hydroxycinnamic acid - Ontology Report - Rat Genome Database

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CHEBI ONTOLOGY - ANNOTATIONS

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	hydroxycinnamic acid	go back to main search page
Accession:	CHEBI:24689	browse the term
Definition:	Any member of the class of cinnamic acids carrying one or more hydroxy substituents.
Synonyms:	related_synonym:	hydroxycinnamic acids

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Rat (1365) Mouse (1366) Human (1378) Chinchilla (0) Bonobo (0) Dog (0) Squirrel (0) Pig (6) Green Monkey (0) Naked Mole-rat (0) All
Genes (1366)

(-)-bornyl-caffeate

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

BCL2-associated X protein

increases expression

bornyl caffeate results in increased expression of BAX

NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322

G

BCL2-like 2

decreases expression

bornyl caffeate results in decreased expression of BCL2L2

NCBI chr14:55,120,900...55,125,691
Ensembl chr14:55,120,834...55,125,691

G

caspase 3

increases activity

bornyl caffeate results in increased activity of CASP3 protein

NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724

G

poly (ADP-ribose) polymerase family, member 1

increases cleavage

bornyl caffeate results in increased cleavage of PARP1 protein

NCBI chr 1:180,396,456...180,428,564
Ensembl chr 1:180,396,489...180,428,819

acteoside

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

actin alpha 2, smooth muscle, aorta

decreases expression

acteoside results in decreased expression of ACTA2 protein

NCBI chr19:34,217,736...34,232,985
Ensembl chr19:34,218,490...34,232,990

G

advanced glycosylation end product-specific receptor

decreases expression

acteoside results in decreased expression of AGER protein

NCBI chr17:34,816,545...34,819,911
Ensembl chr17:34,816,836...34,819,910

G

aryl-hydrocarbon receptor

decreases localization
multiple interactions

acteoside results in decreased localization of AHR protein
acteoside promotes the reaction [6-formylindolo(3,2-b)carbazole results in increased localization of AHR protein]

NCBI chr12:35,547,978...35,584,988
Ensembl chr12:35,547,973...35,585,037

G

aryl hydrocarbon receptor nuclear translocator

increases localization

acteoside results in increased localization of ARNT protein

NCBI chr 3:95,341,674...95,404,551
Ensembl chr 3:95,341,699...95,404,551

G

C-C motif chemokine ligand 2

decreases secretion
multiple interactions
decreases expression

acteoside results in decreased secretion of CCL2 protein
acteoside inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CCL2 mRNA]
acteoside results in decreased expression of CCL2 mRNA

PMID:21756928 PMID:21967610

NCBI chr11:81,926,403...81,928,278
Ensembl chr11:81,926,397...81,928,279

G

cyclin D1

decreases expression

acteoside results in decreased expression of CCND1 protein

NCBI chr 7:144,483,668...144,493,568
Ensembl chr 7:144,483,668...144,493,662

G

cyclin D2

decreases expression

acteoside results in decreased expression of CCND2 protein

NCBI chr 6:127,102,125...127,131,913
Ensembl chr 6:127,102,125...127,129,156

G

cyclin D3

decreases expression

acteoside results in decreased expression of CCND3 protein

NCBI chr17:47,815,976...47,910,614
Ensembl chr17:47,815,976...47,910,616

G

cyclin E1

decreases expression

acteoside results in decreased expression of CCNE1 protein

NCBI chr 7:37,797,409...37,806,915
Ensembl chr 7:37,797,409...37,806,959

G

cadherin 1

increases expression

acteoside results in increased expression of CDH1 protein

NCBI chr 8:107,329,982...107,396,879
Ensembl chr 8:107,329,983...107,396,878

G

cyclin dependent kinase 2

multiple interactions

acteoside results in decreased expression of and results in decreased activity of CDK2 protein

NCBI chr10:128,533,807...128,540,920
Ensembl chr10:128,533,808...128,540,900

G

cyclin dependent kinase 4

multiple interactions
decreases activity

acteoside promotes the reaction [CDKN1A protein binds to CDK4 protein]; acteoside promotes the reaction [CDKN1B protein binds to CDK4 protein]
acteoside results in decreased activity of CDK4 protein

NCBI chr10:126,899,404...126,903,157
Ensembl chr10:126,899,403...126,903,789

G

cyclin dependent kinase 6

multiple interactions

acteoside promotes the reaction [CDKN1A protein binds to CDK6 protein]; acteoside promotes the reaction [CDKN1B protein binds to CDK6 protein]; acteoside results in decreased expression of and results in decreased activity of CDK6 protein

NCBI chr 5:3,391,004...3,581,008
Ensembl chr 5:3,391,485...3,581,008

G

cyclin dependent kinase inhibitor 1A

multiple interactions
increases expression

acteoside promotes the reaction [CDKN1A protein binds to CDK4 protein]; acteoside promotes the reaction [CDKN1A protein binds to CDK6 protein]
acteoside results in increased expression of CDKN1A mRNA; acteoside results in increased expression of CDKN1A protein

NCBI chr17:29,309,953...29,319,696
Ensembl chr17:29,309,950...29,319,701

G

cyclin dependent kinase inhibitor 1B

multiple interactions
increases expression

acteoside promotes the reaction [CDKN1B protein binds to CDK4 protein]; acteoside promotes the reaction [CDKN1B protein binds to CDK6 protein]
acteoside results in increased expression of CDKN1B mRNA; acteoside results in increased expression of CDKN1B protein

NCBI chr 6:134,897,364...134,902,488
Ensembl chr 6:134,897,364...134,902,476

G

C-X-C motif chemokine ligand 10

decreases secretion
decreases expression
multiple interactions

acteoside results in decreased secretion of CXCL10 protein
acteoside results in decreased expression of CXCL10 mRNA
acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased secretion of CXCL10 protein]; acteoside inhibits the reaction [PD168393 results in increased secretion of CXCL10 protein]; acteoside promotes the reaction [leptomycin B results in decreased secretion of CXCL10 protein]

PMID:21756928 PMID:21967610

NCBI chr 5:92,494,497...92,496,748
Ensembl chr 5:92,494,497...92,496,748

G

C-X-C motif chemokine ligand 15

multiple interactions
decreases expression
decreases secretion

[acteoside co-treated with TGFA protein] results in increased expression of CXCL8 mRNA; acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased secretion of CXCL8 protein]; acteoside inhibits the reaction [leptomycin B results in increased secretion of CXCL8 protein]; acteoside inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CXCL8 mRNA]
acteoside results in decreased expression of CXCL8 mRNA
acteoside results in decreased secretion of CXCL8 protein

PMID:21371465 PMID:21756928 PMID:21967610 PMID:23527233

NCBI chr 5:90,942,393...90,950,926
Ensembl chr 5:90,942,393...90,950,926

G

cytochrome P450, family 1, subfamily a, polypeptide 1

increases expression

acteoside results in increased expression of CYP1A1 mRNA

NCBI chr 9:57,595,211...57,611,107
Ensembl chr 9:57,595,211...57,611,107

G

cytochrome P450, family 2, subfamily e, polypeptide 1

multiple interactions

acteoside inhibits the reaction [Carbon Tetrachloride results in increased expression of and results in increased activity of CYP2E1 protein]

NCBI chr 7:140,343,732...140,354,903
Ensembl chr 7:140,343,652...140,354,900

G

E2F transcription factor 1

multiple interactions

[acteoside results in decreased phosphorylation of RB1 protein] promotes the reaction [RB1 protein binds to E2F1 protein]

NCBI chr 2:154,401,320...154,411,812
Ensembl chr 2:154,401,327...154,411,812

G

epidermal growth factor receptor

decreases phosphorylation
multiple interactions

acteoside results in decreased phosphorylation of EGFR protein
acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of EGFR protein]; acteoside promotes the reaction [TGFA protein affects the localization of EGFR protein modified form]; acteoside promotes the reaction [TGFA protein affects the localization of EGFR protein]

PMID:21756928 PMID:21967610

NCBI chr11:16,700,153...16,868,158
Ensembl chr11:16,702,203...16,868,158

G

high mobility group box 1

decreases expression

acteoside results in decreased expression of HMGB1 protein

NCBI chr 5:148,983,512...148,989,867
Ensembl chr 5:148,983,512...149,121,299

G

intercellular adhesion molecule 1

decreases expression

acteoside results in decreased expression of ICAM1 mRNA

NCBI chr 9:20,927,236...20,940,110
Ensembl chr 9:20,927,281...20,940,113

G

interferon gamma

multiple interactions
decreases expression

acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of EGFR protein]; acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of MAPK1 protein]; acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of MAPK3 protein]; acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of RELA protein]; acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased secretion of CXCL10 protein]; acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased secretion of CXCL8 protein]
acteoside results in decreased expression of IFNG mRNA

PMID:21371465 PMID:21756928

NCBI chr10:118,276,951...118,281,799
Ensembl chr10:118,276,951...118,281,797

G

interleukin 6

multiple interactions
decreases expression

acteoside inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL6 mRNA]
acteoside results in decreased expression of IL6 mRNA

NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979

G

integrin beta 2

multiple interactions

acteoside inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of ITGB2 protein]; acteoside inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ITGB2 protein]

NCBI chr10:77,366,164...77,401,542
Ensembl chr10:77,366,086...77,401,542

G

mitogen-activated protein kinase 1

increases phosphorylation
multiple interactions
decreases phosphorylation

acteoside results in increased phosphorylation of MAPK1 protein
acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of MAPK1 protein]
acteoside results in decreased phosphorylation of MAPK1 protein

PMID:21756928 PMID:23527233

NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317

G

mitogen-activated protein kinase 3

decreases phosphorylation
multiple interactions
increases phosphorylation

acteoside results in decreased phosphorylation of MAPK3 protein
acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of MAPK3 protein]
acteoside results in increased phosphorylation of MAPK3 protein

PMID:21756928 PMID:23527233

NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991

G

NADPH oxidase 1

decreases activity

acteoside results in decreased activity of NOX1 protein

NCBI chr X:132,987,170...133,038,455
Ensembl chr X:132,987,170...133,122,705

G

prostaglandin D2 synthase (brain)

affects binding

acteoside binds to PTGDS protein

NCBI chr 2:25,356,723...25,360,080
Ensembl chr 2:25,356,721...25,360,058

G

prostaglandin-endoperoxide synthase 2

multiple interactions

[acteoside co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of PTGS2 mRNA

NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978

G

Rac family small GTPase 1

decreases expression

Verbascoside decreases expression of RAC1 mRNA in colon cancer cells

RGD

NCBI chr 5:143,491,236...143,513,786
Ensembl chr 5:143,489,389...143,513,791

G

RB transcriptional corepressor 1

multiple interactions
decreases phosphorylation

[acteoside results in decreased phosphorylation of RB1 protein] promotes the reaction [RB1 protein binds to E2F1 protein]

NCBI chr14:73,430,298...73,563,446
Ensembl chr14:73,421,113...73,563,262

G

v-rel reticuloendotheliosis viral oncogene homolog A (avian)

decreases phosphorylation
multiple interactions
increases phosphorylation

acteoside results in decreased phosphorylation of RELA protein
acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of RELA protein]; acteoside inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of RELA protein]
acteoside results in increased phosphorylation of RELA protein

PMID:21756928 PMID:23527233

NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158

G

SMAD family member 2

increases phosphorylation

acteoside results in increased phosphorylation of SMAD2 protein

NCBI chr18:76,369,898...76,444,819
Ensembl chr18:76,374,651...76,444,034

G

SMAD family member 3

increases phosphorylation

acteoside results in increased phosphorylation of SMAD3 protein

NCBI chr 9:63,554,048...63,665,276
Ensembl chr 9:63,554,049...63,665,276

G

SMAD family member 7

increases expression

acteoside results in increased expression of SMAD7 protein

NCBI chr18:75,500,436...75,529,006
Ensembl chr18:75,500,600...75,529,006

G

snail family zinc finger 1

decreases expression

acteoside results in decreased expression of SNAI1 protein

NCBI chr 2:167,380,115...167,384,734
Ensembl chr 2:167,380,115...167,384,734

G

snail family zinc finger 2

decreases expression

acteoside results in decreased expression of SNAI2 protein

NCBI chr16:14,523,716...14,527,259
Ensembl chr16:14,523,716...14,527,249

G

superoxide dismutase 2, mitochondrial

decreases expression

acteoside results in decreased expression of SOD2 mRNA

NCBI chr17:13,226,726...13,237,006
Ensembl chr17:13,225,733...13,258,950

G

transforming growth factor alpha

multiple interactions

[acteoside co-treated with TGFA protein] results in increased expression of CXCL8 mRNA; acteoside promotes the reaction [TGFA protein affects the localization of EGFR protein modified form]; acteoside promotes the reaction [TGFA protein affects the localization of EGFR protein]

PMID:21756928 PMID:21967610

NCBI chr 6:86,172,020...86,252,726
Ensembl chr 6:86,172,205...86,252,701

G

transforming growth factor, beta 1

increases expression

acteoside results in increased expression of TGFB1 mRNA

NCBI chr 7:25,386,406...25,404,503
Ensembl chr 7:25,386,427...25,404,502

G

transforming growth factor, beta receptor I

decreases expression

acteoside results in decreased expression of TGFBR1 protein

NCBI chr 4:47,353,258...47,414,926
Ensembl chr 4:47,353,222...47,414,931

G

transforming growth factor, beta receptor II

decreases expression

acteoside results in decreased expression of TGFBR2 protein

NCBI chr 9:115,916,763...116,004,431
Ensembl chr 9:115,913,361...116,004,428

G

tumor necrosis factor

multiple interactions

acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of EGFR protein]; acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of MAPK1 protein]; acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of MAPK3 protein]; acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of RELA protein]; acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased secretion of CXCL10 protein]; acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased secretion of CXCL8 protein]

NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983

G

vascular cell adhesion molecule 1

decreases expression

acteoside results in decreased expression of VCAM1 mRNA

NCBI chr 3:115,903,669...115,923,337
Ensembl chr 3:115,903,598...115,923,337

alpha-cyano-4-hydroxycinnamic acid

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

angiotensinogen

multiple interactions

alpha-cyano-4-hydroxycinnamate inhibits the reaction [Glucose results in increased expression of AGT mRNA]; alpha-cyano-4-hydroxycinnamate inhibits the reaction [Glucose results in increased expression of AGT protein]

NCBI chr 8:125,283,326...125,296,445
Ensembl chr 8:125,283,273...125,296,445

G

C-X-C motif chemokine receptor 4

decreases expression

alpha-cyano-4-hydroxycinnamate results in decreased expression of CXCR4 mRNA; alpha-cyano-4-hydroxycinnamate results in decreased expression of CXCR4 protein

NCBI chr 1:128,515,936...128,520,036
Ensembl chr 1:128,515,936...128,520,030

G

fibroblast growth factor 21

multiple interactions

alpha-cyano-4-hydroxycinnamate inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased expression of FGF21 mRNA]

NCBI chr 7:45,263,314...45,264,914
Ensembl chr 7:45,263,310...45,264,914

G

hexokinase 2

decreases expression

alpha-cyano-4-hydroxycinnamate results in decreased expression of HK2 mRNA; alpha-cyano-4-hydroxycinnamate results in decreased expression of HK2 protein

NCBI chr 6:82,702,004...82,751,437
Ensembl chr 6:82,702,006...82,751,435

bisdemethoxycurcumin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP-binding cassette, sub-family C member 1

decreases activity

bisdemethoxycurcumin results in decreased activity of ABCC1 protein; curcumin III results in decreased activity of ABCC1 protein

PMID:15885658 PMID:16021489

NCBI chr16:14,179,317...14,292,743
Ensembl chr16:14,179,422...14,293,601

G

ATP-binding cassette, sub-family member 2

decreases activity

bisdemethoxycurcumin results in decreased activity of ABCC2 protein

NCBI chr19:43,770,747...43,826,771
Ensembl chr19:43,770,631...43,829,179

G

thymoma viral proto-oncogene 1

increases phosphorylation
decreases expression
multiple interactions

bisdemethoxycurcumin results in increased phosphorylation of AKT1 protein
bisdemethoxycurcumin results in decreased expression of AKT1 protein modified form
[bisdemethoxycurcumin co-treated with Curcumin co-treated with demethoxycurcumin] inhibits the reaction [VEGF protein results in increased phosphorylation of AKT1 protein]; bisdemethoxycurcumin inhibits the reaction [VEGF protein results in increased phosphorylation of AKT1 protein]
AKT1 protein affects the reaction [bisdemethoxycurcumin results in increased expression of HMOX1 mRNA]

PMID:17535857 PMID:35735092 PMID:35752269

NCBI chr12:112,620,260...112,641,266
Ensembl chr12:112,620,255...112,641,318

G

amyloid beta precursor protein

multiple interactions

[bisdemethoxycurcumin analog co-treated with APP protein] results in increased expression of MGAT3 mRNA; [bisdemethoxycurcumin analog co-treated with APP protein] results in increased expression of TLR2 mRNA; [bisdemethoxycurcumin analog co-treated with APP protein] results in increased expression of TLR3 mRNA; [bisdemethoxycurcumin analog co-treated with APP protein] results in increased expression of TLR4 mRNA; [bisdemethoxycurcumin analog co-treated with APP protein] results in increased expression of VDR mRNA; [bisdemethoxycurcumin co-treated with APP protein] results in increased expression of MGAT3 mRNA; [bisdemethoxycurcumin co-treated with APP protein] results in increased expression of TLR2 mRNA; [bisdemethoxycurcumin co-treated with APP protein] results in increased expression of TLR3 mRNA; [bisdemethoxycurcumin co-treated with APP protein] results in increased expression of TLR4 mRNA; bisdemethoxycurcumin inhibits the reaction [APP protein binds to APP protein]

PMID:19715544 PMID:22029407

NCBI chr16:84,751,236...84,972,187
Ensembl chr16:84,746,573...84,970,654

G

CD36 molecule

increases expression
multiple interactions

bisdemethoxycurcumin results in increased expression of CD36 mRNA
bisdemethoxycurcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CD36 mRNA]

NCBI chr 5:17,986,680...18,093,828
Ensembl chr 5:17,986,688...18,093,799

G

epidermal growth factor receptor

decreases expression

bisdemethoxycurcumin results in decreased expression of EGFR protein modified form

NCBI chr11:16,700,153...16,868,158
Ensembl chr11:16,702,203...16,868,158

G

erb-b2 receptor tyrosine kinase 2

decreases expression
increases response to substance

bisdemethoxycurcumin results in decreased expression of ERBB2 protein
ERBB2 protein results in increased susceptibility to bisdemethoxycurcumin

NCBI chr11:98,303,310...98,328,542
Ensembl chr11:98,303,296...98,328,542

G

glutamate-cysteine ligase, modifier subunit

increases expression

bisdemethoxycurcumin results in increased expression of GCLM mRNA; bisdemethoxycurcumin results in increased expression of GCLM protein

PMID:17535857 PMID:19188863

NCBI chr 3:122,039,206...122,060,864
Ensembl chr 3:122,039,206...122,064,381

G

growth factor receptor bound protein 2

decreases expression

bisdemethoxycurcumin results in decreased expression of GRB2 protein

NCBI chr11:115,534,871...115,599,423
Ensembl chr11:115,534,871...115,599,423

G

heme oxygenase 1

increases expression
multiple interactions

bisdemethoxycurcumin results in increased expression of HMOX1 mRNA; bisdemethoxycurcumin results in increased expression of HMOX1 protein
[demethoxycurcumin co-treated with bisdemethoxycurcumin] results in increased expression of HMOX1 mRNA; AKT1 protein affects the reaction [bisdemethoxycurcumin results in increased expression of HMOX1 mRNA]; KEAP1 protein inhibits the reaction [bisdemethoxycurcumin results in increased expression of HMOX1 mRNA]; NFE2L2 protein affects the reaction [bisdemethoxycurcumin results in increased expression of HMOX1 mRNA]; PRKCD protein affects the reaction [bisdemethoxycurcumin results in increased expression of HMOX1 mRNA]; rottlerin inhibits the reaction [bisdemethoxycurcumin results in increased expression of HMOX1 mRNA]; rottlerin inhibits the reaction [bisdemethoxycurcumin results in increased expression of HMOX1 protein]; Wortmannin inhibits the reaction [bisdemethoxycurcumin results in increased expression of HMOX1 mRNA]; Wortmannin inhibits the reaction [bisdemethoxycurcumin results in increased expression of HMOX1 protein]

PMID:17535857 PMID:19188863 PMID:23386263

NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217

G

kinase insert domain protein receptor

multiple interactions

[bisdemethoxycurcumin co-treated with Curcumin co-treated with demethoxycurcumin] inhibits the reaction [VEGF protein results in increased phosphorylation of KDR protein]; bisdemethoxycurcumin inhibits the reaction [VEGF protein results in increased phosphorylation of KDR protein]

NCBI chr 5:76,093,487...76,139,880
Ensembl chr 5:76,093,487...76,139,118

G

kelch-like ECH-associated protein 1

multiple interactions

KEAP1 protein inhibits the reaction [bisdemethoxycurcumin results in increased expression of HMOX1 mRNA]

NCBI chr 9:21,141,026...21,150,628
Ensembl chr 9:21,141,026...21,150,657

G

mitogen-activated protein kinase 1

increases phosphorylation
decreases expression
multiple interactions

bisdemethoxycurcumin results in increased phosphorylation of MAPK1 protein
bisdemethoxycurcumin results in decreased expression of MAPK1 protein modified form
[bisdemethoxycurcumin co-treated with Curcumin co-treated with demethoxycurcumin] inhibits the reaction [VEGF protein results in increased phosphorylation of MAPK1 protein]; bisdemethoxycurcumin inhibits the reaction [VEGF protein results in increased phosphorylation of MAPK1 protein]

PMID:17535857 PMID:35735092 PMID:35752269

NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317

G

mitogen-activated protein kinase 3

increases phosphorylation
decreases expression
multiple interactions

bisdemethoxycurcumin results in increased phosphorylation of MAPK3 protein
bisdemethoxycurcumin results in decreased expression of MAPK3 protein modified form
[bisdemethoxycurcumin co-treated with Curcumin co-treated with demethoxycurcumin] inhibits the reaction [VEGF protein results in increased phosphorylation of MAPK3 protein]; bisdemethoxycurcumin inhibits the reaction [VEGF protein results in increased phosphorylation of MAPK3 protein]

PMID:17535857 PMID:35735092 PMID:35752269

NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991

G

mannoside acetylglucosaminyltransferase 3

multiple interactions
increases expression

[bisdemethoxycurcumin analog co-treated with APP protein] results in increased expression of MGAT3 mRNA; [bisdemethoxycurcumin co-treated with APP protein] results in increased expression of MGAT3 mRNA
bisdemethoxycurcumin results in increased expression of MGAT3 mRNA

PMID:19090986 PMID:22029407

NCBI chr15:80,057,852...80,099,720
Ensembl chr15:80,057,922...80,099,720

G

matrix metallopeptidase 14 (membrane-inserted)

decreases expression

bisdemethoxycurcumin results in decreased expression of MMP14 protein

NCBI chr14:54,669,055...54,679,913
Ensembl chr14:54,669,069...54,682,821

G

matrix metallopeptidase 2

multiple interactions
decreases expression

bisdemethoxycurcumin results in decreased secretion of and results in decreased activity of MMP2 protein modified form
bisdemethoxycurcumin results in decreased expression of MMP2 protein

PMID:18495463 PMID:35735092

NCBI chr 8:93,553,920...93,580,049
Ensembl chr 8:93,553,919...93,580,048

G

matrix metallopeptidase 9

multiple interactions
decreases expression

bisdemethoxycurcumin results in decreased secretion of and results in decreased activity of MMP9 protein
bisdemethoxycurcumin results in decreased expression of MMP9 protein

PMID:18495463 PMID:35735092

NCBI chr 2:164,782,246...164,797,770
Ensembl chr 2:164,782,700...164,797,770

G

macrophage scavenger receptor 1

multiple interactions

bisdemethoxycurcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MSR1 mRNA]

NCBI chr 8:39,996,284...40,095,790
Ensembl chr 8:40,034,726...40,095,714

G

nuclear factor, erythroid derived 2, like 2

affects localization
multiple interactions

bisdemethoxycurcumin affects the localization of NFE2L2 protein
[demethoxycurcumin co-treated with bisdemethoxycurcumin] affects the localization of NFE2L2 protein; NFE2L2 protein affects the reaction [bisdemethoxycurcumin results in increased expression of HMOX1 mRNA]

NCBI chr 2:75,505,860...75,535,007
Ensembl chr 2:75,505,857...75,534,985

G

nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha

multiple interactions

bisdemethoxycurcumin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased degradation of NFKBIA protein]

NCBI chr12:55,536,194...55,539,432
Ensembl chr12:55,536,195...55,539,432

G

nitric oxide synthase 2, inducible

multiple interactions

bisdemethoxycurcumin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; bisdemethoxycurcumin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]

PMID:18449507 PMID:18481332 PMID:18838107 PMID:19188055

NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080

G

NAD(P)H dehydrogenase, quinone 1

increases expression

bisdemethoxycurcumin results in increased expression of NQO1 mRNA; bisdemethoxycurcumin results in increased expression of NQO1 protein

PMID:17535857 PMID:19188863

NCBI chr 8:108,114,856...108,139,012
Ensembl chr 8:108,114,857...108,129,838

G

3-phosphoinositide dependent protein kinase 1

decreases expression

bisdemethoxycurcumin results in decreased expression of PDPK1 protein modified form

NCBI chr17:24,292,654...24,370,957
Ensembl chr17:24,292,654...24,369,898

G

plasminogen activator, urokinase

decreases secretion

bisdemethoxycurcumin results in decreased secretion of PLAU protein

NCBI chr14:20,886,730...20,893,456
Ensembl chr14:20,886,728...20,893,453

G

peroxisome proliferator activated receptor gamma

affects binding

bisdemethoxycurcumin binds to PPARG protein

NCBI chr 6:115,337,828...115,467,365
Ensembl chr 6:115,337,912...115,467,360

G

protein kinase C, delta

multiple interactions

PRKCD protein affects the reaction [bisdemethoxycurcumin results in increased expression of HMOX1 mRNA]

NCBI chr14:30,317,310...30,348,637
Ensembl chr14:30,317,311...30,348,167

G

prostaglandin-endoperoxide synthase 2

multiple interactions

bisdemethoxycurcumin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; bisdemethoxycurcumin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]

NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978

G

v-raf-leukemia viral oncogene 1

decreases expression

bisdemethoxycurcumin results in decreased expression of RAF1 protein modified form

NCBI chr 6:115,595,530...115,653,596
Ensembl chr 6:115,595,028...115,653,596

G

SOS Ras/Rac guanine nucleotide exchange factor 1

decreases expression

bisdemethoxycurcumin results in decreased expression of SOS1 protein

NCBI chr17:80,701,181...80,787,882
Ensembl chr17:80,701,180...80,787,882

G

tissue inhibitor of metalloproteinase 1

decreases expression

bisdemethoxycurcumin results in decreased expression of TIMP1 protein

NCBI chr X:20,736,524...20,740,972
Ensembl chr X:20,736,405...20,740,974

G

tissue inhibitor of metalloproteinase 2

decreases expression

bisdemethoxycurcumin results in decreased expression of TIMP2 protein

NCBI chr11:118,191,887...118,246,237
Ensembl chr11:118,191,887...118,246,566

G

toll-like receptor 2

multiple interactions

[bisdemethoxycurcumin analog co-treated with APP protein] results in increased expression of TLR2 mRNA; [bisdemethoxycurcumin co-treated with APP protein] results in increased expression of TLR2 mRNA

NCBI chr 3:83,743,579...83,749,045
Ensembl chr 3:83,743,579...83,749,074

G

toll-like receptor 3

multiple interactions

[bisdemethoxycurcumin analog co-treated with APP protein] results in increased expression of TLR3 mRNA; [bisdemethoxycurcumin co-treated with APP protein] results in increased expression of TLR3 mRNA

NCBI chr 8:45,848,702...45,864,112
Ensembl chr 8:45,848,702...45,864,117

G

toll-like receptor 4

multiple interactions

[bisdemethoxycurcumin analog co-treated with APP protein] results in increased expression of TLR4 mRNA; [bisdemethoxycurcumin co-treated with APP protein] results in increased expression of TLR4 mRNA

NCBI chr 4:66,745,788...66,765,338
Ensembl chr 4:66,745,821...66,848,521

G

tumor necrosis factor

multiple interactions

bisdemethoxycurcumin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; bisdemethoxycurcumin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]

NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983

G

vitamin D (1,25-dihydroxyvitamin D3) receptor

multiple interactions

[bisdemethoxycurcumin analog co-treated with APP protein] results in increased expression of VDR mRNA

NCBI chr15:97,752,308...97,806,177
Ensembl chr15:97,752,306...97,808,511

G

vascular endothelial growth factor A

multiple interactions

[bisdemethoxycurcumin co-treated with Curcumin co-treated with demethoxycurcumin] inhibits the reaction [VEGF protein results in increased phosphorylation of AKT1 protein]; [bisdemethoxycurcumin co-treated with Curcumin co-treated with demethoxycurcumin] inhibits the reaction [VEGF protein results in increased phosphorylation of KDR protein]; [bisdemethoxycurcumin co-treated with Curcumin co-treated with demethoxycurcumin] inhibits the reaction [VEGF protein results in increased phosphorylation of MAPK1 protein]; [bisdemethoxycurcumin co-treated with Curcumin co-treated with demethoxycurcumin] inhibits the reaction [VEGF protein results in increased phosphorylation of MAPK3 protein]; bisdemethoxycurcumin inhibits the reaction [VEGF protein results in increased phosphorylation of AKT1 protein]; bisdemethoxycurcumin inhibits the reaction [VEGF protein results in increased phosphorylation of KDR protein]; bisdemethoxycurcumin inhibits the reaction [VEGF protein results in increased phosphorylation of MAPK1 protein]; bisdemethoxycurcumin inhibits the reaction [VEGF protein results in increased phosphorylation of MAPK3 protein]

NCBI chr17:46,327,919...46,343,303
Ensembl chr17:46,327,919...46,343,295

G

WT1 transcription factor

decreases expression

bisdemethoxycurcumin results in decreased expression of WT1 mRNA; bisdemethoxycurcumin results in decreased expression of WT1 protein

NCBI chr 2:104,956,874...105,003,959
Ensembl chr 2:104,956,874...105,003,961

chlorogenic acid

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP-binding cassette, sub-family C member 1

multiple interactions

Chlorogenic Acid inhibits the reaction [Cisplatin results in increased expression of ABCC1 protein]

NCBI chr16:14,179,317...14,292,743
Ensembl chr16:14,179,422...14,293,601

G

ATP-binding cassette, sub-family member 2

multiple interactions

Chlorogenic Acid inhibits the reaction [Cisplatin results in increased expression of ABCC2 protein]

NCBI chr19:43,770,747...43,826,771
Ensembl chr19:43,770,631...43,829,179

G

acetylcholinesterase

decreases activity

Chlorogenic Acid results in decreased activity of ACHE protein

NCBI chr 5:137,286,516...137,292,728
Ensembl chr 5:137,285,781...137,292,728

G

ATP citrate lyase

increases expression

Chlorogenic Acid results in increased expression of ACLY mRNA

NCBI chr11:100,367,178...100,418,826
Ensembl chr11:100,367,179...100,418,826

G

actin alpha 2, smooth muscle, aorta

multiple interactions

Chlorogenic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 mRNA]; Chlorogenic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein]

NCBI chr19:34,217,736...34,232,985
Ensembl chr19:34,218,490...34,232,990

G

thymoma viral proto-oncogene 1

multiple interactions

Chlorogenic Acid inhibits the reaction [Rotenone results in decreased phosphorylation of AKT1 protein]

NCBI chr12:112,620,260...112,641,266
Ensembl chr12:112,620,255...112,641,318

G

albumin

multiple interactions

Chlorogenic Acid inhibits the reaction [Carbon Tetrachloride results in decreased expression of ALB protein]
Chlorogenic Acid affects the reaction [2,2'-azobis(2-amidinopropane) results in increased degradation of ALB protein]

PMID:11322927 PMID:23146752

NCBI chr 5:90,608,729...90,624,461
Ensembl chr 5:90,608,756...90,624,461

G

aquaporin 1

increases expression

Chlorogenic Acid results in increased expression of AQP1 mRNA

NCBI chr 6:55,313,284...55,325,540
Ensembl chr 6:55,313,417...55,325,540

G

aquaporin 3

increases expression

Chlorogenic Acid results in increased expression of AQP3 mRNA

NCBI chr 4:41,092,724...41,098,183
Ensembl chr 4:41,092,722...41,098,183

G

androgen receptor

decreases expression

Chlorogenic Acid results in decreased expression of AR mRNA

NCBI chr X:97,192,363...97,366,824
Ensembl chr X:97,192,375...97,366,821

G

activating transcription factor 4

multiple interactions

Chlorogenic Acid inhibits the reaction [Glucose results in increased expression of ATF4 protein]

NCBI chr15:80,139,385...80,141,746
Ensembl chr15:80,139,385...80,141,742

G

activating transcription factor 6

multiple interactions

Chlorogenic Acid inhibits the reaction [[Streptozocin co-treated with Dietary Fats co-treated with Fructose] results in increased expression of ATF6 protein]; Chlorogenic Acid inhibits the reaction [Glucose results in increased expression of ATF6 protein]

NCBI chr 1:170,532,026...170,696,414
Ensembl chr 1:170,532,243...170,695,340

G

BMP and activin membrane-bound inhibitor

multiple interactions

Chlorogenic Acid inhibits the reaction [Carbon Tetrachloride results in decreased expression of BAMBI mRNA]; Chlorogenic Acid inhibits the reaction [Carbon Tetrachloride results in decreased expression of BAMBI protein]

NCBI chr18:3,507,011...3,516,404
Ensembl chr18:3,507,923...3,516,404

G

BCL2-associated X protein

multiple interactions
increases expression

Chlorogenic Acid inhibits the reaction [Aluminum Chloride results in increased expression of BAX protein]; Chlorogenic Acid inhibits the reaction [Cisplatin results in increased expression of BAX protein]; Chlorogenic Acid inhibits the reaction [sodium arsenite results in increased expression of BAX mRNA]
Chlorogenic Acid results in increased expression of BAX mRNA; Chlorogenic Acid results in increased expression of BAX protein
Chlorogenic Acid inhibits the reaction [Methotrexate results in increased expression of BAX protein]

PMID:25043994 PMID:28479099 PMID:28623112 PMID:33058431 PMID:33242462

NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322

G

B cell leukemia/lymphoma 2

multiple interactions
decreases expression

Chlorogenic Acid inhibits the reaction [Aluminum Chloride results in decreased expression of BCL2 protein]; Chlorogenic Acid inhibits the reaction [sodium arsenite results in decreased expression of BCL2 mRNA]
Chlorogenic Acid results in decreased expression of BCL2 mRNA; Chlorogenic Acid results in decreased expression of BCL2 protein
Chlorogenic Acid inhibits the reaction [Glucose results in decreased expression of BCL2 protein]; Chlorogenic Acid inhibits the reaction [Methotrexate results in decreased expression of BCL2 protein]

PMID:28479099 PMID:28623112 PMID:33058431 PMID:33242462 PMID:34801538

NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004

G

calnexin

multiple interactions

Chlorogenic Acid inhibits the reaction [[Streptozocin co-treated with Dietary Fats co-treated with Fructose] results in increased expression of CANX protein]; Chlorogenic Acid inhibits the reaction [Glucose results in increased expression of CANX protein]

NCBI chr11:50,184,784...50,216,500
Ensembl chr11:50,184,788...50,216,500

G

caspase 12

multiple interactions

Chlorogenic Acid inhibits the reaction [Glucose results in increased expression of CASP12 protein]

NCBI chr 9:5,345,419...5,373,034
Ensembl chr 9:5,345,430...5,373,032

G

caspase 3

multiple interactions
increases expression

Chlorogenic Acid inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein]; Chlorogenic Acid inhibits the reaction [sodium arsenite results in increased expression of CASP3 mRNA]; Chlorogenic Acid inhibits the reaction [sodium arsenite results in increased expression of CASP3 protein]
Chlorogenic Acid results in increased expression of CASP3 mRNA
Chlorogenic Acid inhibits the reaction [Glucose results in increased activity of CASP3 protein]; Chlorogenic Acid inhibits the reaction [Methotrexate results in increased activity of CASP3 protein]

PMID:25043994 PMID:28479099 PMID:33058431 PMID:33242462 PMID:34801538

NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724

G

caspase 8

multiple interactions

Chlorogenic Acid inhibits the reaction [aluminum chloride results in increased expression of CASP8 protein]

NCBI chr 1:58,834,553...58,886,663
Ensembl chr 1:58,834,533...58,886,662

G

caspase 9

multiple interactions

Chlorogenic Acid inhibits the reaction [Methotrexate results in increased activity of CASP9 protein]

NCBI chr 4:141,520,923...141,543,289
Ensembl chr 4:141,520,923...141,543,287

G

catalase

multiple interactions

Chlorogenic Acid inhibits the reaction [Aluminum Chloride results in decreased activity of CAT protein]; Chlorogenic Acid inhibits the reaction [sodium arsenite results in decreased activity of CAT protein]; Chlorogenic Acid inhibits the reaction [sodium arsenite results in decreased expression of CAT mRNA]
Chlorogenic Acid inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased activity of CAT protein]; Chlorogenic Acid inhibits the reaction [Methotrexate results in decreased activity of CAT protein]

PMID:28479099 PMID:28623112 PMID:31390532 PMID:33242462

NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505

G

C-C motif chemokine ligand 2

multiple interactions

Chlorogenic Acid inhibits the reaction [Acetaminophen results in increased expression of CCL2 mRNA]; Chlorogenic Acid inhibits the reaction [Acetaminophen results in increased secretion of CCL2 protein]; Chlorogenic Acid inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL2 protein]

PMID:26079055 PMID:31306686

NCBI chr11:81,926,403...81,928,278
Ensembl chr11:81,926,397...81,928,279

G

cyclin D1

multiple interactions

Chlorogenic Acid inhibits the reaction [Cisplatin results in increased expression of CCND1 protein]

NCBI chr 7:144,483,668...144,493,568
Ensembl chr 7:144,483,668...144,493,662

G

CD44 antigen

increases expression

Chlorogenic Acid results in increased expression of CD44 mRNA

NCBI chr 2:102,641,486...102,732,014
Ensembl chr 2:102,641,486...102,732,010

G

cadherin 1

increases expression

Chlorogenic Acid results in increased expression of CDH1 mRNA

NCBI chr 8:107,329,982...107,396,879
Ensembl chr 8:107,329,983...107,396,878

G

collagen, type I, alpha 1

increases expression
multiple interactions

Chlorogenic Acid results in increased expression of COL1A1 mRNA
Chlorogenic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of COL1A1 mRNA]

PMID:20706672 PMID:23146752

NCBI chr11:94,827,050...94,843,868
Ensembl chr11:94,827,050...94,843,868

G

collagen, type II, alpha 1

multiple interactions

[geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in decreased abundance of Amino Acids]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in decreased abundance of Pantothenic Acid]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in decreased abundance of phenylpyruvic acid]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Allantoin]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Amino Acids]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Carnitine]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Citric Acid]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Creatine]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Creatinine]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of phenylacetylglycine]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Succinic Acid]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Uric Acid]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Uridine]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased secretion of IL1B protein]

NCBI chr15:97,873,483...97,902,525
Ensembl chr15:97,873,483...97,902,576

G

citrate synthase

increases activity

Chlorogenic Acid results in increased activity of CS protein

NCBI chr10:128,173,596...128,198,351
Ensembl chr10:128,173,603...128,198,348

G

C-X-C motif chemokine ligand 3

multiple interactions

Chlorogenic Acid inhibits the reaction [Acetaminophen results in increased expression of CXCL1 mRNA]; Chlorogenic Acid inhibits the reaction [Acetaminophen results in increased secretion of CXCL1 protein]

NCBI chr 5:90,933,960...90,935,952
Ensembl chr 5:90,933,962...90,937,459

G

cytoglobin

decreases expression

Chlorogenic Acid results in decreased expression of CYGB mRNA

NCBI chr11:116,536,421...116,544,887
Ensembl chr11:116,536,421...116,545,139

G

cytochrome P450, family 19, subfamily a, polypeptide 1

increases expression

Chlorogenic Acid results in increased expression of CYP19A1 protein

NCBI chr 9:54,073,221...54,175,448
Ensembl chr 9:54,073,221...54,175,394

G

cytochrome P450, family 2, subfamily e, polypeptide 1

multiple interactions

Chlorogenic Acid inhibits the reaction [Cisplatin results in increased expression of CYP2E1 protein]

NCBI chr 7:140,343,732...140,354,903
Ensembl chr 7:140,343,652...140,354,900

G

DNA-damage inducible transcript 3

multiple interactions

Chlorogenic Acid inhibits the reaction [[Streptozocin co-treated with Dietary Fats co-treated with Fructose] results in increased expression of DDIT3 protein]; Chlorogenic Acid inhibits the reaction [Glucose results in increased expression of DDIT3 protein]

NCBI chr10:127,126,662...127,132,160
Ensembl chr10:127,126,643...127,132,157
Ensembl chr10:127,126,643...127,132,157

G

desmoglein 3

decreases expression

Chlorogenic Acid results in decreased expression of DSG3 mRNA

NCBI chr18:20,643,331...20,674,367
Ensembl chr18:20,643,331...20,680,516

G

epidermal growth factor

decreases expression

Chlorogenic Acid results in decreased expression of EGF mRNA

NCBI chr 3:129,471,223...129,548,971
Ensembl chr 3:129,471,214...129,548,965

G

eukaryotic translation initiation factor 2 alpha kinase 3

multiple interactions

Chlorogenic Acid inhibits the reaction [[Streptozocin co-treated with Dietary Fats co-treated with Fructose] results in increased expression of EIF2AK3 protein]; Chlorogenic Acid inhibits the reaction [Glucose results in increased phosphorylation of EIF2AK3 protein]

NCBI chr 6:70,821,468...70,882,225
Ensembl chr 6:70,821,499...70,882,229

G

eukaryotic translation initiation factor 2, subunit 1 alpha

multiple interactions

Chlorogenic Acid inhibits the reaction [Glucose results in increased phosphorylation of EIF2S1 protein]

NCBI chr12:78,908,846...78,933,784
Ensembl chr12:78,908,593...78,933,784

G

endoplasmic reticulum to nucleus signalling 1

multiple interactions

Chlorogenic Acid inhibits the reaction [[Streptozocin co-treated with Dietary Fats co-treated with Fructose] results in increased expression of ERN1 protein]; Chlorogenic Acid inhibits the reaction [Glucose results in increased phosphorylation of ERN1 protein]

NCBI chr11:106,285,474...106,378,701
Ensembl chr11:106,285,476...106,378,678

G

endoplasmic reticulum oxidoreductase 1 alpha

multiple interactions

Chlorogenic Acid inhibits the reaction [Glucose results in increased expression of ERO1A protein]

NCBI chr14:45,520,544...45,556,029
Ensembl chr14:45,520,544...45,556,228

G

estrogen receptor 1 (alpha)

decreases expression

Chlorogenic Acid results in decreased expression of ESR1 protein

NCBI chr10:4,561,989...4,955,633
Ensembl chr10:4,561,593...4,955,614

G

estrogen receptor 2 (beta)

increases expression

Chlorogenic Acid results in increased expression of ESR2 protein

NCBI chr12:76,167,193...76,224,033
Ensembl chr12:76,167,193...76,224,033

G

coagulation factor X

decreases activity

Chlorogenic Acid results in decreased activity of F10 protein

NCBI chr 8:13,087,308...13,106,676
Ensembl chr 8:13,087,308...13,106,676

G

coagulation factor II

decreases activity

Chlorogenic Acid results in decreased activity of F2 protein

NCBI chr 2:91,442,742...91,466,799
Ensembl chr 2:91,455,665...91,466,759

G

fatty acid synthase

decreases expression

Chlorogenic Acid results in decreased expression of FASN mRNA

NCBI chr11:120,696,784...120,715,992
Ensembl chr11:120,696,672...120,715,373

G

fibrillin 1

decreases expression

Chlorogenic Acid results in decreased expression of FBN1 mRNA

NCBI chr 2:125,142,514...125,348,417
Ensembl chr 2:125,142,514...125,349,913

G

fibrillin 2

decreases expression

Chlorogenic Acid results in decreased expression of FBN2 mRNA

NCBI chr18:58,141,689...58,343,200
Ensembl chr18:58,141,695...58,343,559

G

free fatty acid receptor 1

multiple interactions

Chlorogenic Acid inhibits the reaction [Rotenone results in decreased expression of FFAR1 mRNA]

NCBI chr 7:30,559,993...30,560,895
Ensembl chr 7:30,556,815...30,560,989

G

free fatty acid receptor 2

multiple interactions

Chlorogenic Acid inhibits the reaction [Rotenone results in decreased expression of FFAR2 mRNA]

NCBI chr 7:30,517,778...30,523,200
Ensembl chr 7:30,517,773...30,523,200

G

fibroblast growth factor 1

increases expression

Chlorogenic Acid results in increased expression of FGF1 mRNA

NCBI chr18:38,971,725...39,062,532
Ensembl chr18:38,971,726...39,062,525

G

follicle stimulating hormone beta

multiple interactions

Chlorogenic Acid inhibits the reaction [sodium arsenite results in decreased expression of FSHB protein]

NCBI chr 2:106,886,331...106,889,996
Ensembl chr 2:106,886,485...106,890,001

G

follicle stimulating hormone receptor

increases expression

Chlorogenic Acid results in increased expression of FSHR protein

NCBI chr17:89,292,380...89,508,103
Ensembl chr17:89,292,380...89,508,103

G

glucagon

multiple interactions

[Chlorogenic Acid co-treated with Rotenone] results in increased secretion of GCG protein

NCBI chr 2:62,304,874...62,313,997
Ensembl chr 2:62,304,874...62,313,994

G

glutamate-cysteine ligase, catalytic subunit

increases expression
multiple interactions

Chlorogenic Acid results in increased expression of GCLC mRNA
Chlorogenic Acid promotes the reaction [Acetaminophen results in increased expression of GCLC mRNA]

NCBI chr 9:77,661,817...77,701,771
Ensembl chr 9:77,661,817...77,701,767

G

glutamate-cysteine ligase, modifier subunit

increases expression

Chlorogenic Acid results in increased expression of GCLM mRNA

NCBI chr 3:122,039,206...122,060,864
Ensembl chr 3:122,039,206...122,064,381

G

glucagon-like peptide 1 receptor

multiple interactions

Chlorogenic Acid inhibits the reaction [Rotenone results in decreased expression of GLP1R protein]

NCBI chr17:31,120,841...31,155,484
Ensembl chr17:31,120,791...31,159,765

G

glutamic pyruvic transaminase, soluble

multiple interactions
decreases expression

Chlorogenic Acid inhibits the reaction [aluminum chloride results in increased activity of GPT protein]
Chlorogenic Acid results in decreased expression of GPT protein
Chlorogenic Acid inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased activity of GPT protein]; Chlorogenic Acid inhibits the reaction [Methotrexate results in increased activity of GPT protein]

PMID:28479099 PMID:28623112 PMID:31390532 PMID:33058431

NCBI chr15:76,580,926...76,583,875
Ensembl chr15:76,579,916...76,583,886

G

glutathione peroxidase 1

multiple interactions

Chlorogenic Acid inhibits the reaction [sodium arsenite results in decreased expression of GPX1 mRNA]

NCBI chr 9:108,216,279...108,217,541
Ensembl chr 9:108,216,102...108,217,542

G

granulin

increases expression

Chlorogenic Acid results in increased expression of GRN mRNA

NCBI chr11:102,321,333...102,327,635
Ensembl chr11:102,321,141...102,327,874

G

glycogen synthase kinase 3 beta

multiple interactions

Chlorogenic Acid inhibits the reaction [Rotenone results in decreased phosphorylation of GSK3B protein]

NCBI chr16:37,909,363...38,066,446
Ensembl chr16:37,909,363...38,066,446

G

glutathione reductase

multiple interactions

Chlorogenic Acid inhibits the reaction [Methotrexate results in decreased activity of GSR protein]
Chlorogenic Acid inhibits the reaction [sodium arsenite results in decreased activity of GSR protein]; Chlorogenic Acid inhibits the reaction [sodium arsenite results in decreased expression of GSR mRNA]

PMID:28479099 PMID:33242462

NCBI chr 8:34,143,266...34,188,190
Ensembl chr 8:34,142,551...34,188,191

G

glutathione S-transferase, alpha 1 (Ya)

increases activity

Chlorogenic Acid results in increased activity of GSTA1 protein

NCBI chr 9:78,137,951...78,149,965
Ensembl chr 9:78,137,938...78,149,966

G

hyaluronan synthase 1

increases expression

Chlorogenic Acid results in increased expression of HAS1 mRNA

NCBI chr17:18,063,588...18,075,450
Ensembl chr17:18,063,585...18,075,467

G

holocarboxylase synthetase (biotin- [propriony-Coenzyme A-carboxylase (ATP-hydrolysing)] ligase)

decreases activity

Chlorogenic Acid results in decreased activity of HLCS protein

NCBI chr16:93,930,054...94,116,098
Ensembl chr16:93,929,741...94,114,430

G

3-hydroxy-3-methylglutaryl-Coenzyme A reductase

multiple interactions
decreases expression

[tetrahydrocurcumin co-treated with Chlorogenic Acid] results in decreased susceptibility to [[Streptozocin co-treated with Niacinamide] results in increased activity of HMGCR protein]; Chlorogenic Acid results in decreased susceptibility to [[Streptozocin co-treated with Niacinamide] results in increased activity of HMGCR protein]
Chlorogenic Acid results in decreased expression of HMGCR mRNA

PMID:20696151 PMID:21870829

NCBI chr13:96,785,470...96,807,444
Ensembl chr13:96,785,475...96,807,444

G

heme oxygenase 1

multiple interactions
increases expression

Chlorogenic Acid inhibits the reaction [Cisplatin results in increased expression of HMOX1 protein]
Chlorogenic Acid inhibits the reaction [Acetaminophen results in decreased expression of HMOX1 mRNA]; Chlorogenic Acid inhibits the reaction [Acetaminophen results in decreased expression of HMOX1 protein]
Chlorogenic Acid results in increased expression of HMOX1 mRNA

PMID:25043994 PMID:29136249

NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217

G

heat shock protein 5

multiple interactions

Chlorogenic Acid inhibits the reaction [[Streptozocin co-treated with Dietary Fats co-treated with Fructose] results in increased expression of HSPA5 protein]; Chlorogenic Acid inhibits the reaction [Glucose results in increased expression of HSPA5 protein]

NCBI chr 2:34,662,102...34,666,541
Ensembl chr 2:34,661,982...34,667,559

G

heat shock protein 1

increases expression

Chlorogenic Acid results in increased expression of HSPB1 mRNA

NCBI chr 5:135,916,773...135,918,417
Ensembl chr 5:135,916,773...135,918,417

G

interleukin 1 alpha

decreases expression

Chlorogenic Acid results in decreased expression of IL1A mRNA

NCBI chr 2:129,141,530...129,151,892
Ensembl chr 2:129,141,530...129,151,892

G

interleukin 1 beta

multiple interactions

[geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased secretion of IL1B protein]; Chlorogenic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of IL1B mRNA]
Chlorogenic Acid inhibits the reaction [Acetaminophen results in increased expression of IL1B mRNA]; Chlorogenic Acid inhibits the reaction [Acetaminophen results in increased secretion of IL1B protein]; Chlorogenic Acid inhibits the reaction [sodium arsenite results in increased expression of IL1B protein]

PMID:23146752 PMID:24709313 PMID:26079055 PMID:33242462

NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059

G

interleukin 6

increases expression
multiple interactions

Chlorogenic Acid results in increased expression of IL6 mRNA
Chlorogenic Acid inhibits the reaction [Acetaminophen results in increased expression of IL6 mRNA]; Chlorogenic Acid inhibits the reaction [Acetaminophen results in increased secretion of IL6 protein]; Chlorogenic Acid inhibits the reaction [sodium arsenite results in increased expression of IL6 protein]
Chlorogenic Acid inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of IL6 protein]; Chlorogenic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of IL6 mRNA]

PMID:21870829 PMID:23146752 PMID:26079055 PMID:31390532 PMID:33242462

NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979

G

integrin beta 2

decreases expression
multiple interactions

Chlorogenic Acid results in decreased expression of ITGB2 protein
Chlorogenic Acid inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of ITGB2 protein]

NCBI chr10:77,366,164...77,401,542
Ensembl chr10:77,366,086...77,401,542

G

jun proto-oncogene

multiple interactions

Chlorogenic Acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of JUN protein]

NCBI chr 4:94,937,273...94,940,459
Ensembl chr 4:94,937,271...94,940,459

G

keratin 5

increases expression

Chlorogenic Acid results in increased expression of KRT5 mRNA

NCBI chr15:101,615,504...101,621,340
Ensembl chr15:101,615,505...101,621,333

G

lecithin cholesterol acyltransferase

multiple interactions

[tetrahydrocurcumin co-treated with Chlorogenic Acid] results in decreased susceptibility to [[Streptozocin co-treated with Niacinamide] results in decreased activity of LCAT protein]; Chlorogenic Acid results in decreased susceptibility to [[Streptozocin co-treated with Niacinamide] results in decreased activity of LCAT protein]

NCBI chr 8:106,666,183...106,670,034
Ensembl chr 8:106,666,183...106,670,014

G

luteinizing hormone beta

multiple interactions

Chlorogenic Acid inhibits the reaction [sodium arsenite results in decreased expression of LHB protein]

NCBI chr 7:45,070,370...45,071,278
Ensembl chr 7:45,070,244...45,071,321

G

lipoprotein lipase

multiple interactions

[tetrahydrocurcumin co-treated with Chlorogenic Acid] results in decreased susceptibility to [[Streptozocin co-treated with Niacinamide] results in decreased activity of LPL protein]; Chlorogenic Acid results in decreased susceptibility to [[Streptozocin co-treated with Niacinamide] results in decreased activity of LPL protein]

NCBI chr 8:69,333,207...69,359,584
Ensembl chr 8:69,333,143...69,360,100

G

monoamine oxidase A

decreases activity

Chlorogenic Acid results in decreased activity of MAOA protein

NCBI chr X:16,485,937...16,554,051
Ensembl chr X:16,485,937...16,554,057

G

monoamine oxidase B

decreases activity

Chlorogenic Acid results in decreased activity of MAOB protein

NCBI chr X:16,575,520...16,683,605
Ensembl chr X:16,575,521...16,683,605

G

mitogen-activated protein kinase kinase 4

multiple interactions

Chlorogenic Acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAP2K4 protein]

NCBI chr11:65,579,070...65,679,185
Ensembl chr11:65,579,069...65,679,123

G

mitogen-activated protein kinase 1

multiple interactions

Chlorogenic Acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK1 protein]
Chlorogenic Acid promotes the reaction [Acetaminophen results in increased phosphorylation of MAPK1 protein]

PMID:15944151 PMID:29136249

NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317

G

mitogen-activated protein kinase 14

multiple interactions

Chlorogenic Acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK14 protein]

NCBI chr17:28,910,316...28,967,379
Ensembl chr17:28,910,303...28,967,380

G

mitogen-activated protein kinase 3

multiple interactions

Chlorogenic Acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK3 protein]
Chlorogenic Acid promotes the reaction [Acetaminophen results in increased phosphorylation of MAPK3 protein]

PMID:15944151 PMID:29136249

NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991

G

mitogen-activated protein kinase 8

multiple interactions

Chlorogenic Acid inhibits the reaction [Glucose results in increased phosphorylation of MAPK8 protein]

NCBI chr14:33,099,855...33,169,213
Ensembl chr14:33,099,855...33,169,115

G

melanocortin 1 receptor

increases expression

Chlorogenic Acid results in increased expression of MC1R mRNA

NCBI chr 8:124,133,839...124,137,483
Ensembl chr 8:124,133,846...124,137,483

G

microsomal glutathione S-transferase 1

decreases activity

Chlorogenic Acid results in decreased activity of MGST1 protein

NCBI chr 6:138,117,525...138,133,753
Ensembl chr 6:138,117,314...138,133,753

G

myeloperoxidase

multiple interactions

Chlorogenic Acid inhibits the reaction [Acetaminophen results in increased expression of MPO protein]

NCBI chr11:87,684,610...87,695,238
Ensembl chr11:87,684,407...87,695,239

G

cytochrome c oxidase I, mitochondrial

increases expression

Chlorogenic Acid results in increased expression of COX1 mRNA

NCBI chr MT:5,328...6,872
Ensembl chr MT:5,328...6,872

G

cytochrome c oxidase II, mitochondrial

multiple interactions

[Chlorogenic Acid co-treated with Zymosan] results in decreased expression of COX2 protein; Chlorogenic Acid inhibits the reaction [Zymosan results in increased expression of COX2 protein]

NCBI chr MT:7,013...7,696
Ensembl chr MT:7,013...7,696

G

myeloid differentiation primary response gene 88

multiple interactions

Chlorogenic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of MYD88 mRNA]; Chlorogenic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of MYD88 protein]
Chlorogenic Acid inhibits the reaction [Acetaminophen results in increased expression of MYD88 protein]

PMID:23146752 PMID:26079055

NCBI chr 9:119,165,000...119,169,084
Ensembl chr 9:119,165,000...119,170,477

G

nuclear factor, erythroid derived 2, like 2

increases localization
decreases response to substance
multiple interactions
increases response to substance
affects localization

Chlorogenic Acid results in increased localization of NFE2L2 protein
NFE2L2 gene mutant form results in decreased susceptibility to Chlorogenic Acid
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[Chlorogenic Acid co-treated with Acetaminophen] results in increased phosphorylation of and affects the localization of and results in increased activity of NFE2L2 protein]; [Chlorogenic Acid co-treated with Acetaminophen] results in increased activity of and affects the localization of NFE2L2 protein; [Chlorogenic Acid co-treated with Acetaminophen] results in increased phosphorylation of and affects the localization of and results in increased activity of NFE2L2 protein; U 0126 inhibits the reaction [[Chlorogenic Acid co-treated with Acetaminophen] results in increased phosphorylation of and affects the localization of and results in increased activity of NFE2L2 protein]
[Chlorogenic Acid co-treated with Acetaminophen] affects the localization of and results in increased activity of NFE2L2 protein; Chlorogenic Acid inhibits the reaction [sodium arsenite results in decreased expression of NFE2L2 mRNA]
NFE2L2 results in increased susceptibility to Chlorogenic Acid
Chlorogenic Acid affects the localization of NFE2L2 protein

PMID:15944151 PMID:29136249 PMID:33242462

NCBI chr 2:75,505,860...75,535,007
Ensembl chr 2:75,505,857...75,534,985

G

nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha

multiple interactions

Chlorogenic Acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased degradation of NFKBIA protein]
Chlorogenic Acid inhibits the reaction [Carbon Tetrachloride results in decreased expression of and results in increased phosphorylation of NFKBIA protein]

PMID:20026373 PMID:23146752

NCBI chr12:55,536,194...55,539,432
Ensembl chr12:55,536,195...55,539,432

G

nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, beta

multiple interactions

Chlorogenic Acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of and results in increased activity of NFKBIB protein]

NCBI chr 7:28,457,676...28,466,069
Ensembl chr 7:28,457,676...28,466,937

G

nitric oxide synthase 2, inducible

multiple interactions

Chlorogenic Acid inhibits the reaction [[Tetradecanoylphorbol Acetate results in increased expression of NOS2 protein] which results in increased abundance of Nitrites]; Chlorogenic Acid inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; Chlorogenic Acid inhibits the reaction [sodium arsenite results in increased expression of NOS2 mRNA]; Chlorogenic Acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of NOS2 protein]
Chlorogenic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of NOS2 mRNA]; Chlorogenic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of NOS2 protein]; Chlorogenic Acid inhibits the reaction [Methotrexate results in increased expression of NOS2 protein]

PMID:20026373 PMID:23146752 PMID:28479099 PMID:31306686 PMID:33242462

NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080

G

nitric oxide synthase 3, endothelial cell

increases expression

Chlorogenic Acid results in increased expression of NOS3 mRNA

NCBI chr 5:24,569,772...24,589,472
Ensembl chr 5:24,569,808...24,589,472

G

natriuretic peptide type B

multiple interactions

Chlorogenic Acid inhibits the reaction [[Streptozocin co-treated with Dietary Fats co-treated with Fructose] results in increased expression of NPPB protein]

NCBI chr 4:148,070,264...148,071,662
Ensembl chr 4:148,070,245...148,071,662

G

NAD(P)H dehydrogenase, quinone 1

increases activity
increases expression
multiple interactions

Chlorogenic Acid results in increased activity of NQO1 protein
Chlorogenic Acid results in increased expression of NQO1 mRNA
Chlorogenic Acid inhibits the reaction [Acetaminophen results in decreased expression of NQO1 mRNA]; Chlorogenic Acid inhibits the reaction [Acetaminophen results in decreased expression of NQO1 protein]

PMID:15944151 PMID:29136249

NCBI chr 8:108,114,856...108,139,012
Ensembl chr 8:108,114,857...108,129,838

G

nuclear receptor subfamily 1, group H, member 4

increases expression
increases activity

Chlorogenic Acid results in increased expression of NR1H4 mRNA
Chlorogenic Acid results in increased activity of NR1H4 protein

NCBI chr10:89,290,096...89,369,484
Ensembl chr10:89,290,096...89,369,447

G

occludin

multiple interactions

Chlorogenic Acid inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of OCLN mRNA]; Chlorogenic Acid inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of OCLN protein]

NCBI chr13:100,633,012...100,689,226
Ensembl chr13:100,633,015...100,689,226

G

prolyl 4-hydroxylase, beta polypeptide

multiple interactions

Chlorogenic Acid inhibits the reaction [Glucose results in increased expression of P4HB protein]

NCBI chr11:120,451,124...120,464,079
Ensembl chr11:120,451,124...120,464,079

G

proliferating cell nuclear antigen

multiple interactions

Chlorogenic Acid promotes the reaction [Cisplatin results in increased expression of PCNA protein]

NCBI chr 2:132,091,206...132,095,100
Ensembl chr 2:132,091,082...132,095,234

G

platelet/endothelial cell adhesion molecule 1

multiple interactions

Chlorogenic Acid inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of PECAM1 protein]

NCBI chr11:106,545,039...106,606,107
Ensembl chr11:106,545,043...106,641,454

G

progesterone receptor

increases expression
decreases expression

Chlorogenic Acid results in increased expression of PGR mRNA
Chlorogenic Acid results in decreased expression of PGR mRNA

NCBI chr 9:8,890,017...8,968,612
Ensembl chr 9:8,899,834...8,968,612

G

phosphoinositide-3-kinase regulatory subunit 1

increases expression
multiple interactions

Chlorogenic Acid results in increased expression of PIK3R1 mRNA
Chlorogenic Acid inhibits the reaction [Rotenone results in decreased phosphorylation of PIK3R1 protein]

PMID:21870829 PMID:36048341

NCBI chr13:101,817,269...101,904,725
Ensembl chr13:101,817,071...101,904,725

G

procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3

increases expression

Chlorogenic Acid results in increased expression of PLOD3 mRNA

NCBI chr 5:137,015,873...137,025,500
Ensembl chr 5:137,015,873...137,025,502

G

peroxisome proliferator activated receptor gamma

increases expression
decreases expression

Chlorogenic Acid results in increased expression of PPARG mRNA
Chlorogenic Acid results in decreased expression of PPARG mRNA

PMID:20706672 PMID:21870829

NCBI chr 6:115,337,828...115,467,365
Ensembl chr 6:115,337,912...115,467,360

G

protein phosphatase 2, regulatory subunit A, alpha

multiple interactions

[Chlorogenic Acid co-treated with Acetaminophen] results in decreased expression of PPP2R1A protein

NCBI chr17:21,165,716...21,186,167
Ensembl chr17:21,165,573...21,186,178

G

protein phosphatase 5, catalytic subunit

multiple interactions

[Chlorogenic Acid co-treated with Acetaminophen] results in decreased expression of PPP5C protein

NCBI chr 7:16,738,575...16,761,812
Ensembl chr 7:16,738,565...16,761,849

G

prostaglandin-endoperoxide synthase 2

multiple interactions

Chlorogenic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of PTGS2 mRNA]; Chlorogenic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of PTGS2 protein]; Chlorogenic Acid inhibits the reaction [Methotrexate results in increased expression of PTGS2 protein]
Chlorogenic Acid inhibits the reaction [Cisplatin results in increased expression of PTGS2 protein]; Chlorogenic Acid inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]; Chlorogenic Acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of and results in increased expression of PTGS2 protein]

PMID:20026373 PMID:23146752 PMID:25043994 PMID:28479099 PMID:31306686

NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978

G

RAD23 homolog A, nucleotide excision repair protein

decreases expression

Chlorogenic Acid results in decreased expression of RAD23A mRNA

NCBI chr 8:85,561,540...85,567,361
Ensembl chr 8:85,560,648...85,567,294

G

retinoic acid receptor, alpha

increases expression

Chlorogenic Acid results in increased expression of RARA mRNA

NCBI chr11:98,818,626...98,865,768
Ensembl chr11:98,818,644...98,865,768

G

v-rel reticuloendotheliosis viral oncogene homolog A (avian)

multiple interactions

Chlorogenic Acid inhibits the reaction [Acetaminophen results in increased expression of and results in increased phosphorylation of and affects the localization of RELA protein]; Chlorogenic Acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of RELA protein]

PMID:20026373 PMID:26079055

NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158

G

reticulophagy regulator 1

multiple interactions

Chlorogenic Acid inhibits the reaction [Glucose results in decreased expression of RETREG1 protein]

NCBI chr15:25,840,795...25,973,782
Ensembl chr15:25,843,266...25,973,773

G

reticulon 3

multiple interactions

Chlorogenic Acid inhibits the reaction [Glucose results in increased expression of RTN3 protein]

NCBI chr19:7,403,260...7,460,656
Ensembl chr19:7,403,266...7,460,646

G

retinoid X receptor alpha

decreases expression

Chlorogenic Acid results in decreased expression of RXRA mRNA

NCBI chr 2:27,566,457...27,653,331
Ensembl chr 2:27,566,452...27,652,969

G

SEC62 homolog, preprotein translocation

multiple interactions

Chlorogenic Acid inhibits the reaction [Glucose results in increased expression of SEC62 protein]

NCBI chr 3:30,847,025...30,875,412
Ensembl chr 3:30,847,024...30,875,412

G

selectin, lymphocyte

multiple interactions

[Chlorogenic Acid co-treated with lipopolysaccharide, E. coli O26-B6] results in increased expression of SELL protein; Chlorogenic Acid inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in decreased expression of SELL protein]

NCBI chr 1:163,889,556...163,908,354
Ensembl chr 1:163,889,551...163,911,750

G

solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2

multiple interactions

Chlorogenic Acid inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of SLC11A2 mRNA]; Chlorogenic Acid inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of SLC11A2 protein]

NCBI chr15:100,285,779...100,322,090
Ensembl chr15:100,285,779...100,322,953

G

solute carrier family 22 (organic cation transporter), member 2

multiple interactions

Chlorogenic Acid inhibits the reaction [Cisplatin results in decreased expression of SLC22A2 protein]

NCBI chr17:12,803,076...12,847,376
Ensembl chr17:12,803,019...12,847,375

G

solute carrier family 2 (facilitated glucose transporter), member 4

increases expression

Chlorogenic Acid results in increased expression of SLC2A4 mRNA

NCBI chr11:69,833,112...69,839,040
Ensembl chr11:69,833,365...69,839,014

G

synuclein, alpha

multiple interactions

Chlorogenic Acid inhibits the reaction [Rotenone results in increased expression of SNCA protein]; Chlorogenic Acid inhibits the reaction [Rotenone results in increased phosphorylation of SNCA protein]

NCBI chr 6:60,708,557...60,806,839
Ensembl chr 6:60,708,559...60,806,839

G

superoxide dismutase 2, mitochondrial

multiple interactions
increases expression

Chlorogenic Acid inhibits the reaction [sodium arsenite results in decreased expression of SOD2 mRNA]
Chlorogenic Acid results in increased expression of SOD2 mRNA

NCBI chr17:13,226,726...13,237,006
Ensembl chr17:13,225,733...13,258,950

G

superoxide dismutase 3, extracellular

decreases expression

Chlorogenic Acid results in decreased expression of SOD3 mRNA

NCBI chr 5:52,521,146...52,527,080
Ensembl chr 5:52,521,133...52,528,760

G

sequestosome 1

multiple interactions

Chlorogenic Acid inhibits the reaction [Acetaminophen results in decreased expression of SQSTM1 protein]

NCBI chr11:50,090,979...50,105,303
Ensembl chr11:50,090,193...50,101,654

G

steroid 5 alpha-reductase 2

decreases expression

Chlorogenic Acid results in decreased expression of SRD5A2 mRNA

NCBI chr17:74,321,886...74,354,855
Ensembl chr17:74,323,950...74,354,911

G

steroidogenic acute regulatory protein

increases expression

Chlorogenic Acid results in increased expression of STAR protein

NCBI chr 8:26,298,502...26,306,010
Ensembl chr 8:26,296,583...26,306,010

G

tight junction protein 1

multiple interactions

Chlorogenic Acid inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of TJP1 mRNA]; Chlorogenic Acid inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of TJP1 protein]

NCBI chr 7:64,945,913...65,177,629
Ensembl chr 7:64,945,913...65,177,529

G

toll-like receptor 3

multiple interactions

Chlorogenic Acid inhibits the reaction [Acetaminophen results in increased expression of TLR3 protein]

NCBI chr 8:45,848,702...45,864,112
Ensembl chr 8:45,848,702...45,864,117

G

toll-like receptor 4

multiple interactions

Chlorogenic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of TLR4 mRNA]; Chlorogenic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of TLR4 protein]
Chlorogenic Acid inhibits the reaction [Acetaminophen results in increased expression of TLR4 protein]

PMID:23146752 PMID:26079055

NCBI chr 4:66,745,788...66,765,338
Ensembl chr 4:66,745,821...66,848,521

G

tumor necrosis factor

increases expression
multiple interactions

Chlorogenic Acid results in increased expression of TNF mRNA
Chlorogenic Acid inhibits the reaction [Acetaminophen results in increased expression of TNF mRNA]; Chlorogenic Acid inhibits the reaction [Acetaminophen results in increased secretion of TNF protein]; Chlorogenic Acid inhibits the reaction [Cisplatin results in increased expression of TNF protein]; Chlorogenic Acid inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; Chlorogenic Acid inhibits the reaction [sodium arsenite results in increased expression of TNF protein]
Chlorogenic Acid inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of TNF protein]; Chlorogenic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF mRNA]

PMID:21870829 PMID:23146752 PMID:25043994 PMID:26079055 PMID:31306686 More...

NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983

G

tumor protein, translationally-controlled 1

increases expression

Chlorogenic Acid results in increased expression of TPT1 mRNA

NCBI chr14:76,082,771...76,085,743
Ensembl chr14:76,082,533...76,085,965

G

TNF receptor-associated factor 2

multiple interactions

Chlorogenic Acid inhibits the reaction [Glucose results in increased expression of TRAF2 protein]

NCBI chr 2:25,407,994...25,436,952
Ensembl chr 2:25,407,994...25,436,952

G

transformation related protein 53

multiple interactions
increases expression

Chlorogenic Acid inhibits the reaction [Cisplatin results in increased expression of TRP53 protein]
Chlorogenic Acid results in increased expression of TRP53 mRNA

PMID:25043994 PMID:33058431

NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699

G

thioredoxin 1

increases expression

Chlorogenic Acid results in increased expression of TXN mRNA

NCBI chr 4:57,943,373...57,956,411
Ensembl chr 4:57,943,373...57,956,411

G

tyrosinase

increases oxidation
multiple interactions

TYR protein results in increased oxidation of Chlorogenic Acid
[TYR protein results in increased oxidation of Chlorogenic Acid] which results in decreased abundance of Glutathione

NCBI chr 7:87,073,979...87,142,637
Ensembl chr 7:87,073,979...87,142,720

G

tyrosinase-related protein 1

decreases expression

Chlorogenic Acid results in decreased expression of TYRP1 mRNA

NCBI chr 4:80,752,360...80,769,973
Ensembl chr 4:80,752,360...80,769,956

G

UDP glucuronosyltransferase 1 family, polypeptide A1

decreases activity

Chlorogenic Acid results in decreased activity of UGT1A1 protein

NCBI chr 1:88,139,681...88,147,724
Ensembl chr 1:88,139,681...88,146,719

G

UDP glycosyltransferase 1 family, polypeptide A10

increases glucuronidation
decreases activity

UGT1A10 protein results in increased glucuronidation of Chlorogenic Acid
Chlorogenic Acid results in decreased activity of UGT1A10 protein

PMID:15117964 PMID:35868516

NCBI chr 1:87,983,133...88,147,724
Ensembl chr 1:87,983,110...88,146,726

G

UDP glucuronosyltransferase 1 family, polypeptide A2

increases glucuronidation
decreases activity

UGT1A3 protein results in increased glucuronidation of Chlorogenic Acid
Chlorogenic Acid results in decreased activity of UGT1A3 protein

PMID:15117964 PMID:35868516

NCBI chr 1:88,128,333...88,147,724
Ensembl chr 1:88,128,323...88,146,719

G

UDP glucuronosyltransferase 1 family, polypeptide A6B

decreases activity

Chlorogenic Acid results in decreased activity of UGT1A6 protein

NCBI chr 1:88,030,979...88,146,720
Ensembl chr 1:88,030,974...88,146,725

G

UDP glucuronosyltransferase 1 family, polypeptide A9

decreases activity

Chlorogenic Acid results in decreased activity of UGT1A9 protein

NCBI chr 1:87,998,501...88,147,724
Ensembl chr 1:87,998,522...88,146,719

G

UDP glucuronosyltransferase 2 family, polypeptide B1

decreases activity

Chlorogenic Acid results in decreased activity of UGT2B17 protein

NCBI chr 5:87,064,498...87,074,362
Ensembl chr 5:87,064,497...87,074,389

G

UDP glucuronosyltransferase 2 family, polypeptide B34

decreases activity

Chlorogenic Acid results in decreased activity of UGT2B7 protein

NCBI chr 5:87,037,613...87,054,805
Ensembl chr 5:87,037,626...87,054,796

G

X-box binding protein 1

multiple interactions

Chlorogenic Acid inhibits the reaction [Glucose results in increased expression of XBP1 mRNA]

NCBI chr11:5,470,641...5,475,993
Ensembl chr11:5,470,659...5,475,893

cis-caffeic acid

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

acetyl-Coenzyme A carboxylase alpha

multiple interactions

caffeic acid results in increased phosphorylation of and results in decreased activity of ACACA protein

NCBI chr11:84,020,461...84,292,477
Ensembl chr11:84,020,498...84,292,477

G

acetylcholinesterase

multiple interactions
decreases activity

caffeic acid inhibits the reaction [Caffeine results in decreased activity of ACHE protein]; Caffeine promotes the reaction [caffeic acid results in decreased activity of ACHE protein]

NCBI chr 5:137,286,516...137,292,728
Ensembl chr 5:137,285,781...137,292,728

G

ATP citrate lyase

multiple interactions

[Metformin co-treated with caffeic acid] results in decreased expression of ACLY protein

NCBI chr11:100,367,178...100,418,826
Ensembl chr11:100,367,179...100,418,826

G

arachidonate 15-lipoxygenase

multiple interactions
decreases activity

[caffeic acid results in decreased activity of ALOX15 protein] inhibits the reaction [vorinostat results in increased activity of CASP3 protein]; [caffeic acid results in decreased activity of ALOX15 protein] which results in decreased chemical synthesis of 13-hydroxy-9,11-octadecadienoic acid; [caffeic acid results in decreased activity of ALOX15 protein] which results in increased abundance of 13-hydroxy-9,11-octadecadienoic acid; caffeic acid inhibits the reaction [N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide results in increased activity of ALOX15 protein]

PMID:10904086 PMID:11406566 PMID:15574791

NCBI chr11:70,234,973...70,279,465
Ensembl chr11:70,234,978...70,242,857

G

arachidonate 5-lipoxygenase

multiple interactions

caffeic acid inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] affects the localization of ALOX5 protein]; caffeic acid inhibits the reaction [Aluminum results in increased expression of ALOX5 mRNA]; caffeic acid inhibits the reaction [Aluminum results in increased expression of ALOX5 protein]; caffeic acid inhibits the reaction [Hydrogen Peroxide affects the localization of ALOX5 protein]
caffeic acid inhibits the reaction [aluminum chloride results in increased expression of ALOX5 mRNA]; caffeic acid inhibits the reaction [aluminum chloride results in increased expression of ALOX5 protein]

PMID:18482095 PMID:18951527 PMID:27368151

NCBI chr 6:116,387,030...116,438,139
Ensembl chr 6:116,387,038...116,438,139

G

amyloid beta precursor protein

multiple interactions

caffeic acid inhibits the reaction [aluminum chloride results in increased expression of APP protein modified form]; caffeic acid inhibits the reaction [aluminum chloride results in increased expression of APP protein]

NCBI chr16:84,751,236...84,972,187
Ensembl chr16:84,746,573...84,970,654

G

arginase, liver

decreases activity

caffeic acid results in decreased activity of ARG1 protein

NCBI chr10:24,791,105...24,803,368
Ensembl chr10:24,791,119...24,803,382

G

ATPase, H+ transporting, lysosomal V0 subunit D2

multiple interactions

caffeic acid promotes the reaction [Thapsigargin results in decreased expression of ATP6V0D2 mRNA]

NCBI chr 4:19,876,838...19,922,566
Ensembl chr 4:19,876,841...19,922,605

G

caspase 3

multiple interactions

[caffeic acid results in decreased activity of ALOX15 protein] inhibits the reaction [vorinostat results in increased activity of CASP3 protein]
caffeic acid inhibits the reaction [Valproic Acid results in increased expression of CASP3 protein]

PMID:15574791 PMID:29968957

NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724

G

catalase

multiple interactions
increases activity

caffeic acid inhibits the reaction [Cisplatin results in decreased activity of CAT protein]; caffeic acid inhibits the reaction [Nickel results in decreased activity of CAT protein]
caffeic acid results in increased activity of CAT protein
caffeic acid inhibits the reaction [Tetradecanoylphorbol Acetate inhibits the reaction [CAT protein results in increased metabolism of Hydrogen Peroxide]]; caffeic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased activity of CAT protein]

PMID:18405891 PMID:21640567 PMID:22036979 PMID:27378625

NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505

G

C-C motif chemokine ligand 2

multiple interactions

[Resveratrol co-treated with Catechin co-treated with caffeic acid] results in decreased expression of CCL2 mRNA; caffeic acid inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL2 protein]

PMID:16806235 PMID:31306686

NCBI chr11:81,926,403...81,928,278
Ensembl chr11:81,926,397...81,928,279

G

C-C motif chemokine ligand 3

multiple interactions

[resveratrol co-treated with Catechin co-treated with caffeic acid] results in decreased expression of CCL3 mRNA

NCBI chr11:83,538,669...83,540,204
Ensembl chr11:83,538,670...83,540,181

G

C-C motif chemokine ligand 4

multiple interactions

[resveratrol co-treated with Catechin co-treated with caffeic acid] results in decreased expression of CCL4 mRNA

NCBI chr11:83,553,410...83,555,509
Ensembl chr11:83,553,410...83,555,509

G

C-C motif chemokine receptor 1

multiple interactions

[resveratrol co-treated with Catechin co-treated with caffeic acid] results in decreased expression of CCR1 mRNA

NCBI chr 9:123,762,163...123,768,729
Ensembl chr 9:123,762,161...123,768,729

G

C-C motif chemokine receptor 2

multiple interactions

[resveratrol co-treated with Catechin co-treated with caffeic acid] results in decreased expression of CCR2 mRNA

NCBI chr 9:123,901,954...123,913,594
Ensembl chr 9:123,901,987...123,913,594

G

C-C motif chemokine receptor 4

multiple interactions

[resveratrol co-treated with Catechin co-treated with caffeic acid] results in decreased expression of CCR4 mRNA

NCBI chr 9:114,319,384...114,334,544
Ensembl chr 9:114,319,384...114,333,984

G

CD4 antigen

multiple interactions

[resveratrol co-treated with Catechin co-treated with caffeic acid] results in decreased expression of CD4 mRNA

NCBI chr 6:124,841,656...124,865,210
Ensembl chr 6:124,841,655...124,865,184

G

CD68 antigen

multiple interactions

[resveratrol co-treated with Catechin co-treated with caffeic acid] results in decreased expression of CD68 mRNA

NCBI chr11:69,555,039...69,556,996
Ensembl chr11:69,555,039...69,556,979

G

cell division cycle 20

multiple interactions

[Thapsigargin co-treated with caffeic acid] results in increased expression of CDC20 mRNA

NCBI chr 4:118,290,098...118,294,540
Ensembl chr 4:118,290,098...118,294,549

G

cyclin dependent kinase 2

multiple interactions

caffeic acid promotes the reaction [Thapsigargin results in increased expression of CDK2 mRNA]

NCBI chr10:128,533,807...128,540,920
Ensembl chr10:128,533,808...128,540,900

G

choline acetyltransferase

multiple interactions

caffeic acid inhibits the reaction [aluminum chloride results in decreased expression of CHAT protein]

NCBI chr14:32,130,160...32,187,866
Ensembl chr14:32,130,160...32,187,946

G

catechol-O-methyltransferase

increases methylation

COMT protein results in increased methylation of caffeic acid

NCBI chr16:18,225,632...18,247,006
Ensembl chr16:18,225,636...18,245,602

G

corticotropin releasing hormone

multiple interactions

caffeic acid inhibits the reaction [Malathion results in decreased expression of CRH mRNA]

NCBI chr 3:19,747,565...19,749,560
Ensembl chr 3:19,747,565...19,749,560

G

cardiotrophin 1

multiple interactions

caffeic acid promotes the reaction [Thapsigargin results in decreased expression of CTF1 mRNA]

NCBI chr 7:127,311,872...127,317,360
Ensembl chr 7:127,311,908...127,317,364

G

cathepsin B

multiple interactions

caffeic acid inhibits the reaction [Isoproterenol results in increased activity of CTSB protein]

NCBI chr14:63,359,911...63,383,372
Ensembl chr14:63,359,911...63,383,372

G

cathepsin D

multiple interactions

caffeic acid inhibits the reaction [Isoproterenol affects the activity of CTSD protein]

NCBI chr 7:141,929,647...141,941,564
Ensembl chr 7:141,929,648...141,941,775

G

C-X-C motif chemokine ligand 15

multiple interactions

caffeic acid inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL8 mRNA]; caffeic acid inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL8 protein]

NCBI chr 5:90,942,393...90,950,926
Ensembl chr 5:90,942,393...90,950,926

G

C-X-C motif chemokine ligand 2

multiple interactions

caffeic acid promotes the reaction [Thapsigargin results in decreased expression of CXCL2 mRNA]

NCBI chr 5:91,051,758...91,053,797
Ensembl chr 5:91,051,730...91,053,797

G

cytochrome P450, family 2, subfamily e, polypeptide 1

multiple interactions

caffeic acid inhibits the reaction [CYP2E1 protein results in increased reduction of tirapazamine]

NCBI chr 7:140,343,732...140,354,903
Ensembl chr 7:140,343,652...140,354,900

G

death-associated protein

multiple interactions

caffeic acid promotes the reaction [Thapsigargin results in decreased expression of DAP mRNA]

NCBI chr15:31,224,531...31,274,484
Ensembl chr15:31,224,460...31,274,487

G

DnaJ heat shock protein family (Hsp40) member B11

multiple interactions

caffeic acid promotes the reaction [Thapsigargin results in decreased expression of DNAJB11 mRNA]

NCBI chr16:22,676,595...22,698,384
Ensembl chr16:22,676,595...22,698,384

G

dihydropyrimidinase-like 4

multiple interactions

caffeic acid promotes the reaction [Thapsigargin results in increased expression of DPYSL4 mRNA]

NCBI chr 7:138,665,917...138,681,711
Ensembl chr 7:138,665,917...138,682,620

G

endothelin 1

multiple interactions

[resveratrol co-treated with Catechin co-treated with caffeic acid] results in decreased expression of EDN1 mRNA

NCBI chr13:42,454,952...42,461,466
Ensembl chr13:42,454,952...42,461,466

G

early growth response 1

multiple interactions

caffeic acid affects the reaction [Acetaminophen results in increased expression of and affects the localization of EGR1 protein]; caffeic acid inhibits the reaction [Acetaminophen results in increased expression of EGR1 mRNA]

NCBI chr18:34,994,260...34,998,009
Ensembl chr18:34,992,876...34,998,037

G

engulfment and cell motility 2

multiple interactions

caffeic acid promotes the reaction [Thapsigargin results in decreased expression of ELMO2 mRNA]

NCBI chr 2:165,129,951...165,168,421
Ensembl chr 2:165,129,951...165,168,399

G

Ets2 repressor factor

multiple interactions

caffeic acid promotes the reaction [Thapsigargin results in increased expression of ERF mRNA]

NCBI chr 7:24,941,985...24,950,522
Ensembl chr 7:24,941,986...24,950,186

G

coagulation factor III

multiple interactions

caffeic acid inhibits the reaction [Acetaminophen results in increased expression of F3 protein]

NCBI chr 3:121,517,186...121,528,701
Ensembl chr 3:121,517,186...121,528,697

G

fatty acid synthase

decreases expression
multiple interactions

caffeic acid results in decreased expression of FASN mRNA
[Metformin co-treated with caffeic acid] results in decreased expression of FASN protein

PMID:21870829 PMID:28576465

NCBI chr11:120,696,784...120,715,992
Ensembl chr11:120,696,672...120,715,373

G

fibronectin leucine rich transmembrane protein 2

multiple interactions

caffeic acid promotes the reaction [Thapsigargin results in decreased expression of FLRT2 mRNA]

NCBI chr12:95,658,780...95,751,989
Ensembl chr12:95,659,000...95,751,989

G

FMS-like tyrosine kinase 4

multiple interactions

caffeic acid promotes the reaction [Thapsigargin results in decreased expression of FLT4 mRNA]

NCBI chr11:49,500,506...49,543,566
Ensembl chr11:49,500,090...49,543,566

G

glucose-6-phosphate dehydrogenase X-linked

decreases activity

caffeic acid results in decreased activity of G6PD protein

NCBI chr X:73,453,089...73,472,486
Ensembl chr X:73,453,089...73,472,800

G

growth arrest and DNA-damage-inducible 45 alpha

multiple interactions

caffeic acid inhibits the reaction [Acetaminophen results in increased expression of GADD45A mRNA]; caffeic acid inhibits the reaction [Acetaminophen results in increased expression of GADD45A protein]

NCBI chr 6:67,012,080...67,014,391
Ensembl chr 6:67,012,080...67,014,441

G

galactosidase, beta 1

multiple interactions

caffeic acid inhibits the reaction [Isoproterenol affects the activity of GLB1 protein]

NCBI chr 9:114,230,146...114,303,447
Ensembl chr 9:114,230,144...114,303,966

G

glutaminase

increases expression

caffeic acid results in increased expression of GLS protein

NCBI chr 1:52,202,608...52,274,168
Ensembl chr 1:52,202,607...52,272,391

G

glutamic-oxaloacetic transaminase 1, soluble

multiple interactions

caffeic acid inhibits the reaction [tert-Butylhydroperoxide results in increased activity of GOT1 protein]

NCBI chr19:43,488,191...43,514,743
Ensembl chr19:43,488,191...43,513,044

G

glutamic pyruvic transaminase, soluble

multiple interactions

caffeic acid inhibits the reaction [tert-Butylhydroperoxide results in increased activity of GPT protein]
caffeic acid inhibits the reaction [Acetaminophen results in increased activity of GPT protein]

PMID:15212457 PMID:27720869

NCBI chr15:76,580,926...76,583,875
Ensembl chr15:76,579,916...76,583,886

G

glutathione reductase

multiple interactions

caffeic acid inhibits the reaction [Cisplatin results in decreased activity of GSR protein]
caffeic acid inhibits the reaction [Tetradecanoylphorbol Acetate inhibits the reaction [GSR protein results in increased oxidation of NADP]]; caffeic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased activity of GSR protein]
caffeic acid promotes the reaction [Thapsigargin results in decreased expression of GSR mRNA]

PMID:19442820 PMID:21640567 PMID:22036979

NCBI chr 8:34,143,266...34,188,190
Ensembl chr 8:34,142,551...34,188,191

G

glutathione S-transferase, mu 1

decreases activity

caffeic acid results in decreased activity of GSTM1 protein

NCBI chr 3:107,919,566...107,925,289
Ensembl chr 3:107,919,571...107,925,289

G

glutathione S-transferase, mu 2

decreases activity

caffeic acid results in decreased activity of GSTM2 protein

NCBI chr 3:107,889,018...107,893,736
Ensembl chr 3:107,889,018...107,893,769

G

glutathione S-transferase, pi 1

decreases activity

caffeic acid results in decreased activity of GSTP1 protein

NCBI chr19:4,085,411...4,087,912
Ensembl chr19:4,085,407...4,087,985

G

glucuronidase, beta

multiple interactions

caffeic acid inhibits the reaction [Isoproterenol results in increased activity of GUSB protein]

NCBI chr 5:130,011,278...130,031,890
Ensembl chr 5:130,017,852...130,031,890

G

hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)

multiple interactions

caffeic acid inhibits the reaction [Cisplatin results in decreased activity of H6PD protein]

NCBI chr 4:150,063,931...150,093,480
Ensembl chr 4:150,063,932...150,093,480

G

hepatitis A virus cellular receptor 2

multiple interactions

[resveratrol co-treated with Catechin co-treated with caffeic acid] results in decreased expression of HAVCR2 mRNA

NCBI chr11:46,345,758...46,372,082
Ensembl chr11:46,345,762...46,372,082

G

hes family bHLH transcription factor 1

multiple interactions

caffeic acid inhibits the reaction [Valproic Acid results in increased expression of HES1 mRNA]

NCBI chr16:29,883,259...29,886,614
Ensembl chr16:29,883,202...29,886,614

G

holocarboxylase synthetase (biotin- [propriony-Coenzyme A-carboxylase (ATP-hydrolysing)] ligase)

decreases activity

caffeic acid results in decreased activity of HLCS protein

NCBI chr16:93,930,054...94,116,098
Ensembl chr16:93,929,741...94,114,430

G

3-hydroxy-3-methylglutaryl-Coenzyme A reductase

decreases expression

caffeic acid results in decreased expression of HMGCR mRNA

NCBI chr13:96,785,470...96,807,444
Ensembl chr13:96,785,475...96,807,444

G

heat shock protein 90, beta (Grp94), member 1

multiple interactions

caffeic acid promotes the reaction [Thapsigargin results in decreased expression of HSP90B1 mRNA]

NCBI chr10:86,526,705...86,541,308
Ensembl chr10:86,526,073...86,541,373

G

heat shock protein 1 (chaperonin 10)

multiple interactions

caffeic acid promotes the reaction [Thapsigargin results in increased expression of HSPE1 mRNA]

NCBI chr 1:55,127,307...55,130,476
Ensembl chr 1:55,127,291...55,130,466

G

interferon gamma

increases expression
multiple interactions

caffeic acid results in increased expression of IFNG protein
caffeic acid inhibits the reaction [Valproic Acid results in increased expression of IFNG protein]

PMID:27378625 PMID:29968957

NCBI chr10:118,276,951...118,281,799
Ensembl chr10:118,276,951...118,281,797

G

interleukin 10

decreases expression

caffeic acid results in decreased expression of IL10 protein

NCBI chr 1:130,947,459...130,952,707
Ensembl chr 1:130,947,582...130,952,711

G

interleukin 1 beta

multiple interactions

caffeic acid inhibits the reaction [Acetaminophen results in increased expression of IL1B protein]
caffeic acid inhibits the reaction [Aluminum results in increased expression of IL1B protein]

PMID:27368151 PMID:27720869

NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059

G

interleukin 2

increases expression

caffeic acid results in increased expression of IL2 protein

NCBI chr 3:37,174,862...37,180,103
Ensembl chr 3:37,174,672...37,180,108

G

interleukin 21 receptor

multiple interactions

caffeic acid promotes the reaction [Thapsigargin results in decreased expression of IL21R mRNA]

NCBI chr 7:125,202,424...125,232,742
Ensembl chr 7:125,202,601...125,232,742

G

interleukin 4

decreases expression

caffeic acid results in decreased expression of IL4 protein

NCBI chr11:53,503,287...53,509,492
Ensembl chr11:53,493,809...53,509,496

G

interleukin 6

increases expression
multiple interactions

caffeic acid results in increased expression of IL6 mRNA
caffeic acid inhibits the reaction [Acetaminophen results in increased expression of IL6 protein]
caffeic acid inhibits the reaction [Aluminum results in increased expression of IL6 protein]

PMID:21870829 PMID:27368151 PMID:27720869

NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979

G

kinesin family member 15

multiple interactions

[Thapsigargin co-treated with caffeic acid] results in increased expression of KIF15 mRNA

NCBI chr 9:122,780,146...122,847,798
Ensembl chr 9:122,780,111...122,847,798

G

kinesin family member 20B

multiple interactions

caffeic acid promotes the reaction [Thapsigargin results in increased expression of KIF20B mRNA]

NCBI chr19:34,899,735...34,953,150
Ensembl chr19:34,899,761...34,953,145

G

kinesin family member 2C

multiple interactions

caffeic acid inhibits the reaction [Thapsigargin results in increased expression of KIF2C mRNA]

NCBI chr 4:117,016,830...117,039,821
Ensembl chr 4:117,016,836...117,039,836

G

lactate dehydrogenase A

multiple interactions

caffeic acid inhibits the reaction [Isoproterenol results in increased expression of LDHA protein]

NCBI chr 7:46,491,698...46,505,051
Ensembl chr 7:46,490,899...46,505,051

G

lactate dehydrogenase B

multiple interactions

caffeic acid inhibits the reaction [Isoproterenol results in increased expression of LDHB protein]

NCBI chr 6:142,435,975...142,453,683
Ensembl chr 6:142,435,975...142,453,683

G

monoamine oxidase A

decreases activity

caffeic acid results in decreased activity of MAOA protein

NCBI chr X:16,485,937...16,554,051
Ensembl chr X:16,485,937...16,554,057

G

monoamine oxidase B

decreases activity

caffeic acid results in decreased activity of MAOB protein

NCBI chr X:16,575,520...16,683,605
Ensembl chr X:16,575,521...16,683,605

G

mitogen-activated protein kinase kinase 5

multiple interactions

[Thapsigargin co-treated with caffeic acid] results in decreased expression of MAP2K5 mRNA

NCBI chr 9:63,071,050...63,288,964
Ensembl chr 9:63,071,050...63,285,184

G

mitogen-activated protein kinase 1

multiple interactions

caffeic acid inhibits the reaction [Acetaminophen results in increased phosphorylation of MAPK1 protein]

NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317

G

mitogen-activated protein kinase 3

multiple interactions

caffeic acid inhibits the reaction [Acetaminophen results in increased phosphorylation of MAPK3 protein]

NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991

G

mitofusin 1

multiple interactions

caffeic acid promotes the reaction [Thapsigargin results in decreased expression of MFN1 mRNA]

NCBI chr 3:32,583,594...32,633,384
Ensembl chr 3:32,583,614...32,633,388

G

microsomal glutathione S-transferase 1

increases activity

caffeic acid results in increased activity of MGST1 protein

NCBI chr 6:138,117,525...138,133,753
Ensembl chr 6:138,117,314...138,133,753

G

myeloperoxidase

multiple interactions
decreases activity

caffeic acid inhibits the reaction [Tetradecanoylphorbol Acetate promotes the reaction [MPO protein results in increased metabolism of Hydrogen Peroxide]]; caffeic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of MPO protein]
caffeic acid inhibits the reaction [Ethanol results in increased activity of MPO protein]; NG-Nitroarginine Methyl Ester inhibits the reaction [caffeic acid inhibits the reaction [Ethanol results in increased activity of MPO protein]]
caffeic acid results in decreased activity of MPO protein

PMID:22036979 PMID:24060682 PMID:33301711

NCBI chr11:87,684,610...87,695,238
Ensembl chr11:87,684,407...87,695,239

G

mitochondrial ribosomal protein L45

multiple interactions

caffeic acid promotes the reaction [Thapsigargin results in decreased expression of MRPL45 mRNA]

NCBI chr11:97,205,749...97,220,746
Ensembl chr11:97,206,542...97,220,746

G

mitochondrial ribosome recycling factor

multiple interactions

caffeic acid promotes the reaction [Thapsigargin results in decreased expression of MRRF mRNA]

NCBI chr 2:36,025,672...36,080,296
Ensembl chr 2:36,026,401...36,080,659

G

cytochrome c oxidase II, mitochondrial

multiple interactions

[caffeic acid co-treated with Zymosan] results in increased expression of COX2 protein; caffeic acid inhibits the reaction [Zymosan results in increased expression of COX2 protein]

NCBI chr MT:7,013...7,696
Ensembl chr MT:7,013...7,696

G

Norrie disease (pseudoglioma) (human)

increases expression

caffeic acid results in increased expression of NDP mRNA

NCBI chr X:16,751,760...16,778,013
Ensembl chr X:16,751,760...16,778,013

G

nitric oxide synthase 2, inducible

multiple interactions

caffeic acid inhibits the reaction [Valproic Acid results in increased expression of NOS2 protein]
caffeic acid inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]

PMID:29968957 PMID:31306686

NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080

G

nitric oxide synthase 3, endothelial cell

increases expression

caffeic acid results in increased expression of NOS3 mRNA

NCBI chr 5:24,569,772...24,589,472
Ensembl chr 5:24,569,808...24,589,472

G

notch 1

multiple interactions

caffeic acid inhibits the reaction [Valproic Acid results in increased expression of NOTCH1 mRNA]

NCBI chr 2:26,347,914...26,393,834
Ensembl chr 2:26,347,915...26,406,675

G

5' nucleotidase, ecto

decreases activity
multiple interactions

caffeic acid results in decreased activity of NT5E protein
caffeic acid inhibits the reaction [Caffeine results in decreased activity of NT5E protein]; Caffeine promotes the reaction [caffeic acid results in decreased activity of NT5E protein]

NCBI chr 9:88,209,662...88,254,142
Ensembl chr 9:88,209,250...88,254,145

G

programmed cell death 10

multiple interactions

caffeic acid promotes the reaction [Thapsigargin results in decreased expression of PDCD10 mRNA]

NCBI chr 3:75,423,797...75,464,159
Ensembl chr 3:75,423,797...75,464,163

G

phosphogluconate dehydrogenase

decreases activity

caffeic acid results in decreased activity of PGD protein

NCBI chr 4:149,234,448...149,251,162
Ensembl chr 4:149,234,448...149,251,228

G

phosphoinositide-3-kinase regulatory subunit 1

increases expression

caffeic acid results in increased expression of PIK3R1 mRNA

NCBI chr13:101,817,269...101,904,725
Ensembl chr13:101,817,071...101,904,725

G

polo like kinase 1

multiple interactions

[Thapsigargin co-treated with caffeic acid] results in increased expression of PLK1 mRNA

NCBI chr 7:121,758,658...121,769,107
Ensembl chr 7:121,758,662...121,769,096

G

polo like kinase 4

multiple interactions

caffeic acid promotes the reaction [Thapsigargin results in increased expression of PLK4 mRNA]

NCBI chr 3:40,754,463...40,771,318
Ensembl chr 3:40,754,454...40,771,318

G

peroxisome proliferator activated receptor gamma

increases expression

caffeic acid results in increased expression of PPARG mRNA

NCBI chr 6:115,337,828...115,467,365
Ensembl chr 6:115,337,912...115,467,360

G

peroxiredoxin 5

multiple interactions

caffeic acid promotes the reaction [Thapsigargin results in decreased expression of PRDX5 mRNA]

NCBI chr19:6,884,065...6,887,474
Ensembl chr19:6,884,065...6,887,474

G

prostaglandin-endoperoxide synthase 2

multiple interactions

caffeic acid inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]; caffeic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 protein]
caffeic acid promotes the reaction [Thapsigargin results in decreased expression of PTGS2 mRNA]

PMID:19442820 PMID:22036979 PMID:31306686

NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978

G

pentraxin related gene

multiple interactions

caffeic acid promotes the reaction [Thapsigargin results in decreased expression of PTX3 mRNA]

NCBI chr 3:66,127,308...66,133,227
Ensembl chr 3:66,127,331...66,133,226

G

v-raf-leukemia viral oncogene 1

multiple interactions

caffeic acid inhibits the reaction [Acetaminophen results in increased phosphorylation of RAF1 protein]

NCBI chr 6:115,595,530...115,653,596
Ensembl chr 6:115,595,028...115,653,596

G

v-rel reticuloendotheliosis viral oncogene homolog A (avian)

multiple interactions

caffeic acid inhibits the reaction [Valproic Acid results in increased expression of RELA protein]

NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158

G

stearoyl-Coenzyme A desaturase 2

multiple interactions

[Metformin co-treated with caffeic acid] results in decreased expression of SCD1 protein

NCBI chr19:44,282,115...44,295,303
Ensembl chr19:44,282,113...44,295,303

G

serine (or cysteine) peptidase inhibitor, clade E, member 1

multiple interactions

caffeic acid inhibits the reaction [Acetaminophen results in increased expression of SERPINE1 protein]

NCBI chr 5:137,090,358...137,101,126
Ensembl chr 5:137,090,358...137,101,122

G

sideroflexin 4

multiple interactions

caffeic acid promotes the reaction [Thapsigargin results in decreased expression of SFXN4 mRNA]

NCBI chr19:60,824,747...60,850,222
Ensembl chr19:60,825,715...60,849,917

G

solute carrier family 2 (facilitated glucose transporter), member 2

increases expression

caffeic acid results in increased expression of SLC2A2 mRNA

NCBI chr 3:28,752,052...28,782,510
Ensembl chr 3:28,752,052...28,785,508

G

solute carrier family 2 (facilitated glucose transporter), member 4

increases expression

caffeic acid results in increased expression of SLC2A4 mRNA

NCBI chr11:69,833,112...69,839,040
Ensembl chr11:69,833,365...69,839,014

G

solute carrier family 5 (sodium/glucose cotransporter), member 1

increases expression

caffeic acid results in increased expression of SLC5A1 mRNA

NCBI chr 5:33,261,563...33,320,043
Ensembl chr 5:33,261,563...33,320,214

G

synuclein, alpha

multiple interactions

caffeic acid inhibits the reaction [SNCA protein binds to SNCA protein]

NCBI chr 6:60,708,557...60,806,839
Ensembl chr 6:60,708,559...60,806,839

G

sterol regulatory element binding transcription factor 1

multiple interactions

[Metformin co-treated with caffeic acid] results in decreased expression of SREBF1 protein

NCBI chr11:60,089,910...60,113,407
Ensembl chr11:60,089,915...60,113,407

G

serine/threonine kinase 32A

multiple interactions

[Thapsigargin co-treated with caffeic acid] results in decreased expression of STK32A mRNA

NCBI chr18:43,340,762...43,450,546
Ensembl chr18:43,340,648...43,451,747

G

sulfotransferase family 1A, phenol-preferring, member 1

increases sulfation

SULT1A2 protein results in increased sulfation of caffeic acid

NCBI chr 7:126,272,042...126,289,615
Ensembl chr 7:126,272,037...126,275,604

G

sulfotransferase family, cytosolic, 1C, member 2

increases sulfation

SULT1C2 protein results in increased sulfation of caffeic acid

NCBI chr17:54,136,665...54,152,986
Ensembl chr17:54,136,665...54,153,367

G

tumor necrosis factor

increases expression
multiple interactions

caffeic acid results in increased expression of TNF mRNA
caffeic acid inhibits the reaction [Aluminum results in increased expression of TNF protein]; caffeic acid inhibits the reaction [Valproic Acid results in increased expression of TNF protein]
caffeic acid inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; caffeic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of TNF protein]

PMID:21870829 PMID:22036979 PMID:27368151 PMID:29968957 PMID:31306686

NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983

G

transformation related protein 53

affects expression
multiple interactions

caffeic acid affects the expression of TP53 protein
caffeic acid promotes the reaction [Thapsigargin results in decreased expression of TP53 mRNA]

PMID:11522280 PMID:19442820

NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699

G

tyrosinase

increases oxidation
multiple interactions

TYR protein results in increased oxidation of caffeic acid
[TYR protein results in increased oxidation of caffeic acid] which results in decreased abundance of Glutathione

NCBI chr 7:87,073,979...87,142,637
Ensembl chr 7:87,073,979...87,142,720

G

ubiquitin-conjugating enzyme E2C

multiple interactions

caffeic acid promotes the reaction [Thapsigargin results in increased expression of UBE2C mRNA]

NCBI chr 2:164,611,849...164,614,822
Ensembl chr 2:164,611,818...164,620,742

G

UDP glucuronosyltransferase 1 family, polypeptide A1

decreases activity

caffeic acid results in decreased activity of UGT1A1 protein

NCBI chr 1:88,139,681...88,147,724
Ensembl chr 1:88,139,681...88,146,719

G

UDP glycosyltransferase 1 family, polypeptide A10

increases glucuronidation
decreases activity

UGT1A10 protein results in increased glucuronidation of caffeic acid
caffeic acid results in decreased activity of UGT1A10 protein

PMID:15117964 PMID:35868516

NCBI chr 1:87,983,133...88,147,724
Ensembl chr 1:87,983,110...88,146,726

G

UDP glucuronosyltransferase 1 family, polypeptide A2

increases glucuronidation
decreases activity

UGT1A3 protein results in increased glucuronidation of caffeic acid
caffeic acid results in decreased activity of UGT1A3 protein

PMID:15117964 PMID:35868516

NCBI chr 1:88,128,333...88,147,724
Ensembl chr 1:88,128,323...88,146,719

G

UDP glucuronosyltransferase 1 family, polypeptide A6B

decreases activity

caffeic acid results in decreased activity of UGT1A6 protein

NCBI chr 1:88,030,979...88,146,720
Ensembl chr 1:88,030,974...88,146,725

G

UDP glucuronosyltransferase 1 family, polypeptide A9

decreases activity

caffeic acid results in decreased activity of UGT1A9 protein

NCBI chr 1:87,998,501...88,147,724
Ensembl chr 1:87,998,522...88,146,719

G

UDP glucuronosyltransferase 2 family, polypeptide B1

decreases activity

caffeic acid results in decreased activity of UGT2B17 protein

NCBI chr 5:87,064,498...87,074,362
Ensembl chr 5:87,064,497...87,074,389

G

UDP glucuronosyltransferase 2 family, polypeptide B34

decreases activity

caffeic acid results in decreased activity of UGT2B7 protein

NCBI chr 5:87,037,613...87,054,805
Ensembl chr 5:87,037,626...87,054,796

G

vascular endothelial growth factor A

decreases secretion

caffeic acid results in decreased secretion of VEGFA protein

NCBI chr17:46,327,919...46,343,303
Ensembl chr17:46,327,919...46,343,295

G

xanthine dehydrogenase

multiple interactions

caffeic acid inhibits the reaction [Tetradecanoylphorbol Acetate promotes the reaction [XDH protein results in increased chemical synthesis of Uric Acid]]; caffeic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of XDH protein]

NCBI chr17:74,190,890...74,257,191
Ensembl chr17:74,190,890...74,257,191

curcumin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

alpha 1,4-galactosyltransferase

multiple interactions

Curcumin inhibits the reaction [IL1B protein results in increased expression of A4GALT mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of A4GALT mRNA]

NCBI chr15:83,110,923...83,135,930
Ensembl chr15:83,110,923...83,135,975

G

alanyl-tRNA synthetase 1

decreases expression

Curcumin results in decreased expression of AARS1 mRNA

NCBI chr 8:111,759,781...111,784,237
Ensembl chr 8:111,759,776...111,784,296

G

ATP-binding cassette, sub-family A member 1

multiple interactions

Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in decreased expression of ABCA1 mRNA]; Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in decreased expression of ABCA1 protein]; MIR125A mRNA inhibits the reaction [Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in decreased expression of ABCA1 mRNA]]; MIR125A mRNA inhibits the reaction [Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in decreased expression of ABCA1 protein]]; SIRT6 protein promotes the reaction [Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in decreased expression of ABCA1 mRNA]]; SIRT6 protein promotes the reaction [Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in decreased expression of ABCA1 protein]]

NCBI chr 4:53,030,789...53,159,988
Ensembl chr 4:53,030,787...53,159,895

G

ATP-binding cassette, sub-family B member 1A

decreases expression
decreases response to substance
affects response to substance
multiple interactions

Curcumin analog results in decreased expression of ABCB1 protein; Curcumin results in decreased expression of ABCB1 mRNA; Curcumin results in decreased expression of ABCB1B mRNA
ABCB1 protein results in decreased susceptibility to Curcumin
ABCB1 affects the susceptibility to Curcumin
[Curcumin co-treated with Calcitriol] inhibits the reaction [Paclitaxel results in increased expression of ABCB1 protein]; Calcitriol promotes the reaction [Curcumin inhibits the reaction [Paclitaxel results in increased expression of ABCB1 protein]]; Curcumin inhibits the reaction [Paclitaxel results in increased expression of ABCB1 protein]; Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of ABCB1 mRNA]
[Calcitriol co-treated with Curcumin] inhibits the reaction [Paclitaxel results in increased expression of ABCB1 protein]; [Curcumin co-treated with Calcitriol] inhibits the reaction [Paclitaxel results in increased expression of ABCB1 mRNA]; [Curcumin co-treated with Paclitaxel] results in increased expression of ABCB1 protein; [sulfinosine co-treated with Curcumin] results in decreased expression of ABCB1 mRNA; Calcitriol inhibits the reaction [[Curcumin co-treated with Paclitaxel] results in increased expression of ABCB1 protein]; Curcumin analog inhibits the reaction [ABCB1 protein results in decreased susceptibility to Paclitaxel]; Curcumin analog inhibits the reaction [ABCB1 protein results in decreased susceptibility to Vinblastine]; Curcumin inhibits the reaction [[Calcitriol co-treated with Paclitaxel] results in increased expression of ABCB1 mRNA]; Curcumin inhibits the reaction [[Calcitriol co-treated with Paclitaxel] results in increased expression of ABCB1 protein]; Curcumin inhibits the reaction [ABCB1 protein results in decreased susceptibility to Paclitaxel]; Curcumin inhibits the reaction [ABCB1 protein results in decreased susceptibility to Vinblastine]; Curcumin inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; Curcumin inhibits the reaction [Paclitaxel results in increased expression of ABCB1 mRNA]; Curcumin inhibits the reaction [Paclitaxel results in increased expression of ABCB1 protein]; Curcumin results in decreased expression of and results in decreased activity of ABCB1 protein

PMID:15476675 PMID:17121181 PMID:18200517 PMID:18385293 PMID:18414057 More...

NCBI chr 5:8,617,091...8,798,575
Ensembl chr 5:8,710,077...8,798,575

G

ATP-binding cassette, sub-family B member 1B

multiple interactions
decreases expression

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Curcumin results in decreased expression of ABCB1B protein]; [Curcumin results in decreased expression of ABCB1B protein] which results in increased susceptibility to Doxorubicin; Curcumin inhibits the reaction [[NFKB1 protein binds to RELA protein] which results in increased expression of ABCB1B mRNA]
Curcumin results in decreased expression of ABCB1B mRNA; Curcumin results in decreased expression of ABCB1B protein

NCBI chr 5:8,848,147...8,916,314
Ensembl chr 5:8,848,147...8,916,315

G

ATP-binding cassette, sub-family C member 1

decreases activity
decreases expression

Curcumin results in decreased activity of ABCC1 protein
Curcumin analog results in decreased expression of ABCC1 mRNA

PMID:15885658 PMID:16021489 PMID:26409325

NCBI chr16:14,179,317...14,292,743
Ensembl chr16:14,179,422...14,293,601

G

ATP-binding cassette, sub-family member 2

decreases activity
multiple interactions

Curcumin results in decreased activity of ABCC2 protein
[Curcumin co-treated with Acetaminophen] results in increased expression of ABCC2 mRNA; [Curcumin co-treated with Acetaminophen] results in increased expression of ABCC2 protein

PMID:15885658 PMID:35243748

NCBI chr19:43,770,747...43,826,771
Ensembl chr19:43,770,631...43,829,179

G

ATP-binding cassette, sub-family C member 4

multiple interactions

[Curcumin co-treated with Acetaminophen] results in increased expression of ABCC4 mRNA; [Curcumin co-treated with Acetaminophen] results in increased expression of ABCC4 protein

NCBI chr14:118,720,104...118,945,475
Ensembl chr14:118,720,104...118,943,631

G

ATP-binding cassette, sub-family C member 5

multiple interactions

[Curcumin analog binds to and results in decreased activity of ABCC5 protein] which results in decreased export of Hyaluronic Acid; [Curcumin binds to and results in decreased activity of ABCC5 protein] which results in decreased export of Hyaluronic Acid; Curcumin analog binds to and results in decreased activity of ABCC5 protein; Curcumin analog inhibits the reaction [ABCC5 protein results in increased export of Hyaluronic Acid]; Curcumin binds to and results in decreased activity of ABCC5 protein; Curcumin inhibits the reaction [ABCC5 protein results in increased export of Hyaluronic Acid]

NCBI chr16:20,150,053...20,245,178
Ensembl chr16:20,150,053...20,245,144

G

ATP binding cassette subfamily G member 1

increases expression

Curcumin results in increased expression of ABCG1 mRNA

PMID:16713233 PMID:21594647

NCBI chr17:31,276,668...31,336,958
Ensembl chr17:31,276,649...31,336,962

G

ATP binding cassette subfamily G member 2 (Junior blood group)

multiple interactions
decreases expression
increases expression

AHR protein promotes the reaction [Curcumin results in increased expression of ABCG2 protein]
Curcumin results in decreased expression of ABCG2 mRNA

PMID:17077187 PMID:33539684

NCBI chr 6:58,561,476...58,669,436
Ensembl chr 6:58,561,508...58,672,661

G

acetyl-Coenzyme A carboxylase alpha

increases phosphorylation
decreases expression
affects expression
multiple interactions

Curcumin results in increased phosphorylation of ACACA protein
Curcumin results in decreased expression of ACACA mRNA
Curcumin affects the expression of ACACA mRNA
Curcumin inhibits the reaction [bisphenol A results in increased expression of ACACA mRNA]; Curcumin inhibits the reaction [bisphenol A results in increased expression of ACACA protein]; Curcumin inhibits the reaction [Dietary Fats results in decreased phosphorylation of ACACA protein]

PMID:18790744 PMID:19297423 PMID:27208389 PMID:37701206

NCBI chr11:84,020,461...84,292,477
Ensembl chr11:84,020,498...84,292,477

G

angiotensin I converting enzyme

multiple interactions

Curcumin inhibits the reaction [Paraquat affects the expression of ACE protein]

NCBI chr11:105,858,774...105,880,790
Ensembl chr11:105,858,771...105,880,790

G

angiotensin converting enzyme 2

multiple interactions
affects binding

Curcumin inhibits the reaction [AGT protein results in increased expression of ACE2 protein]
Curcumin binds to ACE2 protein

PMID:26648693 PMID:34138966

NCBI chr X:162,922,338...162,971,414
Ensembl chr X:162,922,328...162,971,416

G

acetylcholinesterase

multiple interactions
decreases activity

[Curcumin co-treated with Niacin co-treated with ZM 241385] inhibits the reaction [Rotenone results in increased expression of ACHE protein]; Curcumin inhibits the reaction [Rotenone results in decreased activity of ACHE protein]; Curcumin inhibits the reaction [Rotenone results in increased expression of ACHE protein]; Curcumin inhibits the reaction [Streptozocin results in increased activity of ACHE protein]
Curcumin inhibits the reaction [Hypochlorous Acid results in decreased activity of ACHE protein]
Curcumin results in decreased activity of ACHE protein
Curcumin inhibits the reaction [Acrylamide results in increased activity of ACHE protein]; Curcumin inhibits the reaction [aluminum acetate results in decreased activity of ACHE protein]; Curcumin inhibits the reaction [cadmium sulfate results in increased expression of ACHE mRNA]; Curcumin inhibits the reaction [cadmium sulfate results in increased expression of ACHE protein]; Curcumin inhibits the reaction [lead acetate results in decreased activity of ACHE protein]; Curcumin inhibits the reaction [sodium arsenite results in decreased activity of ACHE protein]; pralidoxime promotes the reaction [[Atropine co-treated with Curcumin] inhibits the reaction [Dichlorvos results in decreased activity of ACHE protein]]

PMID:18809455 PMID:20369229 PMID:21839772 PMID:22783142 PMID:25199698 More...

NCBI chr 5:137,286,516...137,292,728
Ensembl chr 5:137,285,781...137,292,728

G

atypical chemokine receptor 3

increases expression

Curcumin results in increased expression of ACKR3 mRNA

NCBI chr 1:90,131,702...90,143,446
Ensembl chr 1:90,131,702...90,144,473

G

ATP citrate lyase

affects expression
decreases expression

Curcumin affects the expression of ACLY mRNA
Curcumin results in decreased expression of ACLY mRNA

NCBI chr11:100,367,178...100,418,826
Ensembl chr11:100,367,179...100,418,826

G

aconitase 2, mitochondrial

multiple interactions

Curcumin inhibits the reaction [Potassium Dichromate results in decreased activity of ACO2 protein]

NCBI chr15:81,756,664...81,799,338
Ensembl chr15:81,756,510...81,799,334

G

actin alpha 2, smooth muscle, aorta

multiple interactions
decreases expression

[Arsenic Trioxide co-treated with Curcumin] inhibits the reaction [Cisplatin results in increased expression of ACTA2 mRNA]; Arsenic Trioxide promotes the reaction [Curcumin inhibits the reaction [Cisplatin results in increased expression of ACTA2 protein]]; Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 mRNA]; Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein]; Curcumin inhibits the reaction [Cisplatin results in increased expression of ACTA2 mRNA]; Curcumin inhibits the reaction [Cisplatin results in increased expression of ACTA2 protein]; Curcumin inhibits the reaction [Thioacetamide results in increased expression of ACTA2 mRNA]; Curcumin inhibits the reaction [Thioacetamide results in increased expression of ACTA2 protein]; Curcumin promotes the reaction [Arsenic Trioxide inhibits the reaction [Cisplatin results in increased expression of ACTA2 protein]]; pomegranate fruit rind promotes the reaction [Curcumin inhibits the reaction [Thioacetamide results in increased expression of ACTA2 mRNA]]
Curcumin inhibits the reaction [Bleomycin results in increased expression of ACTA2 mRNA]; Curcumin inhibits the reaction [Thioacetamide results in increased expression of ACTA2 protein]
Curcumin results in decreased expression of ACTA2 mRNA; Curcumin results in decreased expression of ACTA2 protein

PMID:17355460 PMID:17531121 PMID:18006644 PMID:22683883 PMID:27363783 More...

NCBI chr19:34,217,736...34,232,985
Ensembl chr19:34,218,490...34,232,990

G

a disintegrin and metallopeptidase domain 17

multiple interactions

Curcumin inhibits the reaction [TNF protein results in increased expression of ADAM17 mRNA]

NCBI chr12:21,373,510...21,423,633
Ensembl chr12:21,373,510...21,423,633

G

ADAM metallopeptidase with thrombospondin type 1 motif 4

increases expression

Curcumin results in increased expression of ADAMTS4 mRNA

NCBI chr 1:171,077,698...171,089,836
Ensembl chr 1:171,077,990...171,088,206

G

adenylate cyclase 9

decreases expression

Curcumin results in decreased expression of ADCY9 mRNA

NCBI chr16:4,102,750...4,255,094
Ensembl chr16:4,105,393...4,238,362

G

adhesion G protein-coupled receptor E1

decreases expression

Curcumin results in decreased expression of ADGRE1 mRNA

NCBI chr17:57,665,650...57,790,527
Ensembl chr17:57,665,691...57,790,527

G

adiponectin, C1Q and collagen domain containing

increases expression
multiple interactions
affects expression

Curcumin results in increased expression of ADIPOQ mRNA; Curcumin results in increased expression of ADIPOQ protein
Curcumin inhibits the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of ADIPOQ mRNA]; Curcumin inhibits the reaction [butylbenzyl phthalate promotes the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of ADIPOQ mRNA]]
Curcumin affects the expression of ADIPOQ mRNA
Curcumin inhibits the reaction [Fructose results in decreased expression of ADIPOQ protein]

PMID:18403477 PMID:26713546 PMID:27208389 PMID:28595985

NCBI chr16:22,965,286...22,976,718
Ensembl chr16:22,965,286...22,976,778

G

adenosine A2a receptor

multiple interactions

[Curcumin co-treated with Niacin co-treated with ZM 241385] inhibits the reaction [Rotenone results in increased expression of ADORA2A mRNA]; Curcumin inhibits the reaction [Rotenone results in increased expression of ADORA2A mRNA]

NCBI chr10:75,152,711...75,170,626
Ensembl chr10:75,152,711...75,170,618

G

advanced glycosylation end product-specific receptor

multiple interactions

2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of AGER protein]]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of AGER protein]

NCBI chr17:34,816,545...34,819,911
Ensembl chr17:34,816,836...34,819,910

G

anterior gradient 2

decreases expression

Curcumin results in decreased expression of AGR2 mRNA

NCBI chr12:36,042,924...36,054,080
Ensembl chr12:36,042,906...36,054,086

G

angiotensinogen

multiple interactions

[Curcumin binds to carboxymethyl-chitosan analog] inhibits the reaction [AGT protein modified form results in decreased degradation of TP53 protein]; [Curcumin binds to carboxymethyl-chitosan analog] inhibits the reaction [AGT protein modified form results in increased expression of and results in increased phosphorylation of RELA protein]; [Curcumin binds to carboxymethyl-chitosan analog] inhibits the reaction [AGT protein modified form results in increased expression of KIT protein]; [Curcumin binds to carboxymethyl-chitosan analog] inhibits the reaction [AGT protein modified form results in increased expression of PCNA protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[Curcumin binds to carboxymethyl-chitosan analog] inhibits the reaction [AGT protein modified form results in decreased degradation of TP53 protein]]; carboxymethyl-chitosan analog promotes the reaction [Curcumin inhibits the reaction [AGT protein modified form results in increased acetylation of TP53 protein]]; carboxymethyl-chitosan analog promotes the reaction [Curcumin inhibits the reaction [AGT protein modified form results in increased expression of BAX protein]]; carboxymethyl-chitosan analog promotes the reaction [Curcumin promotes the reaction [AGT protein modified form results in increased expression of BCL2 protein]]; Curcumin inhibits the reaction [AGT protein modified form promotes the reaction [TP53 protein binds to EP300 protein]]; Curcumin inhibits the reaction [AGT protein modified form results in increased cleavage of and results in increased activity of CASP3 protein]; Curcumin inhibits the reaction [AGT protein modified form results in increased cleavage of PARP1 protein]; Curcumin inhibits the reaction [AGT protein modified form results in increased expression of and results in increased phosphorylation of and results in increased acetylation of TP53 protein]; Curcumin inhibits the reaction [AGT protein modified form results in increased expression of BAX protein]; Curcumin inhibits the reaction [AGT protein results in decreased expression of AGTR2 protein]; Curcumin inhibits the reaction [AGT protein results in increased expression of ACE2 protein]; Curcumin inhibits the reaction [AGT protein results in increased expression of TGFB1 protein]; Curcumin inhibits the reaction [AGT protein results in increased phosphorylation of SMAD2 protein]; Curcumin inhibits the reaction [AGT protein results in increased phosphorylation of SMAD3 protein]; Curcumin promotes the reaction [AGT protein modified form results in increased expression of BCL2 protein]
[Curcumin co-treated with Niacin co-treated with ZM 241385] inhibits the reaction [Rotenone results in increased expression of AGT protein]; Curcumin inhibits the reaction [Rotenone results in increased expression of AGT protein]

PMID:26612707 PMID:26648693 PMID:31820278

NCBI chr 8:125,283,326...125,296,445
Ensembl chr 8:125,283,273...125,296,445

G

angiotensin II receptor, type 2

multiple interactions

Curcumin inhibits the reaction [AGT protein results in decreased expression of AGTR2 protein]

NCBI chr X:21,350,863...21,355,072
Ensembl chr X:21,350,783...21,355,403

G

aryl-hydrocarbon receptor

multiple interactions
affects binding
increases degradation

AHR protein promotes the reaction [Curcumin results in increased expression of ABCG2 protein]
Curcumin binds to AHR protein
Curcumin results in increased degradation of AHR protein
[Curcumin co-treated with resveratrol] inhibits the reaction [Benzo(a)pyrene results in increased activity of AHR protein]; Curcumin inhibits the reaction [Benzo(a)pyrene affects the localization of AHR protein]; Curcumin inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of and results in increased activity of AHR protein]; Curcumin inhibits the reaction [Methylcholanthrene binds to AHR protein]; Curcumin inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to ARNT protein]]; Curcumin inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of [AHR protein co-treated with ARNT protein]]; Curcumin inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of AHR protein]; Curcumin promotes the reaction [Tetrachlorodibenzodioxin results in increased localization of AHR protein]

PMID:17077187 PMID:17880909 PMID:18321868 PMID:19018768 PMID:25632966

NCBI chr12:35,547,978...35,584,988
Ensembl chr12:35,547,973...35,585,037

G

adenylate kinase 1

multiple interactions

[ERBB2 protein results in increased susceptibility to Curcumin analog] which results in decreased phosphorylation of AK1 protein

NCBI chr 2:32,511,770...32,525,070
Ensembl chr 2:32,511,770...32,525,070

G

A kinase anchor protein 6

increases expression
multiple interactions

Curcumin results in increased expression of AKAP6 mRNA
Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of AKAP6 mRNA]

PMID:18200517 PMID:18421014

NCBI chr12:52,745,371...53,202,351
Ensembl chr12:52,746,166...53,202,382

G

aldo-keto reductase family 1 member B

increases expression
multiple interactions
increases activity

Curcumin results in increased expression of AKR1B1 mRNA
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Curcumin results in increased expression of AKR1B1 mRNA]; 3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [Curcumin results in increased expression of AKR1B1 mRNA]; 3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [Curcumin results in increased expression of AKR1B1 protein]; AKT1 protein affects the reaction [Curcumin results in increased expression of AKR1B1 mRNA]; NFE2L2 protein promotes the reaction [Curcumin results in increased expression of AKR1B1 mRNA]; NFE2L2 protein promotes the reaction [Curcumin results in increased expression of AKR1B1 protein]; pyrazolanthrone inhibits the reaction [Curcumin results in increased expression of AKR1B1 mRNA]; SB 203580 inhibits the reaction [Curcumin results in increased expression of AKR1B1 mRNA]
Curcumin results in increased expression of AKR1B1 mRNA; Curcumin results in increased expression of AKR1B1 protein
Curcumin results in increased activity of AKR1B1 protein

PMID:17640564 PMID:18200517 PMID:18299980 PMID:18588981

NCBI chr 6:34,280,865...34,294,424
Ensembl chr 6:34,279,369...34,294,413

G

thymoma viral proto-oncogene 1

multiple interactions
affects phosphorylation
decreases expression
decreases phosphorylation
increases expression
increases phosphorylation
decreases activity

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Curcumin results in increased phosphorylation of AKT1 protein]; 4-phenylbutyric acid inhibits the reaction [Curcumin results in decreased phosphorylation of AKT1 protein]; [bisdemethoxycurcumin co-treated with Curcumin co-treated with demethoxycurcumin] inhibits the reaction [VEGF protein results in increased phosphorylation of AKT1 protein]; Arsenic Trioxide promotes the reaction [Curcumin results in decreased phosphorylation of AKT1 protein]; calyculin A inhibits the reaction [Curcumin results in decreased phosphorylation of AKT1 protein]; Curcumin inhibits the reaction [ATF4 protein binds to AKT1 protein]; Curcumin inhibits the reaction [bisphenol A results in increased phosphorylation of AKT1 protein]; Curcumin inhibits the reaction [CXCL12 protein results in increased phosphorylation of AKT1 protein]; Curcumin inhibits the reaction [EGF protein results in increased phosphorylation of AKT1 protein]; Curcumin inhibits the reaction [IL1B protein results in increased phosphorylation of and results in increased activity of AKT1 protein]; Curcumin inhibits the reaction [Nicotine results in increased expression of AKT1 protein modified form]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of AKT1 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased activity of AKT1 protein]; Curcumin inhibits the reaction [Tunicamycin results in increased phosphorylation of AKT1 protein]; Curcumin promotes the reaction [Folfox protocol results in decreased expression of and results in decreased phosphorylation of and results in decreased activity of AKT1 protein]; Curcumin results in decreased expression of and results in decreased phosphorylation of AKT1 protein; Curcumin results in decreased expression of and results in decreased phosphorylation of and results in decreased activity of AKT1 protein; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased activity of AKT1 protein]]; lonidamine promotes the reaction [Curcumin results in decreased phosphorylation of AKT1 protein]; MIR532 affects the reaction [Curcumin results in decreased phosphorylation of AKT1 protein]
Curcumin affects the phosphorylation of AKT1 protein
Curcumin analog results in decreased expression of AKT1 mRNA; Curcumin results in decreased expression of AKT1 protein
Curcumin results in increased expression of AKT1 protein
AKT1 protein affects the reaction [Curcumin results in increased expression of AKR1B1 mRNA]; Curcumin inhibits the reaction [[Copper Sulfate results in increased abundance of Copper] which results in decreased phosphorylation of AKT1 protein]; Curcumin inhibits the reaction [sodium arsenite results in decreased phosphorylation of AKT1 protein]; Curcumin inhibits the reaction [Streptozocin results in decreased phosphorylation of AKT1 protein]; Curcumin results in decreased phosphorylation of and results in decreased activity of AKT1 protein
AKT1 protein affects the reaction [Curcumin results in increased expression of HMOX1 mRNA]; ATF4 inhibits the reaction [Curcumin results in decreased phosphorylation of AKT1 protein]
Curcumin results in decreased activity of AKT1 protein

PMID:16023083 PMID:16219905 PMID:17289836 PMID:17291458 PMID:17332930 More...

NCBI chr12:112,620,260...112,641,266
Ensembl chr12:112,620,255...112,641,318

G

thymoma viral proto-oncogene 2

multiple interactions
decreases phosphorylation
decreases expression

4-phenylbutyric acid inhibits the reaction [Curcumin results in decreased phosphorylation of AKT2 protein]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of AKT2 protein modified form]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of AKT2 protein]; Curcumin inhibits the reaction [Tunicamycin results in increased phosphorylation of AKT2 protein]; Curcumin results in decreased expression of and results in decreased phosphorylation of AKT2 protein
ATF4 inhibits the reaction [Curcumin results in decreased phosphorylation of AKT2 protein]
Curcumin analog results in decreased expression of AKT2 mRNA

PMID:23452621 PMID:26409325 PMID:36640941

NCBI chr 7:27,290,977...27,340,251
Ensembl chr 7:27,290,977...27,340,251

G

thymoma viral proto-oncogene 3

multiple interactions
decreases expression
decreases phosphorylation

ATF4 inhibits the reaction [Curcumin results in decreased phosphorylation of AKT3 protein]
Curcumin results in decreased expression of AKT3 protein
4-phenylbutyric acid inhibits the reaction [Curcumin results in decreased phosphorylation of AKT3 protein]; Curcumin inhibits the reaction [Tunicamycin results in increased phosphorylation of AKT3 protein]; Curcumin results in decreased expression of and results in decreased phosphorylation of AKT3 protein; MIR532 affects the reaction [Curcumin results in decreased expression of AKT3 protein]

PMID:36640941 PMID:37471645

NCBI chr 1:176,847,642...177,091,688
Ensembl chr 1:176,847,639...177,085,769

G

aminolevulinate, delta-, dehydratase

multiple interactions

[Curcumin co-treated with Chitosan analog] inhibits the reaction [Arsenic results in decreased activity of ALAD protein]; Curcumin inhibits the reaction [Arsenic results in decreased activity of ALAD protein]
Curcumin inhibits the reaction [lead acetate results in decreased activity of ALAD protein]

PMID:22704994 PMID:23292317

NCBI chr 4:62,422,762...62,438,300
Ensembl chr 4:62,427,406...62,438,155

G

aminolevulinic acid synthase 1

increases expression

Curcumin results in increased expression of ALAS1 mRNA

NCBI chr 9:106,110,654...106,125,153
Ensembl chr 9:106,110,654...106,125,853

G

albumin

multiple interactions

[Curcumin analog co-treated with Hydrogels] inhibits the reaction [Aflatoxin B1 results in decreased expression of ALB protein]; [Curcumin analog co-treated with Hydrogels] results in increased expression of ALB protein; Curcumin inhibits the reaction [Acetaminophen results in decreased expression of ALB protein]; Curcumin inhibits the reaction [sodium arsenite results in decreased expression of ALB protein]; Curcumin inhibits the reaction [Streptozocin results in decreased expression of ALB protein]; Curcumin inhibits the reaction [Thioacetamide results in decreased expression of ALB protein]; Curcumin inhibits the reaction [Thioacetamide results in increased expression of ALB protein]; pomegranate fruit rind promotes the reaction [Curcumin inhibits the reaction [Thioacetamide results in decreased expression of ALB protein]]

PMID:18204486 PMID:18809455 PMID:20804811 PMID:24704557 PMID:27288928 More...

NCBI chr 5:90,608,729...90,624,461
Ensembl chr 5:90,608,756...90,624,461

G

activated leukocyte cell adhesion molecule

decreases expression

Curcumin results in decreased expression of ALCAM mRNA

NCBI chr16:52,069,359...52,273,444
Ensembl chr16:52,069,359...52,274,437

G

aldehyde dehydrogenase family 1, subfamily A1

multiple interactions
decreases expression

[Calcitriol co-treated with Curcumin] inhibits the reaction [Paclitaxel results in decreased expression of ALDH1A1 protein]
[Calcitriol co-treated with Curcumin] promotes the reaction [Paclitaxel results in decreased expression of ALDH1A1 mRNA]; [Calcitriol co-treated with Paclitaxel] promotes the reaction [Curcumin results in decreased expression of ALDH1A1 mRNA]; [Curcumin co-treated with Calcitriol] inhibits the reaction [Paclitaxel results in decreased expression of ALDH1A1 protein]; [Curcumin co-treated with Paclitaxel] promotes the reaction [Calcitriol results in decreased expression of ALDH1A1 mRNA]; Curcumin promotes the reaction [Paclitaxel results in decreased expression of ALDH1A1 protein]; Paclitaxel promotes the reaction [Curcumin results in decreased expression of ALDH1A1 mRNA]
Curcumin results in decreased expression of ALDH1A1 mRNA; Curcumin results in decreased expression of ALDH1A1 protein

NCBI chr19:20,469,947...20,620,827
Ensembl chr19:20,470,079...20,620,829

G

aldolase C, fructose-bisphosphate

decreases expression

Curcumin results in decreased expression of ALDOC mRNA

NCBI chr11:78,213,899...78,218,607
Ensembl chr11:78,213,794...78,218,607

G

arachidonate 5-lipoxygenase

multiple interactions
decreases activity

[Capsaicin co-treated with Curcumin] results in decreased activity of ALOX5 protein
Curcumin results in decreased activity of ALOX5 protein

NCBI chr 6:116,387,030...116,438,139
Ensembl chr 6:116,387,038...116,438,139

G

adenosine monophosphate deaminase 1

multiple interactions

Curcumin inhibits the reaction [Hypochlorous Acid results in increased activity of AMPD1 protein]

NCBI chr 3:102,981,330...103,007,038
Ensembl chr 3:102,981,330...103,007,036

G

adenosine monophosphate deaminase 3

increases expression

Curcumin results in increased expression of AMPD3 mRNA

NCBI chr 7:110,367,291...110,411,612
Ensembl chr 7:110,367,413...110,411,612

G

ankyrin repeat domain 37

decreases expression

Curcumin results in decreased expression of ANKRD37 mRNA

NCBI chr 8:46,449,945...46,452,904
Ensembl chr 8:46,449,939...46,458,744

G

ankyrin repeat domain 50

decreases expression

Curcumin results in decreased expression of ANKRD50 mRNA

NCBI chr 3:38,503,408...38,539,005
Ensembl chr 3:38,503,408...38,538,993

G

ankyrin repeat and zinc finger domain containing 1

decreases expression

Curcumin results in decreased expression of ANKZF1 mRNA

NCBI chr 1:75,168,794...75,176,031
Ensembl chr 1:75,168,795...75,176,031

G

amine oxidase, copper-containing 1

multiple interactions

Curcumin inhibits the reaction [Methotrexate results in increased activity of AOC1 protein]
Curcumin inhibits the reaction [deoxynivalenol results in increased activity of AOC1 protein]

PMID:20885979 PMID:35817260

NCBI chr 6:48,872,189...48,886,122
Ensembl chr 6:48,849,830...48,886,122

G

apoptotic peptidase activating factor 1

increases expression
multiple interactions

Curcumin results in increased expression of APAF1 protein
Curcumin inhibits the reaction [Peroxynitrous Acid results in increased expression of APAF1 mRNA]

PMID:17277231 PMID:20869986

NCBI chr10:90,825,173...90,918,688
Ensembl chr10:90,825,173...90,918,632

G

APC, WNT signaling pathway regulator

decreases expression

Curcumin results in decreased expression of APC mRNA

NCBI chr18:34,353,350...34,455,243
Ensembl chr18:34,353,977...34,455,605

G

apolipoprotein E

affects expression

Curcumin affects the expression of APOE mRNA

NCBI chr 7:19,430,169...19,434,326
Ensembl chr 7:19,430,034...19,433,113

G

amyloid beta precursor protein

multiple interactions
increases expression

Curcumin affects the reaction [APP protein binds to APP protein]; Curcumin inhibits the reaction [Copper results in increased expression of APP mRNA]; Curcumin inhibits the reaction [Hydrogen Peroxide results in increased expression of APP mRNA]; Curcumin inhibits the reaction [Paraquat results in increased expression of APP mRNA]; Curcumin inhibits the reaction [Paraquat results in increased expression of APP protein]
Curcumin results in increased expression of APP mRNA
[Curcumin analog co-treated with APP protein modified form] results in increased expression of NFE2L2 protein; [Curcumin co-treated with APP protein modified form] results in increased expression of NFE2L2 protein; Curcumin analog inhibits the reaction [APP protein modified form results in decreased activity of CAT protein]; Curcumin analog promotes the reaction [APP protein modified form results in decreased expression of KEAP1 protein]; Curcumin inhibits the reaction [APP protein modified form results in decreased activity of CAT protein]; Curcumin promotes the reaction [APP protein modified form results in decreased expression of KEAP1 protein]

PMID:18537544 PMID:18583042 PMID:27793699 PMID:30946834 PMID:31521693

NCBI chr16:84,751,236...84,972,187
Ensembl chr16:84,746,573...84,970,654

G

aquaporin 3

decreases expression
multiple interactions

Curcumin results in decreased expression of AQP3 protein
Curcumin inhibits the reaction [EGF protein results in increased expression of AQP3 protein]

NCBI chr 4:41,092,724...41,098,183
Ensembl chr 4:41,092,722...41,098,183

G

aquaporin 9

increases expression

Curcumin results in increased expression of AQP9 mRNA; Curcumin results in increased expression of AQP9 protein

NCBI chr 9:71,017,941...71,075,170
Ensembl chr 9:71,017,941...71,075,964

G

androgen receptor

multiple interactions
increases expression
decreases activity
decreases expression

[[Quercetin co-treated with Curcumin] results in decreased methylation of AR promoter] which results in increased expression of AR mRNA; [[Quercetin co-treated with Curcumin] results in decreased methylation of AR promoter] which results in increased expression of AR protein; [Quercetin co-treated with Curcumin] results in decreased methylation of AR promoter; AR protein affects the reaction [[Curcumin co-treated with Quercetin] results in increased expression of BAX protein]; AR protein affects the reaction [[Curcumin co-treated with Quercetin] results in increased expression of CASP3 protein]; AR protein affects the reaction [[Curcumin co-treated with Quercetin] results in increased expression of CDKN1A protein]; AR protein affects the reaction [[Curcumin co-treated with Quercetin] results in increased expression of CDKN1B protein]; Curcumin inhibits the reaction [AR protein results in increased expression of KLK3 mRNA]; Curcumin inhibits the reaction [Dihydrotestosterone promotes the reaction [AR protein binds to KLK3 enhancer]]; Curcumin inhibits the reaction [Dihydrotestosterone promotes the reaction [AR protein binds to TMPRSS2 enhancer]]; Curcumin inhibits the reaction [IL6 protein results in increased expression of AR mRNA]; Curcumin inhibits the reaction [IL6 protein results in increased expression of AR protein]; Curcumin promotes the reaction [Quercetin results in increased expression of AR mRNA]; Curcumin promotes the reaction [Quercetin results in increased expression of AR protein]; Quercetin promotes the reaction [Curcumin results in increased expression of AR mRNA]; Quercetin promotes the reaction [Curcumin results in increased expression of AR protein]
Curcumin results in increased expression of AR mRNA; Curcumin results in increased expression of AR protein
Curcumin results in decreased activity of AR protein
Curcumin results in decreased expression of AR mRNA; Curcumin results in decreased expression of AR protein

PMID:12497104 PMID:18676361 PMID:18719366 PMID:22258452 PMID:27132804

NCBI chr X:97,192,363...97,366,824
Ensembl chr X:97,192,375...97,366,821

G

Rho GTPase activating protein 24

multiple interactions

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of ARHGAP24 mRNA]

NCBI chr 5:102,355,043...103,053,743
Ensembl chr 5:102,629,257...103,045,803

G

Rho GTPase activating protein 30

decreases expression

Curcumin results in decreased expression of ARHGAP30 mRNA

NCBI chr 1:171,216,528...171,237,808
Ensembl chr 1:171,216,522...171,237,866

G

Rho, GDP dissociation inhibitor beta

multiple interactions

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of ARHGDIB mRNA]

NCBI chr 6:136,900,653...136,918,895
Ensembl chr 6:136,900,653...136,918,897

G

aryl hydrocarbon receptor nuclear translocator

multiple interactions
increases degradation
decreases expression

Acetylcysteine inhibits the reaction [Curcumin results in increased degradation of ARNT protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Curcumin results in increased degradation of ARNT protein]; Curcumin results in increased ubiquitination of and results in increased degradation of ARNT protein
Curcumin inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to ARNT protein]]; Curcumin inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of [AHR protein co-treated with ARNT protein]]; Curcumin inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of ARNT protein]
Curcumin results in decreased expression of ARNT protein

PMID:16880289 PMID:17880909 PMID:18682687 PMID:19018768

NCBI chr 3:95,341,674...95,404,551
Ensembl chr 3:95,341,699...95,404,551

G

activating transcription factor 1

multiple interactions

Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of ATF1 mRNA]

NCBI chr15:100,125,729...100,159,129
Ensembl chr15:100,125,700...100,159,125

G

activating transcription factor 2

decreases expression

Curcumin analog results in decreased expression of ATF2 mRNA

NCBI chr 2:73,646,853...73,723,094
Ensembl chr 2:73,646,853...73,722,983

G

activating transcription factor 3

increases expression

Curcumin results in increased expression of ATF3 mRNA; Curcumin results in increased expression of ATF3 protein

PMID:15713895 PMID:18555241 PMID:18719366

NCBI chr 1:190,902,493...190,915,530
Ensembl chr 1:190,902,493...190,950,236

G

activating transcription factor 4

multiple interactions
decreases expression

ATF4 inhibits the reaction [Curcumin results in decreased phosphorylation of AKT1 protein]; ATF4 inhibits the reaction [Curcumin results in decreased phosphorylation of AKT2 protein]; ATF4 inhibits the reaction [Curcumin results in decreased phosphorylation of AKT3 protein]; ATF4 inhibits the reaction [Curcumin results in decreased phosphorylation of MTOR protein]
ATF4 inhibits the reaction [Curcumin results in decreased expression of ATF4 protein]; ATF4 inhibits the reaction [Curcumin results in decreased expression of HK2 protein]; ATF4 inhibits the reaction [Curcumin results in decreased expression of LDHA protein]; ATF4 inhibits the reaction [Curcumin results in decreased expression of PKM protein]; ATF4 inhibits the reaction [Curcumin results in decreased expression of SLC2A1 protein]; Curcumin inhibits the reaction [ATF4 protein binds to AKT1 protein]; Curcumin inhibits the reaction [ATF4 protein binds to ATG4B protein]; Curcumin inhibits the reaction [Tunicamycin results in increased expression of ATF4 protein]

NCBI chr15:80,139,385...80,141,746
Ensembl chr15:80,139,385...80,141,742

G

activating transcription factor 6

increases expression

Curcumin results in increased expression of ATF6 protein
Curcumin results in increased expression of ATF6 mRNA

PMID:21793155 PMID:29723631

NCBI chr 1:170,532,026...170,696,414
Ensembl chr 1:170,532,243...170,695,340

G

autophagy related 4B, cysteine peptidase

decreases expression
multiple interactions

Curcumin results in decreased expression of ATG4B protein
4-phenylbutyric acid inhibits the reaction [Curcumin results in decreased expression of ATG4B protein]; Curcumin inhibits the reaction [ATF4 protein binds to ATG4B protein]; Curcumin inhibits the reaction [Tunicamycin results in increased expression of ATG4B protein]

NCBI chr 1:93,682,627...93,717,328
Ensembl chr 1:93,679,222...93,718,332

G

autophagy related 5

decreases expression
multiple interactions

Curcumin results in decreased expression of ATG5 protein
Curcumin inhibits the reaction [Tunicamycin results in increased expression of ATG5 protein]

NCBI chr10:44,144,325...44,240,295
Ensembl chr10:44,144,354...44,240,287

G

ataxia telangiectasia mutated

multiple interactions
increases phosphorylation

[Isoflavones co-treated with Curcumin] results in increased phosphorylation of ATM protein
Curcumin results in increased phosphorylation of ATM protein

PMID:19401701 PMID:21134073

NCBI chr 9:53,348,422...53,448,125
Ensembl chr 9:53,350,449...53,448,040

G

aurora kinase A

decreases expression

Curcumin analog results in decreased expression of AURKA mRNA

NCBI chr 2:172,198,116...172,212,825
Ensembl chr 2:172,198,110...172,212,455

G

aurora kinase B

decreases expression

Curcumin analog results in decreased expression of AURKB mRNA

NCBI chr11:68,936,477...68,942,490
Ensembl chr11:68,936,473...68,942,490

G

axin 1

multiple interactions
increases expression

Curcumin inhibits the reaction [bisphenol A results in decreased expression of AXIN1 mRNA]
Curcumin results in increased expression of AXIN1 mRNA

NCBI chr17:26,350,294...26,414,784
Ensembl chr17:26,357,662...26,414,785

G

UDP-Gal:betaGal beta 1,3-galactosyltransferase, polypeptide 6

increases expression

Curcumin results in increased expression of B3GALT6 mRNA

NCBI chr 4:156,073,923...156,077,135
Ensembl chr 4:156,073,923...156,077,106

G

beta-site APP cleaving enzyme 1

multiple interactions
increases expression

Curcumin inhibits the reaction [Copper results in increased expression of BACE1 mRNA]; Curcumin inhibits the reaction [Hydrogen Peroxide results in increased expression of BACE1 mRNA]
Curcumin results in increased expression of BACE1 mRNA

PMID:18583042 PMID:31521693

NCBI chr 9:45,749,878...45,775,694
Ensembl chr 9:45,749,878...45,775,697

G

BCL2-associated agonist of cell death

increases expression
multiple interactions

Curcumin results in increased expression of BAD mRNA; Curcumin results in increased expression of BAD protein
[arsenic trioxide co-treated with Curcumin] results in increased expression of BAD protein
Curcumin inhibits the reaction [tert-Butylhydroperoxide results in increased expression of BAD protein]

PMID:15569404 PMID:19235267 PMID:27430728

NCBI chr19:6,919,229...6,929,273
Ensembl chr19:6,919,229...6,929,267

G

BCL2-antagonist/killer 1

multiple interactions
decreases expression
increases expression
increases response to substance

TNFSF10 protein promotes the reaction [Curcumin results in increased expression of BAK1 protein]
Curcumin results in decreased expression of BAK1 mRNA
Curcumin results in increased expression of BAK1 mRNA; Curcumin results in increased expression of BAK1 protein
BAK1 protein results in increased susceptibility to Curcumin

PMID:17277231 PMID:17332930 PMID:18226269 PMID:33582110

NCBI chr17:27,238,786...27,247,601
Ensembl chr17:27,238,784...27,247,983

G

BCL2-associated X protein

multiple interactions
affects expression
decreases expression
increases expression
affects localization
increases response to substance

[Arsenic Trioxide co-treated with Curcumin] results in increased expression of BAX protein; [bicalutamide co-treated with Curcumin co-treated with Quercetin] results in increased expression of BAX protein; [Curcumin co-treated with Arsenic Trioxide] results in increased expression of BAX protein; [Curcumin co-treated with Quercetin] results in increased expression of BAX protein; [Curcumin co-treated with Sirolimus] results in increased expression of BAX; [Doxorubicin co-treated with Curcumin] results in increased expression of BAX mRNA; AR protein affects the reaction [[Curcumin co-treated with Quercetin] results in increased expression of BAX protein]; Arsenic Trioxide promotes the reaction [Curcumin affects the localization of BAX protein]; Curcumin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of BAX protein]; Curcumin inhibits the reaction [bisphenol A results in decreased expression of BAX protein]; Curcumin inhibits the reaction [Paraquat results in increased expression of BAX protein]; Curcumin promotes the reaction [Arsenic Trioxide affects the localization of BAX protein]; Curcumin promotes the reaction [lonidamine affects the localization of BAX protein]; Curcumin promotes the reaction [Paclitaxel promotes the reaction [Calcitriol results in increased expression of BAX protein]]; Curcumin promotes the reaction [Paclitaxel results in increased expression of BAX protein]; Dihydrotestosterone inhibits the reaction [[Curcumin co-treated with Quercetin] results in increased expression of BAX protein]; lonidamine promotes the reaction [Curcumin affects the localization of BAX protein]; Paclitaxel promotes the reaction [Curcumin results in increased expression of BAX protein]; piperine inhibits the reaction [Curcumin results in decreased expression of BAX protein]; TNFSF10 protein promotes the reaction [Curcumin results in increased expression of BAX protein]; Vitamin E inhibits the reaction [Curcumin results in decreased expression of BAX protein]
Curcumin affects the expression of BAX protein
Curcumin results in decreased expression of BAX mRNA; Curcumin results in decreased expression of BAX protein
Curcumin results in increased expression of BAX mRNA; Curcumin results in increased expression of BAX protein
2-chloro-5-nitrobenzanilide inhibits the reaction [Curcumin results in increased expression of BAX mRNA]; 2-chloro-5-nitrobenzanilide inhibits the reaction [Curcumin results in increased expression of BAX protein]; [Curcumin analog co-treated with Hydrogels] inhibits the reaction [Aflatoxin B1 results in increased expression of BAX mRNA]; carboxymethyl-chitosan analog promotes the reaction [Curcumin inhibits the reaction [AGT protein modified form results in increased expression of BAX protein]]; carboxymethyl-chitosan analog promotes the reaction [Curcumin results in decreased expression of BAX protein]; Curcumin inhibits the reaction [[Copper Sulfate results in increased abundance of Copper] which results in increased expression of BAX mRNA]; Curcumin inhibits the reaction [AGT protein modified form results in increased expression of BAX protein]; Curcumin inhibits the reaction [aristolochic acid I results in increased expression of BAX mRNA]; Curcumin inhibits the reaction [bisphenol A results in increased expression of BAX mRNA]; Curcumin inhibits the reaction [Ketamine results in increased expression of BAX mRNA]; Curcumin inhibits the reaction [Ketamine results in increased expression of BAX protein]; Curcumin inhibits the reaction [Peroxynitrous Acid results in increased expression of BAX mRNA]; Curcumin inhibits the reaction [Peroxynitrous Acid results in increased expression of BAX protein]; Curcumin inhibits the reaction [sodium arsenite results in increased expression of BAX protein]; Curcumin inhibits the reaction [Streptozocin affects the expression of BAX protein]; Curcumin inhibits the reaction [Streptozocin results in increased expression of BAX mRNA]; Curcumin inhibits the reaction [tert-Butylhydroperoxide results in increased expression of BAX protein]
BAX protein results in increased susceptibility to Curcumin
[Curcumin co-treated with Quercetin] inhibits the reaction [Benzo(a)pyrene results in decreased expression of BAX protein]; Curcumin affects the localization of and results in increased expression of and results in increased activity of BAX protein; Curcumin inhibits the reaction [Benzo(a)pyrene results in decreased expression of BAX protein]; Curcumin inhibits the reaction [deoxynivalenol results in increased expression of BAX mRNA]; Curcumin inhibits the reaction [deoxynivalenol results in increased expression of BAX protein]

PMID:15569404 PMID:17096185 PMID:17277231 PMID:17332930 PMID:17531121 More...

NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322

G

BCL2 binding component 3

increases expression
multiple interactions
decreases expression

Curcumin results in increased expression of BBC3 mRNA
Curcumin inhibits the reaction [Doxorubicin results in increased expression of BBC3 protein]
Curcumin results in decreased expression of BBC3 mRNA

PMID:17332930 PMID:22714040 PMID:34047412

NCBI chr 7:16,042,307...16,052,130
Ensembl chr 7:16,042,318...16,052,130

G

B cell leukemia/lymphoma 10

multiple interactions

Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of BCL10 mRNA]

NCBI chr 3:145,630,017...145,640,121
Ensembl chr 3:145,628,559...145,640,111

G

B cell leukemia/lymphoma 2

multiple interactions
increases expression
decreases expression

[Arsenic Trioxide co-treated with Curcumin] affects the expression of BCL2 protein; [Curcumin binds to 4-bis(2-chloroethyl)aminobenzaldehyde] which results in decreased expression of BCL2 protein; [Curcumin co-treated with Arsenic Trioxide] results in decreased expression of BCL2 protein; [Curcumin co-treated with Calcitriol] promotes the reaction [Paclitaxel results in decreased expression of BCL2 protein]; [Curcumin co-treated with Isoflavones] results in decreased expression of BCL2 protein; [Curcumin co-treated with Sirolimus] results in decreased expression of BCL2; [Curcumin results in increased expression of SERPINB5] which results in decreased expression of BCL2 protein; [Dihydrotestosterone co-treated with Curcumin co-treated with Quercetin] results in increased expression of BCL2 protein; [Doxorubicin co-treated with Curcumin] results in decreased expression of BCL2 mRNA; [piperine co-treated with Curcumin] results in decreased expression of BCL2 protein; [Vitamin E co-treated with Curcumin] results in decreased expression of BCL2 protein; Curcumin inhibits the reaction [Docetaxel results in increased phosphorylation of BCL2 protein]; Curcumin inhibits the reaction [Nicotine results in increased expression of BCL2 protein]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of BCL2 mRNA]; Curcumin inhibits the reaction [Paclitaxel results in increased expression of BCL2 protein]; Curcumin inhibits the reaction [TNF protein results in increased expression of BCL2 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of BCL2 protein]; Curcumin promotes the reaction [Calcitriol promotes the reaction [Paclitaxel results in decreased expression of BCL2 protein]]; Curcumin promotes the reaction [Paclitaxel results in decreased expression of BCL2 protein]; Curcumin promotes the reaction [sodium arsenite results in decreased expression of BCL2 protein]; Curcumin results in increased ubiquitination of and results in increased degradation of BCL2 protein; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased expression of BCL2 protein]]; manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [Curcumin results in increased ubiquitination of and results in increased degradation of BCL2 protein]; NFE2L2 protein affects the reaction [Curcumin promotes the reaction [sodium arsenite results in decreased expression of BCL2 protein]]; TNFSF10 protein promotes the reaction [Curcumin results in decreased expression of BCL2 protein]
Curcumin results in increased expression of BCL2 mRNA; Curcumin results in increased expression of BCL2 protein
Curcumin results in decreased expression of BCL2 mRNA; Curcumin results in decreased expression of BCL2 protein
Curcumin analog results in decreased expression of BCL2 mRNA; Curcumin results in decreased expression of BCL2 mRNA; Curcumin results in decreased expression of BCL2 protein
[Curcumin co-treated with Gemcitabine] results in decreased expression of BCL2 protein; [Quercetin co-treated with Curcumin] inhibits the reaction [Benzo(a)pyrene results in increased expression of BCL2 protein]; Curcumin inhibits the reaction [Benzo(a)pyrene results in increased expression of BCL2 protein]; Curcumin inhibits the reaction [deoxynivalenol results in decreased expression of BCL2 mRNA]; Curcumin inhibits the reaction [deoxynivalenol results in decreased expression of BCL2 protein]; NFE2L2 gene mutant form inhibits the reaction [Curcumin results in increased expression of BCL2 protein]
2-chloro-5-nitrobenzanilide inhibits the reaction [Curcumin results in decreased expression of BCL2 mRNA]; 2-chloro-5-nitrobenzanilide inhibits the reaction [Curcumin results in decreased expression of BCL2 protein]; [Curcumin analog co-treated with Hydrogels] inhibits the reaction [Aflatoxin B1 results in decreased expression of BCL2 mRNA]; carboxymethyl-chitosan analog promotes the reaction [Curcumin promotes the reaction [AGT protein modified form results in increased expression of BCL2 protein]]; carboxymethyl-chitosan analog promotes the reaction [Curcumin results in increased expression of BCL2 protein]; Curcumin affects the reaction [Ketamine results in decreased expression of BCL2 protein]; Curcumin analog inhibits the reaction [Copper Sulfate results in decreased expression of BCL2 mRNA]; Curcumin inhibits the reaction [[Copper Sulfate results in increased abundance of Copper] which results in decreased expression of BCL2 mRNA]; Curcumin inhibits the reaction [aristolochic acid I results in decreased expression of BCL2 mRNA]; Curcumin inhibits the reaction [aristolochic acid I results in decreased expression of BCL2 protein]; Curcumin inhibits the reaction [bisphenol A results in decreased expression of BCL2 mRNA]; Curcumin inhibits the reaction [Colistin results in decreased expression of BCL2 protein]; Curcumin inhibits the reaction [Copper Sulfate results in decreased expression of BCL2 mRNA]; Curcumin inhibits the reaction [Cyclosporine results in decreased expression of BCL2 protein]; Curcumin inhibits the reaction [Ketamine results in decreased expression of BCL2 mRNA]; Curcumin inhibits the reaction [Peroxynitrous Acid results in decreased expression of BCL2 mRNA]; Curcumin inhibits the reaction [Peroxynitrous Acid results in decreased expression of BCL2 protein]; Curcumin inhibits the reaction [sodium arsenite results in decreased expression of BCL2 protein]; Curcumin inhibits the reaction [Streptozocin affects the expression of BCL2 protein]; Curcumin inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of BCL2 protein]; Curcumin promotes the reaction [AGT protein modified form results in increased expression of BCL2 protein]

PMID:12497104 PMID:14724571 PMID:15569404 PMID:16023083 PMID:16219905 More...

NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004

G

B cell leukemia/lymphoma 2 related protein A1b

decreases expression
multiple interactions

Curcumin results in decreased expression of BCL2A1 mRNA
Curcumin inhibits the reaction [TNF protein results in increased expression of BCL2A1 mRNA]

PMID:16219905 PMID:17596214

NCBI chr 9:89,081,326...89,089,891
Ensembl chr 9:89,081,262...89,089,880

G

BCL2-like 1

multiple interactions
decreases expression
increases expression

[Curcumin co-treated with Doxorubicin] affects the expression of BCL2L1 mRNA; [Curcumin co-treated with Isoflavones] results in decreased expression of BCL2L1 protein; Curcumin inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of BCL2L1 protein]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of BCL2L1 mRNA]; Curcumin inhibits the reaction [Paclitaxel results in increased expression of BCL2L1 protein]; Curcumin inhibits the reaction [TNF protein results in increased expression of BCL2L1 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of BCL2L1 protein]; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased expression of BCL2L1 protein]]; TNFSF10 protein promotes the reaction [Curcumin results in decreased expression of BCL2L1 protein]
Curcumin analog results in decreased expression of BCL2L1 mRNA; Curcumin results in decreased expression of BCL2L1 mRNA; Curcumin results in decreased expression of BCL2L1 protein
Curcumin inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of BCL2L1 protein]
[Curcumin co-treated with Gemcitabine] results in decreased expression of BCL2L1 protein
Curcumin results in increased expression of BCL2L1 mRNA

PMID:12497104 PMID:15569404 PMID:15911101 PMID:16023083 PMID:16173963 More...

NCBI chr 2:152,600,652...152,673,632
Ensembl chr 2:152,622,588...152,673,648

G

BCL2 like 11

increases expression
multiple interactions

Curcumin results in increased expression of BCL2L11 mRNA
[arsenic trioxide co-treated with Curcumin] results in increased expression of BCL2L11 protein

PMID:17332930 PMID:27430728

NCBI chr 2:127,967,958...128,004,467
Ensembl chr 2:127,967,958...128,004,467

G

BCL2-like 2

increases expression
multiple interactions

Curcumin results in increased expression of BCL2L2 mRNA
[arsenic trioxide co-treated with Curcumin] affects the expression of BCL2L2 protein

PMID:16101141 PMID:27430728

NCBI chr14:55,120,900...55,125,691
Ensembl chr14:55,120,834...55,125,691

G

B cell leukemia/lymphoma 3

multiple interactions

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of BCL3 mRNA]
Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of BCL3 mRNA]

PMID:18200517 PMID:23452621

NCBI chr 7:19,542,387...19,556,691
Ensembl chr 7:19,542,387...19,556,695

G

BCL6 interacting corepressor

increases expression

Curcumin results in increased expression of BCOR mRNA

NCBI chr X:11,902,976...12,026,769
Ensembl chr X:11,902,979...12,026,594

G

brain derived neurotrophic factor

multiple interactions
increases expression
affects expression

[Curcumin co-treated with Manganese] inhibits the reaction [Kainic Acid results in increased expression of BDNF mRNA]; Curcumin inhibits the reaction [[Copper Sulfate results in increased abundance of Copper] which results in increased expression of BDNF protein]; Curcumin inhibits the reaction [sodium arsenite results in decreased expression of BDNF protein]
Curcumin results in increased expression of BDNF protein
Curcumin affects the expression of BDNF protein
[Docosahexaenoic Acids co-treated with Curcumin] results in increased expression of BDNF mRNA; Curcumin inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of BDNF protein]; Curcumin inhibits the reaction [Morphine results in increased expression of BDNF mRNA]

PMID:17022948 PMID:17617388 PMID:17827730 PMID:19033880 PMID:22911773 More...

NCBI chr 2:109,505,045...109,557,388
Ensembl chr 2:109,505,045...109,557,352

G

beclin 1, autophagy related

increases expression
decreases expression

Curcumin results in increased expression of BECN1 protein
Curcumin results in decreased expression of BECN1 protein

PMID:34634291 PMID:36640941

NCBI chr11:101,179,084...101,193,112
Ensembl chr11:101,176,778...101,193,112

G

biglycan

multiple interactions

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of BGN mRNA]

NCBI chr X:72,527,207...72,539,542
Ensembl chr X:72,527,208...72,539,539

G

BH3 interacting domain death agonist

multiple interactions

[arsenic trioxide co-treated with Curcumin] results in decreased expression of BID protein; [arsenic trioxide co-treated with Curcumin] results in increased expression of BID protein; Curcumin promotes the reaction [arsenic trioxide results in increased activity of BID protein]

PMID:20605902 PMID:27430728

NCBI chr 6:120,870,080...120,894,074
Ensembl chr 6:120,868,891...120,893,814

G

baculoviral IAP repeat-containing 2

decreases expression
multiple interactions

Curcumin analog results in decreased expression of BIRC2 mRNA; Curcumin results in decreased expression of BIRC2 mRNA; Curcumin results in decreased expression of BIRC2 protein
Curcumin inhibits the reaction [Nicotine results in increased expression of BIRC2 protein]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of BIRC2 protein]; Curcumin inhibits the reaction [Paclitaxel results in increased expression of BIRC2 protein]; Curcumin inhibits the reaction [TNF protein results in increased expression of BIRC2 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of BIRC2 protein]; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased expression of BIRC2 protein]]

PMID:16023083 PMID:16219905 PMID:16243823 PMID:17596214 PMID:17640567 More...

NCBI chr 9:7,818,227...7,837,123
Ensembl chr 9:7,818,228...7,837,065

G

baculoviral IAP repeat-containing 3

multiple interactions
increases expression
decreases expression

[arsenic trioxide co-treated with Curcumin] results in decreased expression of BIRC3 protein; [Curcumin co-treated with Doxorubicin] affects the expression of BIRC3 mRNA; Curcumin inhibits the reaction [Paclitaxel results in increased expression of BIRC3 protein]; Curcumin inhibits the reaction [TNF protein results in increased expression of BIRC3 mRNA]
[Curcumin co-treated with Gemcitabine] results in decreased expression of BIRC3 protein
Curcumin results in increased expression of BIRC3 mRNA
Curcumin results in decreased expression of BIRC3 mRNA; Curcumin results in decreased expression of BIRC3 protein

PMID:15911101 PMID:16101141 PMID:16219905 PMID:16243823 PMID:17440100 More...

NCBI chr 9:7,848,698...7,873,199
Ensembl chr 9:7,848,700...7,873,187

G

baculoviral IAP repeat-containing 5

multiple interactions
decreases expression

[Arsenic Trioxide co-treated with Curcumin] results in decreased expression of BIRC5 protein; Curcumin inhibits the reaction [Benzo(a)pyrene results in decreased expression of BIRC5 protein]; Curcumin inhibits the reaction [Nicotine results in increased expression of BIRC5 protein]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of BIRC5 protein]; Curcumin inhibits the reaction [Trichloroethylene results in increased expression of BIRC5 protein]
Curcumin inhibits the reaction [Doxorubicin results in decreased expression of BIRC5 protein]
Curcumin analog results in decreased expression of BIRC5 mRNA; Curcumin results in decreased expression of BIRC5 mRNA; Curcumin results in decreased expression of BIRC5 protein
[Curcumin co-treated with Gemcitabine] results in decreased expression of BIRC5 protein

PMID:16023083 PMID:17440100 PMID:17596214 PMID:17671737 PMID:18593936 More...

NCBI chr11:117,740,063...117,746,569
Ensembl chr11:117,740,077...117,746,569

G

baculoviral IAP repeat-containing 7

increases expression
multiple interactions

Curcumin results in increased expression of BIRC7 mRNA
[arsenic trioxide co-treated with Curcumin] results in increased expression of BIRC7 protein

PMID:15911101 PMID:27430728

NCBI chr 2:180,570,402...180,575,803
Ensembl chr 2:180,570,816...180,575,803

G

bone morphogenetic protein 2

decreases expression

Curcumin results in decreased expression of BMP2 mRNA

NCBI chr 2:133,394,079...133,404,816
Ensembl chr 2:133,394,079...133,404,805

G

breast cancer 1, early onset

multiple interactions

Curcumin inhibits the reaction [Furazolidone results in increased expression of BRCA1 protein]

NCBI chr11:101,379,587...101,442,808
Ensembl chr11:101,379,590...101,442,781

G

basigin

decreases response to substance

BSG protein results in decreased susceptibility to Curcumin

NCBI chr10:79,540,192...79,547,813
Ensembl chr10:79,540,325...79,547,803

G

complement component 1, q subcomponent, alpha polypeptide

decreases expression

Curcumin results in decreased expression of C1QA mRNA

NCBI chr 4:136,623,227...136,626,155
Ensembl chr 4:136,623,228...136,626,114

G

complement component 1, q subcomponent, beta polypeptide

multiple interactions

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of C1QB mRNA]

NCBI chr 4:136,607,437...136,613,511
Ensembl chr 4:136,607,440...136,613,498

G

complement component 3

multiple interactions

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of C3 mRNA]

NCBI chr17:57,510,967...57,535,136
Ensembl chr17:57,510,970...57,535,136

G

complement C4B (Chido blood group)

multiple interactions

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of C4B mRNA]

NCBI chr17:34,947,249...34,962,876
Ensembl chr17:34,947,354...34,962,856

G

calcium/calmodulin-dependent protein kinase II alpha

multiple interactions

[Docosahexaenoic Acids co-treated with Curcumin] results in increased expression of CAMK2A mRNA
Curcumin inhibits the reaction [sodium arsenite results in decreased phosphorylation of CAMK2A protein]

PMID:22911773 PMID:29723552

NCBI chr18:61,058,704...61,121,224
Ensembl chr18:61,058,690...61,121,224

G

capping actin protein, gelsolin like

multiple interactions

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of CAPG mRNA]

NCBI chr 6:72,515,265...72,539,966
Ensembl chr 6:72,521,374...72,539,966

G

carbonic anhydrase 9

decreases expression

Curcumin results in decreased expression of CAR9 mRNA

NCBI chr 4:43,507,026...43,513,729
Ensembl chr 4:43,506,966...43,513,729

G

caspase 1

increases expression
multiple interactions

Curcumin results in increased expression of CASP1 mRNA
[Dexamethasone co-treated with Curcumin] inhibits the reaction [[Ovalbumin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased cleavage of CASP1 protein]; [Dexamethasone co-treated with Curcumin] inhibits the reaction [[Ovalbumin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of CASP1 mRNA]; Curcumin inhibits the reaction [[Ovalbumin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased cleavage of CASP1 protein]; Curcumin inhibits the reaction [[Ovalbumin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of CASP1 mRNA]; Curcumin inhibits the reaction [Aflatoxin B1 results in increased expression of CASP1 mRNA]; Curcumin inhibits the reaction [Aflatoxin B1 results in increased expression of CASP1 protein]
Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of CASP1 mRNA]

PMID:16101141 PMID:23452621 PMID:34998855 PMID:35063475

NCBI chr 9:5,298,517...5,307,281
Ensembl chr 9:5,298,508...5,307,290

G

caspase 12

increases expression
multiple interactions

Curcumin results in increased expression of CASP12 protein
Curcumin inhibits the reaction [Streptozocin results in increased cleavage of CASP12 protein]

PMID:21793155 PMID:25541178

NCBI chr 9:5,345,419...5,373,034
Ensembl chr 9:5,345,430...5,373,032

G

caspase 2

increases expression

Curcumin results in increased expression of CASP2 mRNA

NCBI chr 6:42,241,942...42,259,442
Ensembl chr 6:42,241,919...42,259,442

G

caspase 3

multiple interactions
decreases expression
increases cleavage
increases activity
decreases activity
increases expression

[Arsenic Trioxide co-treated with Curcumin] results in increased expression of CASP3 protein; [bicalutamide co-treated with Curcumin co-treated with Quercetin] results in increased expression of CASP3 protein; [Curcumin binds to 4-bis(2-chloroethyl)aminobenzaldehyde] which results in increased cleavage of CASP3 protein; [Curcumin co-treated with Arsenic Trioxide] results in decreased expression of and results in increased cleavage of CASP3 protein; [Curcumin co-treated with Arsenic Trioxide] results in increased cleavage of CASP3 protein; [Curcumin co-treated with lonidamine] results in increased cleavage of CASP3 protein; [Curcumin co-treated with Quercetin] results in increased expression of CASP3 protein; [Curcumin co-treated with Sirolimus] results in increased activity of CASP3 protein; Acetylcysteine inhibits the reaction [Curcumin results in increased activity of CASP3 protein]; AR protein affects the reaction [[Curcumin co-treated with Quercetin] results in increased expression of CASP3 protein]; Arsenic Trioxide promotes the reaction [Curcumin results in increased expression of CASP3 protein modified form]; Curcumin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of CASP3 protein modified form]; Curcumin inhibits the reaction [quinocetone results in increased activity of CASP3 protein]; Curcumin inhibits the reaction [sodium arsenite results in increased cleavage of CASP3 protein]; Curcumin promotes the reaction [Arsenic Trioxide results in increased expression of CASP3 protein modified form]; Curcumin results in increased cleavage of and results in increased activity of CASP3 protein; Dihydrotestosterone inhibits the reaction [[Curcumin co-treated with Quercetin] results in increased expression of CASP3 protein]; Glutathione inhibits the reaction [Curcumin results in increased activity of CASP3 protein]; piperine inhibits the reaction [Curcumin results in decreased expression of CASP3 protein]; Vitamin E inhibits the reaction [Curcumin results in decreased expression of CASP3 protein]; zinc protoporphyrin inhibits the reaction [Curcumin inhibits the reaction [quinocetone results in increased activity of CASP3 protein]]
Curcumin results in decreased expression of CASP3 protein modified form
Curcumin results in increased cleavage of CASP3 protein
Curcumin results in decreased activity of CASP3 protein
[Curcumin analog co-treated with Hydrogels] inhibits the reaction [Aflatoxin B1 results in increased expression of CASP3 mRNA]; Curcumin analog inhibits the reaction [Copper Sulfate results in increased secretion of CASP3 protein]; Curcumin analog inhibits the reaction [Rotenone results in increased expression of CASP3 protein modified form]; Curcumin inhibits the reaction [[Copper Sulfate results in increased abundance of Copper] which results in increased expression of CASP3 mRNA]; Curcumin inhibits the reaction [AGT protein modified form results in increased cleavage of and results in increased activity of CASP3 protein]; Curcumin inhibits the reaction [aristolochic acid I results in increased expression of and results in increased cleavage of CASP3 protein]; Curcumin inhibits the reaction [aristolochic acid I results in increased expression of CASP3 mRNA]; Curcumin inhibits the reaction [Atrazine results in increased expression of CASP3 protein]; Curcumin inhibits the reaction [bisphenol A results in increased cleavage of CASP3 protein]; Curcumin inhibits the reaction [Colistin results in increased expression of CASP3 protein]; Curcumin inhibits the reaction [Copper Sulfate results in increased secretion of CASP3 protein]; Curcumin inhibits the reaction [Cyclosporine results in increased cleavage of CASP3 protein]; Curcumin inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein]; Curcumin inhibits the reaction [Ketamine results in increased expression of CASP3 mRNA]; Curcumin inhibits the reaction [Ketamine results in increased expression of CASP3 protein modified form]; Curcumin inhibits the reaction [Ketamine results in increased expression of CASP3 protein]; Curcumin inhibits the reaction [Peroxynitrous Acid results in increased cleavage of and results in increased activity of CASP3 protein]; Curcumin inhibits the reaction [Peroxynitrous Acid results in increased expression of CASP3 mRNA]; Curcumin inhibits the reaction [Rotenone results in increased activity of CASP3 protein]; Curcumin inhibits the reaction [sodium arsenite results in increased cleavage of CASP3 protein]; Curcumin inhibits the reaction [sodium arsenite results in increased expression of CASP3 protein]; Curcumin inhibits the reaction [Streptozocin results in increased cleavage of CASP3 protein]; Curcumin inhibits the reaction [Streptozocin results in increased expression of CASP3 protein]; Curcumin inhibits the reaction [tert-Butylhydroperoxide results in increased cleavage of CASP3 protein]; Curcumin results in decreased cleavage of and results in decreased activity of CASP3 protein
[Curcumin co-treated with Gemcitabine] results in decreased expression of CASP3 protein; [Curcumin co-treated with Niacin co-treated with ZM 241385] inhibits the reaction [Rotenone results in increased activity of CASP3 protein]; [Quercetin co-treated with Curcumin] inhibits the reaction [Benzo(a)pyrene results in decreased activity of CASP3 protein]; Curcumin inhibits the reaction [Benzo(a)pyrene results in decreased activity of CASP3 protein]; Curcumin inhibits the reaction [deoxynivalenol results in increased activity of CASP3 protein]; Curcumin inhibits the reaction [Dibutyl Phthalate results in increased expression of CASP3 protein]; Curcumin inhibits the reaction [Rotenone results in increased activity of CASP3 protein]; Curcumin results in increased cleavage of and results in increased activity of CASP3 protein; NFE2L2 gene mutant form inhibits the reaction [Curcumin results in decreased expression of CASP3 protein modified form]
Curcumin results in increased expression of CASP3 mRNA; Curcumin results in increased expression of CASP3 protein; Curcumin results in increased expression of CASP3 protein modified form
Curcumin analog results in increased activity of CASP3 protein; Curcumin results in increased activity of CASP3; Curcumin results in increased activity of CASP3 protein
Curcumin results in decreased expression of CASP3 mRNA; Curcumin results in decreased expression of CASP3 protein

PMID:15095415 PMID:15569404 PMID:16023083 PMID:16101141 PMID:17041101 More...

NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724

G

caspase 4, apoptosis-related cysteine peptidase

increases expression

Curcumin results in increased expression of CASP4 mRNA

NCBI chr 9:5,308,816...5,336,791
Ensembl chr 9:5,308,828...5,336,783

G

caspase 7

multiple interactions
increases expression
decreases expression

[Calcitriol co-treated with Curcumin] promotes the reaction [Paclitaxel results in increased expression of CASP7 protein]; [Curcumin co-treated with Sirolimus] results in increased activity of CASP7 protein; Calcitriol inhibits the reaction [Curcumin inhibits the reaction [Paclitaxel results in increased expression of CASP7 protein]]; Curcumin inhibits the reaction [Calcitriol inhibits the reaction [Paclitaxel results in increased expression of CASP7 protein]]; Curcumin inhibits the reaction [Paclitaxel results in increased expression of CASP7 protein]; Curcumin results in increased cleavage of and results in increased activity of CASP7 protein
Curcumin results in increased expression of CASP7 protein
Curcumin results in decreased expression of CASP7 mRNA

PMID:16023083 PMID:16101141 PMID:19373661 PMID:31628941

NCBI chr19:56,382,640...56,430,780
Ensembl chr19:56,385,561...56,430,776

G

caspase 8

increases activity
multiple interactions
increases cleavage
decreases expression

Curcumin results in increased activity of CASP8 protein
Curcumin inhibits the reaction [Streptozocin results in increased cleavage of CASP8 protein]; Curcumin inhibits the reaction [Streptozocin results in increased expression of CASP8 mRNA]
Curcumin results in increased cleavage of CASP8 protein
Curcumin results in decreased expression of CASP8 mRNA; Curcumin results in decreased expression of CASP8 protein
[Arsenic Trioxide co-treated with Curcumin] results in increased expression of CASP8 protein; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of CASP8 mRNA]; Curcumin results in increased cleavage of and results in increased activity of CASP8 protein; N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride promotes the reaction [Curcumin results in increased cleavage of CASP8 protein]

PMID:14555224 PMID:16173963 PMID:17096185 PMID:17148446 PMID:22523229 More...

NCBI chr 1:58,834,553...58,886,663
Ensembl chr 1:58,834,533...58,886,662

G

caspase 9

decreases expression
multiple interactions
increases activity
increases expression
increases cleavage

Curcumin results in decreased expression of CASP9 mRNA; Curcumin results in decreased expression of CASP9 protein
Curcumin inhibits the reaction [aristolochic acid I results in increased expression of and results in increased cleavage of CASP9 protein]; Curcumin inhibits the reaction [aristolochic acid I results in increased expression of CASP9 mRNA]; Curcumin inhibits the reaction [Peroxynitrous Acid results in increased cleavage of and results in increased activity of CASP9 protein]; Curcumin inhibits the reaction [Peroxynitrous Acid results in increased expression of CASP9 mRNA]
Curcumin results in increased activity of CASP9 protein
Curcumin results in increased expression of CASP9 mRNA; Curcumin results in increased expression of CASP9 protein
[Curcumin co-treated with Gemcitabine] results in decreased expression of CASP9 protein; [Quercetin co-treated with Curcumin] inhibits the reaction [Benzo(a)pyrene results in decreased activity of CASP9 protein]; Curcumin inhibits the reaction [Benzo(a)pyrene results in decreased activity of CASP9 protein]; Curcumin inhibits the reaction [Dibutyl Phthalate results in increased expression of CASP9 protein]; Curcumin results in increased cleavage of and results in increased activity of CASP9 protein
Curcumin results in increased cleavage of CASP9 protein
[Curcumin co-treated with Arsenic Trioxide] results in increased cleavage of CASP9 protein; [Curcumin co-treated with Calcitriol] promotes the reaction [Paclitaxel results in increased expression of CASP9 protein]; [Curcumin co-treated with lonidamine] results in increased cleavage of CASP9 protein; [Curcumin co-treated with Sirolimus] results in increased activity of CASP9 protein; [Doxorubicin co-treated with Curcumin] results in increased expression of CASP9 mRNA; [Paclitaxel co-treated with Calcitriol] promotes the reaction [Curcumin results in increased expression of CASP9 protein]; [Paclitaxel co-treated with Curcumin] promotes the reaction [Calcitriol results in increased expression of CASP9 protein]; Curcumin inhibits the reaction [quinocetone results in increased activity of CASP9 protein]; Curcumin promotes the reaction [[Calcitriol co-treated with Paclitaxel] results in increased expression of CASP9 protein]; Curcumin results in increased cleavage of and results in increased activity of CASP9 protein; Paclitaxel promotes the reaction [Curcumin results in increased expression of CASP9 protein]; zinc protoporphyrin inhibits the reaction [Curcumin inhibits the reaction [quinocetone results in increased activity of CASP9 protein]]

PMID:14555224 PMID:16023083 PMID:16101141 PMID:17148446 PMID:17277231 More...

NCBI chr 4:141,520,923...141,543,289
Ensembl chr 4:141,520,923...141,543,287

G

catalase

multiple interactions
increases expression
increases activity

[arsenite co-treated with Curcumin] results in increased expression of CAT protein; Curcumin inhibits the reaction [Cisplatin results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Hydrogen Peroxide results in decreased expression of CAT mRNA]; Curcumin inhibits the reaction [Hypochlorous Acid results in increased activity of CAT protein]; Curcumin inhibits the reaction [Oxaliplatin results in decreased activity of CAT protein]; Curcumin inhibits the reaction [quinocetone results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Vehicle Emissions promotes the reaction [Cisplatin results in decreased activity of CAT protein]]; Curcumin inhibits the reaction [Vehicle Emissions results in decreased activity of CAT protein]
Curcumin results in increased expression of CAT protein
Curcumin results in increased activity of CAT protein
Curcumin inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Acetaminophen results in decreased expression of CAT protein]; Curcumin inhibits the reaction [Acrylamide results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Aflatoxin B1 results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Aflatoxin B1 results in decreased expression of CAT mRNA]; Curcumin inhibits the reaction [Chloranil results in decreased activity of CAT protein]; Curcumin inhibits the reaction [deoxynivalenol results in decreased expression of CAT mRNA]; Curcumin inhibits the reaction [Paraquat results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Rotenone results in decreased activity of CAT protein]; Curcumin inhibits the reaction [sodium arsenite results in decreased activity of CAT protein]; Curcumin inhibits the reaction [sodium arsenite results in decreased expression of CAT mRNA]; Curcumin inhibits the reaction [sodium arsenite results in decreased expression of CAT]; Curcumin metabolite inhibits the reaction [Acetaminophen results in decreased expression of CAT protein]; sodium arsenite inhibits the reaction [Curcumin results in increased activity of CAT protein]
Curcumin results in increased expression of CAT mRNA
[Curcumin co-treated with Chitosan analog] inhibits the reaction [Arsenic results in decreased activity of CAT protein]; [Curcumin co-treated with Vitamin E] inhibits the reaction [Thyroxine results in decreased expression of CAT mRNA]; [Vitamin E co-treated with Curcumin] inhibits the reaction [Thyroxine results in decreased activity of CAT protein]; Curcumin analog inhibits the reaction [APP protein modified form results in decreased activity of CAT protein]; Curcumin analog inhibits the reaction [Monocrotaline results in increased activity of CAT protein]; Curcumin analog inhibits the reaction [sodium arsenite results in decreased activity of CAT protein]; Curcumin inhibits the reaction [[Copper Sulfate results in increased abundance of Copper] which results in decreased activity of CAT protein]; Curcumin inhibits the reaction [[Lipopolysaccharides co-treated with Tobacco Smoke Pollution] results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Acetaminophen results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Acrylonitrile results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Aflatoxin B1 results in decreased activity of CAT protein]; Curcumin inhibits the reaction [APP protein modified form results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Arsenic results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Chloroquine results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Colistin results in decreased expression of CAT protein]; Curcumin inhibits the reaction [Doxorubicin results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Fenitrothion results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Hexachlorocyclohexane results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Indomethacin results in decreased activity of CAT protein]; Curcumin inhibits the reaction [methylmercuric chloride results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Oxygen deficiency results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Paraquat results in decreased activity of CAT protein]; Curcumin inhibits the reaction [sodium arsenite results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Sodium Selenite results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Streptozocin results in decreased expression of CAT protein]; Curcumin inhibits the reaction [Thyroxine results in decreased expression of CAT mRNA]; Curcumin inhibits the reaction [Thyroxine results in decreased expression of CAT protein]

PMID:16770732 PMID:17076682 PMID:17351913 PMID:17461496 PMID:18299980 More...

NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505

G

carbonyl reductase 1

multiple interactions

[[Curcumin binds to and results in decreased activity of CBR1 protein] which results in decreased reduction of Daunorubicin] which results in decreased chemical synthesis of daunorubicinol; [Curcumin binds to and results in decreased activity of CBR1 protein] which results in decreased reduction of Daunorubicin; Curcumin binds to and results in decreased activity of CBR1 protein; Curcumin inhibits the reaction [CBR1 protein results in increased reduction of 2,3-hexanedione]; Curcumin inhibits the reaction [NADP metabolite binds to and results in increased activity of CBR1 protein]

NCBI chr16:93,404,752...93,407,226
Ensembl chr16:93,402,741...93,407,393

G

cell division cycle and apoptosis regulator 1

increases expression

Curcumin results in increased expression of CCAR1 protein

NCBI chr10:62,579,707...62,628,147
Ensembl chr10:62,579,707...62,628,065

G

coiled-coil domain containing 116

increases expression

Curcumin results in increased expression of CCDC116 mRNA

NCBI chr16:16,956,928...16,965,459
Ensembl chr16:16,956,928...16,965,093

G

C-C motif chemokine ligand 2

multiple interactions
decreases expression
increases expression

Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of CCL2 protein]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of CCL2 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of CCL2 protein]; MIR125A mRNA inhibits the reaction [Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of CCL2 protein]]; SIRT6 protein promotes the reaction [Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of CCL2 protein]]
Curcumin results in decreased expression of CCL2 mRNA
Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of CCL2 mRNA]
Curcumin results in decreased expression of CCL2 mRNA; Curcumin results in decreased expression of CCL2 protein
Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 mRNA]
Curcumin results in increased expression of CCL2 mRNA

PMID:10925121 PMID:11053056 PMID:17198877 PMID:17666914 PMID:18403477 More...

NCBI chr11:81,926,403...81,928,278
Ensembl chr11:81,926,397...81,928,279

G

cellular communication network factor 2

decreases expression
multiple interactions

Curcumin results in decreased expression of CCN2 mRNA; Curcumin results in decreased expression of CCN2 protein
IKBKB protein inhibits the reaction [Curcumin results in decreased expression of CCN2 mRNA]; Lipopolysaccharides inhibits the reaction [Curcumin results in decreased expression of CCN2 mRNA]; NFKBIA protein inhibits the reaction [Curcumin results in decreased expression of CCN2 mRNA]; PPARG protein promotes the reaction [Curcumin results in decreased expression of CCN2 mRNA]

PMID:17965732 PMID:19764552

NCBI chr10:24,471,340...24,474,581
Ensembl chr10:24,471,340...24,474,581

G

cyclin A2

multiple interactions
decreases expression

Curcumin inhibits the reaction [bisphenol A results in increased expression of CCNA2 protein]
Curcumin results in decreased expression of CCNA2 protein

NCBI chr 3:36,619,014...36,627,187
Ensembl chr 3:36,619,014...36,626,299

G

cyclin B1

decreases expression

Curcumin results in decreased expression of CCNB1 mRNA; Curcumin results in decreased expression of CCNB1 protein

PMID:17148446 PMID:18719366 PMID:19401701

NCBI chr13:100,915,247...100,922,994
Ensembl chr13:100,915,158...100,923,078

G

cyclin D1

multiple interactions
increases expression
decreases expression
increases degradation

[Curcumin co-treated with Isoflavones] results in decreased expression of CCND1 protein; calyculin A inhibits the reaction [Curcumin results in decreased expression of CCND1 protein]; Curcumin inhibits the reaction [Acrylamide results in increased expression of CCND1 protein]; Curcumin inhibits the reaction [Furazolidone results in increased expression of CCND1 protein]; Curcumin inhibits the reaction [Nicotine results in increased expression of CCND1 protein]; Curcumin inhibits the reaction [Paclitaxel results in increased expression of CCND1 protein]; Curcumin inhibits the reaction [Sirolimus results in increased expression of CCND1 protein]; Curcumin inhibits the reaction [TNF protein results in increased expression of CCND1 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of CCND1 protein]; Curcumin inhibits the reaction [Trichloroethylene results in increased expression of CCND1 protein]; Curcumin inhibits the reaction [VIP protein results in increased expression of CCND1 protein]; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased expression of CCND1 protein]]; lactacystin inhibits the reaction [Curcumin results in increased degradation of CCND1 protein]; piperine inhibits the reaction [Curcumin results in decreased expression of CCND1 protein]; TNFSF10 protein promotes the reaction [Curcumin results in decreased expression of CCND1 protein]; Vitamin E inhibits the reaction [Curcumin results in decreased expression of CCND1 protein]
Curcumin results in increased expression of CCND1 mRNA
Curcumin results in decreased expression of CCND1 mRNA; Curcumin results in decreased expression of CCND1 protein
2-chloro-5-nitrobenzanilide inhibits the reaction [Curcumin results in decreased expression of CCND1 mRNA]; Buthionine Sulfoximine inhibits the reaction [Curcumin results in decreased expression of CCND1 protein]; Curcumin inhibits the reaction [bisphenol A results in decreased expression of CCND1 mRNA]
Curcumin results in decreased expression of CCND1; Curcumin results in decreased expression of CCND1 protein
[Curcumin co-treated with Gemcitabine] results in decreased expression of CCND1 protein
Curcumin analog results in decreased expression of CCND1 protein; Curcumin results in decreased expression of CCND1 mRNA; Curcumin results in decreased expression of CCND1 protein

PMID:15486348 PMID:15489888 PMID:15738001 PMID:16023083 PMID:16219905 More...

NCBI chr 7:144,483,668...144,493,568
Ensembl chr 7:144,483,668...144,493,662

G

cyclin D3

multiple interactions
decreases expression

Curcumin inhibits the reaction [bisphenol A results in increased expression of CCND3 protein]
Curcumin results in decreased expression of CCND3 protein

NCBI chr17:47,815,976...47,910,614
Ensembl chr17:47,815,976...47,910,616

G

cyclin E1

decreases expression
multiple interactions
increases degradation

Curcumin results in decreased expression of CCNE1 protein
Curcumin results in decreased expression of CCNE1 mRNA
Curcumin inhibits the reaction [4,6-dimorpholino-N-(4-nitrophenyl)-1,3,5-triazin-2-amine results in increased expression of CCNE1 protein]; Curcumin inhibits the reaction [Sirolimus results in increased expression of CCNE1 protein]; lactacystin inhibits the reaction [Curcumin results in increased degradation of CCNE1 protein]

PMID:17148446 PMID:18156803 PMID:18299980 PMID:36640941

NCBI chr 7:37,797,409...37,806,915
Ensembl chr 7:37,797,409...37,806,959

G

cell cycle progression 1

increases expression

Curcumin results in increased expression of CCPG1 mRNA

NCBI chr 9:72,892,692...72,923,622
Ensembl chr 9:72,892,711...72,923,622

G

C-C motif chemokine receptor 2

decreases expression

Curcumin results in decreased expression of CCR2 mRNA

NCBI chr 9:123,901,954...123,913,594
Ensembl chr 9:123,901,987...123,913,594

G

CD14 antigen

multiple interactions

Curcumin inhibits the reaction [Glucose promotes the reaction [Lipopolysaccharides results in increased expression of CD14 protein]]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of CD14 protein]

NCBI chr18:36,858,117...36,859,868
Ensembl chr18:36,858,120...36,859,851

G

CD36 molecule

decreases expression
increases expression
multiple interactions

Curcumin results in decreased expression of CD36 mRNA
Curcumin results in increased expression of CD36 mRNA
Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of CD36 mRNA]; Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CD36 mRNA]; Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CD36 protein]
Curcumin results in decreased expression of CD36 mRNA; Curcumin results in decreased expression of CD36 protein

PMID:16713233 PMID:23386263 PMID:23603106

NCBI chr 5:17,986,680...18,093,828
Ensembl chr 5:17,986,688...18,093,799

G

CD40 antigen

decreases expression
multiple interactions

Curcumin results in decreased expression of CD40 mRNA
CD40 protein affects the reaction [Curcumin affects the reaction [Lipopolysaccharides affects the expression of IL10 protein]]; CD40 protein affects the reaction [Curcumin affects the reaction [Lipopolysaccharides affects the expression of IL6 protein]]; CD40 protein affects the reaction [Curcumin affects the reaction [Lipopolysaccharides affects the expression of TNF protein]]; CD40 protein affects the reaction [Curcumin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein]]; CD40 protein affects the reaction [Curcumin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of RELA protein]]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of CD40 protein]
[arsenic trioxide co-treated with Curcumin] results in increased expression of CD40 protein

PMID:16101141 PMID:27430728 PMID:35549587

NCBI chr 2:164,897,535...164,913,574
Ensembl chr 2:164,897,547...164,914,868

G

CD40 ligand

multiple interactions

[arsenic trioxide co-treated with Curcumin] results in increased expression of CD40LG protein

NCBI chr X:56,257,448...56,269,402
Ensembl chr X:56,257,503...56,269,402

G

CD44 antigen

increases expression

Curcumin results in increased expression of CD44 mRNA

NCBI chr 2:102,641,486...102,732,014
Ensembl chr 2:102,641,486...102,732,010

G

CD47 antigen (Rh-related antigen, integrin-associated signal transducer)

multiple interactions

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of CD47 mRNA]

NCBI chr16:49,671,691...49,732,799
Ensembl chr16:49,620,896...49,735,373

G

CD55 molecule, decay accelerating factor for complement

decreases expression

Curcumin results in decreased expression of CD55 mRNA

NCBI chr 1:130,357,526...130,390,513
Ensembl chr 1:130,366,764...130,390,481

G

CDC14 cell division cycle 14B

increases expression

Curcumin results in increased expression of CDC14B mRNA

NCBI chr13:64,337,085...64,423,670
Ensembl chr13:64,337,082...64,423,104

G

cell division cycle 20

decreases expression

Curcumin results in decreased expression of CDC20 mRNA

NCBI chr 4:118,290,098...118,294,540
Ensembl chr 4:118,290,098...118,294,549

G

cell division cycle 25C

increases phosphorylation

Curcumin results in increased phosphorylation of CDC25C protein

NCBI chr18:34,866,046...34,884,644
Ensembl chr18:34,866,046...34,884,586

G

cadherin 1

increases expression
multiple interactions

Curcumin results in increased expression of CDH1 protein
Curcumin inhibits the reaction [Tobacco Smoke Pollution results in decreased expression of CDH1 mRNA]; Curcumin inhibits the reaction [Tobacco Smoke Pollution results in decreased expression of CDH1 protein]
[Curcumin co-treated with Arsenic Trioxide] results in increased expression of CDH1 mRNA; Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased expression of CDH1 protein]; Curcumin inhibits the reaction [Trichloroethylene results in decreased expression of CDH1 protein]

PMID:19573523 PMID:25656647 PMID:26191140 PMID:34233590 PMID:35487055 More...

NCBI chr 8:107,329,982...107,396,879
Ensembl chr 8:107,329,983...107,396,878

G

cadherin 11

decreases expression

Curcumin results in decreased expression of CDH11 protein

NCBI chr 8:103,358,727...103,512,125
Ensembl chr 8:103,358,727...103,512,274

G

cadherin 17

decreases expression

Curcumin results in decreased expression of CDH17 mRNA

NCBI chr 4:11,758,157...11,817,905
Ensembl chr 4:11,758,147...11,817,895

G

cadherin 2

multiple interactions

Curcumin inhibits the reaction [Tobacco Smoke Pollution results in increased expression of CDH2 mRNA]; Curcumin inhibits the reaction [Tobacco Smoke Pollution results in increased expression of CDH2 protein]
Curcumin inhibits the reaction [Trichloroethylene results in increased expression of CDH2 protein]
Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of CDH2 protein]; ICAM1 protein affects the reaction [Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of CDH2 protein]]

PMID:26191140 PMID:34233590 PMID:35549587

NCBI chr18:16,721,934...16,942,303
Ensembl chr18:16,721,934...16,942,303

G

cyclin dependent kinase 1

decreases expression

Curcumin results in decreased expression of CDK1 mRNA
Curcumin results in decreased expression of CDK1 mRNA; Curcumin results in decreased expression of CDK1 protein

PMID:17148446 PMID:18299980 PMID:19401701 PMID:22258452

NCBI chr10:69,170,976...69,188,742
Ensembl chr10:69,170,976...69,188,768

G

cyclin dependent kinase 2

decreases expression
multiple interactions

Curcumin analog results in decreased expression of CDK2 mRNA; Curcumin results in decreased expression of CDK2 protein
Curcumin inhibits the reaction [bisphenol A results in increased expression of CDK2 protein]

PMID:19501152 PMID:23222814 PMID:26409325

NCBI chr10:128,533,807...128,540,920
Ensembl chr10:128,533,808...128,540,900

G

cyclin dependent kinase 4

decreases expression

Curcumin analog results in decreased expression of CDK4 mRNA; Curcumin results in decreased expression of CDK4 protein

PMID:18156803 PMID:24211270 PMID:26409325

NCBI chr10:126,899,404...126,903,157
Ensembl chr10:126,899,403...126,903,789

G

cyclin dependent kinase 5

decreases expression

Curcumin analog results in decreased expression of CDK5 mRNA

NCBI chr 5:24,612,595...24,628,737
Ensembl chr 5:24,623,239...24,628,528

G

cyclin dependent kinase 6

decreases expression

Curcumin results in decreased expression of CDK6 protein

NCBI chr 5:3,391,004...3,581,008
Ensembl chr 5:3,391,485...3,581,008

G

cyclin dependent kinase 7

decreases expression

Curcumin analog results in decreased expression of CDK7 mRNA

NCBI chr13:100,833,532...100,867,454
Ensembl chr13:100,839,139...100,867,447

G

cyclin dependent kinase 9

decreases expression

Curcumin analog results in decreased expression of CDK9 mRNA

NCBI chr 2:32,595,794...32,608,098
Ensembl chr 2:32,595,796...32,603,088

G

cyclin dependent kinase inhibitor 1A

multiple interactions
increases expression
decreases expression

[Arsenic Trioxide co-treated with Curcumin] results in increased expression of CDKN1A protein; [bicalutamide co-treated with Curcumin co-treated with Quercetin] results in increased expression of CDKN1A protein; [Curcumin binds to and results in increased activity of VDR protein] which results in increased expression of CDKN1A mRNA; [Curcumin co-treated with Quercetin] results in increased expression of CDKN1A protein; [piperine co-treated with Curcumin] results in decreased expression of CDKN1A protein; AR protein affects the reaction [[Curcumin co-treated with Quercetin] results in increased expression of CDKN1A protein]; Curcumin inhibits the reaction [bisphenol A results in decreased expression of CDKN1A protein]; Dihydrotestosterone inhibits the reaction [[Curcumin co-treated with Quercetin] results in increased expression of CDKN1A protein]; EGR1 protein affects the reaction [Curcumin results in increased expression of CDKN1A protein]; EGR1 protein promotes the reaction [Curcumin results in increased expression of CDKN1A mRNA]; MAPK1 protein affects the reaction [Curcumin results in increased expression of CDKN1A mRNA]; MAPK8 protein affects the reaction [Curcumin results in increased expression of CDKN1A mRNA]; TNFSF10 protein promotes the reaction [Curcumin results in increased expression of CDKN1A protein]; Vitamin E inhibits the reaction [Curcumin results in decreased expression of CDKN1A protein]
[Curcumin co-treated with Quercetin] inhibits the reaction [Benzo(a)pyrene results in decreased expression of CDKN1A protein]; Curcumin inhibits the reaction [Benzo(a)pyrene results in decreased expression of CDKN1A protein]
Curcumin results in increased expression of CDKN1A; Curcumin results in increased expression of CDKN1A mRNA; Curcumin results in increased expression of CDKN1A protein
[Curcumin results in decreased expression of MDM2 protein] which results in decreased expression of CDKN1A mRNA; Curcumin results in decreased expression of CDKN1A protein
Buthionine Sulfoximine inhibits the reaction [Curcumin results in increased expression of CDKN1A protein]

PMID:15713895 PMID:15738001 PMID:17148446 PMID:17332326 PMID:17602960 More...

NCBI chr17:29,309,953...29,319,696
Ensembl chr17:29,309,950...29,319,701

G

cyclin dependent kinase inhibitor 1B

increases expression
multiple interactions
decreases expression

Curcumin results in increased expression of CDKN1B mRNA; Curcumin results in increased expression of CDKN1B protein
Buthionine Sulfoximine inhibits the reaction [Curcumin results in increased expression of CDKN1B protein]
[Arsenic Trioxide co-treated with Curcumin] results in increased expression of CDKN1B protein; [Curcumin co-treated with Arsenic Trioxide] results in increased expression of CDKN1B protein; [Curcumin co-treated with Quercetin] results in increased expression of CDKN1B protein; AR protein affects the reaction [[Curcumin co-treated with Quercetin] results in increased expression of CDKN1B protein]; Dihydrotestosterone inhibits the reaction [[Curcumin co-treated with Quercetin] results in increased expression of CDKN1B protein]; TNFSF10 protein promotes the reaction [Curcumin results in increased expression of CDKN1B protein]
Curcumin results in decreased expression of CDKN1B protein

PMID:15713895 PMID:17602960 PMID:18156803 PMID:18226269 PMID:18593936 More...

NCBI chr 6:134,897,364...134,902,488
Ensembl chr 6:134,897,364...134,902,476

G

cyclin dependent kinase inhibitor 2A

decreases expression
increases expression

Curcumin results in decreased expression of CDKN2A protein
Curcumin results in increased expression of CDKN2A protein

PMID:17148446 PMID:18156803

NCBI chr 4:89,192,710...89,212,856
Ensembl chr 4:89,192,708...89,212,890

G

cyclin dependent kinase inhibitor 2D

decreases expression

Curcumin results in decreased expression of CDKN2D mRNA

NCBI chr 9:21,199,759...21,202,553
Ensembl chr 9:21,199,706...21,202,703

G

caudal type homeobox 2

increases expression

Curcumin results in increased expression of CDX2 mRNA

PMID:18299980 PMID:27237783

NCBI chr 5:147,237,710...147,244,059
Ensembl chr 5:147,237,615...147,244,080

G

CCAAT/enhancer binding protein alpha

multiple interactions

Curcumin inhibits the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of CEBPA mRNA]; Curcumin inhibits the reaction [butylbenzyl phthalate promotes the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of CEBPA mRNA]]; Curcumin inhibits the reaction [Dietary Fats results in increased expression of CEBPA mRNA]

PMID:19297423 PMID:28595985

NCBI chr 7:34,818,718...34,821,353
Ensembl chr 7:34,818,718...34,821,353

G

CCAAT/enhancer binding protein beta

multiple interactions

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of CEBPB mRNA]

NCBI chr 2:167,530,835...167,532,352
Ensembl chr 2:167,530,835...167,532,338

G

carboxylesterase 1D

multiple interactions

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of CES1 mRNA]

NCBI chr 8:93,892,700...93,924,432
Ensembl chr 8:93,892,696...93,924,466

G

carboxylesterase 3B

multiple interactions

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of CES3 mRNA]

NCBI chr 8:105,810,365...105,820,561
Ensembl chr 8:105,810,385...105,820,561

G

CASP8 and FADD-like apoptosis regulator

multiple interactions
decreases expression

Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of CFLAR mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of CFLAR mRNA]
Curcumin results in decreased expression of CFLAR protein

PMID:16173963 PMID:16219905 PMID:23452621

NCBI chr 1:58,750,353...58,798,043
Ensembl chr 1:58,750,667...58,798,043

G

cystic fibrosis transmembrane conductance regulator

multiple interactions
increases activity
affects localization

[PRKCA protein results in increased phosphorylation of CFTR protein] promotes the reaction [Curcumin results in increased activity of CFTR protein]; Adenosine Triphosphate affects the reaction [Curcumin results in increased activity of CFTR protein mutant form]; Curcumin analog inhibits the reaction [CFTR protein results in increased export of Hyaluronic Acid]
Curcumin results in increased activity of CFTR protein; Curcumin results in increased activity of CFTR protein mutant form
Curcumin affects the localization of CFTR protein mutant form
Curcumin affects the folding of and affects the localization of CFTR protein mutant form

PMID:15105504 PMID:15280357 PMID:15582996 PMID:17178710 PMID:23978416

NCBI chr 6:18,170,686...18,322,769
Ensembl chr 6:18,170,686...18,322,767

G

choline acetyltransferase

multiple interactions

Curcumin inhibits the reaction [sodium arsenite results in decreased expression of CHAT protein]

NCBI chr14:32,130,160...32,187,866
Ensembl chr14:32,130,160...32,187,946

G

checkpoint kinase 1

decreases response to substance
multiple interactions
increases activity
increases phosphorylation

CHEK1 protein results in decreased susceptibility to Curcumin
Curcumin inhibits the reaction [Furazolidone results in increased expression of CHEK1 protein]
Curcumin results in increased activity of CHEK1 protein
Curcumin results in increased phosphorylation of CHEK1 protein

PMID:18602917 PMID:19401701 PMID:27996348

NCBI chr 9:36,619,935...36,637,897
Ensembl chr 9:36,619,778...36,638,361

G

checkpoint kinase 2

multiple interactions
increases phosphorylation

[Curcumin co-treated with Dihydrotestosterone] results in increased phosphorylation of CHEK2 protein; [Curcumin co-treated with Metribolone] results in increased phosphorylation of CHEK2 protein; [Isoflavones co-treated with Curcumin] results in increased phosphorylation of CHEK2 protein; Flutamide inhibits the reaction [[Dihydrotestosterone co-treated with Curcumin] results in increased phosphorylation of CHEK2 protein]
Curcumin results in increased phosphorylation of CHEK2 protein

NCBI chr 5:110,987,668...111,022,006
Ensembl chr 5:110,987,845...111,022,011

G

chitinase-like 3

multiple interactions

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of CHIL3 mRNA]

NCBI chr 3:106,054,870...106,074,852
Ensembl chr 3:106,054,870...106,074,880

G

cholinergic receptor, muscarinic 2, cardiac

multiple interactions

Curcumin inhibits the reaction [sodium arsenite results in decreased expression of CHRM2 mRNA]

NCBI chr 6:36,364,928...36,505,573
Ensembl chr 6:36,365,019...36,505,349

G

conserved helix-loop-helix ubiquitous kinase

multiple interactions
decreases activity

Curcumin inhibits the reaction [TNF protein results in increased activity of CHUK protein]; Curcumin inhibits the reaction [TNFSF11 protein results in increased activity of CHUK protein]
Curcumin results in decreased activity of CHUK protein

PMID:15129424 PMID:15489888 PMID:16023083 PMID:16219905

NCBI chr19:44,061,773...44,095,940
Ensembl chr19:44,061,774...44,095,919

G

creatine kinase, brain

multiple interactions

Curcumin inhibits the reaction [Doxorubicin results in increased expression of [CKM protein binds to CKB protein]]; Curcumin inhibits the reaction [lead acetate results in increased secretion of [CKM protein binds to CKB protein]]

PMID:21378372 PMID:29315967

NCBI chr12:111,635,789...111,638,772
Ensembl chr12:111,635,795...111,638,772

G

creatine kinase, muscle

multiple interactions

Curcumin inhibits the reaction [Doxorubicin results in increased expression of [CKM protein binds to CKB protein]]; Curcumin inhibits the reaction [lead acetate results in increased secretion of [CKM protein binds to CKB protein]]

PMID:21378372 PMID:29315967

NCBI chr 7:19,145,019...19,155,508
Ensembl chr 7:19,138,701...19,156,766

G

chloride channel accessory 4A

multiple interactions

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of CLCA4A mRNA]

NCBI chr 3:144,658,247...144,680,806
Ensembl chr 3:144,658,241...144,680,806

G

chloride channel, voltage-sensitive 6

decreases expression

Curcumin results in decreased expression of CLCN6 mRNA

NCBI chr 4:148,088,716...148,123,270
Ensembl chr 4:148,088,716...148,123,278

G

claudin 1

multiple interactions

Curcumin inhibits the reaction [deoxynivalenol results in decreased expression of CLDN1 mRNA]; Curcumin inhibits the reaction [deoxynivalenol results in decreased expression of CLDN1 protein]

NCBI chr16:26,175,395...26,190,589
Ensembl chr16:26,175,392...26,190,591

G

claudin 2

multiple interactions

Curcumin inhibits the reaction [maleic acid results in decreased expression of CLDN2]

NCBI chr X:138,701,552...138,712,135
Ensembl chr X:138,701,577...138,712,135

G

collagen, type I, alpha 1

multiple interactions
decreases expression

Buthionine Sulfoximine inhibits the reaction [Curcumin results in decreased expression of COL1A1 mRNA]; Buthionine Sulfoximine inhibits the reaction [Curcumin results in decreased expression of COL1A1 protein]; Curcumin analog inhibits the reaction [Glucose results in increased expression of COL1A1 mRNA]; Curcumin inhibits the reaction [Bleomycin results in increased expression of COL1A1 mRNA]; Curcumin inhibits the reaction [Bleomycin results in increased expression of COL1A1 protein]; Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of COL1A1 mRNA]; Curcumin inhibits the reaction [Glucose results in increased expression of COL1A1 mRNA]; Curcumin inhibits the reaction [Thioacetamide results in increased expression of COL1A1 mRNA]; pomegranate fruit rind promotes the reaction [Curcumin inhibits the reaction [Thioacetamide results in increased expression of COL1A1 mRNA]]
Curcumin analog inhibits the reaction [Streptozocin results in increased expression of COL1A1 mRNA]; Curcumin inhibits the reaction [Streptozocin results in increased expression of COL1A1 mRNA]
Curcumin results in decreased expression of COL1A1 mRNA; Curcumin results in decreased expression of COL1A1 protein

PMID:17355460 PMID:17434272 PMID:17531121 PMID:17602960 PMID:17965732 More...

NCBI chr11:94,827,050...94,843,868
Ensembl chr11:94,827,050...94,843,868

G

collagen, type I, alpha 2

multiple interactions

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of COL1A2 mRNA]

NCBI chr 6:4,505,618...4,541,543
Ensembl chr 6:4,504,814...4,541,544

G

collagen, type XXVII, alpha 1

increases expression

Curcumin results in increased expression of COL27A1 mRNA

NCBI chr 4:63,132,246...63,253,228
Ensembl chr 4:63,132,241...63,253,228

G

collagen, type II, alpha 1

increases expression
multiple interactions

Curcumin results in increased expression of COL2A1 mRNA; Curcumin results in increased expression of COL2A1 protein
[resveratrol co-treated with Curcumin] results in increased expression of COL2A1 protein

PMID:18321735 PMID:19889203

NCBI chr15:97,873,483...97,902,525
Ensembl chr15:97,873,483...97,902,576

G

collagen, type III, alpha 1

multiple interactions

Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of COL3A1 mRNA]

NCBI chr 1:45,350,698...45,388,866
Ensembl chr 1:45,350,698...45,388,866

G

collagen, type IV, alpha 1

increases expression
multiple interactions

Curcumin results in increased expression of COL4A1 mRNA
Curcumin analog inhibits the reaction [Glucose results in increased expression of COL4A1 mRNA]; Curcumin inhibits the reaction [Glucose results in increased expression of COL4A1 mRNA]
Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of COL4A1 mRNA]

PMID:18200517 PMID:21594647 PMID:28700904

NCBI chr 8:11,248,423...11,362,889
Ensembl chr 8:11,248,423...11,362,826

G

collagen, type IV, alpha 2

multiple interactions

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of COL4A2 mRNA]

NCBI chr 8:11,362,878...11,499,287
Ensembl chr 8:11,362,805...11,499,287

G

collagen, type IV, alpha 5

decreases expression

Curcumin results in decreased expression of COL4A5 mRNA

NCBI chr X:140,258,367...140,472,232
Ensembl chr X:140,258,381...140,472,230

G

collagen, type V, alpha 1

multiple interactions

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of COL5A1 mRNA]

NCBI chr 2:27,776,393...27,929,522
Ensembl chr 2:27,776,437...27,929,526

G

collagen, type V, alpha 2

multiple interactions

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of COL5A2 mRNA]

NCBI chr 1:45,413,491...45,542,442
Ensembl chr 1:45,413,481...45,542,442

G

carnitine palmitoyltransferase 1a, liver

increases expression

Curcumin results in increased expression of CPT1A mRNA

NCBI chr19:3,372,328...3,435,735
Ensembl chr19:3,372,334...3,435,733

G

cAMP responsive element binding protein 1

increases expression
multiple interactions
increases phosphorylation

Curcumin results in increased expression of CREB1 mRNA
1,3-dihydro-1-(1-((4-(6-phenyl-1H-imidazo(4,5-g)quinoxalin-7-yl)phenyl)methyl)-4-piperidinyl)-2H-benzimidazol-2-one inhibits the reaction [Curcumin inhibits the reaction [sodium arsenite results in decreased phosphorylation of CREB1 protein]]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Curcumin inhibits the reaction [sodium arsenite results in decreased phosphorylation of CREB1 protein]]; Curcumin inhibits the reaction [sodium arsenite results in decreased phosphorylation of CREB1 protein]
[Docosahexaenoic Acids co-treated with Curcumin] results in increased expression of CREB1 mRNA; Curcumin inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of CREB1 protein]
Curcumin results in increased phosphorylation of CREB1 protein

PMID:17022948 PMID:18299980 PMID:22911773 PMID:27966075 PMID:29723552 More...

NCBI chr 1:64,571,963...64,643,707
Ensembl chr 1:64,571,804...64,643,707

G

cAMP responsive element binding protein 3

increases expression

Curcumin results in increased expression of CREB3 mRNA

NCBI chr 4:43,562,658...43,567,061
Ensembl chr 4:43,562,332...43,567,060

G

CREB binding protein

multiple interactions

Curcumin inhibits the reaction [Dihydrotestosterone promotes the reaction [CREBBP protein binds to KLK3 enhancer]]

NCBI chr16:3,899,198...4,031,864
Ensembl chr16:3,899,192...4,031,861

G

C-reactive protein, pentraxin-related

multiple interactions

Curcumin analog inhibits the reaction [Copper Sulfate results in increased secretion of CRP protein]; Curcumin inhibits the reaction [Copper Sulfate results in increased secretion of CRP protein]; Curcumin inhibits the reaction [Fructose results in increased expression of CRP protein]; Curcumin inhibits the reaction [lead acetate results in increased secretion of CRP protein]
[Curcumin co-treated with Niacin co-treated with ZM 241385] inhibits the reaction [Rotenone results in increased expression of CRP protein]; Curcumin inhibits the reaction [Rotenone results in increased expression of CRP protein]

PMID:21378372 PMID:26713546 PMID:30431687 PMID:31820278

NCBI chr 1:172,525,623...172,527,533
Ensembl chr 1:172,525,622...172,660,598

G

crystallin, alpha B

multiple interactions

Curcumin promotes the reaction [arsenite results in increased expression of CRYAB protein]
[Curcumin co-treated with arsenite] results in increased expression of CRYAB mRNA; [Curcumin co-treated with Cadmium Chloride] results in increased expression of CRYAB protein; Curcumin promotes the reaction [arsenite results in increased expression of CRYAB protein]

NCBI chr 9:50,657,251...50,667,936
Ensembl chr 9:50,662,625...50,667,936

G

citrate synthase

affects expression

Curcumin affects the expression of CS mRNA

NCBI chr10:128,173,596...128,198,351
Ensembl chr10:128,173,603...128,198,348

G

colony stimulating factor 1 (macrophage)

multiple interactions

Curcumin inhibits the reaction [CSF1 protein results in increased phosphorylation of CSF1R protein]

NCBI chr 3:107,648,364...107,668,048
Ensembl chr 3:107,648,364...107,667,785

G

colony stimulating factor 1 receptor

multiple interactions
increases expression

Curcumin inhibits the reaction [CSF1 protein results in increased phosphorylation of CSF1R protein]
Curcumin results in increased expression of CSF1R mRNA

PMID:15129424 PMID:22714040

NCBI chr18:61,238,644...61,264,211
Ensembl chr18:61,233,670...61,265,221

G

colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)

increases expression

Curcumin results in increased expression of CSF2RA mRNA

NCBI chr19:61,205,629...61,221,141
Ensembl chr19:61,212,395...61,216,867

G

colony stimulating factor 2 receptor, beta 2, low-affinity (granulocyte-macrophage)

multiple interactions

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of CSF2RB mRNA]

NCBI chr15:78,166,707...78,189,921
Ensembl chr15:78,166,707...78,189,921

G

component of Sp100-rs

decreases expression

Curcumin results in decreased expression of CSPRS mRNA

G

cytotoxic T lymphocyte-associated protein 2 alpha

multiple interactions

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of CTLA2A mRNA]

NCBI chr13:61,081,969...61,084,439
Ensembl chr13:61,081,969...61,084,439

G

catenin beta 1

decreases expression
increases expression
multiple interactions
decreases phosphorylation
increases degradation

Curcumin analog results in decreased expression of CTNNB1 mRNA; Curcumin results in decreased expression of CTNNB1 mRNA; Curcumin results in decreased expression of CTNNB1 protein
Curcumin results in increased expression of CTNNB1 mRNA
Curcumin inhibits the reaction [bisphenol A results in decreased expression of CTNNB1 mRNA]; Curcumin results in decreased phosphorylation of and affects the localization of CTNNB1 protein
Curcumin results in decreased phosphorylation of CTNNB1 protein
[piperine co-treated with Curcumin] results in decreased expression of CTNNB1 protein; Curcumin inhibits the reaction [CTNNB1 protein binds to TCF7L2 protein]; Curcumin inhibits the reaction [IL1B protein results in increased expression of CTNNB1 protein]; Curcumin results in decreased activity of [CTNNB1 protein binds to TCF7L2 protein]; Vitamin E inhibits the reaction [Curcumin results in decreased expression of CTNNB1 protein]
Curcumin analog results in increased degradation of CTNNB1 protein; Curcumin results in increased degradation of CTNNB1 protein

PMID:10783313 PMID:17041101 PMID:19294764 PMID:19573523 PMID:25963729 More...

