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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:hydroxypyridine
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Accession:CHEBI:24745 term browser browse the term
Definition:Any member of the class of pyridines with at least one hydroxy substituent.
Synonyms:related_synonym: hydroxypyridines



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2-amino-3-hydroxypyridine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FOS Fos proto-oncogene, AP-1 transcription factor subunit increases expression EXP 2-amino-3-hydroxypyridine results in increased expression of FOS mRNA CTD PMID:31967339 NCBI chr14:75,278,828...75,282,230
Ensembl chr14:75,278,826...75,282,230
JBrowse link
G NFE2L2 NFE2 like bZIP transcription factor 2 decreases expression EXP 2-amino-3-hydroxypyridine results in decreased expression of NFE2L2 mRNA CTD PMID:31967339 NCBI chr 2:177,230,303...177,264,727
Ensembl chr 2:177,218,667...177,392,756
JBrowse link
3,5,6-trichloro-2-pyridinol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACHE acetylcholinesterase (Yt blood group) increases expression
decreases activity
ISO
EXP
3,5,6-trichloro-2-pyridinol results in increased expression of ACHE mRNA
3,5,6-trichloro-2-pyridinol results in decreased activity of ACHE protein
CTD PMID:21224175 PMID:23220036 NCBI chr 7:100,889,994...100,896,994
Ensembl chr 7:100,889,994...100,896,974
JBrowse link
G AFP alpha fetoprotein increases expression
affects expression
ISO 3,5,6-trichloro-2-pyridinol results in increased expression of AFP mRNA
3,5,6-trichloro-2-pyridinol affects the expression of AFP mRNA
CTD PMID:23220036 PMID:25137620 NCBI chr 4:73,436,221...73,456,174
Ensembl chr 4:73,431,138...73,456,174
JBrowse link
G AR androgen receptor decreases expression
affects binding
ISO
EXP
3,5,6-trichloro-2-pyridinol results in decreased expression of AR protein
3,5,6-trichloro-2-pyridinol binds to AR protein
CTD PMID:34352351 NCBI chr  X:67,544,021...67,730,619
Ensembl chr  X:67,544,021...67,730,619
JBrowse link
G BCHE butyrylcholinesterase decreases activity EXP 3,5,6-trichloro-2-pyridinol results in decreased activity of BCHE protein CTD PMID:21224175 NCBI chr 3:165,772,904...165,837,423
Ensembl chr 3:165,772,904...165,837,462
JBrowse link
G CEBPA CCAAT enhancer binding protein alpha multiple interactions ISO 3,5,6-trichloro-2-pyridinol promotes the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of CEBPA mRNA]; 3,5,6-trichloro-2-pyridinol promotes the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of CEBPA protein] CTD PMID:32017950 NCBI chr19:33,299,934...33,302,534
Ensembl chr19:33,299,934...33,302,534
JBrowse link
G CREB1 cAMP responsive element binding protein 1 decreases phosphorylation ISO 3,5,6-trichloro-2-pyridinol results in decreased phosphorylation of CREB1 protein CTD PMID:34352351 NCBI chr 2:207,529,962...207,605,988
Ensembl chr 2:207,529,737...207,605,988
JBrowse link
G CRH corticotropin releasing hormone multiple interactions ISO [diethyl phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with diisodecyl phthalate co-treated with bis(2-propylheptyl)phthalate co-treated with bisphenol A co-treated with 3,5,6-trichloro-2-pyridinol co-treated with 3-phenoxybenzoic acid co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of CRH mRNA CTD PMID:32518293 NCBI chr 8:66,176,376...66,178,464
Ensembl chr 8:66,176,376...66,178,464
JBrowse link
G CRHR1 corticotropin releasing hormone receptor 1 multiple interactions ISO [diethyl phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with diisodecyl phthalate co-treated with bis(2-propylheptyl)phthalate co-treated with bisphenol A co-treated with 3,5,6-trichloro-2-pyridinol co-treated with 3-phenoxybenzoic acid co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of CRHR1 mRNA CTD PMID:32518293 NCBI chr17:45,784,320...45,835,828
Ensembl chr17:45,784,277...45,835,828
JBrowse link
G CYP11A1 cytochrome P450 family 11 subfamily A member 1 multiple interactions ISO [diethyl phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with diisodecyl phthalate co-treated with bis(2-propylheptyl)phthalate co-treated with bisphenol A co-treated with 3,5,6-trichloro-2-pyridinol co-treated with 3-phenoxybenzoic acid co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of CYP11A1 mRNA CTD PMID:32518293 NCBI chr15:74,337,762...74,367,646
Ensembl chr15:74,337,759...74,367,646
JBrowse link
G CYP2C19 cytochrome P450 family 2 subfamily C member 19 increases chemical synthesis EXP CYP2C19 protein results in increased chemical synthesis of 3,5,6-trichloro-2-pyridinol CTD PMID:22281205 NCBI chr10:94,762,681...94,855,547
Ensembl chr10:94,762,681...94,855,547
JBrowse link
G CYP3A4 cytochrome P450 family 3 subfamily A member 4 increases chemical synthesis EXP CYP3A4 results in increased chemical synthesis of 3,5,6-trichloro-2-pyridinol CTD PMID:20709133 NCBI chr 7:99,756,967...99,784,184
Ensembl chr 7:99,756,960...99,784,248
JBrowse link
