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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:hydroxytoluene
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Accession:CHEBI:24751 term browser browse the term
Definition:Any member of the class of toluenes carrying one or more hydroxy substituents.
Synonyms:related_synonym: hydroxytoluenes


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2,4-Dimethylphenol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Trpa1 transient receptor potential cation channel, subfamily A, member 1 increases activity ISO 2,4-dimethylphenol results in increased activity of TRPA1 protein CTD PMID:29658714 NCBI chr 5:3,783,247...3,836,485
Ensembl chr 5:3,783,247...3,836,485
JBrowse link
G Trpv3 transient receptor potential cation channel, subfamily V, member 3 increases activity ISO 2,4-dimethylphenol results in increased activity of TRPV3 protein CTD PMID:29658714 NCBI chr10:59,829,755...59,863,780
Ensembl chr10:59,831,241...59,860,987
JBrowse link
4-chloro-2-methylphenol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ar androgen receptor affects binding EXP 4-chloro-2-cresol binds to AR protein CTD PMID:14565775 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
4-chloro-m-cresol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor affects activity ISO chlorocresol affects the activity of AHR protein CTD PMID:18294747 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Ar androgen receptor affects activity
multiple interactions
ISO chlorocresol affects the activity of AR protein
chlorocresol inhibits the reaction [Metribolone results in increased activity of AR protein]
CTD PMID:18294747, PMID:18324785 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Esrrg estrogen-related receptor gamma multiple interactions
affects binding
ISO chlorocresol inhibits the reaction [afimoxifene binds to ESRRG protein]
chlorocresol binds to ESRRG protein
CTD PMID:17964775 NCBI chr13:106,063,799...106,683,353
Ensembl chr13:106,463,368...106,683,436
JBrowse link
G Il10 interleukin 10 multiple interactions ISO [chlorocresol results in increased activity of RYR1 protein] inhibits the reaction [Lipopolysaccharides results in increased expression of IL10 protein]; Dantrolene inhibits the reaction [[chlorocresol results in increased activity of RYR1 protein] inhibits the reaction [Lipopolysaccharides results in increased expression of IL10 protein]] CTD PMID:17707769 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Ryr1 ryanodine receptor 1 increases activity
increases response to substance
affects response to substance
multiple interactions
ISO chlorocresol results in increased activity of RYR1 protein
RYR1 gene mutant form results in increased susceptibility to chlorocresol; RYR1 protein mutant form results in increased susceptibility to chlorocresol; RYR1 protein results in increased susceptibility to chlorocresol
RYR1 protein alternative form affects the susceptibility to chlorocresol
[chlorocresol results in increased activity of RYR1 protein] inhibits the reaction [Lipopolysaccharides results in increased expression of IL10 protein]; [chlorocresol results in increased activity of RYR1 protein] which affects the localization of Calcium; [chlorocresol results in increased activity of RYR1 protein] which results in increased transport of Calcium; Dantrolene inhibits the reaction [[chlorocresol results in increased activity of RYR1 protein] inhibits the reaction [Lipopolysaccharides results in increased expression of IL10 protein]]; Dantrolene inhibits the reaction [[chlorocresol results in increased activity of RYR1 protein] which results in increased transport of Calcium]; RYR1 protein polymorphism affects the reaction [chlorocresol results in increased secretion of Calcium]
CTD PMID:12810058, PMID:15210166, PMID:16372898, PMID:17707769, PMID:18719443, PMID:19191329, PMID:19191333, PMID:21485675 NCBI chr 1:87,959,596...88,066,252
Ensembl chr 1:87,959,712...88,066,101
JBrowse link
4-nitro-m-cresol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator increases expression
multiple interactions
ISO 4-nitro-3-cresol results in increased expression of BAX protein
Quercetin inhibits the reaction [4-nitro-3-cresol results in increased expression of BAX protein]
CTD PMID:22467373 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions
decreases expression
ISO Quercetin inhibits the reaction [4-nitro-3-cresol results in decreased expression of BCL2L1 protein] CTD PMID:22467373 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions
ISO 4-nitro-3-cresol results in increased activity of CASP3 protein
CASP3 protein promotes the reaction [4-nitro-3-cresol results in increased expression of FAS mRNA]; CASP3 protein promotes the reaction [4-nitro-3-cresol results in increased expression of FAS protein]; CASP3 protein promotes the reaction [4-nitro-3-cresol results in increased expression of FASLG mRNA]; CASP3 protein promotes the reaction [4-nitro-3-cresol results in increased expression of FASLG protein]
Quercetin inhibits the reaction [4-nitro-3-cresol results in increased activity of CASP3 protein]
CTD PMID:22467373, PMID:29307546 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp8 caspase 8 increases activity
multiple interactions
ISO 4-nitro-3-cresol results in increased activity of CASP8 protein
CASP8 protein promotes the reaction [4-nitro-3-cresol results in increased expression of FAS mRNA]; CASP8 protein promotes the reaction [4-nitro-3-cresol results in increased expression of FAS protein]; CASP8 protein promotes the reaction [4-nitro-3-cresol results in increased expression of FASLG mRNA]; CASP8 protein promotes the reaction [4-nitro-3-cresol results in increased expression of FASLG protein]
CTD PMID:29307546 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Fas Fas cell surface death receptor increases expression
multiple interactions
ISO 4-nitro-3-cresol results in increased expression of FAS mRNA; 4-nitro-3-cresol results in increased expression of FAS protein
