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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:adefovir
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Accession:CHEBI:2469 term browser browse the term
Definition:A member of the class of phosphonic acids that is methylphosphonic acid in which one of the methyl hydrogens has been replaced by a 2-(6-amino-9H-purin-9-yl)ethoxy group. An inhibitor of HIV-1 reverse transcriptase, the bis(t-butoxycarbonyloxymethyl) ester (dipivoxil ester) prodrug is used to treat chronic hepatitis B viral infection.
Synonyms:exact_synonym: {[2-(6-amino-9H-purin-9-yl)ethoxy]methyl}phosphonic acid
 related_synonym: 9-(2-(Phosphonomethoxy)ethyl)adenine;   9-(2-Phosphonylmethoxyethyl)adenine;   DRG-0156;   Formula=C8H12N5O4P;   GS 0393;   GS 393;   HSDB 8079;   InChI=1S/C8H12N5O4P/c9-7-6-8(11-3-10-7)13(4-12-6)1-2-17-5-18(14,15)16/h3-4H,1-2,5H2,(H2,9,10,11)(H2,14,15,16);   InChIKey=SUPKOOSCJHTBAH-UHFFFAOYSA-N;   N-(2-Phosphonylmethoxyethyl)adenine;   PMEA;   SMILES=N1(C2=C(C(N)=NC=N2)N=C1)CCOCP(O)(=O)O
 alt_id: CHEBI:40188
 xref: Beilstein:3561094;   CAS:106941-25-7;   DrugBank:DB00718;   KEGG:C11277;   KEGG:D02768
 xref_mesh: MESH:C053001
 xref: PDBeChem:5HG;   PMID:10676990;   PMID:11796353;   PMID:14647052;   PMID:14978283;   PMID:15866657;   PMID:22976988;   PMID:24338503;   PMID:27079793;   PMID:27381944;   PMID:27649318;   PMID:27664568;   PMID:27698751;   PMID:27729626;   PMID:27746441;   PMID:27806120;   PMID:27858892;   PMID:27880997;   PMID:27977591;   PMID:28011962;   PMID:28079295;   PMID:28081595;   PMID:28123560;   PMID:28322924;   PMID:28397817;   PMID:28436380;   Reaxys:3561094;   Wikipedia:Adefovir
 cyclic_relationship: is_conjugate_acid_of CHEBI:134512


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adefovir term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb4 ATP binding cassette subfamily B member 4 multiple interactions
affects transport
EXP Calcitriol promotes the reaction [ABCB4 protein affects the transport of adefovir] CTD PMID:21240898, PMID:21341280 NCBI chr 4:22,133,984...22,192,687
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcc4 ATP binding cassette subfamily C member 4 affects abundance
increases export
ISO ABCC4 protein affects the abundance of adefovir
ABCC4 protein results in increased export of adefovir
CTD PMID:18364470 NCBI chr15:103,695,415...103,927,980
Ensembl chr15:103,696,557...103,927,592
JBrowse link
G B2m beta-2 microglobulin increases secretion EXP adefovir results in increased secretion of B2M protein CTD PMID:27742868 NCBI chr 3:114,087,287...114,093,311
Ensembl chr 3:114,087,287...114,093,309
JBrowse link
G Calb1 calbindin 1 increases secretion EXP adefovir results in increased secretion of CALB1 protein CTD PMID:27742868 NCBI chr 5:29,538,380...29,562,774
Ensembl chr 5:29,538,380...29,562,773
JBrowse link
G Havcr1 hepatitis A virus cellular receptor 1 increases secretion EXP adefovir results in increased secretion of HAVCR1 protein CTD PMID:27742868 NCBI chr10:31,813,819...31,860,934
Ensembl chr10:31,813,814...31,848,379
JBrowse link
G Lcn2 lipocalin 2 increases secretion EXP adefovir results in increased secretion of LCN2 protein CTD PMID:27742868 NCBI chr 3:11,414,189...11,417,534
Ensembl chr 3:11,414,186...11,417,546
JBrowse link
G Mmut methylmalonyl-CoA mutase affects expression
increases expression
ISO adefovir affects the expression of MMUT mRNA mutant form; adefovir affects the expression of MMUT protein mutant form
adefovir results in increased expression of MMUT mRNA; adefovir results in increased expression of MMUT protein
CTD PMID:19199343, PMID:19427250 NCBI chr 9:23,323,934...23,352,144
Ensembl chr 9:23,323,936...23,352,668
JBrowse link
