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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:imine
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Accession:CHEBI:24783 term browser browse the term
Definition:Compounds having the structure RN=CR2 (R = H, hydrocarbyl). Thus analogues of aldehydes or ketones, having NR doubly bonded to carbon; aldimines have the structure RCH=NR, ketimines have the structure R'2C=NR (where R' is not H). Imines include azomethines and Schiff bases. Imine is used as a suffix in systematic nomenclature to denote the C=NH group excluding the carbon atom.
Synonyms:related_synonym: Formula=CNR3;   SMILES=[*]\\C([*])=N\\[*];   imines


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2,6-dichloroindophenol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BCL2L1 BCL2 like 1 multiple interactions EXP [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in decreased expression of BCL2L1 mRNA CTD PMID:21034357 NCBI chr20:31,664,452...31,723,963
Ensembl chr20:31,664,452...31,723,989
JBrowse link
G CCL4 C-C motif chemokine ligand 4 multiple interactions EXP [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of CCL4 mRNA CTD PMID:21034357 NCBI chr17:36,103,827...36,105,614
Ensembl chr17:36,103,827...36,105,621
JBrowse link
G CDKN1A cyclin dependent kinase inhibitor 1A multiple interactions EXP [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of CDKN1A mRNA; [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of CDKN1A protein CTD PMID:21034357 NCBI chr 6:36,676,463...36,687,332
Ensembl chr 6:36,676,460...36,687,337
JBrowse link
G CNTF ciliary neurotrophic factor multiple interactions EXP 2,6-Dichloroindophenol inhibits the reaction [Cadmium Chloride inhibits the reaction [CNTF results in increased phosphorylation of STAT1 protein]]; 2,6-Dichloroindophenol inhibits the reaction [Cadmium Chloride inhibits the reaction [CNTF results in increased phosphorylation of STAT3 protein]] CTD PMID:19635391 NCBI chr11:58,622,665...58,625,733
Ensembl chr11:58,622,665...58,625,733
JBrowse link
G CRYAB crystallin alpha B multiple interactions EXP [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of CRYAB mRNA CTD PMID:21034357 NCBI chr11:111,908,564...111,923,740
Ensembl chr11:111,908,564...111,923,722
JBrowse link
G CXCL10 C-X-C motif chemokine ligand 10 multiple interactions EXP [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of CXCL10 mRNA CTD PMID:21034357 NCBI chr 4:76,021,118...76,023,497
Ensembl chr 4:76,021,118...76,023,497
JBrowse link
G EGR1 early growth response 1 multiple interactions EXP [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of EGR1 mRNA CTD PMID:21034357 NCBI chr 5:138,465,479...138,469,303
Ensembl chr 5:138,465,479...138,469,303
JBrowse link
G EPHX2 epoxide hydrolase 2 multiple interactions EXP [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of EPHX2 mRNA CTD PMID:21034357 NCBI chr 8:27,491,143...27,597,559
Ensembl chr 8:27,490,781...27,545,564
JBrowse link
G FASLG Fas ligand multiple interactions EXP [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of FASLG mRNA CTD PMID:21034357 NCBI chr 1:172,659,103...172,666,876
Ensembl chr 1:172,659,103...172,666,876
JBrowse link
G GADD45A growth arrest and DNA damage inducible alpha multiple interactions EXP [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of GADD45A mRNA CTD PMID:21034357 NCBI chr 1:67,685,201...67,688,334
Ensembl chr 1:67,685,201...67,688,334
JBrowse link
G GDF15 growth differentiation factor 15 multiple interactions EXP [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of GDF15 mRNA CTD PMID:21034357 NCBI chr19:18,382,170...18,389,176
Ensembl chr19:18,374,731...18,389,176
JBrowse link
G GSTM3 glutathione S-transferase mu 3 multiple interactions EXP [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of GSTM3 mRNA CTD PMID:21034357 NCBI chr 1:109,733,937...109,741,038
Ensembl chr 1:109,733,932...109,741,038
JBrowse link
G HMOX1 heme oxygenase 1 multiple interactions EXP [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of HMOX1 mRNA; [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of HMOX1 protein CTD PMID:21034357 NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,214
JBrowse link
G HSPA1A heat shock protein family A (Hsp70) member 1A multiple interactions EXP [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of HSPA1A mRNA; [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of HSPA1A protein CTD PMID:21034357 NCBI chr 6:31,815,543...31,817,942
Ensembl chr 6:31,815,543...31,817,946
JBrowse link
G HSPA2 heat shock protein family A (Hsp70) member 2 multiple interactions EXP [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of HSPA2 mRNA CTD PMID:21034357 NCBI chr14:64,535,905...64,543,237
Ensembl chr14:64,535,905...64,546,173
JBrowse link
G HSPA6 heat shock protein family A (Hsp70) member 6 multiple interactions EXP [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of HSPA6 mRNA; [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of HSPA6 protein CTD PMID:21034357 NCBI chr 1:161,524,540...161,526,894
Ensembl chr 1:161,524,540...161,526,894
JBrowse link
G LTA lymphotoxin alpha multiple interactions EXP [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of LTA mRNA CTD PMID:21034357 NCBI chr 6:31,560,550...31,574,324
Ensembl chr 6:31,572,054...31,574,324
JBrowse link
G NOS2 nitric oxide synthase 2 multiple interactions EXP [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of NOS2 mRNA CTD PMID:21034357 NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529
JBrowse link
G NQO1 NAD(P)H quinone dehydrogenase 1 multiple interactions
increases reduction
increases response to substance
EXP [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in decreased expression of BCL2L1 mRNA; [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of CCL4 mRNA; [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of CDKN1A mRNA; [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of CDKN1A protein; [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of CRYAB mRNA; [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of CXCL10 mRNA; [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of EGR1 mRNA; [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of EPHX2 mRNA; [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of FASLG mRNA; [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of GADD45A mRNA; [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of GDF15 mRNA; [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of GSTM3 mRNA; [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of HMOX1 mRNA; [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of HMOX1 protein; [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of HSPA1A mRNA; [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of HSPA1A protein; [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of HSPA2 mRNA; [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of HSPA6 mRNA; [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of HSPA6 protein; [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of LTA mRNA; [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of NOS2 mRNA; [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of TNF mRNA; [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased phosphorylation of TP53 protein; Carbamazepine inhibits the reaction [NQO1 protein results in increased reduction of 2,6-Dichloroindophenol]; Diclofenac inhibits the reaction [NQO1 protein results in increased reduction of 2,6-Dichloroindophenol]; Dicumarol inhibits the reaction [NQO1 protein results in increased reduction of 2,6-Dichloroindophenol]; Mefenamic Acid inhibits the reaction [NQO1 protein results in increased reduction of 2,6-Dichloroindophenol]; NQO1 protein inhibits the reaction [2,6-Dichloroindophenol results in decreased abundance of Glutathione]; NQO1 protein polymorphism promotes the reaction [2,6-Dichloroindophenol results in decreased abundance of Glutathione]; Tacrine inhibits the reaction [NQO1 protein results in increased reduction of 2,6-Dichloroindophenol]
NQO1 protein polymorphism results in increased susceptibility to 2,6-Dichloroindophenol
CTD PMID:21034357 PMID:29281794 NCBI chr16:69,709,401...69,726,560
Ensembl chr16:69,706,996...69,726,668
JBrowse link
G NQO2 N-ribosyldihydronicotinamide:quinone reductase 2 multiple interactions
increases reduction
EXP [NQO2 protein results in increased oxidation of 1-benzyl-1,4-dihydronicotinamide] which results in increased reduction of 2,6-Dichloroindophenol; [NQO2 protein results in increased oxidation of nicotinamide-beta-riboside] which results in increased reduction of 2,6-Dichloroindophenol; resveratrol inhibits the reaction [NQO2 protein results in increased reduction of 2,6-Dichloroindophenol]; Tacrine inhibits the reaction [NQO2 protein results in increased reduction of 2,6-Dichloroindophenol] CTD PMID:20399199 PMID:29281794 NCBI chr 6:2,999,894...3,019,755
Ensembl chr 6:2,987,987...3,019,755
JBrowse link
G STAT1 signal transducer and activator of transcription 1 multiple interactions EXP 2,6-Dichloroindophenol inhibits the reaction [Cadmium Chloride inhibits the reaction [CNTF results in increased phosphorylation of STAT1 protein]] CTD PMID:19635391 NCBI chr 2:190,968,989...191,014,197
Ensembl chr 2:190,908,460...191,020,960
JBrowse link
G STAT3 signal transducer and activator of transcription 3 multiple interactions EXP 2,6-Dichloroindophenol inhibits the reaction [Cadmium Chloride inhibits the reaction [CNTF results in increased phosphorylation of STAT3 protein]] CTD PMID:19635391 NCBI chr17:42,313,324...42,388,502
