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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:inositol phosphate
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Accession:CHEBI:24846 term browser browse the term
Synonyms:related_synonym: inositol phosphates
 cyclic_relationship: is_conjugate_acid_of CHEBI:76301


show annotations for term's descendants           Sort by:
1D-myo-inositol 1,4,5-trisphosphate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adra1a adrenoceptor alpha 1A increases abundance
multiple interactions		 ISO ADRA1A protein results in increased abundance of Inositol 1,4,5-Trisphosphate
[Quinidine co-treated with Verapamil] inhibits the reaction [ADRA1A protein results in increased abundance of Inositol 1,4,5-Trisphosphate]; Quinidine inhibits the reaction [ADRA1A protein results in increased abundance of Inositol 1,4,5-Trisphosphate]; Verapamil inhibits the reaction [ADRA1A protein results in increased abundance of Inositol 1,4,5-Trisphosphate]		 CTD PMID:9570190 NCBI chr15:40,830,125...40,935,902
Ensembl chr15:40,832,534...40,927,500 		JBrowse link
G Adra1b adrenoceptor alpha 1B increases abundance
increases metabolic processing
multiple interactions		 ISO ADRA1B protein results in increased abundance of Inositol 1,4,5-Trisphosphate
ADRA1B protein results in increased metabolism of Inositol 1,4,5-Trisphosphate
[Quinidine co-treated with Verapamil] inhibits the reaction [ADRA1B protein results in increased abundance of Inositol 1,4,5-Trisphosphate]; Quinidine inhibits the reaction [ADRA1B protein results in increased abundance of Inositol 1,4,5-Trisphosphate]; Verapamil inhibits the reaction [ADRA1B protein results in increased abundance of Inositol 1,4,5-Trisphosphate]		 CTD PMID:9570190 PMID:11278430 NCBI chr10:28,255,025...28,373,418
Ensembl chr10:28,255,025...28,312,919 		JBrowse link
G Adra1d adrenoceptor alpha 1D increases abundance
multiple interactions		 ISO ADRA1D protein results in increased abundance of Inositol 1,4,5-Trisphosphate
[Quinidine co-treated with Verapamil] inhibits the reaction [ADRA1D protein results in increased abundance of Inositol 1,4,5-Trisphosphate]; Quinidine inhibits the reaction [ADRA1D protein results in increased abundance of Inositol 1,4,5-Trisphosphate]; Verapamil inhibits the reaction [ADRA1D protein results in increased abundance of Inositol 1,4,5-Trisphosphate]		 CTD PMID:9570190 NCBI chr 3:118,793,356...118,809,354
Ensembl chr 3:118,793,346...118,809,354 		JBrowse link
G Casr calcium-sensing receptor multiple interactions ISO [CASR protein mutant form results in increased susceptibility to Calcium] which results in increased abundance of Inositol 1,4,5-Trisphosphate CTD PMID:7874174 NCBI chr11:64,235,251...64,304,811
Ensembl chr11:64,235,251...64,304,811 		JBrowse link
G Cat catalase multiple interactions ISO CAT protein inhibits the reaction [Glucose promotes the reaction [EDN1 protein results in increased chemical synthesis of Inositol 1,4,5-Trisphosphate]] CTD PMID:20691780 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Chrm1 cholinergic receptor, muscarinic 1 affects abundance ISO CHRM1 protein affects the abundance of Inositol 1,4,5-Trisphosphate CTD PMID:19002953 NCBI chr 1:205,567,226...205,583,001
Ensembl chr 1:205,567,220...205,582,356 		JBrowse link
G Chrm2 cholinergic receptor, muscarinic 2 multiple interactions
increases abundance		 ISO Carbachol promotes the reaction [CHRM2 protein results in increased abundance of Inositol 1,4,5-Trisphosphate]; otenzepad inhibits the reaction [Carbachol promotes the reaction [CHRM2 protein results in increased abundance of Inositol 1,4,5-Trisphosphate]] CTD PMID:19002953 NCBI chr 4:65,015,408...65,149,104
Ensembl chr 4:65,014,144...65,149,103 		JBrowse link
G Edn1 endothelin 1 multiple interactions
increases chemical synthesis
increases abundance		 EXP
ISO		 cyclo(Trp-Asp-Pro-Val-Leu) inhibits the reaction [EDN1 protein results in increased chemical synthesis of Inositol 1,4,5-Trisphosphate]; Heparin inhibits the reaction [EDN1 protein results in increased abundance of Inositol 1,4,5-Trisphosphate]