G Slc22a6 solute carrier family 22 member 6 increases uptake
affects response to substance
multiple interactions
increases response to substance
EXP
ISO
SLC22A6 protein results in increased uptake of adefovir
SLC22A6 protein affects the susceptibility to adefovir
adefovir inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid]; Probenecid inhibits the reaction [SLC22A6 protein results in increased susceptibility to adefovir]; quercetin 3'-sulfate inhibits the reaction [SLC22A6 protein affects the susceptibility to adefovir]; SLC22A6 protein results in increased uptake of and results in increased susceptibility to adefovir
CTD PMID:16857889, PMID:21244849, PMID:23856525, PMID:25448811 NCBI chr 1:224,824,809...224,833,284
Ensembl chr 1:224,824,799...224,833,259
JBrowse link
G Slc22a8 solute carrier family 22 member 8 increases response to substance ISO SLC22A8 protein results in increased susceptibility to adefovir CTD PMID:25448811 NCBI chr 1:224,799,444...224,818,482
Ensembl chr 1:224,800,252...224,818,482
JBrowse link
G Spp1 secreted phosphoprotein 1 increases secretion EXP adefovir results in increased secretion of SPP1 protein CTD PMID:27742868 NCBI chr14:6,673,686...6,679,965
Ensembl chr14:6,673,686...6,679,901
JBrowse link
adefovir pivoxil term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor affects activity ISO adefovir dipivoxil affects the activity of AHR protein CTD PMID:25596134 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Ak4 adenylate kinase 4 increases expression ISO adefovir dipivoxil results in increased expression of AK4 mRNA CTD PMID:25596134 NCBI chr 5:120,250,318...120,309,153
Ensembl chr 5:120,250,616...120,305,897
JBrowse link
G Akr1c2 aldo-keto reductase family 1, member C2 decreases expression ISO adefovir dipivoxil results in decreased expression of AKR1C2 mRNA CTD PMID:25596134 NCBI chr17:69,388,337...69,435,160
Ensembl chr17:69,388,335...69,404,341
JBrowse link
G Aldh18a1 aldehyde dehydrogenase 18 family, member A1 decreases expression ISO adefovir dipivoxil results in decreased expression of ALDH18A1 mRNA CTD PMID:25596134 NCBI chr 1:259,641,673...259,674,521
Ensembl chr 1:259,641,676...259,674,425
Ensembl chr 1:259,641,676...259,674,425
JBrowse link
G Aldh1a3 aldehyde dehydrogenase 1 family, member A3 increases expression ISO adefovir dipivoxil results in increased expression of ALDH1A3 mRNA CTD PMID:25596134 NCBI chr 1:127,302,920...127,337,828
Ensembl chr 1:127,301,128...127,337,882
JBrowse link
G Als2cl ALS2 C-terminal like increases expression ISO adefovir dipivoxil results in increased expression of ALS2CL mRNA CTD PMID:25596134 NCBI chr 8:119,156,081...119,176,680
Ensembl chr 8:119,160,731...119,174,830
JBrowse link
G Angptl4 angiopoietin-like 4 increases expression ISO adefovir dipivoxil results in increased expression of ANGPTL4 mRNA CTD PMID:25596134 NCBI chr 7:18,627,814...18,634,043
Ensembl chr 7:18,627,808...18,634,079
JBrowse link
G Asns asparagine synthetase (glutamine-hydrolyzing) decreases expression ISO adefovir dipivoxil results in decreased expression of ASNS mRNA CTD PMID:25596134 NCBI chr 4:33,742,876...33,761,106
Ensembl chr 4:33,743,364...33,761,163
JBrowse link
G Atad2 ATPase family, AAA domain containing 2 increases expression ISO adefovir dipivoxil results in increased expression of ATAD2 mRNA CTD PMID:25596134 NCBI chr 7:97,984,754...98,027,379
Ensembl chr 7:97,984,862...98,026,052
JBrowse link
G Atf3 activating transcription factor 3 increases expression ISO adefovir dipivoxil results in increased expression of ATF3 mRNA CTD PMID:25596134 NCBI chr13:109,817,892...109,849,632
Ensembl chr13:109,817,728...109,849,632
JBrowse link
G Aurkb aurora kinase B increases expression ISO adefovir dipivoxil results in increased expression of AURKB mRNA CTD PMID:25596134 NCBI chr10:55,625,860...55,632,399