NCBI chr 9:120,762,466...120,789,573
Ensembl chr 9:120,758,282...120,789,573

G

cathepsin B

multiple interactions
decreases expression

Curcumin inhibits the reaction [Isoproterenol results in increased activity of CTSB protein]
Curcumin analog results in decreased expression of CTSB mRNA

PMID:8534267 PMID:26409325

NCBI chr14:63,359,911...63,383,372
Ensembl chr14:63,359,911...63,383,372

G

cathepsin D

multiple interactions
decreases expression

Curcumin inhibits the reaction [Isoproterenol results in decreased activity of CTSD protein]; Curcumin inhibits the reaction [Isoproterenol results in increased activity of CTSD protein]
Curcumin analog results in decreased expression of CTSD mRNA

PMID:8534267 PMID:26409325

NCBI chr 7:141,929,647...141,941,564
Ensembl chr 7:141,929,648...141,941,775

G

cathepsin L

decreases expression

Curcumin results in decreased expression of CTSL protein

NCBI chr13:64,509,704...64,518,586
Ensembl chr13:64,507,151...64,518,704

G

cathepsin S

decreases expression

Curcumin results in decreased expression of CTSS mRNA

NCBI chr 3:95,434,097...95,463,716
Ensembl chr 3:95,434,097...95,463,714

G

C-X-C motif chemokine ligand 1

multiple interactions
decreases expression

NFKBIA protein affects the reaction [Curcumin results in decreased expression of CXCL1 mRNA]
Curcumin results in decreased expression of CXCL1 mRNA; Curcumin results in decreased expression of CXCL1 protein

NCBI chr 5:91,039,104...91,040,980
Ensembl chr 5:91,039,100...91,040,974

G

C-X-C motif chemokine ligand 12

multiple interactions

Curcumin inhibits the reaction [CXCL12 protein results in increased expression of CXCR4 mRNA]; Curcumin inhibits the reaction [CXCL12 protein results in increased phosphorylation of AKT1 protein]; Curcumin inhibits the reaction [CXCL12 protein results in increased phosphorylation of NOS3 protein]

NCBI chr 6:117,145,496...117,158,329
Ensembl chr 6:117,145,496...117,158,328

G

C-X-C motif chemokine ligand 14

decreases expression

Curcumin results in decreased expression of CXCL14 mRNA

NCBI chr13:56,436,456...56,444,624
Ensembl chr13:56,436,456...56,444,364

G

C-X-C motif chemokine ligand 15

decreases expression
multiple interactions

Curcumin results in decreased expression of CXCL8 protein
Curcumin inhibits the reaction [[TNF protein co-treated with IL1B protein] results in increased expression of CXCL8 mRNA]; Curcumin inhibits the reaction [Acetylmuramyl-Alanyl-Isoglutamine results in increased expression of and results in increased secretion of CXCL8 protein]; Curcumin inhibits the reaction [Acids results in increased expression of CXCL8 mRNA]; Curcumin inhibits the reaction [Acids results in increased secretion of CXCL8 protein]; Curcumin inhibits the reaction [cadmium sulfate results in increased expression of CXCL8 mRNA]; Curcumin inhibits the reaction [cadmium sulfate results in increased secretion of CXCL8 protein]; Curcumin inhibits the reaction [IL1B protein results in increased expression of CXCL8 mRNA]; Curcumin inhibits the reaction [lauric acid results in increased expression of and results in increased secretion of CXCL8 protein]; Curcumin inhibits the reaction [Neurotensin results in increased expression of CXCL8 mRNA]; Curcumin inhibits the reaction [Neurotensin results in increased expression of CXCL8 protein]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of CXCL8 mRNA]; Curcumin inhibits the reaction [Shiga Toxin results in increased expression of CXCL8 protein]; Curcumin inhibits the reaction [Sodium Fluoride results in increased secretion of CXCL8 protein]; Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of CXCL8 protein]; Curcumin inhibits the reaction [TNF protein results in decreased expression of CXCL8 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of CXCL8 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of CXCL8 protein]; Curcumin results in decreased expression of and results in decreased secretion of CXCL8 protein; TNFSF10 protein promotes the reaction [Curcumin results in decreased expression of CXCL8 protein]

PMID:12216086 PMID:16819191 PMID:17000667 PMID:17151092 PMID:17273796 More...

NCBI chr 5:90,942,393...90,950,926
Ensembl chr 5:90,942,393...90,950,926

G

C-X-C motif chemokine ligand 2

decreases expression
multiple interactions

Curcumin results in decreased expression of CXCL2 mRNA; Curcumin results in decreased expression of CXCL2 protein
Curcumin inhibits the reaction [Fluorouracil results in increased expression of CXCL2 mRNA]; Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of CXCL2 mRNA]
Curcumin inhibits the reaction [[TNF protein co-treated with IL1B protein] results in increased secretion of CXCL2 protein]
NFKBIA protein affects the reaction [Curcumin results in decreased expression of CXCL2 mRNA]

PMID:17999991 PMID:18001810 PMID:18200517 PMID:27194111

NCBI chr 5:91,051,758...91,053,797
Ensembl chr 5:91,051,730...91,053,797

G

C-X-C motif chemokine ligand 3

decreases expression
multiple interactions

Curcumin results in decreased expression of CXCL1 mRNA; Curcumin results in decreased expression of CXCL1 protein
Curcumin inhibits the reaction [Fluorouracil results in increased expression of CXCL1 mRNA]; Curcumin inhibits the reaction [Fluorouracil results in increased expression of CXCL1 protein]
NFKBIA protein affects the reaction [Curcumin results in decreased expression of CXCL1 mRNA]

PMID:17999991 PMID:27194111

NCBI chr 5:90,933,960...90,935,952
Ensembl chr 5:90,933,962...90,937,459

G

C-X-C motif chemokine receptor 1

increases expression

Curcumin results in increased expression of CXCR1 protein

NCBI chr 1:74,228,862...74,233,867
Ensembl chr 1:74,230,944...74,233,790

G

C-X-C motif chemokine receptor 2

increases expression

Curcumin results in increased expression of CXCR2 protein

NCBI chr 1:74,193,153...74,200,405
Ensembl chr 1:74,193,150...74,200,405

G

C-X-C motif chemokine receptor 4

decreases expression
multiple interactions

Curcumin results in decreased expression of CXCR4 mRNA
Curcumin inhibits the reaction [CXCL12 protein results in increased expression of CXCR4 mRNA]

PMID:17198877 PMID:18660423

NCBI chr 1:128,515,936...128,520,036
Ensembl chr 1:128,515,936...128,520,030

G

cytochrome c, somatic

affects localization
multiple interactions

Curcumin affects the localization of CYCS protein
[Arsenic Trioxide co-treated with Curcumin] results in increased expression of CYCS protein; [Curcumin binds to 4-bis(2-chloroethyl)aminobenzaldehyde] which results in increased expression of CYCS protein

PMID:19235267 PMID:27430728 PMID:33617879

NCBI chr 6:50,539,543...50,543,549
Ensembl chr 6:50,539,543...50,543,518

G

cytochrome P450, family 1, subfamily a, polypeptide 1

multiple interactions
increases activity
increases expression
decreases activity
decreases expression

Acetylcysteine affects the reaction [Curcumin affects the reaction [6-formylindolo(3,2-b)carbazole results in increased activity of CYP1A1 protein]]; Buthionine Sulfoximine affects the reaction [Curcumin affects the reaction [6-formylindolo(3,2-b)carbazole results in increased activity of CYP1A1 protein]]; Curcumin affects the reaction [6-formylindolo(3,2-b)carbazole results in increased activity of CYP1A1 protein]; Curcumin affects the reaction [6-formylindolo(3,2-b)carbazole results in increased expression of CYP1A1 mRNA]; Curcumin inhibits the reaction [6-formylindolo(3,2-b)carbazole results in increased activity of CYP1A1 protein]; Curcumin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]; Curcumin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 protein]; Curcumin promotes the reaction [6-formylindolo(3,2-b)carbazole results in increased expression of CYP1A1 mRNA]; decitabine affects the reaction [Curcumin affects the reaction [6-formylindolo(3,2-b)carbazole results in increased expression of CYP1A1 mRNA]]; trichostatin A affects the reaction [Curcumin affects the reaction [6-formylindolo(3,2-b)carbazole results in increased expression of CYP1A1 mRNA]]
Curcumin inhibits the reaction [Aflatoxin B1 results in increased activity of CYP1A1 protein]; Curcumin inhibits the reaction [beta-Naphthoflavone results in increased activity of CYP1A1 protein]; Curcumin inhibits the reaction [Carbon Tetrachloride results in decreased activity of CYP1A1 protein]; Curcumin inhibits the reaction [Fenitrothion results in increased expression of CYP1A1 mRNA]
Curcumin results in increased activity of CYP1A1 protein
Curcumin results in increased expression of CYP1A1 mRNA
Curcumin results in decreased activity of CYP1A1 protein
Curcumin results in decreased expression of CYP1A1 mRNA
Curcumin inhibits the reaction [Benzo(a)pyrene results in increased activity of CYP1A1 protein]; Curcumin inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; Curcumin inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]; Curcumin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]

PMID:11454723 PMID:12628514 PMID:15841493 PMID:16288784 PMID:17012224 More...

NCBI chr 9:57,595,211...57,611,107
Ensembl chr 9:57,595,211...57,611,107

G

cytochrome P450, family 1, subfamily a, polypeptide 2

decreases activity
multiple interactions

Curcumin results in decreased activity of CYP1A2 protein
Curcumin inhibits the reaction [Carbon Tetrachloride results in decreased activity of CYP1A2 protein]; Curcumin inhibits the reaction [Fenitrothion results in increased expression of CYP1A2 mRNA]
Curcumin inhibits the reaction [Aflatoxin B1 results in decreased expression of CYP1A2 mRNA]; Curcumin inhibits the reaction [Benzo(a)pyrene results in increased activity of CYP1A2 protein]; Curcumin inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A2 mRNA]; Curcumin inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A2 protein]

PMID:15841493 PMID:16288784 PMID:18321868 PMID:34802538 PMID:35063475

NCBI chr 9:57,584,220...57,590,938
Ensembl chr 9:57,584,220...57,590,986

G

cytochrome P450, family 1, subfamily b, polypeptide 1

multiple interactions
decreases expression

Curcumin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1B1 mRNA]; Curcumin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1B1 protein]
Curcumin results in decreased expression of CYP1B1 mRNA

PMID:17637178 PMID:19018768

NCBI chr17:80,014,369...80,022,490
Ensembl chr17:80,008,966...80,022,490

G

cytochrome P450, family 24, subfamily a, polypeptide 1

multiple interactions
increases expression

[Curcumin binds to and results in increased activity of VDR protein] which results in increased expression of CYP24A1 mRNA
Curcumin results in increased expression of CYP24A1 protein

NCBI chr 2:170,324,877...170,339,065
Ensembl chr 2:170,324,628...170,339,065

G

cytochrome P450, family 2, subfamily d, polypeptide 22

decreases expression

Curcumin results in decreased expression of CYP2D6 mRNA

NCBI chr15:82,254,728...82,264,461
Ensembl chr15:82,254,728...82,264,461

G

cytochrome P450, family 2, subfamily e, polypeptide 1

affects expression
multiple interactions
increases expression

Curcumin affects the expression of CYP2E1 protein
Curcumin inhibits the reaction [Acetaminophen results in increased expression of CYP2E1 mRNA]
Curcumin inhibits the reaction [Acetaminophen results in increased expression of CYP2E1 mRNA]; Curcumin inhibits the reaction [Acetaminophen results in increased expression of CYP2E1 protein]; Curcumin metabolite inhibits the reaction [Acetaminophen results in increased expression of CYP2E1 mRNA]; Curcumin metabolite inhibits the reaction [Acetaminophen results in increased expression of CYP2E1 protein]; Curcumin metabolite promotes the reaction [Acetaminophen results in decreased activity of CYP2E1 protein]
Curcumin inhibits the reaction [Acrylamide results in increased expression of CYP2E1 protein]
Curcumin results in increased expression of CYP2E1 mRNA

PMID:16805852 PMID:18539377 PMID:24508477 PMID:30423402 PMID:33350580

NCBI chr 7:140,343,732...140,354,903
Ensembl chr 7:140,343,652...140,354,900

G

cytochrome P450, family 3, subfamily a, polypeptide 11

multiple interactions

Curcumin inhibits the reaction [Aflatoxin B1 results in decreased expression of CYP3A11 mRNA]

NCBI chr 5:145,791,417...145,816,664
Ensembl chr 5:145,791,236...145,816,774

G

cytohesin 4

increases expression

Curcumin results in increased expression of CYTH4 mRNA

NCBI chr15:78,481,247...78,506,219
Ensembl chr15:78,481,247...78,506,219

G

Fas death domain-associated protein

increases expression

Curcumin results in increased expression of DAXX mRNA

NCBI chr17:34,128,379...34,134,564
Ensembl chr17:34,128,388...34,134,564

G

drebrin 1

multiple interactions

Curcumin inhibits the reaction [Glucose results in decreased expression of DBN1 mRNA]

NCBI chr13:55,621,241...55,635,874
Ensembl chr13:55,621,242...55,635,924

G

decorin

increases expression

Curcumin results in increased expression of DCN mRNA

NCBI chr10:97,315,362...97,354,025
Ensembl chr10:97,315,471...97,354,005

G

doublecortin

multiple interactions
increases expression

Curcumin inhibits the reaction [bisphenol A results in decreased expression of DCX mRNA]
Curcumin inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of DCX protein]
Curcumin results in increased expression of DCX mRNA

PMID:25963729 PMID:32735850

NCBI chr X:142,638,838...142,716,392
Ensembl chr X:142,638,838...142,716,307

G

DNA-damage inducible transcript 3

multiple interactions
increases expression

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Curcumin results in increased expression of DDIT3 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Curcumin results in increased expression of DDIT3 protein]; Acetylcysteine inhibits the reaction [Curcumin results in increased expression of DDIT3 mRNA]; Buthionine Sulfoximine promotes the reaction [Curcumin results in increased expression of DDIT3 mRNA]; Buthionine Sulfoximine promotes the reaction [Curcumin results in increased expression of DDIT3 protein]; Curcumin inhibits the reaction [Furazolidone results in increased expression of DDIT3 protein]; Glutathione inhibits the reaction [Curcumin results in increased expression of DDIT3 mRNA]; Glutathione inhibits the reaction [Curcumin results in increased expression of DDIT3 protein]; PRKCD protein promotes the reaction [Curcumin results in increased expression of DDIT3 mRNA]; rottlerin inhibits the reaction [Curcumin results in increased expression of DDIT3 mRNA]; Wortmannin inhibits the reaction [Curcumin results in increased expression of DDIT3 mRNA]; Wortmannin inhibits the reaction [Curcumin results in increased expression of DDIT3 protein]
Curcumin results in increased expression of DDIT3 mRNA; Curcumin results in increased expression of DDIT3 protein

PMID:16613838 PMID:17171638 PMID:18200517 PMID:18719366 PMID:21793155 More...

NCBI chr10:127,126,662...127,132,160
Ensembl chr10:127,126,643...127,132,157
Ensembl chr10:127,126,643...127,132,157

G

DNA-damage-inducible transcript 4-like

decreases expression
increases expression

Curcumin results in decreased expression of DDIT4L mRNA
Curcumin results in increased expression of DDIT4L mRNA

PMID:17999991 PMID:18299980

NCBI chr 3:137,329,433...137,334,093
Ensembl chr 3:137,327,373...137,334,094

G

DNA fragmentation factor, beta subunit

increases expression
decreases expression

Curcumin results in increased expression of DFFB mRNA; Curcumin results in increased expression of DFFB protein
Curcumin results in decreased expression of DFFB protein

PMID:21397623 PMID:22714040

NCBI chr 4:154,048,904...154,059,578
Ensembl chr 4:154,048,906...154,059,583

G

24-dehydrocholesterol reductase

decreases expression
affects expression

Curcumin results in decreased expression of DHCR24 mRNA
Curcumin affects the expression of DHCR24 mRNA

NCBI chr 4:106,418,279...106,446,310
Ensembl chr 4:106,418,235...106,446,310

G

7-dehydrocholesterol reductase

affects expression
decreases expression

Curcumin affects the expression of DHCR7 mRNA
Curcumin results in decreased expression of DHCR7 mRNA

NCBI chr 7:143,376,827...143,402,147
Ensembl chr 7:143,376,882...143,402,147

G

dehydrogenase/reductase 1

decreases expression

Curcumin results in decreased expression of DHRS1 mRNA

NCBI chr14:55,976,477...55,983,147
Ensembl chr14:55,976,477...55,983,147

G

diablo, IAP-binding mitochondrial protein

affects localization
multiple interactions
increases expression
increases response to substance

Curcumin affects the localization of DIABLO protein
[arsenic trioxide co-treated with Curcumin] results in increased expression of DIABLO protein
Curcumin results in increased expression of DIABLO mRNA
DIABLO protein results in increased susceptibility to Curcumin

PMID:17277231 PMID:23555722 PMID:27430728

NCBI chr 5:123,649,393...123,664,825
Ensembl chr 5:123,647,828...123,662,239

G

dickkopf WNT signaling pathway inhibitor 1

decreases expression
multiple interactions

Curcumin results in decreased expression of DKK1 mRNA; Curcumin results in decreased expression of DKK1 protein
Curcumin inhibits the reaction [bisphenol A results in increased expression of DKK1 mRNA]; Curcumin inhibits the reaction [bisphenol A results in increased expression of DKK1 protein]

NCBI chr19:30,523,276...30,526,896
Ensembl chr19:30,523,263...30,527,065

G

discs large MAGUK scaffold protein 4

multiple interactions

Curcumin inhibits the reaction [sodium arsenite results in decreased expression of DLG4 protein]

NCBI chr11:69,908,029...69,938,107
Ensembl chr11:69,907,768...69,938,348

G

DnaJ heat shock protein family (Hsp40) member B9

increases expression

Curcumin results in increased expression of DNAJB9 mRNA

NCBI chr12:44,252,680...44,256,851
Ensembl chr12:44,252,342...44,257,109

G

dynamin 1-like

multiple interactions

Curcumin inhibits the reaction [Potassium Dichromate results in increased expression of DNM1L protein]

NCBI chr16:16,130,092...16,176,863
Ensembl chr16:16,130,094...16,176,823

G

DNA methyltransferase 1

decreases expression
affects expression
increases activity
multiple interactions

Curcumin results in decreased expression of DNMT1 mRNA; Curcumin results in decreased expression of DNMT1 protein
Curcumin analog affects the expression of DNMT1 protein
Curcumin results in increased activity of DNMT1 protein
Curcumin promotes the reaction [Quercetin results in increased activity of DNMT1 protein]; Quercetin promotes the reaction [Curcumin results in increased activity of DNMT1 protein]
Curcumin analog results in decreased expression of DNMT1 protein

PMID:23593078 PMID:26991801 PMID:27132804 PMID:29228771

NCBI chr 9:20,818,501...20,871,084
Ensembl chr 9:20,818,505...20,871,184

G

DNA methyltransferase 3A

decreases expression

Curcumin results in decreased expression of DNMT3A mRNA
Curcumin analog results in decreased expression of DNMT3A protein

PMID:23593078 PMID:26991801 PMID:29228771

NCBI chr12:3,851,559...3,964,442
Ensembl chr12:3,856,007...3,964,443

G

DNA methyltransferase 3B

decreases expression

Curcumin results in decreased expression of DNMT3B mRNA
Curcumin analog results in decreased expression of DNMT3B protein

PMID:23593078 PMID:26991801 PMID:29228771

NCBI chr 2:153,491,332...153,529,650
Ensembl chr 2:153,491,370...153,529,650

G

DNA-damage regulated autophagy modulator 1

increases expression

Curcumin results in increased expression of DRAM1 mRNA

NCBI chr10:88,158,663...88,200,218
Ensembl chr10:88,158,666...88,214,942

G

dopamine receptor D2

multiple interactions

Curcumin inhibits the reaction [sodium arsenite results in decreased expression of DRD2 protein]

NCBI chr 9:49,251,703...49,319,468
Ensembl chr 9:49,251,927...49,319,477

G

dual specificity phosphatase 1

increases expression
multiple interactions

Curcumin results in increased expression of DUSP1 mRNA
Curcumin promotes the reaction [Lipopolysaccharides results in increased phosphorylation of DUSP1 protein]

PMID:15713895 PMID:20885979

NCBI chr17:26,724,565...26,727,446
Ensembl chr17:26,724,564...26,781,102

G

dual specificity phosphatase 10

increases expression

Curcumin results in increased expression of DUSP10 mRNA

PMID:15713895 PMID:17151092

NCBI chr 1:183,766,575...183,807,833
Ensembl chr 1:183,745,499...183,807,833

G

dual specificity phosphatase 5

increases expression

Curcumin results in increased expression of DUSP5 mRNA

NCBI chr19:53,517,576...53,530,240
Ensembl chr19:53,517,540...53,530,862

G

dishevelled segment polarity protein 1

decreases expression
increases expression
multiple interactions

Curcumin results in decreased expression of DVL1 protein
Curcumin results in increased expression of DVL1 mRNA; Curcumin results in increased expression of DVL1 protein
Curcumin inhibits the reaction [bisphenol A results in decreased expression of DVL1 mRNA]; Curcumin inhibits the reaction [bisphenol A results in decreased expression of DVL1 protein]

PMID:19573523 PMID:25963729

NCBI chr 4:155,931,829...155,943,760
Ensembl chr 4:155,931,859...155,943,760

G

dynein light chain LC8-type 1

increases expression

Curcumin results in increased expression of DYNLL1 mRNA

NCBI chr 5:115,435,129...115,438,995
Ensembl chr 5:115,435,169...115,439,058

G

dual-specificity tyrosine phosphorylation regulated kinase 2

decreases activity
multiple interactions

Curcumin results in decreased activity of DYRK2 protein
[Curcumin binds to 4-nitrobenzaldehyde] which results in decreased activity of DYRK2 protein

NCBI chr10:118,691,507...118,725,144
Ensembl chr10:118,691,508...118,706,114

G

E2F transcription factor 1

decreases expression

Curcumin results in decreased expression of E2F1 mRNA

NCBI chr 2:154,401,320...154,411,812
Ensembl chr 2:154,401,327...154,411,812

G

E2F transcription factor 5

decreases expression

Curcumin results in decreased expression of E2F5 mRNA

NCBI chr 3:14,638,370...14,671,369
Ensembl chr 3:14,643,701...14,671,369

G

enoyl coenzyme A hydratase 1, peroxisomal

increases expression

Curcumin results in increased expression of ECH1 mRNA

NCBI chr 7:28,524,763...28,531,664
Ensembl chr 7:28,524,642...28,531,672

G

EDAR associated via death domain

multiple interactions

Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of EDARADD mRNA]

NCBI chr13:12,486,090...12,535,413
Ensembl chr13:12,487,513...12,535,319

G

EGF-like repeats and discoidin I-like domains 3

decreases expression

Curcumin results in decreased expression of EDIL3 mRNA

NCBI chr13:88,969,591...89,471,344
Ensembl chr13:88,969,591...89,471,342

G

epidermal growth factor

decreases activity
multiple interactions

Curcumin results in decreased activity of EGF protein
Curcumin inhibits the reaction [EGF protein results in decreased expression of PPARG mRNA]; Curcumin inhibits the reaction [EGF protein results in decreased expression of PPARG protein]
Curcumin inhibits the reaction [EGF protein results in increased expression of AQP3 protein]; Curcumin inhibits the reaction [EGF protein results in increased phosphorylation of AKT1 protein]; Curcumin inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein]; Curcumin inhibits the reaction [EGF protein results in increased phosphorylation of MAPK1 protein]; Curcumin inhibits the reaction [EGF protein results in increased phosphorylation of MAPK3 protein]; Curcumin inhibits the reaction [EGF protein results in increased secretion of PTHLH protein]

PMID:10851300 PMID:15129424 PMID:15486348 PMID:17372590 PMID:18214481

NCBI chr 3:129,471,223...129,548,971
Ensembl chr 3:129,471,214...129,548,965

G

epidermal growth factor receptor

multiple interactions
decreases phosphorylation
decreases expression

Curcumin inhibits the reaction [Acrylamide results in increased expression of EGFR protein]; Curcumin inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein]; Curcumin promotes the reaction [Folfox protocol results in decreased expression of EGFR protein]; Curcumin promotes the reaction [Folfox protocol results in decreased phosphorylation of and results in decreased activity of EGFR protein]; Curcumin results in decreased expression of and results in decreased activity of EGFR protein; Curcumin results in decreased phosphorylation of and results in decreased activity of EGFR protein; Fluorouracil promotes the reaction [Curcumin results in decreased expression of EGFR protein]; Fluorouracil promotes the reaction [Curcumin results in decreased phosphorylation of and results in decreased activity of EGFR protein]
Curcumin results in decreased phosphorylation of EGFR protein
Curcumin results in decreased expression of EGFR mRNA; Curcumin results in decreased expression of EGFR protein
Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of EGFR mRNA]
Curcumin analog results in decreased expression of EGFR mRNA; Curcumin results in decreased expression of EGFR mRNA; Curcumin results in decreased expression of EGFR protein

PMID:10851300 PMID:15129424 PMID:15486348 PMID:17372590 PMID:17918158 More...

NCBI chr11:16,700,153...16,868,158
Ensembl chr11:16,702,203...16,868,158

G

early growth response 1

multiple interactions
increases expression
decreases expression

EGR1 protein affects the reaction [Curcumin results in increased expression of CDKN1A protein]; EGR1 protein promotes the reaction [Curcumin results in increased expression of CDKN1A mRNA]; pyrazolanthrone inhibits the reaction [Curcumin results in increased expression of EGR1 protein]; U 0126 inhibits the reaction [Curcumin results in increased expression of EGR1 protein]
Curcumin results in increased expression of EGR1 mRNA; Curcumin results in increased expression of EGR1 protein
Curcumin results in decreased expression of EGR1 mRNA

PMID:17198877 PMID:17999991 PMID:18316600

NCBI chr18:34,994,260...34,998,009
Ensembl chr18:34,992,876...34,998,037

G

eukaryotic translation initiation factor 1

decreases expression

Curcumin results in decreased expression of EIF1 mRNA

NCBI chr11:100,210,775...100,212,925
Ensembl chr11:100,210,711...100,212,922

G

eukaryotic translation initiation factor 4E binding protein 1

multiple interactions
decreases expression
decreases phosphorylation

calyculin A inhibits the reaction [Curcumin results in decreased phosphorylation of EIF4EBP1 protein]; Curcumin inhibits the reaction [bisphenol A results in increased expression of EIF4EBP1 protein]
Curcumin results in decreased expression of EIF4EBP1 protein

PMID:18790744 PMID:23222814 PMID:34634291

NCBI chr 8:27,750,355...27,765,684
Ensembl chr 8:27,750,357...27,766,702

G

eukaryotic translation initiation factor 4, gamma 1

decreases phosphorylation

Curcumin results in decreased phosphorylation of EIF4G1 protein

NCBI chr16:20,491,457...20,511,633
Ensembl chr16:20,487,063...20,511,634

G

E74-like factor 2

decreases expression

Curcumin results in decreased expression of ELF2 mRNA

NCBI chr 3:51,160,141...51,248,101
Ensembl chr 3:51,160,141...51,248,084

G

ELK1, member of ETS oncogene family

multiple interactions
increases phosphorylation

Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of ELK1 mRNA]; pyrazolanthrone inhibits the reaction [Curcumin results in increased phosphorylation of ELK1 protein]; U 0126 inhibits the reaction [Curcumin results in increased phosphorylation of ELK1 protein]

PMID:18316600 PMID:23452621

NCBI chr X:20,799,634...20,816,847
Ensembl chr X:20,799,634...20,816,847

G

embigin

multiple interactions

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of EMB mRNA]

NCBI chr13:117,357,109...117,410,951
Ensembl chr13:117,345,072...117,410,951

G

enolase 1, alpha non-neuron

decreases expression

Curcumin results in decreased expression of ENO1 mRNA

NCBI chr 4:150,321,165...150,333,336
Ensembl chr 4:150,321,178...150,333,336

G

ectonucleoside triphosphate diphosphohydrolase 5

increases expression

Curcumin results in increased expression of ENTPD5 mRNA

NCBI chr12:84,420,649...84,455,803
Ensembl chr12:84,420,631...84,455,803

G

E1A binding protein p300

multiple interactions
decreases activity
decreases expression
affects localization

benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Curcumin affects the localization of EP300 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Curcumin results in decreased expression of EP300 mRNA]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Curcumin results in decreased expression of EP300 protein]; Curcumin inhibits the reaction [Dihydrotestosterone promotes the reaction [EP300 protein binds to KLK3 enhancer]]
Curcumin results in decreased activity of EP300 protein
Curcumin inhibits the reaction [AGT protein modified form promotes the reaction [TP53 protein binds to EP300 protein]]; Curcumin inhibits the reaction [Streptozocin results in increased expression of EP300 mRNA]; Curcumin inhibits the reaction [TP53 protein binds to EP300 protein]
Curcumin results in decreased expression of EP300 mRNA; Curcumin results in decreased expression of EP300 protein

PMID:17927689 PMID:22228707 PMID:22258452 PMID:26612707

NCBI chr15:81,470,329...81,536,273
Ensembl chr15:81,469,552...81,536,278

G

endothelial PAS domain protein 1

multiple interactions

Curcumin analog inhibits the reaction [Oxygen deficiency results in increased expression of EPAS1 protein]

NCBI chr17:87,061,292...87,140,838
Ensembl chr17:87,061,128...87,140,838

G

epithelial cell adhesion molecule

decreases expression
multiple interactions

Curcumin results in decreased expression of EPCAM mRNA; Curcumin results in decreased expression of EPCAM protein
WWTR1 protein inhibits the reaction [Curcumin results in decreased expression of EPCAM mRNA]; WWTR1 protein inhibits the reaction [Curcumin results in decreased expression of EPCAM protein]

NCBI chr17:87,943,407...87,958,555
Ensembl chr17:87,943,407...87,958,557

G

erythropoietin

decreases expression

Curcumin results in decreased expression of EPO mRNA

NCBI chr 5:137,481,282...137,484,078
Ensembl chr 5:137,481,282...137,531,504

G

eosinophil peroxidase

multiple interactions

[Dexamethasone co-treated with Curcumin] inhibits the reaction [[Ovalbumin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased activity of EPX protein]; Curcumin inhibits the reaction [[Ovalbumin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased activity of EPX protein]

NCBI chr11:87,754,824...87,766,362
Ensembl chr11:87,754,826...87,766,362

G

erb-b2 receptor tyrosine kinase 2

multiple interactions
increases response to substance
increases degradation
decreases expression

[ERBB2 protein results in increased susceptibility to Curcumin analog] which results in decreased phosphorylation of AK1 protein; [ERBB2 protein results in increased susceptibility to Curcumin analog] which results in decreased phosphorylation of MAPK1 protein; [ERBB2 protein results in increased susceptibility to Curcumin analog] which results in decreased phosphorylation of MAPK3 protein; Curcumin analog inhibits the reaction [ERBB2 protein results in decreased susceptibility to Doxorubicin]; Curcumin analog inhibits the reaction [ERBB2 protein results in decreased susceptibility to Etoposide]; Curcumin analog inhibits the reaction [ERBB2 protein results in decreased susceptibility to Paclitaxel]; Curcumin analog promotes the reaction [Cycloheximide results in increased degradation of ERBB2 protein]; Curcumin promotes the reaction [Fluorouracil results in decreased phosphorylation of and results in decreased expression of and results in decreased activity of ERBB2 protein]; Curcumin promotes the reaction [Folfox protocol results in decreased expression of and results in decreased phosphorylation of and results in decreased activity of ERBB2 protein]; Curcumin results in decreased expression of and results in decreased phosphorylation of and results in decreased activity of ERBB2 protein
ERBB2 protein results in increased susceptibility to Curcumin; ERBB2 protein results in increased susceptibility to Curcumin analog
Curcumin analog results in increased degradation of ERBB2 protein
Curcumin analog results in decreased expression of ERBB2 mRNA; Curcumin analog results in decreased expression of ERBB2 protein; Curcumin results in decreased expression of ERBB2 mRNA; Curcumin results in decreased expression of ERBB2 protein

PMID:17041101 PMID:17918158 PMID:18719366 PMID:25866362 PMID:26409325 More...

NCBI chr11:98,303,310...98,328,542
Ensembl chr11:98,303,296...98,328,542

G

erb-b2 receptor tyrosine kinase 3

multiple interactions
decreases expression

Curcumin promotes the reaction [Folfox protocol results in decreased expression of and results in decreased phosphorylation of and results in decreased activity of ERBB3 protein]; Curcumin results in decreased expression of and results in decreased phosphorylation of and results in decreased activity of ERBB3 protein; Fluorouracil promotes the reaction [Curcumin results in decreased expression of and results in decreased phosphorylation of and results in decreased activity of ERBB3 protein]
Curcumin analog results in decreased expression of ERBB3 mRNA; Curcumin results in decreased expression of ERBB3 mRNA

PMID:15713895 PMID:17918158 PMID:26409325

NCBI chr10:128,403,392...128,425,504
Ensembl chr10:128,403,392...128,425,521

G

excision repair cross-complementing rodent repair deficiency, complementation group 1

multiple interactions
decreases expression

[Curcumin results in decreased expression of ERCC1 protein] which results in increased susceptibility to Cisplatin; Curcumin inhibits the reaction [Glucose results in increased expression of ERCC1 mRNA]; Curcumin inhibits the reaction [Glucose results in increased expression of ERCC1 protein]
Curcumin inhibits the reaction [Streptozocin results in increased expression of ERCC1 mRNA]
Curcumin results in decreased expression of ERCC1 mRNA; Curcumin results in decreased expression of ERCC1 protein

PMID:17596214 PMID:21493726 PMID:22228707

NCBI chr 7:19,079,016...19,090,449
Ensembl chr 7:19,078,703...19,090,449

G

excision repair cross-complementing rodent repair deficiency, complementation group 4

decreases expression
multiple interactions

Curcumin results in decreased expression of ERCC4 mRNA; Curcumin results in decreased expression of ERCC4 protein
Curcumin inhibits the reaction [Streptozocin results in increased expression of ERCC4 mRNA]
Curcumin inhibits the reaction [Glucose results in increased expression of ERCC4 mRNA]; Curcumin inhibits the reaction [Glucose results in increased expression of ERCC4 protein]

NCBI chr16:12,927,600...12,969,873
Ensembl chr16:12,927,548...12,968,481

G

endoplasmic reticulum to nucleus signalling 1

decreases expression
increases expression

Curcumin results in decreased expression of ERN1 mRNA
Curcumin results in increased expression of ERN1 mRNA

PMID:17999991 PMID:29723631

NCBI chr11:106,285,474...106,378,701
Ensembl chr11:106,285,476...106,378,678

G

estrogen receptor 1 (alpha)

multiple interactions
decreases expression

Curcumin inhibits the reaction [bisphenol A results in increased expression of ESR1 protein]; Curcumin inhibits the reaction [Estradiol results in increased degradation of ESR1 protein]; Curcumin inhibits the reaction [Estradiol results in increased phosphorylation of ESR1 protein]; Curcumin inhibits the reaction [fulvestrant results in increased degradation of ESR1 protein]
Curcumin results in decreased expression of ESR1 protein

PMID:15899841 PMID:18347134 PMID:23222814 PMID:24211270

NCBI chr10:4,561,989...4,955,633
Ensembl chr10:4,561,593...4,955,614

G

E26 avian leukemia oncogene 2, 3' domain

decreases expression

Curcumin results in decreased expression of ETS2 protein

NCBI chr16:95,503,274...95,522,093
Ensembl chr16:95,502,942...95,522,095

G

coagulation factor II

multiple interactions

Curcumin inhibits the reaction [F2 protein results in increased expression of ITGA2B protein]; Curcumin inhibits the reaction [F2 protein results in increased expression of ITGB3 protein]; Curcumin inhibits the reaction [F2 protein results in increased expression of SELE protein]; Curcumin inhibits the reaction [F2 protein results in increased expression of SELP protein]

NCBI chr 2:91,442,742...91,466,799
Ensembl chr 2:91,455,665...91,466,759

G

coagulation factor II thrombin receptor

multiple interactions

Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of F2R mRNA]

NCBI chr13:95,738,288...95,754,974
Ensembl chr13:95,738,311...95,754,995

G

coagulation factor III

multiple interactions

Curcumin inhibits the reaction [Heme results in increased expression of F3 mRNA]

NCBI chr 3:121,517,186...121,528,701
Ensembl chr 3:121,517,186...121,528,697

G

Fas associated via death domain

multiple interactions

Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of FADD mRNA]

NCBI chr 7:144,132,060...144,136,178
Ensembl chr 7:144,131,055...144,136,200

G

fatty acid desaturase 1

affects expression
decreases expression

Curcumin affects the expression of FADS1 mRNA
Curcumin results in decreased expression of FADS1 mRNA

NCBI chr19:10,160,245...10,174,238
Ensembl chr19:10,160,252...10,174,241

G

fatty acid desaturase 2

decreases expression
affects expression

Curcumin results in decreased expression of FADS2 mRNA
Curcumin affects the expression of FADS2 mRNA

NCBI chr19:10,040,129...10,078,867
Ensembl chr19:10,040,129...10,079,110

G

family with sequence similarity 120, member B

decreases expression

Curcumin results in decreased expression of FAM120B mRNA

NCBI chr17:15,616,464...15,653,843
Ensembl chr17:15,616,464...15,653,845

G

Fanconi anemia, complementation group D2

multiple interactions
decreases expression

Curcumin inhibits the reaction [Mitomycin results in increased expression of and affects the ubiquitination of FANCD2 protein]
Curcumin results in decreased expression of FANCD2 mRNA

NCBI chr 6:113,508,622...113,573,981
Ensembl chr 6:113,508,643...113,573,978

G

Fanconi anemia, complementation group I

multiple interactions
decreases expression

Curcumin inhibits the reaction [Mitomycin results in increased expression of and affects the ubiquitination of FANCI protein]
Curcumin results in decreased expression of FANCI mRNA

NCBI chr 7:79,042,056...79,100,013
Ensembl chr 7:79,041,677...79,100,012

G

Fas cell surface death receptor

multiple interactions

[arsenic trioxide co-treated with Curcumin] results in increased expression of FAS protein

NCBI chr19:34,267,926...34,305,175
Ensembl chr19:34,268,066...34,305,172

G

Fas ligand

multiple interactions
decreases expression

[arsenic trioxide co-treated with Curcumin] results in increased expression of FASLG protein; Curcumin inhibits the reaction [[vorinostat co-treated with Bortezomib] results in increased expression of FASLG protein]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of FASLG mRNA]
Curcumin results in decreased expression of FASLG mRNA

PMID:10925121 PMID:16101141 PMID:17351739 PMID:23452621 PMID:27430728

NCBI chr 1:161,608,260...161,616,064
Ensembl chr 1:161,608,258...161,616,064

G

fatty acid synthase

affects expression
decreases expression

Curcumin affects the expression of FASN mRNA; Curcumin affects the expression of FASN protein
Curcumin results in decreased expression of FASN mRNA

NCBI chr11:120,696,784...120,715,992
Ensembl chr11:120,696,672...120,715,373

G

fibulin 2

multiple interactions

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of FBLN2 mRNA]

NCBI chr 6:91,189,442...91,249,522
Ensembl chr 6:91,189,437...91,249,522

G

Fc receptor, IgG, low affinity IV

multiple interactions

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of FCGR3A mRNA]

NCBI chr 1:170,846,495...170,857,330
Ensembl chr 1:170,846,489...170,857,330

G

farnesyl diphosphate farnesyl transferase 1

decreases expression

Curcumin results in decreased expression of FDFT1 mRNA

NCBI chr14:63,382,599...63,419,136
Ensembl chr14:63,382,599...63,417,027

G

farnesyl diphosphate synthetase

increases expression
decreases expression
affects expression

Curcumin results in increased expression of FDPS mRNA
Curcumin results in decreased expression of FDPS mRNA
Curcumin affects the expression of FDPS mRNA

PMID:16713233 PMID:27208389

NCBI chr 3:89,000,895...89,009,274
Ensembl chr 3:89,000,895...89,009,266

G

fibroblast growth factor 2

decreases expression
increases expression

Curcumin results in decreased expression of FGF2 protein
Curcumin results in increased expression of FGF2 protein

NCBI chr 3:37,402,616...37,464,255
Ensembl chr 3:37,402,495...37,464,257

G

fibroblast growth factor 5

decreases expression

Curcumin results in decreased expression of FGF5 mRNA

NCBI chr 5:98,402,108...98,424,892
Ensembl chr 5:98,402,043...98,424,889

G

fibroblast growth factor receptor 2

decreases expression

Curcumin results in decreased expression of FGFR2 mRNA

NCBI chr 7:129,764,181...129,868,538
Ensembl chr 7:129,764,181...132,725,079

G

filamin A interacting protein 1-like

increases expression

Curcumin results in increased expression of FILIP1L mRNA

NCBI chr16:57,173,376...57,393,167
Ensembl chr16:57,173,456...57,393,489

G

fission, mitochondrial 1

multiple interactions

Curcumin inhibits the reaction [Cisplatin results in increased expression of FIS1 protein]

NCBI chr 5:136,982,129...136,995,088
Ensembl chr 5:136,982,129...136,995,088

G

FMS-like tyrosine kinase 1

decreases expression
multiple interactions

Curcumin results in decreased expression of FLT1 protein
Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of FLT1 protein]

PMID:18593936 PMID:23845850

NCBI chr 5:147,498,414...147,663,419
Ensembl chr 5:147,498,414...147,662,821

G

fibronectin 1

multiple interactions
decreases expression

Curcumin inhibits the reaction [Glucose results in increased expression of FN1 mRNA]; Curcumin inhibits the reaction [Glucose results in increased expression of FN1 protein]
Curcumin inhibits the reaction [sphingosine 1-phosphate results in increased expression of FN1 protein]; Curcumin inhibits the reaction [Streptozocin results in increased expression of FN1 mRNA]
Curcumin results in decreased expression of FN1 mRNA
Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of FN1 mRNA]

PMID:12388107 PMID:18200517 PMID:18555241 PMID:21998146 PMID:22228707

NCBI chr 1:71,624,632...71,692,439
Ensembl chr 1:71,624,679...71,692,359

G

farnesyltransferase, CAAX box, beta

increases expression

Curcumin results in increased expression of FNTB mRNA

NCBI chr12:76,884,014...76,968,188
Ensembl chr12:76,812,363...76,968,186

G

FBJ osteosarcoma oncogene

decreases expression
multiple interactions
increases expression

Curcumin results in decreased expression of FOS mRNA
Curcumin inhibits the reaction [Tobacco Smoke Pollution results in increased phosphorylation of FOS protein]
Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of FOS mRNA]
Curcumin results in increased expression of FOS mRNA
[Curcumin co-treated with Manganese] inhibits the reaction [Kainic Acid results in increased expression of FOS protein]

PMID:15713895 PMID:17827730 PMID:17999991 PMID:23452621 PMID:26191140

NCBI chr12:85,520,664...85,524,048
Ensembl chr12:85,520,664...85,524,047

G

fos-like antigen 1

multiple interactions
increases ubiquitination

benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of FOSL1 protein]]; Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate promotes the reaction [FOSL1 protein binds to JUNB protein]]; Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of FOSL1 protein]
Curcumin results in increased ubiquitination of FOSL1 protein

NCBI chr19:5,497,726...5,505,966
Ensembl chr19:5,497,575...5,505,974

G

fos-like antigen 2

decreases expression
multiple interactions

Curcumin results in decreased expression of FOSL2 mRNA
Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of FOSL2 protein]

PMID:17148446 PMID:17999991

NCBI chr 5:32,292,599...32,315,184
Ensembl chr 5:32,293,145...32,315,186

G

forkhead box A1

multiple interactions

Curcumin inhibits the reaction [Dihydrotestosterone promotes the reaction [FOXA1 protein binds to KLK3 enhancer]]; Curcumin inhibits the reaction [Dihydrotestosterone promotes the reaction [FOXA1 protein binds to TMPRSS2 enhancer]]

NCBI chr12:57,585,750...57,594,815
Ensembl chr12:57,587,414...57,593,702

G

forkhead box A2

decreases expression

Curcumin results in decreased expression of FOXA2 mRNA

NCBI chr 2:147,884,797...147,888,889
Ensembl chr 2:147,884,797...147,888,889

G

forkhead box F2

decreases expression

Curcumin results in decreased expression of FOXF2 mRNA

NCBI chr13:31,809,686...31,815,390
Ensembl chr13:31,809,799...31,815,386

G

forkhead box O1

increases expression
decreases phosphorylation

Curcumin results in increased expression of FOXO1 mRNA
Curcumin results in decreased phosphorylation of FOXO1 protein

PMID:18403477 PMID:18790744

NCBI chr 3:52,175,758...52,257,530
Ensembl chr 3:52,175,757...52,260,642

G

formyl peptide receptor 3

multiple interactions

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of FPR3 mRNA]

NCBI chr17:18,190,720...18,191,939
Ensembl chr17:18,108,114...18,191,939

G

follicle stimulating hormone beta

multiple interactions

Curcumin inhibits the reaction [sodium arsenite results in decreased expression of FSHB protein]

NCBI chr 2:106,886,331...106,889,996
Ensembl chr 2:106,886,485...106,890,001

G

follistatin-like 1

multiple interactions

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of FSTL1 mRNA]

NCBI chr16:37,597,417...37,656,878
Ensembl chr16:37,597,235...37,656,876

G

ferritin light polypeptide 1

decreases expression

Curcumin results in decreased expression of FTL1 mRNA

NCBI chr 7:45,107,368...45,109,310
Ensembl chr 7:45,107,368...45,109,308

G

fused in sarcoma

increases expression
decreases expression

Curcumin results in increased expression of FUS mRNA
Curcumin results in decreased expression of FUS mRNA

PMID:17198877 PMID:17999991

NCBI chr 7:127,565,276...127,581,204
Ensembl chr 7:127,566,629...127,584,873

G

frizzled class receptor 1

decreases expression

Curcumin results in decreased expression of FZD1 mRNA

NCBI chr 5:4,803,839...4,808,216
Ensembl chr 5:4,803,839...4,808,035

G

glucose-6-phosphatase catalytic subunit 1

affects expression

Curcumin affects the expression of G6PC1 mRNA

NCBI chr11:101,258,542...101,268,729
Ensembl chr11:101,258,387...101,268,729

G

glucose-6-phosphate dehydrogenase X-linked

increases expression
multiple interactions

Curcumin results in increased expression of G6PD mRNA; Curcumin results in increased expression of G6PDX mRNA
Curcumin inhibits the reaction [Hypochlorous Acid results in decreased activity of G6PD protein]

PMID:18299980 PMID:36924976

NCBI chr X:73,453,089...73,472,486
Ensembl chr X:73,453,089...73,472,800

G

gamma-aminobutyric acid type A receptor subunit alpha 1

decreases expression

Curcumin results in decreased expression of GABRA1 mRNA

NCBI chr11:42,021,766...42,073,893
Ensembl chr11:42,021,766...42,073,757

G

glutamate decarboxylase 1

multiple interactions

Curcumin inhibits the reaction [Streptozocin results in decreased expression of GAD1 mRNA]

NCBI chr 2:70,392,109...70,432,358
Ensembl chr 2:70,383,416...70,432,358

G

growth arrest and DNA-damage-inducible 45 alpha

increases expression

Curcumin results in increased expression of GADD45A mRNA

PMID:16101141 PMID:18299980 PMID:18719366

NCBI chr 6:67,012,080...67,014,391
Ensembl chr 6:67,012,080...67,014,441

G

growth arrest specific 6

increases expression

Curcumin results in increased expression of GAS6 mRNA

NCBI chr 8:13,515,374...13,544,535
Ensembl chr 8:13,515,374...13,544,490

G

GATA binding protein 2

multiple interactions

Curcumin inhibits the reaction [Dihydrotestosterone promotes the reaction [GATA2 protein binds to KLK3 enhancer]]; Curcumin inhibits the reaction [Dihydrotestosterone promotes the reaction [GATA2 protein binds to TMPRSS2 enhancer]]; Curcumin inhibits the reaction [GATA2 protein results in increased expression of KLK3 mRNA]

NCBI chr 6:88,170,873...88,184,014
Ensembl chr 6:88,170,873...88,184,014

G

GATA binding protein 4

decreases expression

Curcumin results in decreased expression of GATA4 mRNA; Curcumin results in decreased expression of GATA4 protein

NCBI chr14:63,436,363...63,509,161
Ensembl chr14:63,436,371...63,509,141

G

glutamate-cysteine ligase, catalytic subunit

increases activity
multiple interactions
increases expression

Curcumin results in increased activity of GCLC protein
Curcumin inhibits the reaction [Aflatoxin B1 results in decreased expression of GCLC mRNA]; Curcumin inhibits the reaction [deoxynivalenol results in decreased expression of GCLC mRNA]; Curcumin promotes the reaction [sodium arsenite results in increased expression of GCLC protein]; NFE2L2 gene mutant form inhibits the reaction [Curcumin results in increased expression of GCLC mRNA]
Curcumin analog results in increased expression of GCLC mRNA; Curcumin results in increased expression of GCLC mRNA
Curcumin inhibits the reaction [Hydrogen Peroxide results in decreased expression of GCLC mRNA]; NFE2L2 mutant form inhibits the reaction [Curcumin analog results in increased expression of GCLC mRNA]; NFE2L2 mutant form inhibits the reaction [Curcumin results in increased expression of GCLC mRNA]
Curcumin results in increased expression of GCLC mRNA; Curcumin results in increased expression of GCLC protein
Curcumin inhibits the reaction [Ketamine results in decreased expression of GCLC mRNA]; Curcumin inhibits the reaction [Ketamine results in decreased expression of GCLC protein]; Curcumin promotes the reaction [[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of GCLC mRNA]; Curcumin promotes the reaction [[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of GCLC protein]; Curcumin results in increased activity of [GCLC protein binds to GCLM protein]

PMID:10514034 PMID:17602960 PMID:18299980 PMID:18332871 PMID:19168576 More...

NCBI chr 9:77,661,817...77,701,771
Ensembl chr 9:77,661,817...77,701,767

G

glutamate-cysteine ligase, modifier subunit

multiple interactions
increases expression

Curcumin results in increased activity of [GCLC protein binds to GCLM protein]
Curcumin promotes the reaction [sodium arsenite results in increased expression of GCLM mRNA]
Curcumin analog results in increased expression of GCLM mRNA; Curcumin results in increased expression of GCLM mRNA; Curcumin results in increased expression of GCLM protein
NFE2L2 mutant form inhibits the reaction [Curcumin analog results in increased expression of GCLM mRNA]; NFE2L2 mutant form inhibits the reaction [Curcumin results in increased expression of GCLM mRNA]

PMID:17198877 PMID:17535857 PMID:17602960 PMID:17999991 PMID:18332871 More...

NCBI chr 3:122,039,206...122,060,864
Ensembl chr 3:122,039,206...122,064,381

G

guanine deaminase

multiple interactions

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of GDA mRNA]

NCBI chr19:21,368,671...21,450,025
Ensembl chr19:21,368,671...21,450,809

G

glial fibrillary acidic protein

decreases expression
multiple interactions

Curcumin results in decreased expression of GFAP mRNA
Curcumin inhibits the reaction [bisphenol A results in increased expression of GFAP mRNA]

PMID:19555370 PMID:25963729

NCBI chr11:102,778,162...102,791,368
Ensembl chr11:102,778,162...102,791,738

G

gamma-glutamyltransferase 1

increases expression
multiple interactions

Curcumin results in increased expression of GGT1 mRNA
Curcumin inhibits the reaction [Thioacetamide results in increased expression of GGT1 protein]

PMID:18299980 PMID:24704557

NCBI chr10:75,396,910...75,422,027
Ensembl chr10:75,397,438...75,422,034

G

glycoprotein galactosyltransferase alpha 1, 3

multiple interactions

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of GGTA1 mRNA]

NCBI chr 2:35,290,191...35,354,393
Ensembl chr 2:35,290,191...35,353,243

G

gap junction protein, alpha 1

multiple interactions

Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of GJA1 mRNA]

NCBI chr10:56,253,297...56,266,519
Ensembl chr10:56,253,426...56,278,609

G

GLI-Kruppel family member GLI1

decreases expression
multiple interactions

Curcumin results in decreased expression of GLI1 mRNA; Curcumin results in decreased expression of GLI1 protein
[Arsenic Trioxide co-treated with Curcumin] inhibits the reaction [Cisplatin results in increased expression of GLI1 protein]; Curcumin inhibits the reaction [Cisplatin results in increased expression of GLI1 protein]

PMID:20395211 PMID:31612257

NCBI chr10:127,165,751...127,177,448
Ensembl chr10:127,165,751...127,177,843

G

GLI-Kruppel family member GLI2

multiple interactions

Curcumin inhibits the reaction [Cisplatin results in increased expression of GLI2 protein]; Curcumin promotes the reaction [Arsenic Trioxide inhibits the reaction [Cisplatin results in increased expression of GLI2 protein]]

NCBI chr 1:118,761,791...118,987,578
Ensembl chr 1:118,761,862...118,981,349

G

glyoxalase 1

decreases activity

Curcumin results in decreased activity of GLO1 protein

NCBI chr17:30,811,835...30,831,633
Ensembl chr17:30,803,910...30,845,845

G

glutamic-oxaloacetic transaminase 1, soluble

multiple interactions

Curcumin inhibits the reaction [aristolochic acid I results in increased activity of GOT1 protein]; Curcumin inhibits the reaction [ferric sulfate results in increased activity of GOT1 protein]; Curcumin inhibits the reaction [Iron results in increased activity of GOT1 protein]

PMID:16956363 PMID:36037877

NCBI chr19:43,488,191...43,514,743
Ensembl chr19:43,488,191...43,513,044

G

glutamic-oxaloacetic transaminase 1-like 1

multiple interactions

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of GOT1L1 mRNA]

NCBI chr 8:27,687,487...27,713,872
Ensembl chr 8:27,687,487...27,713,856

G

glycerol-3-phosphate acyltransferase, mitochondrial

decreases expression
affects expression
multiple interactions

Curcumin results in decreased expression of GPAM mRNA
Curcumin affects the expression of GPAM mRNA
Curcumin inhibits the reaction [Dietary Fats results in increased expression of GPAM mRNA]

PMID:19297423 PMID:27208389

NCBI chr19:55,056,067...55,115,666
Ensembl chr19:55,055,700...55,115,670

G

G protein-coupled estrogen receptor 1

decreases expression

Curcumin results in decreased expression of GPER1 mRNA

NCBI chr 5:139,408,905...139,413,555
Ensembl chr 5:139,408,906...139,413,555

G

gephyrin

affects expression

Curcumin affects the expression of GPHN mRNA

NCBI chr12:78,264,099...78,731,546
Ensembl chr12:78,273,153...78,731,546

G

glutamic pyruvic transaminase, soluble

multiple interactions

[Curcumin analog co-treated with Hydrogels] inhibits the reaction [Aflatoxin B1 results in increased activity of GPT protein]; Curcumin inhibits the reaction [Acetaminophen affects the activity of GPT protein]; Curcumin inhibits the reaction [aristolochic acid I results in increased activity of GPT protein]; Curcumin inhibits the reaction [Cadmium Chloride results in increased activity of GPT protein]; Curcumin inhibits the reaction [Fenitrothion results in increased expression of GPT protein]; Curcumin inhibits the reaction [ferric sulfate results in increased activity of GPT protein]; Curcumin inhibits the reaction [Iron results in increased activity of GPT protein]; Curcumin inhibits the reaction [Thioacetamide results in increased activity of GPT protein]; Curcumin inhibits the reaction [Thioacetamide results in increased expression of GPT protein]; pomegranate fruit rind promotes the reaction [Curcumin inhibits the reaction [Thioacetamide results in increased activity of GPT protein]]
Curcumin inhibits the reaction [Aflatoxin B1 results in increased activity of GPT protein]; Curcumin inhibits the reaction [bisphenol A results in increased activity of GPT protein]; Curcumin inhibits the reaction [Chloranil results in increased activity of GPT protein]; Curcumin metabolite inhibits the reaction [Acetaminophen results in increased expression of GPT protein]

PMID:16956363 PMID:20804811 PMID:24704557 PMID:25123790 PMID:27288928 More...

NCBI chr15:76,580,926...76,583,875
Ensembl chr15:76,579,916...76,583,886

G

glutathione peroxidase 1

decreases expression
multiple interactions

Curcumin results in decreased expression of GPX1 mRNA
Curcumin inhibits the reaction [Hypochlorous Acid results in increased activity of GPX1 protein]
Curcumin inhibits the reaction [sodium arsenite results in decreased expression of GPX1 mRNA]
[Curcumin co-treated with Vitamin E] inhibits the reaction [Thyroxine results in increased expression of GPX1 protein]; Curcumin inhibits the reaction [Streptozocin results in decreased expression of GPX1 mRNA]; Curcumin inhibits the reaction [Thyroxine results in decreased expression of GPX1 mRNA]

PMID:18299980 PMID:19914224 PMID:23267840 PMID:30934151 PMID:36924976

NCBI chr 9:108,216,279...108,217,541
Ensembl chr 9:108,216,102...108,217,542

G

growth factor receptor bound protein 10

multiple interactions

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of GRB10 mRNA]

NCBI chr11:11,880,499...11,987,428
Ensembl chr11:11,880,508...11,988,683

G

growth factor receptor bound protein 2

decreases expression

Curcumin analog results in decreased expression of GRB2 mRNA

NCBI chr11:115,534,871...115,599,423
Ensembl chr11:115,534,871...115,599,423

G

gremlin 1, DAN family BMP antagonist

multiple interactions

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of GREM1 mRNA]

NCBI chr 2:113,579,020...113,588,993
Ensembl chr 2:113,576,509...113,588,991

G

glutamate receptor, ionotropic, AMPA4 (alpha 4)

multiple interactions

Curcumin inhibits the reaction [Streptozocin results in increased expression of GRIA4 protein]

NCBI chr 9:4,417,893...4,796,250
Ensembl chr 9:4,417,896...4,796,234

G

glutamate receptor, ionotropic, NMDA1 (zeta 1)

multiple interactions

Curcumin inhibits the reaction [sodium arsenite results in decreased expression of GRIN1 mRNA]; Curcumin inhibits the reaction [sodium arsenite results in decreased expression of GRIN1 protein]; Curcumin inhibits the reaction [Streptozocin results in increased expression of GRIN1 mRNA]; Curcumin inhibits the reaction [Streptozocin results in increased expression of GRIN1 protein]

PMID:23267840 PMID:29723552

NCBI chr 2:25,181,189...25,209,199
Ensembl chr 2:25,181,193...25,209,199

G

glutamate receptor, ionotropic, NMDA2A (epsilon 1)

multiple interactions

Curcumin inhibits the reaction [aluminum acetate results in decreased expression of GRIN2A protein]; Curcumin inhibits the reaction [sodium arsenite results in decreased expression of GRIN2A mRNA]; Curcumin inhibits the reaction [sodium arsenite results in decreased expression of GRIN2A protein]

PMID:25496357 PMID:29723552

NCBI chr16:9,385,765...9,813,744
Ensembl chr16:9,385,762...9,813,424

G

glutamate receptor, ionotropic, NMDA2B (epsilon 2)

multiple interactions

Curcumin inhibits the reaction [aluminum acetate results in decreased expression of GRIN2B protein]

NCBI chr 6:135,690,219...136,150,658
Ensembl chr 6:135,690,231...136,150,509

G

glutamate receptor, metabotropic 2

decreases expression

Curcumin results in decreased expression of GRM2 protein

NCBI chr 9:106,521,733...106,533,308
Ensembl chr 9:106,520,294...106,533,281

G

gasdermin D

multiple interactions

[Dexamethasone co-treated with Curcumin] inhibits the reaction [[Ovalbumin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of GSDMD protein]; Curcumin inhibits the reaction [Aflatoxin B1 results in increased expression of GSDMD mRNA]; Curcumin inhibits the reaction [Aflatoxin B1 results in increased expression of GSDMD protein]

PMID:34998855 PMID:35063475

NCBI chr15:75,733,990...75,739,257
Ensembl chr15:75,734,176...75,739,257

G

glycogen synthase kinase 3 beta

decreases phosphorylation
decreases expression
multiple interactions
increases phosphorylation
increases expression

Curcumin results in decreased phosphorylation of GSK3B protein
Curcumin results in decreased expression of GSK3B mRNA
Curcumin inhibits the reaction [IL1B protein results in decreased expression of GSK3B mRNA]; Curcumin inhibits the reaction [IL1B protein results in increased expression of GSK3B protein]; Curcumin results in increased expression of and results in increased phosphorylation of GSK3B protein
Curcumin results in increased phosphorylation of GSK3B protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Curcumin inhibits the reaction [sodium arsenite results in decreased phosphorylation of GSK3B protein]]; Curcumin inhibits the reaction [[Copper Sulfate results in increased abundance of Copper] which results in decreased phosphorylation of GSK3B protein]; Curcumin inhibits the reaction [bisphenol A results in decreased phosphorylation of GSK3B protein]; Curcumin inhibits the reaction [bisphenol A results in increased expression of GSK3B mRNA]; Curcumin inhibits the reaction [bisphenol A results in increased phosphorylation of and affects the localization of GSK3B protein]; Curcumin inhibits the reaction [sodium arsenite results in decreased phosphorylation of GSK3B protein]; Curcumin inhibits the reaction [Streptozocin results in decreased phosphorylation of GSK3B protein]
Curcumin results in increased expression of GSK3B protein

PMID:18006147 PMID:18790744 PMID:19573523 PMID:25541178 PMID:25963729 More...

NCBI chr16:37,909,363...38,066,446
Ensembl chr16:37,909,363...38,066,446

G

gelsolin

multiple interactions

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of GSN mRNA]

NCBI chr 2:35,146,371...35,197,914
Ensembl chr 2:35,146,392...35,197,904

G

glutathione reductase

increases expression
multiple interactions

Curcumin results in increased expression of GSR mRNA
Curcumin inhibits the reaction [Hypochlorous Acid results in decreased activity of GSR protein]
[Curcumin co-treated with resveratrol] inhibits the reaction [Benzo(a)pyrene results in decreased activity of GSR protein]; Curcumin inhibits the reaction [sodium arsenite results in decreased expression of GSR]
[Curcumin co-treated with Vitamin E] inhibits the reaction [Thyroxine results in decreased expression of GSR mRNA]; Curcumin analog inhibits the reaction [Monocrotaline results in increased activity of GSR protein]; Curcumin analog inhibits the reaction [sodium arsenite results in decreased activity of GSR protein]; Curcumin inhibits the reaction [Fenitrothion results in decreased activity of GSR protein]; Curcumin inhibits the reaction [Hexachlorocyclohexane results in decreased activity of GSR protein]; Curcumin inhibits the reaction [sodium arsenite results in decreased activity of GSR protein]; Curcumin inhibits the reaction [Thyroxine results in decreased expression of GSR mRNA]

PMID:19168576 PMID:19914224 PMID:20593964 PMID:21976817 PMID:24347089 More...

NCBI chr 8:34,143,266...34,188,190
Ensembl chr 8:34,142,551...34,188,191

G

glutathione synthetase

increases expression
multiple interactions

Curcumin results in increased expression of GSS mRNA
Curcumin inhibits the reaction [Aflatoxin B1 results in decreased expression of GSS mRNA]

PMID:19183254 PMID:35063475

NCBI chr 2:155,405,101...155,434,730
Ensembl chr 2:155,405,101...155,434,730

G

glutathione S-transferase, alpha 1 (Ya)

increases expression

Curcumin results in increased expression of GSTA5 mRNA

NCBI chr 9:78,137,951...78,149,965
Ensembl chr 9:78,137,938...78,149,966

G

glutathione S-transferase, alpha 2 (Yc2)

increases expression

Curcumin results in increased expression of GSTA2 mRNA

NCBI chr 9:78,238,300...78,254,474
Ensembl chr 9:78,238,300...78,263,070

G

glutathione S-transferase kappa 1

multiple interactions

Curcumin inhibits the reaction [Hydrogen Peroxide results in decreased expression of GSTK1 mRNA]

NCBI chr 6:42,222,869...42,227,375
Ensembl chr 6:42,222,869...42,227,381

G

glutathione S-transferase omega 1

increases expression
multiple interactions

Curcumin results in increased expression of GSTO1 mRNA
Curcumin promotes the reaction [sodium arsenite results in increased expression of GSTO1 mRNA]

NCBI chr19:47,843,412...47,853,229
Ensembl chr19:47,843,409...47,853,229

G

glutathione S-transferase, pi 1

multiple interactions
affects expression
increases expression
decreases expression

[sulfinosine co-treated with Curcumin] results in decreased expression of GSTP1 mRNA; Curcumin binds to and results in decreased activity of GSTP1 protein; Curcumin inhibits the reaction [GSTP1 protein results in decreased susceptibility to Etoposide]; Curcumin inhibits the reaction [TNF protein results in increased expression of GSTP1 mRNA]; Curcumin promotes the reaction [NFE2L2 protein binds to GSTP1 promoter]; Curcumin promotes the reaction [NFE2L2 protein results in increased expression of GSTP1 mRNA]
Curcumin affects the expression of GSTP1 protein
Curcumin results in increased expression of GSTP1 mRNA
Curcumin results in increased expression of GSTP1 mRNA; Curcumin results in increased expression of GSTP1 protein
Curcumin results in decreased expression of GSTP1 mRNA; Curcumin results in decreased expression of GSTP1 protein

PMID:9463521 PMID:14555224 PMID:14742295 PMID:15999103 PMID:16101141 More...

NCBI chr19:4,085,411...4,087,912
Ensembl chr19:4,085,407...4,087,985

G

glucuronidase, beta

multiple interactions

Curcumin inhibits the reaction [Isoproterenol results in increased activity of GUSB protein]

NCBI chr 5:130,011,278...130,031,890
Ensembl chr 5:130,017,852...130,031,890

G

H19, imprinted maternally expressed transcript

decreases expression
multiple interactions

Curcumin results in decreased expression of H19 mRNA
curcumin inhibits the reaction [platelet- derived growth factor increases expression of H19 RNA in aortic vascular smooth muscle cells]
curcumin inhibits the reaction [carotid balloon injury increases expression of H19 RNA in carotid artery segment]

CTD
RGD

PMID:18348204 PMID:34487706 PMID:34487706

RGD:156430326, RGD:156430326

NCBI chr 7:142,129,267...142,131,883
Ensembl chr 7:142,129,262...142,131,917

G

H1.10 linker histone

decreases expression

Curcumin results in decreased expression of H1-10 mRNA

NCBI chr 6:87,957,403...87,958,464
Ensembl chr 6:87,957,403...87,958,619

G

H2A.X variant histone

multiple interactions
increases phosphorylation

[Curcumin co-treated with Metribolone] results in increased phosphorylation of H2AX protein; [Isoflavones co-treated with Curcumin] results in increased phosphorylation of H2AX protein
Curcumin results in increased phosphorylation of H2AX protein

PMID:19401701 PMID:21134073

NCBI chr 9:44,246,012...44,247,374
Ensembl chr 9:44,245,991...44,247,374

G

H2B clustered histone 14

increases expression

Curcumin results in increased expression of H2BC5 mRNA

NCBI chr13:21,906,214...21,906,696
Ensembl chr13:21,906,214...21,906,737

G

H2B clustered histone 26

increases expression

Curcumin results in increased expression of H2BC26 mRNA

NCBI chr11:58,842,961...58,845,278
Ensembl chr11:58,844,874...58,845,254

G

H3.4 histone, cluster member

increases phosphorylation
increases acetylation

Curcumin results in increased phosphorylation of H3F4 protein
Curcumin results in increased acetylation of H3F4 protein

NCBI chr11:58,852,537...58,853,099
Ensembl chr11:58,852,599...58,853,364

G

H4 clustered histone 11

increases expression

Curcumin results in increased expression of H4C11 mRNA

NCBI chr13:21,919,204...21,919,626
Ensembl chr13:21,919,234...21,920,007

G

H4 clustered histone 4

increases expression

Curcumin results in increased expression of H4C15 mRNA

NCBI chr13:23,765,551...23,765,952
Ensembl chr13:23,765,581...23,766,718

G

hepcidin antimicrobial peptide

decreases expression

Curcumin results in decreased expression of HAMP mRNA

NCBI chr 7:30,641,793...30,643,454
Ensembl chr 7:30,641,793...30,643,457

G

heart and neural crest derivatives expressed 1

multiple interactions
decreases expression

Curcumin inhibits the reaction [Alcohols results in increased expression of HAND1 mRNA]
Curcumin results in decreased expression of HAND1 mRNA

NCBI chr11:57,719,539...57,722,973
Ensembl chr11:57,719,531...57,723,644

G

heart and neural crest derivatives expressed 2

multiple interactions
decreases expression

Curcumin inhibits the reaction [Alcohols results in increased expression of HAND2 mRNA]
Curcumin results in decreased expression of HAND2 mRNA

NCBI chr 8:57,774,018...57,777,552
Ensembl chr 8:57,774,018...57,777,668

G

hepatitis A virus cellular receptor 1

multiple interactions

Curcumin analog inhibits the reaction [Copper Sulfate results in increased expression of HAVCR1 protein]; Curcumin inhibits the reaction [Cadmium Chloride results in increased export of HAVCR1 protein]; Curcumin inhibits the reaction [Copper Sulfate results in increased expression of HAVCR1 protein]; Curcumin inhibits the reaction [maleic acid results in increased expression of HAVCR1 protein]

PMID:25119790 PMID:29421648 PMID:30431687

NCBI chr11:46,630,644...46,670,405
Ensembl chr11:46,625,907...46,670,405

G

Hbs1-like (S. cerevisiae)

decreases expression

Curcumin results in decreased expression of HBS1L mRNA

NCBI chr10:21,171,876...21,244,788
Ensembl chr10:21,171,878...21,244,797

G

hemopoietic cell kinase

decreases activity
multiple interactions

Curcumin analog results in decreased activity of HCK protein
[Curcumin binds to 3,4,5-trimethoxybenzaldehyde] which results in decreased activity of HCK protein; [Curcumin binds to 4-bis(2-chloroethyl)aminobenzaldehyde] inhibits the reaction [HCK protein binds to Adenosine Triphosphate]; [Curcumin binds to 4-bis(2-chloroethyl)aminobenzaldehyde] which binds to and results in decreased phosphorylation of and results in decreased activity of HCK protein

NCBI chr 2:152,950,388...152,993,361
Ensembl chr 2:152,950,388...152,993,361

G

histone deacetylase 1

multiple interactions
decreases expression
affects localization

benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Curcumin affects the localization of HDAC1 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Curcumin results in decreased expression of HDAC1 mRNA]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Curcumin results in decreased expression of HDAC1 protein]
Curcumin analog results in decreased expression of HDAC1 protein
Curcumin analog results in decreased expression of HDAC1 mRNA; Curcumin results in decreased expression of HDAC1 mRNA; Curcumin results in decreased expression of HDAC1 protein

PMID:17927689 PMID:18161303 PMID:23593078 PMID:26409325 PMID:29228771

NCBI chr 4:129,409,897...129,436,516
Ensembl chr 4:129,409,897...129,436,506

G

histone deacetylase 11

decreases expression

Curcumin analog results in decreased expression of HDAC11 mRNA

NCBI chr 6:91,133,652...91,151,674
Ensembl chr 6:91,133,647...91,151,674

G

histone deacetylase 2

multiple interactions
decreases expression

Curcumin inhibits the reaction [Hydrogen Peroxide results in decreased activity of HDAC2 protein]; Curcumin inhibits the reaction [Smoke results in decreased activity of HDAC2 protein]; Curcumin inhibits the reaction [Smoke results in increased degradation of and results in decreased expression of HDAC2 protein]
Curcumin analog results in decreased expression of HDAC2 mRNA

PMID:18421014 PMID:26409325

NCBI chr10:36,850,293...36,877,885
Ensembl chr10:36,850,540...36,877,885

G

histone deacetylase 3

decreases expression

Curcumin results in decreased expression of HDAC3 protein

NCBI chr18:38,070,024...38,088,073
Ensembl chr18:38,068,897...38,088,069

G

histone deacetylase 4

decreases expression

Curcumin analog results in decreased expression of HDAC4 mRNA
Curcumin analog results in decreased expression of HDAC4 protein

PMID:26409325 PMID:26991801 PMID:29228771

NCBI chr 1:91,856,501...92,123,424
Ensembl chr 1:91,856,501...92,123,421

G

histone deacetylase 6

decreases expression

Curcumin analog results in decreased expression of HDAC6 mRNA

NCBI chr X:7,796,355...7,814,284
Ensembl chr X:7,796,359...7,814,128

G

histone deacetylase 7

decreases expression

Curcumin analog results in decreased expression of HDAC7 protein

NCBI chr15:97,690,542...97,742,383
Ensembl chr15:97,690,545...97,742,383

G

histone deacetylase 8

decreases expression

Curcumin analog results in decreased expression of HDAC8 mRNA

NCBI chr X:101,328,244...101,549,005
Ensembl chr X:101,328,245...101,548,965

G

heme binding protein 2

multiple interactions

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of HEBP2 mRNA]

NCBI chr10:18,415,871...18,421,824
Ensembl chr10:18,415,246...18,421,824

G

hes family bHLH transcription factor 1

multiple interactions

[1,2-Dimethylhydrazine co-treated with Curcumin] results in increased expression of HES1 mRNA

NCBI chr16:29,883,259...29,886,614
Ensembl chr16:29,883,202...29,886,614

G

hepatocyte growth factor

increases expression
decreases expression

Curcumin results in increased expression of HGF protein
Curcumin results in decreased expression of HGF protein

NCBI chr 5:16,758,493...16,827,448
Ensembl chr 5:16,758,493...16,825,150

G

hypoxia inducible factor 1, alpha subunit

multiple interactions
decreases expression
decreases activity

[Curcumin analog co-treated with Sirolimus] inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A protein]; [Curcumin analog co-treated with terpestacin] inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A protein]; [Curcumin analog co-treated with vorinostat] inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A protein]; Curcumin analog inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [Oxygen deficiency results in increased expression of HIF1A protein]]; Curcumin analog inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of HIF1A protein modified form]; Curcumin analog inhibits the reaction [Ionomycin promotes the reaction [Oxygen deficiency results in increased activity of HIF1A protein]]; Curcumin analog inhibits the reaction [Ionomycin results in increased activity of HIF1A protein]; Curcumin analog inhibits the reaction [Oxygen deficiency results in increased expression of and results in increased activity of HIF1A protein]; Curcumin results in decreased expression of and results in decreased activity of HIF1A protein; VHL protein promotes the reaction [Curcumin results in decreased expression of HIF1A protein]
Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of HIF1A mRNA]; Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of HIF1A protein]
Curcumin results in decreased expression of HIF1A mRNA
Curcumin analog results in decreased expression of HIF1A mRNA; Curcumin results in decreased expression of HIF1A mRNA
Curcumin results in decreased activity of HIF1A protein

PMID:16880289 PMID:18682687 PMID:20554536 PMID:21397623 PMID:23845850 More...

