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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:imine
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Accession:CHEBI:24783 term browser browse the term
Definition:Compounds having the structure RN=CR2 (R = H, hydrocarbyl). Thus analogues of aldehydes or ketones, having NR doubly bonded to carbon; aldimines have the structure RCH=NR, ketimines have the structure R'2C=NR (where R' is not H). Imines include azomethines and Schiff bases. Imine is used as a suffix in systematic nomenclature to denote the C=NH group excluding the carbon atom.
Synonyms:related_synonym: Formula=CNR3;   SMILES=[*]\\C([*])=N\\[*];   imines



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2,6-dichloroindophenol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2l1 BCL2-like 1 multiple interactions ISO [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in decreased expression of BCL2L1 mRNA CTD PMID:21034357 NCBI chr 2:152,600,652...152,673,632
Ensembl chr 2:152,622,588...152,673,648
JBrowse link
G Ccl4 C-C motif chemokine ligand 4 multiple interactions ISO [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of CCL4 mRNA CTD PMID:21034357 NCBI chr11:83,553,410...83,555,509
Ensembl chr11:83,553,410...83,555,509
JBrowse link
G Cdkn1a cyclin dependent kinase inhibitor 1A multiple interactions ISO [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of CDKN1A mRNA; [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of CDKN1A protein CTD PMID:21034357 NCBI chr17:29,309,953...29,319,696
Ensembl chr17:29,309,950...29,319,701
JBrowse link
G Cntf ciliary neurotrophic factor multiple interactions ISO 2,6-Dichloroindophenol inhibits the reaction [Cadmium Chloride inhibits the reaction [CNTF results in increased phosphorylation of STAT1 protein]]; 2,6-Dichloroindophenol inhibits the reaction [Cadmium Chloride inhibits the reaction [CNTF results in increased phosphorylation of STAT3 protein]] CTD PMID:19635391 NCBI chr19:12,740,892...12,742,996
Ensembl chr19:12,741,024...12,742,996
JBrowse link
G Cryab crystallin, alpha B multiple interactions ISO [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of CRYAB mRNA CTD PMID:21034357 NCBI chr 9:50,657,251...50,667,936
Ensembl chr 9:50,662,625...50,667,936
JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 multiple interactions ISO [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of CXCL10 mRNA CTD PMID:21034357 NCBI chr 5:92,494,497...92,496,748
Ensembl chr 5:92,494,497...92,496,748
JBrowse link
G Egr1 early growth response 1 multiple interactions ISO [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of EGR1 mRNA CTD PMID:21034357 NCBI chr18:34,994,260...34,998,009
Ensembl chr18:34,992,876...34,998,037
JBrowse link
G Ephx2 epoxide hydrolase 2, cytoplasmic multiple interactions ISO [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of EPHX2 mRNA CTD PMID:21034357 NCBI chr14:66,321,821...66,361,971
Ensembl chr14:66,321,823...66,361,949
JBrowse link
G Fasl Fas ligand multiple interactions ISO [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of FASLG mRNA CTD PMID:21034357 NCBI chr 1:161,608,260...161,616,064
Ensembl chr 1:161,608,258...161,616,064
JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible 45 alpha multiple interactions ISO [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of GADD45A mRNA CTD PMID:21034357 NCBI chr 6:67,012,080...67,014,391
Ensembl chr 6:67,012,080...67,014,441
JBrowse link
G Gdf15 growth differentiation factor 15 multiple interactions ISO [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of GDF15 mRNA CTD PMID:21034357 NCBI chr 8:71,082,043...71,085,106
Ensembl chr 8:71,082,043...71,085,106
JBrowse link
G Gstm5 glutathione S-transferase, mu 5 multiple interactions ISO [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of GSTM3 mRNA CTD PMID:21034357 NCBI chr 3:107,803,240...107,806,002
Ensembl chr 3:107,803,137...107,806,002
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of HMOX1 mRNA; [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of HMOX1 protein CTD PMID:21034357 NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217
JBrowse link
G Hspa1a heat shock protein 1A multiple interactions ISO [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of HSPA1A mRNA; [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of HSPA1A protein CTD PMID:21034357 NCBI chr17:35,188,335...35,191,132
Ensembl chr17:35,188,166...35,191,132
JBrowse link
G Hspa2 heat shock protein 2 multiple interactions ISO [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of HSPA2 mRNA CTD PMID:21034357 NCBI chr12:76,450,688...76,453,712
Ensembl chr12:76,450,950...76,453,712
JBrowse link
G Lta lymphotoxin A multiple interactions ISO [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of LTA mRNA CTD PMID:21034357 NCBI chr17:35,422,141...35,424,568
Ensembl chr17:35,422,141...35,424,327
JBrowse link
G Nos2 nitric oxide synthase 2, inducible multiple interactions ISO [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of NOS2 mRNA CTD PMID:21034357 NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080
JBrowse link
G Nqo1 NAD(P)H dehydrogenase, quinone 1 multiple interactions
increases response to substance
increases reduction
ISO [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in decreased expression of BCL2L1 mRNA; [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of CCL4 mRNA; [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of CDKN1A mRNA; [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of CDKN1A protein; [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of CRYAB mRNA; [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of CXCL10 mRNA; [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of EGR1 mRNA; [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of EPHX2 mRNA; [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of FASLG mRNA; [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of GADD45A mRNA; [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of GDF15 mRNA; [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of GSTM3 mRNA; [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of HMOX1 mRNA; [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of HMOX1 protein; [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of HSPA1A mRNA; [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of HSPA1A protein; [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of HSPA2 mRNA; [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of HSPA6 mRNA; [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of HSPA6 protein; [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of LTA mRNA; [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of NOS2 mRNA; [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of TNF mRNA; [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased phosphorylation of TP53 protein; Carbamazepine inhibits the reaction [NQO1 protein results in increased reduction of 2,6-Dichloroindophenol]; Diclofenac inhibits the reaction [NQO1 protein results in increased reduction of 2,6-Dichloroindophenol]; Dicumarol inhibits the reaction [NQO1 protein results in increased reduction of 2,6-Dichloroindophenol]; Mefenamic Acid inhibits the reaction [NQO1 protein results in increased reduction of 2,6-Dichloroindophenol]; NQO1 protein inhibits the reaction [2,6-Dichloroindophenol results in decreased abundance of Glutathione]; NQO1 protein polymorphism promotes the reaction [2,6-Dichloroindophenol results in decreased abundance of Glutathione]; Tacrine inhibits the reaction [NQO1 protein results in increased reduction of 2,6-Dichloroindophenol]
NQO1 protein polymorphism results in increased susceptibility to 2,6-Dichloroindophenol
CTD PMID:21034357 PMID:29281794 NCBI chr 8:108,114,856...108,139,012
Ensembl chr 8:108,114,857...108,129,838
JBrowse link
G Nqo2 N-ribosyldihydronicotinamide quinone reductase 2 multiple interactions
increases reduction
ISO [NQO2 protein results in increased oxidation of 1-benzyl-1,4-dihydronicotinamide] which results in increased reduction of 2,6-Dichloroindophenol; [NQO2 protein results in increased oxidation of nicotinamide-beta-riboside] which results in increased reduction of 2,6-Dichloroindophenol; resveratrol inhibits the reaction [NQO2 protein results in increased reduction of 2,6-Dichloroindophenol]; Tacrine inhibits the reaction [NQO2 protein results in increased reduction of 2,6-Dichloroindophenol] CTD PMID:20399199 PMID:29281794 NCBI chr13:34,148,642...34,172,448
Ensembl chr13:34,148,670...34,172,426
JBrowse link
G Stat1 signal transducer and activator of transcription 1 multiple interactions ISO 2,6-Dichloroindophenol inhibits the reaction [Cadmium Chloride inhibits the reaction [CNTF results in increased phosphorylation of STAT1 protein]] CTD PMID:19635391 NCBI chr 1:52,158,588...52,201,024
Ensembl chr 1:52,158,599...52,201,024
JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO 2,6-Dichloroindophenol inhibits the reaction [Cadmium Chloride inhibits the reaction [CNTF results in increased phosphorylation of STAT3 protein]] CTD PMID:19635391 NCBI chr11:100,777,632...100,830,447
Ensembl chr11:100,775,924...100,830,366
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of TNF mRNA CTD PMID:21034357 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983
JBrowse link
G Trp53 transformation related protein 53 multiple interactions ISO [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased phosphorylation of TP53 protein CTD PMID:21034357 NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699