CAT protein inhibits the reaction [Glucose promotes the reaction [EDN1 protein results in increased chemical synthesis of Inositol 1,4,5-Trisphosphate]]; diphenyleneiodonium inhibits the reaction [Glucose promotes the reaction [EDN1 protein results in increased chemical synthesis of Inositol 1,4,5-Trisphosphate]]; diphenyleneiodonium inhibits the reaction [Streptozocin promotes the reaction [EDN1 protein results in increased chemical synthesis of Inositol 1,4,5-Trisphosphate]]; Glucose promotes the reaction [EDN1 protein results in increased chemical synthesis of Inositol 1,4,5-Trisphosphate]; Streptozocin promotes the reaction [EDN1 protein results in increased chemical synthesis of Inositol 1,4,5-Trisphosphate]		 CTD PMID:1443220 PMID:11911850 PMID:20691780 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression EXP Inositol 1,4,5-Trisphosphate results in increased expression of FOS protein CTD PMID:16259952 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Gata4 GATA binding protein 4 multiple interactions
increases expression		 EXP Cyclosporine promotes the reaction [Inositol 1,4,5-Trisphosphate results in increased expression of GATA4 mRNA]; Heparin inhibits the reaction [Inositol 1,4,5-Trisphosphate results in increased expression of GATA4 protein] CTD PMID:16259952 NCBI chr15:37,459,601...37,531,291
Ensembl chr15:37,459,601...37,505,636 		JBrowse link
G Htr2b 5-hydroxytryptamine receptor 2B decreases abundance ISO HTR2B protein mutant form results in decreased abundance of Inositol 1,4,5-Trisphosphate CTD PMID:15625277 NCBI chr 9:86,735,793...86,756,638
Ensembl chr 9:86,742,102...86,755,108 		JBrowse link
G Inpp5a inositol polyphosphate-5-phosphatase A multiple interactions ISO benzene 1,2,4-trisphosphate inhibits the reaction [INPP5A protein results in increased metabolism of Inositol 1,4,5-Trisphosphate]; Polyphosphates inhibits the reaction [INPP5A protein results in increased metabolism of Inositol 1,4,5-Trisphosphate] CTD PMID:18574825 NCBI chr 1:194,190,086...194,380,429
Ensembl chr 1:194,190,393...194,380,428 		JBrowse link
G Itpr1 inositol 1,4,5-trisphosphate receptor, type 1 multiple interactions ISO Inositol 1,4,5-Trisphosphate inhibits the reaction [bisphenol A binds to ITPR1 protein] CTD PMID:33408296 NCBI chr 4:141,187,377...141,554,240
Ensembl chr 4:141,187,418...141,510,491 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor increases expression EXP Inositol 1,4,5-Trisphosphate results in increased expression of MYC protein CTD PMID:16259952 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630 		JBrowse link
G Myh7 myosin heavy chain 7 increases expression EXP Inositol 1,4,5-Trisphosphate results in increased expression of MYH7 mRNA CTD PMID:16259952 NCBI chr15:28,446,550...28,469,888
Ensembl chr15:28,446,550...28,468,217 		JBrowse link
G Nfatc3 nuclear factor of activated T-cells 3 multiple interactions
increases expression		 EXP Heparin inhibits the reaction [Inositol 1,4,5-Trisphosphate results in increased expression of NFATC3 protein] CTD PMID:16259952 NCBI chr19:33,960,643...34,035,150
Ensembl chr19:33,960,852...34,035,150 		JBrowse link
G Npy1r neuropeptide Y receptor Y1 affects abundance EXP NPY1R protein affects the abundance of Inositol 1,4,5-Trisphosphate CTD PMID:7742479 NCBI chr16:23,037,788...23,047,330
Ensembl chr16:23,037,789...23,046,759 		JBrowse link
G Npy2r neuropeptide Y receptor Y2 affects abundance EXP NPY2R protein affects the abundance of Inositol 1,4,5-Trisphosphate CTD PMID:7742479 NCBI chr 2:167,901,999...167,912,165
Ensembl chr 2:167,903,879...167,905,024 		JBrowse link
G Tnfsf4 TNF superfamily member 4 increases abundance ISO TNFSF4 protein results in increased abundance of Inositol 1,4,5-Trisphosphate CTD PMID:19416722 NCBI chr13:73,723,329...73,746,809
Ensembl chr13:73,723,329...73,746,788 		JBrowse link
1D-myo-inositol 1-phosphate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cysltr2 cysteinyl leukotriene receptor 2 multiple interactions ISO [Leukotriene D4 binds to and results in increased activity of CYSLTR2 protein] which results in increased chemical synthesis of inositol 1-phosphate CTD PMID:33288675 NCBI chr15:48,189,476...48,228,750
Ensembl chr15:48,189,073...48,304,136 		JBrowse link
G Ppargc1a PPARG coactivator 1 alpha increases expression ISO inositol 1-phosphate results in increased expression of PPARGC1A mRNA CTD PMID:23056435 NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656 		JBrowse link
