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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:inositol
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Accession:CHEBI:24848 term browser browse the term
Definition:Any cyclohexane-1,2,3,4,5,6-hexol.
Synonyms:related_synonym: 1,2,3,4,5,6-cyclohexanehexol;   Formula=C6H12O6;   InChI=1S/C6H12O6/c7-1-2(8)4(10)6(12)5(11)3(1)9/h1-12H;   InChIKey=CDAISMWEOUEBRE-UHFFFAOYSA-N;   SMILES=OC1C(O)C(O)C(O)C(O)C1O;   inositols
 xref_mesh: MESH:D007294



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inositol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CAT catalase multiple interactions ISO [Phytic Acid co-treated with Inositol] inhibits the reaction [Streptozocin results in decreased activity of CAT protein] CTD PMID:28757134 NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060
JBrowse link
G CDIPT CDP-diacylglycerol--inositol 3-phosphatidyltransferase multiple interactions ISO [Inositol promotes the reaction [CDIPT protein results in increased metabolism of Cytidine Diphosphate Diglycerides]] which results in increased abundance of Cytidine Monophosphate; Inositol promotes the reaction [CDIPT protein results in increased metabolism of Cytidine Diphosphate Diglycerides] CTD PMID:2579070 NCBI chr16:29,858,357...29,863,226
Ensembl chr16:29,858,357...29,863,414
JBrowse link
G CHAT choline O-acetyltransferase multiple interactions ISO Inositol inhibits the reaction [Streptozocin affects the localization of CHAT protein] CTD PMID:2431858 NCBI chr10:49,609,095...49,667,942
Ensembl chr10:49,609,095...49,667,942
JBrowse link
G CSF3 colony stimulating factor 3 multiple interactions EXP [CSF3 protein co-treated with Paclitaxel] results in decreased abundance of Inositol CTD PMID:9018096 NCBI chr17:40,015,440...40,017,813
Ensembl chr17:40,015,361...40,017,813
JBrowse link
G DEK DEK proto-oncogene multiple interactions EXP DEK protein results in increased chemical synthesis of and results in decreased secretion of Inositol CTD PMID:28558019 NCBI chr 6:18,223,860...18,264,541
Ensembl chr 6:18,223,860...18,264,548
JBrowse link
G G6PD glucose-6-phosphate dehydrogenase multiple interactions ISO [Phytic Acid co-treated with Inositol] inhibits the reaction [Streptozocin results in decreased activity of G6PD protein]; Inositol inhibits the reaction [DDT results in increased activity of G6PD protein] CTD PMID:12667599 PMID:28757134 NCBI chr  X:154,531,390...154,547,569
Ensembl chr  X:154,531,391...154,547,572
JBrowse link
G HHEX hematopoietically expressed homeobox multiple interactions ISO Inositol promotes the reaction [Folic Acid inhibits the reaction [Lithium affects the expression of HHEX mRNA]] CTD PMID:19638421 NCBI chr10:92,689,955...92,695,647
Ensembl chr10:92,689,955...92,695,647
JBrowse link
G IMPA1 inositol monophosphatase 1 affects abundance ISO IMPA1 protein affects the abundance of Inositol CTD PMID:11853098 NCBI chr 8:81,656,914...81,686,325
Ensembl chr 8:81,656,914...81,686,331
JBrowse link
G INS insulin multiple interactions ISO [1-Methyl-3-isobutylxanthine co-treated with butylbenzyl phthalate co-treated with INS protein] results in increased abundance of Inositol analog; [1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] results in increased abundance of Inositol analog CTD PMID:26820058 NCBI chr11:2,159,779...2,161,209
Ensembl chr11:2,159,779...2,161,221
JBrowse link
G ISL1 ISL LIM homeobox 1 multiple interactions ISO Inositol promotes the reaction [Folic Acid inhibits the reaction [Homocysteine affects the expression of ISL1 mRNA]] CTD PMID:19638421 NCBI chr 5:51,383,448...51,394,730
Ensembl chr 5:51,383,448...51,394,730
JBrowse link
G MIOX myo-inositol oxygenase affects binding ISO [MIOX protein binds to Iron] which binds to Inositol CTD PMID:17012379 NCBI chr22:50,483,988...50,490,648
Ensembl chr22:50,486,784...50,490,648
JBrowse link
G OAT ornithine aminotransferase multiple interactions ISO Inositol inhibits the reaction [Cyclic AMP results in increased activity of OAT protein] CTD PMID:2827574 NCBI chr10:124,397,303...124,418,923
Ensembl chr10:124,397,303...124,418,976
JBrowse link
G SLC5A3 solute carrier family 5 member 3 decreases abundance ISO SLC5A3 gene mutant form results in decreased abundance of Inositol CTD PMID:19754464 NCBI chr21:34,073,578...34,106,260
Ensembl chr21:34,073,578...34,106,260
JBrowse link