G ESR2 estrogen receptor 2 multiple interactions ISO [diethyl phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with diisodecyl phthalate co-treated with bis(2-propylheptyl)phthalate co-treated with bisphenol A co-treated with 3,5,6-trichloro-2-pyridinol co-treated with 3-phenoxybenzoic acid co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of ESR2 mRNA CTD PMID:32518293 NCBI chr14:64,226,707...64,338,613
Ensembl chr14:64,084,232...64,338,112
JBrowse link
G FABP4 fatty acid binding protein 4 multiple interactions ISO 3,5,6-trichloro-2-pyridinol promotes the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of FABP4 mRNA]; 3,5,6-trichloro-2-pyridinol promotes the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of FABP4 protein] CTD PMID:32017950 NCBI chr 8:81,478,419...81,483,233
Ensembl chr 8:81,478,419...81,483,236
JBrowse link
G FKBP5 FKBP prolyl isomerase 5 multiple interactions ISO [diethyl phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with diisodecyl phthalate co-treated with bis(2-propylheptyl)phthalate co-treated with bisphenol A co-treated with 3,5,6-trichloro-2-pyridinol co-treated with 3-phenoxybenzoic acid co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of FKBP5 mRNA CTD PMID:32518293 NCBI chr 6:35,573,590...35,728,583
Ensembl chr 6:35,573,585...35,728,583
JBrowse link
G GRIN2B glutamate ionotropic receptor NMDA type subunit 2B multiple interactions ISO [diethyl phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with diisodecyl phthalate co-treated with bis(2-propylheptyl)phthalate co-treated with bisphenol A co-treated with 3,5,6-trichloro-2-pyridinol co-treated with 3-phenoxybenzoic acid co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of GRIN2B mRNA CTD PMID:32518293 NCBI chr12:13,537,337...13,982,134
Ensembl chr12:13,437,942...13,982,002
JBrowse link
G HTR1A 5-hydroxytryptamine receptor 1A multiple interactions ISO [diethyl phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with diisodecyl phthalate co-treated with bis(2-propylheptyl)phthalate co-treated with bisphenol A co-treated with 3,5,6-trichloro-2-pyridinol co-treated with 3-phenoxybenzoic acid co-treated with Dichlorodiphenyl Dichloroethylene] affects the expression of HTR1A mRNA CTD PMID:32518293 NCBI chr 5:63,957,874...63,962,445
Ensembl chr 5:63,957,874...63,962,507
JBrowse link
G HTR2A 5-hydroxytryptamine receptor 2A multiple interactions ISO [diethyl phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with diisodecyl phthalate co-treated with bis(2-propylheptyl)phthalate co-treated with bisphenol A co-treated with 3,5,6-trichloro-2-pyridinol co-treated with 3-phenoxybenzoic acid co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of HTR2A mRNA CTD PMID:32518293 NCBI chr13:46,831,546...46,898,082
Ensembl chr13:46,831,546...46,897,076
JBrowse link
G INS-IGF2 INS-IGF2 readthrough multiple interactions ISO 3,5,6-trichloro-2-pyridinol promotes the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of CEBPA mRNA]; 3,5,6-trichloro-2-pyridinol promotes the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of CEBPA protein]; 3,5,6-trichloro-2-pyridinol promotes the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of FABP4 mRNA]; 3,5,6-trichloro-2-pyridinol promotes the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of FABP4 protein]; 3,5,6-trichloro-2-pyridinol promotes the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of PPARG mRNA]; [3,5,6-trichloro-2-pyridinol co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of PPARG protein CTD PMID:32017950 NCBI chr11:2,129,117...2,161,209
Ensembl chr11:2,132,538...2,161,209
JBrowse link
G KDR kinase insert domain receptor increases expression ISO 3,5,6-trichloro-2-pyridinol results in increased expression of KDR mRNA CTD PMID:23220036 PMID:25137620 NCBI chr 4:55,078,481...55,125,595
Ensembl chr 4:55,078,481...55,125,595
JBrowse link
G MC2R melanocortin 2 receptor multiple interactions ISO [diethyl phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with diisodecyl phthalate co-treated with bis(2-propylheptyl)phthalate co-treated with bisphenol A co-treated with 3,5,6-trichloro-2-pyridinol co-treated with 3-phenoxybenzoic acid co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of MC2R mRNA CTD PMID:32518293 NCBI chr18:13,882,044...13,915,707
Ensembl chr18:13,882,044...13,915,707
JBrowse link
G MYH6 myosin heavy chain 6 increases expression ISO 3,5,6-trichloro-2-pyridinol results in increased expression of MYH6 mRNA CTD PMID:23220036 NCBI chr14:23,381,987...23,408,273
Ensembl chr14:23,381,982...23,408,273
JBrowse link
G NANOG Nanog homeobox decreases expression ISO 3,5,6-trichloro-2-pyridinol results in decreased expression of NANOG mRNA CTD PMID:23220036 NCBI chr12:7,789,402...7,799,146
Ensembl chr12:7,787,794...7,799,146
JBrowse link
G NEFM neurofilament medium chain increases expression
decreases expression
ISO 3,5,6-trichloro-2-pyridinol results in increased expression of NEFM mRNA
3,5,6-trichloro-2-pyridinol results in decreased expression of NEFM mRNA
CTD PMID:23220036 PMID:25137620 NCBI chr 8:24,913,761...24,919,093
Ensembl chr 8:24,913,758...24,919,098
JBrowse link
G NES nestin affects expression
decreases expression
increases expression
ISO 3,5,6-trichloro-2-pyridinol affects the expression of NES mRNA
3,5,6-trichloro-2-pyridinol results in decreased expression of NES mRNA