Ensembl chr17:42,313,324...42,388,540
JBrowse link
G TNF tumor necrosis factor multiple interactions EXP [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of TNF mRNA CTD PMID:21034357 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
JBrowse link
G TP53 tumor protein p53 multiple interactions EXP [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased phosphorylation of TP53 protein CTD PMID:21034357 NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,538
JBrowse link
5,5-dimethyl-1-pyrroline N-oxide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALB albumin multiple interactions EXP [NOS1 co-treated with sodium sulfite co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased oxidation of ALB protein CTD PMID:20348042 NCBI chr 4:73,404,287...73,421,482
Ensembl chr 4:73,397,114...73,421,482
JBrowse link
G MPO myeloperoxidase multiple interactions EXP 4'-hydroxydiclofenac promotes the reaction [[Hydrogen Peroxide co-treated with MPO protein co-treated with Glutathione] results in increased glutathionylation of 5,5-dimethyl-1-pyrroline-1-oxide]; [[Hydrogen Peroxide results in increased activity of MPO protein] which results in increased oxidation of Glutathione] which results in increased glutathionylation of 5,5-dimethyl-1-pyrroline-1-oxide; [[MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 2,4-dichloroaniline] which results in increased expression of MPO protein modified form; [[MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 2,4-xylidine] which results in increased expression of MPO protein modified form; [[MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 2,6-xylidine] which results in increased expression of MPO protein modified form; [[MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 2-anisidine] which results in increased expression of MPO protein modified form; [[MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 2-chloroaniline] which results in increased expression of MPO protein modified form; [[MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 2-toluidine] which results in increased expression of MPO protein modified form; [[MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 3,4-dichloroaniline] which results in increased expression of MPO protein modified form; [[MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 3,4-xylidine] which results in increased expression of MPO protein modified form; [[MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 3-anisidine] which results in increased expression of MPO protein modified form; [[MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 3-chloroaniline] which results in increased expression of MPO protein modified form; [[MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 3-toluidine] which results in increased expression of MPO protein modified form; [[MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 4-aminobenzonitrile] which results in increased expression of MPO protein modified form; [[MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 4-chloroaniline] which results in increased expression of MPO protein modified form; [[MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 4-ethylaniline] which results in increased expression of MPO protein modified form; [[MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 4-fluoroaniline] which results in increased expression of MPO protein modified form; [[MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 4-nitroaniline] which results in increased expression of MPO protein modified form; [[MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 4-toluidine] which results in increased expression of MPO protein modified form; [[MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of Aminoglutethimide] which results in increased expression of MPO protein modified form; [[MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of aniline] which results in increased expression of MPO protein modified form; [[MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of Procainamide] which results in increased expression of MPO protein modified form; [Hydrogen Peroxide co-treated with MPO protein co-treated with Glutathione] results in increased glutathionylation of 5,5-dimethyl-1-pyrroline-1-oxide; [MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 2,4-dichloroaniline; [MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 2,4-xylidine; [MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 2,6-xylidine; [MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 2-anisidine; [MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 2-chloroaniline; [MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 2-toluidine; [MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 3,4-dichloroaniline; [MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 3,4-xylidine; [MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 3-anisidine; [MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 3-chloroaniline; [MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 3-toluidine; [MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 4-aminobenzonitrile; [MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 4-chloroaniline; [MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 4-ethylaniline; [MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 4-fluoroaniline; [MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 4-nitroaniline; [MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 4-toluidine; [MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of Aminoglutethimide; [MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of aniline; [MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of Procainamide; desmethylnaproxen promotes the reaction [[Hydrogen Peroxide co-treated with MPO protein co-treated with Glutathione] results in increased glutathionylation of 5,5-dimethyl-1-pyrroline-1-oxide] CTD PMID:20199096 PMID:28754375 NCBI chr17:58,269,855...58,280,935
Ensembl chr17:58,269,855...58,280,935
JBrowse link
G NOS1 nitric oxide synthase 1 multiple interactions EXP [NOS1 co-treated with sodium sulfite co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased oxidation of ALB protein CTD PMID:20348042 NCBI chr12:117,208,142...117,361,626
Ensembl chr12:117,208,142...117,452,170
JBrowse link
Bandrowski's base term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKR1B1 aldo-keto reductase family 1 member B increases expression EXP Bandrowski's base results in increased expression of AKR1B1 mRNA CTD PMID:20566472 NCBI chr 7:134,442,350...134,459,239
Ensembl chr 7:134,442,356...134,459,284
JBrowse link
G AKR1B10 aldo-keto reductase family 1 member B10 increases expression EXP Bandrowski's base results in increased expression of AKR1B10 mRNA CTD PMID:20566472 NCBI chr 7:134,527,567...134,541,412
Ensembl chr 7:134,527,567...134,541,412
JBrowse link
G AKR1C1 aldo-keto reductase family 1 member C1 increases expression EXP Bandrowski's base results in increased expression of AKR1C1 mRNA CTD PMID:20566472 NCBI chr10:4,963,415...4,983,283
Ensembl chr10:4,963,253...4,983,283
JBrowse link
G AKR1C3 aldo-keto reductase family 1 member C3 increases expression EXP Bandrowski's base results in increased expression of AKR1C3 mRNA CTD PMID:20566472 NCBI chr10:5,048,781...5,107,686
Ensembl chr10:5,035,354...5,107,686
JBrowse link
G CAT catalase increases expression EXP Bandrowski's base results in increased expression of CAT mRNA CTD PMID:20566472 NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060
JBrowse link
G CCL17 C-C motif chemokine ligand 17 affects expression EXP Bandrowski's base affects the expression of CCL17 mRNA CTD PMID:18202158 NCBI chr16:57,396,076...57,416,063
Ensembl chr16:57,404,767...57,416,063
JBrowse link
G CCL22 C-C motif chemokine ligand 22 affects expression EXP Bandrowski's base affects the expression of CCL22 mRNA CTD PMID:18202158 NCBI chr16:57,358,783...57,366,189
Ensembl chr16:57,358,783...57,366,189
JBrowse link
G CCL4 C-C motif chemokine ligand 4 affects expression EXP Bandrowski's base affects the expression of CCL4 mRNA CTD PMID:18202158 NCBI chr17:36,103,827...36,105,614
Ensembl chr17:36,103,827...36,105,621
JBrowse link
G CCR7 C-C motif chemokine receptor 7 affects expression
increases expression
EXP Bandrowski's base affects the expression of CCR7 mRNA
Bandrowski's base results in increased expression of CCR7 protein
CTD PMID:18202158 PMID:19665512 NCBI chr17:40,553,769...40,565,472
Ensembl chr17:40,553,769...40,565,472
JBrowse link
G CD80 CD80 molecule increases expression EXP Bandrowski's base results in increased expression of CD80 protein CTD PMID:31958493 NCBI chr 3:119,524,293...119,559,614
Ensembl chr 3:119,524,293...119,559,614
JBrowse link
G CD86 CD86 molecule affects expression
increases expression
EXP Bandrowski's base affects the expression of CD86 mRNA
Bandrowski's base results in increased expression of CD86 protein
CTD PMID:18202158 PMID:19665512 PMID:21742781 PMID:31958493 NCBI chr 3:122,055,362...122,121,136
Ensembl chr 3:122,055,362...122,121,139
JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 affects expression EXP Bandrowski's base affects the expression of CXCL8 mRNA CTD PMID:18202158 NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,541...73,743,716
JBrowse link
G CXCR4 C-X-C motif chemokine receptor 4 affects expression EXP Bandrowski's base affects the expression of CXCR4 mRNA CTD PMID:18202158 NCBI chr 2:136,114,349...136,118,149