1D-myo-inositol 1-phosphate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PPARGC1A PPARG coactivator 1 alpha increases expression EXP inositol 1-phosphate results in increased expression of PPARGC1A mRNA CTD PMID:23056435 NCBI chr 4:23,792,021...24,472,905
Ensembl chr 4:23,755,041...23,904,089
JBrowse link
isepamicin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PGD phosphogluconate dehydrogenase decreases activity ISO isepamicin results in decreased activity of PGD protein CTD PMID:15558954 NCBI chr 1:10,399,064...10,420,511
Ensembl chr 1:10,398,592...10,420,511
JBrowse link
G PKD2 polycystin 2, transient receptor potential cation channel increases expression EXP isepamicin results in increased expression of PKD2 protein mutant form CTD PMID:15001556 NCBI chr 4:88,007,635...88,077,779
Ensembl chr 4:88,007,635...88,077,777
JBrowse link
lipoarabinomannan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CSF2 colony stimulating factor 2 multiple interactions EXP CSF2 protein promotes the reaction [lipoarabinomannan results in increased secretion of CXCL8 protein] CTD PMID:12176910 NCBI chr 5:132,073,789...132,076,170
Ensembl chr 5:132,073,789...132,076,170
JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 multiple interactions
increases secretion
EXP CSF2 protein promotes the reaction [lipoarabinomannan results in increased secretion of CXCL8 protein] CTD PMID:12176910 NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,541...73,743,716
JBrowse link
G CXCR2 C-X-C motif chemokine receptor 2 decreases expression EXP lipoarabinomannan results in decreased expression of CXCR2 protein CTD PMID:10950785 NCBI chr 2:218,125,294...218,137,253
Ensembl chr 2:218,125,289...218,137,251
JBrowse link
G IL12B interleukin 12B multiple interactions ISO lipoarabinomannan inhibits the reaction [Lipopolysaccharides results in increased expression of IL12B protein] CTD PMID:16263713 NCBI chr 5:159,314,780...159,330,487
Ensembl chr 5:159,314,780...159,330,487
JBrowse link
G IRAK1 interleukin 1 receptor associated kinase 1 multiple interactions ISO lipoarabinomannan inhibits the reaction [IRAK1 protein binds to TRAF6 protein] CTD PMID:16263713 NCBI chr  X:154,010,507...154,019,984
Ensembl chr  X:154,010,506...154,019,902
JBrowse link
G IRAK3 interleukin 1 receptor associated kinase 3 increases expression
increases expression
ISO lipoarabinomannan results in increased expression of IRAK3 protein
Lipoarabinomannan increases expression of Irak3 mRNA and protein in macrophages
CTD
RGD
PMID:16263713 PMID:16263713 RGD:36049804 NCBI chr12:66,189,214...66,254,622
Ensembl chr12:66,189,195...66,254,622
JBrowse link
G MMP9 matrix metallopeptidase 9 increases activity ISO lipoarabinomannan results in increased activity of MMP9 protein CTD PMID:11839551 NCBI chr20:46,008,908...46,016,561
Ensembl chr20:46,008,908...46,016,561
JBrowse link
G NFKB1 nuclear factor kappa B subunit 1 multiple interactions ISO lipoarabinomannan results in decreased localization of and results in decreased activity of NFKB1 protein CTD PMID:16263713 NCBI chr 4:102,501,266...102,617,302
Ensembl chr 4:102,501,331...102,617,302
JBrowse link
G NFKBIA NFKB inhibitor alpha decreases phosphorylation ISO lipoarabinomannan results in decreased phosphorylation of NFKBIA protein CTD PMID:16263713 NCBI chr14:35,401,513...35,404,749
Ensembl chr14:35,401,513...35,404,749
JBrowse link
G REL REL proto-oncogene, NF-kB subunit multiple interactions ISO lipoarabinomannan results in decreased localization of and results in decreased activity of REL protein CTD PMID:16263713 NCBI chr 2:60,881,521...60,931,612
Ensembl chr 2:60,881,521...60,931,612
JBrowse link
G TRAF6 TNF receptor associated factor 6 multiple interactions ISO lipoarabinomannan inhibits the reaction [IRAK1 protein binds to TRAF6 protein] CTD PMID:16263713 NCBI chr11:36,483,769...36,510,313
Ensembl chr11:36,483,769...36,510,272
JBrowse link
lipophosphoglycan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CD14 CD14 molecule multiple interactions EXP CD14 protein promotes the reaction [lipopeptidophosphoglycan results in increased activity of TLR2 protein]; CD14 protein promotes the reaction [lipopeptidophosphoglycan results in increased activity of TLR4 protein] CTD PMID:15910421 NCBI chr 5:140,631,732...140,633,701
Ensembl chr 5:140,631,728...140,633,701
JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 multiple interactions EXP [lipopeptidophosphoglycan binds to and results in increased activity of TLR2 protein] which results in increased secretion of CXCL8 protein; [lipopeptidophosphoglycan binds to and results in increased activity of TLR4 protein] which results in increased secretion of CXCL8 protein CTD PMID:15910421 NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,541...73,743,716
JBrowse link
G IL10 interleukin 10 multiple interactions EXP [lipopeptidophosphoglycan binds to and results in increased activity of TLR2 protein] which results in increased secretion of IL10 protein; [lipopeptidophosphoglycan binds to and results in increased activity of TLR4 protein] which results in increased secretion of IL10 protein CTD PMID:15910421 NCBI chr 1:206,767,602...206,772,494
Ensembl chr 1:206,767,602...206,774,541
JBrowse link
G IL12B interleukin 12B multiple interactions EXP [lipopeptidophosphoglycan binds to and results in increased activity of TLR2 protein] which results in increased secretion of IL12B protein; [lipopeptidophosphoglycan binds to and results in increased activity of TLR4 protein] which results in increased secretion of IL12B protein CTD PMID:15910421 NCBI chr 5:159,314,780...159,330,487
Ensembl chr 5:159,314,780...159,330,487
JBrowse link
G NFKB1 nuclear factor kappa B subunit 1 multiple interactions EXP [lipopeptidophosphoglycan binds to and results in increased activity of TLR2 protein] results in increased activity of [NFKB1 protein binds to RELA protein]; [lipopeptidophosphoglycan binds to and results in increased activity of TLR4 protein] results in increased activity of [NFKB1 protein binds to RELA protein] CTD PMID:15910421 NCBI chr 4:102,501,266...102,617,302
Ensembl chr 4:102,501,331...102,617,302
JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit multiple interactions EXP [lipopeptidophosphoglycan binds to and results in increased activity of TLR2 protein] results in increased activity of [NFKB1 protein binds to RELA protein]; [lipopeptidophosphoglycan binds to and results in increased activity of TLR4 protein] results in increased activity of [NFKB1 protein binds to RELA protein] CTD PMID:15910421 NCBI chr11:65,653,601...65,662,946
Ensembl chr11:65,653,597...65,663,090
JBrowse link
G TLR2 toll like receptor 2 multiple interactions
increases response to substance
EXP
ISO
[lipopeptidophosphoglycan binds to and results in increased activity of TLR2 protein] results in increased activity of [NFKB1 protein binds to RELA protein]; [lipopeptidophosphoglycan binds to and results in increased activity of TLR2 protein] which results in increased secretion of CXCL8 protein; [lipopeptidophosphoglycan binds to and results in increased activity of TLR2 protein] which results in increased secretion of IL10 protein; [lipopeptidophosphoglycan binds to and results in increased activity of TLR2 protein] which results in increased secretion of IL12B protein; [lipopeptidophosphoglycan binds to and results in increased activity of TLR2 protein] which results in increased secretion of TNF protein; CD14 protein promotes the reaction [lipopeptidophosphoglycan results in increased activity of TLR2 protein]; lipopeptidophosphoglycan binds to and results in increased activity of TLR2 protein
TLR2 protein results in increased susceptibility to lipopeptidophosphoglycan
CTD PMID:15910421 NCBI chr 4:153,684,080...153,710,643
Ensembl chr 4:153,684,070...153,706,260
JBrowse link
G TLR4 toll like receptor 4 multiple interactions
increases response to substance
EXP
ISO
[lipopeptidophosphoglycan binds to and results in increased activity of TLR4 protein] results in increased activity of [NFKB1 protein binds to RELA protein]; [lipopeptidophosphoglycan binds to and results in increased activity of TLR4 protein] which results in increased secretion of CXCL8 protein; [lipopeptidophosphoglycan binds to and results in increased activity of TLR4 protein] which results in increased secretion of IL10 protein; [lipopeptidophosphoglycan binds to and results in increased activity of TLR4 protein] which results in increased secretion of IL12B protein; [lipopeptidophosphoglycan binds to and results in increased activity of TLR4 protein] which results in increased secretion of TNF protein; CD14 protein promotes the reaction [lipopeptidophosphoglycan results in increased activity of TLR4 protein]; lipopeptidophosphoglycan binds to and results in increased activity of TLR4 protein