3,5,6-trichloro-2-pyridinol results in increased expression of NES mRNA
CTD PMID:23220036 PMID:25137620 NCBI chr 1:156,668,763...156,677,407
Ensembl chr 1:156,668,763...156,677,407
JBrowse link
G NR3C1 nuclear receptor subfamily 3 group C member 1 multiple interactions ISO [diethyl phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with diisodecyl phthalate co-treated with bis(2-propylheptyl)phthalate co-treated with bisphenol A co-treated with 3,5,6-trichloro-2-pyridinol co-treated with 3-phenoxybenzoic acid co-treated with Dichlorodiphenyl Dichloroethylene] affects the expression of NR3C1 mRNA CTD PMID:32518293 NCBI chr 5:143,277,931...143,435,512
Ensembl chr 5:143,277,931...143,435,512
JBrowse link
G NR3C2 nuclear receptor subfamily 3 group C member 2 multiple interactions ISO [diethyl phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with diisodecyl phthalate co-treated with bis(2-propylheptyl)phthalate co-treated with bisphenol A co-treated with 3,5,6-trichloro-2-pyridinol co-treated with 3-phenoxybenzoic acid co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of NR3C2 mRNA CTD PMID:32518293 NCBI chr 4:148,078,764...148,445,508
Ensembl chr 4:148,078,762...148,444,698
JBrowse link
G OXT oxytocin/neurophysin I prepropeptide multiple interactions ISO [diethyl phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with diisodecyl phthalate co-treated with bis(2-propylheptyl)phthalate co-treated with bisphenol A co-treated with 3,5,6-trichloro-2-pyridinol co-treated with 3-phenoxybenzoic acid co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of OXT mRNA CTD PMID:32518293 NCBI chr20:3,071,620...3,072,517
Ensembl chr20:3,071,620...3,072,517
JBrowse link
G OXTR oxytocin receptor multiple interactions ISO [diethyl phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with diisodecyl phthalate co-treated with bis(2-propylheptyl)phthalate co-treated with bisphenol A co-treated with 3,5,6-trichloro-2-pyridinol co-treated with 3-phenoxybenzoic acid co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of OXTR mRNA CTD PMID:32518293 NCBI chr 3:8,741,269...8,769,613
Ensembl chr 3:8,750,381...8,769,628
JBrowse link
G PNPLA6 patatin like phospholipase domain containing 6 decreases activity
decreases expression
increases expression
ISO 3,5,6-trichloro-2-pyridinol results in decreased activity of PNPLA6 protein
3,5,6-trichloro-2-pyridinol results in decreased expression of PNPLA6 mRNA
3,5,6-trichloro-2-pyridinol results in increased expression of PNPLA6 mRNA
CTD PMID:23220036 PMID:25137620 NCBI chr19:7,534,164...7,561,767
Ensembl chr19:7,534,004...7,561,764
JBrowse link
G POU5F1 POU class 5 homeobox 1 increases expression ISO 3,5,6-trichloro-2-pyridinol results in increased expression of POU5F1 mRNA CTD PMID:23220036 NCBI chr 6:31,164,337...31,170,682
Ensembl chr 6:31,164,337...31,180,731
JBrowse link
G PPARG peroxisome proliferator activated receptor gamma multiple interactions ISO 3,5,6-trichloro-2-pyridinol promotes the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of PPARG mRNA]; [3,5,6-trichloro-2-pyridinol co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of PPARG protein CTD PMID:32017950 NCBI chr 3:12,287,368...12,434,344
Ensembl chr 3:12,287,368...12,434,356
JBrowse link
3-hydroxypicolinic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MMP1 matrix metallopeptidase 1 decreases activity EXP 3-hydroxypicolinic acid results in decreased activity of MMP1 protein CTD PMID:21189019 NCBI chr11:102,789,919...102,798,160
Ensembl chr11:102,789,401...102,798,160
JBrowse link
G MMP2 matrix metallopeptidase 2 decreases activity EXP 3-hydroxypicolinic acid results in decreased activity of MMP2 protein CTD PMID:21189019 NCBI chr16:55,478,830...55,506,691
Ensembl chr16:55,389,700...55,506,691
JBrowse link
G MMP3 matrix metallopeptidase 3 decreases activity EXP 3-hydroxypicolinic acid results in decreased activity of MMP3 protein CTD PMID:21189019 NCBI chr11:102,835,801...102,843,609
Ensembl chr11:102,835,801...102,843,609
JBrowse link
G MMP8 matrix metallopeptidase 8 decreases activity EXP 3-hydroxypicolinic acid results in decreased activity of MMP8 protein CTD PMID:21189019 NCBI chr11:102,711,796...102,724,954
Ensembl chr11:102,711,796...102,727,050
JBrowse link
4-pyridoxic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G COL2A1 collagen type II alpha 1 chain multiple interactions ISO [COL2A1 protein co-treated with Freund's Adjuvant] results in decreased abundance of Pyridoxic Acid CTD PMID:24709313 NCBI chr12:47,972,967...48,006,212
Ensembl chr12:47,972,967...48,004,554
JBrowse link
5'-phosphopyridoxal-6-azobenzene-2,4-disulfonic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AVP arginine vasopressin multiple interactions ISO pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [[Phenylephrine co-treated with Adenosine Triphosphate] results in increased secretion of AVP protein]; pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [Adenosine Triphosphate results in increased secretion of AVP protein] CTD PMID:11102496 NCBI chr20:3,082,556...3,084,724
Ensembl chr20:3,082,556...3,084,724
JBrowse link