JBrowse link
5,5-dimethyl-1-pyrroline N-oxide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alb albumin multiple interactions ISO [NOS1 co-treated with sodium sulfite co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased oxidation of ALB protein CTD PMID:20348042 NCBI chr 5:90,608,729...90,624,461
Ensembl chr 5:90,608,756...90,624,461
JBrowse link
G Mpo myeloperoxidase multiple interactions ISO 4'-hydroxydiclofenac promotes the reaction [[Hydrogen Peroxide co-treated with MPO protein co-treated with Glutathione] results in increased glutathionylation of 5,5-dimethyl-1-pyrroline-1-oxide]; [[Hydrogen Peroxide results in increased activity of MPO protein] which results in increased oxidation of Glutathione] which results in increased glutathionylation of 5,5-dimethyl-1-pyrroline-1-oxide; [[MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 2,4-dichloroaniline] which results in increased expression of MPO protein modified form; [[MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 2,4-xylidine] which results in increased expression of MPO protein modified form; [[MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 2,6-xylidine] which results in increased expression of MPO protein modified form; [[MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 2-anisidine] which results in increased expression of MPO protein modified form; [[MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 2-chloroaniline] which results in increased expression of MPO protein modified form; [[MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 2-toluidine] which results in increased expression of MPO protein modified form; [[MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 3,4-dichloroaniline] which results in increased expression of MPO protein modified form; [[MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 3,4-xylidine] which results in increased expression of MPO protein modified form; [[MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 3-anisidine] which results in increased expression of MPO protein modified form; [[MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 3-chloroaniline] which results in increased expression of MPO protein modified form; [[MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 3-toluidine] which results in increased expression of MPO protein modified form; [[MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 4-aminobenzonitrile] which results in increased expression of MPO protein modified form; [[MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 4-chloroaniline] which results in increased expression of MPO protein modified form; [[MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 4-ethylaniline] which results in increased expression of MPO protein modified form; [[MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 4-fluoroaniline] which results in increased expression of MPO protein modified form; [[MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 4-nitroaniline] which results in increased expression of MPO protein modified form; [[MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 4-toluidine] which results in increased expression of MPO protein modified form; [[MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of Aminoglutethimide] which results in increased expression of MPO protein modified form; [[MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of aniline] which results in increased expression of MPO protein modified form; [[MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of Procainamide] which results in increased expression of MPO protein modified form; [Hydrogen Peroxide co-treated with MPO protein co-treated with Glutathione] results in increased glutathionylation of 5,5-dimethyl-1-pyrroline-1-oxide; [MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 2,4-dichloroaniline; [MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 2,4-xylidine; [MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 2,6-xylidine; [MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 2-anisidine; [MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 2-chloroaniline; [MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 2-toluidine; [MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 3,4-dichloroaniline; [MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 3,4-xylidine; [MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 3-anisidine; [MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 3-chloroaniline; [MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 3-toluidine; [MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 4-aminobenzonitrile; [MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 4-chloroaniline; [MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 4-ethylaniline; [MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 4-fluoroaniline; [MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 4-nitroaniline; [MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 4-toluidine; [MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of Aminoglutethimide; [MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of aniline; [MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of Procainamide; desmethylnaproxen promotes the reaction [[Hydrogen Peroxide co-treated with MPO protein co-treated with Glutathione] results in increased glutathionylation of 5,5-dimethyl-1-pyrroline-1-oxide] CTD PMID:20199096 PMID:28754375 NCBI chr11:87,684,610...87,695,238
Ensembl chr11:87,684,407...87,695,239
JBrowse link
G Nos1 nitric oxide synthase 1, neuronal multiple interactions ISO [NOS1 co-treated with sodium sulfite co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased oxidation of ALB protein CTD PMID:20348042 NCBI chr 5:118,004,904...118,096,905
Ensembl chr 5:117,919,097...118,096,905
JBrowse link
Bandrowski's base term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1b1 aldo-keto reductase family 1 member B increases expression ISO Bandrowski's base results in increased expression of AKR1B1 mRNA CTD PMID:20566472 NCBI chr 6:34,280,865...34,294,424
Ensembl chr 6:34,279,369...34,294,413
JBrowse link
G Akr1b10 aldo-keto reductase family 1, member B10 increases expression ISO Bandrowski's base results in increased expression of AKR1B10 mRNA CTD PMID:20566472 NCBI chr 6:34,361,182...34,373,884
Ensembl chr 6:34,361,153...34,373,885
JBrowse link
G Akr1c18 aldo-keto reductase family 1, member C18 increases expression ISO Bandrowski's base results in increased expression of AKR1C3 mRNA CTD PMID:20566472 NCBI chr13:4,182,614...4,200,645
Ensembl chr13:4,182,614...4,200,653
JBrowse link
G Akr1c20 aldo-keto reductase family 1, member C20 increases expression ISO Bandrowski's base results in increased expression of AKR1C1 mRNA CTD PMID:20566472 NCBI chr13:4,536,855...4,573,353
Ensembl chr13:4,536,848...4,573,344
JBrowse link
G Cat catalase increases expression ISO Bandrowski's base results in increased expression of CAT mRNA CTD PMID:20566472 NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505
JBrowse link
G Ccl17 C-C motif chemokine ligand 17 affects expression ISO Bandrowski's base affects the expression of CCL17 mRNA CTD PMID:18202158 NCBI chr 8:95,535,996...95,538,666
Ensembl chr 8:95,537,081...95,538,664
JBrowse link
G Ccl22 C-C motif chemokine ligand 22 affects expression ISO Bandrowski's base affects the expression of CCL22 mRNA CTD PMID:18202158 NCBI chr 8:95,472,312...95,478,016
Ensembl chr 8:95,472,218...95,478,327
JBrowse link
G Ccl4 C-C motif chemokine ligand 4 affects expression ISO Bandrowski's base affects the expression of CCL4 mRNA CTD PMID:18202158 NCBI chr11:83,553,410...83,555,509
Ensembl chr11:83,553,410...83,555,509
JBrowse link
G Ccr7 C-C motif chemokine receptor 7 affects expression
increases expression
ISO Bandrowski's base affects the expression of CCR7 mRNA
Bandrowski's base results in increased expression of CCR7 protein
CTD PMID:18202158 PMID:19665512 NCBI chr11:99,035,025...99,045,903
Ensembl chr11:99,035,022...99,045,903
JBrowse link
G Cd80 CD80 antigen increases expression ISO Bandrowski's base results in increased expression of CD80 protein CTD PMID:31958493 NCBI chr16:38,277,793...38,316,682
Ensembl chr16:38,275,923...38,316,697
JBrowse link
G Cd86 CD86 antigen affects expression
multiple interactions
increases expression
ISO Bandrowski's base affects the expression of CD86 mRNA
MIR146A affects the reaction [Bandrowski's base results in increased expression of CD86 protein]; PRKCB protein affects the reaction [Bandrowski's base results in increased expression of CD86 protein]
CTD PMID:18202158 PMID:19665512 PMID:21742781 PMID:31958493 PMID:37326882 NCBI chr16:36,389,318...36,486,439
Ensembl chr16:36,424,231...36,486,443
JBrowse link
G Cxcl15 C-X-C motif chemokine ligand 15 affects expression ISO Bandrowski's base affects the expression of CXCL8 mRNA CTD PMID:18202158 NCBI chr 5:90,942,393...90,950,926
Ensembl chr 5:90,942,393...90,950,926
JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 affects expression ISO Bandrowski's base affects the expression of CXCR4 mRNA CTD PMID:18202158 NCBI chr 1:128,515,936...128,520,036
Ensembl chr 1:128,515,936...128,520,030
JBrowse link
G Fech ferrochelatase increases expression ISO Bandrowski's base results in increased expression of FECH mRNA CTD PMID:20566472 NCBI chr18:64,589,613...64,622,169
Ensembl chr18:64,585,985...64,623,322
JBrowse link
G Ftl1 ferritin light polypeptide 1 increases expression ISO Bandrowski's base results in increased expression of FTL mRNA CTD PMID:20566472 NCBI chr 7:45,107,368...45,109,310