CASP3 protein promotes the reaction [4-nitro-3-cresol results in increased expression of FAS mRNA]; CASP3 protein promotes the reaction [4-nitro-3-cresol results in increased expression of FAS protein]; CASP8 protein promotes the reaction [4-nitro-3-cresol results in increased expression of FAS mRNA]; CASP8 protein promotes the reaction [4-nitro-3-cresol results in increased expression of FAS protein]
CTD PMID:29307546 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790
JBrowse link
G Faslg Fas ligand multiple interactions
increases expression
ISO CASP3 protein promotes the reaction [4-nitro-3-cresol results in increased expression of FASLG mRNA]; CASP3 protein promotes the reaction [4-nitro-3-cresol results in increased expression of FASLG protein]; CASP8 protein promotes the reaction [4-nitro-3-cresol results in increased expression of FASLG mRNA]; CASP8 protein promotes the reaction [4-nitro-3-cresol results in increased expression of FASLG protein]
4-nitro-3-cresol results in increased expression of FASL mRNA; 4-nitro-3-cresol results in increased expression of FASL protein
4-nitro-3-cresol results in increased expression of FASLG mRNA; 4-nitro-3-cresol results in increased expression of FASLG protein
CTD PMID:29307546 NCBI chr13:79,696,811...79,717,581
Ensembl chr13:79,698,445...79,705,705
JBrowse link
G Hsd17b4 hydroxysteroid (17-beta) dehydrogenase 4 multiple interactions ISO [4-nitro-3-cresol co-treated with 8-Bromo Cyclic Adenosine Monophosphate] results in increased expression of HSD17B4 protein CTD PMID:18336853 NCBI chr18:44,810,462...44,897,677
Ensembl chr18:44,810,388...44,897,640
JBrowse link
G Hsd3b2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 multiple interactions ISO [4-nitro-3-cresol co-treated with 8-Bromo Cyclic Adenosine Monophosphate] results in decreased expression of HSD3B2 protein CTD PMID:18336853 NCBI chr 2:200,712,895...200,722,429
Ensembl chr 2:202,341,422...202,350,929
JBrowse link
G Pla2g3 phospholipase A2, group III decreases expression EXP 4-nitro-3-cresol results in decreased expression of PLA2G3 protein CTD PMID:29292090 NCBI chr14:83,724,828...83,730,614
Ensembl chr14:83,724,933...83,730,614
JBrowse link
ethiofencarb term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 multiple interactions ISO croneton inhibits the reaction [Hydrocortisone results in increased activity of NR3C1 protein] CTD PMID:26647222 NCBI chr18:31,728,373...32,704,022
Ensembl chr18:31,728,373...31,749,647
JBrowse link
fenamiphos term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase decreases activity
multiple interactions
ISO fenamiphos results in decreased activity of ACHE protein
fenamiphos binds to and results in increased phosphorylation of and results in decreased activity of ACHE protein
CTD PMID:17382909, PMID:17402711 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions
affects activity
ISO fenamiphos binds to and results in increased activity of NR1I2 protein
fenamiphos affects the activity of NR1I2 protein
CTD PMID:21115097, PMID:23611293 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
fenitrothion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc1 ATP binding cassette subfamily C member 1 decreases response to substance ISO ABCC1 protein results in decreased susceptibility to Fenitrothion CTD PMID:12765240 NCBI chr10:549,537...672,235
Ensembl chr10:549,883...672,196
JBrowse link
G Ache acetylcholinesterase decreases activity ISO
EXP
Fenitrothion results in decreased activity of ACHE protein CTD PMID:2086312, PMID:6933967 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
JBrowse link
G Ar androgen receptor multiple interactions
decreases activity
increases expression
affects binding
ISO Dihydrotestosterone inhibits the reaction [Fenitrothion results in increased activity of AR protein]; Fenitrothion analog binds to and results in decreased activity of AR protein; Fenitrothion inhibits the reaction [Dihydrotestosterone binds to and results in increased activity of AR protein]; Fenitrothion inhibits the reaction [Dihydrotestosterone results in increased expression of AR mRNA]; Fenitrothion inhibits the reaction [Metribolone results in increased activity of AR protein]
Fenitrothion results in decreased activity of AR protein
Fenitrothion results in increased expression of AR mRNA
Fenitrothion binds to AR protein
CTD PMID:11222873, PMID:12676613, PMID:15064155, PMID:15253041, PMID:18324785, PMID:21251949, PMID:21310686 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression
multiple interactions
EXP Fenitrothion results in increased expression of BAX mRNA
Fenitrothion promotes the reaction [Vehicle Emissions results in increased expression of BAX mRNA]; Plant Preparations inhibits the reaction [Fenitrothion promotes the reaction [Vehicle Emissions results in increased expression of BAX mRNA]]; Plant Preparations inhibits the reaction [Fenitrothion results in increased expression of BAX mRNA]; Plant Preparations inhibits the reaction [Vehicle Emissions promotes the reaction [Fenitrothion results in increased expression of BAX mRNA]]; Vehicle Emissions promotes the reaction [Fenitrothion results in increased expression of BAX mRNA]
CTD PMID:32572764 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator increases expression
decreases expression
multiple interactions
ISO
EXP
Fenitrothion results in increased expression of BCL2 mRNA
Fenitrothion results in decreased expression of BCL2 mRNA
Fenitrothion promotes the reaction [Vehicle Emissions results in decreased expression of BCL2 mRNA]; Plant Preparations inhibits the reaction [Fenitrothion promotes the reaction [Vehicle Emissions results in decreased expression of BCL2 mRNA]]; Plant Preparations inhibits the reaction [Fenitrothion results in decreased expression of BCL2 mRNA]; Plant Preparations inhibits the reaction [Vehicle Emissions promotes the reaction [Fenitrothion results in decreased expression of BCL2 mRNA]]; Vehicle Emissions promotes the reaction [Fenitrothion results in decreased expression of BCL2 mRNA]
CTD PMID:21298709, PMID:32572764 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Casp3 caspase 3 increases expression
multiple interactions
EXP Fenitrothion results in increased expression of CASP3 mRNA