G FN1 fibronectin 1 decreases expression ISO pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid results in decreased expression of FN1 mRNA CTD PMID:18210741 NCBI chr 2:215,360,865...215,436,068
Ensembl chr 2:215,360,440...215,436,073
JBrowse link
G H2AX H2A.X variant histone multiple interactions EXP pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [Adenosine Triphosphate promotes the reaction [Cesium-137 results in increased expression of and affects the localization of H2AX protein modified form]] CTD PMID:32941855 NCBI chr11:119,093,874...119,095,465
Ensembl chr11:119,093,874...119,095,465
JBrowse link
G IL6 interleukin 6 multiple interactions EXP pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [Silicon Dioxide analog results in increased expression of IL6 protein] CTD PMID:24793913 NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002
JBrowse link
G NOX1 NADPH oxidase 1 multiple interactions ISO pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [NOX1 protein promotes the reaction [glycylphenylalanine 2-naphthylamide results in increased export of Calcium]] CTD PMID:24912985 NCBI chr  X:100,843,324...100,874,359
Ensembl chr  X:100,843,324...100,874,359
JBrowse link
G OXT oxytocin/neurophysin I prepropeptide multiple interactions ISO pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [[Phenylephrine co-treated with Adenosine Triphosphate] results in increased secretion of OXT protein]; pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [Adenosine Triphosphate results in increased secretion of OXT protein] CTD PMID:11102496 NCBI chr20:3,071,620...3,072,517
Ensembl chr20:3,071,620...3,072,517
JBrowse link
G P2RX7 purinergic receptor P2X 7 multiple interactions ISO
EXP
pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [Adenosine Triphosphate results in increased activity of P2RX7 protein]
pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [Adenosine Triphosphate binds to and results in increased activity of P2RX7 protein]
CTD PMID:21638035 PMID:31263019 NCBI chr12:121,132,876...121,188,032
Ensembl chr12:121,132,819...121,188,032
JBrowse link
G PARP1 poly(ADP-ribose) polymerase 1 multiple interactions ISO pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [zinc chloride results in increased expression of PARP1 protein] CTD PMID:22253048 NCBI chr 1:226,360,691...226,408,093
Ensembl chr 1:226,360,210...226,408,154
JBrowse link
G TP53BP1 tumor protein p53 binding protein 1 multiple interactions EXP pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [Adenosine Triphosphate promotes the reaction [Cesium-137 results in increased expression of and affects the localization of TP53BP1 protein]] CTD PMID:32941855 NCBI chr15:43,403,061...43,510,640
Ensembl chr15:43,403,061...43,510,728
JBrowse link
isopyridoxal term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PDXK pyridoxal kinase multiple interactions
increases phosphorylation
EXP pyridoxal phosphate gamma-aminobutyric acid inhibits the reaction [PDXK protein results in increased phosphorylation of Pyridoxal] CTD PMID:18346762 NCBI chr21:43,719,129...43,762,299
Ensembl chr21:43,719,094...43,762,307
JBrowse link
piericidin A term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MAPT microtubule associated protein tau increases response to substance
increases phosphorylation
ISO MAPT protein polymorphism results in increased susceptibility to piericidin A
piericidin A results in increased phosphorylation of MAPT protein polymorphism
CTD PMID:25437199 NCBI chr17:45,894,554...46,028,334
Ensembl chr17:45,894,527...46,028,334
JBrowse link
pyridin-2-ol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 increases activity
increases expression
EXP 2-hydroxypyridine results in increased activity of CYP1A1 protein
2-hydroxypyridine results in increased expression of CYP1A1 mRNA
CTD PMID:11849738 PMID:12147272 NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536
JBrowse link
pyridine-2,3-diol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TPO thyroid peroxidase decreases activity ISO 2,3-dihydroxypyridine results in decreased activity of TPO protein CTD PMID:26884060 NCBI chr 2:1,374,047...1,543,673
Ensembl chr 2:1,374,066...1,543,711
JBrowse link
pyridoxal term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PDXK pyridoxal kinase increases phosphorylation
multiple interactions
EXP PDXK protein results in increased phosphorylation of Pyridoxal
pyridoxal phosphate gamma-aminobutyric acid inhibits the reaction [PDXK protein results in increased phosphorylation of Pyridoxal]
CTD PMID:18346762 NCBI chr21:43,719,129...43,762,299
Ensembl chr21:43,719,094...43,762,307
JBrowse link
pyridoxal 5'-phosphate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALPL alkaline phosphatase, biomineralization associated increases abundance ISO ALPL gene mutant form results in increased abundance of Pyridoxal Phosphate CTD PMID:7550313 NCBI chr 1:21,508,984...21,578,410
Ensembl chr 1:21,509,397...21,578,410
JBrowse link
G BCL2 BCL2 apoptosis regulator decreases expression ISO Pyridoxal Phosphate results in decreased expression of BCL2 protein CTD PMID:16690808 NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128
JBrowse link
G DDC dopa decarboxylase multiple interactions