Ensembl chr 7:45,107,368...45,109,308
JBrowse link
G G6pdx glucose-6-phosphate dehydrogenase X-linked increases expression ISO Bandrowski's base results in increased expression of G6PD mRNA CTD PMID:20566472 NCBI chr  X:73,453,089...73,472,486
Ensembl chr  X:73,453,089...73,472,800
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression ISO Bandrowski's base results in increased expression of GCLC mRNA CTD PMID:20566472 NCBI chr 9:77,661,817...77,701,771
Ensembl chr 9:77,661,817...77,701,767
JBrowse link
G Gclm glutamate-cysteine ligase, modifier subunit increases expression ISO Bandrowski's base results in increased expression of GCLM mRNA CTD PMID:20566472 NCBI chr 3:122,039,206...122,060,864
Ensembl chr 3:122,039,206...122,064,381
JBrowse link
G Gpx3 glutathione peroxidase 3 increases expression ISO Bandrowski's base results in increased expression of GPX3 mRNA CTD PMID:20566472 NCBI chr11:54,793,680...54,801,213
Ensembl chr11:54,793,279...54,801,203
JBrowse link
G Gsr glutathione reductase increases expression ISO Bandrowski's base results in increased expression of GSR mRNA CTD PMID:20566472 NCBI chr 8:34,143,266...34,188,190
Ensembl chr 8:34,142,551...34,188,191
JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO Bandrowski's base results in increased expression of HMOX1 mRNA CTD PMID:20566472 NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217
JBrowse link
G Icam1 intercellular adhesion molecule 1 increases expression
affects expression
ISO Bandrowski's base results in increased expression of ICAM1 protein
Bandrowski's base affects the expression of ICAM1 mRNA
CTD PMID:18202158 PMID:21742781 NCBI chr 9:20,927,236...20,940,110
Ensembl chr 9:20,927,281...20,940,113
JBrowse link
G Maff v-maf musculoaponeurotic fibrosarcoma oncogene family, protein F (avian) increases expression ISO Bandrowski's base results in increased expression of MAFF mRNA CTD PMID:20566472 NCBI chr15:79,230,813...79,243,278
Ensembl chr15:79,230,821...79,243,276
JBrowse link
G Mafg v-maf musculoaponeurotic fibrosarcoma oncogene family, protein G (avian) increases expression ISO Bandrowski's base results in increased expression of MAFG mRNA CTD PMID:20566472 NCBI chr11:120,515,943...120,525,771
Ensembl chr11:120,515,943...120,524,426
JBrowse link
G Mafk v-maf musculoaponeurotic fibrosarcoma oncogene family, protein K (avian) increases expression ISO Bandrowski's base results in increased expression of MAFK mRNA CTD PMID:20566472 NCBI chr 5:139,777,291...139,788,409
Ensembl chr 5:139,777,268...139,788,408
JBrowse link
G Me1 malic enzyme 1, NADP(+)-dependent, cytosolic increases expression ISO Bandrowski's base results in increased expression of ME1 mRNA CTD PMID:20566472 NCBI chr 9:86,463,416...86,577,967
Ensembl chr 9:86,463,424...86,578,006
JBrowse link
G Mgst1 microsomal glutathione S-transferase 1 increases expression ISO Bandrowski's base results in increased expression of MGST1 mRNA CTD PMID:20566472 NCBI chr 6:138,117,525...138,133,753
Ensembl chr 6:138,117,314...138,133,753
JBrowse link
G Mir146 microRNA 146 multiple interactions ISO MIR146A affects the reaction [Bandrowski's base results in increased expression of CD86 protein] CTD PMID:37326882 NCBI chr11:43,265,224...43,265,288
Ensembl chr11:43,265,224...43,265,288
JBrowse link
G Mir155 microRNA 155 increases expression ISO Bandrowski's base results in increased expression of MIR155 mRNA CTD PMID:32939143 NCBI chr16:84,511,028...84,511,092
Ensembl chr16:84,511,028...84,511,092
JBrowse link
G Mir21a microRNA 21a decreases expression ISO Bandrowski's base results in decreased expression of MIR21 mRNA CTD PMID:32939143 NCBI chr11:86,474,893...86,474,984
Ensembl chr11:86,474,893...86,474,984
JBrowse link
G Mt1 metallothionein 1 increases expression ISO Bandrowski's base results in increased expression of MT1X mRNA CTD PMID:20566472 NCBI chr 8:94,905,214...94,906,955
Ensembl chr 8:94,905,710...94,906,955
JBrowse link
G Nqo1 NAD(P)H dehydrogenase, quinone 1 increases expression ISO Bandrowski's base results in increased expression of NQO1 mRNA CTD PMID:20566472 NCBI chr 8:108,114,856...108,139,012
Ensembl chr 8:108,114,857...108,129,838
JBrowse link
G Pgd phosphogluconate dehydrogenase increases expression ISO Bandrowski's base results in increased expression of PGD mRNA CTD PMID:20566472 NCBI chr 4:149,234,448...149,251,162
Ensembl chr 4:149,234,448...149,251,228
JBrowse link
G Ppia peptidylprolyl isomerase A affects expression ISO Bandrowski's base affects the expression of PPIA mRNA CTD PMID:18202158 NCBI chr11:6,365,867...6,369,817
Ensembl chr11:6,365,443...6,369,817
JBrowse link
G Prkcb protein kinase C, beta increases expression
multiple interactions
ISO Bandrowski's base results in increased expression of PRKCB protein
PRKCB protein affects the reaction [Bandrowski's base results in increased expression of CD86 protein]
CTD PMID:31958493 PMID:37326882 NCBI chr 7:121,888,327...122,233,625
Ensembl chr 7:121,887,974...122,233,625
JBrowse link
G Ptgr1 prostaglandin reductase 1 increases expression ISO Bandrowski's base results in increased expression of PTGR1 mRNA CTD PMID:20566472 NCBI chr 4:58,965,590...58,987,131
Ensembl chr 4:58,965,439...58,987,119
JBrowse link
G Sod1 superoxide dismutase 1, soluble increases expression ISO Bandrowski's base results in increased expression of SOD1 mRNA CTD PMID:20566472 NCBI chr16:90,017,650...90,023,221
Ensembl chr16:90,017,642...90,023,217
JBrowse link
G Sod2 superoxide dismutase 2, mitochondrial increases expression ISO Bandrowski's base results in increased expression of SOD2 mRNA CTD PMID:20566472 NCBI chr17:13,226,726...13,237,006
Ensembl chr17:13,225,733...13,258,950
JBrowse link
G Sod3 superoxide dismutase 3, extracellular increases expression ISO Bandrowski's base results in increased expression of SOD3 mRNA CTD PMID:20566472 NCBI chr 5:52,521,146...52,527,080
Ensembl chr 5:52,521,133...52,528,760
JBrowse link
G Srxn1 sulfiredoxin 1 homolog (S. cerevisiae) increases expression ISO Bandrowski's base results in increased expression of SRXN1 mRNA CTD PMID:20566472 NCBI chr 2:151,946,738...151,953,296
Ensembl chr 2:151,947,436...151,953,296
JBrowse link
G Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a affects expression ISO Bandrowski's base affects the expression of TNFRSF1A mRNA CTD PMID:18202158 NCBI chr 6:125,326,686...125,339,446
Ensembl chr 6:125,326,325...125,339,447
JBrowse link
G Txn2 thioredoxin 2 increases expression ISO Bandrowski's base results in increased expression of TXN2 mRNA CTD PMID:20566472 NCBI chr15:77,799,251...77,813,194
Ensembl chr15:77,799,247...77,813,206
JBrowse link
G Txnrd1 thioredoxin reductase 1 increases expression ISO Bandrowski's base results in increased expression of TXNRD1 mRNA CTD PMID:20566472 NCBI chr10:82,669,785...82,733,558
Ensembl chr10:82,669,785...82,733,546
JBrowse link
G Txnrd2 thioredoxin reductase 2 increases expression ISO Bandrowski's base results in increased expression of TXNRD2 mRNA CTD PMID:20566472 NCBI chr16:18,245,167...18,297,823
Ensembl chr16:18,245,134...18,297,823
JBrowse link
G Ugt1a6b UDP glucuronosyltransferase 1 family, polypeptide A6B increases expression ISO Bandrowski's base results in increased expression of UGT1A6 mRNA CTD PMID:20566472 NCBI chr 1:88,030,979...88,146,720
Ensembl chr 1:88,030,974...88,146,725
JBrowse link
N-acetyl-1,4-benzoquinone imine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G 4930453N24Rik RIKEN cDNA 4930453N24 gene affects response to substance ISO C3ORF38 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr16:64,583,267...64,592,735
Ensembl chr16:64,572,114...64,591,524
JBrowse link
G Acta2 actin alpha 2, smooth muscle, aorta increases expression
multiple interactions
ISO N-acetyl-4-benzoquinoneimine results in increased expression of ACTA2 mRNA; N-acetyl-4-benzoquinoneimine results in increased expression of ACTA2 protein
andrographolide inhibits the reaction [N-acetyl-4-benzoquinoneimine results in increased expression of ACTA2 mRNA]; andrographolide inhibits the reaction [N-acetyl-4-benzoquinoneimine results in increased expression of ACTA2 protein]
CTD PMID:28286204 PMID:29355602 NCBI chr19:34,217,736...34,232,985
Ensembl chr19:34,218,490...34,232,990
JBrowse link
G Adarb2 adenosine deaminase, RNA-specific, B2 affects response to substance ISO ADARB2 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr13:8,252,475...8,818,798
Ensembl chr13:8,252,902...8,818,783
JBrowse link
G Alcam activated leukocyte cell adhesion molecule affects response to substance ISO ALCAM gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr16:52,069,359...52,273,444
Ensembl chr16:52,069,359...52,274,437
JBrowse link
G Aldh1a3 aldehyde dehydrogenase family 1, subfamily A3 affects response to substance ISO ALDH1A3 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr 7:66,040,640...66,077,225
Ensembl chr 7:66,040,638...66,077,265
JBrowse link
G Bmp2 bone morphogenetic protein 2 increases expression ISO N-acetyl-4-benzoquinoneimine results in increased expression of BMP2 mRNA CTD PMID:28286204 NCBI chr 2:133,394,079...133,404,816
Ensembl chr 2:133,394,079...133,404,805
JBrowse link
G Bpnt2 3'(2'), 5'-bisphosphate nucleotidase 2 affects response to substance ISO BPNT2 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr 4:4,762,484...4,793,306
Ensembl chr 4:4,762,484...4,793,355
JBrowse link
G Cacna1h calcium channel, voltage-dependent, T type, alpha 1H subunit affects response to substance ISO CACNA1H gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr17:25,593,259...25,655,308
Ensembl chr17:25,593,259...25,652,759
JBrowse link
