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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:indoledione
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Accession:CHEBI:24793 term browser browse the term
Synonyms:related_synonym: Formula=C8H5NO2


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isatin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1b1 aldo-keto reductase family 1 member B increases reduction ISO AKR1B1 protein results in increased reduction of Isatin CTD PMID:10510318 NCBI chr 4:62,932,033...62,946,126 JBrowse link
G Akr1b8 aldo-keto reductase family 1, member B8 multiple interactions EXP [AKR1B8 protein co-treated with NADP] affects the reduction of Isatin CTD PMID:18845131 NCBI chr 4:62,997,241...63,009,815 JBrowse link
G Akr7a2 aldo-keto reductase family 7, member A2 affects reduction
increases reduction
ISO Isatin affects the reduction of AKR7A5 protein
AKR7A2 protein results in increased reduction of Isatin
CTD PMID:10510318 PMID:12604212 NCBI chr 5:151,552,375...151,560,914 JBrowse link
G Casp3 caspase 3 multiple interactions ISO [Copper binds to Isatin binds to 2-(2-aminoethyl)pyridine] which results in increased cleavage of CASP3 protein; [Copper binds to Isatin binds to trimethylenediamine] which results in increased cleavage of CASP3 protein CTD PMID:17327230 NCBI chr16:45,662,910...45,681,171 JBrowse link
G Casp9 caspase 9 multiple interactions ISO [Copper binds to Isatin binds to 2-(2-aminoethyl)pyridine] which results in increased cleavage of CASP9 protein; [Copper binds to Isatin binds to trimethylenediamine] which results in increased cleavage of CASP9 protein CTD PMID:17327230 NCBI chr 5:154,108,872...154,126,628 JBrowse link
G Cbr1 carbonyl reductase 1 multiple interactions ISO [S-Nitrosoglutathione binds to CBR1 protein] promotes the reaction [CBR1 protein results in increased metabolism of Isatin] CTD PMID:23295225 NCBI chr11:32,860,618...32,862,981 JBrowse link
G Cbr3 carbonyl reductase 3 increases metabolic processing ISO CBR3 protein results in increased metabolism of Isatin CTD PMID:19061875 NCBI chr11:33,008,615...33,016,877 JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions ISO [Copper binds to Isatin binds to 2-(2-aminoethyl)pyridine] which results in increased expression of CDKN1A protein; [Copper binds to Isatin binds to trimethylenediamine] which results in increased expression of CDKN1A protein; Tretinoin inhibits the reaction [[Copper binds to Isatin binds to trimethylenediamine] which results in increased expression of CDKN1A protein] CTD PMID:17327230 NCBI chr20:7,149,177...7,159,727 JBrowse link
G Cycs cytochrome c, somatic multiple interactions ISO [Copper binds to Isatin binds to 2-(2-aminoethyl)pyridine] which affects the localization of CYCS protein; [Copper binds to Isatin binds to trimethylenediamine] which affects the localization of CYCS protein CTD PMID:17327230 NCBI chr 4:79,651,894...79,653,994 JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 increases expression ISO Isatin results in increased expression of CYP2D6 mRNA CTD PMID:15056799 NCBI chr 7:113,882,584...113,891,754 JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 increases expression ISO Isatin results in increased expression of CYP2E1 mRNA CTD PMID:15056799 NCBI chr 1:195,840,330...195,850,728 JBrowse link
G Dhrs11 dehydrogenase/reductase 11 increases reduction ISO DHRS11 protein results in increased reduction of Isatin CTD PMID:30926317 NCBI chr10:69,698,214...69,708,294 JBrowse link
G Dhrs7 dehydrogenase/reductase 7 increases reduction ISO DHRS7 protein results in increased reduction of Isatin CTD PMID:24246760 NCBI chr 6:91,332,259...91,347,856 JBrowse link
G Il10 interleukin 10 multiple interactions EXP Isatin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of IL10] CTD PMID:24316276 NCBI chr13:42,472,625...42,477,308 JBrowse link
G Mpo myeloperoxidase multiple interactions EXP Isatin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of MPO] CTD PMID:24316276 NCBI chr10:72,594,458...72,608,862 JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP Isatin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of PTGS2] CTD PMID:24316276 NCBI chr13:62,164,080...62,169,770 JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions ISO SOD1 protein results in decreased susceptibility to [Copper binds to Isatin binds to 2-(2-aminoethyl)pyridine]; SOD1 protein results in decreased susceptibility to [Copper binds to Isatin binds to trimethylenediamine] CTD PMID:17327230 NCBI chr11:29,456,673...29,462,249 JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP Isatin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TNF] CTD PMID:24316276 NCBI chr20:3,622,011...3,624,629 JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO [Copper binds to Isatin binds to 2-(2-aminoethyl)pyridine] which results in increased expression of TP53 protein; [Copper binds to Isatin binds to trimethylenediamine] which results in increased expression of TP53 protein; Tretinoin inhibits the reaction [[Copper binds to Isatin binds to trimethylenediamine] which results in increased expression of TP53 protein] CTD PMID:17327230 NCBI chr10:54,300,070...54,311,525 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19762
    chemical entity 19762
      atom 19760
        nonmetal atom 19641
          nitrogen atom 18634
            nitrogen molecular entity 18634
              organonitrogen compound 18386
                organonitrogen heterocyclic compound 17585
                  benzopyrrole 9553
                    indoles 9227
                      indolones 5855
                        indoledione 19
                          5-(6-aminohexanamido)isatin 0
                          5-aminoisatin 0
                          6-(3'-methylbuten-2-yl)isatin 0
                          N-acetylisatin 0
                          betanidin quinone 0
                          indole-4,7-quinone 0
                          indole-5,6-quinone 0
                          isatin + 19
Path 2
Term Annotations click to browse term
  CHEBI ontology 19762
    subatomic particle 19760
      composite particle 19760
        hadron 19760
          baryon 19760
            nucleon 19760
              atomic nucleus 19760
                atom 19760
                  main group element atom 19651
                    p-block element atom 19651
                      carbon group element atom 19570
                        carbon atom 19560
                          organic molecular entity 19560
                            organic molecule 19493
                              organic cyclic compound 19322
                                organic heterocyclic compound 18554
                                  organic heteropolycyclic compound 18048
                                    organic heterobicyclic compound 16841
                                      benzopyrrole 9553
                                        indoles 9227
                                          indolones 5855
                                            indoledione 19
                                              5-(6-aminohexanamido)isatin 0
                                              5-aminoisatin 0
                                              6-(3'-methylbuten-2-yl)isatin 0
                                              N-acetylisatin 0
                                              betanidin quinone 0
                                              indole-4,7-quinone 0
                                              indole-5,6-quinone 0
                                              isatin + 19
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