affects binding
EXP [DDC protein binds to Pyridoxal Phosphate] which binds to and results in increased metabolism of Levodopa
Chlorpyrifos binds to [DDC protein binds to Pyridoxal Phosphate]; DDC protein binds to Pyridoxal Phosphate; Diazinon binds to [DDC protein binds to Pyridoxal Phosphate]; Glyphosate binds to [DDC protein binds to Pyridoxal Phosphate]; Isoflurophate binds to [DDC protein binds to Pyridoxal Phosphate]; Malathion binds to [DDC protein binds to Pyridoxal Phosphate]; mipafox binds to [DDC protein binds to Pyridoxal Phosphate]; novichok binds to [DDC protein binds to Pyridoxal Phosphate]; O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate binds to [DDC protein binds to Pyridoxal Phosphate]; Paraoxon binds to [DDC protein binds to Pyridoxal Phosphate]; phenyl di-n-pentylphosphinate binds to [DDC protein binds to Pyridoxal Phosphate]; phenylsaligenin cyclic phosphate binds to [DDC protein binds to Pyridoxal Phosphate]; S-(N,N-diethylaminoethyl) isobutyl methylphosphothiolate binds to [DDC protein binds to Pyridoxal Phosphate]; Sarin binds to [DDC protein binds to Pyridoxal Phosphate]; Soman binds to [DDC protein binds to Pyridoxal Phosphate]; tabun binds to [DDC protein binds to Pyridoxal Phosphate]; VX binds to [DDC protein binds to Pyridoxal Phosphate]
CTD PMID:35151785 NCBI chr 7:50,458,442...50,565,405
Ensembl chr 7:50,458,436...50,565,405
JBrowse link
G FN1 fibronectin 1 multiple interactions ISO Pyridoxal Phosphate inhibits the reaction [Acetaldehyde results in increased expression of FN1 mRNA] CTD PMID:8151099 NCBI chr 2:215,360,865...215,436,068
Ensembl chr 2:215,360,440...215,436,073
JBrowse link
G FUT8 fucosyltransferase 8 multiple interactions
decreases activity
EXP Fucose analog inhibits the reaction [Pyridoxal Phosphate results in decreased activity of FUT8 protein] CTD PMID:12770769 NCBI chr14:65,356,842...65,744,121
Ensembl chr14:65,410,592...65,744,121
JBrowse link
G GAD1 glutamate decarboxylase 1 affects binding
multiple interactions
decreases activity
increases activity
EXP
ISO
Chlorpyrifos binds to [GAD1 protein binds to Pyridoxal Phosphate]; Diazinon binds to [GAD1 protein binds to Pyridoxal Phosphate]; GAD1 protein binds to Pyridoxal Phosphate; Glyphosate binds to [GAD1 protein binds to Pyridoxal Phosphate]; Isoflurophate binds to [GAD1 protein binds to Pyridoxal Phosphate]; Malathion binds to [GAD1 protein binds to Pyridoxal Phosphate]; mipafox binds to [GAD1 protein binds to Pyridoxal Phosphate]; novichok binds to [GAD1 protein binds to Pyridoxal Phosphate]; O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate binds to [GAD1 protein binds to Pyridoxal Phosphate]; Paraoxon binds to [GAD1 protein binds to Pyridoxal Phosphate]; phenyl di-n-pentylphosphinate binds to [GAD1 protein binds to Pyridoxal Phosphate]; phenylsaligenin cyclic phosphate binds to [GAD1 protein binds to Pyridoxal Phosphate]; Pyridoxal Phosphate binds to GAD1 protein modified form; S-(N,N-diethylaminoethyl) isobutyl methylphosphothiolate binds to [GAD1 protein binds to Pyridoxal Phosphate]; Sarin binds to [GAD1 protein binds to Pyridoxal Phosphate]; Soman binds to [GAD1 protein binds to Pyridoxal Phosphate]; tabun binds to [GAD1 protein binds to Pyridoxal Phosphate]; VX binds to [GAD1 protein binds to Pyridoxal Phosphate]
[GAD1 protein binds to Pyridoxal Phosphate] which binds to and results in increased metabolism of Glutamic Acid
Pyridoxal Phosphate results in decreased activity of GAD1 protein
Pyridoxal Phosphate results in increased activity of GAD1 protein
CTD PMID:171340 PMID:7463050 PMID:15686475 PMID:35151785 NCBI chr 2:170,813,210...170,861,151
Ensembl chr 2:170,813,213...170,861,151
JBrowse link
G GAD2 glutamate decarboxylase 2 affects binding
multiple interactions
EXP Chlorpyrifos binds to [GAD2 protein binds to Pyridoxal Phosphate]; Diazinon binds to [GAD2 protein binds to Pyridoxal Phosphate]; GAD2 protein binds to Pyridoxal Phosphate; Glyphosate binds to [GAD2 protein binds to Pyridoxal Phosphate]; Isoflurophate binds to [GAD2 protein binds to Pyridoxal Phosphate]; Malathion binds to [GAD2 protein binds to Pyridoxal Phosphate]; mipafox binds to [GAD2 protein binds to Pyridoxal Phosphate]; novichok binds to [GAD2 protein binds to Pyridoxal Phosphate]; O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate binds to [GAD2 protein binds to Pyridoxal Phosphate]; Paraoxon binds to [GAD2 protein binds to Pyridoxal Phosphate]; phenyl di-n-pentylphosphinate binds to [GAD2 protein binds to Pyridoxal Phosphate]; phenylsaligenin cyclic phosphate binds to [GAD2 protein binds to Pyridoxal Phosphate]; Pyridoxal Phosphate binds to GAD2 protein; Pyridoxal Phosphate binds to GAD2 protein modified form; S-(N,N-diethylaminoethyl) isobutyl methylphosphothiolate binds to [GAD2 protein binds to Pyridoxal Phosphate]; Sarin binds to [GAD2 protein binds to Pyridoxal Phosphate]; Soman binds to [GAD2 protein binds to Pyridoxal Phosphate]; tabun binds to [GAD2 protein binds to Pyridoxal Phosphate]; VX binds to [GAD2 protein binds to Pyridoxal Phosphate]
[GAD2 protein binds to Pyridoxal Phosphate] which binds to and results in increased metabolism of Glutamic Acid