Ensembl chr10:55,626,741...55,634,991
JBrowse link
G Axl Axl receptor tyrosine kinase increases expression ISO adefovir dipivoxil results in increased expression of AXL mRNA CTD PMID:25596134 NCBI chr 1:82,550,892...82,580,761
Ensembl chr 1:82,549,420...82,580,761
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO adefovir dipivoxil results in increased expression of BAX mRNA CTD PMID:25596134 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bend5 BEN domain containing 5 decreases expression ISO adefovir dipivoxil results in decreased expression of BEND5 mRNA CTD PMID:25596134 NCBI chr 5:131,257,127...131,312,335
Ensembl chr 5:131,257,127...131,312,335
JBrowse link
G Bmf Bcl2 modifying factor decreases expression ISO adefovir dipivoxil results in decreased expression of BMF mRNA CTD PMID:25596134 NCBI chr 3:110,303,515...110,324,125
Ensembl chr 3:110,306,067...110,324,084
JBrowse link
G Btg2 BTG anti-proliferation factor 2 increases expression ISO adefovir dipivoxil results in increased expression of BTG2 mRNA CTD PMID:25596134 NCBI chr13:50,913,185...50,916,944
Ensembl chr13:50,913,180...50,916,982
JBrowse link
G Ccne2 cyclin E2 increases expression ISO adefovir dipivoxil results in increased expression of CCNE2 mRNA CTD PMID:25596134 NCBI chr 5:24,434,077...24,446,406
Ensembl chr 5:24,434,872...24,446,406
JBrowse link
G Cdk6 cyclin-dependent kinase 6 increases expression ISO adefovir dipivoxil results in increased expression of CDK6 mRNA CTD PMID:25596134 NCBI chr 4:27,781,728...27,969,653
Ensembl chr 4:27,785,647...27,966,398
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO adefovir dipivoxil results in increased expression of CDKN1A mRNA CTD PMID:25596134 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cmbl carboxymethylenebutenolidase homolog increases expression ISO adefovir dipivoxil results in increased expression of CMBL mRNA CTD PMID:25596134 NCBI chr 2:84,645,084...84,666,836
Ensembl chr 2:84,645,084...84,666,835
JBrowse link
G Coch cochlin increases expression ISO adefovir dipivoxil results in increased expression of COCH mRNA CTD PMID:25596134 NCBI chr 6:72,359,702...72,373,710
Ensembl chr 6:72,359,791...72,373,695
JBrowse link
G Col4a1 collagen type IV alpha 1 chain decreases expression ISO adefovir dipivoxil results in decreased expression of COL4A1 mRNA CTD PMID:25596134 NCBI chr16:83,522,162...83,632,153
Ensembl chr16:83,522,162...83,632,153
JBrowse link
G Cth cystathionine gamma-lyase decreases expression ISO adefovir dipivoxil results in decreased expression of CTH mRNA CTD PMID:25596134 NCBI chr 2:264,266,959...264,293,040
Ensembl chr 2:264,266,984...264,293,046
JBrowse link
G Ctsc cathepsin C decreases expression ISO adefovir dipivoxil results in decreased expression of CTSC mRNA CTD PMID:25596134 NCBI chr 1:151,918,514...151,949,979
Ensembl chr 1:151,918,571...151,949,983
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 increases expression ISO adefovir dipivoxil results in increased expression of CYP1B1 mRNA CTD PMID:25596134 NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722
JBrowse link
G Ddb2 damage specific DNA binding protein 2 increases expression ISO adefovir dipivoxil results in increased expression of DDB2 mRNA CTD PMID:25596134 NCBI chr 3:80,030,437...80,052,984
Ensembl chr 3:80,030,437...80,052,953
JBrowse link
G Dgka diacylglycerol kinase, alpha increases expression ISO adefovir dipivoxil results in increased expression of DGKA mRNA CTD PMID:25596134 NCBI chr 7:3,143,826...3,170,764
Ensembl chr 7:3,143,827...3,170,146
JBrowse link
G Dlgap5 DLG associated protein 5 increases expression ISO adefovir dipivoxil results in increased expression of DLGAP5 mRNA CTD PMID:25596134 NCBI chr15:24,167,484...24,199,417