TLR4 protein results in increased susceptibility to lipopeptidophosphoglycan
CTD PMID:15910421 NCBI chr 9:117,704,403...117,724,735
Ensembl chr 9:117,704,175...117,724,735
JBrowse link
G TNF tumor necrosis factor multiple interactions EXP [lipopeptidophosphoglycan binds to and results in increased activity of TLR2 protein] which results in increased secretion of TNF protein; [lipopeptidophosphoglycan binds to and results in increased activity of TLR4 protein] which results in increased secretion of TNF protein CTD PMID:15910421 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
JBrowse link
netilmycin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PGD phosphogluconate dehydrogenase decreases activity ISO Netilmicin results in decreased activity of PGD protein CTD PMID:15558954 NCBI chr 1:10,399,064...10,420,511
Ensembl chr 1:10,398,592...10,420,511
JBrowse link
paromomycin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATM ATM serine/threonine kinase increases expression EXP Paromomycin results in increased expression of ATM protein mutant form CTD PMID:15498871 NCBI chr11:108,222,484...108,369,102
Ensembl chr11:108,223,044...108,369,102
JBrowse link
G MT-RNR1 mitochondrially encoded 12S rRNA affects response to substance EXP RNR1 gene mutant form affects the susceptibility to Paromomycin CTD PMID:15722487 NCBI chr MT:648...1,601
Ensembl chr MT:648...1,601
JBrowse link
phosphatidylinositol 4-phosphate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G F2 coagulation factor II, thrombin multiple interactions
increases abundance
EXP resveratrol inhibits the reaction [F2 protein results in increased abundance of phosphatidylinositol 4-phosphate] CTD PMID:16051184 NCBI chr11:46,719,213...46,739,506
Ensembl chr11:46,719,196...46,739,506
JBrowse link
G NCS1 neuronal calcium sensor 1 increases phosphorylation
multiple interactions
ISO NCS1 protein results in increased phosphorylation of phosphatidylinositol 4-phosphate
wortmannin inhibits the reaction [NCS1 protein results in increased phosphorylation of phosphatidylinositol 4-phosphate]
CTD PMID:12471042 NCBI chr 9:130,172,404...130,237,303
Ensembl chr 9:130,172,404...130,237,303
JBrowse link
phosphatidylinositol dimannoside term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G IL6 interleukin 6 multiple interactions ISO [phosphatidylinositol dimannoside analog co-treated with Thioglycolates] results in increased expression of IL6 protein; phosphatidylinositol dimannoside analog inhibits the reaction [[Lipopolysaccharides co-treated with Thioglycolates] results in increased expression of IL6 protein]; phosphatidylinositol dimannoside analog promotes the reaction [[Lipopolysaccharides co-treated with Thioglycolates] results in increased expression of IL6 protein]; TLR4 gene mutant form inhibits the reaction [[phosphatidylinositol dimannoside analog co-treated with Thioglycolates] results in increased expression of IL6 protein] CTD PMID:21936536 NCBI chr 7:22,725,889...22,732,002
Ensembl chr 7:22,725,884...22,732,002
JBrowse link
G TLR4 toll like receptor 4 multiple interactions ISO TLR4 gene mutant form inhibits the reaction [[phosphatidylinositol dimannoside analog co-treated with Thioglycolates] results in increased expression of IL6 protein] CTD PMID:21936536 NCBI chr 9:117,704,403...117,724,735
Ensembl chr 9:117,704,175...117,724,735
JBrowse link
pinitol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CAT catalase multiple interactions ISO pinitol inhibits the reaction [Streptozocin results in decreased activity of CAT protein]
pinitol inhibits the reaction [Cisplatin results in decreased activity of CAT protein]
CTD PMID:20643114 PMID:29752894 NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060
JBrowse link
G IL1B interleukin 1 beta multiple interactions ISO pinitol inhibits the reaction [Streptozocin results in increased expression of IL1B protein]
pinitol inhibits the reaction [Cisplatin results in increased expression of IL1B protein]
CTD PMID:20643114 PMID:29752894 NCBI chr 2:112,829,751...112,836,843
Ensembl chr 2:112,829,751...112,836,816
JBrowse link
G IL6 interleukin 6 multiple interactions ISO pinitol inhibits the reaction [Streptozocin results in increased expression of IL6 protein]