Fenitrothion promotes the reaction [Vehicle Emissions results in increased expression of CASP3 mRNA]; Plant Preparations inhibits the reaction [Fenitrothion promotes the reaction [Vehicle Emissions results in increased expression of CASP3 mRNA]]; Plant Preparations inhibits the reaction [Fenitrothion results in increased expression of CASP3 mRNA]; Plant Preparations inhibits the reaction [Vehicle Emissions promotes the reaction [Fenitrothion results in increased expression of CASP3 mRNA]]; Vehicle Emissions promotes the reaction [Fenitrothion results in increased expression of CASP3 mRNA]
CTD PMID:32572764 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Cat catalase multiple interactions
decreases activity
decreases expression
EXP Fenitrothion promotes the reaction [Potassium Dichromate results in decreased expression of CAT protein]; Plant Extracts inhibits the reaction [Fenitrothion promotes the reaction [Potassium Dichromate results in decreased expression of CAT protein]]; Plant Extracts inhibits the reaction [Fenitrothion results in decreased expression of CAT protein]; Plant Extracts inhibits the reaction [Potassium Dichromate promotes the reaction [Fenitrothion results in decreased expression of CAT protein]]; Plant Preparations inhibits the reaction [Fenitrothion results in decreased activity of CAT protein]; Plant Preparations inhibits the reaction [Vehicle Emissions promotes the reaction [Fenitrothion results in decreased activity of CAT protein]]; Potassium Dichromate promotes the reaction [Fenitrothion results in decreased expression of CAT protein]; Quercetin inhibits the reaction [Fenitrothion results in decreased expression of CAT mRNA]; Vehicle Emissions promotes the reaction [Fenitrothion results in decreased activity of CAT protein]
Fenitrothion results in decreased expression of CAT mRNA; Fenitrothion results in decreased expression of CAT protein
CTD PMID:26264430, PMID:30578656, PMID:32572764 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Cd68 Cd68 molecule increases expression
multiple interactions
EXP Fenitrothion results in increased expression of CD68 protein
[Fenitrothion co-treated with Potassium Dichromate] results in increased expression of CD68 protein; Plant Extracts inhibits the reaction [[Fenitrothion co-treated with Potassium Dichromate] results in increased expression of CD68 protein]; Plant Extracts inhibits the reaction [Fenitrothion results in increased expression of CD68 protein]
CTD PMID:30578656 NCBI chr10:56,268,726...56,270,605
Ensembl chr10:56,268,720...56,270,640
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases activity
increases expression
ISO Fenitrothion results in decreased activity of CYP1A1 protein
Fenitrothion results in increased expression of CYP1A1 mRNA
CTD PMID:15620088, PMID:20183062, PMID:21298709 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression
decreases activity
ISO Fenitrothion results in increased expression of CYP1A2 mRNA
Fenitrothion results in decreased activity of CYP1A2 protein
CTD PMID:20183062, PMID:22310298, PMID:22634058 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases expression
decreases activity
multiple interactions
ISO Fenitrothion results in increased expression of CYP2B6 mRNA
Fenitrothion results in decreased activity of CYP2B6 protein
Fenitrothion inhibits the reaction [CYP2B6 protein results in increased hydroxylation of Bupropion]
CTD PMID:20183062, PMID:22310298, PMID:22634058 NCBI chr 1:83,163,103...83,236,615
Ensembl chr 1:83,163,079...83,236,615
JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 decreases activity ISO Fenitrothion results in decreased activity of CYP2C8 protein CTD PMID:20183062 NCBI chr 1:147,236,480...147,307,988 JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions
decreases activity
ISO Fenitrothion inhibits the reaction [CYP2E1 protein results in increased hydroxylation of Chlorzoxazone]
Fenitrothion results in decreased activity of CYP2E1 protein
CTD PMID:22634058 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Faah fatty acid amide hydrolase decreases activity ISO Fenitrothion results in decreased activity of FAAH protein CTD PMID:24361246 NCBI chr 5:134,852,899...134,872,095
Ensembl chr 5:134,852,875...134,871,775
JBrowse link
G Faahl fatty-acid amide hydrolase-like decreases activity ISO Fenitrothion results in decreased activity of FAAH protein CTD PMID:24361246 NCBI chr 5:134,330,204...134,349,400
Ensembl chr 5:134,331,929...134,348,995
JBrowse link
G Fshb follicle stimulating hormone subunit beta multiple interactions
increases secretion
EXP Fenitrothion promotes the reaction [Potassium Dichromate results in increased secretion of FSHB protein]; Plant Extracts inhibits the reaction [Fenitrothion promotes the reaction [Potassium Dichromate results in increased secretion of FSHB protein]]; Plant Extracts inhibits the reaction [Fenitrothion results in increased secretion of FSHB protein]; Plant Extracts inhibits the reaction [Potassium Dichromate promotes the reaction [Fenitrothion results in increased secretion of FSHB protein]]; Potassium Dichromate promotes the reaction [Fenitrothion results in increased secretion of FSHB protein] CTD PMID:30578656 NCBI chr 3:98,088,321...98,092,131
Ensembl chr 3:98,088,324...98,092,131
JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions
decreases expression
EXP Fenitrothion promotes the reaction [Potassium Dichromate results in decreased expression of GSR protein]; Plant Extracts inhibits the reaction [Fenitrothion promotes the reaction [Potassium Dichromate results in decreased expression of GSR protein]]; Plant Extracts inhibits the reaction [Fenitrothion results in decreased expression of GSR protein]; Plant Extracts inhibits the reaction [Potassium Dichromate promotes the reaction [Fenitrothion results in decreased expression of GSR protein]]; Potassium Dichromate promotes the reaction [Fenitrothion results in decreased expression of GSR protein] CTD PMID:30578656 NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361
JBrowse link
G Hsd17b3 hydroxysteroid (17-beta) dehydrogenase 3 multiple interactions
decreases expression
EXP Quercetin inhibits the reaction [Fenitrothion results in decreased expression of HSD17B3 mRNA] CTD PMID:26264430 NCBI chr17:1,579,319...1,610,745
Ensembl chr17:1,579,319...1,610,745
JBrowse link