myo-inositol hexakisphosphate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 decreases activity ISO Phytic Acid results in decreased activity of AKT1 protein CTD PMID:15868430 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO Phytic Acid inhibits the reaction [Asbestos, Amosite results in increased activity of CASP3 protein] CTD PMID:11329530 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp9 caspase 9 multiple interactions ISO Phytic Acid inhibits the reaction [Asbestos, Amosite results in increased activity of CASP9 protein] CTD PMID:12540492 PMID:14766669 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cat catalase multiple interactions EXP [Phytic Acid co-treated with Inositol] inhibits the reaction [Streptozocin results in decreased activity of CAT protein] CTD PMID:28757134 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Ccnd1 cyclin D1 multiple interactions ISO Phytic Acid inhibits the reaction [Urethane results in increased expression of CCND1 mRNA]; Phytic Acid inhibits the reaction [Urethane results in increased expression of CCND1 protein] CTD PMID:22797328 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phytic Acid inhibits the reaction [Glucose results in increased expression of CDKN1A mRNA]]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phytic Acid inhibits the reaction [Glucose results in increased expression of CDKN1A protein]]; Phytic Acid inhibits the reaction [Glucose results in increased expression of CDKN1A mRNA]; Phytic Acid inhibits the reaction [Glucose results in increased expression of CDKN1A protein] CTD PMID:38000455 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B decreases expression ISO Phytic Acid results in decreased expression of CDKN1B protein CTD PMID:15868430 NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982 		JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A multiple interactions
affects methylation		 ISO Phytic Acid inhibits the reaction [Ethylnitrosourea results in decreased expression of CDKN2A]
Phytic Acid affects the methylation of CDKN2A promoter		 CTD PMID:21154115 NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149 		JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phytic Acid inhibits the reaction [Glucose results in decreased expression of COL1A1 mRNA]]; Phytic Acid inhibits the reaction [Glucose results in decreased expression of COL1A1 mRNA] CTD PMID:38000455 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624 		JBrowse link
G Ctsb cathepsin B multiple interactions EXP Phytic Acid inhibits the reaction [Isoproterenol results in increased activity of CTSB protein] CTD PMID:25560919 NCBI chr15:37,389,636...37,410,508
Ensembl chr15:37,389,629...37,410,500 		JBrowse link
G Ctsd cathepsin D multiple interactions EXP Phytic Acid inhibits the reaction [Isoproterenol results in increased activity of CTSD protein] CTD PMID:25560919 NCBI chr 1:197,527,467...197,539,343
Ensembl chr 1:197,527,467...197,539,488 		JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO Phytic Acid inhibits the reaction [Asbestos, Crocidolite results in decreased phosphorylation of EGFR protein] CTD PMID:15626777 NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382 		JBrowse link
G Ehmt2 euchromatic histone lysine methyltransferase 2 multiple interactions ISO Phytic Acid inhibits the reaction [Urethane results in increased expression of EHMT2 mRNA]; Phytic Acid inhibits the reaction [Urethane results in increased expression of EHMT2 protein] CTD PMID:25168426 NCBI chr20:3,919,623...3,936,751
Ensembl chr20:3,919,624...3,941,547 		JBrowse link
G Ezh2 enhancer of zeste 2 polycomb repressive complex 2 subunit multiple interactions ISO Phytic Acid inhibits the reaction [Urethane results in increased expression of EZH2 mRNA]; Phytic Acid inhibits the reaction [Urethane results in increased expression of EZH2 protein] CTD PMID:25168426 NCBI chr 4:76,624,399...76,687,362
Ensembl chr 4:76,624,399...76,687,362 		JBrowse link
G Foxo1 forkhead box O1 multiple interactions ISO [resveratrol co-treated with Quercetin co-treated with Phytic Acid] results in increased expression of FOXO1 mRNA CTD PMID:18657603 NCBI chr 2:136,312,168...136,390,603
Ensembl chr 2:136,312,168...136,387,790 		JBrowse link