Ensembl chr 2:136,114,349...136,118,149
JBrowse link
G FECH ferrochelatase increases expression EXP Bandrowski's base results in increased expression of FECH mRNA CTD PMID:20566472 NCBI chr18:57,544,377...57,586,708
Ensembl chr18:57,544,377...57,586,732
JBrowse link
G FTL ferritin light chain increases expression EXP Bandrowski's base results in increased expression of FTL mRNA CTD PMID:20566472 NCBI chr19:48,965,309...48,966,879
Ensembl chr19:48,965,309...48,966,879
JBrowse link
G G6PD glucose-6-phosphate dehydrogenase increases expression EXP Bandrowski's base results in increased expression of G6PD mRNA CTD PMID:20566472 NCBI chr  X:154,531,390...154,547,569
Ensembl chr  X:154,531,391...154,547,572
JBrowse link
G GCLC glutamate-cysteine ligase catalytic subunit increases expression EXP Bandrowski's base results in increased expression of GCLC mRNA CTD PMID:20566472 NCBI chr 6:53,497,341...53,545,101
Ensembl chr 6:53,497,341...53,616,970
JBrowse link
G GCLM glutamate-cysteine ligase modifier subunit increases expression EXP Bandrowski's base results in increased expression of GCLM mRNA CTD PMID:20566472 NCBI chr 1:93,885,199...93,910,370
Ensembl chr 1:93,885,199...93,909,456
JBrowse link
G GPX3 glutathione peroxidase 3 increases expression EXP Bandrowski's base results in increased expression of GPX3 mRNA CTD PMID:20566472 NCBI chr 5:151,020,591...151,028,988
Ensembl chr 5:151,020,438...151,028,992
JBrowse link
G GSR glutathione-disulfide reductase increases expression EXP Bandrowski's base results in increased expression of GSR mRNA CTD PMID:20566472 NCBI chr 8:30,678,066...30,727,846
Ensembl chr 8:30,678,066...30,727,846
JBrowse link
G HMOX1 heme oxygenase 1 increases expression EXP Bandrowski's base results in increased expression of HMOX1 mRNA CTD PMID:20566472 NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,214
JBrowse link
G ICAM1 intercellular adhesion molecule 1 increases expression
affects expression
EXP Bandrowski's base results in increased expression of ICAM1 protein
Bandrowski's base affects the expression of ICAM1 mRNA
CTD PMID:18202158 PMID:21742781 NCBI chr19:10,271,120...10,286,615
Ensembl chr19:10,271,093...10,286,615
JBrowse link
G MAFF MAF bZIP transcription factor F increases expression EXP Bandrowski's base results in increased expression of MAFF mRNA CTD PMID:20566472 NCBI chr22:38,201,994...38,216,511
Ensembl chr22:38,200,767...38,216,507
JBrowse link
G MAFG MAF bZIP transcription factor G increases expression EXP Bandrowski's base results in increased expression of MAFG mRNA CTD PMID:20566472 NCBI chr17:81,918,270...81,927,735
Ensembl chr17:81,918,270...81,927,735
JBrowse link
G MAFK MAF bZIP transcription factor K increases expression EXP Bandrowski's base results in increased expression of MAFK mRNA CTD PMID:20566472 NCBI chr 7:1,530,702...1,543,043
Ensembl chr 7:1,530,702...1,543,043
JBrowse link
G ME1 malic enzyme 1 increases expression EXP Bandrowski's base results in increased expression of ME1 mRNA CTD PMID:20566472 NCBI chr 6:83,210,402...83,431,078
Ensembl chr 6:83,210,402...83,431,051
JBrowse link
G MGST1 microsomal glutathione S-transferase 1 increases expression EXP Bandrowski's base results in increased expression of MGST1 mRNA CTD PMID:20566472 NCBI chr12:16,347,115...16,377,192
Ensembl chr12:16,347,142...16,609,259
JBrowse link
G MIR155 microRNA 155 increases expression EXP Bandrowski's base results in increased expression of MIR155 mRNA CTD PMID:32939143 NCBI chr21:25,573,980...25,574,044
Ensembl chr21:25,573,980...25,574,044
JBrowse link
G MIR21 microRNA 21 decreases expression EXP Bandrowski's base results in decreased expression of MIR21 mRNA CTD PMID:32939143 NCBI chr17:59,841,266...59,841,337
Ensembl chr17:59,841,266...59,841,337
JBrowse link
G MT1X metallothionein 1X increases expression EXP Bandrowski's base results in increased expression of MT1X mRNA CTD PMID:20566472 NCBI chr16:56,682,470...56,684,196
Ensembl chr16:56,682,470...56,684,196
JBrowse link
G NQO1 NAD(P)H quinone dehydrogenase 1 increases expression EXP Bandrowski's base results in increased expression of NQO1 mRNA CTD PMID:20566472 NCBI chr16:69,709,401...69,726,560
Ensembl chr16:69,706,996...69,726,668
JBrowse link
G PGD phosphogluconate dehydrogenase increases expression EXP Bandrowski's base results in increased expression of PGD mRNA CTD PMID:20566472 NCBI chr 1:10,399,064...10,420,511
Ensembl chr 1:10,398,592...10,420,511
JBrowse link
G PPIA peptidylprolyl isomerase A affects expression EXP Bandrowski's base affects the expression of PPIA mRNA CTD PMID:18202158 NCBI chr 7:44,795,960...44,803,117
Ensembl chr 7:44,796,680...44,824,564
JBrowse link
G PRKCB protein kinase C beta increases expression EXP Bandrowski's base results in increased expression of PRKCB protein CTD PMID:31958493 NCBI chr16:23,835,983...24,220,611
Ensembl chr16:23,835,983...24,220,611
JBrowse link
G PTGR1 prostaglandin reductase 1 increases expression EXP Bandrowski's base results in increased expression of PTGR1 mRNA CTD PMID:20566472 NCBI chr 9:111,549,722...111,599,855
Ensembl chr 9:111,549,722...111,599,893
JBrowse link
G SOD1 superoxide dismutase 1 increases expression EXP Bandrowski's base results in increased expression of SOD1 mRNA CTD PMID:20566472 NCBI chr21:31,659,693...31,668,931
Ensembl chr21:31,659,666...31,668,931
JBrowse link
G SOD2 superoxide dismutase 2 increases expression EXP Bandrowski's base results in increased expression of SOD2 mRNA CTD PMID:20566472 NCBI chr 6:159,669,069...159,762,281
Ensembl chr 6:159,669,069...159,762,529
JBrowse link
G SOD3 superoxide dismutase 3 increases expression EXP Bandrowski's base results in increased expression of SOD3 mRNA CTD PMID:20566472 NCBI chr 4:24,795,478...24,800,845
Ensembl chr 4:24,789,912...24,800,842
JBrowse link
G SRXN1 sulfiredoxin 1 increases expression EXP Bandrowski's base results in increased expression of SRXN1 mRNA CTD PMID:20566472 NCBI chr20:646,615...653,200
Ensembl chr20:646,615...653,200
JBrowse link
G TNFRSF1A TNF receptor superfamily member 1A affects expression EXP Bandrowski's base affects the expression of TNFRSF1A mRNA CTD PMID:18202158 NCBI chr12:6,328,771...6,342,076
Ensembl chr12:6,328,757...6,342,114
JBrowse link
G TXN2 thioredoxin 2 increases expression EXP Bandrowski's base results in increased expression of TXN2 mRNA CTD PMID:20566472 NCBI chr22:36,467,036...36,481,672
Ensembl chr22:36,467,046...36,481,640
JBrowse link
G TXNRD1 thioredoxin reductase 1 increases expression EXP Bandrowski's base results in increased expression of TXNRD1 mRNA CTD PMID:20566472 NCBI chr12:104,215,779...104,350,307
Ensembl chr12:104,215,779...104,350,307
JBrowse link
G TXNRD2 thioredoxin reductase 2 increases expression EXP Bandrowski's base results in increased expression of TXNRD2 mRNA CTD PMID:20566472 NCBI chr22:19,875,522...19,941,818
Ensembl chr22:19,875,517...19,941,820
JBrowse link
G UGT1A6 UDP glucuronosyltransferase family 1 member A6 increases expression EXP Bandrowski's base results in increased expression of UGT1A6 mRNA CTD PMID:20566472 NCBI chr 2:233,691,702...233,773,300
Ensembl chr 2:233,691,607...233,773,300
JBrowse link
N-acetyl-1,4-benzoquinone imine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACTA2 actin alpha 2, smooth muscle increases expression
multiple interactions
EXP N-acetyl-4-benzoquinoneimine results in increased expression of ACTA2 mRNA; N-acetyl-4-benzoquinoneimine results in increased expression of ACTA2 protein
andrographolide inhibits the reaction [N-acetyl-4-benzoquinoneimine results in increased expression of ACTA2 mRNA]; andrographolide inhibits the reaction [N-acetyl-4-benzoquinoneimine results in increased expression of ACTA2 protein]
CTD PMID:28286204 PMID:29355602 NCBI chr10:88,935,074...88,991,397
Ensembl chr10:88,935,074...88,991,339
JBrowse link
G ADARB2 adenosine deaminase RNA specific B2 (inactive) affects response to substance EXP ADARB2 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr10:1,177,313...1,737,525
Ensembl chr10:1,177,313...1,737,525
JBrowse link
G ALCAM activated leukocyte cell adhesion molecule affects response to substance EXP ALCAM gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr 3:105,366,909...105,576,900
Ensembl chr 3:105,366,909...105,576,900
JBrowse link
G ALDH1A3 aldehyde dehydrogenase 1 family member A3 affects response to substance EXP ALDH1A3 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr15:100,879,831...100,916,626
Ensembl chr15:100,877,714...100,916,626
JBrowse link
G BMP2 bone morphogenetic protein 2 increases expression EXP N-acetyl-4-benzoquinoneimine results in increased expression of BMP2 mRNA CTD PMID:28286204 NCBI chr20:6,767,686...6,780,246
Ensembl chr20:6,767,686...6,780,246
JBrowse link
G BPNT2 3'(2'), 5'-bisphosphate nucleotidase 2 affects response to substance EXP BPNT2 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr 8:56,957,931...56,993,874
Ensembl chr 8:56,957,931...56,993,867
JBrowse link
G C3orf38 chromosome 3 open reading frame 38 affects response to substance EXP C3ORF38 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr 3:88,149,959...88,157,966
Ensembl chr 3:88,149,959...88,168,729
JBrowse link
G CACNA1H calcium voltage-gated channel subunit alpha1 H affects response to substance EXP CACNA1H gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr16:1,153,106...1,221,769
Ensembl chr16:1,153,106...1,221,771
JBrowse link
G CALD1 caldesmon 1 affects response to substance EXP CALD1 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr 7:134,779,629...134,970,729