G Hsd3b2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 multiple interactions
decreases expression
EXP Quercetin inhibits the reaction [Fenitrothion results in decreased expression of HSD3B2 mRNA] CTD PMID:26264430 NCBI chr 2:200,712,895...200,722,429
Ensembl chr 2:202,341,422...202,350,929
JBrowse link
G Ifng interferon gamma decreases expression ISO Fenitrothion results in decreased expression of IFNG protein CTD PMID:12108020 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Il2 interleukin 2 decreases expression ISO Fenitrothion results in decreased expression of IL2 protein CTD PMID:12108020 NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854
JBrowse link
G Lcat lecithin cholesterol acyltransferase multiple interactions
decreases activity
ISO Fenitrothion inhibits the reaction [[LCAT protein results in increased metabolism of Lecithins] which results in increased chemical synthesis of Cholesterol Esters]
Fenitrothion results in decreased activity of LCAT protein
CTD PMID:4847537 NCBI chr19:37,913,333...37,916,799
Ensembl chr19:37,913,336...37,916,813
JBrowse link
G Lhb luteinizing hormone subunit beta decreases secretion
multiple interactions
EXP Fenitrothion results in decreased secretion of LHB protein
Quercetin inhibits the reaction [Fenitrothion results in decreased secretion of LHB protein]
CTD PMID:26264430 NCBI chr 1:101,409,992...101,413,725
Ensembl chr 1:101,410,019...101,413,724
JBrowse link
G Mgll monoglyceride lipase decreases activity ISO Fenitrothion analog results in decreased activity of MGLL protein CTD PMID:16449251 NCBI chr 4:120,671,436...120,773,458
Ensembl chr 4:120,671,489...120,771,088
JBrowse link
G Nceh1 neutral cholesterol ester hydrolase 1 decreases activity ISO Fenitrothion analog results in decreased activity of NCEH1 protein CTD PMID:16449251 NCBI chr 2:112,868,834...112,932,622
Ensembl chr 2:112,868,707...112,934,953
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO [N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide co-treated with pyrimethanil co-treated with Fenitrothion co-treated with triadimefon co-treated with quinoxyfen co-treated with penconazole] results in increased activity of NR1I2 protein CTD PMID:25028461 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
G Nr5a1 nuclear receptor subfamily 5, group A, member 1 decreases expression
multiple interactions
EXP Fenitrothion results in decreased expression of NR5A1 mRNA
Quercetin inhibits the reaction [Fenitrothion results in decreased expression of NR5A1 mRNA]
CTD PMID:26264430 NCBI chr 3:22,998,900...23,020,441
Ensembl chr 3:22,999,616...23,020,441
JBrowse link
G Pla2g3 phospholipase A2, group III decreases expression EXP Fenitrothion results in decreased expression of PLA2G3 protein CTD PMID:29292090 NCBI chr14:83,724,828...83,730,614
Ensembl chr14:83,724,933...83,730,614
JBrowse link
G Pon1 paraoxonase 1 multiple interactions
decreases expression
decreases activity
EXP Fenitrothion promotes the reaction [Vehicle Emissions results in decreased activity of PON1 protein]; Fenitrothion promotes the reaction [Vehicle Emissions results in decreased expression of PON1 mRNA]; Plant Preparations inhibits the reaction [Fenitrothion promotes the reaction [Vehicle Emissions results in decreased activity of PON1 protein]]; Plant Preparations inhibits the reaction [Fenitrothion promotes the reaction [Vehicle Emissions results in decreased expression of PON1 mRNA]]; Plant Preparations inhibits the reaction [Fenitrothion results in decreased activity of PON1 protein]; Plant Preparations inhibits the reaction [Fenitrothion results in decreased expression of PON1 mRNA]; Plant Preparations inhibits the reaction [Vehicle Emissions promotes the reaction [Fenitrothion results in decreased activity of PON1 protein]]; Plant Preparations inhibits the reaction [Vehicle Emissions promotes the reaction [Fenitrothion results in decreased expression of PON1 mRNA]]; Vehicle Emissions promotes the reaction [Fenitrothion results in decreased activity of PON1 protein]; Vehicle Emissions promotes the reaction [Fenitrothion results in decreased expression of PON1 mRNA] CTD PMID:32572764 NCBI chr 4:30,249,749...30,276,297
Ensembl chr 4:30,249,742...30,276,372
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Fenitrothion inhibits the reaction [SLC22A2 protein results in increased uptake of Tetraethylammonium] CTD PMID:23770354 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
JBrowse link
G Slc22a6 solute carrier family 22 member 6 multiple interactions ISO Fenitrothion inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid] CTD PMID:21561794 NCBI chr 1:224,824,809...224,833,284
Ensembl chr 1:224,824,799...224,833,259
JBrowse link
G Sod1 superoxide dismutase 1 decreases expression
multiple interactions
EXP Fenitrothion results in decreased expression of SOD1 mRNA
Quercetin inhibits the reaction [Fenitrothion results in decreased expression of SOD1 mRNA]
CTD PMID:26264430 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
JBrowse link
fenthion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase decreases activity ISO
EXP
Fenthion results in decreased activity of ACHE protein CTD PMID:1855619, PMID:14976351 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
JBrowse link
G Ar androgen receptor multiple interactions ISO Dihydrotestosterone inhibits the reaction [Fenthion results in increased activity of AR protein]; Fenthion inhibits the reaction [Metribolone results in increased activity of AR protein] CTD PMID:15064155, PMID:18324785 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Bche butyrylcholinesterase decreases activity ISO Fenthion results in decreased activity of BCHE protein CTD PMID:24052565 NCBI chr 2:171,104,476...171,196,186
Ensembl chr 2:171,100,140...171,196,395
JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 affects metabolic processing ISO CYP3A5 protein affects the metabolism of Fenthion CTD PMID:17110060 NCBI chr12:19,074,288...19,114,491
Ensembl chr12:19,074,583...19,114,399
JBrowse link
G Dio1 iodothyronine deiodinase 1 decreases activity ISO Fenthion results in decreased activity of DIO1 protein CTD PMID:29228274 NCBI chr 5:126,894,837...126,911,532
Ensembl chr 5:126,895,286...126,911,520
JBrowse link