G G6pd glucose-6-phosphate dehydrogenase multiple interactions EXP [Phytic Acid co-treated with Inositol] inhibits the reaction [Streptozocin results in decreased activity of G6PD protein] CTD PMID:28757134 NCBI chr  X:152,201,081...152,220,863
Ensembl chr  X:152,201,098...152,220,801 		JBrowse link
G Glb1 galactosidase, beta 1 multiple interactions EXP
ISO		 Phytic Acid inhibits the reaction [Isoproterenol results in increased activity of GLB1 protein]
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phytic Acid inhibits the reaction [Glucose results in increased expression of GLB1 protein]]; Phytic Acid inhibits the reaction [Glucose results in increased expression of GLB1 protein]		 CTD PMID:25560919 PMID:38000455 NCBI chr 8:114,085,508...114,158,127
Ensembl chr 8:114,085,508...114,158,127 		JBrowse link
G Gusb glucuronidase, beta multiple interactions EXP Phytic Acid inhibits the reaction [Isoproterenol results in increased activity of GUSB protein] CTD PMID:25560919 NCBI chr12:26,701,188...26,714,718
Ensembl chr12:26,697,951...26,726,905 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Phytic Acid inhibits the reaction [Glucose results in increased expression of IL1B protein] CTD PMID:38000455 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO Phytic Acid inhibits the reaction [Urethane results in increased expression of IL6 mRNA]; Phytic Acid inhibits the reaction [Urethane results in increased expression of IL6 protein] CTD PMID:22797328 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases activity
multiple interactions		 ISO
EXP		 Phytic Acid results in decreased activity of MAPK1 protein
[resveratrol co-treated with Phytic Acid co-treated with ferulic acid co-treated with Quercetin] results in increased phosphorylation of MAPK1 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phytic Acid inhibits the reaction [Glucose results in increased phosphorylation of MAPK1 protein]]; Phytic Acid inhibits the reaction [Glucose results in increased phosphorylation of MAPK1 protein]		 CTD PMID:15868430 PMID:21203465 PMID:38000455 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases activity
multiple interactions		 ISO
EXP		 Phytic Acid results in decreased activity of MAPK3 protein
[resveratrol co-treated with Phytic Acid co-treated with ferulic acid co-treated with Quercetin] results in increased phosphorylation of MAPK3 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phytic Acid inhibits the reaction [Glucose results in increased phosphorylation of MAPK3 protein]]; Phytic Acid inhibits the reaction [Glucose results in increased phosphorylation of MAPK3 protein]		 CTD PMID:15868430 PMID:21203465 PMID:38000455 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mir101a microRNA 101a multiple interactions EXP [resveratrol co-treated with Phytic Acid co-treated with ferulic acid co-treated with Quercetin] results in increased expression of MIR101A mRNA CTD PMID:21203465 NCBI chr 5:115,966,332...115,966,406
Ensembl chr 5:115,966,328...115,966,410 		JBrowse link
G Mir10a microRNA 10a multiple interactions EXP [resveratrol co-treated with Phytic Acid co-treated with ferulic acid co-treated with Quercetin] results in increased expression of MIR10A mRNA CTD PMID:21203465 NCBI chr10:81,283,171...81,283,280
Ensembl chr10:81,283,171...81,283,280 		JBrowse link
G Mir138-1 microRNA 138-1 multiple interactions ISO Phytic Acid inhibits the reaction [Urethane results in decreased expression of MIR138-1 mRNA] CTD PMID:25168426 NCBI chr 8:122,300,966...122,301,064
Ensembl chr 8:122,300,966...122,301,064 		JBrowse link
G Mir181c microRNA 181c multiple interactions EXP [resveratrol co-treated with Phytic Acid co-treated with ferulic acid co-treated with Quercetin] results in increased expression of MIR181C mRNA CTD PMID:21203465 NCBI chr19:23,983,523...23,983,628
Ensembl chr19:23,983,523...23,983,628 		JBrowse link
G Mir20b microRNA 20b multiple interactions EXP [resveratrol co-treated with Phytic Acid co-treated with ferulic acid co-treated with Quercetin] results in decreased expression of MIR20B mRNA CTD PMID:21203465 NCBI chr  X:132,422,211...132,422,282
Ensembl chr  X:132,422,211...132,422,282 		JBrowse link
G Mir21 microRNA 21 multiple interactions EXP [resveratrol co-treated with Phytic Acid co-treated with ferulic acid co-treated with Quercetin] results in increased expression of MIR21 mRNA CTD PMID:21203465 NCBI chr10:71,405,257...71,405,348