Ensembl chr 7:134,744,252...134,970,729
JBrowse link
G CCDC25 coiled-coil domain containing 25 affects response to substance EXP CCDC25 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr 8:27,733,316...27,772,640
Ensembl chr 8:27,733,316...27,772,653
JBrowse link
G CD9 CD9 molecule affects response to substance EXP CD9 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr12:6,199,946...6,238,266
Ensembl chr12:6,199,715...6,238,271
JBrowse link
G CEP44 centrosomal protein 44 affects response to substance EXP CEP44 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr 4:174,283,677...174,334,355
Ensembl chr 4:174,283,730...174,333,380
JBrowse link
G CNR1 cannabinoid receptor 1 affects response to substance EXP CNR1 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr 6:88,139,864...88,167,349
Ensembl chr 6:88,139,864...88,166,347
JBrowse link
G COL1A1 collagen type I alpha 1 chain increases expression
multiple interactions
EXP N-acetyl-4-benzoquinoneimine results in increased expression of COL1A1 mRNA
andrographolide inhibits the reaction [N-acetyl-4-benzoquinoneimine results in increased expression of COL1A1 mRNA]
CTD PMID:28286204 PMID:29355602 NCBI chr17:50,184,096...50,201,649
Ensembl chr17:50,184,101...50,201,632
JBrowse link
G COL1A2 collagen type I alpha 2 chain increases expression EXP N-acetyl-4-benzoquinoneimine results in increased expression of COL1A2 mRNA CTD PMID:28286204 NCBI chr 7:94,394,895...94,431,227
Ensembl chr 7:94,394,895...94,431,227
JBrowse link
G COL3A1 collagen type III alpha 1 chain increases expression
multiple interactions
EXP N-acetyl-4-benzoquinoneimine results in increased expression of COL3A1 mRNA
andrographolide inhibits the reaction [N-acetyl-4-benzoquinoneimine results in increased expression of COL3A1 mRNA]
CTD PMID:28286204 PMID:29355602 NCBI chr 2:188,974,373...189,012,746
Ensembl chr 2:188,974,373...189,012,746
JBrowse link
G CPA6 carboxypeptidase A6 affects response to substance EXP CPA6 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr 8:67,422,038...67,747,114
Ensembl chr 8:67,422,038...67,746,378
JBrowse link
G CST5 cystatin D affects response to substance EXP CST5 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr20:23,875,934...23,879,748
Ensembl chr20:23,875,934...23,879,748
JBrowse link
G CYP1A2 cytochrome P450 family 1 subfamily A member 2 multiple interactions
increases abundance
ISO
EXP
CYP1A2 protein results in increased chemical synthesis of and results in increased abundance of N-acetyl-4-benzoquinoneimine
CYP1A2 protein results in increased abundance of N-acetyl-4-benzoquinoneimine
CTD PMID:19679878 PMID:24661219 NCBI chr15:74,748,845...74,756,607
Ensembl chr15:74,748,845...74,756,607
JBrowse link
G CYP2D6 cytochrome P450 family 2 subfamily D member 6 increases abundance EXP CYP2D6 protein results in increased abundance of N-acetyl-4-benzoquinoneimine CTD PMID:24661219 NCBI chr22:42,126,499...42,130,810
Ensembl chr22:42,126,499...42,130,865
JBrowse link
G CYP2E1 cytochrome P450 family 2 subfamily E member 1 multiple interactions
increases abundance
increases chemical synthesis
ISO
EXP
CYP2E1 protein results in increased chemical synthesis of and results in increased abundance of N-acetyl-4-benzoquinoneimine
CYP2E1 protein results in increased abundance of N-acetyl-4-benzoquinoneimine
CYP2E1 results in increased chemical synthesis of N-acetyl-4-benzoquinoneimine
CTD PMID:19679878 PMID:20566340 PMID:24661219 NCBI chr10:133,527,363...133,539,123
Ensembl chr10:133,520,406...133,561,220
JBrowse link
G CYP3A4 cytochrome P450 family 3 subfamily A member 4 increases abundance EXP CYP3A4 protein results in increased abundance of N-acetyl-4-benzoquinoneimine CTD PMID:24661219 NCBI chr 7:99,756,967...99,784,184
Ensembl chr 7:99,756,960...99,784,248
JBrowse link
G DMRT1 doublesex and mab-3 related transcription factor 1 affects response to substance EXP DMRT1 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr 9:841,647...969,090
Ensembl chr 9:841,690...969,090
JBrowse link
G DNTTIP1 deoxynucleotidyltransferase terminal interacting protein 1 affects response to substance EXP DNTTIP1 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr20:45,791,954...45,811,419
Ensembl chr20:45,791,954...45,811,427
JBrowse link
G DSC3 desmocollin 3 affects response to substance EXP DSC3 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr18:30,989,365...31,042,742
Ensembl chr18:30,989,365...31,042,815
JBrowse link
G ETNK2 ethanolamine kinase 2 affects response to substance EXP ETNK2 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr 1:204,131,062...204,152,044
Ensembl chr 1:204,131,062...204,152,044
JBrowse link
G FBXO39 F-box protein 39 affects response to substance EXP FBXO39 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr17:6,776,215...6,787,646
Ensembl chr17:6,776,215...6,797,101
JBrowse link
G FRK fyn related Src family tyrosine kinase affects response to substance EXP FRK gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr 6:115,931,149...116,100,739
Ensembl chr 6:115,931,149...116,060,891
JBrowse link
G FTH1P5 ferritin heavy chain 1 pseudogene 5 affects response to substance EXP FTH1P5 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr 6:50,912,550...50,913,462
Ensembl chr 6:50,912,712...50,913,256
JBrowse link
G GPX1 glutathione peroxidase 1 multiple interactions
affects response to substance
ISO [GPX1 protein co-treated with SOD1 protein] affects the susceptibility to N-acetyl-4-benzoquinoneimine
GPX1 protein affects the susceptibility to N-acetyl-4-benzoquinoneimine
CTD PMID:16636302 NCBI chr 3:49,357,176...49,358,353
Ensembl chr 3:49,357,176...49,358,353
JBrowse link
G GSTP1 glutathione S-transferase pi 1 affects metabolic processing
multiple interactions
increases glutathionylation
increases metabolic processing
EXP
ISO
GSTP1 protein polymorphism affects the metabolism of N-acetyl-4-benzoquinoneimine metabolite
NQO1 protein inhibits the reaction [GSTP1 protein results in increased glutathionylation of N-acetyl-4-benzoquinoneimine]
GSTP1 protein results in increased metabolism of N-acetyl-4-benzoquinoneimine
CTD PMID:24185126 PMID:24552538 NCBI chr11:67,583,812...67,586,653
Ensembl chr11:67,583,742...67,586,656
JBrowse link
G HDAC4 histone deacetylase 4 affects response to substance EXP HDAC4 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr 2:239,048,168...239,401,649
Ensembl chr 2:239,048,168...239,401,654
JBrowse link
G HID1 HID1 domain containing affects response to substance EXP HID1 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr17:74,950,742...74,972,763
Ensembl chr17:74,950,742...74,973,166
JBrowse link
G IL23R interleukin 23 receptor affects response to substance EXP IL23R gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr 1:67,138,639...67,259,979
Ensembl chr 1:67,138,907...67,259,979
JBrowse link
G KCNJ3 potassium inwardly rectifying channel subfamily J member 3 affects response to substance EXP KCNJ3 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr 2:154,698,695...154,858,354
Ensembl chr 2:154,697,855...154,858,354
JBrowse link
G KCNU1 potassium calcium-activated channel subfamily U member 1 affects response to substance EXP KCNU1 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr 8:36,784,374...36,936,125
Ensembl chr 8:36,784,324...36,936,125
JBrowse link
G KEAP1 kelch like ECH associated protein 1 multiple interactions
affects metabolic processing
ISO KEAP1 protein inhibits the reaction [NQO1 protein results in increased metabolism of N-acetyl-4-benzoquinoneimine]
N-acetyl-4-benzoquinoneimine affects the metabolism of KEAP1 protein
CTD PMID:18785192 PMID:19246624 NCBI chr19:10,486,125...10,503,356
Ensembl chr19:10,486,125...10,503,558
JBrowse link
G LAMA4 laminin subunit alpha 4 affects response to substance EXP LAMA4 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr 6:112,107,931...112,254,722
Ensembl chr 6:112,107,931...112,254,939
JBrowse link
G LMX1A LIM homeobox transcription factor 1 alpha affects response to substance EXP LMX1A gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr 1:165,201,867...165,356,715
Ensembl chr 1:165,201,867...165,356,715
JBrowse link
G MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 affects response to substance EXP MAGI2 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr 7:78,017,055...79,453,667
Ensembl chr 7:78,017,055...79,453,667
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 increases phosphorylation EXP N-acetyl-4-benzoquinoneimine results in increased phosphorylation of MAPK1 protein CTD PMID:28286204 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 increases phosphorylation EXP N-acetyl-4-benzoquinoneimine results in increased phosphorylation of MAPK3 protein CTD PMID:28286204 NCBI chr16:30,114,105...30,123,309
Ensembl chr16:30,114,105...30,123,506
JBrowse link
G MCTP1 multiple C2 and transmembrane domain containing 1 affects response to substance EXP MCTP1 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr 5:94,703,690...95,285,094
Ensembl chr 5:94,703,741...95,284,575
JBrowse link
G MFSD4A major facilitator superfamily domain containing 4A affects response to substance EXP MFSD4A gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr 1:205,569,014...205,602,918
Ensembl chr 1:205,568,885...205,602,918
JBrowse link
G MIR135A2 microRNA 135a-2 affects response to substance EXP MIR135A2 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr12:97,563,812...97,563,911
Ensembl chr12:97,563,812...97,563,911
JBrowse link