G Esrrg estrogen-related receptor gamma increases activity ISO Fenthion results in increased activity of ESRRG protein CTD PMID:20143881 NCBI chr13:106,063,799...106,683,353
Ensembl chr13:106,463,368...106,683,436
JBrowse link
G Fmo1 flavin containing dimethylaniline monoxygenase 1 increases oxidation ISO FMO1 protein results in increased oxidation of Fenthion CTD PMID:14976351 NCBI chr13:80,712,885...80,745,095
Ensembl chr13:80,712,882...80,745,347
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression ISO Fenthion results in increased expression of FOS mRNA CTD PMID:21538558 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha increases expression ISO Fenthion results in increased expression of GADD45A mRNA CTD PMID:21538558 NCBI chr 4:97,782,512...97,784,814
Ensembl chr 4:97,782,512...97,784,842
JBrowse link
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 increases expression EXP Fenthion results in increased expression of HSP90AA1 mRNA alternative form CTD PMID:8792849 NCBI chr 6:135,107,262...135,112,793
Ensembl chr 6:135,107,271...135,112,775
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit increases expression ISO Fenthion results in increased expression of JUN mRNA CTD PMID:21538558 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor increases expression ISO Fenthion results in increased expression of MYC mRNA CTD PMID:21538558 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
JBrowse link
G Nr4a1 nuclear receptor subfamily 4, group A, member 1 increases expression ISO Fenthion results in increased expression of NR4A1 CTD PMID:21538558 NCBI chr 7:142,899,358...142,920,216
Ensembl chr 7:142,905,758...142,920,216
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma increases expression ISO Fenthion results in increased expression of PPARG mRNA CTD PMID:32473317 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Ppp1r15a protein phosphatase 1, regulatory subunit 15A increases expression ISO Fenthion results in increased expression of PPP1R15A mRNA CTD PMID:21538558 NCBI chr 1:101,511,899...101,515,043
Ensembl chr 1:101,511,901...101,514,974
JBrowse link
G Socs3 suppressor of cytokine signaling 3 increases expression ISO Fenthion results in increased expression of SOCS3 mRNA CTD PMID:21538558 NCBI chr10:106,973,863...106,976,969
Ensembl chr10:106,975,178...106,976,040
JBrowse link
G Tnfaip3 TNF alpha induced protein 3 increases expression ISO Fenthion results in increased expression of TNFAIP3 mRNA CTD PMID:21538558 NCBI chr 1:14,401,103...14,416,369
Ensembl chr 1:14,402,913...14,412,807
JBrowse link
m-cresol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Scn4a sodium voltage-gated channel alpha subunit 4 affects activity ISO 3-cresol affects the activity of SCN4A protein polymorphism CTD PMID:11282107 NCBI chr10:94,505,026...94,557,803
Ensembl chr10:94,505,026...94,557,764
JBrowse link
metolcarb term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Thrb thyroid hormone receptor beta affects binding ISO metolcarb binds to THRB protein CTD PMID:28973306 NCBI chr15:8,890,578...9,239,815
Ensembl chr15:8,890,578...9,086,282
JBrowse link
o-cresol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions
increases expression
EXP Sodium Selenite inhibits the reaction [2-cresol results in increased expression of AKT1 mRNA] CTD PMID:21705299 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Alb albumin affects binding ISO 2-cresol binds to ALB protein CTD PMID:11334365 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression
multiple interactions
EXP 2-cresol results in increased expression of BAX mRNA
Sodium Selenite inhibits the reaction [2-cresol results in increased expression of BAX mRNA]
CTD PMID:21705299 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bche butyrylcholinesterase multiple interactions ISO [2-(2-cresyl)-4H-1-3-2-benzodioxaphosphorin-2-oxide binds to and results in decreased activity of BCHE protein] which results in increased abundance of 2-cresol CTD PMID:22898212 NCBI chr 2:171,104,476...171,196,186
Ensembl chr 2:171,100,140...171,196,395
JBrowse link
G Bcl2 BCL2, apoptosis regulator increases expression
multiple interactions
EXP 2-cresol results in increased expression of BCL2 mRNA
Sodium Selenite inhibits the reaction [2-cresol results in increased expression of BCL2 mRNA]
CTD PMID:21705299 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Gabra1 gamma-aminobutyric acid type A receptor subunit alpha 1 multiple interactions EXP 2-cresol results in increased activity of [GABRG2 protein binds to GABRA1 protein binds to GABRB2 protein] CTD PMID:11399263 NCBI chr10:27,310,718...27,371,802
Ensembl chr10:27,310,725...27,366,665
JBrowse link
G Gabrb2 gamma-aminobutyric acid type A receptor subunit beta 2 multiple interactions EXP 2-cresol results in increased activity of [GABRG2 protein binds to GABRA1 protein binds to GABRB2 protein] CTD PMID:11399263 NCBI chr10:27,973,694...28,193,072
Ensembl chr10:27,973,681...28,187,565
JBrowse link
G Gabrg2 gamma-aminobutyric acid type A receptor subunit gamma 2 multiple interactions EXP 2-cresol results in increased activity of [GABRG2 protein binds to GABRA1 protein binds to GABRB2 protein] CTD PMID:11399263 NCBI chr10:27,090,913...27,179,786
Ensembl chr10:27,092,827...27,179,900
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma increases expression
multiple interactions
EXP 2-cresol results in increased expression of PPARG mRNA
Sodium Selenite inhibits the reaction [2-cresol results in increased expression of PPARG mRNA]
CTD PMID:21705299 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Prkca protein kinase C, alpha increases expression
multiple interactions
EXP 2-cresol results in increased expression of PRKCA mRNA
Sodium Selenite inhibits the reaction [2-cresol results in increased expression of PRKCA mRNA]
CTD PMID:21705299 NCBI chr10:96,186,509...96,585,168
Ensembl chr10:96,191,133...96,584,947
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression
multiple interactions
EXP 2-cresol results in increased expression of PTGS2 mRNA
Sodium Selenite inhibits the reaction [2-cresol results in increased expression of PTGS2 mRNA]
CTD PMID:21705299 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