Ensembl chr10:71,405,257...71,405,348 		JBrowse link
G Mir214 microRNA 214 multiple interactions EXP [Resveratrol co-treated with Phytic Acid co-treated with ferulic acid co-treated with Quercetin] results in increased expression of MIR214 mRNA CTD PMID:21203465 NCBI chr13:74,588,374...74,588,481
Ensembl chr13:74,588,372...74,588,481 		JBrowse link
G Mir25 microRNA 25 multiple interactions EXP [resveratrol co-treated with Phytic Acid co-treated with ferulic acid co-treated with Quercetin] results in increased expression of MIR25 mRNA CTD PMID:21203465 NCBI chr12:17,042,932...17,043,015
Ensembl chr12:17,042,932...17,043,015 		JBrowse link
G Mir27b microRNA 27b multiple interactions EXP [resveratrol co-treated with Phytic Acid co-treated with ferulic acid co-treated with Quercetin] results in decreased expression of MIR27B mRNA CTD PMID:21203465 NCBI chr17:1,813,427...1,813,523
Ensembl chr17:1,813,426...1,813,529 		JBrowse link
G Mir324 microRNA 324 multiple interactions EXP [resveratrol co-treated with Phytic Acid co-treated with ferulic acid co-treated with Quercetin] results in increased expression of MIR324 mRNA CTD PMID:21203465 NCBI chr10:54,734,680...54,734,762
Ensembl chr10:54,734,678...54,734,766 		JBrowse link
G Mir339 microRNA 339 multiple interactions EXP [resveratrol co-treated with Phytic Acid co-treated with ferulic acid co-treated with Quercetin] results in increased expression of MIR339 mRNA CTD PMID:21203465 NCBI chr12:15,277,546...15,277,641
Ensembl chr12:15,277,546...15,277,641 		JBrowse link
G Mir450a1 microRNA 450a-1 multiple interactions EXP [resveratrol co-treated with Phytic Acid co-treated with ferulic acid co-treated with Quercetin] results in increased expression of MIR450A1 mRNA CTD PMID:21203465 NCBI chr  X:132,801,380...132,801,470
Ensembl chr  X:132,801,380...132,801,470 		JBrowse link
G Mir760 microRNA 760 multiple interactions EXP [resveratrol co-treated with Phytic Acid co-treated with ferulic acid co-treated with Quercetin] results in increased expression of MIR760 mRNA CTD PMID:21203465 NCBI chr 2:210,392,616...210,392,695
Ensembl chr 2:210,392,616...210,392,695 		JBrowse link
G Mlh1 mutL homolog 1 multiple interactions
affects methylation		 ISO Phytic Acid inhibits the reaction [Ethylnitrosourea results in increased expression of MLH1]
Phytic Acid affects the methylation of MLH1 promoter		 CTD PMID:21154115 NCBI chr 8:111,196,468...111,233,721
Ensembl chr 8:111,196,468...111,233,617 		JBrowse link
G Naglu N-acetyl-alpha-glucosaminidase multiple interactions EXP Phytic Acid inhibits the reaction [Isoproterenol results in increased activity of NAGLU protein] CTD PMID:25560919 NCBI chr10:86,001,545...86,009,049
Ensembl chr10:86,001,566...86,008,972 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions ISO Phytic Acid inhibits the reaction [Glucose results in decreased expression of NFE2L2 protein] CTD PMID:38000455 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO Phytic Acid inhibits the reaction [Urethane results in decreased expression of NFKB1 mRNA]; Phytic Acid inhibits the reaction [Urethane results in decreased expression of NFKB1 protein]; Phytic Acid inhibits the reaction [Urethane results in increased expression of NFKB1 mRNA]; Phytic Acid inhibits the reaction [Urethane results in increased expression of NFKB1 protein] CTD PMID:22797328 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO Phytic Acid inhibits the reaction [Asbestos, Amosite results in increased activity of PARP1 protein]; Phytic Acid inhibits the reaction [Smoke analog results in increased activity of PARP1 protein] CTD PMID:11217149 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Pdk4 pyruvate dehydrogenase kinase 4 multiple interactions ISO [resveratrol co-treated with Quercetin co-treated with Phytic Acid] results in increased expression of PDK4 mRNA CTD PMID:18657603 NCBI chr 4:33,591,796...33,601,798
Ensembl chr 4:33,589,799...33,601,850 		JBrowse link
G Ppargc1a PPARG coactivator 1 alpha multiple interactions ISO [resveratrol co-treated with Quercetin co-treated with Phytic Acid] results in increased expression of PPARGC1A mRNA CTD PMID:18657603 NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656 		JBrowse link
