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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:inositol
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Accession:CHEBI:24848 term browser browse the term
Definition:Any cyclohexane-1,2,3,4,5,6-hexol.
Synonyms:related_synonym: 1,2,3,4,5,6-cyclohexanehexol;   Formula=C6H12O6;   InChI=1S/C6H12O6/c7-1-2(8)4(10)6(12)5(11)3(1)9/h1-12H;   InChIKey=CDAISMWEOUEBRE-UHFFFAOYSA-N;   SMILES=OC1C(O)C(O)C(O)C(O)C1O;   inositols
 xref_mesh: MESH:D007294



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inositol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cat catalase multiple interactions ISO [Phytic Acid co-treated with Inositol] inhibits the reaction [Streptozocin results in decreased activity of CAT protein] CTD PMID:28757134 NCBI chr 2:103,453,904...103,485,153
Ensembl chr 2:103,453,849...103,485,160
JBrowse link
G Cdipt CDP-diacylglycerol--inositol 3-phosphatidyltransferase (phosphatidylinositol synthase) multiple interactions EXP [Inositol promotes the reaction [CDIPT protein results in increased metabolism of Cytidine Diphosphate Diglycerides]] which results in increased abundance of Cytidine Monophosphate; Inositol promotes the reaction [CDIPT protein results in increased metabolism of Cytidine Diphosphate Diglycerides] CTD PMID:2579070 NCBI chr 7:126,976,458...126,980,499
Ensembl chr 7:126,975,914...126,980,501
JBrowse link
G Chat choline acetyltransferase multiple interactions ISO Inositol inhibits the reaction [Streptozocin affects the localization of CHAT protein] CTD PMID:2431858 NCBI chr14:32,408,203...32,465,909
Ensembl chr14:32,408,203...32,465,989
JBrowse link
G Csf3 colony stimulating factor 3 (granulocyte) multiple interactions ISO [CSF3 protein co-treated with Paclitaxel] results in decreased abundance of Inositol CTD PMID:9018096 NCBI chr11:98,700,183...98,703,631
Ensembl chr11:98,701,263...98,703,629
JBrowse link
G Dek DEK proto-oncogene (DNA binding) multiple interactions ISO DEK protein results in increased chemical synthesis of and results in decreased secretion of Inositol CTD PMID:28558019 NCBI chr13:47,084,767...47,107,530
Ensembl chr13:47,084,775...47,106,201
JBrowse link
G G6pdx glucose-6-phosphate dehydrogenase X-linked multiple interactions ISO [Phytic Acid co-treated with Inositol] inhibits the reaction [Streptozocin results in decreased activity of G6PD protein]; Inositol inhibits the reaction [DDT results in increased activity of G6PD protein] CTD PMID:12667599 PMID:28757134 NCBI chr  X:74,409,483...74,428,880
Ensembl chr  X:74,409,483...74,429,194
JBrowse link
G Hhex hematopoietically expressed homeobox multiple interactions EXP Inositol promotes the reaction [Folic Acid inhibits the reaction [Lithium affects the expression of HHEX mRNA]] CTD PMID:19638421 NCBI chr19:37,434,841...37,440,731
Ensembl chr19:37,434,810...37,440,731
JBrowse link
G Impa1 inositol (myo)-1(or 4)-monophosphatase 1 affects abundance ISO IMPA1 protein affects the abundance of Inositol CTD PMID:11853098 NCBI chr 3:10,311,956...10,331,439
Ensembl chr 3:10,311,956...10,331,439
JBrowse link
G Ins2 insulin II multiple interactions EXP [1-Methyl-3-isobutylxanthine co-treated with butylbenzyl phthalate co-treated with INS protein] results in increased abundance of Inositol analog; [1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] results in increased abundance of Inositol analog CTD PMID:26820058 NCBI chr 7:142,678,656...142,679,726
Ensembl chr 7:142,678,656...142,743,381
JBrowse link
G Isl1 ISL1 transcription factor, LIM/homeodomain multiple interactions EXP Inositol promotes the reaction [Folic Acid inhibits the reaction [Homocysteine affects the expression of ISL1 mRNA]] CTD PMID:19638421 NCBI chr13:116,298,270...116,309,688
Ensembl chr13:116,298,281...116,309,689
JBrowse link
G Miox myo-inositol oxygenase affects binding EXP [MIOX protein binds to Iron] which binds to Inositol CTD PMID:17012379 NCBI chr15:89,334,473...89,337,007
Ensembl chr15:89,334,398...89,337,015
JBrowse link
G Oat ornithine aminotransferase multiple interactions ISO Inositol inhibits the reaction [Cyclic AMP results in increased activity of OAT protein] CTD PMID:2827574 NCBI chr 7:132,557,475...132,576,398
Ensembl chr 7:132,557,478...132,576,398
JBrowse link
G Slc5a3 solute carrier family 5 (inositol transporters), member 3 decreases abundance EXP SLC5A3 gene mutant form results in decreased abundance of Inositol CTD PMID:19754464 NCBI chr16:92,058,322...92,087,473