NCBI chr12:73,948,186...73,994,304
Ensembl chr12:73,948,149...73,994,304

G

hexokinase 1

multiple interactions

Curcumin inhibits the reaction [Hypochlorous Acid results in decreased activity of HK1 protein]

NCBI chr10:62,104,634...62,215,699
Ensembl chr10:62,104,634...62,215,687

G

hexokinase 2

decreases expression
multiple interactions

Curcumin results in decreased expression of HK2 protein
4,6-dimorpholino-N-(4-nitrophenyl)-1,3,5-triazin-2-amine inhibits the reaction [Curcumin results in decreased expression of HK2 protein]; ATF4 inhibits the reaction [Curcumin results in decreased expression of HK2 protein]; Curcumin promotes the reaction [Sirolimus results in decreased expression of HK2 protein]

NCBI chr 6:82,702,004...82,751,437
Ensembl chr 6:82,702,006...82,751,435

G

high mobility group box 1

multiple interactions

2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of HMGB1 protein]]; Curcumin inhibits the reaction [Carbon Tetrachloride affects the localization of and affects the secretion of HMGB1 protein]; Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of HMGB1 mRNA]; Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of HMGB1 protein]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of HMGB1 protein]

PMID:22683883 PMID:29480285

NCBI chr 5:148,983,512...148,989,867
Ensembl chr 5:148,983,512...149,121,299

G

3-hydroxy-3-methylglutaryl-Coenzyme A reductase

increases expression
multiple interactions
decreases expression
affects expression

Curcumin results in increased expression of HMGCR mRNA
Curcumin inhibits the reaction [bisphenol A results in increased expression of HMGCR protein]
Curcumin results in decreased expression of HMGCR mRNA
Curcumin affects the expression of HMGCR mRNA; Curcumin affects the expression of HMGCR protein

PMID:16713233 PMID:27208389 PMID:37701206

NCBI chr13:96,785,470...96,807,444
Ensembl chr13:96,785,475...96,807,444

G

3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1

decreases expression

Curcumin results in decreased expression of HMGCS1 mRNA

NCBI chr13:120,151,887...120,169,796
Ensembl chr13:120,151,915...120,169,796

G

heme oxygenase 1

multiple interactions
decreases expression
increases expression
decreases response to substance
increases activity

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Curcumin results in increased expression of HMOX1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Curcumin results in increased expression of HMOX1 protein]; [Curcumin inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]] which results in increased expression of HMOX1 protein; Acetylcysteine inhibits the reaction [Curcumin results in increased expression of HMOX1 protein]; Curcumin inhibits the reaction [Hydrogen Peroxide results in decreased expression of HMOX1 mRNA]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of HMOX1 mRNA]; Curcumin promotes the reaction [Furazolidone results in increased expression of HMOX1 protein]; Curcumin promotes the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of HMOX1 mRNA]; Curcumin promotes the reaction [quinocetone results in increased activity of HMOX1 protein]; Curcumin promotes the reaction [quinocetone results in increased expression of HMOX1 mRNA]; Curcumin promotes the reaction [sodium arsenite results in increased expression of HMOX1 protein]; Curcumin results in increased expression of and results in increased activity of HMOX1 protein; Cycloheximide inhibits the reaction [Curcumin results in increased expression of HMOX1 protein]; Dactinomycin inhibits the reaction [Curcumin results in increased expression of HMOX1 protein]; Egtazic Acid inhibits the reaction [Curcumin results in increased expression of HMOX1 protein]; Go 6976 inhibits the reaction [Curcumin results in increased expression of HMOX1 protein]; Hemin promotes the reaction [Curcumin results in increased expression of HMOX1 mRNA]; MAPK14 protein affects the reaction [Curcumin results in increased expression of HMOX1 protein]; NFE2L2 mutant form inhibits the reaction [Curcumin analog results in increased expression of HMOX1 mRNA]; NFE2L2 mutant form inhibits the reaction [Curcumin analog results in increased expression of HMOX1 protein]; NFE2L2 mutant form inhibits the reaction [Curcumin results in increased expression of HMOX1 mRNA]; NFE2L2 mutant form inhibits the reaction [Curcumin results in increased expression of HMOX1 protein]; NFE2L2 protein affects the reaction [Curcumin promotes the reaction [sodium arsenite results in increased expression of HMOX1 protein]]; PRKCA protein affects the reaction [Curcumin results in increased expression of HMOX1 protein]; PRKCD protein affects the reaction [Curcumin results in increased expression of HMOX1 protein]; Ro 31-8220 inhibits the reaction [Curcumin results in increased expression of HMOX1 protein]; rottlerin inhibits the reaction [Curcumin results in increased expression of HMOX1 protein]; SB 203580 inhibits the reaction [Curcumin results in increased expression of HMOX1 protein]; tin protoporphyrin IX inhibits the reaction [Curcumin results in increased activity of HMOX1 protein]
Curcumin results in decreased expression of HMOX1 mRNA
Curcumin analog results in increased expression of HMOX1 mRNA; Curcumin analog results in increased expression of HMOX1 protein; Curcumin results in increased expression of HMOX1 mRNA; Curcumin results in increased expression of HMOX1 protein
[chromium mesoporphyrin inhibits the reaction [Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 protein]]] which results in increased expression of HMOX1 protein; [Curcumin co-treated with Chloranil] results in increased expression of HMOX1 protein; [Curcumin co-treated with piperine] results in increased expression of HMOX1 mRNA; [Curcumin co-treated with piperine] results in increased expression of HMOX1 protein; [Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 protein]] which results in increased expression of HMOX1 protein; Acetylcysteine inhibits the reaction [[Curcumin co-treated with piperine] results in increased expression of HMOX1 protein]; AKT1 protein affects the reaction [Curcumin results in increased expression of HMOX1 mRNA]; Curcumin inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of HMOX1 protein]; Curcumin inhibits the reaction [Aflatoxin B1 results in decreased expression of HMOX1 mRNA]; Curcumin inhibits the reaction [deoxynivalenol results in decreased expression of HMOX1 mRNA]; Curcumin promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of HMOX1 mRNA]; Curcumin promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of HMOX1 protein]; Curcumin promotes the reaction [sodium arsenite results in increased expression of HMOX1 protein]; Curcumin results in increased expression of and results in increased activity of HMOX1 protein; KEAP1 protein inhibits the reaction [Curcumin results in increased expression of HMOX1 mRNA]; NFE2L2 gene mutant form affects the reaction [Curcumin promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of HMOX1 protein]]; NFE2L2 gene mutant form inhibits the reaction [Curcumin promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of HMOX1 mRNA]]; NFE2L2 gene mutant form inhibits the reaction [Curcumin results in increased expression of HMOX1 mRNA]; NFE2L2 gene mutant form inhibits the reaction [Curcumin results in increased expression of HMOX1 protein]; NFE2L2 protein affects the reaction [Curcumin results in increased expression of HMOX1 mRNA]; Wortmannin inhibits the reaction [Curcumin results in increased expression of HMOX1 mRNA]; Wortmannin inhibits the reaction [Curcumin results in increased expression of HMOX1 protein]
Curcumin analog results in increased expression of HMOX1 mRNA; Curcumin analog results in increased expression of HMOX1 protein; Curcumin results in increased expression of HMOX1; Curcumin results in increased expression of HMOX1 mRNA; Curcumin results in increased expression of HMOX1 protein
HMOX1 protein results in decreased susceptibility to Curcumin
2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [Curcumin inhibits the reaction [Lipopolysaccharides results in decreased expression of HMOX1 protein]]; [Curcumin co-treated with Fructose] results in increased expression of HMOX1 protein; [Sitagliptin Phosphate co-treated with Curcumin] inhibits the reaction [decamethrin results in decreased expression of HMOX1 protein]; Curcumin inhibits the reaction [Acetaminophen results in decreased expression of HMOX1 protein]; Curcumin inhibits the reaction [aristolochic acid I results in decreased expression of HMOX1 mRNA]; Curcumin inhibits the reaction [aristolochic acid I results in decreased expression of HMOX1 protein]; Curcumin inhibits the reaction [Atrazine results in increased activity of HMOX1 protein]; Curcumin inhibits the reaction [decamethrin results in decreased expression of HMOX1 protein]; Curcumin inhibits the reaction [Ethanol results in decreased activity of HMOX1 protein]; Curcumin inhibits the reaction [Ketamine results in decreased expression of HMOX1 mRNA]; Curcumin inhibits the reaction [Ketamine results in decreased expression of HMOX1 protein]; Curcumin inhibits the reaction [Lipopolysaccharides results in decreased expression of HMOX1 protein]; Curcumin inhibits the reaction [Paraquat results in increased activity of HMOX1 protein]; Curcumin inhibits the reaction [sodium arsenite results in decreased expression of HMOX1 protein]; Curcumin inhibits the reaction [Streptozocin results in decreased expression of HMOX1 protein]; Curcumin inhibits the reaction [Thioacetamide results in decreased expression of HMOX1 mRNA]; Curcumin promotes the reaction [[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of HMOX1 mRNA]; Curcumin promotes the reaction [[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of HMOX1 protein]; Curcumin promotes the reaction [Diethylhexyl Phthalate results in increased expression of HMOX1 mRNA]; Curcumin promotes the reaction [NFE2L2 protein binds to HMOX1 enhancer]; Curcumin promotes the reaction [Sildenafil Citrate results in increased expression of HMOX1 mRNA]; Curcumin promotes the reaction [Sildenafil Citrate results in increased expression of HMOX1 protein]; Curcumin results in increased expression of and results in increased activity of HMOX1 protein; pomegranate fruit rind promotes the reaction [Curcumin inhibits the reaction [Thioacetamide results in decreased expression of HMOX1 mRNA]]; Quartz promotes the reaction [Curcumin results in increased expression of HMOX1 mRNA]; tin protoporphyrin IX inhibits the reaction [Curcumin results in increased activity of HMOX1 protein]

PMID:10925121 PMID:14742295 PMID:17464175 PMID:17535857 PMID:17627722 More...

NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217

G

heterogeneous nuclear ribonucleoprotein A1

decreases expression

Curcumin results in decreased expression of HNRNPA1 mRNA

NCBI chr15:103,148,840...103,155,119
Ensembl chr15:103,148,859...103,155,119

G

heterogeneous nuclear ribonucleoprotein D

decreases expression

Curcumin results in decreased expression of HNRNPD mRNA

NCBI chr 5:100,103,794...100,126,926
Ensembl chr 5:100,103,794...100,126,797

G

HOP homeobox

increases expression

Curcumin results in increased expression of HOPX mRNA

NCBI chr 5:77,234,831...77,262,970
Ensembl chr 5:77,234,835...77,262,968

G

homeobox B5

increases expression

Curcumin results in increased expression of HOXB5 mRNA

NCBI chr11:96,194,338...96,196,947
Ensembl chr11:96,194,162...96,196,947

G

hypoxanthine phosphoribosyltransferase 1

increases expression

Curcumin results in increased expression of HPRT1 mRNA

NCBI chr X:52,076,955...52,110,537
Ensembl chr X:52,077,014...52,110,536

G

heat shock factor 1

multiple interactions

Curcumin promotes the reaction [HSF1 protein binds to HSF1 protein]
[arsenite co-treated with Curcumin] results in increased phosphorylation of HSF1 protein

PMID:9764755 PMID:11322385

NCBI chr15:76,361,562...76,385,355
Ensembl chr15:76,361,622...76,386,113

G

heat shock protein 90, alpha (cytosolic), class A member 1

decreases expression

Curcumin analog results in decreased expression of HSP90AA1 mRNA

NCBI chr12:110,657,470...110,662,829
Ensembl chr12:110,657,039...110,669,162

G

heat shock protein 90 alpha (cytosolic), class B member 1

multiple interactions

Curcumin promotes the reaction [Diethylhexyl Phthalate results in increased expression of HSP90AB1 mRNA]

NCBI chr17:45,878,704...45,884,187
Ensembl chr17:45,878,701...45,884,197

G

heat shock protein 90, beta (Grp94), member 1

decreases expression

Curcumin analog results in decreased expression of HSP90B1 mRNA

NCBI chr10:86,526,705...86,541,308
Ensembl chr10:86,526,073...86,541,373

G

heat shock protein 1A

increases expression
multiple interactions
decreases expression

Curcumin results in increased expression of HSPA1A mRNA; Curcumin results in increased expression of HSPA1A protein
Curcumin promotes the reaction [Diethylhexyl Phthalate results in increased expression of HSPA1A mRNA]
Curcumin results in decreased expression of HSPA1A protein

PMID:23555722 PMID:26361869

NCBI chr17:35,188,335...35,191,132
Ensembl chr17:35,188,166...35,191,132

G

heat shock protein 4

increases expression

Curcumin results in increased expression of HSPA4 mRNA; Curcumin results in increased expression of HSPA4 protein

NCBI chr11:53,150,641...53,191,306
Ensembl chr11:53,150,641...53,191,284

G

heat shock protein 5

increases expression
decreases expression
multiple interactions

Curcumin results in increased expression of HSPA5 mRNA
Curcumin results in decreased expression of HSPA5 protein
4-phenylbutyric acid inhibits the reaction [Curcumin results in decreased expression of HSPA5 protein]; Curcumin inhibits the reaction [Furazolidone results in increased expression of HSPA5 protein]; Curcumin inhibits the reaction [Tunicamycin results in increased expression of HSPA5 protein]

PMID:18200517 PMID:27996348 PMID:29723631 PMID:36640941

NCBI chr 2:34,662,102...34,666,541
Ensembl chr 2:34,661,982...34,667,559

G

heat shock protein 1

multiple interactions

Curcumin inhibits the reaction [Streptozocin results in increased expression of HSPB1 protein]; Curcumin promotes the reaction [Isoproterenol results in increased expression of HSPB1 protein]

PMID:18204486 PMID:20125031

NCBI chr 5:135,916,773...135,918,417
Ensembl chr 5:135,916,773...135,918,417

G

heat shock protein family, member 7 (cardiovascular)

multiple interactions

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of HSPB7 mRNA]

NCBI chr 4:141,148,090...141,152,621
Ensembl chr 4:141,148,090...141,152,622

G

heat shock protein 1 (chaperonin)

multiple interactions

Curcumin promotes the reaction [Diethylhexyl Phthalate results in increased expression of HSPD1 mRNA]
[arsenic trioxide co-treated with Curcumin] results in increased expression of HSPD1 protein

PMID:26361869 PMID:27430728

NCBI chr 1:55,116,992...55,127,402
Ensembl chr 1:55,116,994...55,127,402

G

5-hydroxytryptamine (serotonin) receptor 1A

affects expression

Curcumin affects the expression of HTR1A mRNA

NCBI chr13:105,580,040...105,584,630
Ensembl chr13:105,580,147...105,584,630

G

intercellular adhesion molecule 1

multiple interactions
decreases expression
affects expression

[Curcumin inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]] which results in increased expression of HMOX1 protein; chromium mesoporphyrin inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]]; Curcumin inhibits the reaction [Paclitaxel results in increased expression of ICAM1 protein]; Curcumin inhibits the reaction [Particulate Matter results in increased expression of ICAM1 protein]; Curcumin inhibits the reaction [titanium dioxide results in increased expression of ICAM1 protein]; Curcumin inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]
Curcumin analog inhibits the reaction [Glucose results in increased expression of ICAM1 mRNA]; Curcumin inhibits the reaction [Glucose results in increased expression of ICAM1 mRNA]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 mRNA]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 protein]; Curcumin inhibits the reaction [Methotrexate results in increased expression of ICAM1 mRNA]; ICAM1 protein affects the reaction [Curcumin affects the reaction [Lipopolysaccharides affects the expression of IL10 protein]]; ICAM1 protein affects the reaction [Curcumin affects the reaction [Lipopolysaccharides affects the expression of IL6 protein]]; ICAM1 protein affects the reaction [Curcumin affects the reaction [Lipopolysaccharides affects the expression of TNF protein]]; ICAM1 protein affects the reaction [Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of CDH2 protein]]; ICAM1 protein affects the reaction [Curcumin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein]]; ICAM1 protein affects the reaction [Curcumin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of RELA protein]]
[chromium mesoporphyrin inhibits the reaction [Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 protein]]] which results in increased expression of HMOX1 protein; [Curcumin co-treated with Gemcitabine] results in decreased expression of ICAM1 protein; [Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 protein]] which results in increased expression of HMOX1 protein; chromium mesoporphyrin inhibits the reaction [Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 protein]]; Curcumin analog inhibits the reaction [Streptozocin results in increased expression of ICAM1 mRNA]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 protein]; Curcumin inhibits the reaction [Streptozocin results in increased expression of ICAM1 mRNA]; Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of ICAM1 mRNA]
Curcumin results in decreased expression of ICAM1 protein
Curcumin affects the expression of ICAM1 mRNA

PMID:16219905 PMID:16243823 PMID:17440100 PMID:17666914 PMID:17973899 More...

NCBI chr 9:20,927,236...20,940,110
Ensembl chr 9:20,927,281...20,940,113

G

inhibitor of DNA binding 1, HLH protein

decreases expression

Curcumin results in decreased expression of ID1 mRNA

NCBI chr 2:152,578,171...152,579,330
Ensembl chr 2:152,578,171...152,579,330

G

inhibitor of DNA binding 2

decreases expression

Curcumin results in decreased expression of ID2 mRNA

NCBI chr12:25,143,798...25,146,091
Ensembl chr12:25,143,798...25,147,139

G

inhibitor of DNA binding 3

decreases expression

Curcumin results in decreased expression of ID3 mRNA

NCBI chr 4:135,871,133...135,872,703
Ensembl chr 4:135,870,808...135,873,066

G

indoleamine 2,3-dioxygenase 1

decreases expression

Curcumin results in decreased expression of IDO1 mRNA

NCBI chr 8:25,074,148...25,086,987
Ensembl chr 8:25,074,152...25,087,025

G

interferon alpha 1

multiple interactions

Curcumin inhibits the reaction [IFNA1 protein results in increased expression of IFNAR2 protein]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of IFNA1 mRNA]; Curcumin promotes the reaction [IFNA1 protein results in increased expression of IFNAR1 protein]; Curcumin promotes the reaction [IFNA1 protein results in increased expression of IL10 protein]

PMID:17979888 PMID:23452621

NCBI chr 4:88,768,324...88,768,893
Ensembl chr 4:88,768,324...88,768,893

G

interferon (alpha and beta) receptor 1

multiple interactions

Curcumin promotes the reaction [IFNA1 protein results in increased expression of IFNAR1 protein]; Curcumin promotes the reaction [IFNB1 protein results in increased expression of IFNAR1 protein]

NCBI chr16:91,281,016...91,307,411
Ensembl chr16:91,282,126...91,304,329

G

interferon (alpha and beta) receptor 2

multiple interactions

Curcumin inhibits the reaction [IFNA1 protein results in increased expression of IFNAR2 protein]; Curcumin promotes the reaction [IFNB1 protein results in increased expression of IFNAR2 protein]

NCBI chr16:91,166,517...91,202,477
Ensembl chr16:91,169,671...91,202,477

G

interferon beta 1, fibroblast

multiple interactions

Curcumin promotes the reaction [IFNB1 protein results in increased expression of IFNAR1 protein]; Curcumin promotes the reaction [IFNB1 protein results in increased expression of IFNAR2 protein]; Curcumin promotes the reaction [IFNB1 protein results in increased expression of IL10 protein]; Curcumin promotes the reaction [IFNB1 protein results in increased phosphorylation of STAT4 protein]

NCBI chr 4:88,440,253...88,441,083
Ensembl chr 4:88,440,262...88,441,011

G

interferon gamma

multiple interactions
increases secretion

Curcumin inhibits the reaction [IFNG protein results in increased expression of and results in increased phosphorylation of STAT1 protein]; Curcumin inhibits the reaction [IFNG protein results in increased expression of and results in increased phosphorylation of STAT3 protein]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of IFNG mRNA]
[Curcumin co-treated with piperine] inhibits the reaction [IFNG protein results in increased abundance of Nitrites]; Curcumin inhibits the reaction [sodium arsenite affects the expression of IFNG mRNA]; tin protoporphyrin IX inhibits the reaction [[Curcumin co-treated with piperine] inhibits the reaction [IFNG protein results in increased abundance of Nitrites]]
Curcumin results in increased secretion of IFNG protein
Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of IFNG protein]; Curcumin inhibits the reaction [Doxorubicin results in increased expression of IFNG protein]; Curcumin inhibits the reaction [Streptozocin results in decreased expression of IFNG protein]; Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IFNG mRNA]; Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IFNG protein]

PMID:16782535 PMID:16867261 PMID:16959222 PMID:18006644 PMID:22714040 More...

NCBI chr10:118,276,951...118,281,799
Ensembl chr10:118,276,951...118,281,797

G

interferon kappa

decreases expression

Curcumin results in decreased expression of IFNK mRNA

NCBI chr 4:35,152,055...35,154,019
Ensembl chr 4:35,152,056...35,154,005

G

insulin-like growth factor 1

decreases activity
multiple interactions
decreases expression
decreases secretion

Curcumin results in decreased activity of IGF1 protein
Curcumin inhibits the reaction [[IGF1 protein co-treated with Estradiol] results in increased expression of JUN protein]; Curcumin inhibits the reaction [IGF1 protein results in increased activity of IGF1R protein]
Curcumin analog results in decreased expression of IGF1 mRNA
Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IGF1 mRNA]
Curcumin results in decreased secretion of IGF1 protein

PMID:17458902 PMID:17499312 PMID:18200517 PMID:26409325

NCBI chr10:87,694,127...87,772,909
Ensembl chr10:87,694,127...87,772,904

G

insulin-like growth factor I receptor

multiple interactions
decreases expression

Curcumin inhibits the reaction [IGF1 protein results in increased activity of IGF1R protein]; Curcumin promotes the reaction [Folfox protocol results in decreased phosphorylation of and results in decreased activity of IGF1R protein]; Curcumin results in decreased phosphorylation of and results in decreased activity of IGF1R protein; Fluorouracil promotes the reaction [Curcumin results in decreased phosphorylation of and results in decreased activity of IGF1R protein]
Curcumin analog results in decreased expression of IGF1R mRNA; Curcumin results in decreased expression of IGF1R mRNA

PMID:17499312 PMID:17918158 PMID:26409325

NCBI chr 7:67,601,486...67,883,416
Ensembl chr 7:67,602,575...67,883,416

G

insulin-like growth factor 2

decreases expression
multiple interactions

Curcumin analog results in decreased expression of IGF2 mRNA
[arsenic trioxide co-treated with Curcumin] results in increased expression of IGF2 protein

PMID:26409325 PMID:27430728

NCBI chr 7:142,204,505...142,220,566
Ensembl chr 7:142,204,503...142,220,553

G

insulin-like growth factor binding protein 1

multiple interactions

[arsenic trioxide co-treated with Curcumin] results in decreased expression of IGFBP1 protein

NCBI chr11:7,147,787...7,152,546
Ensembl chr11:7,147,782...7,152,546

G

insulin-like growth factor binding protein 2

multiple interactions

[arsenic trioxide co-treated with Curcumin] results in decreased expression of IGFBP2 protein

NCBI chr 1:72,863,650...72,891,633
Ensembl chr 1:72,863,662...72,891,633

G

insulin-like growth factor binding protein 3

decreases expression
multiple interactions
increases secretion
increases expression

Curcumin results in decreased expression of IGFBP3 mRNA
[arsenic trioxide co-treated with Curcumin] results in increased expression of IGFBP3 protein
Curcumin results in increased secretion of IGFBP3 protein
Curcumin results in increased expression of IGFBP3 mRNA

PMID:16101141 PMID:17499312 PMID:18299980 PMID:21594647 PMID:27430728

NCBI chr11:7,156,086...7,165,498
Ensembl chr11:7,156,086...7,163,923

G

insulin-like growth factor binding protein 4

multiple interactions

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IGFBP4 mRNA]
[arsenic trioxide co-treated with Curcumin] results in increased expression of IGFBP4 protein

PMID:18200517 PMID:27430728

NCBI chr11:98,930,820...98,943,481
Ensembl chr11:98,932,070...98,945,218

G

insulin-like growth factor binding protein 5

multiple interactions

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IGFBP5 mRNA]
[arsenic trioxide co-treated with Curcumin] results in increased expression of IGFBP5 protein

PMID:18200517 PMID:27430728

NCBI chr 1:72,897,224...72,914,024
Ensembl chr 1:72,897,091...72,914,043

G

insulin-like growth factor binding protein 7

increases expression

Curcumin results in increased expression of IGFBP7 mRNA

NCBI chr 5:77,497,092...77,555,892
Ensembl chr 5:77,497,087...77,555,888

G

immunoglobulin lambda-like polypeptide 1

decreases expression

Curcumin results in decreased expression of IGLL1 mRNA

NCBI chr16:16,678,535...16,681,849
Ensembl chr16:16,678,535...16,681,849

G

inhibitor of kappaB kinase beta

multiple interactions
decreases activity

Curcumin inhibits the reaction [bisphenol A results in increased expression of IKBKB protein modified form]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of IKBKB mRNA]; Curcumin inhibits the reaction [TNF protein results in increased activity of IKBKB protein]; IKBKB protein inhibits the reaction [Curcumin results in decreased expression of CCN2 mRNA]
Curcumin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of IKBKB protein]
Curcumin results in decreased activity of IKBKB protein

PMID:16023083 PMID:16219905 PMID:16678799 PMID:17965732 PMID:20054000 More...

NCBI chr 8:23,149,228...23,196,605
Ensembl chr 8:23,149,228...23,196,605

G

inhibitor of kappaB kinase gamma

multiple interactions

Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of IKBKG mRNA]

NCBI chr X:73,436,883...73,498,013
Ensembl chr X:73,436,896...73,497,460

G

interleukin 10

multiple interactions
decreases expression

Curcumin inhibits the reaction [nickel chloride results in increased expression of IL10 protein]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of IL10 mRNA]; Curcumin promotes the reaction [IFNA1 protein results in increased expression of IL10 protein]; Curcumin promotes the reaction [IFNB1 protein results in increased expression of IL10 protein]
Curcumin results in decreased expression of IL10 protein
CD40 protein affects the reaction [Curcumin affects the reaction [Lipopolysaccharides affects the expression of IL10 protein]]; Curcumin affects the reaction [Lipopolysaccharides affects the expression of IL10 protein]; Curcumin analog inhibits the reaction [Copper Sulfate results in decreased secretion of IL10 protein]; Curcumin inhibits the reaction [Copper Sulfate results in decreased secretion of IL10 protein]; Curcumin inhibits the reaction [Methotrexate results in decreased secretion of IL10 protein]; Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of IL10 mRNA]; ICAM1 protein affects the reaction [Curcumin affects the reaction [Lipopolysaccharides affects the expression of IL10 protein]]

PMID:15604057 PMID:16867261 PMID:17979888 PMID:20885979 PMID:21397623 More...

NCBI chr 1:130,947,459...130,952,707
Ensembl chr 1:130,947,582...130,952,711

G

interleukin 12a

multiple interactions

Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of IL12A mRNA]

NCBI chr 3:68,597,977...68,605,881
Ensembl chr 3:68,597,977...68,605,880

G

interleukin 12b

multiple interactions

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL12B mRNA]
Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of IL12B mRNA]

PMID:16867261 PMID:23452621

NCBI chr11:44,290,890...44,305,504
Ensembl chr11:44,290,890...44,304,860

G

interleukin 17A

multiple interactions

Curcumin inhibits the reaction [[Ovalbumin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of IL17A protein]; Curcumin inhibits the reaction [Bleomycin results in increased expression of IL17A mRNA]

PMID:34998855 PMID:35716765

NCBI chr 1:20,801,129...20,804,720
Ensembl chr 1:20,801,129...20,804,720

G

interleukin 18

multiple interactions
decreases expression

Curcumin inhibits the reaction [IL18 protein results in increased expression of VEGFA mRNA]; Curcumin inhibits the reaction [IL18 protein results in increased expression of VEGFA protein]; Curcumin inhibits the reaction [Lipopolysaccharides promotes the reaction [NFKB1 protein binds to IL18 promoter]]; Curcumin inhibits the reaction [Lipopolysaccharides promotes the reaction [RELA protein binds to IL18 promoter]]
Curcumin inhibits the reaction [Aflatoxin B1 results in increased expression of IL18 mRNA]; Curcumin inhibits the reaction [Aflatoxin B1 results in increased secretion of IL18 protein]
Curcumin results in decreased expression of IL18 mRNA
Curcumin results in decreased expression of IL18 mRNA; Curcumin results in decreased expression of IL18 protein

PMID:16368150 PMID:16751071 PMID:17399992 PMID:35063475

NCBI chr 9:50,466,000...50,493,141
Ensembl chr 9:50,466,127...50,493,140

G

interleukin 1 alpha

multiple interactions

Curcumin inhibits the reaction [IL1A protein results in increased expression of TNFSF11 protein]
Curcumin inhibits the reaction [Soot results in increased secretion of IL1A protein]

PMID:18719352 PMID:19782127

NCBI chr 2:129,141,530...129,151,892
Ensembl chr 2:129,141,530...129,151,892

G

interleukin 1 beta

affects expression
multiple interactions
decreases expression

Curcumin affects the expression of IL1B mRNA
Curcumin inhibits the reaction [[TNF protein co-treated with IL1B protein] results in increased expression of CXCL8 mRNA]; Curcumin inhibits the reaction [[TNF protein co-treated with IL1B protein] results in increased expression of IL6 mRNA]; Curcumin inhibits the reaction [[TNF protein co-treated with IL1B protein] results in increased expression of PTGS2 protein]; Curcumin inhibits the reaction [[TNF protein co-treated with IL1B protein] results in increased phosphorylation of MAPK14 protein]; Curcumin inhibits the reaction [IL1B protein promotes the reaction [Shiga Toxin binds to globotriaosylceramide]]; Curcumin inhibits the reaction [IL1B protein results in decreased expression of GSK3B mRNA]; Curcumin inhibits the reaction [IL1B protein results in decreased expression of ITGB1 protein]; Curcumin inhibits the reaction [IL1B protein results in increased degradation of NFKBIA protein]; Curcumin inhibits the reaction [IL1B protein results in increased expression of A4GALT mRNA]; Curcumin inhibits the reaction [IL1B protein results in increased expression of CTNNB1 protein]; Curcumin inhibits the reaction [IL1B protein results in increased expression of CXCL8 mRNA]; Curcumin inhibits the reaction [IL1B protein results in increased expression of GSK3B protein]; Curcumin inhibits the reaction [IL1B protein results in increased expression of MMP9 protein]; Curcumin inhibits the reaction [IL1B protein results in increased expression of PTGES protein]; Curcumin inhibits the reaction [IL1B protein results in increased expression of PTGS2 protein]; Curcumin inhibits the reaction [IL1B protein results in increased localization of RELA protein]; Curcumin inhibits the reaction [IL1B protein results in increased phosphorylation of and results in increased activity of AKT1 protein]; Curcumin inhibits the reaction [IL1B protein results in increased phosphorylation of and results in increased activity of and results in increased localization of RELA protein]; Curcumin inhibits the reaction [IL1B protein results in increased phosphorylation of NFKBIA protein]; Curcumin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of IL1B protein]; Curcumin inhibits the reaction [nickel chloride results in increased expression of IL1B protein]; Curcumin inhibits the reaction [TNF protein results in decreased expression of IL1B mRNA]
[Dexamethasone co-treated with Curcumin] inhibits the reaction [[Ovalbumin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of IL1B mRNA]; [Dexamethasone co-treated with Curcumin] inhibits the reaction [[Ovalbumin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of IL1B protein]; Curcumin analog inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]; Curcumin inhibits the reaction [[Ovalbumin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of IL1B mRNA]; Curcumin inhibits the reaction [[Ovalbumin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of IL1B protein]; Curcumin inhibits the reaction [Aflatoxin B1 results in increased expression of IL1B mRNA]; Curcumin inhibits the reaction [Aflatoxin B1 results in increased secretion of IL1B protein]; Curcumin inhibits the reaction [Chloranil results in increased expression of IL1B protein]; Curcumin inhibits the reaction [deoxynivalenol results in increased expression of IL1B mRNA]; Curcumin inhibits the reaction [Dibutyl Phthalate results in increased expression of IL1B protein]; Curcumin inhibits the reaction [IL1B protein results in increased expression of MMP1 mRNA]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; Curcumin inhibits the reaction [sodium arsenite results in increased expression of IL1B mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of IL1B mRNA]; Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL1B mRNA]; NFE2L2 gene mutant form inhibits the reaction [Curcumin results in decreased expression of IL1B mRNA]
[Sitagliptin Phosphate co-treated with Curcumin] inhibits the reaction [decamethrin results in increased expression of IL1B protein]; Curcumin analog inhibits the reaction [Monocrotaline results in increased expression of IL1B protein]; Curcumin inhibits the reaction [[boldenone undecylenate results in increased abundance of boldenone] which results in increased expression of IL1B mRNA]; Curcumin inhibits the reaction [[TNF protein co-treated with IL1B protein] results in increased secretion of CXCL2 protein]; Curcumin inhibits the reaction [Acetaminophen results in increased expression of IL1B mRNA]; Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of IL1B mRNA]; Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of IL1B protein]; Curcumin inhibits the reaction [decamethrin results in increased expression of IL1B protein]; Curcumin inhibits the reaction [Doxorubicin results in increased expression of IL1B protein]; Curcumin inhibits the reaction [Ethanol results in increased expression of IL1B mRNA]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; Curcumin inhibits the reaction [Soot results in increased secretion of IL1B protein]; Curcumin inhibits the reaction [Streptozocin results in decreased expression of IL1B protein]; Curcumin inhibits the reaction [Thioacetamide results in increased expression of IL1B protein]; Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL1B mRNA]; pomegranate fruit rind promotes the reaction [Curcumin inhibits the reaction [Thioacetamide results in increased expression of IL1B protein]]

PMID:15604057 PMID:15793857 PMID:16751071 PMID:16782535 PMID:16819191 More...

NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059

G

interleukin 2

multiple interactions

Curcumin results in decreased expression of and results in decreased secretion of IL2 protein

NCBI chr 3:37,174,862...37,180,103
Ensembl chr 3:37,174,672...37,180,108

G

interleukin 2 receptor, alpha chain

multiple interactions

Curcumin inhibits the reaction [Carbon Tetrachloride results in decreased expression of IL2RA protein]

NCBI chr 2:11,647,603...11,698,005
Ensembl chr 2:11,647,618...11,698,004

G

interleukin 4

multiple interactions
decreases expression

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of IL4 mRNA]; Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of IL4 protein]
Curcumin results in decreased expression of IL4 protein

PMID:16782535 PMID:16867261 PMID:21397623

NCBI chr11:53,503,287...53,509,492
Ensembl chr11:53,493,809...53,509,496

G

interleukin 5

multiple interactions

[Dexamethasone co-treated with Curcumin] inhibits the reaction [[Ovalbumin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of IL5 protein]; Curcumin inhibits the reaction [[Ovalbumin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of IL5 protein]

NCBI chr11:53,611,621...53,615,930
Ensembl chr11:53,611,621...53,615,933

G

interleukin 6

multiple interactions
decreases expression
increases expression
affects expression

Curcumin inhibits the reaction [[benz(a)anthracene co-treated with TNF protein] results in increased expression of IL6 mRNA]; Curcumin inhibits the reaction [[TNF protein co-treated with IL1B protein] results in increased expression of IL6 mRNA]; Curcumin inhibits the reaction [Acids results in increased expression of IL6 mRNA]; Curcumin inhibits the reaction [Acids results in increased secretion of IL6 protein]; Curcumin inhibits the reaction [bisphenol A results in increased expression of IL6 mRNA]; Curcumin inhibits the reaction [bisphenol A results in increased expression of IL6 protein]; Curcumin inhibits the reaction [cadmium sulfate results in increased expression of IL6 mRNA]; Curcumin inhibits the reaction [cadmium sulfate results in increased secretion of IL6 protein]; Curcumin inhibits the reaction [IL6 protein results in increased expression of AR mRNA]; Curcumin inhibits the reaction [IL6 protein results in increased expression of AR protein]; Curcumin inhibits the reaction [IL6 protein results in increased expression of KLK3 mRNA]; Curcumin inhibits the reaction [IL6 protein results in increased expression of KLK3 protein]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]; Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of IL6 protein]; Curcumin inhibits the reaction [nickel chloride results in increased expression of IL6 protein]; Curcumin inhibits the reaction [TNF protein results in decreased expression of IL6 mRNA]; MIR125A mRNA inhibits the reaction [Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of IL6 protein]]; SIRT6 protein promotes the reaction [Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of IL6 protein]]; tin protoporphyrin IX inhibits the reaction [Curcumin inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]]
[Curcumin co-treated with Niacin co-treated with ZM 241385] inhibits the reaction [Rotenone results in increased expression of IL6 protein]; Curcumin analog inhibits the reaction [Streptozocin results in increased expression of IL6 mRNA]; Curcumin inhibits the reaction [Bleomycin results in increased expression of IL6 mRNA]; Curcumin inhibits the reaction [Bleomycin results in increased expression of IL6 protein]; Curcumin inhibits the reaction [Chloranil results in increased expression of IL6 protein]; Curcumin inhibits the reaction [deoxynivalenol results in increased expression of IL6 mRNA]; Curcumin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL6 mRNA]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]; Curcumin inhibits the reaction [Rotenone results in increased expression of IL6 protein]; Curcumin inhibits the reaction [sodium arsenite affects the expression of IL6 mRNA]; Curcumin inhibits the reaction [Streptozocin results in increased expression of IL6 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of IL6 mRNA]; Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL6 mRNA]; NFE2L2 gene mutant form inhibits the reaction [Curcumin results in decreased expression of IL6 mRNA]
Curcumin results in increased expression of IL6 protein
Curcumin results in increased expression of IL6 mRNA
2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]]; [Sitagliptin Phosphate co-treated with Curcumin] inhibits the reaction [decamethrin results in increased expression of IL6 protein]; [Zinc binds to Curcumin] inhibits the reaction [Ethanol results in increased expression of IL6 mRNA]; CD40 protein affects the reaction [Curcumin affects the reaction [Lipopolysaccharides affects the expression of IL6 protein]]; Curcumin affects the reaction [Lipopolysaccharides affects the expression of IL6 protein]; Curcumin analog inhibits the reaction [Glucose results in increased expression of IL6 mRNA]; Curcumin inhibits the reaction [[Copper Sulfate results in increased abundance of Copper] which results in increased expression of IL6 protein]; Curcumin inhibits the reaction [[Lipopolysaccharides co-treated with Tobacco Smoke Pollution] results in increased expression of IL6 protein]; Curcumin inhibits the reaction [Acetaminophen results in increased expression of IL6 mRNA]; Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of IL6 mRNA]; Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of IL6 protein]; Curcumin inhibits the reaction [Colistin results in increased expression of IL6 protein]; Curcumin inhibits the reaction [decamethrin results in increased expression of IL6 protein]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]; Curcumin inhibits the reaction [Rotenone results in increased expression of IL6 protein]; Curcumin inhibits the reaction [sodium arsenite results in increased expression of IL6 protein]; Curcumin inhibits the reaction [Soot results in increased secretion of IL6 protein]; Curcumin inhibits the reaction [Streptozocin results in increased expression of IL6 protein]; ICAM1 protein affects the reaction [Curcumin affects the reaction [Lipopolysaccharides affects the expression of IL6 protein]]
Curcumin affects the expression of IL6 mRNA; Curcumin affects the expression of IL6 protein

PMID:16751071 PMID:17151092 PMID:17273796 PMID:17383825 PMID:17999991 More...

NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979

G

interleukin 6 receptor, alpha

multiple interactions

Curcumin inhibits the reaction [Trichloroethylene results in increased expression of IL6R protein]

NCBI chr 3:89,776,631...89,820,503
Ensembl chr 3:89,771,366...89,820,503

G

interleukin 6 signal transducer

multiple interactions

Curcumin inhibits the reaction [Trichloroethylene results in increased expression of IL6ST protein]

NCBI chr13:112,600,604...112,643,394
Ensembl chr13:112,600,604...112,646,620

G

insulin I

multiple interactions

Curcumin inhibits the reaction [Dietary Fats results in increased expression of INS1 protein]
Curcumin inhibits the reaction [Streptozocin results in decreased expression of INS1 protein]

PMID:23267840 PMID:25541178 PMID:27208389

NCBI chr19:52,252,735...52,253,453
Ensembl chr19:52,252,735...52,253,914

G

insulin II

multiple interactions

Curcumin inhibits the reaction [Fructose results in increased expression of INS protein]
Curcumin inhibits the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased abundance of Triglycerides]; Curcumin inhibits the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of ADIPOQ mRNA]; Curcumin inhibits the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of CEBPA mRNA]; Curcumin inhibits the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of PPARG mRNA]; Curcumin inhibits the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of TNF mRNA]; Curcumin inhibits the reaction [butylbenzyl phthalate promotes the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased abundance of Triglycerides]]; Curcumin inhibits the reaction [butylbenzyl phthalate promotes the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of ADIPOQ mRNA]]; Curcumin inhibits the reaction [butylbenzyl phthalate promotes the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of CEBPA mRNA]]; Curcumin inhibits the reaction [butylbenzyl phthalate promotes the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of PPARG mRNA]]; Curcumin inhibits the reaction [butylbenzyl phthalate promotes the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of TNF mRNA]]

PMID:25268984 PMID:26713546 PMID:28595985

NCBI chr 7:142,232,393...142,233,463
Ensembl chr 7:142,232,393...142,297,118

G

insulin induced gene 2

multiple interactions

Curcumin inhibits the reaction [INSIG2 protein results in decreased expression of LDLR mRNA]

NCBI chr 1:121,232,082...121,260,391
Ensembl chr 1:121,232,082...121,260,318

G

insulin receptor

multiple interactions

Curcumin inhibits the reaction [bisphenol A results in decreased expression of INSR protein modified form]

NCBI chr 8:3,200,922...3,329,649
Ensembl chr 8:3,172,061...3,329,617

G

inositol 1,4,5-triphosphate receptor associated 2

decreases expression

Curcumin results in decreased expression of IRAG2 mRNA

NCBI chr 6:145,061,357...145,120,655
Ensembl chr 6:145,061,379...145,120,660

G

interleukin-1 receptor-associated kinase 1

multiple interactions

Curcumin inhibits the reaction [Lipopolysaccharides results in increased degradation of IRAK1 protein]
Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of IRAK1 mRNA]

PMID:16678799 PMID:23452621

NCBI chr X:73,057,520...73,067,527
Ensembl chr X:73,057,520...73,067,524

G

interleukin-1 receptor-associated kinase 2

multiple interactions

Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of IRAK2 mRNA]

NCBI chr 6:113,615,428...113,671,987
Ensembl chr 6:113,615,428...113,671,987

G

interferon regulatory factor 3

multiple interactions

Curcumin inhibits the reaction [[Lipopolysaccharides binds to TLR4 protein] which results in increased activity of IRF3 protein]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased activity of IRF3 protein]

NCBI chr 7:44,647,072...44,652,272
Ensembl chr 7:44,647,072...44,652,272

G

interferon regulatory factor 5

increases expression

Curcumin analog results in increased expression of IRF5 mRNA

NCBI chr 6:29,526,129...29,541,874
Ensembl chr 6:29,526,624...29,541,870

G

insulin receptor substrate 1

multiple interactions
affects phosphorylation

Curcumin inhibits the reaction [Fructose affects the phosphorylation of IRS1 protein]
Curcumin inhibits the reaction [bisphenol A results in increased expression of IRS1 protein modified form]
Curcumin affects the phosphorylation of IRS1 protein

PMID:26713546 PMID:27208389 PMID:29793316

NCBI chr 1:82,210,826...82,269,160
Ensembl chr 1:82,210,822...82,269,137

G

insulin receptor substrate 2

affects phosphorylation

Curcumin affects the phosphorylation of IRS2 protein

NCBI chr 8:11,034,681...11,058,929
Ensembl chr 8:11,034,681...11,058,458

G

integrin alpha 2b

multiple interactions

Curcumin inhibits the reaction [F2 protein results in increased expression of ITGA2B protein]

NCBI chr11:102,344,134...102,360,570
Ensembl chr11:102,344,123...102,360,948

G

integrin alpha M

multiple interactions
increases expression

Calcitriol promotes the reaction [Curcumin results in increased expression of ITGAM]; Tretinoin promotes the reaction [Curcumin results in increased expression of ITGAM]

NCBI chr 7:127,661,812...127,717,663
Ensembl chr 7:127,661,812...127,717,663

G

integrin beta 1 (fibronectin receptor beta)

multiple interactions
increases expression

Curcumin inhibits the reaction [IL1B protein results in decreased expression of ITGB1 protein]
Curcumin results in increased expression of ITGB1 protein

NCBI chr 8:129,412,135...129,460,060
Ensembl chr 8:129,412,135...129,459,681

G

integrin beta 3

multiple interactions

Curcumin inhibits the reaction [F2 protein results in increased expression of ITGB3 protein]

NCBI chr11:104,498,826...104,561,302
Ensembl chr11:104,498,826...104,561,302

G

integral membrane protein 2A

multiple interactions

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of ITM2A mRNA]

NCBI chr X:106,440,801...106,446,966
Ensembl chr X:106,440,705...106,446,982

G

involucrin

multiple interactions

Curcumin inhibits the reaction [MAP3K1 protein results in increased expression of IVL mRNA]; Curcumin inhibits the reaction [PRKCD protein results in increased expression of IVL mRNA]; Curcumin inhibits the reaction [PRKCE protein results in increased expression of IVL mRNA]; Curcumin inhibits the reaction [PRKCH protein results in increased expression of IVL mRNA]; Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of IVL mRNA]

NCBI chr 3:92,478,206...92,481,097
Ensembl chr 3:92,478,209...92,481,042

G

Janus kinase 2

decreases expression
multiple interactions

Curcumin results in decreased expression of JAK2 protein
Arsenic Trioxide promotes the reaction [Curcumin results in decreased expression of JAK2 protein]; Curcumin inhibits the reaction [Trichloroethylene results in increased phosphorylation of JAK2 protein]

PMID:16959222 PMID:34233590 PMID:36352148

NCBI chr19:29,229,006...29,290,495
Ensembl chr19:29,229,228...29,290,480

G

Janus kinase 3

decreases activity

Curcumin results in decreased activity of JAK3 protein

NCBI chr 8:72,129,027...72,143,221
Ensembl chr 8:72,128,940...72,143,219

G

jun proto-oncogene

decreases phosphorylation
multiple interactions
increases expression
decreases activity

Curcumin results in decreased phosphorylation of JUN protein
Curcumin inhibits the reaction [[IGF1 protein co-treated with Estradiol] results in increased expression of JUN protein]; Curcumin inhibits the reaction [benzyl isothiocyanate results in increased expression of and results in increased phosphorylation of JUN protein]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of JUN mRNA]; Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of and results in increased activity of JUN protein]; Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of JUN protein]
Curcumin inhibits the reaction [Bleomycin results in increased phosphorylation of JUN protein]; Curcumin inhibits the reaction [sodium arsenite results in increased phosphorylation of JUN protein]; Curcumin inhibits the reaction [Tobacco Smoke Pollution results in increased phosphorylation of JUN protein]
Curcumin results in increased expression of JUN mRNA
[Curcumin co-treated with Manganese] inhibits the reaction [Kainic Acid results in increased expression of JUN mRNA]; Curcumin analog inhibits the reaction [Rotenone results in increased phosphorylation of JUN protein]
Curcumin results in decreased activity of JUN protein

PMID:11035063 PMID:15713895 PMID:17148446 PMID:17458902 PMID:17596214 More...

NCBI chr 4:94,937,273...94,940,459
Ensembl chr 4:94,937,271...94,940,459

G

jun B proto-oncogene

multiple interactions
increases ubiquitination

benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of JUNB protein]]; Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate promotes the reaction [FOSL1 protein binds to JUNB protein]]; Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of JUNB protein]
Curcumin results in increased ubiquitination of JUNB protein

NCBI chr 8:85,703,538...85,705,377
Ensembl chr 8:85,701,113...85,705,347

G

jun D proto-oncogene

multiple interactions

Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of JUND protein]

NCBI chr 8:71,150,389...71,153,265
Ensembl chr 8:71,151,599...71,153,265

G

potassium voltage-gated channel, subfamily H (eag-related), member 2

decreases activity

Curcumin results in decreased activity of KCNH2 protein

NCBI chr 5:24,524,583...24,556,671
Ensembl chr 5:24,524,587...24,556,602

G

potassium large conductance calcium-activated channel, subfamily M, beta member 2

decreases expression

Curcumin results in decreased expression of KCNMB2 mRNA

NCBI chr 3:31,956,021...32,254,329
Ensembl chr 3:31,956,656...32,254,329

G

kinase insert domain protein receptor

affects expression
multiple interactions

Curcumin affects the expression of KDR mRNA
[bisdemethoxycurcumin co-treated with Curcumin co-treated with demethoxycurcumin] inhibits the reaction [VEGF protein results in increased phosphorylation of KDR protein]; Curcumin inhibits the reaction [VEGF protein results in increased phosphorylation of KDR protein]
Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of KDR mRNA]; Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of KDR protein]
Curcumin inhibits the reaction [Dietary Fats results in increased expression of KDR mRNA]

PMID:17960570 PMID:19297423 PMID:23845850 PMID:35752269

NCBI chr 5:76,093,487...76,139,880
Ensembl chr 5:76,093,487...76,139,118

G

kelch-like ECH-associated protein 1

multiple interactions
decreases expression
increases expression

Curcumin inhibits the reaction [Aflatoxin B1 results in decreased expression of KEAP1 mRNA]; Curcumin inhibits the reaction [Aflatoxin B1 results in decreased expression of KEAP1 protein]; KEAP1 protein inhibits the reaction [Curcumin results in increased expression of HMOX1 mRNA]
Curcumin inhibits the reaction [Hydrogen Peroxide results in decreased expression of KEAP1 mRNA]; Curcumin inhibits the reaction [KEAP1 protein results in increased ubiquitination of NFE2L2 protein]
Curcumin results in decreased expression of KEAP1 mRNA
Curcumin analog results in decreased expression of KEAP1 protein; Curcumin results in decreased expression of KEAP1 protein
Curcumin analog promotes the reaction [APP protein modified form results in decreased expression of KEAP1 protein]; Curcumin inhibits the reaction [aristolochic acid I results in decreased expression of KEAP1 mRNA]; Curcumin inhibits the reaction [aristolochic acid I results in decreased expression of KEAP1 protein]; Curcumin promotes the reaction [APP protein modified form results in decreased expression of KEAP1 protein]
Curcumin results in increased expression of KEAP1 mRNA

PMID:17535857 PMID:23710286 PMID:26991801 PMID:30946834 PMID:31521693 More...

NCBI chr 9:21,141,026...21,150,628
Ensembl chr 9:21,141,026...21,150,657

G

KIT proto-oncogene receptor tyrosine kinase

multiple interactions

[Curcumin binds to carboxymethyl-chitosan analog] inhibits the reaction [AGT protein modified form results in increased expression of KIT protein]; [Curcumin binds to carboxymethyl-chitosan analog] which results in decreased expression of KIT protein

NCBI chr 5:75,735,647...75,817,382
Ensembl chr 5:75,735,576...75,817,382

G

Kruppel-like transcription factor 10

decreases expression

Curcumin results in decreased expression of KLF10 mRNA

NCBI chr15:38,291,702...38,300,950
Ensembl chr15:38,291,707...38,300,950

G

Kruppel-like transcription factor 6

increases expression

Curcumin results in increased expression of KLF6 mRNA

NCBI chr13:5,911,488...5,920,392
Ensembl chr13:5,911,481...5,920,393

G

kelch-like 21

increases expression

Curcumin results in increased expression of KLHL21 mRNA

NCBI chr 4:152,093,348...152,102,134
Ensembl chr 4:152,093,260...152,102,137

G

kelch-like 24

decreases expression

Curcumin results in decreased expression of KLHL24 mRNA

NCBI chr16:19,916,286...19,947,976
Ensembl chr16:19,916,292...19,947,971

G

lysine methyltransferase 5A

decreases expression

Curcumin results in decreased expression of KMT5A mRNA; Curcumin results in decreased expression of KMT5A protein

NCBI chr 5:124,577,980...124,600,371
Ensembl chr 5:124,577,993...124,600,371

G

Kirsten rat sarcoma viral oncogene homolog

decreases expression
multiple interactions

Curcumin analog results in decreased expression of KRAS mRNA; Curcumin results in decreased expression of KRAS mRNA
Curcumin affects the reaction [KRAS protein affects the localization of TRP53 protein]; Curcumin inhibits the reaction [KRAS protein results in decreased expression of XPO1 protein]

PMID:17041101 PMID:21519798

NCBI chr 6:145,162,425...145,197,631
Ensembl chr 6:145,162,425...145,195,965

G

keratin associated protein 2-4

decreases expression

Curcumin results in decreased expression of KRTAP2-1 mRNA

NCBI chr11:99,504,843...99,505,672
Ensembl chr11:99,504,845...99,505,672

G

kynureninase

increases expression

Curcumin results in increased expression of KYNU mRNA

NCBI chr 2:43,445,270...43,572,734
Ensembl chr 2:43,445,341...43,572,734

G

lysosomal-associated membrane protein 1

affects expression
multiple interactions

Curcumin affects the expression of LAMP1 mRNA
Curcumin promotes the reaction [sodium arsenite results in increased expression of LAMP1 protein]; NFE2L2 protein affects the reaction [Curcumin promotes the reaction [sodium arsenite results in increased expression of LAMP1 protein]]

PMID:18539377 PMID:34758851

NCBI chr 8:13,209,161...13,225,338
Ensembl chr 8:13,209,161...13,225,338

G

lipopolysaccharide binding protein

multiple interactions

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of LBP mRNA]

NCBI chr 2:158,148,413...158,174,772
Ensembl chr 2:158,148,413...158,174,772

G

lipocalin 2

multiple interactions

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of LCN2 mRNA]
Curcumin inhibits the reaction [Cadmium Chloride results in increased export of LCN2 protein]; Curcumin inhibits the reaction [maleic acid results in increased secretion of LCN2 protein]

PMID:18200517 PMID:25119790 PMID:29421648

NCBI chr 2:32,274,649...32,277,751
Ensembl chr 2:32,274,645...32,278,264

G

lymphocyte cytosolic protein 1

multiple interactions

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of LCP1 mRNA]

NCBI chr14:75,368,570...75,468,282
Ensembl chr14:75,368,541...75,468,282

G

lymphocyte cytosolic protein 2

increases expression

Curcumin results in increased expression of LCP2 mRNA

NCBI chr11:33,996,928...34,042,281
Ensembl chr11:33,996,920...34,042,295

G

lactate dehydrogenase A

decreases expression
multiple interactions

Curcumin results in decreased expression of LDHA protein
ATF4 inhibits the reaction [Curcumin results in decreased expression of LDHA protein]; Curcumin inhibits the reaction [Hypochlorous Acid results in increased activity of LDHA protein]; Curcumin inhibits the reaction [Sirolimus results in increased expression of LDHA protein]

PMID:36640941 PMID:36924976

NCBI chr 7:46,491,698...46,505,051
Ensembl chr 7:46,490,899...46,505,051

G

low density lipoprotein receptor

multiple interactions
affects expression
increases expression

Curcumin inhibits the reaction [INSIG2 protein results in decreased expression of LDLR mRNA]; Curcumin results in increased expression of and results in increased activity of LDLR protein
Curcumin affects the expression of LDLR mRNA
Curcumin results in increased expression of LDLR mRNA; Curcumin results in increased expression of LDLR protein

PMID:16713233 PMID:16963807 PMID:18704882 PMID:27208389

NCBI chr 9:21,634,872...21,661,215
Ensembl chr 9:21,634,779...21,661,215

G

lymphoid enhancer binding factor 1

increases expression
multiple interactions

Curcumin results in increased expression of LEF1 mRNA
Curcumin inhibits the reaction [bisphenol A results in decreased expression of LEF1 mRNA]

NCBI chr 3:130,903,972...131,018,006
Ensembl chr 3:130,904,120...131,018,005

G

legumain

multiple interactions

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of LGMN mRNA]

NCBI chr12:102,360,341...102,405,987
Ensembl chr12:102,360,343...102,406,072

G

luteinizing hormone beta

multiple interactions

Curcumin inhibits the reaction [sodium arsenite results in decreased expression of LHB protein]

NCBI chr 7:45,070,370...45,071,278
Ensembl chr 7:45,070,244...45,071,321

G

LIM homeobox protein 5

affects expression

Curcumin affects the expression of LHX5 mRNA

NCBI chr 5:120,569,951...120,579,522
Ensembl chr 5:120,569,764...120,579,288

G

ligase III, DNA, ATP-dependent

multiple interactions

Curcumin inhibits the reaction [Arsenic results in decreased expression of LIG3 mRNA]; Curcumin inhibits the reaction [Arsenic results in decreased expression of LIG3 protein]

NCBI chr11:82,671,977...82,695,100
Ensembl chr11:82,671,934...82,695,100

G

ligase IV, DNA, ATP-dependent

multiple interactions

Curcumin inhibits the reaction [Arsenic results in decreased expression of LIG4 mRNA]; Curcumin inhibits the reaction [Arsenic results in decreased expression of LIG4 protein]

NCBI chr 8:10,020,020...10,027,680
Ensembl chr 8:10,019,049...10,027,686

G

lipase, hepatic

affects expression

Curcumin affects the expression of LIPC mRNA

NCBI chr 9:70,705,410...70,859,503
Ensembl chr 9:70,705,410...70,859,508

G

lysyl oxidase

multiple interactions

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of LOX mRNA]

NCBI chr18:52,649,132...52,662,939
Ensembl chr18:52,649,139...52,662,939

G

lysophosphatidic acid receptor 1

decreases expression

Curcumin results in decreased expression of LPAR1 mRNA

NCBI chr 4:58,435,252...58,554,601
Ensembl chr 4:58,435,255...58,553,898

G

lipoprotein lipase

affects expression

Curcumin affects the expression of LPL mRNA

NCBI chr 8:69,333,207...69,359,584
Ensembl chr 8:69,333,143...69,360,100

G

low density lipoprotein receptor-related protein 5

multiple interactions
increases expression

Curcumin inhibits the reaction [bisphenol A results in decreased expression of LRP5 mRNA]
Curcumin results in increased expression of LRP5 mRNA

NCBI chr19:3,634,825...3,736,574
Ensembl chr19:3,634,828...3,736,564

G

low density lipoprotein receptor-related protein 6

multiple interactions
increases expression

Curcumin inhibits the reaction [bisphenol A results in decreased expression of LRP6 mRNA]
Curcumin results in increased expression of LRP6 mRNA

NCBI chr 6:134,423,439...134,543,876
Ensembl chr 6:134,423,439...134,543,928

G

leucine rich repeat protein 3, neuronal

increases expression

Curcumin results in increased expression of LRRN3 mRNA

NCBI chr12:41,501,667...41,536,056
Ensembl chr12:41,501,667...41,536,430

G

lanosterol synthase

affects expression
decreases expression

Curcumin affects the expression of LSS mRNA
Curcumin results in decreased expression of LSS mRNA

NCBI chr10:76,367,303...76,392,973
Ensembl chr10:76,367,422...76,392,972

G

lymphotoxin A

decreases expression
multiple interactions
increases expression

Curcumin results in decreased expression of LTA mRNA
[arsenic trioxide co-treated with Curcumin] results in increased expression of LTA protein
Curcumin results in increased expression of LTA mRNA

PMID:16101141 PMID:17198877 PMID:27430728

NCBI chr17:35,422,141...35,424,568
Ensembl chr17:35,422,141...35,424,327

G

lymphotoxin B

increases expression
decreases expression

Curcumin results in increased expression of LTB mRNA
Curcumin results in decreased expression of LTB mRNA

PMID:16751071 PMID:17198877

NCBI chr17:35,413,483...35,415,281
Ensembl chr17:35,413,415...35,415,296

G

lymphotoxin B receptor

multiple interactions

Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of LTBR mRNA]

NCBI chr 6:125,283,534...125,291,026
Ensembl chr 6:125,283,534...125,290,848

G

lysozyme 1

decreases expression

Curcumin results in decreased expression of LYZ1 mRNA

NCBI chr10:117,123,700...117,128,773
Ensembl chr10:117,123,702...117,128,773

G

lysozyme 2

multiple interactions
affects expression

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of LYZ mRNA]
Curcumin affects the expression of LYZ2 mRNA

PMID:18200517 PMID:18539377

NCBI chr10:117,113,446...117,118,177
Ensembl chr10:117,113,236...117,118,226

G

mucosal vascular addressin cell adhesion molecule 1

multiple interactions

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of MADCAM1 mRNA]

NCBI chr10:79,500,393...79,504,376
Ensembl chr10:79,500,393...79,504,371

G

monoamine oxidase A

multiple interactions

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of MAOA mRNA]

NCBI chr X:16,485,937...16,554,051
Ensembl chr X:16,485,937...16,554,057

G

microtubule-associated protein 1 light chain 3 beta

multiple interactions
decreases expression
increases expression
increases lipidation

3-methyladenine inhibits the reaction [Curcumin results in increased lipidation of MAP1LC3B protein]; 4-phenylbutyric acid inhibits the reaction [Curcumin results in decreased expression of MAP1LC3B protein]; bafilomycin A1 promotes the reaction [Curcumin results in increased lipidation of MAP1LC3B protein]; Curcumin inhibits the reaction [4-phenylbutyric acid results in decreased expression of MAP1LC3B protein]; Curcumin inhibits the reaction [Sirolimus results in increased expression of MAP1LC3B protein]; Curcumin inhibits the reaction [Tunicamycin results in increased expression of MAP1LC3B protein]; Sirolimus promotes the reaction [Curcumin results in increased lipidation of MAP1LC3B protein]; U 0126 inhibits the reaction [Curcumin results in increased lipidation of MAP1LC3B protein]
Curcumin results in increased expression of MAP1LC3B mRNA

PMID:34634291 PMID:36640941

NCBI chr 8:122,317,177...122,325,499
Ensembl chr 8:122,317,100...122,325,499

G

mitogen-activated protein kinase kinase 1

multiple interactions

MAP2K1 protein inhibits the reaction [Curcumin inhibits the reaction [Mitomycin results in increased expression of RAD51 protein]]; MAP2K1 protein inhibits the reaction [Curcumin inhibits the reaction [Mitomycin results in increased phosphorylation of MAPK1 protein]]; MAP2K1 protein inhibits the reaction [Curcumin inhibits the reaction [Mitomycin results in increased phosphorylation of MAPK3 protein]]; MAP2K1 results in decreased susceptibility to [Curcumin co-treated with Mitomycin]

NCBI chr 9:64,093,066...64,160,887
Ensembl chr 9:64,093,052...64,160,913

G

mitogen-activated protein kinase kinase 2

multiple interactions

MAP2K2 protein inhibits the reaction [Curcumin inhibits the reaction [Mitomycin results in increased expression of RAD51 protein]]; MAP2K2 protein inhibits the reaction [Curcumin inhibits the reaction [Mitomycin results in increased phosphorylation of MAPK1 protein]]; MAP2K2 protein inhibits the reaction [Curcumin inhibits the reaction [Mitomycin results in increased phosphorylation of MAPK3 protein]]; MAP2K2 results in decreased susceptibility to [Curcumin co-treated with Mitomycin]

NCBI chr10:80,941,749...80,960,531
Ensembl chr10:80,941,749...80,969,809

G

mitogen-activated protein kinase kinase 3

increases expression

Curcumin results in increased expression of MAP2K3 mRNA

NCBI chr11:60,822,880...60,843,637
Ensembl chr11:60,822,859...60,843,637

G

mitogen-activated protein kinase kinase 4

decreases expression
increases phosphorylation

Curcumin results in decreased expression of MAP2K4 mRNA
Curcumin increases phosphorylation of MAP2K4 protein in uterine cervix

CTD
RGD

PMID:15713895 PMID:25198898

NCBI chr11:65,579,070...65,679,185
Ensembl chr11:65,579,069...65,679,123

G

mitogen-activated protein kinase kinase kinase 1

multiple interactions
decreases expression

Curcumin inhibits the reaction [MAP3K1 protein results in increased expression of IVL mRNA]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of MAP3K1 mRNA]
Curcumin results in decreased expression of MAP3K1 mRNA

PMID:15713895 PMID:17148446 PMID:23452621

NCBI chr13:111,882,962...111,954,803
Ensembl chr13:111,882,962...111,945,527

G

mitogen-activated protein kinase kinase kinase 5

increases phosphorylation

Curcumin increases phosphorylation of MAP3K5 protein in uterine cervix

RGD

NCBI chr10:19,809,847...20,018,496
Ensembl chr10:19,810,218...20,018,499

G

mitogen-activated protein kinase 1

multiple interactions
decreases phosphorylation
increases phosphorylation
decreases expression
decreases activity

[bisdemethoxycurcumin co-treated with Curcumin co-treated with demethoxycurcumin] inhibits the reaction [VEGF protein results in increased phosphorylation of MAPK1 protein]; [Curcumin results in decreased activity of MAPK1 protein] which results in increased susceptibility to Cisplatin; [ERBB2 protein results in increased susceptibility to Curcumin analog] which results in decreased phosphorylation of MAPK1 protein; Acetylcysteine inhibits the reaction [Curcumin results in increased phosphorylation of MAPK1 protein]; Arsenic Trioxide promotes the reaction [Curcumin results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Bortezomib promotes the reaction [Curcumin results in decreased phosphorylation of MAPK1 protein]; Curcumin inhibits the reaction [Acids results in increased phosphorylation of MAPK1 protein]; Curcumin inhibits the reaction [bromopyruvate results in increased phosphorylation of MAPK1 protein]; Curcumin inhibits the reaction [cadmium sulfate results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Curcumin inhibits the reaction [EGF protein results in increased phosphorylation of MAPK1 protein]; Curcumin inhibits the reaction [Furazolidone results in increased phosphorylation of MAPK1 protein]; Curcumin inhibits the reaction [Mitomycin results in increased phosphorylation of MAPK1 protein]; Curcumin inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; Curcumin inhibits the reaction [VEGF protein results in increased phosphorylation of MAPK1 protein]; Curcumin results in increased phosphorylation of and results in increased activity of MAPK1 protein; MAP2K1 protein inhibits the reaction [Curcumin inhibits the reaction [Mitomycin results in increased phosphorylation of MAPK1 protein]]; MAP2K2 protein inhibits the reaction [Curcumin inhibits the reaction [Mitomycin results in increased phosphorylation of MAPK1 protein]]; MAPK1 protein affects the reaction [Curcumin results in increased expression of CDKN1A mRNA]; rottlerin inhibits the reaction [Curcumin results in increased expression of MAPK1 protein]; U 0126 inhibits the reaction [Curcumin results in increased phosphorylation of MAPK1 protein]; U 0126 promotes the reaction [Curcumin inhibits the reaction [Mitomycin results in increased phosphorylation of MAPK1 protein]]
Curcumin inhibits the reaction [Corticosterone results in increased phosphorylation of MAPK1 protein]; Curcumin inhibits the reaction [Fructose results in increased phosphorylation of MAPK1 protein]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein]; Curcumin inhibits the reaction [PDGFB protein results in increased phosphorylation of MAPK1 protein]; Curcumin inhibits the reaction [sodium arsenite results in decreased phosphorylation of MAPK1 protein]; Curcumin inhibits the reaction [Tetracaine results in increased phosphorylation of MAPK1 protein]; Curcumin results in decreased phosphorylation of and results in decreased activity of MAPK1 protein; tin protoporphyrin IX inhibits the reaction [Curcumin inhibits the reaction [PDGFB protein results in increased phosphorylation of MAPK1 protein]]
[Curcumin binds to 4-bis(2-chloroethyl)aminobenzaldehyde] inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein]; [piperlongumine co-treated with Curcumin] results in decreased activity of MAPK1 protein; Curcumin inhibits the reaction [Acrylamide results in increased phosphorylation of MAPK1 protein]; Curcumin inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of MAPK1 protein]; Curcumin inhibits the reaction [sodium arsenite results in increased phosphorylation of MAPK1 protein]; Curcumin inhibits the reaction [Tobacco Smoke Pollution results in increased phosphorylation of MAPK1 protein]
Curcumin results in decreased expression of MAPK1 protein

PMID:11035063 PMID:11981161 PMID:16934299 PMID:17372590 PMID:17535857 More...

NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317

G

mitogen-activated protein kinase 10

multiple interactions

Curcumin analog inhibits the reaction [Rotenone results in increased phosphorylation of MAPK10 protein]; Curcumin inhibits the reaction [sodium arsenite results in increased expression of MAPK10 protein]; Curcumin inhibits the reaction [sodium arsenite results in increased phosphorylation of MAPK10 protein]

PMID:24952339 PMID:27535828 PMID:27966075

NCBI chr 5:103,056,413...103,359,200
Ensembl chr 5:103,055,814...103,359,200

G

mitogen-activated protein kinase 12

increases activity

Curcumin results in increased activity of MAPK12 protein

NCBI chr15:89,014,787...89,025,270
Ensembl chr15:89,014,787...89,024,906

G

mitogen-activated protein kinase 14

multiple interactions

Curcumin inhibits the reaction [[TNF protein co-treated with IL1B protein] results in increased phosphorylation of MAPK14 protein]; Curcumin inhibits the reaction [Hydrogen Peroxide results in increased expression of MAPK14 mRNA]; MAPK14 protein affects the reaction [Curcumin results in increased expression of HMOX1 protein]

PMID:17151092 PMID:18357586 PMID:31521693

NCBI chr17:28,910,316...28,967,379
Ensembl chr17:28,910,303...28,967,380

G

mitogen-activated protein kinase 3

multiple interactions
decreases phosphorylation
increases phosphorylation
decreases expression
decreases activity

[bisdemethoxycurcumin co-treated with Curcumin co-treated with demethoxycurcumin] inhibits the reaction [VEGF protein results in increased phosphorylation of MAPK3 protein]; [Curcumin results in decreased activity of MAPK3 protein] which results in increased susceptibility to Cisplatin; [ERBB2 protein results in increased susceptibility to Curcumin analog] which results in decreased phosphorylation of MAPK3 protein; Acetylcysteine inhibits the reaction [Curcumin results in increased phosphorylation of MAPK3 protein]; Arsenic Trioxide promotes the reaction [Curcumin results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Bortezomib promotes the reaction [Curcumin results in decreased phosphorylation of MAPK3 protein]; Curcumin inhibits the reaction [Acids results in increased phosphorylation of MAPK3 protein]; Curcumin inhibits the reaction [bromopyruvate results in increased phosphorylation of MAPK3 protein]; Curcumin inhibits the reaction [cadmium sulfate results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Curcumin inhibits the reaction [EGF protein results in increased phosphorylation of MAPK3 protein]; Curcumin inhibits the reaction [Mitomycin results in increased phosphorylation of MAPK3 protein]; Curcumin inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]; Curcumin inhibits the reaction [VEGF protein results in increased phosphorylation of MAPK3 protein]; Curcumin results in increased phosphorylation of and results in increased activity of MAPK3 protein; MAP2K1 protein inhibits the reaction [Curcumin inhibits the reaction [Mitomycin results in increased phosphorylation of MAPK3 protein]]; MAP2K2 protein inhibits the reaction [Curcumin inhibits the reaction [Mitomycin results in increased phosphorylation of MAPK3 protein]]; rottlerin inhibits the reaction [Curcumin results in increased expression of MAPK3 protein]; U 0126 inhibits the reaction [Curcumin results in increased phosphorylation of MAPK3 protein]; U 0126 promotes the reaction [Curcumin inhibits the reaction [Mitomycin results in increased phosphorylation of MAPK3 protein]]
Curcumin inhibits the reaction [Corticosterone results in increased phosphorylation of MAPK3 protein]; Curcumin inhibits the reaction [Fructose results in increased phosphorylation of MAPK3 protein]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein]; Curcumin inhibits the reaction [PDGFB protein results in increased phosphorylation of MAPK3 protein]; Curcumin inhibits the reaction [sodium arsenite results in decreased phosphorylation of MAPK3 protein]; Curcumin inhibits the reaction [Tetracaine results in increased phosphorylation of MAPK3 protein]; Curcumin results in decreased phosphorylation of and results in decreased activity of MAPK3 protein; tin protoporphyrin IX inhibits the reaction [Curcumin inhibits the reaction [PDGFB protein results in increased phosphorylation of MAPK3 protein]]
[Curcumin binds to 4-bis(2-chloroethyl)aminobenzaldehyde] inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein]; [piperlongumine co-treated with Curcumin] results in decreased activity of MAPK3 protein; Curcumin inhibits the reaction [Acrylamide results in increased phosphorylation of MAPK3 protein]; Curcumin inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of MAPK3 protein]; Curcumin inhibits the reaction [sodium arsenite results in increased phosphorylation of MAPK3 protein]; Curcumin inhibits the reaction [Tobacco Smoke Pollution results in increased phosphorylation of MAPK3 protein]
Curcumin results in decreased expression of MAPK3 protein

PMID:11035063 PMID:11981161 PMID:16934299 PMID:17372590 PMID:17535857 More...

NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991

G

mitogen-activated protein kinase 8

multiple interactions
increases phosphorylation
decreases phosphorylation
increases expression

Curcumin inhibits the reaction [Hydrogen Peroxide results in increased expression of MAPK8 mRNA]; Curcumin inhibits the reaction [Nicotine results in increased phosphorylation of MAPK8 protein]; MAPK8 protein affects the reaction [Curcumin results in increased expression of CDKN1A mRNA]
Curcumin increases phosphorylation of MAPK8 protein in uterine cervix
Curcumin results in decreased phosphorylation of MAPK8 protein
Curcumin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK8 protein]; Curcumin inhibits the reaction [sodium arsenite results in increased expression of MAPK8 protein]; Curcumin inhibits the reaction [sodium arsenite results in increased phosphorylation of MAPK8 protein]; Curcumin inhibits the reaction [Tetracaine results in increased phosphorylation of MAPK8 protein]; Curcumin results in decreased phosphorylation of and results in decreased activity of MAPK8 protein
Curcumin inhibits the reaction [Acrylamide results in increased phosphorylation of MAPK8 protein]; Curcumin inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of MAPK8 protein]; Curcumin inhibits the reaction [Bleomycin results in increased phosphorylation of MAPK8 protein]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK8 protein]; Curcumin inhibits the reaction [sodium arsenite results in increased phosphorylation of MAPK8 protein]
Curcumin results in increased expression of MAPK8 mRNA
Curcumin results in increased phosphorylation of MAPK8 protein

CTD
RGD

PMID:11981161 PMID:16101141 PMID:16678799 PMID:16934299 PMID:17372590 More...

NCBI chr14:33,099,855...33,169,213
Ensembl chr14:33,099,855...33,169,115

G

mitogen-activated protein kinase 9

multiple interactions
decreases phosphorylation
increases phosphorylation

Curcumin inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of MAPK9 protein]; Curcumin inhibits the reaction [sodium arsenite results in increased phosphorylation of MAPK9 protein]
Curcumin results in decreased phosphorylation of MAPK9 protein
Curcumin results in increased phosphorylation of MAPK9 protein
Curcumin inhibits the reaction [sodium arsenite results in increased expression of MAPK9 protein]; Curcumin inhibits the reaction [sodium arsenite results in increased phosphorylation of MAPK9 protein]; Curcumin inhibits the reaction [Tetracaine results in increased phosphorylation of MAPK9 protein]; Curcumin results in decreased phosphorylation of and results in decreased activity of MAPK9 protein

PMID:11981161 PMID:17372590 PMID:18316600 PMID:18321868 PMID:18332871 More...

NCBI chr11:49,737,558...49,777,248
Ensembl chr11:49,737,578...49,777,248

G

microtubule-associated protein tau

multiple interactions

Curcumin inhibits the reaction [Hydrogen Peroxide results in decreased expression of MAPT mRNA]

NCBI chr11:104,120,235...104,222,916
Ensembl chr11:104,122,216...104,222,916

G

myeloid cell leukemia sequence 1

decreases expression
multiple interactions

Curcumin results in decreased expression of MCL1 protein alternative form
[Curcumin co-treated with Arsenic Trioxide] results in decreased expression of MCL1 protein

PMID:18829502 PMID:34675983

NCBI chr 3:95,564,017...95,583,553
Ensembl chr 3:95,566,099...95,570,487

G

minichromosome maintenance complex component 2

decreases expression

Curcumin results in decreased expression of MCM2 mRNA

NCBI chr 6:88,860,456...88,875,762
Ensembl chr 6:88,860,456...88,875,762

G

minichromosome maintenance complex component 7

decreases expression

Curcumin results in decreased expression of MCM7 mRNA

NCBI chr 5:138,162,845...138,170,675
Ensembl chr 5:138,162,845...138,170,684

G

transformed mouse 3T3 cell double minute 2

decreases expression
increases expression
multiple interactions

[Curcumin results in decreased expression of MDM2 protein] which results in decreased expression of CDKN1A mRNA; Curcumin results in decreased expression of MDM2 mRNA; Curcumin results in decreased expression of MDM2 protein
Curcumin analog results in increased expression of MDM2 mRNA
Curcumin inhibits the reaction [bisphenol A results in increased phosphorylation of MDM2 protein]

PMID:17332326 PMID:24831732 PMID:26409325

NCBI chr10:117,524,780...117,546,663
Ensembl chr10:117,524,780...117,546,663

G

methyl CpG binding protein 2

decreases expression

Curcumin results in decreased expression of MECP2 protein

NCBI chr X:73,070,198...73,129,296
Ensembl chr X:73,070,198...73,129,296

G

myocyte enhancer factor 2C

decreases expression

Curcumin results in decreased expression of MEF2C mRNA

NCBI chr13:83,652,136...83,815,197
Ensembl chr13:83,652,153...83,815,199

G

melanotransferrin

decreases expression

Curcumin results in decreased expression of MELTF mRNA

NCBI chr16:31,697,449...31,717,838
Ensembl chr16:31,697,628...31,717,838

G

mitofusin 1

increases expression

Curcumin results in increased expression of MFN1 protein

NCBI chr 3:32,583,594...32,633,384
Ensembl chr 3:32,583,614...32,633,388

G

MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase

increases expression

Curcumin results in increased expression of MFNG mRNA

NCBI chr15:78,640,082...78,657,678
Ensembl chr15:78,640,082...78,657,675

G

O-6-methylguanine-DNA methyltransferase

decreases expression
increases expression
decreases activity
multiple interactions

Curcumin results in decreased expression of MGMT mRNA
Curcumin results in increased expression of MGMT mRNA
Curcumin results in decreased activity of MGMT protein
Curcumin results in increased expression of and results in increased activity of MGMT protein

PMID:16950796 PMID:17596214

NCBI chr 7:136,496,315...136,732,001
Ensembl chr 7:136,496,343...136,731,995

G

microsomal glutathione S-transferase 1

increases expression

Curcumin results in increased expression of MGST1 mRNA

NCBI chr 6:138,117,525...138,133,753
Ensembl chr 6:138,117,314...138,133,753

G

microRNA 125a

decreases expression
multiple interactions

Curcumin results in decreased expression of MIR125A mRNA
Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of MIR125A mRNA]; MIR125A mRNA inhibits the reaction [Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in decreased expression of ABCA1 mRNA]]; MIR125A mRNA inhibits the reaction [Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in decreased expression of ABCA1 protein]]; MIR125A mRNA inhibits the reaction [Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of CCL2 protein]]; MIR125A mRNA inhibits the reaction [Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of IL6 protein]]; MIR125A mRNA inhibits the reaction [Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of TNF protein]]

PMID:29723631 PMID:33952798

NCBI chr17:18,051,074...18,051,141
Ensembl chr17:18,051,074...18,051,141

G

microRNA 146

multiple interactions

Curcumin inhibits the reaction [[ferrous sulfate co-treated with aluminum sulfate] results in increased expression of MIR146A mRNA]

NCBI chr11:43,265,224...43,265,288
Ensembl chr11:43,265,224...43,265,288

G

microRNA 19a

multiple interactions

Curcumin inhibits the reaction [bisphenol A results in increased expression of MIR19A mRNA]

NCBI chr14:115,281,432...115,281,513
Ensembl chr14:115,281,432...115,281,513

G

microRNA 21a

decreases expression

Curcumin results in decreased expression of MIR21 mRNA

NCBI chr11:86,474,893...86,474,984
Ensembl chr11:86,474,893...86,474,984

G

microRNA 22

increases expression

Curcumin results in increased expression of MIR22

NCBI chr11:75,354,542...75,354,636
Ensembl chr11:75,354,542...75,354,636

G

microRNA 222

decreases expression

Curcumin results in decreased expression of MIR222 mRNA

NCBI chr X:19,013,132...19,013,210
Ensembl chr X:19,013,132...19,013,210

G

microRNA 223

increases expression

Curcumin results in increased expression of MIR223 mRNA

NCBI chr X:95,286,423...95,286,532
Ensembl chr X:95,286,423...95,286,532

G

Mir22 host gene (non-protein coding)

increases expression

Curcumin results in increased expression of MIR22HG mRNA

NCBI chr11:75,352,365...75,357,516
Ensembl chr11:75,352,365...75,357,502

G

microRNA 27a

decreases expression

Curcumin results in decreased expression of MIR27A mRNA

NCBI chr 8:84,935,301...84,935,387
Ensembl chr 8:84,935,301...84,935,387

G

microRNA 27b

decreases expression

Curcumin results in decreased expression of MIR27B mRNA

NCBI chr13:63,448,526...63,448,598
Ensembl chr13:63,448,526...63,448,598

G

microRNA 30a

increases expression

Curcumin results in increased expression of MIR30A mRNA

NCBI chr 1:23,311,350...23,311,420
Ensembl chr 1:23,311,350...23,311,420

G

microRNA 34a

multiple interactions

Curcumin inhibits the reaction [Cyclosporine results in increased expression of MIR34A mRNA]

NCBI chr 4:150,152,911...150,153,012
Ensembl chr 4:150,152,911...150,153,012

G

microRNA 532

increases expression
multiple interactions

Curcumin results in increased expression of MIR532 mRNA
MIR532 affects the reaction [Curcumin results in decreased expression of AKT3 protein]; MIR532 affects the reaction [Curcumin results in decreased phosphorylation of AKT1 protein]; NRIP1 mRNA alternative form inhibits the reaction [Curcumin results in increased expression of MIR532 mRNA]

NCBI chr X:7,114,641...7,114,736
Ensembl chr X:7,114,641...7,114,736

G

microRNA 802

multiple interactions

Curcumin inhibits the reaction [Acetaminophen results in increased expression of MIR802 mRNA]

NCBI chr16:93,166,608...93,166,704
Ensembl chr16:93,166,608...93,166,704

G

microRNA 99a

multiple interactions

Curcumin inhibits the reaction [benzyl isothiocyanate results in increased expression of MIR99A mRNA]

NCBI chr16:77,395,824...77,395,888
Ensembl chr16:77,395,824...77,395,888

G

antigen identified by monoclonal antibody Ki 67

multiple interactions
decreases expression

[Curcumin co-treated with Gemcitabine] results in decreased expression of MKI67 protein
Curcumin results in decreased expression of MKI67 protein

PMID:17440100 PMID:18226269 PMID:19372569

NCBI chr 7:135,291,513...135,318,286
Ensembl chr 7:135,291,513...135,318,090

G

membrane metallo endopeptidase

decreases expression

Curcumin results in decreased expression of MME mRNA

NCBI chr 3:63,202,632...63,291,134
Ensembl chr 3:63,148,958...63,293,451

G

matrix metallopeptidase 10

increases expression

Curcumin results in increased expression of MMP10 mRNA

NCBI chr 9:7,502,343...7,510,243
Ensembl chr 9:7,502,353...7,510,241

G

matrix metallopeptidase 13

multiple interactions

Curcumin inhibits the reaction [Chloramphenicol results in increased expression of MMP13 mRNA]

NCBI chr 9:7,272,514...7,283,333
Ensembl chr 9:7,272,514...7,283,331

G

matrix metallopeptidase 14 (membrane-inserted)

decreases expression
multiple interactions

Curcumin results in decreased expression of MMP14 protein
Curcumin inhibits the reaction [Indomethacin results in decreased expression of MMP14 protein]
Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of MMP14 mRNA]

PMID:16934674 PMID:18200517 PMID:18495463

NCBI chr14:54,669,055...54,679,913
Ensembl chr14:54,669,069...54,682,821

G

matrix metallopeptidase 1b (interstitial collagenase)

multiple interactions

Curcumin inhibits the reaction [IL1B protein results in increased expression of MMP1 mRNA]

NCBI chr 9:7,367,670...7,388,026
Ensembl chr 9:7,368,239...7,388,047

G

matrix metallopeptidase 2

multiple interactions
decreases expression
decreases activity
increases activity

Curcumin inhibits the reaction [4,6-dimorpholino-N-(4-nitrophenyl)-1,3,5-triazin-2-amine results in increased expression of MMP2 protein]; Curcumin inhibits the reaction [Sirolimus results in increased expression of MMP2 protein]; Curcumin inhibits the reaction [VEGFA protein results in increased expression of and results in increased activity of MMP2 protein]; Curcumin inhibits the reaction [VIP protein results in increased activity of MMP2 protein]; Curcumin results in decreased secretion of and results in decreased activity of MMP2 protein modified form; TNFSF10 protein promotes the reaction [Curcumin results in decreased expression of MMP2 protein]
Curcumin results in decreased activity of MMP2 protein
Curcumin results in increased activity of MMP2 protein
Curcumin inhibits the reaction [Bleomycin results in increased expression of and results in increased secretion of MMP2 protein]; Curcumin inhibits the reaction [Bleomycin results in increased expression of MMP2 mRNA]; Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of MMP2 mRNA]
2-chloro-5-nitrobenzanilide inhibits the reaction [Curcumin results in increased activity of MMP2 protein]; Curcumin inhibits the reaction [Hydrogen Peroxide results in decreased activity of MMP2 protein]

PMID:16934674 PMID:17531121 PMID:17996675 PMID:18200517 PMID:18226269 More...

NCBI chr 8:93,553,920...93,580,049
Ensembl chr 8:93,553,919...93,580,048

G

matrix metallopeptidase 3

increases expression

Curcumin results in increased expression of MMP3 mRNA

PMID:15713895 PMID:18321735

NCBI chr 9:7,445,845...7,455,975
Ensembl chr 9:7,445,822...7,455,975

G

matrix metallopeptidase 7

multiple interactions

Curcumin inhibits the reaction [epigallocatechin gallate results in increased expression of MMP7 protein]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of MMP7 mRNA]; Curcumin inhibits the reaction [Tretinoin results in increased expression of MMP7 mRNA]

PMID:17928719 PMID:23452621

NCBI chr 9:7,692,095...7,699,587
Ensembl chr 9:7,692,091...7,699,586

G

matrix metallopeptidase 9

multiple interactions
decreases activity
decreases expression
increases activity
affects expression

3-caffeoyl-4-dihydrocaffeoylquinic acid promotes the reaction [Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP9 mRNA]]; 4-methyl-N1-(3-phenylpropyl)benzene-1,2-diamine promotes the reaction [Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP9 mRNA]]; 4-methyl-N1-(3-phenylpropyl)benzene-1,2-diamine promotes the reaction [Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP9 protein]]; Curcumin inhibits the reaction [4,6-dimorpholino-N-(4-nitrophenyl)-1,3,5-triazin-2-amine results in increased expression of MMP9 protein]; Curcumin inhibits the reaction [Cadmium results in increased expression of MMP9 mRNA]; Curcumin inhibits the reaction [IL1B protein results in increased expression of MMP9 protein]; Curcumin inhibits the reaction [Paclitaxel results in increased expression of MMP9 protein]; Curcumin inhibits the reaction [Sirolimus results in increased expression of MMP9 protein]; Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of and results in increased activity of MMP9 protein]; Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP9 mRNA]; Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP9 protein]; Curcumin inhibits the reaction [TNF protein results in increased expression of MMP9 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of MMP9 protein]; Curcumin inhibits the reaction [VIP protein results in increased activity of MMP9 protein]; Curcumin promotes the reaction [3-caffeoyl-4-dihydrocaffeoylquinic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP9 mRNA]]; Curcumin promotes the reaction [4-methyl-N1-(3-phenylpropyl)benzene-1,2-diamine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP9 mRNA]]; Curcumin promotes the reaction [4-methyl-N1-(3-phenylpropyl)benzene-1,2-diamine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP9 protein]]; Curcumin results in decreased secretion of and results in decreased activity of MMP9 protein; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased expression of MMP9 protein]]; TNFSF10 protein promotes the reaction [Curcumin results in decreased expression of MMP9 protein]
Curcumin results in decreased activity of MMP9 protein
Curcumin results in increased activity of MMP9 protein
Curcumin affects the expression of MMP9 mRNA; Curcumin affects the expression of MMP9 protein
2-chloro-5-nitrobenzanilide inhibits the reaction [Curcumin results in increased activity of MMP9 protein]; [Zinc binds to Curcumin] inhibits the reaction [Acetic Acid results in increased expression of MMP9 mRNA]; Curcumin inhibits the reaction [Ethanol results in increased expression of MMP9 mRNA]
[Curcumin co-treated with Gemcitabine] results in decreased expression of MMP9 protein; [Dexamethasone co-treated with Curcumin] inhibits the reaction [[Ovalbumin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of and results in increased activity of MMP9 protein]; Curcumin inhibits the reaction [[Ovalbumin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased activity of MMP9 protein]; Curcumin inhibits the reaction [Bleomycin results in increased expression of and results in increased secretion of MMP9 protein]; Curcumin inhibits the reaction [Bleomycin results in increased expression of MMP9 mRNA]

PMID:16219905 PMID:16243823 PMID:17291458 PMID:17440100 PMID:17531121 More...

NCBI chr 2:164,782,246...164,797,770
Ensembl chr 2:164,782,700...164,797,770

G

M phase phosphoprotein 6

decreases expression

Curcumin results in decreased expression of MPHOSPH6 mRNA

NCBI chr 8:118,518,376...118,528,713
Ensembl chr 8:118,518,384...118,528,682

G

myeloperoxidase

multiple interactions
decreases activity

Curcumin inhibits the reaction [Dinitrochlorobenzene results in decreased activity of MPO protein]; Curcumin inhibits the reaction [Indomethacin results in increased activity of MPO protein]; Curcumin inhibits the reaction [Methotrexate results in increased expression of MPO protein]; Curcumin inhibits the reaction [Thioacetamide results in increased expression of MPO protein]; Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased activity of MPO protein]; pomegranate fruit rind promotes the reaction [Curcumin inhibits the reaction [Thioacetamide results in increased expression of MPO protein]]
[Dexamethasone co-treated with Curcumin] inhibits the reaction [[Ovalbumin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased activity of MPO protein]; chromium mesoporphyrin inhibits the reaction [Curcumin inhibits the reaction [Lipopolysaccharides results in increased activity of MPO protein]]; Curcumin inhibits the reaction [[Ovalbumin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased activity of MPO protein]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased activity of MPO protein]; Curcumin inhibits the reaction [Paraquat results in increased expression of MPO protein]; Curcumin inhibits the reaction [sodium arsenite results in increased expression of MPO protein]
Curcumin analog results in decreased activity of MPO protein
Curcumin results in decreased activity of MPO protein

PMID:16804969 PMID:16867261 PMID:17276891 PMID:17351913 PMID:17373747 More...

NCBI chr11:87,684,610...87,695,238
Ensembl chr11:87,684,407...87,695,239

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mitochondrial ribosomal protein L1

increases expression

Curcumin results in increased expression of MRPL1 mRNA

NCBI chr 5:96,357,357...96,414,586
Ensembl chr 5:96,357,352...96,414,586

G

mitochondrial ribosomal protein L47

multiple interactions

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of MRPL47 mRNA]

NCBI chr 3:32,781,646...32,790,904
Ensembl chr 3:32,779,546...32,791,754

G

membrane-spanning 4-domains, subfamily A, member 1

decreases expression
increases expression

Curcumin results in decreased expression of MS4A1 mRNA
Curcumin results in increased expression of MS4A1 mRNA

PMID:17198877 PMID:18421014

NCBI chr19:11,227,043...11,243,513
Ensembl chr19:11,227,039...11,243,605

G

methylsterol monoxygenase 1

affects expression
decreases expression

Curcumin affects the expression of MSMO1 mRNA
Curcumin results in decreased expression of MSMO1 mRNA

NCBI chr 8:65,171,157...65,186,822
Ensembl chr 8:65,171,173...65,186,826

G

moesin

multiple interactions

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of MSN mRNA]

NCBI chr X:95,139,651...95,212,159
Ensembl chr X:95,139,648...95,212,158

G

macrophage scavenger receptor 1

multiple interactions

Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of MSR1 mRNA]; Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MSR1 mRNA]

NCBI chr 8:39,996,284...40,095,790
Ensembl chr 8:40,034,726...40,095,714

G

macrophage stimulating 1 receptor (c-met-related tyrosine kinase)

multiple interactions
decreases expression

Curcumin inhibits the reaction [RELA protein binds to MST1R promoter]; Curcumin inhibits the reaction [RELA protein results in increased expression of MST1R mRNA]
Curcumin results in decreased expression of MST1R mRNA; Curcumin results in decreased expression of MST1R protein

NCBI chr 9:107,784,057...107,797,582
Ensembl chr 9:107,784,072...107,797,582

G

metallothionein 2

multiple interactions
increases expression

Curcumin affects the reaction [Mercuric Chloride results in increased expression of MT2A mRNA]
Curcumin results in increased expression of MT2A mRNA

NCBI chr 8:94,899,246...94,900,195
Ensembl chr 8:94,899,292...94,900,196

G

mechanistic target of rapamycin kinase

decreases phosphorylation
multiple interactions
decreases expression

Curcumin results in decreased phosphorylation of MTOR protein
ATF4 inhibits the reaction [Curcumin results in decreased phosphorylation of MTOR protein]; Curcumin inhibits the reaction [Thioacetamide results in increased phosphorylation of MTOR protein]
4-phenylbutyric acid inhibits the reaction [Curcumin results in decreased phosphorylation of MTOR protein]; Curcumin analog inhibits the reaction [Oxygen deficiency results in increased phosphorylation of MTOR protein]; Curcumin inhibits the reaction [4,6-dimorpholino-N-(4-nitrophenyl)-1,3,5-triazin-2-amine results in increased phosphorylation of MTOR protein]; Curcumin inhibits the reaction [Tunicamycin results in increased expression of and results in increased phosphorylation of MTOR protein]; Curcumin promotes the reaction [Sirolimus results in decreased phosphorylation of MTOR protein]; Curcumin results in decreased expression of and results in decreased phosphorylation of MTOR protein
Curcumin analog results in decreased expression of MTOR mRNA; Curcumin results in decreased expression of MTOR mRNA

PMID:20554536 PMID:21450334 PMID:26409325 PMID:27363783 PMID:33582110 More...

NCBI chr 4:148,533,039...148,642,142
Ensembl chr 4:148,533,068...148,642,140

G

mucin 5, subtypes A and C, tracheobronchial/gastric

multiple interactions

Curcumin inhibits the reaction [o,p'-DDT results in increased expression of MUC5AC mRNA]

NCBI chr 7:141,342,695...141,372,964
Ensembl chr 7:141,342,709...141,372,968

G

mevalonate (diphospho) decarboxylase

decreases expression

Curcumin results in decreased expression of MVD mRNA

NCBI chr 8:123,160,335...123,170,161
Ensembl chr 8:123,160,340...123,170,161

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mevalonate kinase

affects expression
decreases expression

Curcumin affects the expression of MVK mRNA
Curcumin results in decreased expression of MVK mRNA

NCBI chr 5:114,582,324...114,598,652
Ensembl chr 5:114,582,330...114,598,652

G

MAX dimerization protein 1

increases expression

Curcumin results in increased expression of MXD1 mRNA

NCBI chr 6:86,624,026...86,646,099
Ensembl chr 6:86,624,024...86,646,143

G

Max dimerization protein 3

decreases expression

Curcumin results in decreased expression of MXD3 mRNA

PMID:15713895 PMID:17198877

NCBI chr13:55,472,983...55,477,937
Ensembl chr13:55,472,981...55,477,636

G

myelocytomatosis oncogene

multiple interactions
increases expression
decreases expression

[Curcumin co-treated with Doxorubicin] affects the expression of MYC mRNA; Curcumin inhibits the reaction [Paclitaxel results in increased expression of MYC protein]; Curcumin inhibits the reaction [TNF protein results in increased expression of MYC mRNA]
[Curcumin co-treated with Gemcitabine] results in decreased expression of MYC protein
Curcumin results in increased expression of MYC mRNA
Curcumin analog results in decreased expression of MYC protein; Curcumin results in decreased expression of MYC mRNA; Curcumin results in decreased expression of MYC protein

PMID:15713895 PMID:15911101 PMID:16219905 PMID:16243823 PMID:17041101 More...

NCBI chr15:61,857,190...61,862,210
Ensembl chr15:61,857,240...61,862,223

G

myeloid differentiation primary response gene 88

multiple interactions

Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of MYD88 mRNA]
Curcumin inhibits the reaction [[boldenone undecylenate results in increased abundance of boldenone] which results in increased expression of MYD88 mRNA]; Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of MYD88 protein]

PMID:19002562 PMID:23452621 PMID:34719837

NCBI chr 9:119,165,000...119,169,084
Ensembl chr 9:119,165,000...119,170,477

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myosin, heavy polypeptide 1, skeletal muscle, adult

decreases expression

Curcumin results in decreased expression of MYH1 mRNA

NCBI chr11:67,090,922...67,115,401
Ensembl chr11:67,090,878...67,115,401

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myosin, heavy polypeptide 6, cardiac muscle, alpha

decreases expression

Curcumin results in decreased expression of MYH6 mRNA

NCBI chr14:55,179,378...55,205,553
Ensembl chr14:55,179,378...55,204,384

G

myosin, heavy polypeptide 7, cardiac muscle, beta

multiple interactions
decreases expression

carboxymethyl-chitosan analog promotes the reaction [Curcumin results in decreased expression of MYH7 mRNA]; Curcumin inhibits the reaction [Caffeine results in increased expression of MYH7 mRNA]; Curcumin promotes the reaction [KN 93 inhibits the reaction [Caffeine results in increased expression of MYH7 mRNA]]; KN 93 promotes the reaction [Curcumin inhibits the reaction [Caffeine results in increased expression of MYH7 mRNA]]

PMID:25093688 PMID:26612707

NCBI chr14:55,208,141...55,232,083
Ensembl chr14:55,208,141...55,232,083

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myosin, light chain 12A, regulatory, non-sarcomeric

increases expression

Curcumin results in increased expression of MYL12A mRNA

NCBI chr17:71,300,788...71,309,528
Ensembl chr17:71,300,651...71,309,873

G

myosin, light polypeptide 4

decreases expression

Curcumin results in decreased expression of MYL4 mRNA

NCBI chr11:104,427,604...104,478,041
Ensembl chr11:104,441,489...104,486,579

G

myosin, light polypeptide 9, regulatory

multiple interactions

Curcumin inhibits the reaction [deoxynivalenol results in increased expression of MYL9 protein modified form]

NCBI chr 2:156,617,373...156,623,578
Ensembl chr 2:156,617,340...156,623,578

G

myosin, light polypeptide kinase

increases expression
multiple interactions

Curcumin results in increased expression of MYLK mRNA
Curcumin inhibits the reaction [deoxynivalenol results in increased expression of MYLK mRNA]; Curcumin inhibits the reaction [deoxynivalenol results in increased expression of MYLK protein]

PMID:21594647 PMID:35817260

NCBI chr16:34,565,569...34,822,806
Ensembl chr16:34,565,580...34,822,790

G

myosin XVIIIA

increases expression

Curcumin results in increased expression of MYO18A mRNA

NCBI chr11:77,654,066...77,756,806
Ensembl chr11:77,654,072...77,756,806

G

NLR family, apoptosis inhibitory protein 2

decreases expression
multiple interactions

Curcumin analog results in decreased expression of NAIP mRNA; Curcumin results in decreased expression of NAIP mRNA
[Curcumin co-treated with Doxorubicin] affects the expression of NAIP mRNA; [Curcumin co-treated with Oxygen deficiency] results in decreased expression of NAIP protein

PMID:15911101 PMID:17671737 PMID:19250217 PMID:23452621

NCBI chr13:100,280,571...100,338,630
Ensembl chr13:100,280,571...100,338,600

G

Nanog homeobox

multiple interactions
increases expression

2-methoxyestradiol inhibits the reaction [Curcumin results in increased expression of NANOG mRNA]
Curcumin results in increased expression of NANOG mRNA; Curcumin results in increased expression of NANOG protein

PMID:25822711 PMID:27237783

NCBI chr 6:122,684,448...122,691,592
Ensembl chr 6:122,684,448...122,691,592

G

nanos C2HC-type zinc finger 1

decreases expression

Curcumin results in decreased expression of NANOS1 mRNA

NCBI chr19:60,744,425...60,748,352
Ensembl chr19:60,744,425...60,748,352

G

neural cell adhesion molecule 1

increases expression

Curcumin results in increased expression of NCAM1 protein modified form

NCBI chr 9:49,413,434...49,710,909
Ensembl chr 9:49,413,436...49,710,225

G

nuclear receptor coactivator 1

multiple interactions

Curcumin promotes the reaction [VDR protein binds to NCOA1 protein]

NCBI chr12:4,297,362...4,569,452
Ensembl chr12:4,297,362...4,527,182

G

neurofilament, medium polypeptide

increases expression

Curcumin results in increased expression of NEFM mRNA

NCBI chr14:68,356,994...68,362,453
Ensembl chr14:68,320,039...68,362,295

G

nei endonuclease VIII-like 1 (E. coli)

multiple interactions

Curcumin inhibits the reaction [Copper binds to and results in decreased activity of NEIL1 protein]; Curcumin inhibits the reaction [Iron binds to and results in decreased activity of NEIL1 protein]

NCBI chr 9:57,050,072...57,055,973
Ensembl chr 9:57,050,084...57,055,589

G

nestin

multiple interactions
increases expression

Curcumin inhibits the reaction [bisphenol A results in decreased expression of NES mRNA]
Curcumin results in increased expression of NES mRNA

NCBI chr 3:87,878,400...87,887,758
Ensembl chr 3:87,878,385...87,887,758

G

neurogenic differentiation 1

multiple interactions
increases expression

Curcumin inhibits the reaction [bisphenol A results in decreased expression of NEUROD1 mRNA]
Curcumin results in increased expression of NEUROD1 mRNA

NCBI chr 2:79,282,981...79,286,980
Ensembl chr 2:79,282,865...79,287,095

G

neurogenin 1

multiple interactions
increases expression

Curcumin inhibits the reaction [bisphenol A results in decreased expression of NEUROG1 mRNA]
Curcumin results in increased expression of NEUROG1 mRNA

NCBI chr13:56,398,291...56,399,993
Ensembl chr13:56,398,291...56,399,976

G

nuclear factor, erythroid derived 2,-like 1

increases expression

Curcumin results in increased expression of NFE2L1 protein

NCBI chr11:96,708,239...96,720,810
Ensembl chr11:96,708,240...96,720,794

G

nuclear factor, erythroid derived 2, like 2

multiple interactions
increases expression
increases activity
decreases response to substance
decreases methylation
affects localization
increases localization

[Curcumin co-treated with Acetaminophen] results in increased expression of NFE2L2 mRNA; [Curcumin co-treated with Acetaminophen] results in increased expression of NFE2L2 protein; Curcumin inhibits the reaction [Cycloheximide inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of NFE2L2 protein]]; Curcumin inhibits the reaction [Hydrogen Peroxide results in decreased expression of NFE2L2 mRNA]; Curcumin inhibits the reaction [KEAP1 protein results in increased ubiquitination of NFE2L2 protein]; Curcumin promotes the reaction [Furazolidone results in increased expression of NFE2L2 protein]; Curcumin promotes the reaction [NFE2L2 protein binds to GSTP1 promoter]; Curcumin promotes the reaction [NFE2L2 protein results in increased expression of GSTP1 mRNA]; Curcumin promotes the reaction [quinocetone results in increased expression of NFE2L2 mRNA]; Curcumin promotes the reaction [sodium arsenite results in increased expression of NFE2L2 protein]; Curcumin results in increased expression of and affects the localization of NFE2L2 protein; NFE2L2 mutant form inhibits the reaction [Curcumin analog results in increased expression of GCLC mRNA]; NFE2L2 mutant form inhibits the reaction [Curcumin analog results in increased expression of GCLM mRNA]; NFE2L2 mutant form inhibits the reaction [Curcumin analog results in increased expression of HMOX1 mRNA]; NFE2L2 mutant form inhibits the reaction [Curcumin analog results in increased expression of HMOX1 protein]; NFE2L2 mutant form inhibits the reaction [Curcumin analog results in increased expression of NQO1 mRNA]; NFE2L2 mutant form inhibits the reaction [Curcumin analog results in increased expression of NQO1 protein]; NFE2L2 mutant form inhibits the reaction [Curcumin results in increased expression of GCLC mRNA]; NFE2L2 mutant form inhibits the reaction [Curcumin results in increased expression of GCLM mRNA]; NFE2L2 mutant form inhibits the reaction [Curcumin results in increased expression of HMOX1 mRNA]; NFE2L2 mutant form inhibits the reaction [Curcumin results in increased expression of HMOX1 protein]; NFE2L2 mutant form inhibits the reaction [Curcumin results in increased expression of NQO1 mRNA]; NFE2L2 mutant form inhibits the reaction [Curcumin results in increased expression of NQO1 protein]; NFE2L2 protein affects the reaction [[Curcumin co-treated with sodium arsenite] promotes the reaction TFEB protein]; NFE2L2 protein affects the reaction [Curcumin analog results in decreased susceptibility to Acrolein]; NFE2L2 protein affects the reaction [Curcumin promotes the reaction [sodium arsenite results in decreased expression of BCL2 protein]]; NFE2L2 protein affects the reaction [Curcumin promotes the reaction [sodium arsenite results in decreased expression of SOD2 protein]]; NFE2L2 protein affects the reaction [Curcumin promotes the reaction [sodium arsenite results in increased expression of HMOX1 protein]]; NFE2L2 protein affects the reaction [Curcumin promotes the reaction [sodium arsenite results in increased expression of LAMP1 protein]]; NFE2L2 protein affects the reaction [Curcumin promotes the reaction [sodium arsenite results in increased expression of SQSTM1 protein]]; NFE2L2 protein affects the reaction [Curcumin results in decreased susceptibility to Acrolein]
Curcumin results in increased expression of NFE2L2 mRNA; Curcumin results in increased expression of NFE2L2 protein
Curcumin analog results in increased expression of NFE2L2 protein; Curcumin results in increased expression of NFE2L2 mRNA; Curcumin results in increased expression of NFE2L2 protein; Curcumin results in increased expression of NFE2L2 protein modified form
Curcumin results in increased activity of NFE2L2 protein
NFE2L2 gene mutant form results in decreased susceptibility to Curcumin
Curcumin analog results in decreased methylation of NFE2L2 promoter
Curcumin affects the localization of NFE2L2 protein; Curcumin analog affects the localization of NFE2L2 protein
Curcumin results in increased localization of NFE2L2 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Curcumin affects the localization of NFE2L2 protein]; [Curcumin analog co-treated with APP protein modified form] results in increased expression of NFE2L2 protein; [Curcumin co-treated with APP protein modified form] results in increased expression of NFE2L2 protein; [Sitagliptin Phosphate co-treated with Curcumin] inhibits the reaction [decamethrin results in decreased expression of NFE2L2 protein]; Curcumin inhibits the reaction [Acetaminophen results in decreased expression of NFE2L2 mRNA]; Curcumin inhibits the reaction [Acetaminophen results in decreased expression of NFE2L2 protein]; Curcumin inhibits the reaction [aristolochic acid I results in decreased expression of NFE2L2 mRNA]; Curcumin inhibits the reaction [aristolochic acid I results in decreased expression of NFE2L2 protein]; Curcumin inhibits the reaction [decamethrin results in decreased expression of NFE2L2 protein]; Curcumin inhibits the reaction [Ketamine results in decreased expression of NFE2L2 mRNA]; Curcumin inhibits the reaction [Ketamine results in decreased expression of NFE2L2 protein modified form]; Curcumin inhibits the reaction [Ketamine results in decreased expression of NFE2L2 protein]; Curcumin inhibits the reaction [maleic acid affects the expression of NFE2L2 protein]; Curcumin inhibits the reaction [Paraquat results in increased expression of NFE2L2 mRNA]; Curcumin inhibits the reaction [Paraquat results in increased expression of NFE2L2 protein]; Curcumin inhibits the reaction [sodium arsenite results in decreased expression of NFE2L2 protein]; Curcumin inhibits the reaction [Streptozocin affects the localization of NFE2L2 protein]; Curcumin inhibits the reaction [Thioacetamide results in decreased expression of NFE2L2 mRNA]; Curcumin promotes the reaction [[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of NFE2L2 mRNA]; Curcumin promotes the reaction [[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of NFE2L2 protein]; Curcumin promotes the reaction [Diethylhexyl Phthalate results in increased expression of NFE2L2 mRNA]; Curcumin promotes the reaction [NFE2L2 protein binds to HMOX1 enhancer]; Curcumin results in increased expression of and affects the localization of NFE2L2 protein; NFE2L2 protein promotes the reaction [Curcumin results in increased activity of RELA protein]; NFE2L2 protein promotes the reaction [Curcumin results in increased expression of AKR1B1 mRNA]; NFE2L2 protein promotes the reaction [Curcumin results in increased expression of AKR1B1 protein]; pomegranate fruit rind promotes the reaction [Curcumin inhibits the reaction [Thioacetamide results in decreased expression of NFE2L2 mRNA]]; pyrazolanthrone inhibits the reaction [Curcumin affects the localization of NFE2L2 protein]; SB 203580 inhibits the reaction [Curcumin affects the localization of NFE2L2 protein]
Curcumin analog results in increased expression of NFE2L2 mRNA; Curcumin analog results in increased expression of NFE2L2 protein; Curcumin results in increased expression of NFE2L2 mRNA; Curcumin results in increased expression of NFE2L2 protein
[Curcumin co-treated with Acetaminophen] results in increased expression of NFE2L2 mRNA; [Curcumin co-treated with Acetaminophen] results in increased expression of NFE2L2 protein; [Curcumin co-treated with Benzo(a)pyrene] affects the localization of NFE2L2 protein; Curcumin inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of NFE2L2 protein]; Curcumin inhibits the reaction [Aflatoxin B1 results in decreased expression of NFE2L2 mRNA]; Curcumin inhibits the reaction [Aflatoxin B1 results in decreased expression of NFE2L2 protein]; Curcumin promotes the reaction [sodium arsenite results in increased expression of NFE2L2 mRNA]; Curcumin promotes the reaction [sodium arsenite results in increased expression of NFE2L2 protein]; NFE2L2 gene mutant form affects the reaction [Curcumin promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of HMOX1 protein]]; NFE2L2 gene mutant form inhibits the reaction [Curcumin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 mRNA]]; NFE2L2 gene mutant form inhibits the reaction [Curcumin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PTGS2 mRNA]]; NFE2L2 gene mutant form inhibits the reaction [Curcumin promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of HMOX1 mRNA]]; NFE2L2 gene mutant form inhibits the reaction [Curcumin results in decreased expression of CASP3 protein modified form]; NFE2L2 gene mutant form inhibits the reaction [Curcumin results in decreased expression of IL1B mRNA]; NFE2L2 gene mutant form inhibits the reaction [Curcumin results in decreased expression of IL6 mRNA]; NFE2L2 gene mutant form inhibits the reaction [Curcumin results in decreased expression of TNF mRNA]; NFE2L2 gene mutant form inhibits the reaction [Curcumin results in increased expression of BCL2 protein]; NFE2L2 gene mutant form inhibits the reaction [Curcumin results in increased expression of GCLC mRNA]; NFE2L2 gene mutant form inhibits the reaction [Curcumin results in increased expression of HMOX1 mRNA]; NFE2L2 gene mutant form inhibits the reaction [Curcumin results in increased expression of HMOX1 protein]; NFE2L2 gene mutant form inhibits the reaction [Curcumin results in increased expression of NQO1 mRNA]; NFE2L2 gene mutant form inhibits the reaction [Curcumin results in increased expression of NQO1 protein]; NFE2L2 protein affects the reaction [Curcumin results in increased expression of HMOX1 mRNA]

PMID:17449203 PMID:17535857 PMID:17640564 PMID:18006204 PMID:18321868 More...

NCBI chr 2:75,505,860...75,535,007
Ensembl chr 2:75,505,857...75,534,985

G

nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105

multiple interactions
decreases activity
decreases expression
decreases localization

Curcumin inhibits the reaction [Lipopolysaccharides promotes the reaction [NFKB1 protein binds to IL18 promoter]]; Curcumin inhibits the reaction [Oxygen deficiency affects the localization of NFKB1 protein]; Curcumin inhibits the reaction [Paclitaxel results in increased activity of NFKB1 protein]; Curcumin inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]; Curcumin inhibits the reaction [TNF protein results in increased activity of NFKB1 protein]; Curcumin results in decreased activity of [NFKB1 protein binds to RELA protein]; Dithiothreitol inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased activity of NFKB1 protein]]; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]]; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased activity of NFKB1 protein]]
Curcumin analog results in decreased activity of NFKB1 protein; Curcumin results in decreased activity of NFKB1 protein
[Zinc binds to Curcumin] which affects the expression of NFKB1 mRNA; Curcumin inhibits the reaction [Ethanol promotes the reaction [Lipopolysaccharides results in increased activity of [RELA protein binds to NFKB1 protein]]]
Curcumin inhibits the reaction [[NFKB1 protein binds to RELA protein] which results in increased expression of ABCB1B mRNA]; Curcumin inhibits the reaction [Lipopolysaccharides affects the localization of NFKB1 protein]; Curcumin inhibits the reaction [NFKB1 protein binds to RELA protein]; Curcumin inhibits the reaction [sodium arsenite results in increased expression of NFKB1 mRNA]
Curcumin results in decreased expression of NFKB1 protein
Curcumin results in decreased localization of NFKB1 protein

PMID:15489888 PMID:16023083 PMID:16173963 PMID:16219905 PMID:16243823 More...

NCBI chr 3:135,290,416...135,397,422
Ensembl chr 3:135,290,416...135,397,308

G

nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100

decreases activity

Curcumin results in decreased activity of NFKB2 protein

NCBI chr19:46,285,478...46,300,839
Ensembl chr19:46,292,759...46,300,824

G

nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha

multiple interactions
decreases phosphorylation
increases expression
decreases expression

Curcumin inhibits the reaction [Acetylmuramyl-Alanyl-Isoglutamine results in increased phosphorylation of NFKBIA protein]; Curcumin inhibits the reaction [bisphenol A results in increased expression of NFKBIA protein modified form]; Curcumin inhibits the reaction [Hydrogen Peroxide results in decreased expression of NFKBIA mRNA]; Curcumin inhibits the reaction [IL1B protein results in increased degradation of NFKBIA protein]; Curcumin inhibits the reaction [IL1B protein results in increased phosphorylation of NFKBIA protein]; Curcumin inhibits the reaction [NFKBIA protein results in increased degradation of RELA protein]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of NFKBIA mRNA]; Curcumin inhibits the reaction [Oxygen deficiency results in increased phosphorylation of NFKBIA protein]; Curcumin inhibits the reaction [Paclitaxel results in increased phosphorylation of and results in increased degradation of NFKBIA protein]; Curcumin inhibits the reaction [Sodium Fluoride results in increased degradation of NFKBIA protein]; Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased degradation of NFKBIA protein]; Curcumin inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]; Curcumin inhibits the reaction [TNF protein results in increased phosphorylation of NFKBIA protein]; NFKBIA protein affects the reaction [Curcumin results in decreased expression of CXCL1 mRNA]; NFKBIA protein affects the reaction [Curcumin results in decreased expression of CXCL2 mRNA]; NFKBIA protein inhibits the reaction [Curcumin results in decreased expression of CCN2 mRNA]
Curcumin inhibits the reaction [Fluorouracil results in decreased expression of NFKBIA protein]; Curcumin inhibits the reaction [sodium arsenite results in increased phosphorylation of NFKBIA protein]
Curcumin results in decreased phosphorylation of NFKBIA protein
Curcumin results in increased expression of NFKBIA protein
CD40 protein affects the reaction [Curcumin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein]]; Curcumin analog inhibits the reaction [Copper Sulfate results in increased expression of NFKBIA mRNA]; Curcumin inhibits the reaction [Copper Sulfate results in increased expression of NFKBIA mRNA]; Curcumin inhibits the reaction [Fructose results in increased degradation of NFKBIA protein]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased degradation of NFKBIA protein]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein]; Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased degradation of NFKBIA protein]; ICAM1 protein affects the reaction [Curcumin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein]]
Curcumin results in decreased expression of NFKBIA protein

PMID:12216086 PMID:15489888 PMID:15793857 PMID:16023083 PMID:16219905 More...

NCBI chr12:55,536,194...55,539,432
Ensembl chr12:55,536,195...55,539,432

G

nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, beta

multiple interactions

Curcumin inhibits the reaction [Lipopolysaccharides results in increased degradation of NFKBIB protein]

NCBI chr 7:28,457,676...28,466,069
Ensembl chr 7:28,457,676...28,466,937

G

nuclear transcription factor-Y alpha

decreases expression

Curcumin results in decreased expression of NFYA mRNA

NCBI chr17:48,693,917...48,716,782
Ensembl chr17:48,693,913...48,716,934

G

nerve growth factor receptor (TNFR superfamily, member 16)

decreases expression

Curcumin results in decreased expression of NGFR mRNA

NCBI chr11:95,459,644...95,478,524
Ensembl chr11:95,459,644...95,478,561

G

NHL repeat containing 2

decreases expression

Curcumin results in decreased expression of NHLRC2 mRNA

NCBI chr19:56,536,682...56,591,935
Ensembl chr19:56,536,693...56,591,935

G

NK2 homeobox 5

decreases expression

Curcumin results in decreased expression of NKX2-5 mRNA

NCBI chr17:27,057,638...27,063,962
Ensembl chr17:27,057,638...27,063,983

G

NK3 homeobox 1

decreases expression

Curcumin results in decreased expression of NKX3-1 mRNA; Curcumin results in decreased expression of NKX3-1 protein

PMID:17303007 PMID:18719366

NCBI chr14:69,428,141...69,432,107
Ensembl chr14:69,428,087...69,432,111

G

NLR family, pyrin domain containing 12

multiple interactions

Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of NLRP12 mRNA]

NCBI chr 7:3,267,317...3,298,400
Ensembl chr 7:3,267,458...3,298,370

G

NLR family, pyrin domain containing 3

multiple interactions

[Dexamethasone co-treated with Curcumin] inhibits the reaction [[Ovalbumin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of NLRP3 mRNA]; [Dexamethasone co-treated with Curcumin] inhibits the reaction [[Ovalbumin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of NLRP3 protein]; Curcumin inhibits the reaction [[Ovalbumin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of NLRP3 mRNA]; Curcumin inhibits the reaction [Aflatoxin B1 results in increased expression of NLRP3 mRNA]; Curcumin inhibits the reaction [Aflatoxin B1 results in increased expression of NLRP3 protein]

PMID:34998855 PMID:35063475

NCBI chr11:59,432,395...59,457,781
Ensembl chr11:59,432,394...59,457,782

G

NME/NM23 nucleoside diphosphate kinase 1

increases expression

Curcumin results in increased expression of NME1 mRNA

NCBI chr11:93,849,751...93,859,341
Ensembl chr11:93,847,805...93,859,347

G

N-myristoyltransferase 2

multiple interactions

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of NMT2 mRNA]

NCBI chr 2:3,285,249...3,329,914
Ensembl chr 2:3,285,249...3,329,914

G

nucleotide-binding oligomerization domain containing 1

multiple interactions

Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of NOD1 mRNA]

NCBI chr 6:54,900,927...54,949,655
Ensembl chr 6:54,900,934...54,949,597

G

nucleotide-binding oligomerization domain containing 2

multiple interactions

Curcumin inhibits the reaction [Acetylmuramyl-Alanyl-Isoglutamine promotes the reaction [NOD2 protein binds to NOD2 protein]]; Curcumin inhibits the reaction [lauric acid promotes the reaction [NOD2 protein binds to NOD2 protein]]

NCBI chr 8:89,373,943...89,415,103
Ensembl chr 8:89,373,943...89,415,102

G

nitric oxide synthase 1, neuronal

multiple interactions

Curcumin promotes the reaction [Sildenafil Citrate results in increased expression of NOS1 mRNA]
Curcumin inhibits the reaction [Cadmium Chloride results in decreased expression of NOS1 protein]

PMID:17627722 PMID:24662163

NCBI chr 5:118,004,904...118,096,905
Ensembl chr 5:117,919,097...118,096,905

G

nitric oxide synthase 2, inducible

multiple interactions
decreases activity
affects expression
affects activity

Curcumin inhibits the reaction [Paraquat results in increased expression of NOS2 mRNA]; Curcumin inhibits the reaction [quinocetone results in increased activity of NOS2 protein]; Curcumin inhibits the reaction [quinocetone results in increased expression of NOS2 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of NOS2 protein]; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased expression of NOS2 protein]]
Curcumin results in decreased activity of NOS2 protein
[Curcumin co-treated with Manganese] inhibits the reaction [Kainic Acid results in increased expression of NOS2 mRNA]; Curcumin analog inhibits the reaction [Rotenone results in increased expression of NOS2 mRNA]; Curcumin inhibits the reaction [Acetaminophen results in increased expression of NOS2 mRNA]; Curcumin inhibits the reaction [Bleomycin results in increased expression of NOS2 mRNA]; Curcumin inhibits the reaction [Bleomycin results in increased expression of NOS2 protein]; Curcumin inhibits the reaction [Dinitrochlorobenzene results in decreased expression of NOS2 protein]; Curcumin inhibits the reaction [Doxorubicin results in increased expression of NOS2 protein]; Curcumin inhibits the reaction [Kainic Acid results in increased expression of NOS2 mRNA]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; Curcumin inhibits the reaction [Sodium Selenite results in increased expression of NOS2 mRNA]; Curcumin inhibits the reaction [Sodium Selenite results in increased expression of NOS2 protein]; Curcumin inhibits the reaction [Streptozocin results in increased expression of NOS2 protein]; Curcumin inhibits the reaction [Thioacetamide results in increased expression of NOS2 protein]; pomegranate fruit rind promotes the reaction [Curcumin inhibits the reaction [Thioacetamide results in increased expression of NOS2 protein]]
Curcumin inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of NOS2 mRNA]; Curcumin inhibits the reaction [Chloranil results in increased expression of NOS2 protein]; Curcumin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 mRNA]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased activity of NOS2 protein]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; Curcumin inhibits the reaction [lipoteichoic acid results in increased expression of NOS2 protein]; NFE2L2 gene mutant form inhibits the reaction [Curcumin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 mRNA]]
Curcumin affects the expression of NOS2 mRNA
Curcumin affects the activity of NOS2 protein

PMID:7530002 PMID:12628514 PMID:16934299 PMID:17373747 PMID:17434272 More...

NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080

G

nitric oxide synthase 3, endothelial cell

multiple interactions

Curcumin inhibits the reaction [CXCL12 protein results in increased phosphorylation of NOS3 protein]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of NOS3 protein modified form]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of NOS3 protein]

PMID:18660423 PMID:23452621

NCBI chr 5:24,569,772...24,589,472
Ensembl chr 5:24,569,808...24,589,472

G

notch 1

decreases expression
multiple interactions

Curcumin results in decreased expression of NOTCH1 mRNA; Curcumin results in decreased expression of NOTCH1 protein
[Curcumin co-treated with Isoflavones] results in decreased expression of NOTCH1 protein

PMID:17927689 PMID:18640131

NCBI chr 2:26,347,914...26,393,834
Ensembl chr 2:26,347,915...26,406,675

G

NADPH oxidase 4

multiple interactions

Curcumin inhibits the reaction [Cyclosporine results in increased expression of NOX4 protein]

NCBI chr 7:86,893,638...87,047,918
Ensembl chr 7:86,895,304...87,047,918

G

NPC1 like intracellular cholesterol transporter 1

multiple interactions

Curcumin inhibits the reaction [bisphenol A results in increased expression of NPC1L1 protein]

NCBI chr11:6,161,011...6,180,245
Ensembl chr11:6,161,013...6,180,143

G

NPC intracellular cholesterol transporter 2

decreases expression

Curcumin results in decreased expression of NPC2 mRNA

NCBI chr12:84,801,333...84,819,886
Ensembl chr12:84,801,336...84,819,926

G

natriuretic peptide type A

multiple interactions
decreases expression

carboxymethyl-chitosan analog promotes the reaction [Curcumin results in decreased expression of NPPA mRNA]

NCBI chr 4:148,085,179...148,086,531
Ensembl chr 4:148,085,179...148,086,536

G

NAD(P)H dehydrogenase, quinone 1

increases expression
increases activity
multiple interactions

Curcumin results in increased expression of NQO1 mRNA; Curcumin results in increased expression of NQO1 protein
Curcumin results in increased activity of NQO1 protein
Curcumin analog results in increased expression of NQO1 mRNA; Curcumin analog results in increased expression of NQO1 protein; Curcumin results in increased expression of NQO1 mRNA; Curcumin results in increased expression of NQO1 protein
Curcumin analog inhibits the reaction [Rotenone results in decreased expression of NQO1 mRNA]; Curcumin inhibits the reaction [Acetaminophen results in decreased expression of NQO1 mRNA]; Curcumin inhibits the reaction [aristolochic acid I results in decreased expression of NQO1 mRNA]; Curcumin inhibits the reaction [aristolochic acid I results in decreased expression of NQO1 protein]; Curcumin inhibits the reaction [Ketamine results in decreased expression of NQO1 mRNA]; Curcumin inhibits the reaction [Ketamine results in decreased expression of NQO1 protein]; Curcumin inhibits the reaction [Paraquat results in increased activity of NQO1 protein]
[Curcumin co-treated with Chloranil] results in increased expression of NQO1 protein; Curcumin affects the expression of and results in increased activity of NQO1 protein; Curcumin inhibits the reaction [Aflatoxin B1 results in decreased expression of NQO1 mRNA]; Curcumin promotes the reaction [sodium arsenite results in increased expression of NQO1 protein]; NFE2L2 gene mutant form inhibits the reaction [Curcumin results in increased expression of NQO1 mRNA]; NFE2L2 gene mutant form inhibits the reaction [Curcumin results in increased expression of NQO1 protein]
Curcumin inhibits the reaction [Hydrogen Peroxide results in decreased expression of NQO1 mRNA]; NFE2L2 mutant form inhibits the reaction [Curcumin analog results in increased expression of NQO1 mRNA]; NFE2L2 mutant form inhibits the reaction [Curcumin analog results in increased expression of NQO1 protein]; NFE2L2 mutant form inhibits the reaction [Curcumin results in increased expression of NQO1 mRNA]; NFE2L2 mutant form inhibits the reaction [Curcumin results in increased expression of NQO1 protein]

PMID:12628514 PMID:17198877 PMID:17535857 PMID:18299980 PMID:18321868 More...

NCBI chr 8:108,114,856...108,139,012
Ensembl chr 8:108,114,857...108,129,838

G

nuclear receptor subfamily 1, group H, member 3

increases expression
multiple interactions

Curcumin results in increased expression of NR1H3 mRNA
Curcumin inhibits the reaction [bisphenol A results in increased expression of NR1H3 mRNA]; Curcumin inhibits the reaction [bisphenol A results in increased expression of NR1H3 protein]
[Curcumin cotreated with oxidized LDL] increases expression of Nr1h3 protein in macrophages

CTD
RGD

PMID:16713233 PMID:37701206 PMID:25064633

NCBI chr 2:91,014,406...91,033,189
Ensembl chr 2:91,014,406...91,033,179

G

nuclear receptor subfamily 1, group I, member 2

increases activity
affects expression

Curcumin results in increased activity of NR1I2 protein
Curcumin affects the expression of NR1I2 mRNA

PMID:17210444 PMID:29933105

NCBI chr16:38,068,711...38,115,211
Ensembl chr16:38,068,685...38,115,186

G

nuclear receptor subfamily 3, group C, member 1

increases expression
multiple interactions

Curcumin results in increased expression of NR3C1 mRNA
Curcumin inhibits the reaction [Dexamethasone results in increased phosphorylation of NR3C1 protein]

PMID:17022948 PMID:18483179

NCBI chr18:39,543,598...39,652,485
Ensembl chr18:39,543,598...39,652,474

G

nuclear receptor subfamily 4, group A, member 2

decreases expression

Curcumin results in decreased expression of NR4A2 mRNA

NCBI chr 2:56,996,845...57,014,152
Ensembl chr 2:56,996,842...57,014,015

G

nuclear receptor interacting protein 1

multiple interactions
decreases expression

NRIP1 mRNA alternative form inhibits the reaction [Curcumin results in increased expression of MIR532 mRNA]
Curcumin results in decreased expression of NRIP1 mRNA alternative form

NCBI chr16:76,084,291...76,170,930
Ensembl chr16:76,084,288...76,170,715

G

netrin 1

multiple interactions

Curcumin inhibits the reaction [Cadmium Chloride results in increased export of NTN1 protein]

NCBI chr11:68,100,190...68,277,652
Ensembl chr11:68,100,190...68,291,649

G

neurotrophic tyrosine kinase, receptor, type 2

multiple interactions

Curcumin inhibits the reaction [sodium arsenite results in decreased expression of NTRK2 protein]

NCBI chr13:58,954,363...59,281,782
Ensembl chr13:58,954,383...59,281,784

G

nucleoporin 98

increases expression

Curcumin results in increased expression of NUP98 mRNA

NCBI chr 7:101,768,607...101,859,359
Ensembl chr 7:101,768,605...101,859,383

G

ornithine aminotransferase

affects expression

Curcumin affects the expression of OAT mRNA

NCBI chr 7:132,159,204...132,178,127
Ensembl chr 7:132,159,207...132,178,127

G

occludin

multiple interactions

Curcumin inhibits the reaction [deoxynivalenol results in decreased expression of OCLN mRNA]; Curcumin inhibits the reaction [deoxynivalenol results in decreased expression of OCLN protein]

NCBI chr13:100,633,012...100,689,226
Ensembl chr13:100,633,015...100,689,226

G

ornithine decarboxylase, structural 1

increases expression
multiple interactions

Curcumin results in increased expression of ODC1 mRNA
Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of ODC1 protein]

PMID:12628514 PMID:17198877

NCBI chr12:17,594,906...17,601,503
Ensembl chr12:17,594,795...17,601,506

G

8-oxoguanine DNA-glycosylase 1

multiple interactions

Curcumin inhibits the reaction [Arsenic results in increased expression of OGG1 mRNA]; Curcumin inhibits the reaction [Arsenic results in increased expression of OGG1 protein]

NCBI chr 6:113,303,959...113,311,149
Ensembl chr 6:113,303,933...113,312,029

G

oxidized low density lipoprotein (lectin-like) receptor 1

multiple interactions

Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of OLR1 mRNA]

NCBI chr 6:129,456,113...129,484,312
Ensembl chr 6:129,462,207...129,484,128

G

OPA1, mitochondrial dynamin like GTPase

multiple interactions

Curcumin inhibits the reaction [Cisplatin results in decreased expression of OPA1 protein]

NCBI chr16:29,398,099...29,481,924
Ensembl chr16:29,398,152...29,473,702

G

oncostatin M receptor

multiple interactions

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of OSMR mRNA]

NCBI chr15:6,843,049...6,904,434
Ensembl chr15:6,843,058...6,904,450

G

OTU domain containing 7B

decreases expression

Curcumin results in decreased expression of OTUD7B mRNA

NCBI chr 3:96,011,759...96,068,446
Ensembl chr 3:96,011,839...96,068,446

G

phenylalanine hydroxylase

decreases expression

Curcumin results in decreased expression of PAH mRNA

NCBI chr10:87,357,657...87,419,999
Ensembl chr10:87,357,657...87,419,998

G

p21 (RAC1) activated kinase 2

decreases cleavage

Curcumin results in decreased cleavage of PAK2 protein

NCBI chr16:31,835,108...31,898,160
Ensembl chr16:31,835,108...31,898,160

G

poly (ADP-ribose) polymerase family, member 1

multiple interactions
increases expression
decreases cleavage
decreases expression
increases cleavage
increases degradation

[Curcumin co-treated with Bortezomib] results in increased cleavage of PARP1 protein; [Curcumin co-treated with Thalidomide] results in increased cleavage of PARP1 protein; arsenic trioxide promotes the reaction [Curcumin results in increased expression of PARP1 protein modified form]; Curcumin inhibits the reaction [Arsenic results in decreased expression of PARP1 mRNA]; Curcumin inhibits the reaction [Arsenic results in decreased expression of PARP1 protein]; Curcumin inhibits the reaction [Benzo(a)pyrene results in increased expression of PARP1 protein]; Curcumin inhibits the reaction [docetaxel results in increased cleavage of PARP1 protein]; Curcumin inhibits the reaction [sodium arsenite results in increased cleavage of PARP1 protein]; Curcumin promotes the reaction [arsenic trioxide results in increased expression of PARP1 protein modified form]; Curcumin promotes the reaction [arsenite results in increased expression of PARP1 protein]; Curcumin results in increased cleavage of and results in increased activity of PARP1 protein
Curcumin results in decreased cleavage of PARP1 protein
Curcumin analog results in decreased expression of PARP1 mRNA
Curcumin results in increased cleavage of PARP1 protein
carboxymethyl-chitosan analog promotes the reaction [Curcumin results in decreased cleavage of PARP1 protein]; Curcumin inhibits the reaction [AGT protein modified form results in increased cleavage of PARP1 protein]; Curcumin inhibits the reaction [Streptozocin results in increased cleavage of PARP1 protein]; Curcumin inhibits the reaction [tert-Butylhydroperoxide results in increased cleavage of PARP1 protein]
[Doxorubicin co-treated with Curcumin] results in increased cleavage of PARP1 protein; Curcumin inhibits the reaction [sodium arsenite results in increased cleavage of PARP1 protein]
Curcumin results in increased degradation of PARP1

PMID:11035063 PMID:14555224 PMID:14724571 PMID:15569404 PMID:16023083 More...

NCBI chr 1:180,396,456...180,428,564
Ensembl chr 1:180,396,489...180,428,819

G

paired box 6

multiple interactions
increases expression

Curcumin inhibits the reaction [bisphenol A results in decreased expression of PAX6 mRNA]
Curcumin results in increased expression of PAX6 mRNA

NCBI chr 2:105,499,241...105,528,755
Ensembl chr 2:105,499,245...105,527,709

G

phosphoenolpyruvate carboxykinase 1, cytosolic

decreases expression
affects expression

Curcumin results in decreased expression of PCK1 mRNA
Curcumin affects the expression of PCK1 mRNA

PMID:17198877 PMID:27208389

NCBI chr 2:172,994,866...173,001,067
Ensembl chr 2:172,994,841...173,001,066

G

proliferating cell nuclear antigen

decreases expression
multiple interactions
increases expression

Curcumin results in decreased expression of PCNA protein
[Curcumin binds to carboxymethyl-chitosan analog] inhibits the reaction [AGT protein modified form results in increased expression of PCNA protein]; [Curcumin binds to carboxymethyl-chitosan analog] which results in decreased expression of PCNA protein
[Dihydrotestosterone co-treated with Curcumin co-treated with Quercetin] results in increased expression of PCNA protein; Curcumin inhibits the reaction [bisphenol A results in increased expression of PCNA protein]
Curcumin results in increased expression of PCNA mRNA

PMID:16101141 PMID:18226269 PMID:23222814 PMID:24831732 PMID:26612707 More...

NCBI chr 2:132,091,206...132,095,100
Ensembl chr 2:132,091,082...132,095,234

G

proprotein convertase subtilisin/kexin type 9

affects expression

Curcumin affects the expression of PCSK9 mRNA

NCBI chr 4:106,299,531...106,321,522
Ensembl chr 4:106,299,526...106,321,526

G

platelet derived growth factor, B polypeptide

multiple interactions

Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of PDGFB protein]; Curcumin inhibits the reaction [PDGFB protein results in increased phosphorylation of MAPK1 protein]; Curcumin inhibits the reaction [PDGFB protein results in increased phosphorylation of MAPK3 protein]; tin protoporphyrin IX inhibits the reaction [Curcumin inhibits the reaction [PDGFB protein results in increased phosphorylation of MAPK1 protein]]; tin protoporphyrin IX inhibits the reaction [Curcumin inhibits the reaction [PDGFB protein results in increased phosphorylation of MAPK3 protein]]

PMID:18006644 PMID:18784349

NCBI chr15:79,880,066...79,899,178
Ensembl chr15:79,880,075...79,899,178

G

platelet derived growth factor receptor, beta polypeptide

increases expression
decreases phosphorylation
multiple interactions
decreases expression

Curcumin results in increased expression of PDGFRB mRNA
Curcumin results in decreased phosphorylation of PDGFRB protein
Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of PDGFRB mRNA]
Curcumin results in decreased expression of PDGFRB mRNA; Curcumin results in decreased expression of PDGFRB protein

PMID:17372590 PMID:18006644 PMID:18332871 PMID:21594647

NCBI chr18:61,178,194...61,218,139
Ensembl chr18:61,178,222...61,218,133

G

protein disulfide isomerase associated 3

increases expression

Curcumin results in increased expression of PDIA3 mRNA

NCBI chr 2:121,244,383...121,269,168
Ensembl chr 2:121,244,256...121,269,168

G

pyruvate dehydrogenase kinase, isoenzyme 1

multiple interactions
increases phosphorylation

Acetylcysteine inhibits the reaction [Curcumin results in increased phosphorylation of PDK1 protein]; Buthionine Sulfoximine promotes the reaction [Curcumin results in increased phosphorylation of PDK1 protein]; Glutathione inhibits the reaction [Curcumin results in increased phosphorylation of PDK1 protein]

NCBI chr 2:71,703,398...71,734,202
Ensembl chr 2:71,703,568...71,734,202

G

3-phosphoinositide dependent protein kinase 1

decreases phosphorylation

Curcumin results in decreased phosphorylation of PDPK1 protein

NCBI chr17:24,292,654...24,370,957
Ensembl chr17:24,292,654...24,369,898

G

podoplanin

multiple interactions

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of PDPN mRNA]

NCBI chr 4:142,993,979...143,026,134
Ensembl chr 4:142,994,001...143,026,134

G

platelet/endothelial cell adhesion molecule 1

affects expression
multiple interactions
increases expression
decreases expression

Curcumin affects the expression of PECAM1 protein
Curcumin inhibits the reaction [Particulate Matter results in increased expression of PECAM1 protein]; Curcumin inhibits the reaction [titanium dioxide results in increased expression of PECAM1 protein]
Curcumin results in increased expression of PECAM1 protein
Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of PECAM1 mRNA]; Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of PECAM1 protein]
Gemcitabine promotes the reaction [Curcumin results in decreased expression of PECAM1 protein]

PMID:17440100 PMID:17960570 PMID:23845850 PMID:29244817

NCBI chr11:106,545,039...106,606,107
Ensembl chr11:106,545,043...106,641,454

G

period circadian clock 2

increases expression

Curcumin results in increased expression of PER2 mRNA

NCBI chr 1:91,343,699...91,387,028
Ensembl chr 1:91,343,704...91,387,046

G

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4

decreases expression

Curcumin results in decreased expression of PFKFB4 mRNA

NCBI chr 9:108,817,336...108,861,302
Ensembl chr 9:108,820,846...108,861,296

G

phosphogluconate dehydrogenase

increases expression

Curcumin results in increased expression of PGD mRNA

NCBI chr 4:149,234,448...149,251,162
Ensembl chr 4:149,234,448...149,251,228

G

placental growth factor

multiple interactions

Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of PGF mRNA]

NCBI chr12:85,213,413...85,224,087
Ensembl chr12:85,213,409...85,224,564

G

phosphatidylglycerophosphate synthase 1

multiple interactions

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of PGS1 mRNA]

NCBI chr11:117,876,505...117,914,837
Ensembl chr11:117,877,118...117,914,837

G

prohibitin 1

decreases expression

Curcumin results in decreased expression of PHB1 protein

NCBI chr11:95,557,783...95,571,599
Ensembl chr11:95,557,783...95,571,599

G

phytanoyl-CoA hydroxylase

decreases expression

Curcumin results in decreased expression of PHYH mRNA

NCBI chr 2:4,923,807...4,943,554
Ensembl chr 2:4,923,830...4,943,541

G

phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha

decreases expression

Curcumin analog results in decreased expression of PIK3C2A mRNA

NCBI chr 7:115,936,500...116,042,693
Ensembl chr 7:115,936,500...116,042,684

G

phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha

decreases expression

Curcumin analog results in decreased expression of PIK3CA mRNA

NCBI chr 3:32,451,203...32,520,256
Ensembl chr 3:32,451,820...32,522,635

G

PTEN induced putative kinase 1

multiple interactions

Curcumin inhibits the reaction [Cisplatin results in increased expression of PINK1 protein]

NCBI chr 4:138,040,718...138,053,631
Ensembl chr 4:138,040,720...138,053,618

G

pirin

increases expression

Curcumin results in increased expression of PIR mRNA

NCBI chr X:163,052,427...163,156,009
Ensembl chr X:163,052,367...163,156,007

G

paired Ig-like receptor B

multiple interactions

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of LILRB3 mRNA]

NCBI chr 7:3,715,504...3,723,381
Ensembl chr 7:3,714,408...3,723,390

G

pyruvate kinase, muscle

multiple interactions

ATF4 inhibits the reaction [Curcumin results in decreased expression of PKM protein]; Curcumin inhibits the reaction [4,6-dimorpholino-N-(4-nitrophenyl)-1,3,5-triazin-2-amine results in increased phosphorylation of PKM protein]; Curcumin inhibits the reaction [Sirolimus results in increased expression of PKM protein]

NCBI chr 9:59,563,859...59,586,655
Ensembl chr 9:59,563,651...59,586,658

G

phospholipase A2, group IIA (platelets, synovial fluid)

multiple interactions

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of PLA2G2A mRNA]

NCBI chr 4:138,559,168...138,562,500
Ensembl chr 4:138,559,171...138,562,497

G

plasminogen activator, urokinase

decreases secretion
multiple interactions
increases expression
decreases expression

Curcumin results in decreased secretion of PLAU protein
Curcumin inhibits the reaction [Bleomycin results in decreased expression of PLAU mRNA]; Curcumin inhibits the reaction [Bleomycin results in decreased expression of PLAU protein]
Curcumin results in increased expression of PLAU mRNA
TNFSF10 protein promotes the reaction [Curcumin results in decreased expression of PLAU protein]

PMID:18025290 PMID:18226269 PMID:18495463 PMID:35716765

NCBI chr14:20,886,730...20,893,456
Ensembl chr14:20,886,728...20,893,453

G

plasminogen activator, urokinase receptor

increases expression
multiple interactions

Curcumin results in increased expression of PLAUR mRNA
Curcumin inhibits the reaction [Bleomycin results in decreased expression of PLAUR mRNA]; Curcumin inhibits the reaction [Bleomycin results in decreased expression of PLAUR protein]

PMID:15713895 PMID:35716765

NCBI chr 7:24,161,857...24,175,393
Ensembl chr 7:24,161,909...24,175,393

G

phospholipase C, gamma 1

multiple interactions

curcumin inhibits the reaction [azoxymethane increases activity of Plcg1 protein in colonic mucosa]

RGD

NCBI chr 2:160,573,230...160,617,680
Ensembl chr 2:160,573,220...160,617,680

G

pleckstrin homology domain containing, family H (with MyTH4 domain) member 2

increases expression

Curcumin results in increased expression of PLEKHH2 mRNA

NCBI chr17:84,819,303...84,929,571
Ensembl chr17:84,819,323...84,929,566

G

polo like kinase 1

decreases expression

Curcumin analog results in decreased expression of PLK1 mRNA

NCBI chr 7:121,758,658...121,769,107
Ensembl chr 7:121,758,662...121,769,096

G

polo like kinase 2

increases expression

Curcumin analog results in increased expression of PLK2 mRNA

NCBI chr13:110,531,578...110,537,378
Ensembl chr13:110,531,580...110,537,378

G

polo like kinase 3

increases expression

Curcumin analog results in increased expression of PLK3 mRNA

NCBI chr 4:116,985,852...116,991,244
Ensembl chr 4:116,985,852...116,991,160

G

polo like kinase 4

increases expression

Curcumin analog results in increased expression of PLK4 mRNA

NCBI chr 3:40,754,463...40,771,318
Ensembl chr 3:40,754,454...40,771,318

G

procollagen lysine, 2-oxoglutarate 5-dioxygenase 2

multiple interactions

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of PLOD2 mRNA]

NCBI chr 9:92,421,828...92,490,481
Ensembl chr 9:92,424,276...92,490,481

G

phorbol-12-myristate-13-acetate-induced protein 1

increases expression

Curcumin results in increased expression of PMAIP1 mRNA

NCBI chr18:66,591,675...66,598,629
Ensembl chr18:66,591,604...66,598,636

G

prostate transmembrane protein, androgen induced 1

decreases expression

Curcumin results in decreased expression of PMEPA1 mRNA

NCBI chr 2:173,066,251...173,118,329
Ensembl chr 2:173,066,251...173,118,326

G

polymerase (DNA directed), alpha 2

decreases expression

Curcumin results in decreased expression of POLA2 mRNA

NCBI chr19:5,990,574...6,014,266
Ensembl chr19:5,990,570...6,014,230

G

polymerase (DNA directed), beta

multiple interactions
decreases expression

Curcumin inhibits the reaction [Arsenic results in decreased expression of POLB mRNA]; Curcumin inhibits the reaction [Arsenic results in decreased expression of POLB protein]
Curcumin results in decreased expression of POLB protein

PMID:19401701 PMID:21332098

NCBI chr 8:23,118,135...23,143,482
Ensembl chr 8:23,118,142...23,143,451

G

polymerase (DNA directed), epsilon

decreases expression

Curcumin results in decreased expression of POLE mRNA

NCBI chr 5:110,434,185...110,485,319
Ensembl chr 5:110,434,172...110,485,340

G

porcupine O-acyltransferase

multiple interactions
increases expression

Curcumin inhibits the reaction [bisphenol A results in decreased expression of PORCN mRNA]
Curcumin results in increased expression of PORCN mRNA

NCBI chr X:8,060,085...8,072,794
Ensembl chr X:8,060,087...8,072,764

G

periostin, osteoblast specific factor

increases expression

Curcumin results in increased expression of POSTN mRNA

NCBI chr 3:54,266,688...54,298,462
Ensembl chr 3:54,268,530...54,298,458

G

POU domain, class 5, transcription factor 1

multiple interactions
decreases expression
increases expression

2-methoxyestradiol inhibits the reaction [Curcumin results in increased expression of POU5F1 mRNA]
Curcumin results in decreased expression of POU5F1 mRNA; Curcumin results in decreased expression of POU5F1 protein
WWTR1 protein inhibits the reaction [Curcumin results in decreased expression of POU5F1 mRNA]; WWTR1 protein inhibits the reaction [Curcumin results in decreased expression of POU5F1 protein]
Curcumin results in increased expression of POU5F1 mRNA; Curcumin results in increased expression of POU5F1 protein

PMID:25822711 PMID:27237783 PMID:33539684

NCBI chr17:35,816,929...35,821,674
Ensembl chr17:35,816,915...35,821,669

G

peroxisome proliferator activator receptor delta

decreases expression

Curcumin results in decreased expression of PPARD mRNA; Curcumin results in decreased expression of PPARD protein

NCBI chr17:28,451,715...28,520,446
Ensembl chr17:28,451,674...28,520,448

G

peroxisome proliferator activated receptor gamma

affects binding
decreases expression
increases expression
increases activity
affects localization
multiple interactions

Curcumin binds to PPARG protein
Curcumin results in decreased expression of PPARG mRNA
Curcumin results in increased expression of PPARG mRNA; Curcumin results in increased expression of PPARG protein
Curcumin results in increased activity of PPARG protein
Curcumin results in decreased expression of PPARG protein
Curcumin affects the localization of PPARG protein
Curcumin inhibits the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of PPARG mRNA]; Curcumin inhibits the reaction [butylbenzyl phthalate promotes the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of PPARG mRNA]]; Curcumin inhibits the reaction [Dietary Fats results in increased expression of PPARG mRNA]; Curcumin results in decreased expression of and results in decreased activity of PPARG protein
2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [Curcumin inhibits the reaction [Lipopolysaccharides results in decreased activity of PPARG protein]]; 2-chloro-5-nitrobenzanilide inhibits the reaction [Curcumin results in increased expression of PPARG mRNA]; 2-chloro-5-nitrobenzanilide inhibits the reaction [Curcumin results in increased expression of PPARG protein]; Buthionine Sulfoximine inhibits the reaction [Curcumin results in increased expression of PPARG mRNA]; Buthionine Sulfoximine inhibits the reaction [Curcumin results in increased expression of PPARG protein]; Curcumin inhibits the reaction [[SMAD4 protein binds to SMAD3 protein] which binds to PPARG promoter]; Curcumin inhibits the reaction [Carbon Tetrachloride results in decreased expression of PPARG mRNA]; Curcumin inhibits the reaction [EGF protein results in decreased expression of PPARG mRNA]; Curcumin inhibits the reaction [EGF protein results in decreased expression of PPARG protein]; Curcumin inhibits the reaction [Lipopolysaccharides results in decreased activity of PPARG protein]; Curcumin inhibits the reaction [TGFB1 protein results in decreased expression of PPARG mRNA]; Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of PPARG mRNA]; Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of PPARG protein]
PPARG protein promotes the reaction [Curcumin results in decreased expression of CCN2 mRNA]
Curcumin results in decreased expression of PPARG protein modified form

PMID:15486348 PMID:15713005 PMID:16782535 PMID:16959952 PMID:17372590 More...