orcinol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases activity ISO orcinol results in decreased activity of CYP1A1 protein CTD PMID:24667653 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
p-cresol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alb albumin affects binding ISO 4-cresol binds to ALB protein CTD PMID:11334365 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
JBrowse link
G Becn1 beclin 1 increases expression ISO
EXP
4-cresol results in increased expression of BECN1 protein CTD PMID:25668154 NCBI chr10:89,209,944...89,225,297
Ensembl chr10:89,209,940...89,225,297
JBrowse link
G Casp3 caspase 3 increases activity ISO 4-cresol results in increased activity of CASP3 protein CTD PMID:25668154 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp8 caspase 8 multiple interactions
increases cleavage
ISO SQSTM1 mutant form inhibits the reaction [4-cresol results in increased cleavage of CASP8 protein] CTD PMID:25668154 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Cdh2 cadherin 2 multiple interactions
affects localization
EXP 4-cresol inhibits the reaction [CTNND1 protein binds to CDH2 protein]; Go 6976 inhibits the reaction [4-cresol affects the localization of CDH2 protein]; Go 6976 inhibits the reaction [4-cresol inhibits the reaction [CTNND1 protein binds to CDH2 protein]] CTD PMID:23466501 NCBI chr18:8,146,971...8,366,037
Ensembl chr18:8,146,971...8,360,684
JBrowse link
G Ctnnd1 catenin delta 1 multiple interactions EXP 4-cresol affects the localization of and results in decreased phosphorylation of CTNND1 protein; 4-cresol inhibits the reaction [CTNND1 protein binds to CDH2 protein]; Go 6976 inhibits the reaction [4-cresol affects the localization of and results in decreased phosphorylation of CTNND1 protein]; Go 6976 inhibits the reaction [4-cresol inhibits the reaction [CTNND1 protein binds to CDH2 protein]]; PRKCA mutant form inhibits the reaction [4-cresol affects the localization of and results in decreased phosphorylation of CTNND1 protein] CTD PMID:23466501 NCBI chr 3:72,001,904...72,053,047
Ensembl chr 3:72,002,152...72,053,049
JBrowse link
G Cx3cl1 C-X3-C motif chemokine ligand 1 multiple interactions ISO 4-cresol inhibits the reaction [IL1B protein results in increased expression of CX3CL1 protein] CTD PMID:16954166 NCBI chr19:10,644,267...10,654,861
Ensembl chr19:10,644,244...10,653,800
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases metabolic processing ISO CYP1A2 protein results in increased metabolism of 4-cresol CTD PMID:16174805 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 increases metabolic processing ISO CYP2D6 protein results in increased metabolism of 4-cresol CTD PMID:16174805 NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 increases metabolic processing ISO CYP2E1 protein results in increased metabolism of 4-cresol CTD PMID:16174805 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G F11r F11 receptor decreases expression ISO 4-cresol results in decreased expression of F11R protein CTD PMID:16954166 NCBI chr13:89,826,272...89,850,151
Ensembl chr13:89,826,254...89,850,612
JBrowse link
G Gja1 gap junction protein, alpha 1 multiple interactions
decreases phosphorylation
EXP 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [4-cresol results in decreased phosphorylation of GJA1 protein]; PRKCA mutant form inhibits the reaction [4-cresol results in decreased phosphorylation of GJA1 protein] CTD PMID:22813906 NCBI chr20:37,876,650...37,889,097
Ensembl chr20:37,876,650...37,889,089
JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO 4-cresol results in increased expression of HMOX1 mRNA CTD PMID:29214717 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO 4-cresol inhibits the reaction [IL1B protein results in increased expression of ICAM1 mRNA]; 4-cresol inhibits the reaction [IL1B protein results in increased expression of ICAM1 protein]; 4-cresol inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]; 4-cresol inhibits the reaction [TNF protein results in increased expression of ICAM1 protein] CTD PMID:12427124 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO 4-cresol inhibits the reaction [IL1B protein results in increased expression of CX3CL1 protein]; 4-cresol inhibits the reaction [IL1B protein results in increased expression of ICAM1 mRNA]; 4-cresol inhibits the reaction [IL1B protein results in increased expression of ICAM1 protein]; 4-cresol inhibits the reaction [IL1B protein results in increased expression of VCAM1 mRNA]; 4-cresol inhibits the reaction [IL1B protein results in increased expression of VCAM1 protein] CTD PMID:12427124, PMID:16954166 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit increases phosphorylation ISO 4-cresol results in increased phosphorylation of JUN protein CTD PMID:25668154 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Mir139 microRNA 139 increases expression ISO 4-cresol results in increased expression of MIR139 mRNA CTD PMID:32105654 NCBI chr 1:166,589,545...166,589,612
Ensembl chr 1:166,589,545...166,589,612
JBrowse link
G Mir144 microRNA 144 decreases expression ISO 4-cresol results in decreased expression of MIR144 mRNA CTD PMID:32105654 NCBI chr10:65,291,365...65,291,447
Ensembl chr10:65,291,365...65,291,447
JBrowse link
G Mir186 microRNA 186 increases expression ISO 4-cresol results in increased expression of MIR186 mRNA CTD PMID:32105654 NCBI chr 2:263,873,759...263,873,844
Ensembl chr 2:263,873,759...263,873,844
JBrowse link
G Mir188 microRNA 188 increases expression ISO 4-cresol results in increased expression of MIR188 mRNA CTD PMID:32105654 NCBI chr  X:16,110,270...16,110,349
Ensembl chr  X:16,110,270...16,110,349
JBrowse link
G Mir190b microRNA 190b increases expression ISO 4-cresol results in increased expression of MIR190B mRNA CTD PMID:32105654 NCBI chr 2:189,421,137...189,421,214
Ensembl chr 2:189,421,137...189,421,214
JBrowse link
G Mir196b microRNA 196b decreases expression ISO 4-cresol results in decreased expression of MIR196B mRNA CTD PMID:32105654 NCBI chr 4:82,199,056...82,199,140
Ensembl chr 4:82,199,056...82,199,140
JBrowse link
G Mir196c microRNA 196c decreases expression ISO 4-cresol results in decreased expression of MIR196A-1 mRNA CTD PMID:32105654 NCBI chr10:84,113,578...84,113,657