Ensembl chr16:92,058,322...92,087,473
JBrowse link
1D-myo-inositol 1-phosphate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ppargc1a peroxisome proliferative activated receptor, gamma, coactivator 1 alpha increases expression ISO inositol 1-phosphate results in increased expression of PPARGC1A mRNA CTD PMID:23056435 NCBI chr 5:51,454,249...52,115,853
Ensembl chr 5:51,454,250...51,567,726
JBrowse link
isepamicin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pgd phosphogluconate dehydrogenase decreases activity ISO isepamicin results in decreased activity of PGD protein CTD PMID:15558954 NCBI chr 4:149,149,991...149,166,705
Ensembl chr 4:149,149,991...149,166,771
JBrowse link
G Pkd2 polycystin 2, transient receptor potential cation channel increases expression ISO isepamicin results in increased expression of PKD2 protein mutant form CTD PMID:15001556 NCBI chr 5:104,453,982...104,505,819
Ensembl chr 5:104,459,450...104,505,819
JBrowse link
lipoarabinomannan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Csf2 colony stimulating factor 2 (granulocyte-macrophage) multiple interactions ISO CSF2 protein promotes the reaction [lipoarabinomannan results in increased secretion of CXCL8 protein] CTD PMID:12176910 NCBI chr11:54,247,270...54,249,899
Ensembl chr11:54,247,271...54,249,667
JBrowse link
G Cxcl15 chemokine (C-X-C motif) ligand 15 multiple interactions
increases secretion
ISO CSF2 protein promotes the reaction [lipoarabinomannan results in increased secretion of CXCL8 protein] CTD PMID:12176910 NCBI chr 5:90,794,534...90,803,067
Ensembl chr 5:90,794,534...90,803,067
JBrowse link
G Cxcr2 chemokine (C-X-C motif) receptor 2 decreases expression ISO lipoarabinomannan results in decreased expression of CXCR2 protein CTD PMID:10950785 NCBI chr 1:74,153,994...74,161,246
Ensembl chr 1:74,153,989...74,161,246
JBrowse link
G Il12b interleukin 12b multiple interactions EXP lipoarabinomannan inhibits the reaction [Lipopolysaccharides results in increased expression of IL12B protein] CTD PMID:16263713 NCBI chr11:44,400,063...44,414,677
Ensembl chr11:44,400,063...44,414,033
JBrowse link
G Irak1 interleukin-1 receptor-associated kinase 1 multiple interactions EXP lipoarabinomannan inhibits the reaction [IRAK1 protein binds to TRAF6 protein] CTD PMID:16263713 NCBI chr  X:74,013,914...74,023,921
Ensembl chr  X:74,013,914...74,023,918
JBrowse link
G Irak3 interleukin-1 receptor-associated kinase 3 increases expression
increases expression
EXP lipoarabinomannan results in increased expression of IRAK3 protein
Lipoarabinomannan increases expression of Irak3 mRNA and protein in macrophages
CTD
RGD
PMID:16263713 PMID:16263713 RGD:36049804 NCBI chr10:120,141,648...120,202,130
Ensembl chr10:120,141,648...120,202,130
JBrowse link
G Mmp9 matrix metallopeptidase 9 increases activity EXP lipoarabinomannan results in increased activity of MMP9 protein CTD PMID:11839551 NCBI chr 2:164,940,326...164,955,850
Ensembl chr 2:164,940,780...164,955,850
JBrowse link
G Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 multiple interactions EXP lipoarabinomannan results in decreased localization of and results in decreased activity of NFKB1 protein CTD PMID:16263713 NCBI chr 3:135,584,655...135,691,969
Ensembl chr 3:135,584,655...135,691,547
JBrowse link
G Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha decreases phosphorylation EXP lipoarabinomannan results in decreased phosphorylation of NFKBIA protein CTD PMID:16263713 NCBI chr12:55,489,409...55,492,647
Ensembl chr12:55,489,410...55,492,647
JBrowse link
G Rel reticuloendotheliosis oncogene multiple interactions EXP lipoarabinomannan results in decreased localization of and results in decreased activity of REL protein CTD PMID:16263713 NCBI chr11:23,736,847...23,770,969
Ensembl chr11:23,736,847...23,770,970
JBrowse link
G Traf6 TNF receptor-associated factor 6 multiple interactions EXP lipoarabinomannan inhibits the reaction [IRAK1 protein binds to TRAF6 protein] CTD PMID:16263713 NCBI chr 2:101,678,420...101,701,668
Ensembl chr 2:101,678,429...101,701,669
JBrowse link
lipophosphoglycan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd14 CD14 antigen multiple interactions ISO CD14 protein promotes the reaction [lipopeptidophosphoglycan results in increased activity of TLR2 protein]; CD14 protein promotes the reaction [lipopeptidophosphoglycan results in increased activity of TLR4 protein] CTD PMID:15910421 NCBI chr18:36,725,064...36,726,815