G MMP2 matrix metallopeptidase 2 increases expression EXP N-acetyl-4-benzoquinoneimine results in increased expression of MMP2 mRNA CTD PMID:28286204 NCBI chr16:55,478,830...55,506,691
Ensembl chr16:55,389,700...55,506,691
JBrowse link
G MTUS2 microtubule associated scaffold protein 2 affects response to substance EXP MTUS2 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr13:28,819,963...29,505,947
Ensembl chr13:28,820,339...29,505,947
JBrowse link
G NEB nebulin affects response to substance EXP NEB gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr 2:151,485,334...151,734,476
Ensembl chr 2:151,485,336...151,734,487
JBrowse link
G NFE2L2 nuclear factor, erythroid 2 like 2 affects localization
multiple interactions
increases activity
ISO N-acetyl-4-benzoquinoneimine affects the localization of NFE2L2 protein
NFE2L2 protein affects the reaction [N-acetyl-4-benzoquinoneimine results in increased expression of NQO1 mRNA]; NFE2L2 protein promotes the reaction [NQO1 protein results in increased metabolism of N-acetyl-4-benzoquinoneimine]
N-acetyl-4-benzoquinoneimine results in increased activity of NFE2L2 protein
CTD PMID:18785192 PMID:19246624 NCBI chr 2:177,230,303...177,265,131
Ensembl chr 2:177,227,595...177,392,697
JBrowse link
G NHLRC3 NHL repeat containing 3 affects response to substance EXP NHLRC3 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr13:39,038,311...39,050,109
Ensembl chr13:39,038,306...39,050,109
JBrowse link
G NQO1 NAD(P)H quinone dehydrogenase 1 multiple interactions
increases reduction
increases metabolic processing
increases expression
ISO
EXP
KEAP1 protein inhibits the reaction [NQO1 protein results in increased metabolism of N-acetyl-4-benzoquinoneimine]; NFE2L2 protein affects the reaction [N-acetyl-4-benzoquinoneimine results in increased expression of NQO1 mRNA]; NFE2L2 protein promotes the reaction [NQO1 protein results in increased metabolism of N-acetyl-4-benzoquinoneimine]
NQO1 protein inhibits the reaction [GSTP1 protein results in increased glutathionylation of N-acetyl-4-benzoquinoneimine]
NQO1 protein results in increased reduction of N-acetyl-4-benzoquinoneimine
CTD PMID:17188792 PMID:18785192 PMID:19246624 PMID:24552538 NCBI chr16:69,709,401...69,726,560
Ensembl chr16:69,706,996...69,726,668
JBrowse link
G NQO2 N-ribosyldihydronicotinamide:quinone reductase 2 multiple interactions EXP NQO2 protein results in increased reduction of and results in decreased glutathionylation of N-acetyl-4-benzoquinoneimine; Tacrine inhibits the reaction [NQO2 protein results in increased reduction of N-acetyl-4-benzoquinoneimine] CTD PMID:29281794 NCBI chr 6:2,999,894...3,019,755
Ensembl chr 6:2,987,987...3,019,755
JBrowse link
G NUFIP1P1 NUFIP1 pseudogene 1 affects response to substance EXP NUFIP1P1 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr 6:66,091,475...66,094,945
Ensembl chr 6:66,093,431...66,094,909
JBrowse link
G PCBD2 pterin-4 alpha-carbinolamine dehydratase 2 affects response to substance EXP PCBD2 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr 5:134,905,131...134,962,644
Ensembl chr 5:134,905,120...135,007,959
JBrowse link
G PVT1 Pvt1 oncogene affects response to substance EXP PVT1 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr 8:127,794,533...128,101,253
Ensembl chr 8:127,794,526...128,187,101
JBrowse link
G RAB3IL1 RAB3A interacting protein like 1 affects response to substance EXP RAB3IL1 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr11:61,897,299...61,946,312
Ensembl chr11:61,897,301...61,920,269
JBrowse link
G RAP1GAP2 RAP1 GTPase activating protein 2 affects response to substance EXP RAP1GAP2 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr17:2,755,686...3,037,741
Ensembl chr17:2,755,705...3,037,741
JBrowse link
G RPS17P2 ribosomal protein S17 pseudogene 2 affects response to substance EXP RPS17P2 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr 5:116,716,218...116,716,696
Ensembl chr 5:116,716,243...116,716,650
JBrowse link
G RPS17P5 ribosomal protein S17 pseudogene 5 affects response to substance EXP RPS17P5 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr 6:50,857,209...50,857,687
Ensembl chr 6:50,857,255...50,857,662
JBrowse link
G SLC39A11 solute carrier family 39 member 11 affects response to substance EXP SLC39A11 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr17:72,645,949...73,092,714
Ensembl chr17:72,645,949...73,092,712
JBrowse link
G SLIT2 slit guidance ligand 2 affects response to substance EXP SLIT2 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr 4:20,251,905...20,620,561
Ensembl chr 4:20,251,905...20,620,561
JBrowse link
G SNX16 sorting nexin 16 affects response to substance EXP SNX16 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr 8:81,799,583...81,842,326
Ensembl chr 8:81,799,581...81,842,866
JBrowse link
G SOD1 superoxide dismutase 1 multiple interactions ISO [GPX1 protein co-treated with SOD1 protein] affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:16636302 NCBI chr21:31,659,693...31,668,931
Ensembl chr21:31,659,666...31,668,931
JBrowse link
G SPAG16 sperm associated antigen 16 affects response to substance EXP SPAG16 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr 2:213,284,369...214,410,501
Ensembl chr 2:213,284,379...214,410,501
JBrowse link
G STAB1 stabilin 1 affects response to substance EXP STAB1 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr 3:52,495,338...52,524,496
Ensembl chr 3:52,495,338...52,524,495
JBrowse link
G SYNE3 spectrin repeat containing nuclear envelope family member 3 affects response to substance EXP SYNE3 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr14:95,407,266...95,516,650
Ensembl chr14:95,407,266...95,516,650
JBrowse link
G TAC1 tachykinin precursor 1 increases secretion ISO N-acetyl-4-benzoquinoneimine results in increased secretion of TAC1 protein CTD PMID:20720158 NCBI chr 7:97,732,086...97,740,472
Ensembl chr 7:97,732,084...97,740,472
JBrowse link
G TGFB1 transforming growth factor beta 1 increases expression EXP N-acetyl-4-benzoquinoneimine results in increased expression of TGFB1 mRNA CTD PMID:28286204 NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922
JBrowse link
G TIMP1 TIMP metallopeptidase inhibitor 1 increases expression EXP N-acetyl-4-benzoquinoneimine results in increased expression of TIMP1 mRNA CTD PMID:28286204 NCBI chr  X:47,582,408...47,586,789
Ensembl chr  X:47,582,408...47,586,789
JBrowse link
G TMPRSS2 transmembrane serine protease 2 affects response to substance EXP TMPRSS2 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr21:41,464,305...41,508,158
Ensembl chr21:41,464,300...41,531,116
JBrowse link
G TOP2A DNA topoisomerase II alpha decreases activity EXP N-acetyl-4-benzoquinoneimine results in decreased activity of TOP2A protein CTD PMID:15035644 NCBI chr17:40,388,525...40,417,902
Ensembl chr17:40,388,525...40,417,896
JBrowse link
G TPD52L1 TPD52 like 1 affects response to substance EXP TPD52L1 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr 6:125,153,730...125,264,407
Ensembl chr 6:125,119,049...125,264,407
JBrowse link
G TRPA1 transient receptor potential cation channel subfamily A member 1 increases activity
affects response to substance
multiple interactions
EXP
ISO
N-acetyl-4-benzoquinoneimine results in increased activity of TRPA1 protein
TRPA1 affects the susceptibility to N-acetyl-4-benzoquinoneimine
2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide inhibits the reaction [N-acetyl-4-benzoquinoneimine results in increased activity of TRPA1 protein]
CTD PMID:20720158 NCBI chr 8:72,021,250...72,094,885
Ensembl chr 8:72,019,917...72,075,584
JBrowse link
G TXNRD1 thioredoxin reductase 1 decreases activity
multiple interactions
ISO N-acetyl-4-benzoquinoneimine results in decreased activity of TXNRD1 protein
Glutathione inhibits the reaction [N-acetyl-4-benzoquinoneimine results in decreased activity of TXNRD1 protein]
CTD PMID:24661219 NCBI chr12:104,215,779...104,350,307
Ensembl chr12:104,215,779...104,350,307
JBrowse link
G UBASH3A ubiquitin associated and SH3 domain containing A affects response to substance EXP UBASH3A gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr21:42,403,880...42,447,684
Ensembl chr21:42,403,447...42,447,684
JBrowse link
G UBE2E2 ubiquitin conjugating enzyme E2 E2 affects response to substance EXP UBE2E2 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr 3:23,203,007...23,591,925
Ensembl chr 3:23,203,020...23,591,794
JBrowse link
G VWC2 von Willebrand factor C domain containing 2 affects response to substance EXP VWC2 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr 7:49,773,638...49,923,777
Ensembl chr 7:49,773,638...49,921,950
JBrowse link
G WFDC3 WAP four-disulfide core domain 3 affects response to substance EXP WFDC3 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr20:45,708,860...45,791,883
Ensembl chr20:45,747,944...45,791,932
JBrowse link
pararosaniline free base term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BCHE butyrylcholinesterase decreases activity EXP pararosaniline results in decreased activity of BCHE protein CTD PMID:16036213 NCBI chr 3:165,772,904...165,837,423
Ensembl chr 3:165,772,904...165,837,462
JBrowse link
G GSTP1 glutathione S-transferase pi 1 multiple interactions EXP pararosaniline inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate] CTD PMID:23769903 NCBI chr11:67,583,812...67,586,653
Ensembl chr11:67,583,742...67,586,656
JBrowse link
G NR3C1 nuclear receptor subfamily 3 group C member 1 decreases expression
decreases activity