Ensembl chr15:24,167,486...24,199,341
JBrowse link
G Dlx1 distal-less homeobox 1 decreases expression ISO adefovir dipivoxil results in decreased expression of DLX1 mRNA CTD PMID:25596134 NCBI chr 3:58,164,931...58,169,521
Ensembl chr 3:58,164,931...58,169,521
JBrowse link
G Dnai3 dynein axonemal intermediate chain 3 increases expression ISO adefovir dipivoxil results in increased expression of DNAI3 mRNA CTD PMID:25596134 NCBI chr 2:251,912,432...251,970,699
Ensembl chr 2:251,912,368...251,970,768
JBrowse link
G Dpysl3 dihydropyrimidinase-like 3 increases expression ISO adefovir dipivoxil results in increased expression of DPYSL3 mRNA CTD PMID:25596134 NCBI chr18:37,716,371...37,819,347
Ensembl chr18:37,716,143...37,819,097
JBrowse link
G Efna1 ephrin A1 decreases expression ISO adefovir dipivoxil results in decreased expression of EFNA1 mRNA CTD PMID:25596134 NCBI chr 2:188,588,808...188,596,156
Ensembl chr 2:188,588,796...188,596,222
JBrowse link
G Ero1a endoplasmic reticulum oxidoreductase 1 alpha increases expression ISO adefovir dipivoxil results in increased expression of ERO1A mRNA CTD PMID:25596134 NCBI chr15:19,619,947...19,655,381
Ensembl chr15:19,619,973...19,655,381
JBrowse link
G Fas Fas cell surface death receptor increases expression ISO adefovir dipivoxil results in increased expression of FAS mRNA CTD PMID:25596134 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790
JBrowse link
G Fbxo22 F-box protein 22 increases expression ISO adefovir dipivoxil results in increased expression of FBXO22 mRNA CTD PMID:25596134 NCBI chr 8:59,770,032...59,786,061
Ensembl chr 8:59,769,994...59,786,065
JBrowse link
G Gabarapl1 GABA type A receptor associated protein like 1 decreases expression ISO adefovir dipivoxil results in decreased expression of GABARAPL1 mRNA CTD PMID:25596134 NCBI chr 4:163,293,724...163,302,866
Ensembl chr 4:163,293,724...163,302,858
JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha increases expression ISO adefovir dipivoxil results in increased expression of GADD45A mRNA CTD PMID:25596134 NCBI chr 4:97,782,512...97,784,814
Ensembl chr 4:97,782,512...97,784,842
JBrowse link
G Galnt16 polypeptide N-acetylgalactosaminyltransferase 16 decreases expression ISO adefovir dipivoxil results in decreased expression of GALNT16 mRNA CTD PMID:25596134 NCBI chr 6:104,069,853...104,250,177
Ensembl chr 6:104,068,547...104,250,174
JBrowse link
G Gcnt3 glucosaminyl (N-acetyl) transferase 3, mucin type increases expression ISO adefovir dipivoxil results in increased expression of GCNT3 mRNA CTD PMID:25596134 NCBI chr 8:76,449,078...76,459,431
Ensembl chr 8:76,449,081...76,452,554
JBrowse link
G Gdf15 growth differentiation factor 15 increases expression ISO adefovir dipivoxil results in increased expression of GDF15 mRNA CTD PMID:25596134 NCBI chr16:20,555,395...20,557,978
Ensembl chr16:20,555,395...20,557,978
JBrowse link
G Got1 glutamic-oxaloacetic transaminase 1 decreases expression ISO adefovir dipivoxil results in decreased expression of GOT1 mRNA CTD PMID:25596134 NCBI chr 1:263,246,248...263,269,762
Ensembl chr 1:263,246,248...263,269,762
JBrowse link
G Gpr87 G protein-coupled receptor 87 increases expression ISO adefovir dipivoxil results in increased expression of GPR87 mRNA CTD PMID:25596134 NCBI chr 2:149,398,949...149,418,041
Ensembl chr 2:149,398,949...149,417,212
JBrowse link
G H1f2 H1.2 linker histone, cluster member increases expression ISO adefovir dipivoxil results in increased expression of H1-2 mRNA CTD PMID:25596134 NCBI chr17:43,638,938...43,640,445
Ensembl chr17:43,639,749...43,640,387
JBrowse link