G Cald1 caldesmon 1 affects response to substance ISO CALD1 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr 6:34,575,433...34,752,404
Ensembl chr 6:34,575,435...34,752,408
JBrowse link
G Ccdc25 coiled-coil domain containing 25 affects response to substance ISO CCDC25 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr14:66,074,751...66,104,053
Ensembl chr14:66,074,751...66,104,056
JBrowse link
G Cd9 CD9 antigen affects response to substance ISO CD9 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr 6:125,437,229...125,471,723
Ensembl chr 6:125,437,229...125,471,754
JBrowse link
G Cep44 centrosomal protein 44 affects response to substance ISO CEP44 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr 8:56,983,516...57,010,052
Ensembl chr 8:56,984,557...57,004,082
JBrowse link
G Cnr1 cannabinoid receptor 1 affects response to substance ISO CNR1 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr 4:33,923,171...33,948,831
Ensembl chr 4:33,924,593...33,948,831
JBrowse link
G Col1a1 collagen, type I, alpha 1 increases expression
multiple interactions
ISO N-acetyl-4-benzoquinoneimine results in increased expression of COL1A1 mRNA
andrographolide inhibits the reaction [N-acetyl-4-benzoquinoneimine results in increased expression of COL1A1 mRNA]
CTD PMID:28286204 PMID:29355602 NCBI chr11:94,827,050...94,843,868
Ensembl chr11:94,827,050...94,843,868
JBrowse link
G Col1a2 collagen, type I, alpha 2 increases expression ISO N-acetyl-4-benzoquinoneimine results in increased expression of COL1A2 mRNA CTD PMID:28286204 NCBI chr 6:4,505,618...4,541,543
Ensembl chr 6:4,504,814...4,541,544
JBrowse link
G Col3a1 collagen, type III, alpha 1 increases expression
multiple interactions
ISO N-acetyl-4-benzoquinoneimine results in increased expression of COL3A1 mRNA
andrographolide inhibits the reaction [N-acetyl-4-benzoquinoneimine results in increased expression of COL3A1 mRNA]
CTD PMID:28286204 PMID:29355602 NCBI chr 1:45,350,698...45,388,866
Ensembl chr 1:45,350,698...45,388,866
JBrowse link
G Cpa6 carboxypeptidase A6 affects response to substance ISO CPA6 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr 1:10,366,016...10,790,277
Ensembl chr 1:10,394,945...10,790,170
JBrowse link
G Cst5 cystatin D affects response to substance ISO CST5 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr 2:149,247,242...149,252,217
Ensembl chr 2:149,246,977...149,252,213
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions
increases abundance
EXP
ISO
CYP1A2 protein results in increased chemical synthesis of and results in increased abundance of N-acetyl-4-benzoquinoneimine
CYP1A2 protein results in increased abundance of N-acetyl-4-benzoquinoneimine
CTD PMID:19679878 PMID:24661219 NCBI chr 9:57,584,220...57,590,938
Ensembl chr 9:57,584,220...57,590,986
JBrowse link
G Cyp2d22 cytochrome P450, family 2, subfamily d, polypeptide 22 increases abundance ISO CYP2D6 protein results in increased abundance of N-acetyl-4-benzoquinoneimine CTD PMID:24661219 NCBI chr15:82,254,728...82,264,461
Ensembl chr15:82,254,728...82,264,461
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions
increases abundance
increases chemical synthesis
EXP
ISO
CYP2E1 protein results in increased chemical synthesis of and results in increased abundance of N-acetyl-4-benzoquinoneimine
CYP2E1 protein results in increased abundance of N-acetyl-4-benzoquinoneimine
CYP2E1 results in increased chemical synthesis of N-acetyl-4-benzoquinoneimine
CTD PMID:19679878 PMID:20566340 PMID:24661219 NCBI chr 7:140,343,732...140,354,903
Ensembl chr 7:140,343,652...140,354,900
JBrowse link
G Dmrt1 doublesex and mab-3 related transcription factor 1 affects response to substance ISO DMRT1 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr19:25,483,070...25,581,692
Ensembl chr19:25,482,982...25,581,693
JBrowse link
G Dnttip1 deoxynucleotidyltransferase, terminal, interacting protein 1 affects response to substance ISO DNTTIP1 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr 2:164,587,935...164,610,140
Ensembl chr 2:164,587,903...164,610,527
JBrowse link
G Dsc3 desmocollin 3 affects response to substance ISO DSC3 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr18:20,093,987...20,135,465
Ensembl chr18:20,093,987...20,135,408
JBrowse link
G Etnk2 ethanolamine kinase 2 affects response to substance ISO ETNK2 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr 1:133,291,308...133,308,056
Ensembl chr 1:133,291,310...133,308,074
JBrowse link
G Fbxo39 F-box protein 39 affects response to substance ISO FBXO39 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr11:72,205,270...72,210,245
Ensembl chr11:72,205,270...72,210,242
JBrowse link
G Frk fyn-related kinase affects response to substance ISO FRK gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr10:34,359,396...34,487,530
Ensembl chr10:34,359,395...34,487,274
JBrowse link
G Gpx1 glutathione peroxidase 1 multiple interactions
affects response to substance
EXP [GPX1 protein co-treated with SOD1 protein] affects the susceptibility to N-acetyl-4-benzoquinoneimine
GPX1 protein affects the susceptibility to N-acetyl-4-benzoquinoneimine
CTD PMID:16636302 NCBI chr 9:108,216,279...108,217,541
Ensembl chr 9:108,216,102...108,217,542
JBrowse link
G Gstp1 glutathione S-transferase, pi 1 affects metabolic processing
multiple interactions
increases glutathionylation
increases metabolic processing
ISO GSTP1 protein polymorphism affects the metabolism of N-acetyl-4-benzoquinoneimine metabolite
NQO1 protein inhibits the reaction [GSTP1 protein results in increased glutathionylation of N-acetyl-4-benzoquinoneimine]
GSTP1 protein results in increased metabolism of N-acetyl-4-benzoquinoneimine
CTD PMID:24185126 PMID:24552538 NCBI chr19:4,085,411...4,087,912
Ensembl chr19:4,085,407...4,087,985
JBrowse link
G Hdac4 histone deacetylase 4 affects response to substance ISO HDAC4 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr 1:91,856,501...92,123,424
Ensembl chr 1:91,856,501...92,123,421
JBrowse link
G Hid1 HID1 domain containing affects response to substance ISO HID1 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr11:115,238,531...115,261,087
Ensembl chr11:115,238,533...115,258,582
JBrowse link
G Il23r interleukin 23 receptor affects response to substance ISO IL23R gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr 6:67,399,906...67,468,838
Ensembl chr 6:67,399,916...67,468,839
JBrowse link
G Kcnj3 potassium inwardly-rectifying channel, subfamily J, member 3 affects response to substance ISO KCNJ3 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr 2:55,301,814...55,488,157
Ensembl chr 2:55,325,982...55,488,157
JBrowse link
G Kcnu1 potassium channel, subfamily U, member 1 affects response to substance ISO KCNU1 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr 8:26,338,656...26,427,971
Ensembl chr 8:26,339,651...26,427,967
JBrowse link
G Keap1 kelch-like ECH-associated protein 1 multiple interactions
affects metabolic processing
EXP KEAP1 protein inhibits the reaction [NQO1 protein results in increased metabolism of N-acetyl-4-benzoquinoneimine]
N-acetyl-4-benzoquinoneimine affects the metabolism of KEAP1 protein
CTD PMID:18785192 PMID:19246624 NCBI chr 9:21,141,026...21,150,628
Ensembl chr 9:21,141,026...21,150,657
JBrowse link
G Lama4 laminin, alpha 4 affects response to substance ISO LAMA4 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr10:38,841,511...38,986,184
Ensembl chr10:38,841,511...38,986,184
JBrowse link
G Lmx1a LIM homeobox transcription factor 1 alpha affects response to substance ISO LMX1A gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr 1:167,515,864...167,676,310
Ensembl chr 1:167,516,806...167,676,310
JBrowse link
G Magi2 membrane associated guanylate kinase, WW and PDZ domain containing 2 affects response to substance ISO MAGI2 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr 5:19,431,787...20,909,790
Ensembl chr 5:19,432,034...20,909,790
JBrowse link
G Mapk1 mitogen-activated protein kinase 1 increases phosphorylation ISO N-acetyl-4-benzoquinoneimine results in increased phosphorylation of MAPK1 protein CTD PMID:28286204 NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317
JBrowse link
G Mapk3 mitogen-activated protein kinase 3 increases phosphorylation ISO N-acetyl-4-benzoquinoneimine results in increased phosphorylation of MAPK3 protein CTD PMID:28286204 NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991
JBrowse link
G Mctp1 multiple C2 domains, transmembrane 1 affects response to substance ISO MCTP1 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr13:76,530,481...77,181,403
Ensembl chr13:76,532,259...77,179,929
JBrowse link
G Mfsd4a major facilitator superfamily domain containing 4A affects response to substance ISO MFSD4A gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr 1:131,947,543...131,997,400
Ensembl chr 1:131,950,544...131,995,800
JBrowse link
G Mir135a-2 microRNA 135a-2 affects response to substance ISO MIR135A2 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr10:91,907,948...91,908,047
Ensembl chr10:91,907,948...91,908,047
JBrowse link
G Mmp2 matrix metallopeptidase 2 increases expression ISO N-acetyl-4-benzoquinoneimine results in increased expression of MMP2 mRNA CTD PMID:28286204 NCBI chr 8:93,553,920...93,580,049
Ensembl chr 8:93,553,919...93,580,048
JBrowse link
G Mtus2 microtubule associated tumor suppressor candidate 2 affects response to substance ISO MTUS2 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr 5:147,894,085...148,252,875
Ensembl chr 5:147,894,130...148,252,875
JBrowse link