Ensembl chr10:84,113,578...84,113,657
JBrowse link
G Mir200b microRNA 200b decreases expression ISO 4-cresol results in decreased expression of MIR200B mRNA CTD PMID:32105654 NCBI chr 5:173,490,144...173,490,238
Ensembl chr 5:173,490,144...173,490,238
JBrowse link
G Mir204 microRNA 204 increases expression ISO 4-cresol results in increased expression of MIR204 mRNA CTD PMID:32105654 NCBI chr 1:240,403,000...240,403,109
Ensembl chr 1:240,403,000...240,403,109
JBrowse link
G Mir20a microRNA 20a increases expression ISO 4-cresol results in increased expression of MIR20A mRNA CTD PMID:32105654 NCBI chr15:100,180,334...100,180,418
Ensembl chr15:100,180,334...100,180,418
JBrowse link
G Mir324 microRNA 324 increases expression ISO 4-cresol results in increased expression of MIR324 mRNA CTD PMID:32105654 NCBI chr10:56,621,126...56,621,208
Ensembl chr10:56,621,124...56,621,212
JBrowse link
G Mir331 microRNA 331 increases expression ISO 4-cresol results in increased expression of MIR331 mRNA CTD PMID:32105654 NCBI chr 7:34,881,095...34,881,190
Ensembl chr 7:34,881,095...34,881,190
JBrowse link
G Mir410 microRNA 410 increases expression ISO 4-cresol results in increased expression of MIR410 mRNA CTD PMID:32105654 NCBI chr 6:133,893,997...133,894,072
Ensembl chr 6:133,893,993...133,894,073
JBrowse link
G Mir488 microRNA 488 increases expression ISO 4-cresol results in increased expression of MIR488 mRNA CTD PMID:32105654 NCBI chr13:76,198,593...76,198,671
Ensembl chr13:76,198,593...76,198,671
JBrowse link
G Mir494 microRNA 494 increases expression ISO 4-cresol results in increased expression of MIR494 mRNA CTD PMID:32105654 NCBI chr 6:133,864,370...133,864,452
Ensembl chr 6:133,864,369...133,864,453
JBrowse link
G Mir541 microRNA 541 increases expression ISO 4-cresol results in increased expression of MIR541 mRNA CTD PMID:32105654 NCBI chr 6:133,892,655...133,892,744
Ensembl chr 6:133,892,655...133,892,744
JBrowse link
G Mir542 microRNA 542 decreases expression ISO 4-cresol results in decreased expression of MIR542 mRNA CTD PMID:32105654 NCBI chr  X:158,152,146...158,152,224
Ensembl chr  X:158,152,146...158,152,224
JBrowse link
G Mir877 microRNA 877 increases expression ISO 4-cresol results in increased expression of MIR877 mRNA CTD PMID:32105654 NCBI chr20:3,318,872...3,318,956
Ensembl chr20:3,318,872...3,318,956
JBrowse link
G Mmp2 matrix metallopeptidase 2 increases activity ISO 4-cresol results in increased activity of MMP2 protein CTD PMID:30910523 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO 4-cresol results in increased expression of and results in increased activity of MMP9 protein; Everolimus inhibits the reaction [4-cresol results in increased expression of MMP9 protein]; Y 27632 inhibits the reaction [4-cresol results in increased expression of MMP9 protein] CTD PMID:30910523 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions
increases phosphorylation
ISO [Everolimus co-treated with Y 27632] inhibits the reaction [4-cresol results in increased phosphorylation of MTOR protein]; Everolimus inhibits the reaction [4-cresol results in increased phosphorylation of MTOR protein]; Y 27632 inhibits the reaction [4-cresol results in increased phosphorylation of MTOR protein] CTD PMID:30910523 NCBI chr 5:165,263,813...165,373,967
Ensembl chr 5:165,263,800...165,373,967
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 increases expression ISO 4-cresol results in increased expression of NFE2L2 mRNA CTD PMID:29214717 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression ISO 4-cresol results in increased expression of NQO1 mRNA CTD PMID:29214717 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Prkca protein kinase C, alpha increases phosphorylation
increases response to substance
multiple interactions
EXP 4-cresol results in increased phosphorylation of PRKCA protein
PRKCA protein results in increased susceptibility to 4-cresol
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [4-cresol results in increased phosphorylation of PRKCA protein]; 4-cresol results in increased phosphorylation of and results in increased activity of PRKCA protein; PRKCA mutant form inhibits the reaction [4-cresol affects the localization of and results in decreased phosphorylation of CTNND1 protein]; PRKCA mutant form inhibits the reaction [4-cresol results in decreased phosphorylation of GJA1 protein]
CTD PMID:22813906, PMID:23466501 NCBI chr10:96,186,509...96,585,168
Ensembl chr10:96,191,133...96,584,947
JBrowse link
G Rhoa ras homolog family member A increases expression
multiple interactions
ISO 4-cresol results in increased expression of RHOA protein
[Everolimus co-treated with Y 27632] inhibits the reaction [4-cresol results in increased expression of RHOA protein]; Y 27632 inhibits the reaction [4-cresol results in increased expression of RHOA protein]
CTD PMID:30910523 NCBI chr 8:117,082,440...117,116,244
Ensembl chr 8:117,106,576...117,116,167
JBrowse link
G Snora58 small nucleolar RNA, H/ACA box 58 decreases expression ISO 4-cresol results in decreased expression of MIR3068 mRNA CTD PMID:32105654 NCBI chr 6:111,468,732...111,468,807
Ensembl chr 6:111,468,732...111,468,807
JBrowse link
G Sqstm1 sequestosome 1 multiple interactions
increases expression
ISO SQSTM1 mutant form inhibits the reaction [4-cresol results in increased cleavage of CASP8 protein]
4-cresol results in increased expression of SQSTM1 protein
CTD PMID:25668154 NCBI chr10:35,704,728...35,716,316
Ensembl chr10:35,704,730...35,716,294
JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 increases metabolic processing EXP SULT1A1 protein results in increased metabolism of 4-cresol CTD PMID:11301044 NCBI chr 1:198,100,586...198,104,106
Ensembl chr 1:198,100,586...198,104,109
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO 4-cresol inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]; 4-cresol inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; 4-cresol inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]; 4-cresol inhibits the reaction [TNF protein results in increased expression of VCAM1 protein] CTD PMID:12427124 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 multiple interactions