CTD PMID:15686475 PMID:15690345 PMID:15836621 PMID:35151785 NCBI chr10:26,216,372...26,304,558
Ensembl chr10:26,216,665...26,304,558
JBrowse link
G GH1 growth hormone 1 decreases secretion ISO Pyridoxal Phosphate results in decreased secretion of GH1 protein CTD PMID:16690808 NCBI chr17:63,917,203...63,918,839
Ensembl chr17:63,917,200...63,918,839
JBrowse link
G HDC histidine decarboxylase affects binding
multiple interactions
EXP Chlorpyrifos binds to [HDC protein binds to Pyridoxal Phosphate]; Diazinon binds to [HDC protein binds to Pyridoxal Phosphate]; Glyphosate binds to [HDC protein binds to Pyridoxal Phosphate]; HDC protein binds to Pyridoxal Phosphate; Isoflurophate binds to [HDC protein binds to Pyridoxal Phosphate]; Malathion binds to [HDC protein binds to Pyridoxal Phosphate]; mipafox binds to [HDC protein binds to Pyridoxal Phosphate]; novichok binds to [HDC protein binds to Pyridoxal Phosphate]; O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate binds to [HDC protein binds to Pyridoxal Phosphate]; Paraoxon binds to [HDC protein binds to Pyridoxal Phosphate]; phenyl di-n-pentylphosphinate binds to [HDC protein binds to Pyridoxal Phosphate]; phenylsaligenin cyclic phosphate binds to [HDC protein binds to Pyridoxal Phosphate]; S-(N,N-diethylaminoethyl) isobutyl methylphosphothiolate binds to [HDC protein binds to Pyridoxal Phosphate]; Sarin binds to [HDC protein binds to Pyridoxal Phosphate]; Soman binds to [HDC protein binds to Pyridoxal Phosphate]; tabun binds to [HDC protein binds to Pyridoxal Phosphate]; VX binds to [HDC protein binds to Pyridoxal Phosphate]
[HDC protein binds to Pyridoxal Phosphate] which binds to and results in increased metabolism of Histidine
CTD PMID:35151785 NCBI chr15:50,241,947...50,265,726
Ensembl chr15:50,241,947...50,265,965
JBrowse link
G NRIP1 nuclear receptor interacting protein 1 multiple interactions ISO Pyridoxal Phosphate binds to and results in increased activity of NRIP1 protein CTD PMID:17277785 NCBI chr21:14,961,235...15,065,936
Ensembl chr21:14,961,235...15,065,936
JBrowse link
G PDXK pyridoxal kinase increases abundance EXP PDXK protein results in increased abundance of Pyridoxal Phosphate CTD PMID:18346762 NCBI chr21:43,719,129...43,762,299
Ensembl chr21:43,719,094...43,762,307
JBrowse link
G POMC proopiomelanocortin decreases secretion ISO Pyridoxal Phosphate results in decreased secretion of POMC protein CTD PMID:16690808 NCBI chr 2:25,160,860...25,168,580
Ensembl chr 2:25,160,853...25,168,903
JBrowse link
G PPARA peroxisome proliferator activated receptor alpha multiple interactions ISO Pyridoxal Phosphate inhibits the reaction [Ethanol results in decreased activity of PPARA protein] CTD PMID:11022051 NCBI chr22:46,150,526...46,243,756
Ensembl chr22:46,150,521...46,243,755
JBrowse link
G PRL prolactin decreases secretion ISO Pyridoxal Phosphate results in decreased secretion of PRL protein CTD PMID:16690808 NCBI chr 6:22,287,246...22,302,835
Ensembl chr 6:22,287,244...22,302,826
JBrowse link
G SRR serine racemase multiple interactions ISO Pyridoxal Phosphate inhibits the reaction [Hydroxylamine inhibits the reaction [SRR protein results in increased abundance of D-Aspartic Acid]] CTD PMID:27387750 NCBI chr17:2,303,378...2,325,264
Ensembl chr17:2,303,383...2,325,260
JBrowse link
pyridoxamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GSR glutathione-disulfide reductase decreases activity ISO Pyridoxamine results in decreased activity of GSR protein CTD PMID:24831520 NCBI chr 8:30,678,066...30,727,846
Ensembl chr 8:30,678,066...30,727,846
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 decreases activity ISO Pyridoxamine results in decreased activity of PTGS2 protein CTD PMID:20041722 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922
JBrowse link
G SOD2 superoxide dismutase 2 increases activity ISO Pyridoxamine results in increased activity of SOD2 protein CTD PMID:24831520 NCBI chr 6:159,669,069...159,762,281
Ensembl chr 6:159,669,069...159,762,529
JBrowse link
G SPHK1 sphingosine kinase 1 multiple interactions ISO Pyridoxamine inhibits the reaction [Glucose results in increased expression of and results in increased activity of SPHK1 protein] CTD PMID:21998146 NCBI chr17:76,383,204...76,387,855
Ensembl chr17:76,376,584...76,387,860
JBrowse link
G TGFB1 transforming growth factor beta 1 multiple interactions ISO Pyridoxamine inhibits the reaction [Streptozocin results in increased expression of TGFB1 mRNA] CTD PMID:15309289 NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922
JBrowse link
G TNF tumor necrosis factor multiple interactions ISO Pyridoxamine inhibits the reaction [Streptozocin results in increased expression of TNF protein] CTD PMID:15309289 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
JBrowse link
pyridoxine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BAX BCL2 associated X, apoptosis regulator increases expression EXP Pyridoxine results in increased expression of BAX mRNA CTD PMID:28716455 NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798
JBrowse link
G CASP8 caspase 8 increases expression EXP Pyridoxine results in increased expression of CASP8 mRNA CTD PMID:28716455 NCBI chr 2:201,233,463...201,287,711