EXP pararosaniline results in decreased expression of NR3C1 protein
pararosaniline results in decreased activity of NR3C1 protein
CTD PMID:19255438 NCBI chr 5:143,277,931...143,435,512
Ensembl chr 5:143,277,931...143,435,512
JBrowse link
sirtinol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACACA acetyl-CoA carboxylase alpha multiple interactions EXP sirtinol inhibits the reaction [S-allylcysteine results in increased phosphorylation of ACACA protein] CTD PMID:23465592 NCBI chr17:37,084,992...37,406,836
Ensembl chr17:37,084,992...37,406,836
JBrowse link
G AHR aryl hydrocarbon receptor multiple interactions EXP AHR mutant form inhibits the reaction [sirtinol results in increased expression of CYP1A1 mRNA]; AHR mutant form inhibits the reaction [sirtinol results in increased expression of NQO1 mRNA] CTD PMID:22495798 NCBI chr 7:17,298,652...17,346,147
Ensembl chr 7:16,916,359...17,346,152
JBrowse link
G AKT1 AKT serine/threonine kinase 1 multiple interactions ISO sirtinol inhibits the reaction [resveratrol inhibits the reaction [Doxorubicin results in decreased phosphorylation of AKT1 protein]] CTD PMID:26450947 NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,751
JBrowse link
G APP amyloid beta precursor protein multiple interactions ISO sirtinol inhibits the reaction [cilostazol inhibits the reaction [APP protein results in decreased expression of and results in decreased activity of SIRT1 protein]] CTD PMID:24254769 NCBI chr21:25,880,550...26,171,128
Ensembl chr21:25,880,550...26,171,128
JBrowse link
G BAX BCL2 associated X, apoptosis regulator multiple interactions ISO
EXP
sirtinol inhibits the reaction [resveratrol inhibits the reaction [Doxorubicin results in increased expression of BAX protein]]
sirtinol inhibits the reaction [rhodioloside inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of BAX protein]]; sirtinol promotes the reaction [cudraflavone B results in increased expression of BAX protein]
CTD PMID:23881456 PMID:25665036 PMID:26450947 PMID:28851138 NCBI chr19:48,954,825...48,961,798
Ensembl chr19:48,954,815...48,961,798
JBrowse link
G BCL2 BCL2 apoptosis regulator multiple interactions EXP sirtinol inhibits the reaction [rhodioloside inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of BCL2 protein]]; sirtinol promotes the reaction [cudraflavone B results in decreased expression of BCL2 protein] CTD PMID:23881456 PMID:28851138 NCBI chr18:63,123,346...63,320,280
Ensembl chr18:63,123,346...63,320,128
JBrowse link
G CASP3 caspase 3 multiple interactions EXP
ISO
sirtinol inhibits the reaction [Resveratrol results in increased activity of CASP3 protein]; sirtinol inhibits the reaction [rhodioloside inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased activity of CASP3 protein]]; sirtinol promotes the reaction [cudraflavone B results in increased activity of CASP3 protein]
sirtinol inhibits the reaction [resveratrol inhibits the reaction [Hydrogen Peroxide results in increased expression of CASP3 protein modified form]]; sirtinol promotes the reaction [Hydrogen Peroxide results in increased expression of CASP3 protein modified form]
sirtinol inhibits the reaction [resveratrol inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein]]; sirtinol results in increased cleavage of and results in increased activity of CASP3 protein
CTD PMID:20697895 PMID:23881456 PMID:24889822 PMID:25665036 PMID:26251326 PMID:26450947 PMID:28851138 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,649,509
JBrowse link
G CASP9 caspase 9 multiple interactions EXP sirtinol inhibits the reaction [resveratrol results in increased activity of CASP9 protein] CTD PMID:20697895 NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534
JBrowse link
G CCL2 C-C motif chemokine ligand 2 multiple interactions EXP sirtinol inhibits the reaction [resveratrol inhibits the reaction [IL1B protein results in increased expression of CCL2 mRNA]] CTD PMID:20531350 NCBI chr17:34,255,285...34,257,203
Ensembl chr17:34,255,218...34,257,203
JBrowse link
G CCL20 C-C motif chemokine ligand 20 increases expression EXP sirtinol results in increased expression of CCL20 mRNA CTD PMID:22385246 NCBI chr 2:227,813,842...227,817,556
Ensembl chr 2:227,805,739...227,817,564
JBrowse link
G CD40 CD40 molecule multiple interactions ISO sirtinol promotes the reaction [TNF protein results in increased expression of CD40 mRNA] CTD PMID:22717288 NCBI chr20:46,118,242...46,129,858
Ensembl chr20:46,118,278...46,129,863
JBrowse link
G CDKN1A cyclin dependent kinase inhibitor 1A increases expression
multiple interactions
EXP sirtinol results in increased expression of CDKN1A mRNA; sirtinol results in increased expression of CDKN1A protein
sirtinol promotes the reaction [cudraflavone B results in increased expression of CDKN1A protein]
CTD PMID:22495798 PMID:23881456 NCBI chr 6:36,676,463...36,687,332
Ensembl chr 6:36,676,460...36,687,337
JBrowse link
G CDKN1B cyclin dependent kinase inhibitor 1B multiple interactions EXP sirtinol promotes the reaction [cudraflavone B results in increased expression of CDKN1B protein] CTD PMID:23881456 NCBI chr12:12,717,368...12,722,369
Ensembl chr12:12,685,498...12,722,369
JBrowse link
G COL10A1 collagen type X alpha 1 chain decreases expression ISO sirtinol results in decreased expression of COL10A1 protein CTD PMID:26251326 NCBI chr 6:116,118,909...116,219,937
Ensembl chr 6:116,118,909...116,158,747
JBrowse link
G COL1A1 collagen type I alpha 1 chain decreases expression ISO sirtinol results in decreased expression of COL1A1 protein CTD PMID:26251326 NCBI chr17:50,184,096...50,201,649
Ensembl chr17:50,184,101...50,201,632
JBrowse link
G COL2A1 collagen type II alpha 1 chain decreases expression ISO sirtinol results in decreased expression of COL2A1 protein CTD PMID:26251326 NCBI chr12:47,972,967...48,006,212
Ensembl chr12:47,972,967...48,004,554
JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 increases expression EXP sirtinol results in increased expression of CXCL8 mRNA CTD PMID:22385246 NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,541...73,743,716
JBrowse link
G CYBA cytochrome b-245 alpha chain increases expression ISO sirtinol results in increased expression of CYBA mRNA CTD PMID:23422569 NCBI chr16:88,643,289...88,651,079
Ensembl chr16:88,643,289...88,651,054
JBrowse link
G CYBB cytochrome b-245 beta chain multiple interactions EXP sirtinol inhibits the reaction [rhodioloside inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of NOX2 protein]] CTD PMID:28851138 NCBI chr  X:37,780,059...37,813,461
Ensembl chr  X:37,780,059...37,813,461
JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 increases expression
multiple interactions
EXP sirtinol results in increased expression of CYP1A1 mRNA
AHR mutant form inhibits the reaction [sirtinol results in increased expression of CYP1A1 mRNA]
CTD PMID:22495798 NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536
JBrowse link
G EP300 E1A binding protein p300 multiple interactions ISO sirtinol inhibits the reaction [cilostazol affects the expression of EP300 protein]; sirtinol inhibits the reaction [resveratrol inhibits the reaction [Doxorubicin results in increased expression of EP300 protein]] CTD PMID:24254769 PMID:25665036 NCBI chr22:41,092,592...41,180,077
Ensembl chr22:41,092,592...41,180,077
JBrowse link
G F3 coagulation factor III, tissue factor multiple interactions EXP sirtinol promotes the reaction [TNF protein results in increased expression of F3 mRNA]; sirtinol promotes the reaction [TNF protein results in increased expression of F3 protein] CTD PMID:20978007 NCBI chr 1:94,529,173...94,541,759
Ensembl chr 1:94,529,173...94,541,759
JBrowse link
G FBXO32 F-box protein 32 multiple interactions EXP [sirtinol results in decreased activity of SIRT1 protein] which results in decreased expression of FBXO32 mRNA CTD PMID:22146233 NCBI chr 8:123,497,889...123,541,206
Ensembl chr 8:123,497,889...123,541,206
JBrowse link
G FOXO1 forkhead box O1 multiple interactions
increases acetylation
ISO sirtinol inhibits the reaction [resveratrol inhibits the reaction [Doxorubicin results in increased acetylation of FOXO1 protein]]
sirtinol results in increased acetylation of FOXO1 protein
sirtinol inhibits the reaction [resveratrol inhibits the reaction [Hydrogen Peroxide results in increased acetylation of FOXO1 protein]]; sirtinol promotes the reaction [Hydrogen Peroxide results in increased acetylation of FOXO1 protein]
CTD PMID:24889822 PMID:25665036 NCBI chr13:40,555,667...40,666,641
Ensembl chr13:40,555,667...40,666,641
JBrowse link
G GH1 growth hormone 1 multiple interactions
increases secretion
increases expression
ISO sirtinol inhibits the reaction [resveratrol results in decreased secretion of GH1 protein]
sirtinol results in increased secretion of GH1 protein
sirtinol results in increased expression of GH1 mRNA
CTD PMID:23292070 NCBI chr17:63,917,203...63,918,839
Ensembl chr17:63,917,200...63,918,839
JBrowse link
G IGF1R insulin like growth factor 1 receptor decreases expression EXP sirtinol results in decreased expression of IGF1R mRNA CTD PMID:22495798 NCBI chr15:98,648,539...98,964,530
Ensembl chr15:98,648,539...98,964,530
JBrowse link
G IGFBP3 insulin like growth factor binding protein 3 increases expression EXP sirtinol results in increased expression of IGFBP3 mRNA CTD PMID:22495798 NCBI chr 7:45,912,245...45,921,272
Ensembl chr 7:45,912,245...45,921,874
JBrowse link
G IL1B interleukin 1 beta multiple interactions
increases expression
EXP
ISO