G Hmox1 heme oxygenase 1 decreases expression ISO adefovir dipivoxil results in decreased expression of HMOX1 mRNA CTD PMID:25596134 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hspa1b heat shock protein family A (Hsp70) member 1B decreases expression ISO adefovir dipivoxil results in decreased expression of HSPA1B mRNA CTD PMID:25596134 NCBI chr20:4,877,638...4,880,112
Ensembl chr20:2,699,712...2,701,815
JBrowse link
G Ifng interferon gamma multiple interactions ISO adefovir dipivoxil inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased activity of NOS2 protein]; adefovir dipivoxil inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; adefovir dipivoxil inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 protein] CTD PMID:9354585 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Il19 interleukin 19 increases secretion ISO adefovir dipivoxil results in increased secretion of IL19 protein CTD PMID:24714768 NCBI chr13:47,663,592...47,677,869
Ensembl chr13:47,664,080...47,670,407
JBrowse link
G Kat6b lysine acetyltransferase 6B decreases expression ISO adefovir dipivoxil results in decreased expression of KAT6B mRNA CTD PMID:25596134 NCBI chr15:2,811,933...2,966,833
Ensembl chr15:2,813,537...2,966,576
JBrowse link
G Kdm3a lysine demethylase 3A decreases expression ISO adefovir dipivoxil results in decreased expression of KDM3A mRNA CTD PMID:25596134 NCBI chr 4:99,503,160...99,547,315
Ensembl chr 4:99,503,176...99,546,905
JBrowse link
G Krt15 keratin 15 increases expression ISO adefovir dipivoxil results in increased expression of KRT15 mRNA CTD PMID:25596134 NCBI chr10:88,046,803...88,050,622
Ensembl chr10:88,046,803...88,050,622
JBrowse link
G Lama3 laminin subunit alpha 3 increases expression ISO adefovir dipivoxil results in increased expression of LAMA3 mRNA CTD PMID:25596134 NCBI chr18:3,704,866...3,941,215
Ensembl chr18:3,705,916...3,940,838
JBrowse link
G Lcn2 lipocalin 2 increases secretion ISO adefovir dipivoxil results in increased secretion of LCN2 protein CTD PMID:24714768 NCBI chr 3:11,414,189...11,417,534
Ensembl chr 3:11,414,186...11,417,546
JBrowse link
G Map3k8 mitogen-activated protein kinase kinase kinase 8 increases expression ISO adefovir dipivoxil results in increased expression of MAP3K8 mRNA CTD PMID:25596134 NCBI chr17:56,109,403...56,129,925
Ensembl chr17:56,109,549...56,129,919
JBrowse link
G Mdm2 MDM2 proto-oncogene increases expression ISO adefovir dipivoxil results in increased expression of MDM2 mRNA CTD PMID:25596134 NCBI chr 7:60,719,060...60,743,618
Ensembl chr 7:60,719,066...60,743,328
JBrowse link
G Mxi1 MAX interactor 1, dimerization protein decreases expression ISO adefovir dipivoxil results in decreased expression of MXI1 mRNA CTD PMID:25596134 NCBI chr 1:274,030,748...274,090,071
Ensembl chr 1:274,030,978...274,090,071
JBrowse link
G Ncapd2 non-SMC condensin I complex, subunit D2 increases expression ISO adefovir dipivoxil results in increased expression of NCAPD2 mRNA CTD PMID:25596134 NCBI chr 4:157,682,855...157,705,903
Ensembl chr 4:157,683,077...157,704,596
JBrowse link
G Ninj1 ninjurin 1 increases expression ISO adefovir dipivoxil results in increased expression of NINJ1 mRNA CTD PMID:25596134 NCBI chr17:15,866,235...15,881,284
Ensembl chr17:15,866,237...15,881,327
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO adefovir dipivoxil inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased activity of NOS2 protein]; adefovir dipivoxil inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; adefovir dipivoxil inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 protein] CTD PMID:9354585 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 decreases expression ISO adefovir dipivoxil results in decreased expression of NQO1 mRNA CTD PMID:25596134 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Nrep neuronal regeneration related protein decreases expression ISO adefovir dipivoxil results in decreased expression of NREP mRNA CTD PMID:25596134 NCBI chr18:26,183,753...26,212,796