Ensembl chr18:36,725,067...36,726,798
JBrowse link
G Cxcl15 chemokine (C-X-C motif) ligand 15 multiple interactions ISO [lipopeptidophosphoglycan binds to and results in increased activity of TLR2 protein] which results in increased secretion of CXCL8 protein; [lipopeptidophosphoglycan binds to and results in increased activity of TLR4 protein] which results in increased secretion of CXCL8 protein CTD PMID:15910421 NCBI chr 5:90,794,534...90,803,067
Ensembl chr 5:90,794,534...90,803,067
JBrowse link
G Il10 interleukin 10 multiple interactions ISO [lipopeptidophosphoglycan binds to and results in increased activity of TLR2 protein] which results in increased secretion of IL10 protein; [lipopeptidophosphoglycan binds to and results in increased activity of TLR4 protein] which results in increased secretion of IL10 protein CTD PMID:15910421 NCBI chr 1:131,019,845...131,024,970
Ensembl chr 1:131,019,845...131,024,974
JBrowse link
G Il12b interleukin 12b multiple interactions ISO [lipopeptidophosphoglycan binds to and results in increased activity of TLR2 protein] which results in increased secretion of IL12B protein; [lipopeptidophosphoglycan binds to and results in increased activity of TLR4 protein] which results in increased secretion of IL12B protein CTD PMID:15910421 NCBI chr11:44,400,063...44,414,677
Ensembl chr11:44,400,063...44,414,033
JBrowse link
G Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 multiple interactions ISO [lipopeptidophosphoglycan binds to and results in increased activity of TLR2 protein] results in increased activity of [NFKB1 protein binds to RELA protein]; [lipopeptidophosphoglycan binds to and results in increased activity of TLR4 protein] results in increased activity of [NFKB1 protein binds to RELA protein] CTD PMID:15910421 NCBI chr 3:135,584,655...135,691,969
Ensembl chr 3:135,584,655...135,691,547
JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) multiple interactions ISO [lipopeptidophosphoglycan binds to and results in increased activity of TLR2 protein] results in increased activity of [NFKB1 protein binds to RELA protein]; [lipopeptidophosphoglycan binds to and results in increased activity of TLR4 protein] results in increased activity of [NFKB1 protein binds to RELA protein] CTD PMID:15910421 NCBI chr19:5,637,442...5,648,134
Ensembl chr19:5,637,483...5,648,130
JBrowse link
G Tlr2 toll-like receptor 2 multiple interactions
increases response to substance
ISO
EXP
[lipopeptidophosphoglycan binds to and results in increased activity of TLR2 protein] results in increased activity of [NFKB1 protein binds to RELA protein]; [lipopeptidophosphoglycan binds to and results in increased activity of TLR2 protein] which results in increased secretion of CXCL8 protein; [lipopeptidophosphoglycan binds to and results in increased activity of TLR2 protein] which results in increased secretion of IL10 protein; [lipopeptidophosphoglycan binds to and results in increased activity of TLR2 protein] which results in increased secretion of IL12B protein; [lipopeptidophosphoglycan binds to and results in increased activity of TLR2 protein] which results in increased secretion of TNF protein; CD14 protein promotes the reaction [lipopeptidophosphoglycan results in increased activity of TLR2 protein]; lipopeptidophosphoglycan binds to and results in increased activity of TLR2 protein
TLR2 protein results in increased susceptibility to lipopeptidophosphoglycan
CTD PMID:15910421 NCBI chr 3:83,836,272...83,841,824
Ensembl chr 3:83,836,272...83,841,767
JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions
increases response to substance
ISO
EXP
[lipopeptidophosphoglycan binds to and results in increased activity of TLR4 protein] results in increased activity of [NFKB1 protein binds to RELA protein]; [lipopeptidophosphoglycan binds to and results in increased activity of TLR4 protein] which results in increased secretion of CXCL8 protein; [lipopeptidophosphoglycan binds to and results in increased activity of TLR4 protein] which results in increased secretion of IL10 protein; [lipopeptidophosphoglycan binds to and results in increased activity of TLR4 protein] which results in increased secretion of IL12B protein; [lipopeptidophosphoglycan binds to and results in increased activity of TLR4 protein] which results in increased secretion of TNF protein; CD14 protein promotes the reaction [lipopeptidophosphoglycan results in increased activity of TLR4 protein]; lipopeptidophosphoglycan binds to and results in increased activity of TLR4 protein
