family B member 1A multiple interactions
increases transport		 ISO tebufenozide inhibits the reaction [ABCB1 protein results in increased transport of Quinidine]
ABCB1 protein results in increased transport of tebufenozide		 CTD PMID:26995013 NCBI chr 5:8,617,091...8,798,575
Ensembl chr 5:8,710,077...8,798,575 		JBrowse link
G Cyp2a5 cytochrome P450, family 2, subfamily a, polypeptide 5 increases expression ISO tebufenozide results in increased expression of CYP2A6 mRNA CTD PMID:22310298 NCBI chr 7:26,534,764...26,542,689
Ensembl chr 7:26,534,730...26,542,973 		JBrowse link
G Cyp2b10 cytochrome P450, family 2, subfamily b, polypeptide 10 increases expression ISO tebufenozide results in increased expression of CYP2B6 mRNA CTD PMID:22310298 NCBI chr 7:25,597,083...25,626,049
Ensembl chr 7:25,597,045...25,626,049 		JBrowse link
G Cyp3a11 cytochrome P450, family 3, subfamily a, polypeptide 11 increases expression EXP tebufenozide results in increased expression of CYP3A11 mRNA CTD PMID:22310298 NCBI chr 5:145,791,417...145,816,664
Ensembl chr 5:145,791,236...145,816,774 		JBrowse link
G Rorb RAR-related orphan receptor beta increases activity ISO tebufenozide results in increased activity of RORB protein CTD PMID:20143881 NCBI chr19:18,907,966...19,088,560
Ensembl chr19:18,907,969...19,088,560 		JBrowse link
triflumuron term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cat catalase increases activity ISO triflumuron results in increased activity of CAT protein CTD PMID:32312157 NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases metabolic processing ISO CYP1A1 protein results in increased metabolism of triflumuron CTD PMID:31082524 NCBI chr 9:57,595,211...57,611,107
Ensembl chr 9:57,595,211...57,611,107 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions
increases metabolic processing		 ISO furafylline inhibits the reaction [CYP1A2 protein results in increased metabolism of triflumuron] CTD PMID:31082524 NCBI chr 9:57,584,220...57,590,938
Ensembl chr 9:57,584,220...57,590,986 		JBrowse link
G Cyp2a5 cytochrome P450, family 2, subfamily a, polypeptide 5 increases metabolic processing ISO CYP2A6 protein results in increased metabolism of triflumuron CTD PMID:31082524 NCBI chr 7:26,534,764...26,542,689
Ensembl chr 7:26,534,730...26,542,973 		JBrowse link
G Cyp2b10 cytochrome P450, family 2, subfamily b, polypeptide 10 increases metabolic processing ISO CYP2B6 protein results in increased metabolism of triflumuron CTD PMID:31082524 NCBI chr 7:25,597,083...25,626,049
Ensembl chr 7:25,597,045...25,626,049 		JBrowse link
G Cyp2c29 cytochrome P450, family 2, subfamily c, polypeptide 29 increases metabolic processing ISO CYP2C8 protein results in increased metabolism of triflumuron CTD PMID:31082524 NCBI chr19:39,275,541...39,319,157
Ensembl chr19:39,257,849...39,319,157 		JBrowse link
G Cyp2c38 cytochrome P450, family 2, subfamily c, polypeptide 38 multiple interactions
increases metabolic processing		 ISO Sulfaphenazole inhibits the reaction [CYP2C19 protein results in increased metabolism of triflumuron] CTD PMID:31082524 NCBI chr19:39,379,109...39,451,519
Ensembl chr19:39,378,000...39,451,519 		JBrowse link
G Cyp2c52-ps cytochrome P450, family 2, subfamily c, polypeptide 52, pseudogene increases metabolic processing ISO CYP2C18 protein results in increased metabolism of triflumuron CTD PMID:31082524 NCBI chr19:38,965,106...38,992,071
Ensembl chr19:38,965,091...38,991,733 		JBrowse link
G Cyp2c65 cytochrome P450, family 2, subfamily c, polypeptide 65 increases metabolic processing ISO CYP2C9 protein results in increased metabolism of triflumuron CTD PMID:31082524 NCBI chr19:39,049,450...39,082,392
Ensembl chr19:39,049,459...39,082,388 		JBrowse link
G Cyp2d22 cytochrome P450, family 2, subfamily d, polypeptide 22 increases metabolic processing ISO CYP2D6 protein results in increased metabolism of triflumuron CTD PMID:31082524 NCBI chr15:82,254,728...82,264,461
Ensembl chr15:82,254,728...82,264,461 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 22178
    role 22194
      biological role 22162
        growth regulator 8948
          insect growth regulator 102
            6-deacetylnimbin 0
            asperlactone 0
            benzpyrimoxan 0
            chitin synthesis inhibitor + 66
            ecdysone agonist + 36
            ecdysone antagonists 0
            juvenile hormone antagonists + 0
            juvenile hormone mimic + 15
            salannin + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 22178
    role 22194
      application 21744
        pesticide 18859
          insecticide 17183
            insect growth regulator 102
              6-deacetylnimbin 0
              asperlactone 0
              benzpyrimoxan 0
              chitin synthesis inhibitor + 66
              ecdysone agonist + 36
              ecdysone antagonists 0
              juvenile hormone antagonists + 0
              juvenile hormone mimic + 15
              salannin + 0
paths to the root