Ensembl chr18:26,185,259...26,211,445
JBrowse link
G Ntpcr nucleoside-triphosphatase, cancer-related increases expression ISO adefovir dipivoxil results in increased expression of NTPCR mRNA CTD PMID:25596134 NCBI chr19:58,565,576...58,579,276
Ensembl chr19:58,565,576...58,579,265
JBrowse link
G P4ha1 prolyl 4-hydroxylase subunit alpha 1 decreases expression ISO adefovir dipivoxil results in decreased expression of P4HA1 mRNA CTD PMID:25596134 NCBI chr20:28,920,616...28,972,576
Ensembl chr20:28,920,616...28,971,966
JBrowse link
G Pank1 pantothenate kinase 1 decreases expression ISO adefovir dipivoxil results in decreased expression of PANK1 mRNA CTD PMID:25596134 NCBI chr 1:253,115,400...253,189,643
Ensembl chr 1:253,119,112...253,185,533
JBrowse link
G Pdia5 protein disulfide isomerase family A, member 5 increases expression ISO adefovir dipivoxil results in increased expression of PDIA5 mRNA CTD PMID:25596134 NCBI chr11:68,493,035...68,578,999
Ensembl chr11:68,493,035...68,578,995
JBrowse link
G Pdlim1 PDZ and LIM domain 1 increases expression ISO adefovir dipivoxil results in increased expression of PDLIM1 mRNA CTD PMID:25596134 NCBI chr 1:259,308,326...259,357,006
Ensembl chr 1:259,308,296...259,357,056
JBrowse link
G Pgr progesterone receptor multiple interactions ISO adefovir dipivoxil binds to and results in decreased activity of PGR protein CTD PMID:25752796 NCBI chr 8:7,128,656...7,187,796
Ensembl chr 8:7,128,656...7,187,796
JBrowse link
G Phlda3 pleckstrin homology-like domain, family A, member 3 increases expression ISO adefovir dipivoxil results in increased expression of PHLDA3 mRNA CTD PMID:25596134 NCBI chr13:52,588,917...52,592,002
Ensembl chr13:52,588,917...52,592,001
JBrowse link
G Pidd1 p53-induced death domain protein 1 increases expression ISO adefovir dipivoxil results in increased expression of PIDD1 mRNA CTD PMID:25596134 NCBI chr 1:214,418,751...214,423,959
Ensembl chr 1:214,419,240...214,423,881
JBrowse link
G Pir pirin increases expression ISO adefovir dipivoxil results in increased expression of PIR mRNA CTD PMID:25596134 NCBI chr  X:31,852,322...31,968,152
Ensembl chr  X:31,852,323...31,968,152
JBrowse link
G Plec plectin increases expression ISO adefovir dipivoxil results in increased expression of PLEC mRNA CTD PMID:25596134 NCBI chr 7:117,230,319...117,291,859
Ensembl chr 7:117,230,319...117,289,961
JBrowse link
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 increases expression ISO adefovir dipivoxil results in increased expression of PMAIP1 mRNA CTD PMID:25596134 NCBI chr18:62,159,128...62,179,635
Ensembl chr18:62,174,670...62,181,102
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma affects activity ISO adefovir dipivoxil affects the activity of PPARG protein CTD PMID:25596134 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Ppm1d protein phosphatase, Mg2+/Mn2+ dependent, 1D increases expression ISO adefovir dipivoxil results in increased expression of PPM1D mRNA CTD PMID:25596134 NCBI chr10:72,909,550...72,945,884
Ensembl chr10:72,909,550...72,945,884
JBrowse link
G Prc1 protein regulator of cytokinesis 1 increases expression ISO adefovir dipivoxil results in increased expression of PRC1 mRNA CTD PMID:25596134 NCBI chr 1:142,087,181...142,108,746
Ensembl chr 1:142,087,208...142,108,746
JBrowse link
G Prdm1 PR/SET domain 1 increases expression ISO adefovir dipivoxil results in increased expression of PRDM1 mRNA CTD PMID:25596134 NCBI chr20:49,464,921...49,556,623
Ensembl chr20:49,464,919...49,556,518
JBrowse link