TLR4 protein results in increased susceptibility to lipopeptidophosphoglycan
CTD PMID:15910421 NCBI chr 4:66,827,551...66,846,581
Ensembl chr 4:66,827,584...66,930,284
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO [lipopeptidophosphoglycan binds to and results in increased activity of TLR2 protein] which results in increased secretion of TNF protein; [lipopeptidophosphoglycan binds to and results in increased activity of TLR4 protein] which results in increased secretion of TNF protein CTD PMID:15910421 NCBI chr17:35,199,367...35,202,007
Ensembl chr17:35,199,381...35,202,007
JBrowse link
netilmycin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pgd phosphogluconate dehydrogenase decreases activity ISO Netilmicin results in decreased activity of PGD protein CTD PMID:15558954 NCBI chr 4:149,149,991...149,166,705
Ensembl chr 4:149,149,991...149,166,771
JBrowse link
paromomycin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atm ataxia telangiectasia mutated increases expression ISO Paromomycin results in increased expression of ATM protein mutant form CTD PMID:15498871 NCBI chr 9:53,437,122...53,536,828
Ensembl chr 9:53,439,149...53,536,740
JBrowse link
G mt-Rnr1 12S rRNA, mitochondrial affects response to substance ISO RNR1 gene mutant form affects the susceptibility to Paromomycin CTD PMID:15722487 NCBI chr MT:70...1,024
Ensembl chr MT:70...1,024
JBrowse link
phosphatidylinositol 4-phosphate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G F2 coagulation factor II multiple interactions
increases abundance
ISO resveratrol inhibits the reaction [F2 protein results in increased abundance of phosphatidylinositol 4-phosphate] CTD PMID:16051184 NCBI chr 2:91,612,397...91,636,457
Ensembl chr 2:91,625,320...91,636,414
JBrowse link
G Ncs1 neuronal calcium sensor 1 increases phosphorylation
multiple interactions
ISO NCS1 protein results in increased phosphorylation of phosphatidylinositol 4-phosphate
wortmannin inhibits the reaction [NCS1 protein results in increased phosphorylation of phosphatidylinositol 4-phosphate]
CTD PMID:12471042 NCBI chr 2:31,245,708...31,295,989
Ensembl chr 2:31,245,823...31,295,989
JBrowse link
phosphatidylinositol dimannoside term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il6 interleukin 6 multiple interactions EXP [phosphatidylinositol dimannoside analog co-treated with Thioglycolates] results in increased expression of IL6 protein; phosphatidylinositol dimannoside analog inhibits the reaction [[Lipopolysaccharides co-treated with Thioglycolates] results in increased expression of IL6 protein]; phosphatidylinositol dimannoside analog promotes the reaction [[Lipopolysaccharides co-treated with Thioglycolates] results in increased expression of IL6 protein]; TLR4 gene mutant form inhibits the reaction [[phosphatidylinositol dimannoside analog co-treated with Thioglycolates] results in increased expression of IL6 protein] CTD PMID:21936536 NCBI chr 5:30,013,114...30,019,975
Ensembl chr 5:30,013,114...30,019,981
JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions EXP TLR4 gene mutant form inhibits the reaction [[phosphatidylinositol dimannoside analog co-treated with Thioglycolates] results in increased expression of IL6 protein] CTD PMID:21936536 NCBI chr 4:66,827,551...66,846,581
Ensembl chr 4:66,827,584...66,930,284
JBrowse link
pinitol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cat catalase multiple interactions ISO
EXP
pinitol inhibits the reaction [Streptozocin results in decreased activity of CAT protein]
pinitol inhibits the reaction [Cisplatin results in decreased activity of CAT protein]
CTD PMID:20643114 PMID:29752894 NCBI chr 2:103,453,904...103,485,153
Ensembl chr 2:103,453,849...103,485,160
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO
EXP
pinitol inhibits the reaction [Streptozocin results in increased expression of IL1B protein]
pinitol inhibits the reaction [Cisplatin results in increased expression of IL1B protein]
CTD PMID:20643114 PMID:29752894 NCBI chr 2:129,364,569...129,371,164
Ensembl chr 2:129,364,570...129,371,139
JBrowse link
G Il6 interleukin 6 multiple interactions ISO
EXP
pinitol inhibits the reaction [Streptozocin results in increased expression of IL6 protein]