NCBI chr 6:115,337,828...115,467,365
Ensembl chr 6:115,337,912...115,467,360

G

peroxisome proliferative activated receptor, gamma, coactivator 1 alpha

multiple interactions
increases expression

Curcumin inhibits the reaction [[Lipopolysaccharides co-treated with Tobacco Smoke Pollution] results in decreased expression of PPARGC1A mRNA]; Curcumin inhibits the reaction [[Lipopolysaccharides co-treated with Tobacco Smoke Pollution] results in decreased expression of PPARGC1A protein]; Curcumin inhibits the reaction [Potassium Dichromate results in decreased expression of PPARGC1A protein]
Curcumin results in increased expression of PPARGC1A protein

PMID:28951138 PMID:32980475

NCBI chr 5:51,611,591...52,273,316
Ensembl chr 5:51,611,592...51,725,068

G

pancreatic progenitor cell differentiation and proliferation factor

increases expression

Curcumin results in increased expression of PPDPF mRNA

NCBI chr 2:180,828,615...180,830,297
Ensembl chr 2:180,829,040...180,830,564

G

peptidylprolyl isomerase F (cyclophilin F)

increases expression

Curcumin results in increased expression of PPIF mRNA

NCBI chr14:25,693,998...25,700,892
Ensembl chr14:25,694,578...25,700,892

G

protein phosphatase 1 catalytic subunit alpha

multiple interactions

Curcumin inhibits the reaction [sodium arsenite results in increased phosphorylation of PPP1CA protein]

NCBI chr19:4,242,173...4,245,418
Ensembl chr19:4,242,064...4,245,419

G

protein phosphatase 1, regulatory inhibitor subunit 1B

multiple interactions

Curcumin inhibits the reaction [sodium arsenite results in decreased phosphorylation of PPP1R1B protein]

NCBI chr11:98,239,232...98,248,622
Ensembl chr11:98,239,230...98,248,622

G

protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform

multiple interactions

Curcumin inhibits the reaction [Hydrogen Peroxide results in decreased expression of PPP2CA mRNA]

NCBI chr11:51,989,651...52,013,576
Ensembl chr11:51,989,508...52,018,605

G

protein phosphatase 3, catalytic subunit, gamma isoform

decreases expression

Curcumin results in decreased expression of PPP3CC mRNA

NCBI chr14:70,455,314...70,526,979
Ensembl chr14:70,455,314...70,526,920

G

protein phosphatase 5, catalytic subunit

multiple interactions

Curcumin inhibits the reaction [Hydrogen Peroxide results in decreased expression of PPP5C mRNA]

NCBI chr 7:16,738,575...16,761,812
Ensembl chr 7:16,738,565...16,761,849

G

peroxiredoxin 5

multiple interactions

Curcumin inhibits the reaction [Hypochlorous Acid results in decreased activity of PRDX5 protein]

NCBI chr19:6,884,065...6,887,474
Ensembl chr19:6,884,065...6,887,474

G

protein kinase, AMP-activated, alpha 1 catalytic subunit

increases phosphorylation

Curcumin results in increased phosphorylation of PRKAA1 protein

NCBI chr15:5,172,641...5,211,380
Ensembl chr15:5,173,343...5,211,380

G

protein kinase C, alpha

multiple interactions
decreases expression

[PRKCA protein results in increased phosphorylation of CFTR protein] promotes the reaction [Curcumin results in increased activity of CFTR protein]; PRKCA protein affects the reaction [Curcumin results in increased expression of HMOX1 protein]
Curcumin analog results in decreased expression of PRKCA mRNA

PMID:17178710 PMID:18357586 PMID:26409325

NCBI chr11:107,824,213...108,237,360
Ensembl chr11:107,824,213...108,234,754

G

protein kinase C, delta

multiple interactions
affects binding
increases phosphorylation

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Curcumin results in increased phosphorylation of PRKCD protein]; Acetylcysteine inhibits the reaction [Curcumin results in increased phosphorylation of PRKCD protein]; Buthionine Sulfoximine promotes the reaction [Curcumin results in increased phosphorylation of PRKCD protein]; Curcumin inhibits the reaction [PRKCD protein results in increased expression of IVL mRNA]; Glutathione inhibits the reaction [Curcumin results in increased phosphorylation of PRKCD protein]; PRKCD protein affects the reaction [Curcumin results in increased expression of HMOX1 protein]; PRKCD protein promotes the reaction [Curcumin results in increased expression of DDIT3 mRNA]; rottlerin inhibits the reaction [Curcumin results in increased phosphorylation of PRKCD protein]; Staurosporine inhibits the reaction [Curcumin results in increased phosphorylation of PRKCD protein]; Wortmannin inhibits the reaction [Curcumin results in increased phosphorylation of PRKCD protein]
Curcumin results in increased phosphorylation of and results in increased degradation of PRKCD protein
Curcumin binds to PRKCD protein

PMID:17148446 PMID:17171638 PMID:18357586 PMID:19161989

NCBI chr14:30,317,310...30,348,637
Ensembl chr14:30,317,311...30,348,167

G

protein kinase C, epsilon

multiple interactions
decreases expression
decreases response to substance

Curcumin inhibits the reaction [PRKCE protein results in increased expression of IVL mRNA]
Curcumin analog results in decreased expression of PRKCE mRNA
PRKCE protein results in decreased susceptibility to Curcumin

PMID:14742295 PMID:17148446 PMID:26409325

NCBI chr17:86,472,631...86,965,347
Ensembl chr17:86,475,213...86,965,347

G

protein kinase C, eta

multiple interactions

Curcumin inhibits the reaction [PRKCH protein results in increased expression of IVL mRNA]

NCBI chr12:73,631,570...73,824,959
Ensembl chr12:73,631,570...73,824,959

G

protein kinase C, theta

multiple interactions

Curcumin inhibits the reaction [Fructose results in increased phosphorylation of PRKCQ protein]

NCBI chr 2:11,176,922...11,306,033
Ensembl chr 2:11,176,919...11,306,033

G

protein kinase, DNA activated, catalytic polypeptide

multiple interactions
decreases expression

Curcumin inhibits the reaction [Arsenic results in decreased expression of PRKDC mRNA]; Curcumin inhibits the reaction [Arsenic results in decreased expression of PRKDC protein]
Curcumin results in decreased expression of PRKDC mRNA

PMID:17596214 PMID:21332098

NCBI chr16:15,455,698...15,660,103
Ensembl chr16:15,455,730...15,660,099

G

parkin RBR E3 ubiquitin protein ligase

multiple interactions

Curcumin inhibits the reaction [Cisplatin results in increased expression of PRKN protein]

NCBI chr17:11,059,227...12,282,257
Ensembl chr17:11,059,271...12,282,248

G

prolactin receptor

increases expression

Curcumin results in increased expression of PRLR mRNA

NCBI chr15:10,177,324...10,349,276
Ensembl chr15:10,177,324...10,349,266

G

prominin 1

multiple interactions
decreases expression

WWTR1 protein inhibits the reaction [Curcumin results in decreased expression of PROM1 mRNA]; WWTR1 protein inhibits the reaction [Curcumin results in decreased expression of PROM1 protein]
Curcumin results in decreased expression of PROM1 mRNA; Curcumin results in decreased expression of PROM1 protein

NCBI chr 5:44,150,963...44,260,850
Ensembl chr 5:44,150,962...44,259,374

G

patched 1

multiple interactions

[Arsenic Trioxide co-treated with Curcumin] inhibits the reaction [Cisplatin results in increased expression of PTCH1 mRNA]; Curcumin inhibits the reaction [Cisplatin results in increased expression of PTCH1 mRNA]

NCBI chr13:63,656,142...63,721,274
Ensembl chr13:63,656,142...63,721,412

G

phosphatase and tensin homolog

multiple interactions

Curcumin inhibits the reaction [bisphenol A results in increased expression of PTEN protein]

NCBI chr19:32,734,977...32,803,560
Ensembl chr19:32,734,897...32,803,560

G

prostaglandin E synthase

multiple interactions

Curcumin inhibits the reaction [IL1B protein results in increased expression of PTGES protein]

NCBI chr 2:30,779,483...30,793,309
Ensembl chr 2:30,779,483...30,819,875

G

prostaglandin E synthase 2

multiple interactions

Curcumin inhibits the reaction [Benzo(a)pyrene results in increased expression of PTGES2 protein]

NCBI chr 2:32,285,902...32,292,752
Ensembl chr 2:32,285,908...32,295,784

G

prostaglandin-endoperoxide synthase 1

decreases expression

Curcumin results in decreased expression of PTGS1 mRNA

NCBI chr 2:36,106,758...36,142,287
Ensembl chr 2:36,120,438...36,142,284

G

prostaglandin-endoperoxide synthase 2

decreases expression
increases expression
multiple interactions
affects expression

Curcumin analog results in decreased expression of PTGS2 mRNA; Curcumin results in decreased expression of PTGS2 mRNA; Curcumin results in decreased expression of PTGS2 protein
Curcumin analog results in increased expression of PTGS2 mRNA
[Curcumin co-treated with Gemcitabine] results in decreased expression of PTGS2 protein; Curcumin analog inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; Curcumin inhibits the reaction [Aflatoxin B1 results in increased expression of PTGS2 mRNA]; Curcumin inhibits the reaction [Chloranil results in increased expression of PTGS2 protein]; Curcumin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PTGS2 mRNA]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]; Curcumin inhibits the reaction [lipoteichoic acid results in increased expression of PTGS2 protein]; Curcumin inhibits the reaction [TNF protein results in increased expression of PTGS2 mRNA]; Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of PTGS2 mRNA]; NFE2L2 gene mutant form inhibits the reaction [Curcumin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PTGS2 mRNA]]
Curcumin results in increased expression of PTGS2 mRNA
[Curcumin co-treated with Azoxymethane] results in increased expression of PTGS2 mRNA; [Curcumin co-treated with Manganese] inhibits the reaction [Kainic Acid results in increased expression of PTGS2 mRNA]; Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of PTGS2 mRNA]; Curcumin inhibits the reaction [Doxorubicin results in increased expression of PTGS2 protein]; Curcumin inhibits the reaction [Fructose results in increased expression of PTGS2 protein]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; Curcumin inhibits the reaction [Quartz results in increased expression of PTGS2 mRNA]; Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of PTGS2 mRNA]; Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of PTGS2 protein]; Curcumin inhibits the reaction [VIP protein results in increased expression of PTGS2 protein]
Curcumin affects the expression of PTGS2 mRNA
[Fluorouracil co-treated with Curcumin] results in decreased expression of PTGS2 protein; Curcumin inhibits the reaction [[TNF protein co-treated with IL1B protein] results in increased expression of PTGS2 protein]; Curcumin inhibits the reaction [IL1B protein results in increased expression of PTGS2 protein]; Curcumin inhibits the reaction [Nicotine results in increased expression of PTGS2 protein]; Curcumin inhibits the reaction [Paclitaxel results in increased expression of PTGS2 mRNA]; Curcumin inhibits the reaction [Paclitaxel results in increased expression of PTGS2 protein]; Curcumin inhibits the reaction [TNF protein results in increased expression of PTGS2 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]; Curcumin inhibits the reaction [TNFSF11 protein results in increased expression of PTGS2 protein]; Curcumin inhibits the reaction [Tobacco Smoke Pollution results in increased expression of PTGS2 protein]; Curcumin inhibits the reaction [VEGFA protein results in increased expression of PTGS2 mRNA]; Curcumin inhibits the reaction [VEGFA protein results in increased expression of PTGS2 protein]; Curcumin promotes the reaction [Fluorouracil results in decreased phosphorylation of and results in decreased activity of PTGS2 protein]; Curcumin promotes the reaction [Folfox protocol results in decreased phosphorylation of and results in decreased activity of PTGS2 protein]; Curcumin results in decreased phosphorylation of and results in decreased activity of PTGS2 protein; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]]; TNFSF10 protein promotes the reaction [Curcumin results in decreased expression of PTGS2 protein]

PMID:15129424 PMID:15489888 PMID:15841493 PMID:15911101 PMID:16023083 More...

NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978

G

parathyroid hormone-like peptide

multiple interactions

Curcumin inhibits the reaction [EGF protein results in increased secretion of PTHLH protein]

NCBI chr 6:147,153,607...147,165,511
Ensembl chr 6:147,153,599...147,165,681

G

protein tyrosine phosphatase, non-receptor type 13

decreases expression

Curcumin results in decreased expression of PTPN13 mRNA

NCBI chr 5:103,573,058...103,746,227
Ensembl chr 5:103,573,058...103,746,169

G

protein tyrosine phosphatase, non-receptor type 6

increases expression

Curcumin results in increased expression of PTPN6 mRNA

NCBI chr 6:124,697,670...124,715,672
Ensembl chr 6:124,697,670...124,715,677

G

protein tyrosine phosphatase, non-receptor type 7

increases expression

Curcumin results in increased expression of PTPN7 mRNA

NCBI chr 1:135,059,577...135,073,064
Ensembl chr 1:135,060,438...135,073,055

G

protein tyrosine phosphatase receptor type O

multiple interactions

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of PTPRO mRNA]

NCBI chr 6:137,229,189...137,440,251
Ensembl chr 6:137,229,317...137,440,231

G

protein tyrosine phosphatase receptor type R

decreases expression

Curcumin results in decreased expression of PTPRR mRNA

NCBI chr10:115,854,093...116,110,837
Ensembl chr10:115,854,118...116,110,837

G

pentraxin related gene

multiple interactions

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of PTX3 mRNA]

NCBI chr 3:66,127,308...66,133,227
Ensembl chr 3:66,127,331...66,133,226

G

PYD and CARD domain containing

multiple interactions

Curcumin inhibits the reaction [Aflatoxin B1 results in increased expression of PYCARD mRNA]

NCBI chr 7:127,590,545...127,593,039
Ensembl chr 7:127,588,880...127,593,039

G

RAB8A, member RAS oncogene family

decreases expression

Curcumin results in decreased expression of RAB8A mRNA

NCBI chr 8:72,915,044...72,935,210
Ensembl chr 8:72,915,044...72,937,748

G

Rac family small GTPase 1

multiple interactions

Curcumin inhibits the reaction [Doxorubicin results in increased expression of RAC1 mRNA]

NCBI chr 5:143,491,236...143,513,786
Ensembl chr 5:143,489,389...143,513,791

G

RAD51 recombinase

multiple interactions

[Mitomycin co-treated with Curcumin] results in decreased expression of RAD51 mRNA; acetylleucyl-leucyl-norleucinal inhibits the reaction [[Mitomycin co-treated with Curcumin] results in decreased expression of RAD51 mRNA]; acetylleucyl-leucyl-norleucinal inhibits the reaction [Curcumin inhibits the reaction [Mitomycin results in increased expression of RAD51 protein]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[Mitomycin co-treated with Curcumin] results in decreased expression of RAD51 mRNA]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Curcumin inhibits the reaction [Mitomycin results in increased expression of RAD51 protein]]; Curcumin inhibits the reaction [Mitomycin results in increased expression of RAD51 protein]; MAP2K1 protein inhibits the reaction [Curcumin inhibits the reaction [Mitomycin results in increased expression of RAD51 protein]]; MAP2K2 protein inhibits the reaction [Curcumin inhibits the reaction [Mitomycin results in increased expression of RAD51 protein]]; RAD51 results in decreased susceptibility to [Curcumin co-treated with Mitomycin]; U 0126 promotes the reaction [[Mitomycin co-treated with Curcumin] results in decreased expression of RAD51 mRNA]; U 0126 promotes the reaction [Curcumin inhibits the reaction [Mitomycin results in increased expression of RAD51 protein]]

NCBI chr 2:118,943,295...118,966,554
Ensembl chr 2:118,943,274...118,977,926

G

v-raf-leukemia viral oncogene 1

increases activity
multiple interactions

Curcumin results in increased activity of RAF1 protein
piperlongumine inhibits the reaction [Curcumin results in increased activity of RAF1 protein]

NCBI chr 6:115,595,530...115,653,596
Ensembl chr 6:115,595,028...115,653,596

G

receptor (calcitonin) activity modifying protein 1

decreases expression

Curcumin results in decreased expression of RAMP1 mRNA

NCBI chr 1:91,107,544...91,152,918
Ensembl chr 1:91,107,544...91,152,918

G

retinoic acid receptor, alpha

multiple interactions

Curcumin inhibits the reaction [TGFB1 protein results in increased expression of RARA mRNA]

NCBI chr11:98,818,626...98,865,768
Ensembl chr11:98,818,644...98,865,768

G

Ras association (RalGDS/AF-6) domain family member 2

increases expression

Curcumin results in increased expression of RASSF2 mRNA

NCBI chr 2:131,834,770...131,872,336
Ensembl chr 2:131,831,335...131,872,178

G

RB transcriptional corepressor 1

decreases phosphorylation
multiple interactions

Curcumin results in decreased phosphorylation of RB1 protein
Curcumin inhibits the reaction [bisphenol A results in increased phosphorylation of RB1 protein]

PMID:15738001 PMID:18156803 PMID:23222814

NCBI chr14:73,430,298...73,563,446
Ensembl chr14:73,421,113...73,563,262

G

RNA binding motif protein 39

increases expression

Curcumin results in increased expression of RBM39 mRNA

NCBI chr 2:155,989,159...156,022,649
Ensembl chr 2:155,989,159...156,022,158

G

retinol binding protein 1, cellular

multiple interactions

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of RBP1 mRNA]

NCBI chr 9:98,305,014...98,328,604
Ensembl chr 9:98,305,014...98,328,628

G

regenerating islet-derived 3 beta

multiple interactions

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of REG3A mRNA]

NCBI chr 6:78,347,868...78,350,449
Ensembl chr 6:78,347,640...78,350,449

G

regenerating islet-derived 3 delta

multiple interactions

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of REG3D mRNA]

NCBI chr 6:78,352,857...78,355,848
Ensembl chr 6:78,352,857...78,355,848

G

regenerating islet-derived 3 gamma

multiple interactions

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of REG3G mRNA]

NCBI chr 6:78,443,252...78,445,857
Ensembl chr 6:78,443,252...78,445,855

G

reticuloendotheliosis oncogene

multiple interactions
increases expression

Curcumin inhibits the reaction [Hydrogen Peroxide results in increased expression of REL mRNA]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of REL mRNA]; Curcumin promotes the reaction [Hydrogen Peroxide results in increased expression of REL protein]
Curcumin results in increased expression of REL protein

PMID:23452621 PMID:31521693

NCBI chr11:23,686,847...23,720,969
Ensembl chr11:23,686,847...23,720,970

G

v-rel reticuloendotheliosis viral oncogene homolog A (avian)

multiple interactions
decreases expression
increases activity
affects activity
increases expression
decreases localization
decreases activity

[Curcumin co-treated with Isoflavones] results in decreased activity of RELA protein; Curcumin inhibits the reaction [Acetylmuramyl-Alanyl-Isoglutamine results in increased activity of RELA protein]; Curcumin inhibits the reaction [Acetylmuramyl-Alanyl-Isoglutamine results in increased phosphorylation of and affects the localization of RELA protein]; Curcumin inhibits the reaction [Acids results in increased activity of RELA protein]; Curcumin inhibits the reaction [Acrylamide results in increased expression of RELA protein]; Curcumin inhibits the reaction [bisphenol A results in increased expression of RELA protein modified form]; Curcumin inhibits the reaction [Doxorubicin results in increased expression of RELA]; Curcumin inhibits the reaction [Formaldehyde results in increased expression of RELA protein]; Curcumin inhibits the reaction [Glucose results in increased activity of RELA protein]; Curcumin inhibits the reaction [IL1B protein results in increased localization of RELA protein]; Curcumin inhibits the reaction [IL1B protein results in increased phosphorylation of and results in increased activity of and results in increased localization of RELA protein]; Curcumin inhibits the reaction [lauric acid results in increased activity of RELA protein]; Curcumin inhibits the reaction [Lipopolysaccharides promotes the reaction [RELA protein binds to IL18 promoter]]; Curcumin inhibits the reaction [NFKBIA protein results in increased degradation of RELA protein]; Curcumin inhibits the reaction [Oxygen deficiency affects the localization of RELA protein]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of RELA mRNA]; Curcumin inhibits the reaction [Paclitaxel results in increased activity of RELA protein]; Curcumin inhibits the reaction [quinocetone results in increased expression of RELA mRNA]; Curcumin inhibits the reaction [RELA protein binds to MST1R promoter]; Curcumin inhibits the reaction [RELA protein results in increased expression of MST1R mRNA]; Curcumin inhibits the reaction [Sodium Fluoride results in increased phosphorylation of and affects the localization of RELA protein]; Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of and affects the localization of RELA protein]; Curcumin inhibits the reaction [TNF protein affects the localization of RELA protein]; Curcumin inhibits the reaction [TNF protein results in increased acetylation of RELA protein]; Curcumin inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]; Curcumin inhibits the reaction [TNF protein results in increased activity of RELA protein]; Curcumin inhibits the reaction [TNF protein results in increased localization of and results in increased activity of RELA protein]; Curcumin inhibits the reaction [TNF protein results in increased localization of RELA protein]; Curcumin inhibits the reaction [TNF protein results in increased phosphorylation of RELA protein]; Curcumin results in decreased activity of [NFKB1 protein binds to RELA protein]; Curcumin results in decreased expression of and results in decreased activity of RELA protein; Curcumin results in decreased phosphorylation of and affects the localization of RELA protein; Dithiothreitol inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased activity of RELA protein]]; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]]; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased activity of RELA protein]]; TNFSF10 protein promotes the reaction [Curcumin results in decreased activity of RELA protein]; zinc protoporphyrin inhibits the reaction [Curcumin inhibits the reaction [quinocetone results in increased expression of RELA mRNA]]
[Curcumin co-treated with Gemcitabine] results in decreased expression of RELA protein; Curcumin analog inhibits the reaction [Lipopolysaccharides affects the localization of RELA protein]; Curcumin inhibits the reaction [[NFKB1 protein binds to RELA protein] which results in increased expression of ABCB1B mRNA]; Curcumin inhibits the reaction [[Ovalbumin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of RELA protein]; Curcumin inhibits the reaction [Chloranil affects the localization of RELA protein modified form]; Curcumin inhibits the reaction [Chloranil results in increased expression of RELA protein]; Curcumin inhibits the reaction [Dibutyl Phthalate results in increased phosphorylation of RELA protein]; Curcumin inhibits the reaction [NFKB1 protein binds to RELA protein]; Curcumin inhibits the reaction [sodium arsenite results in increased expression of RELA protein]; Curcumin inhibits the reaction [TNF protein results in increased phosphorylation of RELA protein]
Curcumin results in decreased expression of RELA protein
Curcumin results in increased activity of RELA protein
2-chloro-5-nitrobenzanilide inhibits the reaction [Curcumin results in decreased expression of RELA protein]; [Curcumin binds to carboxymethyl-chitosan analog] inhibits the reaction [AGT protein modified form results in increased expression of and results in increased phosphorylation of RELA protein]; [Curcumin binds to carboxymethyl-chitosan analog] which results in decreased expression of and results in decreased phosphorylation of RELA protein; CD40 protein affects the reaction [Curcumin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of RELA protein]]; Curcumin inhibits the reaction [[boldenone undecylenate results in increased abundance of boldenone] which results in increased expression of RELA protein]; Curcumin inhibits the reaction [[Copper Sulfate results in increased abundance of Copper] which results in increased expression of RELA protein]; Curcumin inhibits the reaction [Doxorubicin results in increased expression of RELA protein]; Curcumin inhibits the reaction [Ethanol promotes the reaction [Lipopolysaccharides results in increased activity of [RELA protein binds to NFKB1 protein]]]; Curcumin inhibits the reaction [Lipopolysaccharides affects the localization of RELA protein]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased activity of RELA protein]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of RELA protein]; Curcumin inhibits the reaction [Streptozocin affects the localization of RELA protein]; Curcumin inhibits the reaction [Thioacetamide results in increased expression of RELA protein]; Curcumin results in increased expression of and results in increased activity of RELA protein; ICAM1 protein affects the reaction [Curcumin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of RELA protein]]; NFE2L2 protein promotes the reaction [Curcumin results in increased activity of RELA protein]; pomegranate fruit rind promotes the reaction [Curcumin inhibits the reaction [Thioacetamide results in increased expression of RELA protein]]
Curcumin affects the activity of RELA protein
Curcumin results in increased expression of RELA
Curcumin results in decreased localization of RELA protein
Curcumin results in decreased expression of RELA; Curcumin results in decreased expression of RELA mRNA; Curcumin results in decreased expression of RELA protein

PMID:12216086 PMID:12388107 PMID:15489888 PMID:15911101 PMID:16023083 More...

NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158

G

avian reticuloendotheliosis viral (v-rel) oncogene related B

multiple interactions

Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of RELB mRNA]

NCBI chr 7:19,340,142...19,363,352
Ensembl chr 7:19,340,142...19,363,363

G

reelin

multiple interactions
increases expression

Curcumin inhibits the reaction [bisphenol A results in decreased expression of RELN mRNA]
Curcumin results in increased expression of RELN mRNA

NCBI chr 5:22,089,452...22,549,703
Ensembl chr 5:22,089,452...22,549,700

G

resistin like beta

multiple interactions

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of RETNLB mRNA]

NCBI chr16:48,637,219...48,639,255
Ensembl chr16:48,637,219...48,639,255

G

REV3 like, DNA directed polymerase zeta catalytic subunit

increases expression

Curcumin results in increased expression of REV3L protein

NCBI chr10:39,607,557...39,751,207
Ensembl chr10:39,608,114...39,751,207

G

regulatory factor X-associated protein

decreases expression

Curcumin results in decreased expression of RFXAP mRNA

NCBI chr 3:54,710,536...54,715,212
Ensembl chr 3:54,710,536...54,715,212

G

regulator of G-protein signaling 16

increases expression

Curcumin results in increased expression of RGS16 mRNA

NCBI chr 1:153,616,099...153,621,212
Ensembl chr 1:153,616,095...153,621,214

G

regulator of G-protein signaling 4

decreases expression

Curcumin results in decreased expression of RGS4 mRNA

NCBI chr 1:169,569,046...169,575,211
Ensembl chr 1:169,569,046...169,575,211

G

regulator of G protein signaling 7

decreases expression

Curcumin results in decreased expression of RGS7 mRNA

NCBI chr 1:174,886,642...175,320,287
Ensembl chr 1:174,886,653...175,320,066

G

ras homolog family member A

decreases expression

Curcumin analog results in decreased expression of RHOA mRNA

NCBI chr 9:108,183,359...108,215,142
Ensembl chr 9:108,183,328...108,215,133

G

ras homolog family member B

decreases expression

Curcumin analog results in decreased expression of RHOB mRNA

NCBI chr12:8,547,661...8,550,009
Ensembl chr12:8,547,661...8,550,009

G

regulating synaptic membrane exocytosis 2

decreases expression

Curcumin results in decreased expression of RIMS2 mRNA

NCBI chr15:39,061,681...39,547,768
Ensembl chr15:39,061,656...39,547,768

G

receptor (TNFRSF)-interacting serine-threonine kinase 1

multiple interactions

Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of RIPK1 mRNA]

NCBI chr13:34,181,072...34,219,153
Ensembl chr13:34,186,346...34,221,130

G

ribosomal protein L31

increases expression

Curcumin results in increased expression of RPL31 mRNA

NCBI chr 1:39,406,987...39,410,992
Ensembl chr 1:39,406,923...39,410,992

G

ribosomal protein S6

multiple interactions
decreases phosphorylation

calyculin A inhibits the reaction [Curcumin results in decreased phosphorylation of RPS6 protein]; Curcumin inhibits the reaction [bisphenol A results in increased phosphorylation of and results in increased expression of RPS6 protein]; Curcumin results in decreased phosphorylation of and results in decreased expression of RPS6 protein

PMID:18790744 PMID:21450334 PMID:23222814 PMID:34634291

NCBI chr 4:86,772,336...86,775,604
Ensembl chr 4:86,772,897...86,775,649

G

ribosomal protein S6 kinase, polypeptide 1

decreases phosphorylation
multiple interactions

Curcumin results in decreased phosphorylation of RPS6KB1 protein
Curcumin inhibits the reaction [Thioacetamide results in increased phosphorylation of RPS6KB1 protein]
Curcumin analog inhibits the reaction [Oxygen deficiency results in increased phosphorylation of RPS6KB1 protein]

PMID:18790744 PMID:20554536 PMID:27363783 PMID:34634291

NCBI chr11:86,389,695...86,435,711
Ensembl chr11:86,389,697...86,435,631

G

ras responsive element binding protein 1

multiple interactions

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of RREB1 mRNA]

NCBI chr13:37,962,362...38,135,981
Ensembl chr13:37,962,376...38,135,981

G

rhotekin

multiple interactions

Curcumin inhibits the reaction [RTKN protein results in decreased susceptibility to Butyrates]; Curcumin inhibits the reaction [RTKN protein results in decreased susceptibility to Fluorouracil]; Curcumin inhibits the reaction [RTKN protein results in decreased susceptibility to Paclitaxel]

NCBI chr 6:83,112,485...83,129,560
Ensembl chr 6:83,112,444...83,129,560

G

runt related transcription factor 2

decreases expression

Curcumin results in decreased expression of RUNX2 protein

NCBI chr17:44,806,873...45,125,518
Ensembl chr17:44,806,874...45,125,684

G

retinoid X receptor alpha

multiple interactions

Curcumin promotes the reaction [VDR protein binds to RXRA protein]

NCBI chr 2:27,566,457...27,653,331
Ensembl chr 2:27,566,452...27,652,969

G

S100 calcium binding protein A8 (calgranulin A)

multiple interactions

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of S100A8 mRNA]

NCBI chr 3:90,576,378...90,577,341
Ensembl chr 3:90,576,285...90,577,342

G

S100 calcium binding protein A9 (calgranulin B)

multiple interactions

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of S100A9 mRNA]

NCBI chr 3:90,599,937...90,603,028
Ensembl chr 3:90,599,939...90,603,028

G

S100 calcium binding protein G

affects expression

Curcumin affects the expression of S100G mRNA

NCBI chr X:161,744,988...161,747,595
Ensembl chr X:161,744,988...161,747,595

G

scavenger receptor class B, member 1

affects expression

Curcumin affects the expression of SCARB1 mRNA

NCBI chr 5:125,354,151...125,418,082
Ensembl chr 5:125,354,151...125,418,158

G

stearoyl-Coenzyme A desaturase 1

decreases expression
affects expression

Curcumin results in decreased expression of SCD mRNA
Curcumin affects the expression of SCD1 mRNA; Curcumin affects the expression of SCD1 protein

NCBI chr19:44,382,889...44,396,148
Ensembl chr19:44,382,894...44,396,318

G

stearoyl-Coenzyme A desaturase 2

decreases expression

Curcumin results in decreased expression of SCD2 mRNA
Curcumin results in decreased expression of SCD mRNA

PMID:20816778 PMID:27208389

NCBI chr19:44,282,115...44,295,303
Ensembl chr19:44,282,113...44,295,303

G

secernin 2

decreases expression

Curcumin results in decreased expression of SCRN2 mRNA

NCBI chr11:96,920,717...96,924,786
Ensembl chr11:96,920,764...96,924,784

G

succinate dehydrogenase complex, subunit A, flavoprotein (Fp)

decreases expression

Curcumin results in decreased expression of SDHA mRNA

NCBI chr13:74,470,374...74,498,359
Ensembl chr13:74,470,373...74,498,399

G

selectin, endothelial cell

multiple interactions
affects expression

Curcumin inhibits the reaction [F2 protein results in increased expression of SELE protein]; Curcumin inhibits the reaction [TNF protein results in increased expression of SELE protein]
Curcumin inhibits the reaction [Particulate Matter results in increased expression of SELE protein]; Curcumin inhibits the reaction [titanium dioxide results in increased expression of SELE protein]
Curcumin affects the expression of SELE protein

PMID:17960570 PMID:18565277 PMID:29244817

NCBI chr 1:163,867,200...163,886,056
Ensembl chr 1:163,875,773...163,885,246

G

selectin, lymphocyte

multiple interactions

Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of SELL mRNA]

NCBI chr 1:163,889,556...163,908,354
Ensembl chr 1:163,889,551...163,911,750

G

selectin, platelet

multiple interactions

Curcumin inhibits the reaction [F2 protein results in increased expression of SELP protein]; Curcumin inhibits the reaction [TNF protein results in increased expression of SELP protein]
Curcumin inhibits the reaction [Particulate Matter results in increased expression of SELP protein]; Curcumin inhibits the reaction [titanium dioxide results in increased expression of SELP protein]

PMID:18565277 PMID:29244817

NCBI chr 1:163,942,833...163,977,595
Ensembl chr 1:163,942,833...163,977,595

G

septin 7

increases expression

Curcumin results in increased expression of SEPTIN7 mRNA

NCBI chr 9:25,163,287...25,219,867
Ensembl chr 9:25,163,735...25,219,867

G

serine (or cysteine) peptidase inhibitor, clade A, member 3B

multiple interactions

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of SERPINA3 mRNA]

NCBI chr12:104,094,245...104,105,805
Ensembl chr12:104,094,255...104,105,804

G

serine (or cysteine) peptidase inhibitor, clade B, member 2

increases expression

Curcumin results in increased expression of SERPINB2 mRNA

NCBI chr 1:107,439,153...107,453,330
Ensembl chr 1:107,439,153...107,463,208

G

serine (or cysteine) peptidase inhibitor, clade B, member 5

increases expression
multiple interactions

[Curcumin results in increased expression of SERPINB5] which results in increased expression of TP53 protein; Curcumin results in increased expression of SERPINB5 mRNA; Curcumin results in increased expression of SERPINB5 protein
[Curcumin results in increased expression of SERPINB5] which results in decreased expression of BCL2 protein

PMID:17290611 PMID:19944674

NCBI chr 1:106,788,905...106,811,078
Ensembl chr 1:106,788,903...106,811,078

G

serine (or cysteine) peptidase inhibitor, clade E, member 1

increases expression
multiple interactions

Curcumin results in increased expression of SERPINE1 mRNA
Curcumin inhibits the reaction [Bleomycin results in increased expression of SERPINE1 mRNA]; Curcumin inhibits the reaction [Bleomycin results in increased expression of SERPINE1 protein]

PMID:15713895 PMID:35716765

NCBI chr 5:137,090,358...137,101,126
Ensembl chr 5:137,090,358...137,101,122

G

serine (or cysteine) peptidase inhibitor, clade E, member 2

multiple interactions

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of SERPINE2 mRNA]

NCBI chr 1:79,772,038...79,836,382
Ensembl chr 1:79,771,914...79,838,897

G

serine (or cysteine) peptidase inhibitor, clade H, member 1

multiple interactions

Curcumin inhibits the reaction [Thioacetamide results in increased expression of SERPINH1 mRNA]

NCBI chr 7:98,994,583...99,002,321
Ensembl chr 7:98,994,583...99,002,446

G

splicing factor proline/glutamine rich (polypyrimidine tract binding protein associated)

increases expression

Curcumin results in increased expression of SFPQ mRNA

NCBI chr 4:126,914,504...126,944,894
Ensembl chr 4:126,915,117...126,930,806

G

secreted frizzled-related protein 2

decreases expression
multiple interactions

Curcumin results in decreased expression of SFRP2 mRNA
Curcumin inhibits the reaction [bisphenol A results in increased expression of SFRP2 mRNA]

NCBI chr 3:83,673,628...83,681,621
Ensembl chr 3:83,673,628...83,681,623

G

secreted frizzled-related sequence protein 5

decreases expression

Curcumin results in decreased expression of SFRP5 mRNA

NCBI chr19:42,186,410...42,190,691
Ensembl chr19:42,186,410...42,190,691

G

sideroflexin 1

decreases expression

Curcumin results in decreased expression of SFXN1 mRNA

NCBI chr13:54,225,675...54,262,365
Ensembl chr13:54,225,888...54,262,361

G

sonic hedgehog

multiple interactions

[Arsenic Trioxide co-treated with Curcumin] inhibits the reaction [Cisplatin results in increased expression of SHH mRNA]; Curcumin inhibits the reaction [Cisplatin results in increased expression of SHH mRNA]

NCBI chr 5:28,661,838...28,672,099
Ensembl chr 5:28,661,813...28,672,254

G

single-minded family bHLH transcription factor 2

multiple interactions

Curcumin inhibits the reaction [Glucose results in increased expression of SIM2 mRNA]; Curcumin inhibits the reaction [Glucose results in increased expression of SIM2 protein]

NCBI chr16:93,885,963...93,927,891
Ensembl chr16:93,885,790...93,927,891

G

sirtuin 1

increases expression
multiple interactions

Curcumin results in increased expression of SIRT1 mRNA
Curcumin inhibits the reaction [aristolochic acid I results in decreased expression of SIRT1 mRNA]; Curcumin inhibits the reaction [aristolochic acid I results in decreased expression of SIRT1 protein]; Curcumin inhibits the reaction [Cyclosporine results in decreased expression of SIRT1 protein]

PMID:18403477 PMID:32569592 PMID:36037877

NCBI chr10:63,154,784...63,174,814
Ensembl chr10:63,154,784...63,217,483

G

sirtuin 3

multiple interactions

Curcumin inhibits the reaction [[Lipopolysaccharides co-treated with Tobacco Smoke Pollution] results in decreased expression of SIRT3 mRNA]; Curcumin inhibits the reaction [[Lipopolysaccharides co-treated with Tobacco Smoke Pollution] results in decreased expression of SIRT3 protein]; Curcumin inhibits the reaction [Cisplatin results in decreased expression of and results in decreased activity of SIRT3 protein]
Curcumin inhibits the reaction [[GYY 4137 results in increased abundance of Hydrogen Sulfide] inhibits the reaction [Hydrogen Peroxide results in decreased expression of SIRT3 mRNA]]

PMID:26422756 PMID:28698153 PMID:28951138

NCBI chr 7:140,443,576...140,462,222
Ensembl chr 7:140,443,579...140,462,222

G

sirtuin 6

multiple interactions

Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in decreased expression of SIRT6 mRNA]; Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in decreased expression of SIRT6 protein]; SIRT6 protein promotes the reaction [Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in decreased expression of ABCA1 mRNA]]; SIRT6 protein promotes the reaction [Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in decreased expression of ABCA1 protein]]; SIRT6 protein promotes the reaction [Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of CCL2 protein]]; SIRT6 protein promotes the reaction [Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of IL6 protein]]; SIRT6 protein promotes the reaction [Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of TNF protein]]

NCBI chr10:81,457,621...81,463,631
Ensembl chr10:81,457,619...81,463,631

G

sirtuin 7

decreases expression

Curcumin results in decreased expression of SIRT7

NCBI chr11:120,509,197...120,515,840
Ensembl chr11:120,509,198...120,516,066

G

src family associated phosphoprotein 2

decreases expression

Curcumin results in decreased expression of SKAP2 mRNA

NCBI chr 6:51,836,145...51,989,529
Ensembl chr 6:51,834,402...51,989,529

G

solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2

increases expression

Curcumin results in increased expression of SLC11A2 mRNA

NCBI chr15:100,285,779...100,322,090
Ensembl chr15:100,285,779...100,322,953

G

solute carrier family 16 (monocarboxylic acid transporters), member 1

decreases expression

Curcumin results in decreased expression of SLC16A1 protein

NCBI chr 3:104,545,980...104,565,778
Ensembl chr 3:104,545,984...104,565,778

G

solute carrier family 18 (vesicular monoamine), member 2

multiple interactions

Curcumin inhibits the reaction [sodium arsenite results in decreased expression of SLC18A2 protein]

NCBI chr19:59,249,310...59,284,444
Ensembl chr19:59,249,328...59,284,444

G

solute carrier family 1 (glial high affinity glutamate transporter), member 3

multiple interactions

Curcumin inhibits the reaction [Streptozocin results in decreased expression of SLC1A3 mRNA]

NCBI chr15:8,663,608...8,742,648
Ensembl chr15:8,663,608...8,740,248

G

solute carrier family 20, member 1

multiple interactions

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of SLC20A1 mRNA]

NCBI chr 2:129,038,662...129,053,535
Ensembl chr 2:129,040,684...129,053,536

G

solute carrier family 2 (facilitated glucose transporter), member 1

decreases expression
multiple interactions

Curcumin results in decreased expression of SLC2A1 mRNA
Curcumin results in decreased expression of SLC2A1 protein
ATF4 inhibits the reaction [Curcumin results in decreased expression of SLC2A1 protein]; Curcumin inhibits the reaction [4,6-dimorpholino-N-(4-nitrophenyl)-1,3,5-triazin-2-amine results in increased phosphorylation of SLC2A1 protein]

PMID:21397623 PMID:36640941

NCBI chr 4:118,966,001...118,994,527
Ensembl chr 4:118,965,908...118,995,180

G

solute carrier family 2 (facilitated glucose transporter), member 2

decreases expression
multiple interactions

Curcumin results in decreased expression of SLC2A2 mRNA
Curcumin inhibits the reaction [Streptozocin results in decreased expression of SLC2A2 protein]

PMID:21397623 PMID:25541178

NCBI chr 3:28,752,052...28,782,510
Ensembl chr 3:28,752,052...28,785,508

G

solute carrier family 2 (facilitated glucose transporter), member 3

decreases expression

Curcumin results in decreased expression of SLC2A3 mRNA

NCBI chr 6:122,704,783...122,779,149
Ensembl chr 6:122,704,768...122,778,599

G

solute carrier family 2 (facilitated glucose transporter), member 5

decreases expression

Curcumin results in decreased expression of SLC2A5 mRNA

NCBI chr 4:150,203,801...150,228,625
Ensembl chr 4:150,203,740...150,228,626

G

solute carrier family 30 (zinc transporter), member 1

increases expression

Curcumin results in increased expression of SLC30A1 mRNA

NCBI chr 1:191,638,810...191,645,359
Ensembl chr 1:191,638,879...191,645,359

G

solute carrier family 30, member 10

multiple interactions

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of SLC30A10 mRNA]

NCBI chr 1:185,187,045...185,200,959
Ensembl chr 1:185,187,045...185,200,959

G

solute carrier family 37 (glucose-6-phosphate transporter), member 4

decreases expression

Curcumin results in decreased expression of SLC37A4 mRNA

NCBI chr 9:44,308,243...44,314,263
Ensembl chr 9:44,308,149...44,314,265

G

solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2

increases expression

Curcumin results in increased expression of SLC3A2 mRNA

PMID:17198877 PMID:19183254

NCBI chr19:8,684,931...8,700,733
Ensembl chr19:8,684,246...8,700,733

G

solute carrier family 48 (heme transporter), member 1

increases expression

Curcumin results in increased expression of SLC48A1 mRNA

NCBI chr15:97,682,246...97,690,573
Ensembl chr15:97,676,401...97,690,573

G

solute carrier family 6 (neurotransmitter transporter, dopamine), member 3

multiple interactions

Curcumin inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of SLC6A3 protein]

NCBI chr13:73,684,270...73,726,791
Ensembl chr13:73,684,866...73,726,791

G

solute carrier family 7 (cationic amino acid transporter, y+ system), member 11

increases expression

Curcumin results in increased expression of SLC7A11 mRNA

PMID:17999991 PMID:19183254

NCBI chr 3:50,319,385...50,403,947
Ensembl chr 3:49,846,975...50,398,063

G

solute carrier organic anion transporter family, member 1a5

increases expression

Curcumin results in increased expression of SLCO1A2 mRNA

NCBI chr 6:142,179,953...142,268,707
Ensembl chr 6:142,179,953...142,268,707

G

secretory leukocyte peptidase inhibitor

multiple interactions

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of SLPI mRNA]

NCBI chr 2:164,195,990...164,231,086
Ensembl chr 2:164,195,990...164,231,015

G

SMAD family member 2

multiple interactions

Curcumin inhibits the reaction [AGT protein results in increased phosphorylation of SMAD2 protein]

NCBI chr18:76,369,898...76,444,819
Ensembl chr18:76,374,651...76,444,034

G

SMAD family member 3

multiple interactions

Curcumin inhibits the reaction [[SMAD4 protein binds to SMAD3 protein] which binds to PPARG promoter]; Curcumin inhibits the reaction [AGT protein results in increased phosphorylation of SMAD3 protein]; Curcumin inhibits the reaction [Thioacetamide results in increased phosphorylation of SMAD3 protein]; pomegranate fruit rind promotes the reaction [Curcumin inhibits the reaction [Thioacetamide results in increased phosphorylation of SMAD3 protein]]

PMID:16959952 PMID:26648693 PMID:32718261

NCBI chr 9:63,554,048...63,665,276
Ensembl chr 9:63,554,049...63,665,276

G

SMAD family member 4

multiple interactions
decreases expression

Curcumin inhibits the reaction [[SMAD4 protein binds to SMAD3 protein] which binds to PPARG promoter]
Curcumin results in decreased expression of SMAD4 mRNA

PMID:16959952 PMID:27237783

NCBI chr18:73,767,861...73,836,862
Ensembl chr18:73,772,080...73,836,851

G

smoothened, frizzled class receptor

multiple interactions

[Arsenic Trioxide co-treated with Curcumin] inhibits the reaction [Cisplatin results in increased expression of SMO mRNA]; Curcumin inhibits the reaction [Cisplatin results in increased expression of SMO mRNA]

NCBI chr 6:29,735,480...29,761,359
Ensembl chr 6:29,735,502...29,761,364

G

small muscle protein, X-linked

multiple interactions

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of SMPX mRNA]

NCBI chr X:156,481,969...156,535,587
Ensembl chr X:156,481,906...156,535,587

G

snail family zinc finger 1

multiple interactions

Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of SNAI1 protein]; Curcumin inhibits the reaction [Trichloroethylene results in increased expression of SNAI1 protein]

PMID:25656647 PMID:34233590

NCBI chr 2:167,380,115...167,384,734
Ensembl chr 2:167,380,115...167,384,734

G

snail family zinc finger 2

decreases expression

Curcumin results in decreased expression of SNAI2 protein

NCBI chr16:14,523,716...14,527,259
Ensembl chr16:14,523,716...14,527,249

G

synuclein, alpha

multiple interactions

[Curcumin co-treated with Niacin co-treated with ZM 241385] inhibits the reaction [Rotenone results in increased expression of SNCA protein]; Curcumin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of SNCA protein]; Curcumin inhibits the reaction [Rotenone results in increased expression of SNCA protein]

PMID:31187328 PMID:31820278

NCBI chr 6:60,708,557...60,806,839
Ensembl chr 6:60,708,559...60,806,839

G

small nucleolar RNA host gene 12

decreases expression

Curcumin results in decreased expression of SNHG12 mRNA

NCBI chr 4:132,035,989...132,038,335
Ensembl chr 4:132,035,932...132,038,762

G

suppressor of cytokine signaling 3

decreases expression

Curcumin results in decreased expression of SOCS3 mRNA

PMID:18403477 PMID:25822711

NCBI chr11:117,856,905...117,860,192
Ensembl chr11:117,856,905...117,860,873

G

suppressor of cytokine signaling 5

decreases expression

Curcumin results in decreased expression of SOCS5 protein

NCBI chr17:87,414,707...87,445,153
Ensembl chr17:87,415,107...87,445,267

G

superoxide dismutase 1, soluble

multiple interactions
increases expression

[Curcumin co-treated with Vitamin E] inhibits the reaction [Thyroxine results in decreased expression of SOD1 mRNA]; [Curcumin co-treated with Vitamin E] inhibits the reaction [Thyroxine results in increased activity of SOD1 protein]; [Curcumin co-treated with Vitamin E] promotes the reaction [Thyroxine results in decreased activity of SOD1 protein]; Curcumin inhibits the reaction [aristolochic acid I results in decreased activity of SOD1 protein]; Curcumin inhibits the reaction [Thyroxine results in decreased expression of SOD1 mRNA]; Curcumin inhibits the reaction [Thyroxine results in increased activity of SOD1 protein]; Curcumin promotes the reaction [Thyroxine results in decreased activity of SOD1 protein]
Curcumin results in increased expression of SOD1 protein
Curcumin inhibits the reaction [Hydrogen Peroxide results in decreased expression of SOD1 mRNA]; Curcumin inhibits the reaction [Hypochlorous Acid results in increased activity of SOD1 protein]; Curcumin inhibits the reaction [quinocetone results in decreased activity of SOD1 protein]
Curcumin inhibits the reaction [Aflatoxin B1 results in decreased expression of SOD1 mRNA]; Curcumin inhibits the reaction [deoxynivalenol results in decreased expression of SOD1 mRNA]; Curcumin inhibits the reaction [sodium arsenite results in decreased expression of SOD1 mRNA]

PMID:19914224 PMID:25996037 PMID:30934151 PMID:31521693 PMID:35063475 More...

NCBI chr16:90,017,650...90,023,221
Ensembl chr16:90,017,642...90,023,217

G

superoxide dismutase 2, mitochondrial

affects expression
increases expression
multiple interactions

Curcumin affects the expression of SOD2 mRNA; Curcumin affects the expression of SOD2 protein
Curcumin results in increased expression of SOD2 protein
Curcumin results in increased expression of SOD2 mRNA; Curcumin results in increased expression of SOD2 protein
2-methoxyestradiol inhibits the reaction [Curcumin results in increased expression of SOD2 mRNA]
Curcumin analog inhibits the reaction [[Sodium Cholate co-treated with Deoxycholic Acid co-treated with Glycocholic Acid co-treated with Taurocholic Acid] results in decreased expression of and results in decreased activity of SOD2 protein]; Curcumin analog inhibits the reaction [[Sodium Cholate co-treated with Deoxycholic Acid co-treated with Glycocholic Acid co-treated with Taurocholic Acid] results in increased expression of and results in decreased activity of SOD2 protein]; Curcumin analog promotes the reaction [[Sodium Cholate co-treated with Deoxycholic Acid co-treated with Glycocholic Acid co-treated with Taurocholic Acid] results in increased expression of SOD2 protein]; Curcumin inhibits the reaction [Hydrogen Peroxide results in decreased expression of SOD2 mRNA]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of SOD2 protein]; Curcumin promotes the reaction [sodium arsenite results in decreased expression of SOD2 protein]; NFE2L2 protein affects the reaction [Curcumin promotes the reaction [sodium arsenite results in decreased expression of SOD2 protein]]
[Vitamin E co-treated with Curcumin] inhibits the reaction [Thyroxine results in decreased expression of SOD2 mRNA]; Curcumin inhibits the reaction [[Lipopolysaccharides co-treated with Tobacco Smoke Pollution] results in decreased activity of SOD2 protein]; Curcumin inhibits the reaction [Thyroxine results in decreased activity of SOD2 protein]; Curcumin promotes the reaction [Thyroxine results in increased expression of SOD2 protein]

PMID:11543823 PMID:18299980 PMID:19914224 PMID:22316666 PMID:23452621 More...

NCBI chr17:13,226,726...13,237,006
Ensembl chr17:13,225,733...13,258,950

G

SRY (sex determining region Y)-box 2

increases expression

Curcumin results in increased expression of SOX2 mRNA; Curcumin results in increased expression of SOX2 protein

NCBI chr 3:34,704,144...34,706,610
Ensembl chr 3:34,704,554...34,706,610

G

SRY (sex determining region Y)-box 9

multiple interactions
increases expression

[Curcumin co-treated with resveratrol] results in increased expression of SOX9 protein
Curcumin results in increased expression of SOX9 protein

NCBI chr11:112,673,036...112,678,583
Ensembl chr11:112,673,050...112,678,586

G

trans-acting transcription factor 1

decreases expression

Curcumin results in decreased expression of SP1 protein

PMID:18347134 PMID:18593936

NCBI chr15:102,314,751...102,344,839
Ensembl chr15:102,314,578...102,344,839

G

trans-acting transcription factor 3

decreases expression

Curcumin results in decreased expression of SP3 protein

NCBI chr 2:72,766,774...72,810,790
Ensembl chr 2:72,766,771...72,810,790

G

trans-acting transcription factor 4

decreases expression

Curcumin results in decreased expression of SP4 protein

NCBI chr12:118,195,421...118,265,211
Ensembl chr12:118,198,668...118,265,175

G

secreted acidic cysteine rich glycoprotein

multiple interactions

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of SPARC mRNA]

NCBI chr11:55,284,985...55,310,906
Ensembl chr11:55,285,326...55,314,009

G

Spi-B transcription factor (Spi-1/PU.1 related)

increases expression

Curcumin results in increased expression of SPIB mRNA

NCBI chr 7:44,175,419...44,181,511
Ensembl chr 7:44,175,417...44,181,495

G

sparc/osteonectin, cwcv and kazal-like domains proteoglycan 1

increases expression

Curcumin results in increased expression of SPOCK1 mRNA

NCBI chr13:57,569,008...58,056,194
Ensembl chr13:57,569,008...58,056,146

G

secreted phosphoprotein 1

multiple interactions

Curcumin inhibits the reaction [Cadmium Chloride results in increased export of SPP1 protein]

NCBI chr 5:104,582,977...104,588,919
Ensembl chr 5:104,582,984...104,588,916

G

squalene epoxidase

decreases expression
affects expression

Curcumin results in decreased expression of SQLE mRNA
Curcumin affects the expression of SQLE mRNA

NCBI chr15:59,186,941...59,203,042
Ensembl chr15:59,186,926...59,203,041

G

sequestosome 1

decreases expression
increases expression
multiple interactions

Curcumin results in decreased expression of SQSTM1 protein
Curcumin results in increased expression of SQSTM1 protein
4-phenylbutyric acid inhibits the reaction [Curcumin results in decreased expression of SQSTM1 protein]; Curcumin inhibits the reaction [4,6-dimorpholino-N-(4-nitrophenyl)-1,3,5-triazin-2-amine results in increased phosphorylation of SQSTM1 protein]; Curcumin inhibits the reaction [Sirolimus results in decreased expression of SQSTM1 protein]; Curcumin inhibits the reaction [Tunicamycin results in decreased expression of SQSTM1 protein]; Curcumin promotes the reaction [sodium arsenite results in increased expression of SQSTM1 protein]; NFE2L2 protein affects the reaction [Curcumin promotes the reaction [sodium arsenite results in increased expression of SQSTM1 protein]]

PMID:34634291 PMID:34758851 PMID:36640941

NCBI chr11:50,090,979...50,105,303
Ensembl chr11:50,090,193...50,101,654

G

Rous sarcoma oncogene

decreases expression
multiple interactions
decreases activity

Curcumin results in decreased expression of SRC protein
[Curcumin binds to 4-bis(2-chloroethyl)aminobenzaldehyde] which results in decreased activity of SRC protein
[Curcumin binds to 4-bis(2-chloroethyl)aminobenzaldehyde] inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of SRC protein]
Curcumin analog results in decreased activity of SRC protein; Curcumin results in decreased activity of SRC protein

PMID:16959222 PMID:33617879

NCBI chr 2:157,265,828...157,313,758
Ensembl chr 2:157,260,364...157,313,782

G

sterol regulatory element binding transcription factor 1

affects expression
multiple interactions
decreases expression

Curcumin affects the expression of SREBF1 mRNA; Curcumin affects the expression of SREBF1 protein
Curcumin inhibits the reaction [bisphenol A results in increased expression of SREBF1 mRNA]; Curcumin inhibits the reaction [bisphenol A results in increased expression of SREBF1 protein]
Curcumin results in decreased expression of SREBF1 mRNA

PMID:27208389 PMID:37701206

NCBI chr11:60,089,910...60,113,407
Ensembl chr11:60,089,915...60,113,407

G

sterol regulatory element binding factor 2

affects expression
multiple interactions
decreases expression

Curcumin affects the expression of SREBF2 mRNA; Curcumin affects the expression of SREBF2 protein
Curcumin inhibits the reaction [bisphenol A results in increased expression of SREBF2 protein]
Curcumin results in decreased expression of SREBF2 mRNA

PMID:27208389 PMID:37701206

NCBI chr15:82,031,455...82,089,580
Ensembl chr15:82,031,382...82,089,580

G

spermidine synthase

multiple interactions

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of SRM mRNA]

NCBI chr 4:148,675,970...148,679,076
Ensembl chr 4:148,675,960...148,679,450

G

serine and arginine-rich splicing factor 1

increases expression

Curcumin results in increased expression of SRSF1 mRNA

NCBI chr11:87,937,325...87,944,583
Ensembl chr11:87,938,199...87,944,581

G

serine and arginine-rich splicing factor 2

increases expression

Curcumin results in increased expression of SRSF2 mRNA

NCBI chr11:116,740,723...116,744,511
Ensembl chr11:116,740,727...116,743,920

G

serine and arginine-rich splicing factor 3

increases expression

Curcumin results in increased expression of SRSF3 mRNA

NCBI chr17:29,251,634...29,262,346
Ensembl chr17:29,251,602...29,262,347

G

serine and arginine-rich splicing factor 5

decreases expression

Curcumin results in decreased expression of SRSF5 mRNA

NCBI chr12:80,992,308...80,997,277
Ensembl chr12:80,992,278...80,997,281

G

serine and arginine-rich splicing factor 6

increases expression

Curcumin results in increased expression of SRSF6 mRNA

NCBI chr 2:162,773,428...162,779,041
Ensembl chr 2:162,773,448...162,779,041

G

signal transducer and activator of transcription 1

multiple interactions

Curcumin inhibits the reaction [IFNG protein results in increased expression of and results in increased phosphorylation of STAT1 protein]
Curcumin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of STAT1 protein]

PMID:16959222 PMID:21811692

NCBI chr 1:52,158,588...52,201,024
Ensembl chr 1:52,158,599...52,201,024

G

signal transducer and activator of transcription 3

multiple interactions
decreases expression
increases phosphorylation
decreases phosphorylation

Arsenic Trioxide promotes the reaction [Curcumin results in decreased expression of STAT3 protein]; Bortezomib promotes the reaction [Curcumin results in decreased phosphorylation of STAT3 protein]; Curcumin inhibits the reaction [IFNG protein results in increased expression of and results in increased phosphorylation of STAT3 protein]; Curcumin inhibits the reaction [TNF protein results in increased phosphorylation of STAT3 protein]; Curcumin inhibits the reaction [Trichloroethylene results in increased phosphorylation of STAT3 protein]
[Curcumin binds to 4-bis(2-chloroethyl)aminobenzaldehyde] inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and affects the localization of STAT3 protein]
Curcumin analog inhibits the reaction [Copper Sulfate results in increased expression of STAT3 protein]; Curcumin inhibits the reaction [bisphenol A results in increased expression of STAT3 mRNA]; Curcumin inhibits the reaction [Copper Sulfate results in increased expression of STAT3 protein]
Curcumin results in decreased expression of STAT3 mRNA
Curcumin results in increased phosphorylation of STAT3 protein
Curcumin results in decreased expression of STAT3 mRNA; Curcumin results in decreased expression of STAT3 protein

PMID:16959222 PMID:17666914 PMID:19383353 PMID:20816778 PMID:25822711 More...

NCBI chr11:100,777,632...100,830,447
Ensembl chr11:100,775,924...100,830,366

G

signal transducer and activator of transcription 4

multiple interactions

Curcumin promotes the reaction [IFNB1 protein results in increased phosphorylation of STAT4 protein]

NCBI chr 1:52,026,265...52,146,348
Ensembl chr 1:52,026,307...52,146,348

G

signal transducer and activator of transcription 5A

increases cleavage
decreases expression

Curcumin results in increased cleavage of STAT5A protein
Curcumin results in decreased expression of STAT5A protein

NCBI chr11:100,750,177...100,775,995
Ensembl chr11:100,750,177...100,775,995

G

signal transducer and activator of transcription 5B

increases cleavage
decreases expression

Curcumin results in increased cleavage of STAT5B protein
Curcumin results in decreased expression of STAT5B protein

NCBI chr11:100,671,557...100,741,407
Ensembl chr11:100,671,557...100,741,550

G

steroid sulfatase

decreases expression

Curcumin results in decreased expression of STS mRNA

NCBI chr X:168,856,332...169,015,037
Ensembl chr X:168,909,030...169,014,924

G

syntaxin 3

multiple interactions

[Docosahexaenoic Acids co-treated with Curcumin] results in increased expression of STX3 mRNA

NCBI chr19:11,752,482...11,798,933
Ensembl chr19:11,752,482...11,796,767

G

sulfatase 1

increases expression

Curcumin results in increased expression of SULF1 mRNA; Curcumin results in increased expression of SULF1 protein

NCBI chr 1:12,762,421...12,946,090
Ensembl chr 1:12,762,501...12,931,416

G

sulfatase 2

multiple interactions

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of SULF2 mRNA]

NCBI chr 2:165,915,819...165,997,603
Ensembl chr 2:165,915,009...165,997,583

G

SUZ12 polycomb repressive complex 2 subunit

decreases expression

Curcumin results in decreased expression of SUZ12 mRNA

NCBI chr11:79,883,932...79,924,949
Ensembl chr11:79,883,932...79,924,949

G

synaptonemal complex protein 2

increases expression

Curcumin results in increased expression of SYCP2 mRNA

NCBI chr 2:177,987,088...178,051,580
Ensembl chr 2:177,987,086...178,049,478

G

synapsin II

multiple interactions

Curcumin inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of SYN2 protein]

NCBI chr 6:115,111,863...115,259,587
Ensembl chr 6:115,111,863...115,258,967

G

synaptic Ras GTPase activating protein 1 homolog (rat)

multiple interactions

Curcumin inhibits the reaction [sodium arsenite results in increased expression of SYNGAP1 protein]

NCBI chr17:27,160,186...27,191,408
Ensembl chr17:27,160,227...27,191,408

G

brachyury, T-box transcription factor T

decreases expression

Curcumin results in decreased expression of T mRNA

NCBI chr17:8,653,255...8,661,328
Ensembl chr17:8,653,255...8,661,328

G

transcriptional adaptor 3

affects expression

Curcumin affects the expression of TADA3 mRNA

NCBI chr 6:113,343,594...113,354,799
Ensembl chr 6:113,342,986...113,354,844

G

transaldolase 1

increases expression

Curcumin results in increased expression of TALDO1 mRNA

NCBI chr 7:140,972,073...140,982,889
Ensembl chr 7:140,972,112...140,982,881

G

TBC1 domain family, member 1

decreases expression

Curcumin results in decreased expression of TBC1D1 mRNA

NCBI chr 5:64,313,648...64,508,829
Ensembl chr 5:64,313,648...64,508,829

G

TBC1 domain family, member 8

increases expression

Curcumin results in increased expression of TBC1D8 mRNA

NCBI chr 1:39,410,576...39,517,860
Ensembl chr 1:39,410,573...39,517,836

G

TANK-binding kinase 1

multiple interactions

Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of TBK1 mRNA]

NCBI chr10:121,382,360...121,422,699
Ensembl chr10:121,382,360...121,422,692

G

transcription factor 7 like 2, T cell specific, HMG box

multiple interactions

Curcumin inhibits the reaction [CTNNB1 protein binds to TCF7L2 protein]; Curcumin results in decreased activity of [CTNNB1 protein binds to TCF7L2 protein]

NCBI chr19:55,730,227...55,922,091
Ensembl chr19:55,730,252...55,922,086

G

telomerase reverse transcriptase

decreases activity

Curcumin results in decreased activity of TERT protein

NCBI chr13:73,775,030...73,797,962
Ensembl chr13:73,775,030...73,797,962

G

tet methylcytosine dioxygenase 2

increases expression

curcumin increases expression of TET2 mRNA and protein in stomach

RGD

NCBI chr 3:133,169,438...133,250,882
Ensembl chr 3:133,169,440...133,250,900

G

transcription factor A, mitochondrial

multiple interactions

[Curcumin co-treated with Potassium Dichromate] results in increased expression of TFAM protein

NCBI chr10:71,061,298...71,074,157
Ensembl chr10:71,061,294...71,074,110

G

transcription factor EB

multiple interactions

[Curcumin co-treated with sodium arsenite] promotes the reaction TFEB protein; NFE2L2 protein affects the reaction [[Curcumin co-treated with sodium arsenite] promotes the reaction TFEB protein]

NCBI chr17:48,047,962...48,103,341
Ensembl chr17:48,047,955...48,103,344

G

transferrin receptor

increases expression
multiple interactions

Curcumin results in increased expression of TFRC mRNA
Curcumin inhibits the reaction [Carbon Tetrachloride results in decreased expression of TFRC protein]

PMID:17198877 PMID:18340409 PMID:24634837

NCBI chr16:32,427,714...32,451,612
Ensembl chr16:32,427,738...32,451,612

G

transforming growth factor, beta 1

multiple interactions
decreases expression
decreases activity

Curcumin inhibits the reaction [TGFB1 protein results in increased expression of RARA mRNA]
[1,2-Dimethylhydrazine co-treated with Curcumin] results in increased expression of TGFB1 mRNA; Curcumin affects the reaction [sodium arsenite results in increased expression of TGFB1 mRNA]; Curcumin analog inhibits the reaction [Streptozocin results in increased expression of TGFB1 mRNA]; Curcumin inhibits the reaction [Streptozocin results in increased expression of TGFB1 mRNA]
Curcumin results in decreased expression of TGFB1 mRNA; Curcumin results in decreased expression of TGFB1 protein
2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of TGFB1 protein]]; [Arsenic Trioxide co-treated with Curcumin] inhibits the reaction [Cisplatin results in increased expression of TGFB1 mRNA]; [Zinc binds to Curcumin] which affects the expression of TGFB1 mRNA; Curcumin analog inhibits the reaction [Glucose results in increased expression of TGFB1 mRNA]; Curcumin inhibits the reaction [AGT protein results in increased expression of TGFB1 protein]; Curcumin inhibits the reaction [Bleomycin results in increased expression of TGFB1 mRNA]; Curcumin inhibits the reaction [Bleomycin results in increased expression of TGFB1 protein]; Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 protein]; Curcumin inhibits the reaction [Cisplatin results in increased expression of TGFB1 mRNA]; Curcumin inhibits the reaction [Glucose results in increased expression of TGFB1 mRNA]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of TGFB1 protein]; Curcumin inhibits the reaction [TGFB1 protein results in decreased expression of PPARG mRNA]; Curcumin inhibits the reaction [Thioacetamide results in increased expression of TGFB1 protein]; pomegranate fruit rind promotes the reaction [Curcumin inhibits the reaction [Thioacetamide results in increased expression of TGFB1 protein]]
Curcumin results in decreased activity of TGFB1 protein

PMID:8940178 PMID:16751071 PMID:16959952 PMID:17434272 PMID:18006644 More...