G Prkab2 protein kinase AMP-activated non-catalytic subunit beta 2 decreases expression ISO adefovir dipivoxil results in decreased expression of PRKAB2 mRNA CTD PMID:25596134 NCBI chr 2:199,831,990...199,847,623
Ensembl chr 2:199,831,990...199,847,629
JBrowse link
G Psat1 phosphoserine aminotransferase 1 decreases expression ISO adefovir dipivoxil results in decreased expression of PSAT1 mRNA CTD PMID:25596134 NCBI chr 1:233,124,089...233,145,941
Ensembl chr 1:233,124,092...233,145,941
JBrowse link
G Rara retinoic acid receptor, alpha decreases expression ISO adefovir dipivoxil results in decreased expression of RARA mRNA CTD PMID:25596134 NCBI chr10:86,838,819...86,884,224
Ensembl chr10:86,860,685...86,884,210
JBrowse link
G Rps27l ribosomal protein S27-like increases expression ISO adefovir dipivoxil results in increased expression of RPS27L mRNA CTD PMID:25596134 NCBI chr 8:72,741,155...72,746,090
Ensembl chr 8:72,741,155...72,746,090
JBrowse link
G Rrm2b ribonucleotide reductase regulatory TP53 inducible subunit M2B increases expression ISO adefovir dipivoxil results in increased expression of RRM2B mRNA CTD PMID:25596134 NCBI chr 7:76,750,045...76,780,817
Ensembl chr 7:76,750,050...76,780,817
JBrowse link
G Serpinb5 serpin family B member 5 increases expression ISO adefovir dipivoxil results in increased expression of SERPINB5 mRNA CTD PMID:25596134 NCBI chr13:26,903,052...26,923,250
Ensembl chr13:26,903,052...26,923,250
JBrowse link
G Sesn1 sestrin 1 increases expression ISO adefovir dipivoxil results in increased expression of SESN1 mRNA CTD PMID:25596134 NCBI chr20:46,667,116...46,758,306
Ensembl chr20:46,667,121...46,758,305
JBrowse link
G Sfn stratifin increases expression ISO adefovir dipivoxil results in increased expression of SFN mRNA CTD PMID:25596134 NCBI chr 5:151,823,422...151,824,937
Ensembl chr 5:151,823,887...151,824,633
JBrowse link
G Sh3tc1 SH3 domain and tetratricopeptide repeats 1 decreases expression ISO adefovir dipivoxil results in decreased expression of SH3TC1 mRNA CTD PMID:25596134 NCBI chr14:80,184,814...80,229,207
Ensembl chr14:80,195,715...80,229,214
JBrowse link
G Slc27a2 solute carrier family 27 member 2 decreases expression ISO adefovir dipivoxil results in decreased expression of SLC27A2 mRNA CTD PMID:25596134 NCBI chr 3:119,014,620...119,052,531
Ensembl chr 3:119,014,620...119,052,531
JBrowse link
G Slc6a9 solute carrier family 6 member 9 decreases expression ISO adefovir dipivoxil results in decreased expression of SLC6A9 mRNA CTD PMID:25596134 NCBI chr 5:136,669,674...136,703,702
Ensembl chr 5:136,669,674...136,703,697
JBrowse link
G Slco2b1 solute carrier organic anion transporter family, member 2b1 increases expression ISO adefovir dipivoxil results in increased expression of SLCO2B1 mRNA CTD PMID:25596134 NCBI chr 1:164,623,313...164,671,612
Ensembl chr 1:164,623,599...164,671,577
JBrowse link
G Smap1 small ArfGAP 1 decreases expression ISO adefovir dipivoxil results in decreased expression of SMAP1 mRNA CTD PMID:25596134 NCBI chr 9:30,068,888...30,161,753
Ensembl chr 9:30,068,659...30,161,578
JBrowse link
G Sulf2 sulfatase 2 increases expression ISO adefovir dipivoxil results in increased expression of SULF2 mRNA CTD PMID:25596134 NCBI chr 3:162,791,349...162,872,984
Ensembl chr 3:162,791,355...162,872,831
JBrowse link
G Thra thyroid hormone receptor alpha multiple interactions ISO adefovir dipivoxil binds to and results in decreased activity of THRA protein CTD PMID:25752796 NCBI chr10:86,657,285...86,684,935
Ensembl chr10:86,657,285...86,684,933
JBrowse link
G Tigar TP53 induced glycolysis regulatory phosphatase increases expression ISO adefovir dipivoxil results in increased expression of TIGAR mRNA CTD PMID:25596134 NCBI chr 4:159,635,145...159,654,108