increases glucuronidation
ISO Acetaminophen inhibits the reaction [UGT1A6 protein results in increased glucuronidation of 4-cresol]; amentoflavone inhibits the reaction [UGT1A6 protein results in increased glucuronidation of 4-cresol] CTD PMID:32421801 NCBI chr 9:95,241,609...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 multiple interactions
increases glucuronidation
ISO 4-cresol inhibits the reaction [[UGT1A9 protein results in increased glucuronidation of Mycophenolic Acid] which results in increased abundance of mycophenolic acid glucuronide]; [4-cresol inhibits the reaction [[UGT1A9 protein results in increased glucuronidation of Mycophenolic Acid] which results in increased abundance of mycophenolic acid glucuronide]] which results in increased abundance of Mycophenolic Acid; Niflumic Acid inhibits the reaction [UGT1A9 protein results in increased glucuronidation of 4-cresol] CTD PMID:31742356, PMID:32421801 NCBI chr 9:95,161,157...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt2b17 UDP glucuronosyltransferase family 2 member B17 increases glucuronidation EXP UGT2B1 protein results in increased glucuronidation of 4-cresol CTD PMID:8302279 NCBI chr14:22,724,399...22,736,148
Ensembl chr14:22,724,070...22,825,444
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO 4-cresol inhibits the reaction [IL1B protein results in increased expression of VCAM1 mRNA]; 4-cresol inhibits the reaction [IL1B protein results in increased expression of VCAM1 protein]; 4-cresol inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]; 4-cresol inhibits the reaction [TNF protein results in increased expression of VCAM1 protein] CTD PMID:12427124 NCBI chr 2:219,071,193...219,090,931
Ensembl chr 2:219,071,193...219,097,619
JBrowse link
tolterodine tartrate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb4 ATP binding cassette subfamily B member 4 decreases activity ISO Tolterodine Tartrate results in decreased activity of ABCB4 protein CTD PMID:28437613 NCBI chr 4:22,133,984...22,192,687
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Ahr aryl hydrocarbon receptor decreases expression ISO Tolterodine Tartrate results in decreased expression of AHR mRNA CTD PMID:24316275 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Chrm2 cholinergic receptor, muscarinic 2 multiple interactions ISO Tolterodine Tartrate binds to and results in decreased activity of CHRM2 protein CTD PMID:15140916 NCBI chr 4:64,089,028...64,091,090
Ensembl chr 4:64,088,900...64,091,090
JBrowse link
G Chrm3 cholinergic receptor, muscarinic 3 multiple interactions ISO Tolterodine Tartrate binds to and results in decreased activity of CHRM3 protein CTD PMID:15140916 NCBI chr17:63,990,599...64,463,222
Ensembl chr17:63,990,599...63,994,169
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 increases metabolic processing
affects metabolic processing
multiple interactions
ISO CYP2D6 protein results in increased metabolism of Tolterodine Tartrate
CYP2D6 polymorphism affects the metabolism of Tolterodine Tartrate
Fluoxetine inhibits the reaction [CYP2D6 protein results in increased metabolism of Tolterodine Tartrate]
CTD PMID:10583026, PMID:28087463 NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 multiple interactions
decreases expression
ISO Tolterodine Tartrate inhibits the reaction [Dexamethasone results in increased expression of NR3C1 mRNA]
Tolterodine Tartrate results in decreased expression of NR3C1 mRNA
CTD PMID:24316275 NCBI chr18:31,728,373...32,704,022
Ensembl chr18:31,728,373...31,749,647
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Tolterodine Tartrate inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    chemical entity 19785
      molecular entity 19782
        polyatomic entity 19695
          heteroatomic molecular entity 19620
            hydroxides 19066
              organic hydroxy compound 18630
                phenols 18109
                  hydroxytoluene 112
                    1,2-dihydroheudelotinol 0
                    10-acetoxy-8-hydroxy-9-O-angeloylthmol 0
                    2,4-Dimethylphenol 2
                    2-Chloro-4-methylphenol 0
                    3,17-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9-one 0
                    4,6-dinitro-o-cresol 0
                    4-chloro-m-cresol 5
                    4-methyl-2-[(5-methyl-2-thiophenyl)methylideneamino]phenol 0
                    LSM-27175 0
                    cresol + 108
                    dihydroxytoluene + 1
                    tribromometacresol 0
                    trihydroxytoluene + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    p-block element atom 19670
                      carbon group element atom 19572
                        carbon atom 19561
                          organic molecular entity 19561
                            organic molecule 19486
                              organic cyclic compound 19282
                                carbocyclic compound 18181
                                  benzenoid aromatic compound 17178
                                    benzenes 16920
                                      toluenes 6223
                                        hydroxytoluene 112
                                          1,2-dihydroheudelotinol 0
                                          10-acetoxy-8-hydroxy-9-O-angeloylthmol 0
                                          2,4-Dimethylphenol 2
                                          2-Chloro-4-methylphenol 0
                                          3,17-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9-one 0
                                          4,6-dinitro-o-cresol 0
                                          4-chloro-m-cresol 5
                                          4-methyl-2-[(5-methyl-2-thiophenyl)methylideneamino]phenol 0
                                          LSM-27175 0
                                          cresol + 108
                                          dihydroxytoluene + 1
                                          tribromometacresol 0
                                          trihydroxytoluene + 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.