sirtinol inhibits the reaction [resveratrol inhibits the reaction [IL1B protein results in increased expression of CCL2 mRNA]]
sirtinol inhibits the reaction [resveratrol inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]]
sirtinol results in increased expression of IL1B mRNA
CTD PMID:20531350 PMID:22385246 PMID:23973301 NCBI chr 2:112,829,751...112,836,843
Ensembl chr 2:112,829,751...112,836,816
JBrowse link
G KLF2 Kruppel like factor 2 multiple interactions EXP sirtinol inhibits the reaction [resveratrol results in increased expression of KLF2 mRNA] CTD PMID:19815564 NCBI chr19:16,324,826...16,328,685
Ensembl chr19:16,324,826...16,328,685
JBrowse link
G KLK3 kallikrein related peptidase 3 multiple interactions
decreases expression
EXP sirtinol inhibits the reaction [Estradiol results in increased expression of KLK3 mRNA]
sirtinol results in decreased expression of KLK3 mRNA; sirtinol results in decreased expression of KLK3 protein
CTD PMID:22495798 NCBI chr19:50,854,915...50,860,764
Ensembl chr19:50,854,915...50,860,764
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 decreases phosphorylation EXP sirtinol results in decreased phosphorylation of MAPK1 protein CTD PMID:21745208 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 decreases phosphorylation EXP sirtinol results in decreased phosphorylation of MAPK3 protein CTD PMID:21745208 NCBI chr16:30,114,105...30,123,309
Ensembl chr16:30,114,105...30,123,506
JBrowse link
G MYC MYC proto-oncogene, bHLH transcription factor multiple interactions ISO sirtinol inhibits the reaction [resveratrol results in decreased expression of MYC protein] CTD PMID:24395567 NCBI chr 8:127,735,434...127,742,951
Ensembl chr 8:127,735,434...127,742,951
JBrowse link
G NFE2L2 nuclear factor, erythroid 2 like 2 multiple interactions ISO sirtinol inhibits the reaction [resveratrol results in increased expression of NFE2L2 protein] CTD PMID:24395567 NCBI chr 2:177,230,303...177,265,131
Ensembl chr 2:177,227,595...177,392,697
JBrowse link
G NFKBIA NFKB inhibitor alpha increases degradation EXP sirtinol results in increased degradation of NFKBIA protein CTD PMID:21745208 NCBI chr14:35,401,513...35,404,749
Ensembl chr14:35,401,513...35,404,749
JBrowse link
G NKX3-1 NK3 homeobox 1 decreases expression EXP sirtinol results in decreased expression of NKX3-1 mRNA CTD PMID:22495798 NCBI chr 8:23,678,693...23,682,938
Ensembl chr 8:23,678,697...23,682,938
JBrowse link
G NOX4 NADPH oxidase 4 multiple interactions
increases expression
ISO resveratrol inhibits the reaction [sirtinol results in increased expression of NOX4 mRNA] CTD PMID:23422569 NCBI chr11:89,324,353...89,589,557
Ensembl chr11:89,324,353...89,498,187
JBrowse link
G NQO1 NAD(P)H quinone dehydrogenase 1 multiple interactions
increases expression
EXP AHR mutant form inhibits the reaction [sirtinol results in increased expression of NQO1 mRNA] CTD PMID:22495798 NCBI chr16:69,709,401...69,726,560
Ensembl chr16:69,706,996...69,726,668
JBrowse link
G NR0B2 nuclear receptor subfamily 0 group B member 2 multiple interactions EXP sirtinol inhibits the reaction [resveratrol results in increased expression of NR0B2 mRNA] CTD PMID:26044878 NCBI chr 1:26,911,489...26,914,110
Ensembl chr 1:26,911,489...26,913,975
JBrowse link
G PDK1 pyruvate dehydrogenase kinase 1 multiple interactions ISO sirtinol inhibits the reaction [resveratrol results in decreased expression of PDK1 protein] CTD PMID:24395567 NCBI chr 2:172,555,373...172,672,698
Ensembl chr 2:172,555,373...172,608,669
JBrowse link
G PDK4 pyruvate dehydrogenase kinase 4 multiple interactions ISO sirtinol inhibits the reaction [resveratrol inhibits the reaction [Doxorubicin results in increased expression of PDK4 protein]] CTD PMID:26450947 NCBI chr 7:95,583,499...95,596,516
Ensembl chr 7:95,583,499...95,596,516
JBrowse link
G PDPK1 3-phosphoinositide dependent protein kinase 1 multiple interactions ISO sirtinol inhibits the reaction [resveratrol inhibits the reaction [Doxorubicin results in decreased expression of PDPK1 protein]] CTD PMID:26450947 NCBI chr16:2,538,014...2,603,190
Ensembl chr16:2,537,979...2,603,188
JBrowse link
G PPARGC1A PPARG coactivator 1 alpha multiple interactions EXP
ISO
sirtinol inhibits the reaction [Melatonin inhibits the reaction [Cadmium Chloride results in increased acetylation of PPARGC1A protein]]; sirtinol inhibits the reaction [Melatonin inhibits the reaction [Cadmium results in increased acetylation of PPARGC1A protein]]
sirtinol inhibits the reaction [genipin inhibits the reaction [[Blood Glucose deficiency co-treated with Oxygen deficiency] results in decreased expression of PPARGC1A protein]]
sirtinol inhibits the reaction [resveratrol results in increased expression of PPARGC1A protein]
CTD PMID:24395567 PMID:25159133 PMID:28477916 NCBI chr 4:23,792,021...24,472,905
Ensembl chr 4:23,755,041...23,904,089
JBrowse link
G PRKN parkin RBR E3 ubiquitin protein ligase multiple interactions ISO sirtinol inhibits the reaction [genipin inhibits the reaction [[Blood Glucose deficiency co-treated with Oxygen deficiency] results in decreased expression of PRKN protein]] CTD PMID:28477916 NCBI chr 6:161,347,417...162,727,802
Ensembl chr 6:161,347,417...162,727,775
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP sirtinol inhibits the reaction [resveratrol inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]] CTD PMID:23257246 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922
JBrowse link
G RB1 RB transcriptional corepressor 1 multiple interactions EXP sirtinol promotes the reaction [cudraflavone B results in decreased phosphorylation of RB1 protein] CTD PMID:23881456 NCBI chr13:48,303,751...48,481,890
Ensembl chr13:48,303,744...48,599,436
JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit multiple interactions
increases localization
EXP
ISO
sirtinol inhibits the reaction [resveratrol inhibits the reaction [TNF protein results in increased acetylation of RELA protein]]
sirtinol promotes the reaction [TNF protein results in increased acetylation of RELA protein]
sirtinol results in increased localization of RELA protein
CTD PMID:21745208 PMID:22717288 PMID:23257246 NCBI chr11:65,653,601...65,662,946
Ensembl chr11:65,653,597...65,663,090
JBrowse link
G SHC1 SHC adaptor protein 1 multiple interactions
increases expression
EXP sirtinol inhibits the reaction [SIRT1 protein binds to SHC1 promoter]
sirtinol results in increased expression of SHC1 mRNA; sirtinol results in increased expression of SHC1 protein
CTD PMID:21778425 NCBI chr 1:154,962,298...154,974,492
Ensembl chr 1:154,962,298...154,974,395
JBrowse link
G SIRT1 sirtuin 1 decreases activity
multiple interactions
EXP
ISO
sirtinol analog results in decreased activity of SIRT1 protein; sirtinol results in decreased activity of SIRT1 protein
sirtinol inhibits the reaction [cobaltous chloride results in increased expression of SIRT1 protein]; sirtinol inhibits the reaction [resveratrol results in increased expression of and results in increased activity of SIRT1 protein]
[sirtinol results in decreased activity of SIRT1 protein] which results in decreased susceptibility to Glucose; sirtinol inhibits the reaction [cilostazol inhibits the reaction [APP protein results in decreased expression of and results in decreased activity of SIRT1 protein]]; sirtinol inhibits the reaction [cilostazol results in increased phosphorylation of SIRT1 protein]; sirtinol inhibits the reaction [genipin inhibits the reaction [[Blood Glucose deficiency co-treated with Oxygen deficiency] results in decreased expression of SIRT1 protein]]; sirtinol inhibits the reaction [resveratrol inhibits the reaction [Doxorubicin results in decreased activity of SIRT1 protein]]; sirtinol inhibits the reaction [resveratrol inhibits the reaction [Lipopolysaccharides results in decreased expression of SIRT1 protein]]
[sirtinol results in decreased activity of SIRT1 protein] promotes the reaction [Hydrogen Peroxide results in increased acetylation of TP53 protein]; [sirtinol results in decreased activity of SIRT1 protein] which results in decreased expression of FBXO32 mRNA; [sirtinol results in decreased activity of SIRT1 protein] which results in decreased susceptibility to Plant Extracts; [sirtinol results in decreased activity of SIRT1 protein] which results in decreased susceptibility to Resveratrol; [sirtinol results in decreased activity of SIRT1 protein] which results in increased susceptibility to Hydrogen Peroxide; sirtinol inhibits the reaction [[Resveratrol co-treated with TNF protein] results in increased expression of SIRT1 protein]; sirtinol inhibits the reaction [cudraflavone B results in increased expression of SIRT1 mRNA]; sirtinol inhibits the reaction [cudraflavone B results in increased expression of SIRT1 protein]; sirtinol inhibits the reaction [Melatonin inhibits the reaction [Cadmium Chloride results in decreased expression of and results in decreased activity of SIRT1 protein]]; sirtinol inhibits the reaction [Melatonin inhibits the reaction [Cadmium results in decreased expression of and results in decreased activity of SIRT1 protein]]; sirtinol inhibits the reaction [SIRT1 protein binds to SHC1 promoter]
CTD PMID:16302818 PMID:18681908 PMID:19288225 PMID:20370652 PMID:20531350 PMID:20610621 PMID:20697895 PMID:20978007 PMID:21745208 PMID:21778425 PMID:22146233 PMID:22385246 PMID:22563892 PMID:22669716 PMID:23257246 PMID:23315983 PMID:23479127 PMID:23881456 PMID:23973301 PMID:24254769 PMID:24395567 PMID:24998427 PMID:25159133 PMID:25665036 PMID:26450947 PMID:28477916 NCBI chr10:67,884,656...67,918,390