Ensembl chr 2:201,233,443...201,361,836
JBrowse link
G NEFL neurofilament light chain increases secretion ISO Pyridoxine results in increased secretion of NEFL protein CTD PMID:34677616 NCBI chr 8:24,950,955...24,956,612
Ensembl chr 8:24,950,955...24,956,721
JBrowse link
G PPARGC1A PPARG coactivator 1 alpha increases expression EXP
ISO
Pyridoxine results in increased expression of PPARGC1A mRNA CTD PMID:23056435 NCBI chr 4:23,792,021...24,472,905
Ensembl chr 4:23,755,041...23,904,089
JBrowse link
G SHMT1 serine hydroxymethyltransferase 1 multiple interactions EXP Pyridoxine affects the expression of and affects the activity of SHMT1 protein CTD PMID:17482557 NCBI chr17:18,327,873...18,363,550
Ensembl chr17:18,327,873...18,363,550
JBrowse link
pyrithione term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKT1 AKT serine/threonine kinase 1 multiple interactions ISO [Zinc co-treated with pyrithione] results in increased phosphorylation of and results in increased activity of AKT1 protein; AKT1 protein promotes the reaction [[Zinc co-treated with pyrithione] results in increased phosphorylation of and results in increased activity of GSK3B protein] CTD PMID:17098228 NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,751
JBrowse link
G CD14 CD14 molecule multiple interactions EXP [Zinc co-treated with pyrithione] inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [Calcitriol results in increased expression of CD14 protein]]; pyrithione promotes the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [Calcitriol results in increased expression of CD14 protein]] CTD PMID:20089671 NCBI chr 5:140,631,732...140,633,701
Ensembl chr 5:140,631,728...140,633,700
JBrowse link
G CD86 CD86 molecule multiple interactions ISO pyrithione inhibits the reaction [Lipopolysaccharides results in increased expression of CD86] CTD PMID:17126599 NCBI chr 3:122,055,362...122,121,136
Ensembl chr 3:122,055,362...122,121,139
JBrowse link
G CSNK2A1 casein kinase 2 alpha 1 multiple interactions EXP 2-dimethylamino-4,5,6,7-tetrabromo-1H-benzimidazole inhibits the reaction [[Zinc co-treated with pyrithione] promotes the reaction [CSNK2A1 protein binds to SLC39A7 protein]]; 4,5,6,7-tetrabromobenzotriazole inhibits the reaction [[Zinc co-treated with pyrithione] promotes the reaction [CSNK2A1 protein binds to SLC39A7 protein]]; [Zinc co-treated with pyrithione] promotes the reaction [CSNK2A1 protein binds to SLC39A7 protein] CTD PMID:22317921 NCBI chr20:472,498...543,790
Ensembl chr20:472,498...543,835
JBrowse link
G CTNNB1 catenin beta 1 multiple interactions ISO [Zinc co-treated with pyrithione] results in increased cleavage of CTNNB1 protein CTD PMID:17098228 NCBI chr 3:41,199,505...41,240,443
Ensembl chr 3:41,194,741...41,260,096
JBrowse link
G GSK3B glycogen synthase kinase 3 beta multiple interactions ISO [Zinc co-treated with pyrithione] results in increased phosphorylation of and results in increased activity of GSK3B protein; AKT1 protein promotes the reaction [[Zinc co-treated with pyrithione] results in increased phosphorylation of and results in increased activity of GSK3B protein]; GSK3B protein promotes the reaction [[Zinc co-treated with pyrithione] results in increased phosphorylation of MAPT protein] CTD PMID:17098228 NCBI chr 3:119,821,321...120,094,447
Ensembl chr 3:119,821,321...120,094,994
JBrowse link
G HGF hepatocyte growth factor multiple interactions ISO [Zinc co-treated with pyrithione] promotes the reaction [HGF protein results in increased expression of PCNA mRNA] CTD PMID:22374166 NCBI chr 7:81,699,010...81,770,047
Ensembl chr 7:81,699,010...81,770,438
JBrowse link
G HMOX1 heme oxygenase 1 increases expression ISO pyrithione analog results in increased expression of HMOX1 mRNA CTD PMID:23085594 NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,214
JBrowse link
G ITGAM integrin subunit alpha M multiple interactions EXP [Zinc co-treated with pyrithione] inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [Calcitriol results in increased expression of ITGAM protein]]; pyrithione promotes the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [Calcitriol results in increased expression of ITGAM protein]] CTD PMID:20089671 NCBI chr16:31,259,975...31,332,877
Ensembl chr16:31,259,967...31,332,892
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions ISO [Zinc co-treated with pyrithione] results in increased phosphorylation of MAPK1 protein CTD PMID:20201035 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions ISO [Zinc co-treated with pyrithione] results in increased phosphorylation of MAPK3 protein CTD PMID:20201035 NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506
JBrowse link
G MAPT microtubule associated protein tau multiple interactions ISO [Zinc co-treated with pyrithione] results in increased phosphorylation of MAPT protein; GSK3B protein promotes the reaction [[Zinc co-treated with pyrithione] results in increased phosphorylation of MAPT protein] CTD PMID:17098228 NCBI chr17:45,894,554...46,028,334
Ensembl chr17:45,894,527...46,028,334
JBrowse link