G Neb nebulin affects response to substance ISO NEB gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr 2:52,026,652...52,228,810
Ensembl chr 2:52,026,659...52,268,486
JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 affects localization
multiple interactions
increases activity
EXP N-acetyl-4-benzoquinoneimine affects the localization of NFE2L2 protein
NFE2L2 protein affects the reaction [N-acetyl-4-benzoquinoneimine results in increased expression of NQO1 mRNA]; NFE2L2 protein promotes the reaction [NQO1 protein results in increased metabolism of N-acetyl-4-benzoquinoneimine]
N-acetyl-4-benzoquinoneimine results in increased activity of NFE2L2 protein
CTD PMID:18785192 PMID:19246624 NCBI chr 2:75,505,860...75,535,007
Ensembl chr 2:75,505,857...75,534,985
JBrowse link
G Nhlrc3 NHL repeat containing 3 affects response to substance ISO NHLRC3 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr 3:53,359,417...53,370,679
Ensembl chr 3:53,356,004...53,370,753
JBrowse link
G Nqo1 NAD(P)H dehydrogenase, quinone 1 multiple interactions
increases reduction
increases metabolic processing
increases expression
EXP
ISO
KEAP1 protein inhibits the reaction [NQO1 protein results in increased metabolism of N-acetyl-4-benzoquinoneimine]; NFE2L2 protein affects the reaction [N-acetyl-4-benzoquinoneimine results in increased expression of NQO1 mRNA]; NFE2L2 protein promotes the reaction [NQO1 protein results in increased metabolism of N-acetyl-4-benzoquinoneimine]
NQO1 protein inhibits the reaction [GSTP1 protein results in increased glutathionylation of N-acetyl-4-benzoquinoneimine]
NQO1 protein results in increased reduction of N-acetyl-4-benzoquinoneimine
CTD PMID:17188792 PMID:18785192 PMID:19246624 PMID:24552538 NCBI chr 8:108,114,856...108,139,012
Ensembl chr 8:108,114,857...108,129,838
JBrowse link
G Nqo2 N-ribosyldihydronicotinamide quinone reductase 2 multiple interactions ISO NQO2 protein results in increased reduction of and results in decreased glutathionylation of N-acetyl-4-benzoquinoneimine; Tacrine inhibits the reaction [NQO2 protein results in increased reduction of N-acetyl-4-benzoquinoneimine] CTD PMID:29281794 NCBI chr13:34,148,642...34,172,448
Ensembl chr13:34,148,670...34,172,426
JBrowse link
G Pcbd2 pterin 4 alpha carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) 2 affects response to substance ISO PCBD2 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr13:55,874,957...55,924,643
Ensembl chr13:55,875,181...55,924,643
JBrowse link
G Pvt1 Pvt1 oncogene affects response to substance ISO PVT1 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr15:61,909,835...62,132,064
Ensembl chr15:61,909,817...62,249,945
JBrowse link
G Rab3il1 RAB3A interacting protein (rabin3)-like 1 affects response to substance ISO RAB3IL1 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr19:9,979,033...10,015,744
Ensembl chr19:9,979,033...10,015,744
JBrowse link
G Rap1gap2 RAP1 GTPase activating protein 2 affects response to substance ISO RAP1GAP2 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr11:74,274,182...74,501,796
Ensembl chr11:74,274,182...74,501,741
JBrowse link
G Slc39a11 solute carrier family 39 (metal ion transporter), member 11 affects response to substance ISO SLC39A11 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr11:113,135,677...113,541,050
Ensembl chr11:113,135,679...113,540,905
JBrowse link
G Slit2 slit guidance ligand 2 affects response to substance ISO SLIT2 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr 5:48,138,633...48,465,077
Ensembl chr 5:48,140,480...48,465,075
JBrowse link
G Snx16 sorting nexin 16 affects response to substance ISO SNX16 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr 3:10,482,877...10,505,194
Ensembl chr 3:10,482,877...10,505,162
JBrowse link
G Sod1 superoxide dismutase 1, soluble multiple interactions EXP [GPX1 protein co-treated with SOD1 protein] affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:16636302 NCBI chr16:90,017,650...90,023,221
Ensembl chr16:90,017,642...90,023,217
JBrowse link
G Spag16 sperm associated antigen 16 affects response to substance ISO SPAG16 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr 1:69,866,031...70,764,291
Ensembl chr 1:69,866,129...70,764,291
JBrowse link
G Stab1 stabilin 1 affects response to substance ISO STAB1 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr14:30,860,974...30,890,616
Ensembl chr14:30,860,970...30,890,598
JBrowse link
G Syne3 spectrin repeat containing, nuclear envelope family member 3 affects response to substance ISO SYNE3 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr12:104,896,192...104,976,357
Ensembl chr12:104,896,192...104,976,068
JBrowse link
G Tac1 tachykinin 1 increases secretion ISO N-acetyl-4-benzoquinoneimine results in increased secretion of TAC1 protein CTD PMID:20720158 NCBI chr 6:7,555,061...7,562,978
Ensembl chr 6:7,554,879...7,565,834
JBrowse link
G Tgfb1 transforming growth factor, beta 1 increases expression ISO N-acetyl-4-benzoquinoneimine results in increased expression of TGFB1 mRNA CTD PMID:28286204 NCBI chr 7:25,386,406...25,404,503
Ensembl chr 7:25,386,427...25,404,502
JBrowse link
G Timp1 tissue inhibitor of metalloproteinase 1 increases expression ISO N-acetyl-4-benzoquinoneimine results in increased expression of TIMP1 mRNA CTD PMID:28286204 NCBI chr  X:20,736,524...20,740,972
Ensembl chr  X:20,736,405...20,740,974
JBrowse link
G Top2a topoisomerase (DNA) II alpha decreases activity ISO N-acetyl-4-benzoquinoneimine results in decreased activity of TOP2A protein CTD PMID:15035644 NCBI chr11:98,883,773...98,915,037
Ensembl chr11:98,883,769...98,915,015
JBrowse link
G Tpd52l1 tumor protein D52-like 1 affects response to substance ISO TPD52L1 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr10:31,208,369...31,321,989
Ensembl chr10:31,208,372...31,321,954
JBrowse link
G Trpa1 transient receptor potential cation channel, subfamily A, member 1 increases activity
affects response to substance
multiple interactions
ISO
EXP
N-acetyl-4-benzoquinoneimine results in increased activity of TRPA1 protein
TRPA1 affects the susceptibility to N-acetyl-4-benzoquinoneimine
2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide inhibits the reaction [N-acetyl-4-benzoquinoneimine results in increased activity of TRPA1 protein]
CTD PMID:20720158 NCBI chr 1:14,942,868...14,989,086
Ensembl chr 1:14,942,872...14,989,086
JBrowse link
G Txnrd1 thioredoxin reductase 1 decreases activity
multiple interactions
ISO N-acetyl-4-benzoquinoneimine results in decreased activity of TXNRD1 protein
Glutathione inhibits the reaction [N-acetyl-4-benzoquinoneimine results in decreased activity of TXNRD1 protein]
CTD PMID:24661219 NCBI chr10:82,669,785...82,733,558
Ensembl chr10:82,669,785...82,733,546
JBrowse link
G Ubash3a ubiquitin associated and SH3 domain containing, A affects response to substance ISO UBASH3A gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr17:31,426,842...31,478,655
Ensembl chr17:31,426,847...31,465,866
JBrowse link
G Ube2e2 ubiquitin-conjugating enzyme E2E 2 affects response to substance ISO UBE2E2 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr14:3,575,429...3,896,133
Ensembl chr14:3,575,429...3,896,121
JBrowse link
G Vwc2 von Willebrand factor C domain containing 2 affects response to substance ISO VWC2 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr11:11,063,836...11,219,295
Ensembl chr11:11,064,223...11,218,931
JBrowse link
G Wfdc3 WAP four-disulfide core domain 3 affects response to substance ISO WFDC3 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr 2:164,573,222...164,587,914
Ensembl chr 2:164,573,100...164,587,851
JBrowse link
pararosaniline free base term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bche butyrylcholinesterase decreases activity ISO pararosaniline results in decreased activity of BCHE protein CTD PMID:16036213 NCBI chr 3:73,543,138...73,615,767
Ensembl chr 3:73,543,141...73,615,748
JBrowse link
G Gstp1 glutathione S-transferase, pi 1 multiple interactions ISO pararosaniline inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate] CTD PMID:23769903 NCBI chr19:4,085,411...4,087,912
Ensembl chr19:4,085,407...4,087,985
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 decreases expression
decreases activity
ISO pararosaniline results in decreased expression of NR3C1 protein
pararosaniline results in decreased activity of NR3C1 protein
CTD PMID:19255438 NCBI chr18:39,543,598...39,652,485
Ensembl chr18:39,543,598...39,652,474
JBrowse link
sirtinol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acaca acetyl-Coenzyme A carboxylase alpha multiple interactions ISO sirtinol inhibits the reaction [S-allylcysteine results in increased phosphorylation of ACACA protein] CTD PMID:23465592 NCBI chr11:84,020,461...84,292,477
Ensembl chr11:84,020,498...84,292,477
JBrowse link
G Ahr aryl-hydrocarbon receptor multiple interactions ISO AHR mutant form inhibits the reaction [sirtinol results in increased expression of CYP1A1 mRNA]; AHR mutant form inhibits the reaction [sirtinol results in increased expression of NQO1 mRNA] CTD PMID:22495798 NCBI chr12:35,547,978...35,584,988
Ensembl chr12:35,547,973...35,585,037
JBrowse link
G Akt1 thymoma viral proto-oncogene 1 multiple interactions EXP sirtinol inhibits the reaction [resveratrol inhibits the reaction [Doxorubicin results in decreased phosphorylation of AKT1 protein]] CTD PMID:26450947 NCBI chr12:112,620,260...112,641,266
Ensembl chr12:112,620,255...112,641,318
JBrowse link