Ensembl chr10:67,884,656...67,918,390
JBrowse link
G SIRT2 sirtuin 2 decreases activity EXP sirtinol analog results in decreased activity of SIRT2 protein; sirtinol results in decreased activity of SIRT2 protein CTD PMID:16302818 PMID:24998427 NCBI chr19:38,878,555...38,899,733
Ensembl chr19:38,878,555...38,899,862
JBrowse link
G SMAD1 SMAD family member 1 decreases phosphorylation EXP sirtinol results in decreased phosphorylation of SMAD1 protein CTD PMID:21745208 NCBI chr 4:145,481,306...145,559,176
Ensembl chr 4:145,481,194...145,559,176
JBrowse link
G SMAD5 SMAD family member 5 decreases phosphorylation EXP sirtinol results in decreased phosphorylation of SMAD5 protein CTD PMID:21745208 NCBI chr 5:136,132,845...136,182,733
Ensembl chr 5:136,132,845...136,188,747
JBrowse link
G SMAD9 SMAD family member 9 decreases phosphorylation EXP sirtinol results in decreased phosphorylation of SMAD9 protein CTD PMID:21745208 NCBI chr13:36,844,831...36,920,721
Ensembl chr13:36,844,831...36,920,765
JBrowse link
G SQSTM1 sequestosome 1 multiple interactions ISO sirtinol inhibits the reaction [resveratrol inhibits the reaction [Hydrogen Peroxide results in increased expression of SQSTM1 protein]]; sirtinol promotes the reaction [Hydrogen Peroxide results in increased expression of SQSTM1 protein] CTD PMID:24889822 NCBI chr 5:179,806,393...179,838,078
Ensembl chr 5:179,806,398...179,838,078
JBrowse link
G SREBF1 sterol regulatory element binding transcription factor 1 multiple interactions EXP sirtinol inhibits the reaction [S-allylcysteine results in decreased expression of SREBF1 protein] CTD PMID:23465592 NCBI chr17:17,811,334...17,837,017
Ensembl chr17:17,810,399...17,837,002
JBrowse link
G TNF tumor necrosis factor multiple interactions
increases expression
EXP
ISO
sirtinol inhibits the reaction [[resveratrol co-treated with TNF protein] results in increased expression of SIRT1 protein]; sirtinol inhibits the reaction [resveratrol inhibits the reaction [TNF protein results in increased acetylation of RELA protein]]; sirtinol inhibits the reaction [resveratrol inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]]; sirtinol promotes the reaction [TNF protein results in increased expression of F3 mRNA]; sirtinol promotes the reaction [TNF protein results in increased expression of F3 protein]
Sirtinol promotes the reactions [Lipopolysaccharide, acetate, acetaldehyde increases secretion of Tnf protein from Kupffer cells]
sirtinol inhibits the reaction [resveratrol inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]]; sirtinol promotes the reaction [TNF protein results in increased acetylation of RELA protein]; sirtinol promotes the reaction [TNF protein results in increased expression of CD40 mRNA]
sirtinol results in increased expression of TNF mRNA
CTD PMID:20978007 PMID:22385246 PMID:22717288 PMID:23257246 PMID:23973301, PMID:19299582 RGD:9585771 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
JBrowse link
G TP53 tumor protein p53 multiple interactions EXP
ISO
[sirtinol results in decreased activity of SIRT1 protein] promotes the reaction [Hydrogen Peroxide results in increased acetylation of TP53 protein]; sirtinol promotes the reaction [arsenic disulfide results in increased expression of and results in increased phosphorylation of TP53 protein]; sirtinol promotes the reaction [cudraflavone B results in increased expression of TP53 protein]
sirtinol inhibits the reaction [resveratrol inhibits the reaction [Doxorubicin results in increased expression of TRP53 protein]]
CTD PMID:18298901 PMID:18681908 PMID:23881456 PMID:25665036 NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,538
JBrowse link
G TRIM63 tripartite motif containing 63 multiple interactions ISO sirtinol inhibits the reaction [resveratrol inhibits the reaction [Doxorubicin results in increased expression of TRIM63 protein]] CTD PMID:25665036 PMID:26450947 NCBI chr 1:26,051,301...26,067,633
Ensembl chr 1:26,051,301...26,068,436
JBrowse link
G USP7 ubiquitin specific peptidase 7 multiple interactions ISO sirtinol inhibits the reaction [resveratrol inhibits the reaction [Doxorubicin results in increased expression of USP7 protein]] CTD PMID:25665036 NCBI chr16:8,892,097...8,963,912
Ensembl chr16:8,892,097...8,975,328
JBrowse link
G VEGFA vascular endothelial growth factor A multiple interactions ISO [sirtinol co-treated with cobaltous chloride] results in increased cleavage of VEGFA protein; sirtinol inhibits the reaction [cobaltous chloride results in increased secretion of VEGFA protein] CTD PMID:22669716 NCBI chr 6:43,770,209...43,786,487
Ensembl chr 6:43,770,184...43,786,487
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 24824
    chemical entity 24794
      atom 24784
        nonmetal atom 24520
          carbon atom 24410
            organic molecular entity 24410
              imine 195
                1-pyrroline 0
                2,6-dichlorophenol-4-(2,3-dihydro-1,4-naphthoquinone imine) 0
                2-chloro-3-(3-methoxypropylimino)naphthalene-1,4-dione 0
                2-chloro-3-propan-2-yliminonaphthalene-1,4-dione 0
                2-hydroxy-5-[(1E)-(2-phenylethylidene)amino]-L-tyrosine 0
                2-methyl-1-pyrroline 0
                3,4-dihydroxy-5-(2-hydroxyethanimidoyl)oxolan-2-one 0
                3-methyl-4-[(4'-methyl[2,2'-bipyridin]-4-yl)imino]but-2-en-2-amine 0
                Hoffman's violet free base 0
                Methyl violet 2B free base 0
                N-[(E)-4-aminobutylidene]propane-1,3-diamine 0
                N-[3-(2-methoxyphenyl)imino-1,4-dioxo-2-naphthalenyl]acetamide 0
                SRS16-86 0
                Schiff base + 0
                acid fuchsin (free acid form) 0
                acridine red 3B free base 0
                acylimine + 0
                aldimine + 60
                alkali Blue G 0
                auramine O free base 0
                azaxylylene + 0
                azocarmine B free acid 0
                azocarmine G free acid 0
                clitidine 0
                dehydroglycine 0
                iminopiperidine + 0
                ketenimine 0
                ketimine + 78
                magenta II free base 0
                methyl blue free acid 0
                new fuchsin free base 0
                nitrone + 3
                pararosaniline free base 3
                pyrimidinimine + 0
                quinone imine + 139
                rosanilin free base 0
                spirit blue base 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 24824
    subatomic particle 24784
      composite particle 24784
        hadron 24784
          baryon 24784
            nucleon 24784
              atomic nucleus 24784
                atom 24784
                  main group element atom 24651
                    p-block element atom 24651
                      p-block molecular entity 24644
                        carbon group molecular entity 24446
                          organic molecular entity 24410
                            heteroorganic entity 23810
                              organonitrogen compound 20868
                                imine 195
                                  1-pyrroline 0
                                  2,6-dichlorophenol-4-(2,3-dihydro-1,4-naphthoquinone imine) 0
                                  2-chloro-3-(3-methoxypropylimino)naphthalene-1,4-dione 0
                                  2-chloro-3-propan-2-yliminonaphthalene-1,4-dione 0
                                  2-hydroxy-5-[(1E)-(2-phenylethylidene)amino]-L-tyrosine 0
                                  2-methyl-1-pyrroline 0
                                  3,4-dihydroxy-5-(2-hydroxyethanimidoyl)oxolan-2-one 0
                                  3-methyl-4-[(4'-methyl[2,2'-bipyridin]-4-yl)imino]but-2-en-2-amine 0
                                  Hoffman's violet free base 0
                                  Methyl violet 2B free base 0
                                  N-[(E)-4-aminobutylidene]propane-1,3-diamine 0
                                  N-[3-(2-methoxyphenyl)imino-1,4-dioxo-2-naphthalenyl]acetamide 0
                                  SRS16-86 0
                                  Schiff base + 0
                                  acid fuchsin (free acid form) 0
                                  acridine red 3B free base 0
                                  acylimine + 0
                                  aldimine + 60
                                  alkali Blue G 0
                                  auramine O free base 0
                                  azaxylylene + 0
                                  azocarmine B free acid 0
                                  azocarmine G free acid 0
                                  clitidine 0
                                  dehydroglycine 0
                                  iminopiperidine + 0
                                  ketenimine 0
                                  ketimine + 78
                                  magenta II free base 0
                                  methyl blue free acid 0
                                  new fuchsin free base 0
                                  nitrone + 3
                                  pararosaniline free base 3
                                  pyrimidinimine + 0
                                  quinone imine + 139
                                  rosanilin free base 0
                                  spirit blue base 0
paths to the root