Ensembl chr 4:159,635,153...159,654,063
JBrowse link
G Tiparp TCDD-inducible poly(ADP-ribose) polymerase increases expression ISO adefovir dipivoxil results in increased expression of TIPARP mRNA CTD PMID:25596134 NCBI chr 2:157,316,293...157,342,979
Ensembl chr 2:157,316,266...157,341,469
JBrowse link
G Tnfsf9 TNF superfamily member 9 increases expression ISO adefovir dipivoxil results in increased expression of TNFSF9 mRNA CTD PMID:25596134 NCBI chr 9:9,909,942...9,912,276
Ensembl chr 9:9,909,948...9,912,276
JBrowse link
G Tp53 tumor protein p53 affects activity ISO adefovir dipivoxil affects the activity of TP53 protein CTD PMID:25596134 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Tp53inp1 tumor protein p53 inducible nuclear protein 1 increases expression ISO adefovir dipivoxil results in increased expression of TP53INP1 mRNA CTD PMID:25596134 NCBI chr 5:24,402,895...24,419,651
Ensembl chr 5:24,410,863...24,416,888
JBrowse link
G Trafd1 TRAF type zinc finger domain containing 1 decreases expression ISO adefovir dipivoxil results in decreased expression of TRAFD1 mRNA CTD PMID:25596134 NCBI chr12:40,695,520...40,709,438
Ensembl chr12:40,695,520...40,709,462
JBrowse link
G Triap1 TP53 regulated inhibitor of apoptosis 1 increases expression ISO adefovir dipivoxil results in increased expression of TRIAP1 mRNA CTD PMID:25596134 NCBI chr12:46,987,404...46,989,906
Ensembl chr12:46,987,404...46,989,897
Ensembl chr12:46,987,404...46,989,897
JBrowse link
G Ube2o ubiquitin-conjugating enzyme E2O decreases expression ISO adefovir dipivoxil results in decreased expression of UBE2O mRNA CTD PMID:25596134 NCBI chr10:105,505,721...105,553,167
Ensembl chr10:105,506,955...105,552,986
JBrowse link
G Yars1 tyrosyl-tRNA synthetase 1 decreases expression ISO adefovir dipivoxil results in decreased expression of YARS1 mRNA CTD PMID:25596134 NCBI chr 5:147,375,350...147,403,578
Ensembl chr 5:147,375,350...147,403,571
JBrowse link
G Zmat3 zinc finger, matrin type 3 increases expression ISO adefovir dipivoxil results in increased expression of ZMAT3 mRNA CTD PMID:25596134 NCBI chr 2:118,715,229...118,746,109
Ensembl chr 2:118,721,334...118,745,766
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19816
    role 19764
      biological role 19764
        aetiopathogenetic role 18960
          nephrotoxic agent 928
            adefovir 109
              adefovir pivoxil 100
Path 2
Term Annotations click to browse term
  CHEBI ontology 19816
    subatomic particle 19814
      composite particle 19814
        hadron 19814
          baryon 19814
            nucleon 19814
              atomic nucleus 19814
                atom 19814
                  main group element atom 19702
                    p-block element atom 19702
                      carbon group element atom 19608
                        carbon atom 19597
                          organic molecular entity 19597
                            organic molecule 19522
                              organic cyclic compound 19320
                                organic heterocyclic compound 18432
                                  organic heteropolycyclic compound 17844
                                    organic heterobicyclic compound 16765
                                      imidazopyrimidine 5443
                                        purines 5441
                                          aminopurine 4398
                                            6-aminopurines 782
                                              adenine 776
                                                adefovir 109
                                                  adefovir pivoxil 100
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.