G App amyloid beta precursor protein multiple interactions EXP sirtinol inhibits the reaction [cilostazol inhibits the reaction [APP protein results in decreased expression of and results in decreased activity of SIRT1 protein]] CTD PMID:24254769 NCBI chr16:84,751,236...84,972,187
Ensembl chr16:84,746,573...84,970,654
JBrowse link
G Bax BCL2-associated X protein multiple interactions EXP
ISO
sirtinol inhibits the reaction [resveratrol inhibits the reaction [Doxorubicin results in increased expression of BAX protein]]
sirtinol inhibits the reaction [rhodioloside inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of BAX protein]]; sirtinol promotes the reaction [cudraflavone B results in increased expression of BAX protein]
CTD PMID:23881456 PMID:25665036 PMID:26450947 PMID:28851138 NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322
JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 multiple interactions ISO sirtinol inhibits the reaction [rhodioloside inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of BCL2 protein]]; sirtinol promotes the reaction [cudraflavone B results in decreased expression of BCL2 protein] CTD PMID:23881456 PMID:28851138 NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004
JBrowse link
G Casp3 caspase 3 multiple interactions ISO
EXP
sirtinol inhibits the reaction [Resveratrol results in increased activity of CASP3 protein]; sirtinol inhibits the reaction [rhodioloside inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased activity of CASP3 protein]]; sirtinol promotes the reaction [cudraflavone B results in increased activity of CASP3 protein]
sirtinol inhibits the reaction [resveratrol inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein]]; sirtinol results in increased cleavage of and results in increased activity of CASP3 protein
sirtinol inhibits the reaction [resveratrol inhibits the reaction [Hydrogen Peroxide results in increased expression of CASP3 protein modified form]]; sirtinol promotes the reaction [Hydrogen Peroxide results in increased expression of CASP3 protein modified form]
CTD PMID:20697895 PMID:23881456 PMID:24889822 PMID:25665036 PMID:26251326 More... NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724
JBrowse link
G Casp9 caspase 9 multiple interactions ISO sirtinol inhibits the reaction [resveratrol results in increased activity of CASP9 protein] CTD PMID:20697895 NCBI chr 4:141,520,923...141,543,289
Ensembl chr 4:141,520,923...141,543,287
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO sirtinol inhibits the reaction [resveratrol inhibits the reaction [IL1B protein results in increased expression of CCL2 mRNA]] CTD PMID:20531350 NCBI chr11:81,926,403...81,928,278
Ensembl chr11:81,926,397...81,928,279
JBrowse link
G Ccl20 C-C motif chemokine ligand 20 increases expression ISO sirtinol results in increased expression of CCL20 mRNA CTD PMID:22385246 NCBI chr 1:83,094,487...83,096,888
Ensembl chr 1:83,094,487...83,096,888
JBrowse link
G Cd40 CD40 antigen multiple interactions EXP sirtinol promotes the reaction [TNF protein results in increased expression of CD40 mRNA] CTD PMID:22717288 NCBI chr 2:164,897,535...164,913,574
Ensembl chr 2:164,897,547...164,914,868
JBrowse link
G Cdkn1a cyclin dependent kinase inhibitor 1A increases expression
multiple interactions
ISO sirtinol results in increased expression of CDKN1A mRNA; sirtinol results in increased expression of CDKN1A protein
sirtinol promotes the reaction [cudraflavone B results in increased expression of CDKN1A protein]
CTD PMID:22495798 PMID:23881456 NCBI chr17:29,309,953...29,319,696
Ensembl chr17:29,309,950...29,319,701
JBrowse link
G Cdkn1b cyclin dependent kinase inhibitor 1B multiple interactions ISO sirtinol promotes the reaction [cudraflavone B results in increased expression of CDKN1B protein] CTD PMID:23881456 NCBI chr 6:134,897,364...134,902,488
Ensembl chr 6:134,897,364...134,902,476
JBrowse link
G Col10a1 collagen, type X, alpha 1 decreases expression EXP sirtinol results in decreased expression of COL10A1 protein CTD PMID:26251326 NCBI chr10:34,265,977...34,273,081
Ensembl chr10:34,265,977...34,273,081
JBrowse link
G Col1a1 collagen, type I, alpha 1 decreases expression EXP sirtinol results in decreased expression of COL1A1 protein CTD PMID:26251326 NCBI chr11:94,827,050...94,843,868
Ensembl chr11:94,827,050...94,843,868
JBrowse link
G Col2a1 collagen, type II, alpha 1 decreases expression EXP sirtinol results in decreased expression of COL2A1 protein CTD PMID:26251326 NCBI chr15:97,873,483...97,902,525
Ensembl chr15:97,873,483...97,902,576
JBrowse link
G Cxcl15 C-X-C motif chemokine ligand 15 increases expression ISO sirtinol results in increased expression of CXCL8 mRNA CTD PMID:22385246 NCBI chr 5:90,942,393...90,950,926
Ensembl chr 5:90,942,393...90,950,926
JBrowse link
G Cyba cytochrome b-245, alpha polypeptide increases expression ISO sirtinol results in increased expression of CYBA mRNA CTD PMID:23422569 NCBI chr 8:123,151,510...123,159,679
Ensembl chr 8:123,151,515...123,159,669
JBrowse link
G Cybb cytochrome b-245, beta polypeptide multiple interactions ISO sirtinol inhibits the reaction [rhodioloside inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of CYBB protein]] CTD PMID:28851138 NCBI chr  X:9,301,493...9,354,005
Ensembl chr  X:9,301,491...9,354,010
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression
multiple interactions
ISO sirtinol results in increased expression of CYP1A1 mRNA
AHR mutant form inhibits the reaction [sirtinol results in increased expression of CYP1A1 mRNA]
CTD PMID:22495798 NCBI chr 9:57,595,211...57,611,107
Ensembl chr 9:57,595,211...57,611,107
JBrowse link
G Ep300 E1A binding protein p300 multiple interactions EXP sirtinol inhibits the reaction [cilostazol affects the expression of EP300 protein]; sirtinol inhibits the reaction [resveratrol inhibits the reaction [Doxorubicin results in increased expression of EP300 protein]] CTD PMID:24254769 PMID:25665036 NCBI chr15:81,470,329...81,536,273
Ensembl chr15:81,469,552...81,536,278
JBrowse link
G F3 coagulation factor III multiple interactions ISO sirtinol promotes the reaction [TNF protein results in increased expression of F3 mRNA]; sirtinol promotes the reaction [TNF protein results in increased expression of F3 protein] CTD PMID:20978007 NCBI chr 3:121,517,186...121,528,701
Ensembl chr 3:121,517,186...121,528,697
JBrowse link
G Fbxo32 F-box protein 32 multiple interactions ISO [sirtinol results in decreased activity of SIRT1 protein] which results in decreased expression of FBXO32 mRNA CTD PMID:22146233 NCBI chr15:58,039,275...58,078,288
Ensembl chr15:58,039,275...58,078,328
JBrowse link
G Foxo1 forkhead box O1 multiple interactions
increases acetylation
EXP
ISO
sirtinol inhibits the reaction [resveratrol inhibits the reaction [Doxorubicin results in increased acetylation of FOXO1 protein]]
sirtinol results in increased acetylation of FOXO1 protein
sirtinol inhibits the reaction [resveratrol inhibits the reaction [Hydrogen Peroxide results in increased acetylation of FOXO1 protein]]; sirtinol promotes the reaction [Hydrogen Peroxide results in increased acetylation of FOXO1 protein]
CTD PMID:24889822 PMID:25665036 NCBI chr 3:52,175,758...52,257,530
Ensembl chr 3:52,175,757...52,260,642
JBrowse link
G Gh growth hormone multiple interactions
increases secretion
increases expression
ISO sirtinol inhibits the reaction [resveratrol results in decreased secretion of GH1 protein]
sirtinol results in increased secretion of GH1 protein
sirtinol results in increased expression of GH1 mRNA
CTD PMID:23292070 NCBI chr11:106,191,087...106,194,529
Ensembl chr11:106,191,097...106,192,691
JBrowse link
G Igf1r insulin-like growth factor I receptor decreases expression ISO sirtinol results in decreased expression of IGF1R mRNA CTD PMID:22495798 NCBI chr 7:67,601,486...67,883,416
Ensembl chr 7:67,602,575...67,883,416
JBrowse link
G Igfbp3 insulin-like growth factor binding protein 3 increases expression ISO sirtinol results in increased expression of IGFBP3 mRNA CTD PMID:22495798 NCBI chr11:7,156,086...7,165,498
Ensembl chr11:7,156,086...7,163,923
JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases expression
ISO
EXP
sirtinol inhibits the reaction [resveratrol inhibits the reaction [IL1B protein results in increased expression of CCL2 mRNA]]
sirtinol inhibits the reaction [resveratrol inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]]
sirtinol results in increased expression of IL1B mRNA
CTD PMID:20531350 PMID:22385246 PMID:23973301 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059
JBrowse link
G Klf2 Kruppel-like transcription factor 2 (lung) multiple interactions ISO sirtinol inhibits the reaction [resveratrol results in increased expression of KLF2 mRNA] CTD PMID:19815564 NCBI chr 8:73,072,906...73,075,498
Ensembl chr 8:73,072,877...73,075,500
JBrowse link
G Mapk1 mitogen-activated protein kinase 1 decreases phosphorylation ISO sirtinol results in decreased phosphorylation of MAPK1 protein CTD PMID:21745208 NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317
JBrowse link
G Mapk3 mitogen-activated protein kinase 3 decreases phosphorylation ISO sirtinol results in decreased phosphorylation of MAPK3 protein CTD PMID:21745208 NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991
JBrowse link
G Mir141 microRNA 141 multiple interactions ISO sirtinol affects the reaction [MIR141 mRNA affects the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of NOS1 protein]]; sirtinol affects the reaction [MIR141 mRNA affects the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of SNCA protein]] CTD PMID:33204711 NCBI chr 6:124,694,877...124,694,948
Ensembl chr 6:124,694,877...124,694,948