pinitol inhibits the reaction [Cisplatin results in increased expression of IL6 protein]
CTD PMID:20643114 PMID:29752894 NCBI chr 5:30,013,114...30,019,975
Ensembl chr 5:30,013,114...30,019,981
JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) multiple interactions ISO pinitol inhibits the reaction [Streptozocin results in increased expression of RELA protein] CTD PMID:20643114 NCBI chr19:5,637,442...5,648,134
Ensembl chr19:5,637,483...5,648,130
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP
pinitol inhibits the reaction [Streptozocin results in increased expression of TNF protein]
pinitol inhibits the reaction [Cisplatin results in increased expression of TNF protein]
CTD PMID:20643114 PMID:29752894 NCBI chr17:35,199,367...35,202,007
Ensembl chr17:35,199,381...35,202,007
JBrowse link
streptomycin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hoxb9 homeobox B9 multiple interactions ISO [Penicillins co-treated with Streptomycin] results in increased expression of HOXB9 mRNA CTD PMID:31711903 NCBI chr11:96,271,330...96,276,595
Ensembl chr11:96,271,457...96,276,595
JBrowse link
G mt-Rnr1 12S rRNA, mitochondrial increases response to substance ISO RNR1 gene mutant form results in increased susceptibility to Streptomycin; RNR1 gene SNP results in increased susceptibility to Streptomycin; RNR1 protein mutant form results in increased susceptibility to Streptomycin CTD PMID:9391883 PMID:12031626 PMID:12037390 PMID:15141753 NCBI chr MT:70...1,024
Ensembl chr MT:70...1,024
JBrowse link
G Pax3 paired box 3 multiple interactions ISO [Penicillins co-treated with Streptomycin] results in increased expression of PAX3 mRNA CTD PMID:31711903 NCBI chr 1:78,101,267...78,197,136
Ensembl chr 1:78,101,267...78,197,134
JBrowse link
G Tcf15 transcription factor 15 multiple interactions ISO [Penicillins co-treated with Streptomycin] results in increased expression of TCF15 mRNA CTD PMID:31711903 NCBI chr 2:152,143,056...152,149,097
Ensembl chr 2:152,143,561...152,149,097
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Streptomycin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein] CTD PMID:17699551 NCBI chr17:35,199,367...35,202,007
Ensembl chr17:35,199,381...35,202,007
JBrowse link
G Uncx UNC homeobox multiple interactions ISO [Penicillins co-treated with Streptomycin] results in increased expression of UNCX mRNA CTD PMID:31711903 NCBI chr 5:139,543,865...139,548,179
Ensembl chr 5:139,543,494...139,548,179
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 21787
    chemical entity 21785
      molecular entity 21772
        polyatomic entity 21666
          heteroatomic molecular entity 21591
            hydroxides 20256
              organic hydroxy compound 19191
                polyol 8173
                  cyclitol 2446
                    inositol 43
                      allo-inositol 0
                      chiro-inositol + 5
                      cis-inositol 0
                      epi-inositol 0
                      glycerophosphoinositol + 20
                      muco-inositol 0
                      myo-inositol + 1
                      neo-inositol 0
                      scyllo-inositol + 9
Path 2
Term Annotations click to browse term
  CHEBI ontology 21787
    subatomic particle 21773
      composite particle 21773
        hadron 21773
          baryon 21773
            nucleon 21773
              atomic nucleus 21773
                atom 21773
                  main group element atom 21690
                    p-block element atom 21690
                      chalcogen 20858
                        oxygen atom 20836
                          oxygen molecular entity 20836
                            hydroxides 20256
                              organic hydroxy compound 19191
                                polyol 8173
                                  cyclitol 2446
                                    inositol 43
                                      allo-inositol 0
                                      chiro-inositol + 5
                                      cis-inositol 0
                                      epi-inositol 0
                                      glycerophosphoinositol + 20
                                      muco-inositol 0
                                      myo-inositol + 1
                                      neo-inositol 0
                                      scyllo-inositol + 9
paths to the root