G MT1X metallothionein 1X increases expression ISO pyrithione analog results in increased expression of MT1 mRNA CTD PMID:23085594 NCBI chr16:56,682,470...56,684,196
Ensembl chr16:56,682,470...56,684,196
JBrowse link
G PCNA proliferating cell nuclear antigen multiple interactions ISO [Zinc co-treated with pyrithione] promotes the reaction [HGF protein results in increased expression of PCNA mRNA] CTD PMID:22374166 NCBI chr20:5,114,953...5,126,622
Ensembl chr20:5,114,953...5,126,626
JBrowse link
G PTPN1 protein tyrosine phosphatase non-receptor type 1 multiple interactions ISO [Zinc co-treated with pyrithione] results in decreased activity of PTPN1 protein CTD PMID:22374166 NCBI chr20:50,510,383...50,585,241
Ensembl chr20:50,510,321...50,585,241
JBrowse link
G SLC39A7 solute carrier family 39 member 7 multiple interactions EXP 2-dimethylamino-4,5,6,7-tetrabromo-1H-benzimidazole inhibits the reaction [[Zinc co-treated with pyrithione] promotes the reaction [CSNK2A1 protein binds to SLC39A7 protein]]; 4,5,6,7-tetrabromobenzotriazole inhibits the reaction [[Zinc co-treated with pyrithione] promotes the reaction [CSNK2A1 protein binds to SLC39A7 protein]]; [Zinc co-treated with pyrithione] promotes the reaction [CSNK2A1 protein binds to SLC39A7 protein] CTD PMID:22317921 NCBI chr 6:33,200,867...33,204,437
Ensembl chr 6:33,200,305...33,204,439
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 26041
    chemical entity 26020
      molecular entity 25998
        polyatomic entity 25883
          heteroatomic molecular entity 25534
            hydroxides 24056
              organic hydroxy compound 22071
                heteroaryl hydroxy compound 1740
                  hydroxypyridine 89
                    2-[3-Hydroxy-5-(hydroxymethyl)-2-methyl-4-pyridinyl]-4-thiazolidinecarboxylic acid 0
                    2-butan-2-yl-3-hydroxy-5-(hydroxymethyl)-1H-pyridin-4-one 0
                    3,5,6-trichloro-2-pyridinol 31
                    3,6-dichloropyridine-2,5-diol 0
                    3,6-dihydroxypyridine-2,5-dione 0
                    3-hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde oxime 0
                    5-(2'-hydroxypropyl)pyridin-3-OL 0
                    5-Chloropyridin-3-ol 0
                    5-Hydroxy-2-pyridinemethanol 0
                    6-chloropyridine-2,3,5-triol 0
                    6-hydroxy-pseudooxy-nornicotine 0
                    Huptremule A 0
                    Huptremule B 0
                    Isokuraramine 0
                    Pirbuterol acetate 0
                    Pirbuterol hydrochloride 0
                    Siderochelin A 0
                    Siderochelin B 0
                    dihydroxypyridine + 1
                    haloxydine 0
                    monohydroxypyridine + 58
                    triihydroxypyridine + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 26041
    subatomic particle 26016
      composite particle 26016
        hadron 26016
          baryon 26016
            nucleon 26016
              atomic nucleus 26016
                atom 26016
                  main group element atom 25841
                    p-block element atom 25841
                      carbon group element atom 25441
                        carbon atom 25399
                          organic molecular entity 25399
                            organic molecule 25228
                              organic cyclic compound 24281
                                organic heterocyclic compound 22324
                                  organic heteromonocyclic compound 19228
                                    pyridines 12194
                                      hydroxypyridine 89
                                        2-[3-Hydroxy-5-(hydroxymethyl)-2-methyl-4-pyridinyl]-4-thiazolidinecarboxylic acid 0
                                        2-butan-2-yl-3-hydroxy-5-(hydroxymethyl)-1H-pyridin-4-one 0
                                        3,5,6-trichloro-2-pyridinol 31
                                        3,6-dichloropyridine-2,5-diol 0
                                        3,6-dihydroxypyridine-2,5-dione 0
                                        3-hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde oxime 0
                                        5-(2'-hydroxypropyl)pyridin-3-OL 0
                                        5-Chloropyridin-3-ol 0
                                        5-Hydroxy-2-pyridinemethanol 0
                                        6-chloropyridine-2,3,5-triol 0
                                        6-hydroxy-pseudooxy-nornicotine 0
                                        Huptremule A 0
                                        Huptremule B 0
                                        Isokuraramine 0
                                        Pirbuterol acetate 0
                                        Pirbuterol hydrochloride 0
                                        Siderochelin A 0
                                        Siderochelin B 0
                                        dihydroxypyridine + 1
                                        haloxydine 0
                                        monohydroxypyridine + 58
                                        triihydroxypyridine + 0
paths to the root