pinitol inhibits the reaction [Cisplatin results in increased expression of IL6 protein]
CTD PMID:20643114 PMID:29752894 NCBI chr 7:22,725,889...22,732,002
Ensembl chr 7:22,725,884...22,732,002
JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit multiple interactions ISO pinitol inhibits the reaction [Streptozocin results in increased expression of RELA protein] CTD PMID:20643114 NCBI chr11:65,653,601...65,662,946
Ensembl chr11:65,653,597...65,663,090
JBrowse link
G TNF tumor necrosis factor multiple interactions ISO pinitol inhibits the reaction [Streptozocin results in increased expression of TNF protein]
pinitol inhibits the reaction [Cisplatin results in increased expression of TNF protein]
CTD PMID:20643114 PMID:29752894 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
JBrowse link
streptomycin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HOXB9 homeobox B9 multiple interactions EXP [Penicillins co-treated with Streptomycin] results in increased expression of HOXB9 mRNA CTD PMID:31711903 NCBI chr17:48,621,156...48,626,358
Ensembl chr17:48,621,156...48,626,358
JBrowse link
G MT-RNR1 mitochondrially encoded 12S rRNA increases response to substance EXP RNR1 gene mutant form results in increased susceptibility to Streptomycin; RNR1 gene SNP results in increased susceptibility to Streptomycin; RNR1 protein mutant form results in increased susceptibility to Streptomycin CTD PMID:9391883 PMID:12031626 PMID:12037390 PMID:15141753 NCBI chr MT:648...1,601
Ensembl chr MT:648...1,601
JBrowse link
G PAX3 paired box 3 multiple interactions EXP [Penicillins co-treated with Streptomycin] results in increased expression of PAX3 mRNA CTD PMID:31711903 NCBI chr 2:222,199,887...222,298,998
Ensembl chr 2:222,199,887...222,298,998
JBrowse link
G TCF15 transcription factor 15 multiple interactions EXP [Penicillins co-treated with Streptomycin] results in increased expression of TCF15 mRNA CTD PMID:31711903 NCBI chr20:604,257...610,309
Ensembl chr20:604,257...610,309
JBrowse link
G TNF tumor necrosis factor multiple interactions EXP Streptomycin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein] CTD PMID:17699551 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
JBrowse link
G UNCX UNC homeobox multiple interactions EXP [Penicillins co-treated with Streptomycin] results in increased expression of UNCX mRNA CTD PMID:31711903 NCBI chr 7:1,232,872...1,237,326
Ensembl chr 7:1,232,872...1,237,326
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 25129
    chemical entity 25100
      molecular entity 25068
        polyatomic entity 25006
          heteroatomic molecular entity 24628
            hydroxides 22948
              organic hydroxy compound 20799
                polyol 8315
                  cyclitol 2445
                    inositol 43
                      allo-inositol 0
                      chiro-inositol + 5
                      cis-inositol 0
                      epi-inositol 0
                      glycerophosphoinositol + 20
                      muco-inositol 0
                      myo-inositol + 1
                      neo-inositol 0
                      scyllo-inositol + 9
Path 2
Term Annotations click to browse term
  CHEBI ontology 25129
    subatomic particle 25090
      composite particle 25090
        hadron 25090
          baryon 25090
            nucleon 25090
              atomic nucleus 25090
                atom 25090
                  main group element atom 24969
                    p-block element atom 24969
                      chalcogen 23892
                        oxygen atom 23780
                          oxygen molecular entity 23780
                            hydroxides 22948
                              organic hydroxy compound 20799
                                polyol 8315
                                  cyclitol 2445
                                    inositol 43
                                      allo-inositol 0
                                      chiro-inositol + 5
                                      cis-inositol 0
                                      epi-inositol 0
                                      glycerophosphoinositol + 20
                                      muco-inositol 0
                                      myo-inositol + 1
                                      neo-inositol 0
                                      scyllo-inositol + 9
paths to the root