JBrowse link
G Myc myelocytomatosis oncogene multiple interactions ISO sirtinol inhibits the reaction [resveratrol results in decreased expression of MYC protein] CTD PMID:24395567 NCBI chr15:61,857,190...61,862,210
Ensembl chr15:61,857,240...61,862,223
JBrowse link
G Nanog Nanog homeobox multiple interactions ISO sirtinol inhibits the reaction [cordycepin results in increased expression of NANOG mRNA] CTD PMID:36881089 NCBI chr 6:122,684,448...122,691,592
Ensembl chr 6:122,684,448...122,691,592
JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 multiple interactions ISO sirtinol inhibits the reaction [resveratrol results in increased expression of NFE2L2 protein] CTD PMID:24395567 NCBI chr 2:75,505,860...75,535,007
Ensembl chr 2:75,505,857...75,534,985
JBrowse link
G Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha increases degradation ISO sirtinol results in increased degradation of NFKBIA protein CTD PMID:21745208 NCBI chr12:55,536,194...55,539,432
Ensembl chr12:55,536,195...55,539,432
JBrowse link
G Nkx3-1 NK3 homeobox 1 decreases expression ISO sirtinol results in decreased expression of NKX3-1 mRNA CTD PMID:22495798 NCBI chr14:69,428,141...69,432,107
Ensembl chr14:69,428,087...69,432,111
JBrowse link
G Nos1 nitric oxide synthase 1, neuronal multiple interactions ISO sirtinol affects the reaction [MIR141 mRNA affects the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of NOS1 protein]] CTD PMID:33204711 NCBI chr 5:118,004,904...118,096,905
Ensembl chr 5:117,919,097...118,096,905
JBrowse link
G Nox4 NADPH oxidase 4 multiple interactions
increases expression
ISO resveratrol inhibits the reaction [sirtinol results in increased expression of NOX4 mRNA] CTD PMID:23422569 NCBI chr 7:86,893,638...87,047,918
Ensembl chr 7:86,895,304...87,047,918
JBrowse link
G Nqo1 NAD(P)H dehydrogenase, quinone 1 multiple interactions
increases expression
ISO AHR mutant form inhibits the reaction [sirtinol results in increased expression of NQO1 mRNA] CTD PMID:22495798 NCBI chr 8:108,114,856...108,139,012
Ensembl chr 8:108,114,857...108,129,838
JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 multiple interactions ISO sirtinol inhibits the reaction [resveratrol results in increased expression of NR0B2 mRNA] CTD PMID:26044878 NCBI chr 4:133,280,687...133,283,997
Ensembl chr 4:133,280,687...133,283,847
JBrowse link
G Pdk1 pyruvate dehydrogenase kinase, isoenzyme 1 multiple interactions ISO sirtinol inhibits the reaction [resveratrol results in decreased expression of PDK1 protein] CTD PMID:24395567 NCBI chr 2:71,703,398...71,734,202
Ensembl chr 2:71,703,568...71,734,202
JBrowse link
G Pdk4 pyruvate dehydrogenase kinase, isoenzyme 4 multiple interactions EXP sirtinol inhibits the reaction [resveratrol inhibits the reaction [Doxorubicin results in increased expression of PDK4 protein]] CTD PMID:26450947 NCBI chr 6:5,483,351...5,496,278
Ensembl chr 6:5,483,351...5,496,309
JBrowse link
G Pdpk1 3-phosphoinositide dependent protein kinase 1 multiple interactions EXP sirtinol inhibits the reaction [resveratrol inhibits the reaction [Doxorubicin results in decreased expression of PDPK1 protein]] CTD PMID:26450947 NCBI chr17:24,292,654...24,370,957
Ensembl chr17:24,292,654...24,369,898
JBrowse link
G Pou5f1 POU domain, class 5, transcription factor 1 multiple interactions ISO sirtinol inhibits the reaction [cordycepin results in increased expression of POU5F1 mRNA] CTD PMID:36881089 NCBI chr17:35,816,929...35,821,674
Ensembl chr17:35,816,915...35,821,669
JBrowse link
G Ppargc1a peroxisome proliferative activated receptor, gamma, coactivator 1 alpha multiple interactions ISO
EXP
sirtinol inhibits the reaction [Melatonin inhibits the reaction [Cadmium Chloride results in increased acetylation of PPARGC1A protein]]; sirtinol inhibits the reaction [Melatonin inhibits the reaction [Cadmium results in increased acetylation of PPARGC1A protein]]
sirtinol inhibits the reaction [genipin inhibits the reaction [[Blood Glucose deficiency co-treated with Oxygen deficiency] results in decreased expression of PPARGC1A protein]]
sirtinol inhibits the reaction [resveratrol results in increased expression of PPARGC1A protein]
CTD PMID:24395567 PMID:25159133 PMID:28477916 NCBI chr 5:51,611,591...52,273,316
Ensembl chr 5:51,611,592...51,725,068
JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase multiple interactions EXP sirtinol inhibits the reaction [genipin inhibits the reaction [[Blood Glucose deficiency co-treated with Oxygen deficiency] results in decreased expression of PRKN protein]] CTD PMID:28477916 NCBI chr17:11,059,227...12,282,257
Ensembl chr17:11,059,271...12,282,248
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO sirtinol inhibits the reaction [resveratrol inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]] CTD PMID:23257246 NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978
JBrowse link
G Rb1 RB transcriptional corepressor 1 multiple interactions ISO sirtinol promotes the reaction [cudraflavone B results in decreased phosphorylation of RB1 protein] CTD PMID:23881456 NCBI chr14:73,430,298...73,563,446
Ensembl chr14:73,421,113...73,563,262
JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) multiple interactions
increases localization
ISO
EXP
sirtinol inhibits the reaction [resveratrol inhibits the reaction [TNF protein results in increased acetylation of RELA protein]]
sirtinol promotes the reaction [TNF protein results in increased acetylation of RELA protein]
sirtinol results in increased localization of RELA protein
CTD PMID:21745208 PMID:22717288 PMID:23257246 NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158
JBrowse link
G Shc1 src homology 2 domain-containing transforming protein C1 multiple interactions
increases expression
ISO sirtinol inhibits the reaction [SIRT1 protein binds to SHC1 promoter]
sirtinol results in increased expression of SHC1 mRNA; sirtinol results in increased expression of SHC1 protein
CTD PMID:21778425 NCBI chr 3:89,325,858...89,337,336
Ensembl chr 3:89,325,750...89,337,334
JBrowse link
G Sirt1 sirtuin 1 decreases activity
multiple interactions
ISO
EXP
sirtinol analog results in decreased activity of SIRT1 protein; sirtinol results in decreased activity of SIRT1 protein
sirtinol inhibits the reaction [cobaltous chloride results in increased expression of SIRT1 protein]; sirtinol inhibits the reaction [Resveratrol results in increased expression of and results in increased activity of SIRT1 protein]
[sirtinol results in decreased activity of SIRT1 protein] which results in decreased susceptibility to Glucose; sirtinol inhibits the reaction [Cilostazol inhibits the reaction [APP protein results in decreased expression of and results in decreased activity of SIRT1 protein]]; sirtinol inhibits the reaction [Cilostazol results in increased phosphorylation of SIRT1 protein]; sirtinol inhibits the reaction [genipin inhibits the reaction [[Blood Glucose deficiency co-treated with Oxygen deficiency] results in decreased expression of SIRT1 protein]]; sirtinol inhibits the reaction [Resveratrol inhibits the reaction [Doxorubicin results in decreased activity of SIRT1 protein]]; sirtinol inhibits the reaction [Resveratrol inhibits the reaction [Lipopolysaccharides results in decreased expression of SIRT1 protein]]
[sirtinol results in decreased activity of SIRT1 protein] promotes the reaction [Hydrogen Peroxide results in increased acetylation of TP53 protein]; [sirtinol results in decreased activity of SIRT1 protein] which results in decreased expression of FBXO32 mRNA; [sirtinol results in decreased activity of SIRT1 protein] which results in decreased susceptibility to Plant Extracts; [sirtinol results in decreased activity of SIRT1 protein] which results in decreased susceptibility to Resveratrol; [sirtinol results in decreased activity of SIRT1 protein] which results in increased susceptibility to Hydrogen Peroxide; sirtinol inhibits the reaction [[Resveratrol co-treated with TNF protein] results in increased expression of SIRT1 protein]; sirtinol inhibits the reaction [cordycepin results in increased expression of SIRT1 mRNA]; sirtinol inhibits the reaction [cudraflavone B results in increased expression of SIRT1 mRNA]; sirtinol inhibits the reaction [cudraflavone B results in increased expression of SIRT1 protein]; sirtinol inhibits the reaction [Melatonin inhibits the reaction [Cadmium Chloride results in decreased expression of and results in decreased activity of SIRT1 protein]]; sirtinol inhibits the reaction [Melatonin inhibits the reaction [Cadmium results in decreased expression of and results in decreased activity of SIRT1 protein]]; sirtinol inhibits the reaction [SIRT1 protein binds to SHC1 promoter]
CTD PMID:16302818 PMID:18681908 PMID:19288225 PMID:20370652 PMID:20531350 More... NCBI chr10:63,154,784...63,174,814
Ensembl chr10:63,154,784...63,217,483
JBrowse link
G Sirt2 sirtuin 2 decreases activity ISO sirtinol analog results in decreased activity of SIRT2 protein; sirtinol results in decreased activity of SIRT2 protein CTD PMID:16302818 PMID:24998427 NCBI chr 7:28,466,192...28,488,086
Ensembl chr 7:28,466,160...28,488,086
JBrowse link
G Smad1 SMAD family member 1 decreases phosphorylation ISO sirtinol results in decreased phosphorylation of SMAD1 protein CTD PMID:21745208 NCBI chr 8:80,065,024...80,126,057
Ensembl chr 8:80,065,024...80,126,147
JBrowse link
G Smad5 SMAD family member 5 decreases phosphorylation ISO sirtinol results in decreased phosphorylation of SMAD5 protein CTD PMID:21745208 NCBI chr13:56,850,804...56,890,191