G Prkcd protein kinase C, delta multiple interactions ISO Phytic Acid results in increased expression of and results in increased activity of and affects the localization of PRKCD protein CTD PMID:15868430 NCBI chr16:5,769,217...5,799,380
Ensembl chr16:5,769,215...5,799,352 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
affects methylation		 ISO Phytic Acid inhibits the reaction [Ethylnitrosourea results in increased expression of PTGS2]; Phytic Acid inhibits the reaction [Urethane results in increased expression of PTGS2 mRNA]; Phytic Acid inhibits the reaction [Urethane results in increased expression of PTGS2 protein]
Phytic Acid affects the methylation of PTGS2 promoter		 CTD PMID:21154115 PMID:22797328 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Rb1 RB transcriptional corepressor 1 decreases phosphorylation ISO Phytic Acid results in decreased phosphorylation of RB1 protein CTD PMID:15868430 NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO Phytic Acid inhibits the reaction [Urethane results in increased expression of RELA mRNA]; Phytic Acid inhibits the reaction [Urethane results in increased expression of RELA protein]
Phytic Acid inhibits the reaction [Glucose results in increased phosphorylation of RELA protein]		 CTD PMID:22797328 PMID:38000455 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Runx2 RUNX family transcription factor 2 multiple interactions ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phytic Acid inhibits the reaction [Glucose results in decreased expression of RUNX2 mRNA]]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phytic Acid inhibits the reaction [Glucose results in decreased expression of RUNX2 protein]]; Phytic Acid inhibits the reaction [Glucose results in decreased expression of RUNX2 mRNA]; Phytic Acid inhibits the reaction [Glucose results in decreased expression of RUNX2 protein] CTD PMID:38000455 NCBI chr 9:16,167,504...16,492,826
Ensembl chr 9:16,167,482...16,492,167 		JBrowse link
G Spp1 secreted phosphoprotein 1 multiple interactions ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phytic Acid inhibits the reaction [Glucose results in decreased expression of SPP1 mRNA]]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phytic Acid inhibits the reaction [Glucose results in decreased expression of SPP1 protein]]; Phytic Acid inhibits the reaction [Glucose results in decreased expression of SPP1 mRNA]; Phytic Acid inhibits the reaction [Glucose results in decreased expression of SPP1 protein] CTD PMID:38000455 NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO Phytic Acid inhibits the reaction [Urethane results in increased expression of and results in increased phosphorylation of STAT3 protein]; Phytic Acid inhibits the reaction [Urethane results in increased expression of STAT3 mRNA] CTD PMID:22797328 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057 		JBrowse link
G Suv39h1 SUV39H1 histone lysine methyltransferase multiple interactions ISO Phytic Acid inhibits the reaction [Urethane results in increased expression of SUV39H1 mRNA]; Phytic Acid inhibits the reaction [Urethane results in increased expression of SUV39H1 protein] CTD PMID:25168426 NCBI chr  X:14,421,028...14,433,993
Ensembl chr  X:14,421,109...14,433,982 		JBrowse link
G Suv39h1-ps1 SUV39H1 histone lysine methyltransferase, pseudogene 1 multiple interactions ISO Phytic Acid inhibits the reaction [Urethane results in increased expression of SUV39H1 mRNA]; Phytic Acid inhibits the reaction [Urethane results in increased expression of SUV39H1 protein] CTD PMID:25168426 NCBI chr  X:141,792,589...141,795,257 JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions ISO Phytic Acid inhibits the reaction [Glucose results in increased expression of TLR4 protein] CTD PMID:38000455 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Phytic Acid inhibits the reaction [Glucose results in increased expression of TNF protein] CTD PMID:38000455 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO
EXP		 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phytic Acid inhibits the reaction [Glucose results in increased expression of TP53 mRNA]]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phytic Acid inhibits the reaction [Glucose results in increased expression of TP53 protein]]; Phytic Acid inhibits the reaction [Asbestos, Amosite results in increased expression of TP53 mRNA]; Phytic Acid inhibits the reaction [Asbestos, Amosite results in increased expression of TP53 protein]; Phytic Acid inhibits the reaction [Glucose results in increased expression of TP53 mRNA]; Phytic Acid inhibits the reaction [Glucose results in increased expression of TP53 protein] CTD PMID:16357363 PMID:38000455 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Ucp3 uncoupling protein 3 multiple interactions ISO [resveratrol co-treated with Quercetin co-treated with Phytic Acid] results in increased expression of UCP3 mRNA CTD PMID:18657603 NCBI chr 1:154,815,777...154,828,764
Ensembl chr 1:154,815,777...154,828,762 		JBrowse link
G Xdh xanthine dehydrogenase decreases activity EXP Phytic Acid results in decreased activity of XDH protein CTD PMID:14738912 NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19811
    role 19818
      application 19630
        NMR chemical shift reference compound 17936
          phosphoric acid 11417
            phosphoric acid derivative 11226
              organic phosphate 11225
                cyclitol phosphate 75
                  inositol phosphate 75
                    3-(3-(1,2-dihydroxy-1,2-dihexanoyl)thiopropane)inositol-4,5-diphosphate 0
                    D-myo-inositol-1,2,3,5,6-pentaphosphate 0
                    D-myo-inositol-1,4,6-triphosphate 0
                    D-myo-inositol-1,4-diphosphate 0
                    Diphosphoinositol tetrakisphosphate 0
                    Inositol 1,3,4,5-tetraphosphate 0
                    Inositol 4-phosphate 0
                    L-myo-inositol-1,4,5-triphosphate 0
                    Manpbeta1-2inositol1-phospho-ceramide 0
                    bis(1L-myo-inositol) 3,1'-phosphate 1-phosphate 0
                    diphosphoinositol polyphosphate + 0
                    myo-inositol phosphate + 75
                    scyllo-inositol phosphate + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19811
    subatomic particle 19809
      composite particle 19809
        hadron 19840
          baryon 19809
            nucleon 19809
              atomic nucleus 19809
                atom 19809
                  main group element atom 19759
                    p-block element atom 19759
                      chalcogen 19515
                        oxygen atom 19520
                          oxygen molecular entity 19490
                            hydroxides 19300
                              oxoacid 18725
                                pnictogen oxoacid 13221
                                  phosphorus oxoacid 12413
                                    phosphoric acids 11427
                                      phosphoric acid 11417
                                        phosphoric acid derivative 11226
                                          phosphate 11225
                                            organic phosphate 11225
                                              cyclitol phosphate 75
                                                inositol phosphate 75
                                                  3-(3-(1,2-dihydroxy-1,2-dihexanoyl)thiopropane)inositol-4,5-diphosphate 0
                                                  D-myo-inositol-1,2,3,5,6-pentaphosphate 0
                                                  D-myo-inositol-1,4,6-triphosphate 0
                                                  D-myo-inositol-1,4-diphosphate 0
                                                  Diphosphoinositol tetrakisphosphate 0
                                                  Inositol 1,3,4,5-tetraphosphate 0
                                                  Inositol 4-phosphate 0
                                                  L-myo-inositol-1,4,5-triphosphate 0
                                                  Manpbeta1-2inositol1-phospho-ceramide 0
                                                  bis(1L-myo-inositol) 3,1'-phosphate 1-phosphate 0
                                                  diphosphoinositol polyphosphate + 0
                                                  myo-inositol phosphate + 75
                                                  scyllo-inositol phosphate + 0
paths to the root