Ensembl chr13:56,850,823...56,890,190
JBrowse link
G Smad9 SMAD family member 9 decreases phosphorylation ISO sirtinol results in decreased phosphorylation of SMAD9 protein CTD PMID:21745208 NCBI chr 3:54,662,873...54,709,162
Ensembl chr 3:54,663,003...54,708,678
JBrowse link
G Snca synuclein, alpha multiple interactions ISO sirtinol affects the reaction [MIR141 mRNA affects the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of SNCA protein]] CTD PMID:33204711 NCBI chr 6:60,708,557...60,806,839
Ensembl chr 6:60,708,559...60,806,839
JBrowse link
G Sox2 SRY (sex determining region Y)-box 2 multiple interactions ISO sirtinol inhibits the reaction [cordycepin results in increased expression of SOX2 mRNA] CTD PMID:36881089 NCBI chr 3:34,704,144...34,706,610
Ensembl chr 3:34,704,554...34,706,610
JBrowse link
G Sqstm1 sequestosome 1 multiple interactions ISO sirtinol inhibits the reaction [resveratrol inhibits the reaction [Hydrogen Peroxide results in increased expression of SQSTM1 protein]]; sirtinol promotes the reaction [Hydrogen Peroxide results in increased expression of SQSTM1 protein] CTD PMID:24889822 NCBI chr11:50,090,979...50,105,303
Ensembl chr11:50,090,193...50,101,654
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions ISO sirtinol inhibits the reaction [S-allylcysteine results in decreased expression of SREBF1 protein] CTD PMID:23465592 NCBI chr11:60,089,910...60,113,407
Ensembl chr11:60,089,915...60,113,407
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression
ISO
EXP
sirtinol inhibits the reaction [[resveratrol co-treated with TNF protein] results in increased expression of SIRT1 protein]; sirtinol inhibits the reaction [resveratrol inhibits the reaction [TNF protein results in increased acetylation of RELA protein]]; sirtinol inhibits the reaction [resveratrol inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]]; sirtinol promotes the reaction [TNF protein results in increased expression of F3 mRNA]; sirtinol promotes the reaction [TNF protein results in increased expression of F3 protein]
Sirtinol promotes the reactions [Lipopolysaccharide, acetate, acetaldehyde increases secretion of Tnf protein from Kupffer cells]
sirtinol inhibits the reaction [Resveratrol inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]]; sirtinol promotes the reaction [TNF protein results in increased acetylation of RELA protein]; sirtinol promotes the reaction [TNF protein results in increased expression of CD40 mRNA]
sirtinol results in increased expression of TNF mRNA
CTD
RGD
PMID:20978007 PMID:22385246 PMID:22717288 PMID:23257246 PMID:23973301 More... RGD:9585771 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983
JBrowse link
G Trim63 tripartite motif-containing 63 multiple interactions EXP sirtinol inhibits the reaction [resveratrol inhibits the reaction [Doxorubicin results in increased expression of TRIM63 protein]] CTD PMID:25665036 PMID:26450947 NCBI chr 4:134,042,431...134,056,940
Ensembl chr 4:134,042,431...134,056,940
JBrowse link
G Trp53 transformation related protein 53 multiple interactions ISO
EXP
[sirtinol results in decreased activity of SIRT1 protein] promotes the reaction [Hydrogen Peroxide results in increased acetylation of TP53 protein]; sirtinol promotes the reaction [arsenic disulfide results in increased expression of and results in increased phosphorylation of TP53 protein]; sirtinol promotes the reaction [cudraflavone B results in increased expression of TP53 protein]
sirtinol inhibits the reaction [resveratrol inhibits the reaction [Doxorubicin results in increased expression of TRP53 protein]]
CTD PMID:18298901 PMID:18681908 PMID:23881456 PMID:25665036 NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699
JBrowse link
G Usp7 ubiquitin specific peptidase 7 multiple interactions EXP sirtinol inhibits the reaction [resveratrol inhibits the reaction [Doxorubicin results in increased expression of USP7 protein]] CTD PMID:25665036 NCBI chr16:8,506,586...8,574,931
Ensembl chr16:8,507,459...8,610,172
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO [sirtinol co-treated with cobaltous chloride] results in increased cleavage of VEGFA protein; sirtinol inhibits the reaction [cobaltous chloride results in increased secretion of VEGFA protein] CTD PMID:22669716 NCBI chr17:46,327,919...46,343,303
Ensembl chr17:46,327,919...46,343,295
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 22157
    chemical entity 22207
      atom 22149
        nonmetal atom 22033
          carbon atom 21858
            organic molecular entity 21858
              imine 193
                1-pyrroline 0
                2,6-dichlorophenol-4-(2,3-dihydro-1,4-naphthoquinone imine) 0
                2-\{5-amino-4-[cyano(imino)methyl]-1H-imidazol-1-yl\}-3-phenylpropanoic acid 0
                2-chloro-3-(3-methoxypropylimino)naphthalene-1,4-dione 0
                2-chloro-3-propan-2-yliminonaphthalene-1,4-dione 0
                2-hydroxy-5-[(1E)-(2-phenylethylidene)amino]-L-tyrosine 0
                2-methyl-1-pyrroline 0
                3,4-dihydroxy-5-(2-hydroxyethanimidoyl)oxolan-2-one 0
                3-methyl-4-[(4'-methyl[2,2'-bipyridin]-4-yl)imino]but-2-en-2-amine 0
                Hoffman's violet free base 0
                Methyl violet 2B free base 0
                N-[(E)-4-aminobutylidene]propane-1,3-diamine 0
                N-[(E)-\{[(Z)-2-amino-1,2-dicyanoethenyl]imino\}methyl]phenylalanine 0
                N-[3-(2-methoxyphenyl)imino-1,4-dioxo-2-naphthalenyl]acetamide 0
                SRS16-86 0
                Schiff base + 0
                acid fuchsin (free acid form) 0
                acridine red 3B free base 0
                acylimine + 0
                aldimine + 65
                alkali Blue G 0
                auramine O free base 0
                azaxylylene + 0
                azocarmine B free acid 0
                azocarmine G free acid 0
                clitidine 0
                dehydroglycine 0
                iminopiperidine + 0
                ketenimine 0
                ketimine + 72
                magenta II free base 0
                methyl blue free acid 0
                new fuchsin free base 0
                nitrone + 3
                pararosaniline free base 3
                pyrimidinimine + 0
                quinone imine + 133
                rosanilin free base 0
                spirit blue base 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 22157
    subatomic particle 22149
      composite particle 22149
        hadron 22200
          baryon 22200
            nucleon 22200
              atomic nucleus 22200
                atom 22149
                  main group element atom 22134
                    p-block element atom 22134
                      p-block molecular entity 22134
                        carbon group molecular entity 21933
                          organic molecular entity 21858
                            heteroorganic entity 21511
                              organonitrogen compound 19834
                                imine 193
                                  1-pyrroline 0
                                  2,6-dichlorophenol-4-(2,3-dihydro-1,4-naphthoquinone imine) 0
                                  2-\{5-amino-4-[cyano(imino)methyl]-1H-imidazol-1-yl\}-3-phenylpropanoic acid 0
                                  2-chloro-3-(3-methoxypropylimino)naphthalene-1,4-dione 0
                                  2-chloro-3-propan-2-yliminonaphthalene-1,4-dione 0
                                  2-hydroxy-5-[(1E)-(2-phenylethylidene)amino]-L-tyrosine 0
                                  2-methyl-1-pyrroline 0
                                  3,4-dihydroxy-5-(2-hydroxyethanimidoyl)oxolan-2-one 0
                                  3-methyl-4-[(4'-methyl[2,2'-bipyridin]-4-yl)imino]but-2-en-2-amine 0
                                  Hoffman's violet free base 0
                                  Methyl violet 2B free base 0
                                  N-[(E)-4-aminobutylidene]propane-1,3-diamine 0
                                  N-[(E)-\{[(Z)-2-amino-1,2-dicyanoethenyl]imino\}methyl]phenylalanine 0
                                  N-[3-(2-methoxyphenyl)imino-1,4-dioxo-2-naphthalenyl]acetamide 0
                                  SRS16-86 0
                                  Schiff base + 0
                                  acid fuchsin (free acid form) 0
                                  acridine red 3B free base 0
                                  acylimine + 0
                                  aldimine + 65
                                  alkali Blue G 0
                                  auramine O free base 0
                                  azaxylylene + 0
                                  azocarmine B free acid 0
                                  azocarmine G free acid 0
                                  clitidine 0
                                  dehydroglycine 0
                                  iminopiperidine + 0
                                  ketenimine 0
                                  ketimine + 72
                                  magenta II free base 0
                                  methyl blue free acid 0
                                  new fuchsin free base 0
                                  nitrone + 3
                                  pararosaniline free base 3
                                  pyrimidinimine + 0
                                  quinone imine + 133
                                  rosanilin free base 0
                                  spirit blue base 0
paths to the root