NCBI chr 7:25,386,406...25,404,503
Ensembl chr 7:25,386,427...25,404,502

G

transforming growth factor, beta receptor I

multiple interactions
decreases expression

2-chloro-5-nitrobenzanilide inhibits the reaction [Curcumin results in decreased expression of TGFBR1 protein]; Buthionine Sulfoximine inhibits the reaction [Curcumin results in decreased expression of TGFBR1 mRNA]; Buthionine Sulfoximine inhibits the reaction [Curcumin results in decreased expression of TGFBR1 protein]
Curcumin results in decreased expression of TGFBR1 mRNA; Curcumin results in decreased expression of TGFBR1 protein

PMID:16959952 PMID:17531121 PMID:17602960

NCBI chr 4:47,353,258...47,414,926
Ensembl chr 4:47,353,222...47,414,931

G

transforming growth factor, beta receptor II

multiple interactions
decreases expression

Buthionine Sulfoximine inhibits the reaction [Curcumin results in decreased expression of TGFBR2 mRNA]; Buthionine Sulfoximine inhibits the reaction [Curcumin results in decreased expression of TGFBR2 protein]
Curcumin results in decreased expression of TGFBR2 mRNA; Curcumin results in decreased expression of TGFBR2 protein

PMID:16959952 PMID:17602960

NCBI chr 9:115,916,763...116,004,431
Ensembl chr 9:115,913,361...116,004,428

G

transglutaminase 2, C polypeptide

multiple interactions

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TGM2 mRNA]

NCBI chr 2:157,958,325...157,988,312
Ensembl chr 2:157,958,322...157,988,356

G

tyrosine hydroxylase

multiple interactions

[Curcumin co-treated with Chitosan analog] inhibits the reaction [Arsenic results in decreased expression of TH protein]; Curcumin inhibits the reaction [sodium arsenite results in decreased expression of TH protein]
Curcumin inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of TH protein]

PMID:19631675 PMID:22704994 PMID:27966075 PMID:30463061 PMID:31187328

NCBI chr 7:142,446,516...142,453,732
Ensembl chr 7:142,446,489...142,484,865

G

thrombospondin 1

multiple interactions

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of THBS1 mRNA]

NCBI chr 2:117,942,357...117,957,614
Ensembl chr 2:117,942,357...117,957,614

G

thymus cell antigen 1, theta

multiple interactions

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of THY1 mRNA]

NCBI chr 9:43,954,681...43,959,876
Ensembl chr 9:43,954,681...43,959,876

G

TIR domain containing adaptor molecule 1

multiple interactions

Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of TICAM1 mRNA]

NCBI chr17:56,576,462...56,583,767
Ensembl chr17:56,576,319...56,583,786

G

TIR domain containing adaptor molecule 2

multiple interactions

Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of TICAM2 mRNA]

NCBI chr18:46,691,298...46,707,600
Ensembl chr18:46,690,358...46,707,600

G

tissue inhibitor of metalloproteinase 1

multiple interactions
decreases expression

Curcumin inhibits the reaction [Thioacetamide results in increased expression of TIMP1 protein]; Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TIMP1 mRNA]
Curcumin inhibits the reaction [Cadmium Chloride results in increased export of TIMP1 protein]
Curcumin results in decreased expression of TIMP1 protein

PMID:17996675 PMID:18200517 PMID:27363783 PMID:29421648

NCBI chr X:20,736,524...20,740,972
Ensembl chr X:20,736,405...20,740,974

G

tissue inhibitor of metalloproteinase 2

multiple interactions
decreases expression

Curcumin inhibits the reaction [Indomethacin results in increased expression of TIMP2 protein]
Curcumin results in decreased expression of TIMP2 protein

PMID:16934674 PMID:17996675

NCBI chr11:118,191,887...118,246,237
Ensembl chr11:118,191,887...118,246,566

G

tight junction protein 1

multiple interactions

Curcumin inhibits the reaction [deoxynivalenol results in decreased expression of and affects the localization of TJP1 protein]; Curcumin inhibits the reaction [deoxynivalenol results in decreased expression of TJP1 mRNA]; Curcumin inhibits the reaction [Tobacco Smoke Pollution results in decreased expression of TJP1 mRNA]; Curcumin inhibits the reaction [Tobacco Smoke Pollution results in decreased expression of TJP1 protein]

PMID:26191140 PMID:35817260

NCBI chr 7:64,945,913...65,177,629
Ensembl chr 7:64,945,913...65,177,529

G

toll-like receptor 1

multiple interactions

Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of TLR1 mRNA]

NCBI chr 5:65,082,023...65,090,945
Ensembl chr 5:65,082,022...65,090,906

G

toll-like receptor 2

multiple interactions

Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of TLR2 mRNA]; Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of TLR2 protein]
Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of TLR2 mRNA]

PMID:22683883 PMID:23452621

NCBI chr 3:83,743,579...83,749,045
Ensembl chr 3:83,743,579...83,749,074

G

toll-like receptor 4

multiple interactions
decreases expression

[Dexamethasone co-treated with Curcumin] inhibits the reaction [[Ovalbumin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of TLR4 mRNA]; [Dexamethasone co-treated with Curcumin] inhibits the reaction [[Ovalbumin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of TLR4 protein]; Curcumin inhibits the reaction [[Lipopolysaccharides binds to TLR4 protein] which results in increased activity of IRF3 protein]; Curcumin inhibits the reaction [[Ovalbumin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of TLR4 mRNA]; Curcumin inhibits the reaction [[Ovalbumin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of TLR4 protein]; Curcumin inhibits the reaction [Lipopolysaccharides promotes the reaction [TLR4 protein binds to TLR4 protein]]
Curcumin inhibits the reaction [[boldenone undecylenate results in increased abundance of boldenone] which results in increased expression of TLR4 protein]; Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of TLR4 mRNA]; Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of TLR4 protein]; Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TLR4 protein]
Curcumin results in decreased expression of TLR4 mRNA; Curcumin results in decreased expression of TLR4 protein

PMID:16678799 PMID:17965732 PMID:19002562 PMID:22683883 PMID:34719837 More...

NCBI chr 4:66,745,788...66,765,338
Ensembl chr 4:66,745,821...66,848,521

G

thiol methyltransferase 1A1

multiple interactions

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of METTL7A mRNA]

NCBI chr15:100,201,969...100,227,882
Ensembl chr15:100,202,021...100,226,543

G

tenascin C

multiple interactions

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TNC mRNA]

NCBI chr 4:63,878,022...63,965,554
Ensembl chr 4:63,878,022...63,965,252

G

tumor necrosis factor

multiple interactions
decreases expression
affects expression
increases expression

[Curcumin inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]] which results in increased expression of HMOX1 protein; chromium mesoporphyrin inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]]; Curcumin inhibits the reaction [[benz(a)anthracene co-treated with TNF protein] results in increased expression of IL6 mRNA]; Curcumin inhibits the reaction [[TNF protein co-treated with IL1B protein] results in increased expression of CXCL8 mRNA]; Curcumin inhibits the reaction [[TNF protein co-treated with IL1B protein] results in increased expression of IL6 mRNA]; Curcumin inhibits the reaction [[TNF protein co-treated with IL1B protein] results in increased expression of PTGS2 protein]; Curcumin inhibits the reaction [[TNF protein co-treated with IL1B protein] results in increased phosphorylation of MAPK14 protein]; Curcumin inhibits the reaction [bisphenol A results in increased expression of TNF mRNA]; Curcumin inhibits the reaction [bisphenol A results in increased expression of TNF protein]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of TNF protein]; Curcumin inhibits the reaction [nickel chloride results in increased expression of TNF protein]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of TNF protein]; Curcumin inhibits the reaction [TNF protein affects the localization of RELA protein]; Curcumin inhibits the reaction [TNF protein promotes the reaction [Shiga Toxin binds to globotriaosylceramide]]; Curcumin inhibits the reaction [TNF protein results in decreased expression of CXCL8 mRNA]; Curcumin inhibits the reaction [TNF protein results in decreased expression of IL1B mRNA]; Curcumin inhibits the reaction [TNF protein results in decreased expression of IL6 mRNA]; Curcumin inhibits the reaction [TNF protein results in decreased expression of TNF mRNA]; Curcumin inhibits the reaction [TNF protein results in increased acetylation of RELA protein]; Curcumin inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]; Curcumin inhibits the reaction [TNF protein results in increased activity of CHUK protein]; Curcumin inhibits the reaction [TNF protein results in increased activity of IKBKB protein]; Curcumin inhibits the reaction [TNF protein results in increased activity of NFKB1 protein]; Curcumin inhibits the reaction [TNF protein results in increased activity of RELA protein]; Curcumin inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]; Curcumin inhibits the reaction [TNF protein results in increased expression of A4GALT mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of ADAM17 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of BCL2 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of BCL2 protein]; Curcumin inhibits the reaction [TNF protein results in increased expression of BCL2A1 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of BCL2L1 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of BCL2L1 protein]; Curcumin inhibits the reaction [TNF protein results in increased expression of BIRC2 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of BIRC2 protein]; Curcumin inhibits the reaction [TNF protein results in increased expression of BIRC3 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of CCL2 protein]; Curcumin inhibits the reaction [TNF protein results in increased expression of CCND1 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of CCND1 protein]; Curcumin inhibits the reaction [TNF protein results in increased expression of CFLAR mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of CXCL8 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of CXCL8 protein]; Curcumin inhibits the reaction [TNF protein results in increased expression of GSTP1 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; Curcumin inhibits the reaction [TNF protein results in increased expression of MMP9 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of MMP9 protein]; Curcumin inhibits the reaction [TNF protein results in increased expression of MYC mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of NOS2 protein]; Curcumin inhibits the reaction [TNF protein results in increased expression of PTGS2 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]; Curcumin inhibits the reaction [TNF protein results in increased expression of TNFRSF1A mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of TNFRSF1A protein]; Curcumin inhibits the reaction [TNF protein results in increased expression of TNFRSF1B mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of TNFRSF1B protein]; Curcumin inhibits the reaction [TNF protein results in increased expression of TRAF1 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of VEGFA mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of XIAP mRNA]; Curcumin inhibits the reaction [TNF protein results in increased localization of and results in increased activity of RELA protein]; Curcumin inhibits the reaction [TNF protein results in increased localization of RELA protein]; Curcumin inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased activity of AKT1 protein]; Curcumin inhibits the reaction [TNF protein results in increased phosphorylation of NFKBIA protein]; Curcumin inhibits the reaction [TNF protein results in increased phosphorylation of RELA protein]; Curcumin inhibits the reaction [TNF protein results in increased phosphorylation of STAT3 protein]; Dithiothreitol inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased activity of NFKB1 protein]]; Dithiothreitol inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased activity of RELA protein]]; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]]; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased activity of NFKB1 protein]]; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased activity of RELA protein]]; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased expression of BCL2 protein]]; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased expression of BCL2L1 protein]]; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased expression of BIRC2 protein]]; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased expression of CCND1 protein]]; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased expression of MMP9 protein]]; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased expression of NOS2 protein]]; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]]; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased activity of AKT1 protein]]; MIR125A mRNA inhibits the reaction [Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of TNF protein]]; SIRT6 protein promotes the reaction [Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of TNF protein]]
Curcumin results in decreased expression of TNF mRNA; Curcumin results in decreased expression of TNF protein
2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]]; [Sitagliptin Phosphate co-treated with Curcumin] inhibits the reaction [decamethrin results in increased expression of TNF protein]; [Zinc binds to Curcumin] inhibits the reaction [Ethanol results in increased expression of TNF mRNA]; CD40 protein affects the reaction [Curcumin affects the reaction [Lipopolysaccharides affects the expression of TNF protein]]; Curcumin affects the reaction [Lipopolysaccharides affects the expression of TNF protein]; Curcumin analog inhibits the reaction [Glucose results in increased expression of TNF mRNA]; Curcumin analog inhibits the reaction [Monocrotaline results in increased expression of TNF protein]; Curcumin inhibits the reaction [[boldenone undecylenate results in increased abundance of boldenone] which results in increased expression of TNF mRNA]; Curcumin inhibits the reaction [[Copper Sulfate results in increased abundance of Copper] which results in increased expression of TNF protein]; Curcumin inhibits the reaction [[Lipopolysaccharides co-treated with Tobacco Smoke Pollution] results in increased expression of TNF protein]; Curcumin inhibits the reaction [[TNF protein co-treated with IL1B protein] results in increased secretion of CXCL2 protein]; Curcumin inhibits the reaction [Acetaminophen results in increased expression of TNF mRNA]; Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF mRNA]; Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF protein]; Curcumin inhibits the reaction [Colistin results in increased expression of TNF protein]; Curcumin inhibits the reaction [Cyclophosphamide results in increased expression of TNF protein]; Curcumin inhibits the reaction [decamethrin results in increased expression of TNF protein]; Curcumin inhibits the reaction [Doxorubicin results in increased expression of TNF protein]; Curcumin inhibits the reaction [Ethanol results in increased expression of TNF mRNA]; Curcumin inhibits the reaction [Fructose results in increased expression of TNF protein]; Curcumin inhibits the reaction [Glucose results in increased expression of TNF mRNA]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of TNF protein]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Curcumin inhibits the reaction [sodium arsenite results in increased expression of TNF protein]; Curcumin inhibits the reaction [Streptozocin results in decreased expression of TNF protein]; Curcumin inhibits the reaction [Streptozocin results in increased expression of TNF protein]; Curcumin inhibits the reaction [Thioacetamide results in increased expression of TNF protein]; Curcumin inhibits the reaction [TNF protein results in increased expression of SELE protein]; Curcumin inhibits the reaction [TNF protein results in increased expression of SELP protein]; Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TNF mRNA]; Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TNF protein]; ICAM1 protein affects the reaction [Curcumin affects the reaction [Lipopolysaccharides affects the expression of TNF protein]]; pomegranate fruit rind promotes the reaction [Curcumin inhibits the reaction [Thioacetamide results in increased expression of TNF protein]]
Curcumin affects the expression of TNF mRNA; Curcumin affects the expression of TNF protein
Curcumin analog inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Curcumin analog inhibits the reaction [Streptozocin results in increased expression of TNF mRNA]; Curcumin inhibits the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of TNF mRNA]; Curcumin inhibits the reaction [Bleomycin results in increased expression of TNF mRNA]; Curcumin inhibits the reaction [Bleomycin results in increased expression of TNF protein]; Curcumin inhibits the reaction [butylbenzyl phthalate promotes the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of TNF mRNA]]; Curcumin inhibits the reaction [deoxynivalenol results in increased expression of TNF mRNA]; Curcumin inhibits the reaction [Dibutyl Phthalate results in increased expression of TNF protein]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; Curcumin inhibits the reaction [Paraquat results in increased expression of TNF protein]; Curcumin inhibits the reaction [sodium arsenite affects the expression of TNF mRNA]; Curcumin inhibits the reaction [TNF protein results in increased abundance of Dinoprostone]; Curcumin inhibits the reaction [TNF protein results in increased expression of IL1B mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of IL6 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of PTGS2 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased phosphorylation of RELA protein]; Curcumin inhibits the reaction [TNF protein results in increased secretion of Dinoprostone]; Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TNF mRNA]; NFE2L2 gene mutant form inhibits the reaction [Curcumin results in decreased expression of TNF mRNA]
Curcumin results in increased expression of TNF mRNA

PMID:14555224 PMID:15489888 PMID:16023083 PMID:16219905 PMID:16584726 More...

NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983

G

tumor necrosis factor receptor superfamily, member 10b

multiple interactions
increases expression

Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of TNFRSF10A mRNA]; TNFSF10 protein promotes the reaction [Curcumin results in increased expression of TNFRSF10A protein]

PMID:18226269 PMID:23452621

NCBI chr14:70,004,921...70,021,860
Ensembl chr14:70,004,921...70,021,860

G

tumor necrosis factor receptor superfamily, member 12a

multiple interactions

Curcumin inhibits the reaction [Doxorubicin results in increased expression of TNFRSF12A mRNA]

NCBI chr17:23,894,419...23,896,423
Ensembl chr17:23,894,419...23,896,442

G

tumor necrosis factor receptor superfamily, member 1a

multiple interactions

Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of TNFRSF1A mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of TNFRSF1A mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of TNFRSF1A protein]

PMID:17666914 PMID:23452621

NCBI chr 6:125,326,686...125,339,446
Ensembl chr 6:125,326,325...125,339,447

G

tumor necrosis factor receptor superfamily, member 1b

multiple interactions

Curcumin inhibits the reaction [TNF protein results in increased expression of TNFRSF1B mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of TNFRSF1B protein]

NCBI chr 4:144,938,938...144,973,453
Ensembl chr 4:144,940,033...144,973,440

G

tumor necrosis factor receptor superfamily, member 21

multiple interactions

[arsenic trioxide co-treated with Curcumin] results in increased expression of TNFRSF21 protein

NCBI chr17:43,327,446...43,400,079
Ensembl chr17:43,327,446...43,400,080

G

tumor necrosis factor (ligand) superfamily, member 10

multiple interactions
decreases expression

Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of TNFSF10 mRNA]; TNFSF10 protein promotes the reaction [Curcumin results in decreased activity of RELA protein]; TNFSF10 protein promotes the reaction [Curcumin results in decreased expression of BCL2 protein]; TNFSF10 protein promotes the reaction [Curcumin results in decreased expression of BCL2L1 protein]; TNFSF10 protein promotes the reaction [Curcumin results in decreased expression of CCND1 protein]; TNFSF10 protein promotes the reaction [Curcumin results in decreased expression of CXCL8 protein]; TNFSF10 protein promotes the reaction [Curcumin results in decreased expression of MMP2 protein]; TNFSF10 protein promotes the reaction [Curcumin results in decreased expression of MMP9 protein]; TNFSF10 protein promotes the reaction [Curcumin results in decreased expression of PLAU protein]; TNFSF10 protein promotes the reaction [Curcumin results in decreased expression of PTGS2 protein]; TNFSF10 protein promotes the reaction [Curcumin results in decreased expression of VEGFA protein]; TNFSF10 protein promotes the reaction [Curcumin results in increased expression of BAK1 protein]; TNFSF10 protein promotes the reaction [Curcumin results in increased expression of BAX protein]; TNFSF10 protein promotes the reaction [Curcumin results in increased expression of CDKN1A protein]; TNFSF10 protein promotes the reaction [Curcumin results in increased expression of CDKN1B protein]; TNFSF10 protein promotes the reaction [Curcumin results in increased expression of TNFRSF10A protein]; TNFSF10 protein promotes the reaction [Curcumin results in increased expression of TNFRSF10B protein]
Curcumin results in decreased expression of TNFSF10 mRNA

PMID:15713895 PMID:16101141 PMID:18226269 PMID:23452621

NCBI chr 3:27,371,226...27,393,814
Ensembl chr 3:27,371,177...27,396,576

G

tumor necrosis factor (ligand) superfamily, member 11

multiple interactions

Curcumin inhibits the reaction [TNFSF11 protein results in increased activity of CHUK protein]; Curcumin inhibits the reaction [TNFSF11 protein results in increased expression of PTGS2 protein]
Curcumin inhibits the reaction [IL1A protein results in increased expression of TNFSF11 protein]

PMID:15129424 PMID:18719352

NCBI chr14:78,514,886...78,545,483
Ensembl chr14:78,514,885...78,545,483

G

tumor necrosis factor (ligand) superfamily, member 12

multiple interactions

Curcumin inhibits the reaction [Doxorubicin results in increased expression of TNFSF12 protein]

NCBI chr11:69,577,066...69,586,924
Ensembl chr11:69,577,076...69,586,675

G

tumor necrosis factor (ligand) superfamily, member 14

multiple interactions

Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of TNFSF14 mRNA]

NCBI chr17:57,496,437...57,501,182
Ensembl chr17:57,496,492...57,501,177

G

tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase

decreases expression

Curcumin analog results in decreased expression of TNKS mRNA

NCBI chr 8:35,296,333...35,432,844
Ensembl chr 8:35,293,614...35,432,844

G

troponin I, cardiac 3

multiple interactions

Curcumin inhibits the reaction [Doxorubicin results in increased expression of TNNI3 protein]

NCBI chr 7:4,521,304...4,526,228
Ensembl chr 7:4,521,304...4,527,228

G

topoisomerase (DNA) II alpha

multiple interactions
decreases expression

[Curcumin co-treated with Azacitidine] results in decreased expression of TOP2A mRNA; [sulfinosine co-treated with Curcumin] results in decreased expression of TOP2A mRNA
Curcumin analog results in decreased expression of TOP2A mRNA; Curcumin results in decreased expression of TOP2A mRNA

PMID:18348204 PMID:18414057 PMID:26409325

NCBI chr11:98,883,773...98,915,037
Ensembl chr11:98,883,769...98,915,015

G

topoisomerase (DNA) II beta

multiple interactions
decreases expression

Curcumin inhibits the reaction [Arsenic results in decreased expression of TOP2B mRNA]; Curcumin inhibits the reaction [Arsenic results in decreased expression of TOP2B protein]
Curcumin analog results in decreased expression of TOP2B mRNA

PMID:21332098 PMID:26409325

NCBI chr14:6,038,976...6,104,585
Ensembl chr14:6,034,301...6,104,584

G

tryptophan hydroxylase 1

multiple interactions

[Curcumin co-treated with Chitosan analog] inhibits the reaction [Arsenic results in decreased expression of TPH1 protein]

NCBI chr 7:46,294,065...46,321,961
Ensembl chr 7:46,294,065...46,321,961

G

TNFRSF1A-associated via death domain

decreases expression

Curcumin results in decreased expression of TRADD mRNA

NCBI chr 8:105,985,207...105,991,226
Ensembl chr 8:105,984,918...105,991,241

G

TNF receptor-associated factor 1

multiple interactions
decreases expression

Curcumin inhibits the reaction [TNF protein results in increased expression of TRAF1 mRNA]
Curcumin results in decreased expression of TRAF1 protein

PMID:16023083 PMID:16219905 PMID:19372569

NCBI chr 2:34,831,762...34,851,784
Ensembl chr 2:34,831,762...34,851,784

G

TNF receptor-associated factor 2

increases expression

Curcumin results in increased expression of TRAF2 mRNA

NCBI chr 2:25,407,994...25,436,952
Ensembl chr 2:25,407,994...25,436,952

G

TNF receptor-associated factor 3

increases expression

Curcumin results in increased expression of TRAF3 mRNA

NCBI chr12:111,132,799...111,233,589
Ensembl chr12:111,132,804...111,233,587

G

TNF receptor-associated factor 6

increases expression
multiple interactions

Curcumin results in increased expression of TRAF6 mRNA
Curcumin inhibits the reaction [[boldenone undecylenate results in increased abundance of boldenone] which results in increased expression of TRAF6 mRNA]

PMID:16101141 PMID:34719837

NCBI chr 2:101,508,765...101,532,013
Ensembl chr 2:101,508,774...101,532,014

G

tRNA aspartic acid methyltransferase 1

increases expression

Curcumin results in increased expression of DNMT2

NCBI chr 2:13,509,690...13,549,475
Ensembl chr 2:13,513,825...13,549,479

G

triggering receptor expressed on myeloid cells 1

decreases expression

Curcumin results in decreased expression of TREM1 mRNA

NCBI chr17:48,539,763...48,553,955
Ensembl chr17:48,539,796...48,553,952

G

transferrin

increases expression

Curcumin results in increased expression of TF mRNA

NCBI chr 9:103,086,075...103,107,485
Ensembl chr 9:103,081,200...103,107,643

G

tribbles pseudokinase 3

increases expression

Curcumin results in increased expression of TRIB3 mRNA

NCBI chr 2:152,179,345...152,185,980
Ensembl chr 2:152,179,342...152,185,952

G

tripartite motif-containing 15

multiple interactions

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TRIM15 mRNA]

NCBI chr17:37,171,582...37,179,066
Ensembl chr17:37,171,583...37,178,102

G

tripartite motif-containing 16

increases expression

Curcumin results in increased expression of TRIM16 mRNA

NCBI chr11:62,711,034...62,733,774
Ensembl chr11:62,711,057...62,741,634

G

transformation related protein 53

multiple interactions
decreases expression
increases expression
increases phosphorylation
increases acetylation
affects expression
affects localization

[Arsenic Trioxide co-treated with Curcumin] results in increased expression of TP53 protein; [Curcumin co-treated with Arsenic Trioxide] results in increased expression of TP53 protein; [Curcumin co-treated with Metribolone] results in increased phosphorylation of TP53 protein; [piperine co-treated with Curcumin] results in decreased expression of TP53 protein; [Vitamin E co-treated with Curcumin] results in decreased expression of TP53 protein; Curcumin inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of and results in increased activity of TP53 protein]; Curcumin inhibits the reaction [bisphenol A results in decreased expression of TP53 protein]; Curcumin inhibits the reaction [bisphenol A results in increased expression of TP53 protein]; dorsomorphin inhibits the reaction [Curcumin results in increased phosphorylation of TP53 protein]; SB 203580 inhibits the reaction [Curcumin results in increased phosphorylation of TP53 protein]
Curcumin analog results in decreased expression of TP53 mRNA; Curcumin results in decreased expression of TP53 mRNA; Curcumin results in decreased expression of TP53 protein
Curcumin results in increased expression of TRP53 mRNA
[Curcumin co-treated with Quercetin] inhibits the reaction [Benzo(a)pyrene results in decreased acetylation of TRP53 protein]; [Curcumin co-treated with Quercetin] inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of TRP53 protein]; Curcumin affects the reaction [KRAS protein affects the localization of TRP53 protein]; Curcumin inhibits the reaction [Benzo(a)pyrene results in decreased acetylation of TRP53 protein]; Curcumin inhibits the reaction [deoxynivalenol results in increased expression of TRP53 protein]
[Curcumin results in increased expression of SERPINB5] which results in increased expression of TP53 protein; Curcumin results in increased expression of TP53; Curcumin results in increased expression of TP53 protein
[Curcumin binds to carboxymethyl-chitosan analog] inhibits the reaction [AGT protein modified form results in decreased degradation of TP53 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[Curcumin binds to carboxymethyl-chitosan analog] inhibits the reaction [AGT protein modified form results in decreased degradation of TP53 protein]]; carboxymethyl-chitosan analog promotes the reaction [Curcumin inhibits the reaction [AGT protein modified form results in increased acetylation of TP53 protein]]; Curcumin inhibits the reaction [[Copper Sulfate results in increased abundance of Copper] which results in increased expression of TP53 mRNA]; Curcumin inhibits the reaction [AGT protein modified form promotes the reaction [TP53 protein binds to EP300 protein]]; Curcumin inhibits the reaction [AGT protein modified form results in increased expression of and results in increased phosphorylation of and results in increased acetylation of TP53 protein]; Curcumin inhibits the reaction [Cyclophosphamide results in increased mutagenesis of TP53 exon]; Curcumin inhibits the reaction [Doxorubicin results in increased expression of TP53 protein]; Curcumin inhibits the reaction [TP53 protein binds to EP300 protein]; Curcumin results in decreased expression of and results in decreased acetylation of TP53 protein
Curcumin results in increased acetylation of TP53 protein
Curcumin affects the expression of TP53 protein; Curcumin analog affects the expression of TP53 mRNA; Curcumin analog affects the expression of TP53 protein
Curcumin affects the localization of TP53 protein

PMID:17041101 PMID:17332930 PMID:19020741 PMID:19227835 PMID:19944674 More...

NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699

G

transient receptor potential cation channel, subfamily V, member 6

multiple interactions

[Curcumin binds to and results in increased activity of VDR protein] which results in increased expression of TRPV6 mRNA

NCBI chr 6:41,597,553...41,613,339
Ensembl chr 6:41,597,558...41,613,339

G

TSC complex subunit 2

decreases phosphorylation

Curcumin results in decreased phosphorylation of TSC2 protein

NCBI chr17:24,814,788...24,851,607
Ensembl chr17:24,814,790...24,851,604

G

tubulin, beta 3 class III

multiple interactions
increases expression

Curcumin inhibits the reaction [bisphenol A results in decreased expression of TUBB3 mRNA]
Curcumin results in increased expression of TUBB3 mRNA

NCBI chr 8:124,138,292...124,148,754
Ensembl chr 8:124,138,163...124,148,754

G

thioredoxin interacting protein

multiple interactions

Curcumin inhibits the reaction [Aflatoxin B1 results in increased expression of TXNIP mRNA]

NCBI chr 3:96,465,273...96,469,173
Ensembl chr 3:96,465,273...96,469,199

G

thioredoxin reductase 1

increases expression
increases oxidation

Curcumin analog results in increased expression of TXNRD1 mRNA; Curcumin results in increased expression of TXNRD1 mRNA
Curcumin results in increased oxidation of TXNRD1 protein

PMID:17198877 PMID:18299980 PMID:21782934 PMID:26409325

NCBI chr10:82,669,785...82,733,558
Ensembl chr10:82,669,785...82,733,546

G

thymidine phosphorylase

decreases expression
multiple interactions

Curcumin results in decreased expression of TYMP mRNA; Curcumin results in decreased expression of TYMP protein
[Curcumin results in decreased expression of TYMP protein] which results in increased susceptibility to Cisplatin

NCBI chr15:89,255,834...89,261,282
Ensembl chr15:89,256,134...89,261,242

G

TYRO protein tyrosine kinase binding protein

multiple interactions

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TYROBP mRNA]

NCBI chr 7:30,113,207...30,117,007
Ensembl chr 7:30,113,185...30,117,010

G

ubiquitin-like modifier activating enzyme 7

affects expression
multiple interactions

Curcumin affects the expression of UBA7 mRNA; Curcumin affects the expression of UBA7 protein
Curcumin affects the reaction [Acetylcysteine results in increased expression of UBA7 protein]; Curcumin inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of UBA7 protein]

NCBI chr 9:107,852,766...107,861,255
Ensembl chr 9:107,852,704...107,861,259

G

ubiquitin C

increases expression

Curcumin results in increased expression of UBC mRNA

NCBI chr 5:125,463,029...125,467,081
Ensembl chr 5:125,463,029...125,467,266

G

ubiquitin-conjugating enzyme E2C

decreases expression

Curcumin results in decreased expression of UBE2C mRNA

NCBI chr 2:164,611,849...164,614,822
Ensembl chr 2:164,611,818...164,620,742

G

uncoupling protein 1 (mitochondrial, proton carrier)

affects expression

Curcumin affects the expression of UCP1 mRNA

NCBI chr 8:84,016,977...84,025,085
Ensembl chr 8:84,016,981...84,025,081

G

UDP glucuronosyltransferase 1 family, polypeptide A1

increases expression
multiple interactions
increases glucuronidation

Curcumin results in increased expression of UGT1A1 mRNA
Curcumin analog results in increased expression of UGT1A1 mRNA; Curcumin analog results in increased expression of UGT1A1 protein
Curcumin promotes the reaction [Aflatoxin B1 results in increased activity of UGT1A1 protein]
UGT1A1 protein results in increased glucuronidation of Curcumin

PMID:14557274 PMID:16819192 PMID:20015472 PMID:26991801 PMID:29228771

NCBI chr 1:88,139,681...88,147,724
Ensembl chr 1:88,139,681...88,146,719

G

UDP glycosyltransferase 1 family, polypeptide A10

increases glucuronidation

UGT1A10 protein results in increased glucuronidation of Curcumin

NCBI chr 1:87,983,133...88,147,724
Ensembl chr 1:87,983,110...88,146,726

G

UDP glucuronosyltransferase 1 family, polypeptide A6B

increases expression

Curcumin results in increased expression of UGT1A6 mRNA

NCBI chr 1:88,030,979...88,146,720
Ensembl chr 1:88,030,974...88,146,725

G

UDP glucuronosyltransferase 1 family, polypeptide A9

increases glucuronidation

UGT1A9 protein results in increased glucuronidation of Curcumin

NCBI chr 1:87,998,501...88,147,724
Ensembl chr 1:87,998,522...88,146,719

G

UDP glucuronosyltransferase 2 family, polypeptide B5

multiple interactions

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of UGT2B5 mRNA]

NCBI chr 5:87,272,805...87,288,199
Ensembl chr 5:87,272,819...87,288,177

G

UTP14A small subunit processome component

increases expression

Curcumin results in increased expression of UTP14A mRNA

NCBI chr X:47,345,811...47,371,326
Ensembl chr X:47,345,739...47,371,330

G

vasodilator-stimulated phosphoprotein

increases expression

Curcumin results in increased expression of VASP mRNA

NCBI chr 7:18,990,854...19,005,779
Ensembl chr 7:18,990,854...19,005,742

G

vascular cell adhesion molecule 1

affects expression
multiple interactions

Curcumin affects the expression of VCAM1 mRNA
Curcumin inhibits the reaction [Particulate Matter results in increased expression of VCAM1 protein]; Curcumin inhibits the reaction [titanium dioxide results in increased expression of VCAM1 protein]
Curcumin analog inhibits the reaction [Streptozocin results in increased expression of VCAM1 mRNA]
Curcumin analog inhibits the reaction [Copper Sulfate results in increased expression of VCAM1 protein]; Curcumin analog inhibits the reaction [Glucose results in increased expression of VCAM1 mRNA]; Curcumin inhibits the reaction [Copper Sulfate results in increased expression of VCAM1 protein]; Curcumin inhibits the reaction [Glucose results in increased expression of VCAM1 mRNA]

PMID:18752423 PMID:28700904 PMID:29244817 PMID:30431687

NCBI chr 3:115,903,669...115,923,337
Ensembl chr 3:115,903,598...115,923,337

G

versican

multiple interactions

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of VCAN mRNA]

NCBI chr13:89,803,429...89,891,146
Ensembl chr13:89,803,431...89,890,628

G

voltage-dependent anion channel 1

multiple interactions

Curcumin promotes the reaction [VDAC1 protein binds to VDAC1 protein]

NCBI chr11:52,251,905...52,280,224
Ensembl chr11:52,251,687...52,280,224

G

vitamin D (1,25-dihydroxyvitamin D3) receptor

multiple interactions

[Curcumin binds to and results in increased activity of VDR protein] which results in increased expression of CDKN1A mRNA; [Curcumin binds to and results in increased activity of VDR protein] which results in increased expression of CYP24A1 mRNA; [Curcumin binds to and results in increased activity of VDR protein] which results in increased expression of CYP3A4 mRNA; [Curcumin binds to and results in increased activity of VDR protein] which results in increased expression of TRPV6 mRNA; Curcumin binds to and results in increased activity of VDR protein; Curcumin inhibits the reaction [1,25-dihydroxy-26,27-dimethylcholecalciferol binds to VDR protein]; Curcumin promotes the reaction [VDR protein binds to NCOA1 protein]; Curcumin promotes the reaction [VDR protein binds to RXRA protein]

NCBI chr15:97,752,308...97,806,177
Ensembl chr15:97,752,306...97,808,511

G

vascular endothelial growth factor A

affects expression
decreases expression
multiple interactions

Curcumin affects the expression of VEGFA mRNA
Curcumin results in decreased expression of VEGFA mRNA; Curcumin results in decreased expression of VEGFA protein
Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of VEGFA mRNA]; Curcumin inhibits the reaction [Streptozocin results in increased expression of VEGFA mRNA]; Curcumin inhibits the reaction [Streptozocin results in increased expression of VEGFA protein]
[Curcumin co-treated with Gemcitabine] results in decreased expression of VEGFA protein; Curcumin inhibits the reaction [Dietary Fats results in increased expression of VEGFA mRNA]
[bisdemethoxycurcumin co-treated with Curcumin co-treated with demethoxycurcumin] inhibits the reaction [VEGF protein results in increased phosphorylation of AKT1 protein]; [bisdemethoxycurcumin co-treated with Curcumin co-treated with demethoxycurcumin] inhibits the reaction [VEGF protein results in increased phosphorylation of KDR protein]; [bisdemethoxycurcumin co-treated with Curcumin co-treated with demethoxycurcumin] inhibits the reaction [VEGF protein results in increased phosphorylation of MAPK1 protein]; [bisdemethoxycurcumin co-treated with Curcumin co-treated with demethoxycurcumin] inhibits the reaction [VEGF protein results in increased phosphorylation of MAPK3 protein]; [Curcumin analog co-treated with Sirolimus] inhibits the reaction [Oxygen deficiency results in increased expression of VEGFA protein]; [Curcumin analog co-treated with terpestacin] inhibits the reaction [Oxygen deficiency results in increased expression of VEGFA protein]; [Curcumin analog co-treated with Vorinostat] inhibits the reaction [Oxygen deficiency results in increased expression of VEGFA protein]; [Curcumin co-treated with Bortezomib] results in decreased expression of VEGFA protein; Curcumin analog inhibits the reaction [Oxygen deficiency results in increased expression of VEGFA protein]; Curcumin inhibits the reaction [IL18 protein results in increased expression of VEGFA mRNA]; Curcumin inhibits the reaction [IL18 protein results in increased expression of VEGFA protein]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of and results in increased secretion of VEGFA protein]; Curcumin inhibits the reaction [Paclitaxel results in increased expression of VEGFA protein]; Curcumin inhibits the reaction [TNF protein results in increased expression of VEGFA mRNA]; Curcumin inhibits the reaction [VEGF protein results in increased phosphorylation of KDR protein]; Curcumin inhibits the reaction [VEGF protein results in increased phosphorylation of MAPK1 protein]; Curcumin inhibits the reaction [VEGF protein results in increased phosphorylation of MAPK3 protein]; Curcumin inhibits the reaction [VEGFA protein results in increased expression of and results in increased activity of MMP2 protein]; Curcumin inhibits the reaction [VEGFA protein results in increased expression of PTGS2 mRNA]; Curcumin inhibits the reaction [VEGFA protein results in increased expression of PTGS2 protein]; Curcumin results in decreased expression of and results in decreased secretion of VEGFA protein; TNFSF10 protein promotes the reaction [Curcumin results in decreased expression of VEGFA protein]

PMID:16219905 PMID:16243823 PMID:16368150 PMID:17440100 PMID:17662242 More...

NCBI chr17:46,327,919...46,343,303
Ensembl chr17:46,327,919...46,343,295

G

von Hippel-Lindau tumor suppressor

multiple interactions

VHL protein promotes the reaction [Curcumin results in decreased expression of HIF1A protein]

NCBI chr 6:113,600,955...113,608,595
Ensembl chr 6:113,600,920...113,608,594

G

vimentin

multiple interactions

Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of VIM protein]
Curcumin inhibits the reaction [Tobacco Smoke Pollution results in increased expression of VIM mRNA]; Curcumin inhibits the reaction [Tobacco Smoke Pollution results in increased expression of VIM protein]

PMID:25656647 PMID:26191140

NCBI chr 2:13,579,122...13,587,637
Ensembl chr 2:13,578,738...13,587,637

G

vasoactive intestinal polypeptide

multiple interactions

Curcumin inhibits the reaction [VIP protein results in increased activity of MMP2 protein]; Curcumin inhibits the reaction [VIP protein results in increased activity of MMP9 protein]; Curcumin inhibits the reaction [VIP protein results in increased expression of CCND1 protein]
Curcumin inhibits the reaction [VIP protein results in increased expression of PTGS2 protein]

PMID:17434257 PMID:19189304

NCBI chr10:5,589,131...5,597,617
Ensembl chr10:5,589,218...5,597,617

G

Von Willebrand factor

multiple interactions

Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of VWF mRNA]; Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of VWF protein]

NCBI chr 6:125,529,911...125,663,642
Ensembl chr 6:125,523,737...125,663,642

G

WASP like actin nucleation promoting factor

increases expression

Curcumin results in increased expression of WASL mRNA

NCBI chr 6:24,613,809...24,665,185
Ensembl chr 6:24,613,804...24,665,008

G

Wnt inhibitory factor 1

multiple interactions
decreases expression

Curcumin inhibits the reaction [bisphenol A results in increased expression of WIF1 protein]
Curcumin results in decreased expression of WIF1 protein

NCBI chr10:120,869,909...120,936,547
Ensembl chr10:120,869,865...120,936,555

G

wingless-type MMTV integration site family, member 1

increases expression
multiple interactions

Curcumin results in increased expression of WNT1 mRNA
Curcumin inhibits the reaction [bisphenol A results in decreased expression of WNT1 mRNA]

NCBI chr15:98,687,738...98,691,711
Ensembl chr15:98,687,738...98,691,718

G

wingless-type MMTV integration site family, member 3

multiple interactions
increases expression

Curcumin inhibits the reaction [bisphenol A results in decreased expression of WNT3 mRNA]; Curcumin inhibits the reaction [bisphenol A results in decreased expression of WNT3 protein]
Curcumin results in increased expression of WNT3 mRNA; Curcumin results in increased expression of WNT3 protein

NCBI chr11:103,665,000...103,708,854
Ensembl chr11:103,664,976...103,708,783

G

WT1 transcription factor

decreases expression

Curcumin results in decreased expression of WT1 mRNA; Curcumin results in decreased expression of WT1 protein

PMID:18034345 PMID:19196508

NCBI chr 2:104,956,874...105,003,959
Ensembl chr 2:104,956,874...105,003,961

G

WW domain containing transcription regulator 1

decreases stability
multiple interactions

Curcumin results in decreased stability of WWTR1 protein
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Curcumin results in decreased expression of WWTR1 protein]; Curcumin results in decreased expression of and affects the localization of WWTR1 protein; Curcumin results in increased phosphorylation of and results in decreased stability of WWTR1 protein; WWTR1 protein inhibits the reaction [Curcumin results in decreased expression of EPCAM mRNA]; WWTR1 protein inhibits the reaction [Curcumin results in decreased expression of EPCAM protein]; WWTR1 protein inhibits the reaction [Curcumin results in decreased expression of POU5F1 mRNA]; WWTR1 protein inhibits the reaction [Curcumin results in decreased expression of POU5F1 protein]; WWTR1 protein inhibits the reaction [Curcumin results in decreased expression of PROM1 mRNA]; WWTR1 protein inhibits the reaction [Curcumin results in decreased expression of PROM1 protein]; WWTR1 protein inhibits the reaction [Curcumin results in increased susceptibility to Cisplatin]

NCBI chr 3:57,363,065...57,483,331
Ensembl chr 3:57,363,070...57,483,331

G

XIAP associated factor 1

increases expression

Curcumin results in increased expression of XAF1 mRNA; Curcumin results in increased expression of XAF1 protein

NCBI chr11:72,192,229...72,204,560
Ensembl chr11:72,192,455...72,204,559

G

X-box binding protein 1

increases expression

Curcumin results in increased expression of XBP1 mRNA

NCBI chr11:5,470,641...5,475,993
Ensembl chr11:5,470,659...5,475,893

G

xanthine dehydrogenase

multiple interactions

Curcumin inhibits the reaction [Indomethacin results in increased activity of XDH protein]

NCBI chr17:74,190,890...74,257,191
Ensembl chr17:74,190,890...74,257,191

G

X-linked inhibitor of apoptosis

multiple interactions
decreases expression

[arsenic trioxide co-treated with Curcumin] results in decreased expression of XIAP protein; [Curcumin co-treated with Doxorubicin] affects the expression of XIAP mRNA; arsenic trioxide promotes the reaction [Curcumin results in decreased expression of XIAP protein]; Curcumin inhibits the reaction [Nicotine results in increased expression of XIAP protein]; Curcumin inhibits the reaction [Paclitaxel results in increased expression of XIAP protein]; Curcumin inhibits the reaction [TNF protein results in increased expression of XIAP mRNA]; Curcumin promotes the reaction [lonidamine results in decreased expression of XIAP protein]; lonidamine promotes the reaction [Curcumin results in decreased expression of XIAP protein]
Curcumin analog results in decreased expression of XIAP mRNA; Curcumin results in decreased expression of XIAP mRNA; Curcumin results in decreased expression of XIAP protein

PMID:15911101 PMID:16023083 PMID:16173963 PMID:16219905 PMID:16243823 More...

NCBI chr X:41,148,483...41,198,541
Ensembl chr X:41,148,556...41,198,533

G

exportin 1

multiple interactions

Curcumin inhibits the reaction [KRAS protein results in decreased expression of XPO1 protein]

NCBI chr11:23,205,768...23,248,250
Ensembl chr11:23,206,055...23,248,249

G

X-ray repair complementing defective repair in Chinese hamster cells 1

multiple interactions

Curcumin inhibits the reaction [Arsenic results in decreased expression of XRCC1 mRNA]; Curcumin inhibits the reaction [Arsenic results in decreased expression of XRCC1 protein]

NCBI chr 7:24,246,124...24,272,863
Ensembl chr 7:24,245,714...24,272,865

G

X-ray repair complementing defective repair in Chinese hamster cells 4

multiple interactions

Curcumin inhibits the reaction [Arsenic results in decreased expression of XRCC4 mRNA]; Curcumin inhibits the reaction [Arsenic results in decreased expression of XRCC4 protein]

NCBI chr13:89,997,033...90,237,727
Ensembl chr13:89,922,146...90,237,727

G

X-ray repair complementing defective repair in Chinese hamster cells 5

decreases expression

Curcumin results in decreased expression of XRCC5 mRNA

NCBI chr 1:72,346,576...72,434,112
Ensembl chr 1:72,346,586...72,434,111

G

X-ray repair complementing defective repair in Chinese hamster cells 6

decreases expression

Curcumin results in decreased expression of XRCC6 mRNA

NCBI chr15:81,868,805...81,924,286
Ensembl chr15:81,872,036...81,924,286

G

yippee like 3

decreases expression

Curcumin results in decreased expression of YPEL3 mRNA

NCBI chr 7:126,376,135...126,379,682
Ensembl chr 7:126,376,127...126,379,686

G

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide

decreases expression

Curcumin results in decreased expression of YWHAE mRNA; Curcumin results in decreased expression of YWHAE protein

NCBI chr11:75,620,121...75,656,667
Ensembl chr11:75,623,695...75,656,671

G

zinc finger homeobox 3

decreases expression

Curcumin results in decreased expression of ZFHX3 mRNA

NCBI chr 8:109,005,975...109,688,272
Ensembl chr 8:108,669,276...109,688,262

G

zinc finger protein 287

increases expression

Curcumin results in increased expression of ZNF287 mRNA

NCBI chr11:62,583,270...62,622,749
Ensembl chr11:62,591,182...62,622,731

G

zinc finger protein 36, C3H type-like 1

decreases expression

Curcumin results in decreased expression of ZFP36L1 mRNA

NCBI chr12:80,154,534...80,159,787
Ensembl chr12:80,154,528...80,159,787

Diferuloylputrescine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily G member 2 (Junior blood group)

multiple interactions

[3-(6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino(1',2'-1,6)pyrido(3,4-b)indol-3-yl)propionic acid tert-butyl ester results in decreased activity of ABCG2 protein] which results in decreased secretion of diferuloylputrescine metabolite

NCBI chr 6:58,561,476...58,669,436
Ensembl chr 6:58,561,508...58,672,661

G

nitric oxide synthase 2, inducible

multiple interactions

[diferuloylputrescine results in decreased expression of NOS2 protein] which results in decreased chemical synthesis of Nitric Oxide; diferuloylputrescine inhibits the reaction [Lipopolysaccharides results in increased activity of NOS2 protein]; diferuloylputrescine inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; diferuloylputrescine inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]

NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080

ethyl trans-caffeate

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

thymoma viral proto-oncogene 1

multiple interactions

ethyl caffeate affects the phosphorylation of and affects the activity of AKT1 protein

NCBI chr12:112,620,260...112,641,266
Ensembl chr12:112,620,255...112,641,318

G

cadherin 2

affects expression

ethyl caffeate affects the expression of CDH2 protein

NCBI chr18:16,721,934...16,942,303
Ensembl chr18:16,721,934...16,942,303

G

cyclin dependent kinase 2

affects expression

ethyl caffeate affects the expression of CDK2 protein

NCBI chr10:128,533,807...128,540,920
Ensembl chr10:128,533,808...128,540,900

G

cyclin dependent kinase 4

affects expression

ethyl caffeate affects the expression of CDK4 protein

NCBI chr10:126,899,404...126,903,157
Ensembl chr10:126,899,403...126,903,789

G

erb-b2 receptor tyrosine kinase 2

affects expression
multiple interactions

ethyl caffeate affects the expression of ERBB2 protein
ethyl caffeate affects the phosphorylation of and affects the activity of ERBB2 protein

NCBI chr11:98,303,310...98,328,542
Ensembl chr11:98,303,296...98,328,542

G

fibroblast growth factor receptor 1

affects expression

ethyl caffeate affects the expression of FGFR1 protein

NCBI chr 8:26,008,808...26,067,819
Ensembl chr 8:26,003,670...26,065,734

G

integrin linked kinase

affects expression

ethyl caffeate affects the expression of ILK protein

NCBI chr 7:105,385,797...105,392,132
Ensembl chr 7:105,385,799...105,392,132

G

integrin alpha 3

multiple interactions

ethyl caffeate affects the expression of [ITGA3 protein binds to ITGB1 protein]

NCBI chr11:94,935,301...94,967,637
Ensembl chr11:94,935,300...94,967,627

G

integrin beta 1 (fibronectin receptor beta)

multiple interactions

ethyl caffeate affects the expression of [ITGA3 protein binds to ITGB1 protein]

NCBI chr 8:129,412,135...129,460,060
Ensembl chr 8:129,412,135...129,459,681

G

kinase insert domain protein receptor

affects expression

ethyl caffeate affects the expression of KDR protein

NCBI chr 5:76,093,487...76,139,880
Ensembl chr 5:76,093,487...76,139,118

G

mitogen-activated protein kinase 1

multiple interactions

ethyl caffeate affects the phosphorylation of and affects the activity of MAPK1 protein

NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317

G

mitogen-activated protein kinase 3

multiple interactions

ethyl caffeate affects the phosphorylation of and affects the activity of MAPK3 protein

NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991

G

RB transcriptional corepressor 1

affects phosphorylation

ethyl caffeate affects the phosphorylation of RB1 protein

NCBI chr14:73,430,298...73,563,446
Ensembl chr14:73,421,113...73,563,262

ferulic acid

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

acetylcholinesterase

multiple interactions

ferulic acid inhibits the reaction [lead acetate results in increased activity of ACHE protein]

NCBI chr 5:137,286,516...137,292,728
Ensembl chr 5:137,285,781...137,292,728

G

actin alpha 2, smooth muscle, aorta

multiple interactions

ferulic acid inhibits the reaction [Silicon Dioxide results in increased expression of ACTA2 protein]

NCBI chr19:34,217,736...34,232,985
Ensembl chr19:34,218,490...34,232,990

G

thymoma viral proto-oncogene 1

multiple interactions

ferulic acid inhibits the reaction [Lipopolysaccharides results in decreased phosphorylation of AKT1 protein]; MIR17 mRNA affects the reaction [ferulic acid inhibits the reaction [Lipopolysaccharides results in decreased phosphorylation of AKT1 protein]]; PTEN protein inhibits the reaction [ferulic acid inhibits the reaction [Lipopolysaccharides results in decreased phosphorylation of AKT1 protein]]

NCBI chr12:112,620,260...112,641,266
Ensembl chr12:112,620,255...112,641,318

G

aminolevulinate, delta-, dehydratase

multiple interactions

ferulic acid inhibits the reaction [lead acetate results in decreased activity of ALAD protein]

NCBI chr 4:62,422,762...62,438,300
Ensembl chr 4:62,427,406...62,438,155

G

albumin

multiple interactions

ferulic acid inhibits the reaction [Silicon Dioxide results in increased expression of ALB protein]; ferulic acid inhibits the reaction [tyloxapol results in decreased expression of ALB mRNA]

PMID:33428986 PMID:37076581

NCBI chr 5:90,608,729...90,624,461
Ensembl chr 5:90,608,756...90,624,461

G

apolipoprotein B

decreases expression

ferulic acid results in decreased expression of APOB protein

NCBI chr12:8,027,629...8,066,839
Ensembl chr12:8,027,648...8,066,835

G

beta-site APP cleaving enzyme 1

multiple interactions

ferulic acid inhibits the reaction [Copper results in increased expression of BACE1 mRNA]

NCBI chr 9:45,749,878...45,775,694
Ensembl chr 9:45,749,878...45,775,697

G

BCL2-associated X protein

multiple interactions

ferulic acid inhibits the reaction [Lipopolysaccharides results in increased expression of BAX protein]; ferulic acid inhibits the reaction [Streptozocin results in increased expression of BAX protein]; MIR17 mRNA affects the reaction [ferulic acid inhibits the reaction [Lipopolysaccharides results in increased expression of BAX protein]]; PTEN protein inhibits the reaction [ferulic acid inhibits the reaction [Lipopolysaccharides results in increased expression of BAX protein]]

PMID:31029786 PMID:35110471

NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322

G

butyrylcholinesterase

multiple interactions

ferulic acid promotes the reaction [lead acetate results in increased activity of BCHE protein]

NCBI chr 3:73,543,138...73,615,767
Ensembl chr 3:73,543,141...73,615,748

G

B cell leukemia/lymphoma 2

multiple interactions

ferulic acid inhibits the reaction [Lipopolysaccharides results in decreased expression of BCL2 protein]; MIR17 mRNA affects the reaction [ferulic acid inhibits the reaction [Lipopolysaccharides results in decreased expression of BCL2 protein]]; PTEN protein inhibits the reaction [ferulic acid inhibits the reaction [Lipopolysaccharides results in decreased expression of BCL2 protein]]

NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004

G

complement component 3

multiple interactions

ferulic acid inhibits the reaction [Lipopolysaccharides results in increased expression of C3 protein]

NCBI chr17:57,510,967...57,535,136
Ensembl chr17:57,510,970...57,535,136

G

caspase 3

multiple interactions

ferulic acid analog inhibits the reaction [Streptozocin results in increased activity of CASP3 protein]; ferulic acid inhibits the reaction [Lipopolysaccharides results in increased cleavage of CASP3 protein]; MIR17 mRNA affects the reaction [ferulic acid inhibits the reaction [Lipopolysaccharides results in increased cleavage of CASP3 protein]]; PTEN protein inhibits the reaction [ferulic acid inhibits the reaction [Lipopolysaccharides results in increased cleavage of CASP3 protein]]

PMID:31029786 PMID:35110471

NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724

G

catalase

increases activity
multiple interactions

ferulic acid results in increased activity of CAT protein
ferulic acid inhibits the reaction [sodium arsenite results in decreased activity of CAT protein]
ferulic acid inhibits the reaction [[Fatty Acids, Unsaturated co-treated with Ethanol] results in decreased activity of CAT protein]; ferulic acid inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in decreased activity of CAT protein]; ferulic acid inhibits the reaction [Ethanol results in decreased activity of CAT protein]; ferulic acid inhibits the reaction [Fatty Acids, Unsaturated results in decreased activity of CAT protein]; ferulic acid inhibits the reaction [Thioacetamide results in decreased activity of CAT protein]

PMID:15381826 PMID:20573577 PMID:31584213 PMID:32278740 PMID:37393015

NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505

G

C-C motif chemokine ligand 2

multiple interactions

ferulic acid inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 protein]

NCBI chr11:81,926,403...81,928,278
Ensembl chr11:81,926,397...81,928,279

G

cellular communication network factor 2

multiple interactions

ferulic acid inhibits the reaction [Silicon Dioxide results in increased expression of CTGF protein]

NCBI chr10:24,471,340...24,474,581
Ensembl chr10:24,471,340...24,474,581

G

cyclin D1

decreases expression

ferulic acid results in decreased expression of CCND1 protein

PMID:15363954 PMID:15486966

NCBI chr 7:144,483,668...144,493,568
Ensembl chr 7:144,483,668...144,493,662

G

cadherin 1

multiple interactions

ferulic acid inhibits the reaction [Silicon Dioxide results in decreased expression of CDH1 protein]

NCBI chr 8:107,329,982...107,396,879
Ensembl chr 8:107,329,983...107,396,878

G

cyclin dependent kinase inhibitor 1A

increases expression

ferulic acid results in increased expression of CDKN1A protein

PMID:15363954 PMID:15486966

NCBI chr17:29,309,953...29,319,696
Ensembl chr17:29,309,950...29,319,701

G

collagen, type I, alpha 2

multiple interactions

ferulic acid inhibits the reaction [Silicon Dioxide results in increased expression of COL1A2 protein]

NCBI chr 6:4,505,618...4,541,543
Ensembl chr 6:4,504,814...4,541,544

G

cathepsin D

multiple interactions

[ferulic acid co-treated with Ascorbic Acid] inhibits the reaction [Isoproterenol results in increased activity of CTSD protein]

NCBI chr 7:141,929,647...141,941,564
Ensembl chr 7:141,929,648...141,941,775

G

C-X-C motif chemokine ligand 15

multiple interactions

[Ascorbic Acid co-treated with alpha-Tocopherol co-treated with ferulic acid] inhibits the reaction [[Ozone co-treated with Oxygen] results in increased expression of CXCL8 mRNA]

NCBI chr 5:90,942,393...90,950,926
Ensembl chr 5:90,942,393...90,950,926

G

cytochrome P450, family 1, subfamily a, polypeptide 1

decreases activity

ferulic acid results in decreased activity of CYP1A1 protein

NCBI chr 9:57,595,211...57,611,107
Ensembl chr 9:57,595,211...57,611,107

G

cytochrome P450, family 1, subfamily a, polypeptide 2

decreases activity

ferulic acid results in decreased activity of CYP1A2 protein

NCBI chr 9:57,584,220...57,590,938
Ensembl chr 9:57,584,220...57,590,986

G

desmin

multiple interactions

ferulic acid inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of DES protein]

NCBI chr 1:75,336,936...75,345,223
Ensembl chr 1:75,336,973...75,345,223

G

dihydrofolate reductase

decreases activity

ferulic acid results in decreased activity of DHFR protein

NCBI chr13:92,491,291...92,525,561
Ensembl chr13:92,491,234...92,525,561

G

dynamin 1-like

multiple interactions

ferulic acid inhibits the reaction [Streptozocin results in increased expression of DNM1L protein]

NCBI chr16:16,130,092...16,176,863
Ensembl chr16:16,130,094...16,176,823

G

fatty acid synthase

decreases expression

ferulic acid results in decreased expression of FASN mRNA

NCBI chr11:120,696,784...120,715,992
Ensembl chr11:120,696,672...120,715,373

G

ferredoxin 1

multiple interactions

ferulic acid analog promotes the reaction [Colforsin results in increased expression of FDX1 mRNA]

NCBI chr 9:51,854,323...51,874,902
Ensembl chr 9:51,854,606...51,874,856

G

glucose-6-phosphate dehydrogenase X-linked

decreases activity

ferulic acid results in decreased activity of G6PD protein

NCBI chr X:73,453,089...73,472,486
Ensembl chr X:73,453,089...73,472,800

G

galanin and GMAP prepropeptide

multiple interactions

[ferulic acid co-treated with Ascorbic Acid] inhibits the reaction [Isoproterenol results in increased activity of GAL protein]

NCBI chr19:3,459,915...3,464,544
Ensembl chr19:3,459,915...3,464,544

G

glutamic pyruvic transaminase, soluble

multiple interactions

ferulic acid inhibits the reaction [sodium arsenite results in increased activity of GPT protein]

NCBI chr15:76,580,926...76,583,875
Ensembl chr15:76,579,916...76,583,886

G

glutathione reductase

increases activity
multiple interactions

ferulic acid results in increased activity of GSR protein
ferulic acid inhibits the reaction [lead acetate results in increased activity of GSR protein]

PMID:20573577 PMID:25322819

NCBI chr 8:34,143,266...34,188,190
Ensembl chr 8:34,142,551...34,188,191

G

glucuronidase, beta

multiple interactions

[ferulic acid co-treated with Ascorbic Acid] inhibits the reaction [Isoproterenol results in increased activity of GUSB protein]

NCBI chr 5:130,011,278...130,031,890
Ensembl chr 5:130,017,852...130,031,890

G

holocarboxylase synthetase (biotin- [propriony-Coenzyme A-carboxylase (ATP-hydrolysing)] ligase)

decreases activity

ferulic acid results in decreased activity of HLCS protein

NCBI chr16:93,930,054...94,116,098
Ensembl chr16:93,929,741...94,114,430

G

3-hydroxy-3-methylglutaryl-Coenzyme A reductase

decreases expression

ferulic acid results in decreased expression of HMGCR mRNA

NCBI chr13:96,785,470...96,807,444
Ensembl chr13:96,785,475...96,807,444

G

interleukin 11

multiple interactions

ferulic acid inhibits the reaction [Imiquimod results in decreased expression of IL11 mRNA]

NCBI chr 7:4,775,372...4,785,877
Ensembl chr 7:4,775,372...4,785,858

G

interleukin 11 receptor subunit alpha 1

multiple interactions

ferulic acid inhibits the reaction [Imiquimod results in decreased expression of IL11RA1 mRNA]

NCBI chr 4:41,760,443...41,769,473
Ensembl chr 4:41,699,989...41,769,474

G

interleukin 11 receptor subunit alpha 2

multiple interactions

ferulic acid inhibits the reaction [Imiquimod results in decreased expression of IL11RA2 mRNA]

NCBI chr 4:42,656,001...42,665,744
Ensembl chr 4:42,656,001...42,665,763

G

interleukin 12b

multiple interactions

ferulic acid inhibits the reaction [Imiquimod results in increased expression of IL12B mRNA]

NCBI chr11:44,290,890...44,305,504
Ensembl chr11:44,290,890...44,304,860

G

interleukin 13 receptor, alpha 1

multiple interactions

ferulic acid inhibits the reaction [Imiquimod results in increased expression of IL13RA1 mRNA]

NCBI chr X:35,375,761...35,434,915
Ensembl chr X:35,375,763...35,434,912

G

interleukin 17A

multiple interactions

ferulic acid inhibits the reaction [Imiquimod results in increased expression of IL17A mRNA]; ferulic acid inhibits the reaction [Imiquimod results in increased expression of IL17A protein]

NCBI chr 1:20,801,129...20,804,720
Ensembl chr 1:20,801,129...20,804,720

G

interleukin 17B

multiple interactions

ferulic acid inhibits the reaction [Imiquimod results in decreased expression of IL17B mRNA]

NCBI chr18:61,821,006...61,825,609
Ensembl chr18:61,817,958...61,825,609

G

interleukin 17 receptor B

multiple interactions

ferulic acid inhibits the reaction [Imiquimod results in decreased expression of IL17RB mRNA]

NCBI chr14:29,718,125...29,730,853
Ensembl chr14:29,718,092...29,730,853

G

interleukin 18

multiple interactions

ferulic acid inhibits the reaction [Imiquimod results in increased expression of IL18 mRNA]

NCBI chr 9:50,466,000...50,493,141
Ensembl chr 9:50,466,127...50,493,140

G

interleukin 18 receptor accessory protein

multiple interactions

ferulic acid inhibits the reaction [Imiquimod results in increased expression of IL18RAP mRNA]

NCBI chr 1:40,554,548...40,590,867
Ensembl chr 1:40,554,522...40,590,865

G

interleukin 1 alpha

multiple interactions

ferulic acid inhibits the reaction [Imiquimod results in increased expression of IL1A mRNA]

NCBI chr 2:129,141,530...129,151,892
Ensembl chr 2:129,141,530...129,151,892

G

interleukin 1 beta

multiple interactions

ferulic acid inhibits the reaction [Imiquimod results in increased expression of IL1B mRNA]; ferulic acid inhibits the reaction [Imiquimod results in increased expression of IL1B protein]; ferulic acid inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]; ferulic acid inhibits the reaction [Silicon Dioxide results in increased expression of IL1B protein]

PMID:31054998 PMID:33140555 PMID:33428986

NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059

G

interleukin 1 family, member 10

multiple interactions

ferulic acid inhibits the reaction [Imiquimod results in decreased expression of IL1F10 mRNA]

NCBI chr 2:24,177,095...24,184,236
Ensembl chr 2:24,181,208...24,183,832

G

interleukin 20

multiple interactions

ferulic acid inhibits the reaction [Imiquimod results in increased expression of IL20 mRNA]

NCBI chr 1:130,834,722...130,839,033
Ensembl chr 1:130,834,722...130,839,188

G

interleukin 20 receptor beta

multiple interactions

ferulic acid inhibits the reaction [Imiquimod results in increased expression of IL20RB mRNA]

NCBI chr 9:100,339,772...100,368,526
Ensembl chr 9:100,339,772...100,368,841

G

interleukin 22 receptor, alpha 1

multiple interactions

ferulic acid inhibits the reaction [Imiquimod results in increased expression of IL22RA1 mRNA]

NCBI chr 4:135,455,470...135,482,694
Ensembl chr 4:135,455,483...135,479,451

G

interleukin 23, alpha subunit p19

multiple interactions

ferulic acid inhibits the reaction [Imiquimod results in increased expression of IL23A mRNA]; ferulic acid inhibits the reaction [Imiquimod results in increased expression of IL23A protein]

NCBI chr10:128,132,009...128,133,953
Ensembl chr10:128,132,008...128,134,621

G

interleukin 27

multiple interactions

ferulic acid inhibits the reaction [Imiquimod results in increased expression of IL27 mRNA]

NCBI chr 7:126,188,181...126,194,197
Ensembl chr 7:126,188,182...126,194,113

G

interleukin 33

multiple interactions

ferulic acid inhibits the reaction [Imiquimod results in increased expression of IL33 mRNA]

NCBI chr19:29,902,513...29,938,118
Ensembl chr19:29,902,514...29,938,118

G

interleukin 36A

multiple interactions

ferulic acid inhibits the reaction [Imiquimod results in increased expression of IL36A mRNA]

NCBI chr 2:24,105,429...24,115,713
Ensembl chr 2:24,105,430...24,115,714

G

interleukin 36B

multiple interactions

ferulic acid inhibits the reaction [Imiquimod results in increased expression of IL36B mRNA]

NCBI chr 2:24,043,184...24,050,115
Ensembl chr 2:24,043,173...24,050,531

G

interleukin 36G

multiple interactions

ferulic acid inhibits the reaction [Imiquimod results in increased expression of IL36G mRNA]

NCBI chr 2:24,076,488...24,083,579
Ensembl chr 2:24,076,488...24,083,580

G

interleukin 36 receptor antagonist

multiple interactions

ferulic acid inhibits the reaction [Imiquimod results in increased expression of IL36RN mRNA]

NCBI chr 2:24,166,966...24,172,444
Ensembl chr 2:24,166,966...24,173,438

G

interleukin 6

increases expression
multiple interactions

ferulic acid results in increased expression of IL6 mRNA
ferulic acid inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]; ferulic acid inhibits the reaction [Silicon Dioxide results in increased expression of IL6 protein]; ferulic acid inhibits the reaction [tyloxapol results in increased expression of IL6 mRNA]

PMID:21870829 PMID:33140555 PMID:33428986 PMID:37076581

NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979

G

interleukin 7

multiple interactions

ferulic acid inhibits the reaction [Imiquimod results in increased expression of IL7 mRNA]

NCBI chr 3:7,637,088...7,678,820
Ensembl chr 3:7,635,054...7,678,820

G

interleukin 7 receptor

multiple interactions

ferulic acid inhibits the reaction [Imiquimod results in increased expression of IL7R mRNA]

NCBI chr15:9,505,880...9,530,270
Ensembl chr15:9,505,874...9,530,262

G

interleukin 9 receptor

multiple interactions

ferulic acid inhibits the reaction [Imiquimod results in decreased expression of IL9R mRNA]

NCBI chr11:32,137,544...32,155,283
Ensembl chr11:32,137,541...32,150,279

G

interleukin-1 receptor-associated kinase 2

multiple interactions

ferulic acid inhibits the reaction [Imiquimod results in increased expression of IRAK2 mRNA]

NCBI chr 6:113,615,428...113,671,987
Ensembl chr 6:113,615,428...113,671,987

G

interleukin-1 receptor-associated kinase 3

multiple interactions

ferulic acid inhibits the reaction [Imiquimod results in increased expression of IRAK3 mRNA]

NCBI chr10:119,977,553...120,038,035
Ensembl chr10:119,977,553...120,038,035

G

jun proto-oncogene

multiple interactions

ferulic acid inhibits the reaction [Carbon Tetrachloride results in increased phosphorylation of and results in increased localization of JUN protein]

NCBI chr 4:94,937,273...94,940,459
Ensembl chr 4:94,937,271...94,940,459

G

lactate dehydrogenase A

multiple interactions

[Ascorbic Acid co-treated with alpha-Tocopherol co-treated with ferulic acid] inhibits the reaction [[Ozone co-treated with Oxygen] results in increased secretion of LDHA protein]

NCBI chr 7:46,491,698...46,505,051
Ensembl chr 7:46,490,899...46,505,051

G

mitogen-activated protein kinase 1

decreases activity
multiple interactions

ferulic acid results in decreased activity of MAPK1 protein
[resveratrol co-treated with Phytic Acid co-treated with ferulic acid co-treated with Quercetin] results in increased phosphorylation of MAPK1 protein

PMID:15363954 PMID:15486966 PMID:21203465

NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317

G

mitogen-activated protein kinase 3

decreases activity
multiple interactions

ferulic acid results in decreased activity of MAPK3 protein
[resveratrol co-treated with Phytic Acid co-treated with ferulic acid co-treated with Quercetin] results in increased phosphorylation of MAPK3 protein

PMID:15363954 PMID:15486966 PMID:21203465

NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991

G

mitogen-activated protein kinase 8

decreases activity
multiple interactions

ferulic acid results in decreased activity of MAPK8 protein
ferulic acid inhibits the reaction [Carbon Tetrachloride results in increased phosphorylation of MAPK8 protein]

PMID:15363954 PMID:21291945

NCBI chr14:33,099,855...33,169,213
Ensembl chr14:33,099,855...33,169,115

G

mitofusin 2

multiple interactions

ferulic acid inhibits the reaction [Streptozocin results in decreased expression of MFN2 protein]

NCBI chr 4:147,958,043...147,989,527
Ensembl chr 4:147,958,056...147,989,161

G

microRNA 101a

multiple interactions

[resveratrol co-treated with Phytic Acid co-treated with ferulic acid co-treated with Quercetin] results in increased expression of MIR101A mRNA

NCBI chr 4:101,204,142...101,204,224
Ensembl chr 4:101,204,142...101,204,224

G

microRNA 10a

multiple interactions

[resveratrol co-treated with Phytic Acid co-treated with ferulic acid co-treated with Quercetin] results in increased expression of MIR10A mRNA

NCBI chr11:96,207,991...96,208,100
Ensembl chr11:96,207,991...96,208,100

G

microRNA 17

multiple interactions

ferulic acid inhibits the reaction [Lipopolysaccharides results in decreased expression of MIR17 mRNA]; MIR17 mRNA affects the reaction [ferulic acid inhibits the reaction [Lipopolysaccharides results in decreased expression of BCL2 protein]]; MIR17 mRNA affects the reaction [ferulic acid inhibits the reaction [Lipopolysaccharides results in decreased phosphorylation of AKT1 protein]]; MIR17 mRNA affects the reaction [ferulic acid inhibits the reaction [Lipopolysaccharides results in increased cleavage of CASP3 protein]]; MIR17 mRNA affects the reaction [ferulic acid inhibits the reaction [Lipopolysaccharides results in increased expression of BAX protein]]; MIR17 mRNA affects the reaction [ferulic acid inhibits the reaction [Lipopolysaccharides results in increased expression of PTEN protein]]

NCBI chr14:115,281,103...115,281,186
Ensembl chr14:115,281,103...115,281,186

G

microRNA 181c

multiple interactions

[Resveratrol co-treated with Phytic Acid co-treated with ferulic acid co-treated with Quercetin] results in increased expression of MIR181C mRNA

NCBI chr 8:84,905,502...84,905,590
Ensembl chr 8:84,905,502...84,905,590

G

microRNA 200a

multiple interactions

ferulic acid inhibits the reaction [Thioacetamide results in decreased expression of MIR200A mRNA]

NCBI chr 4:156,139,353...156,139,442
Ensembl chr 4:156,139,353...156,139,442

G

microRNA 20b

multiple interactions

[Resveratrol co-treated with Phytic Acid co-treated with ferulic acid co-treated with Quercetin] results in decreased expression of MIR20B mRNA

NCBI chr X:51,830,990...51,831,069
Ensembl chr X:51,830,990...51,831,069

G

microRNA 214

multiple interactions

[Resveratrol co-treated with Phytic Acid co-treated with ferulic acid co-treated with Quercetin] results in increased expression of MIR214 mRNA

NCBI chr 1:162,050,937...162,051,046
Ensembl chr 1:162,050,937...162,051,046

G

microRNA 21a

multiple interactions
increases expression

[Resveratrol co-treated with Phytic Acid co-treated with ferulic acid co-treated with Quercetin] results in increased expression of MIR21 mRNA; ferulic acid inhibits the reaction [Thioacetamide results in increased expression of MIR21 mRNA]
ferulic acid results in increased expression of MIR21 mRNA

PMID:21203465 PMID:32278740

NCBI chr11:86,474,893...86,474,984
Ensembl chr11:86,474,893...86,474,984

G

microRNA 25

multiple interactions

[resveratrol co-treated with Phytic Acid co-treated with ferulic acid co-treated with Quercetin] results in increased expression of MIR25 mRNA

NCBI chr 5:138,163,583...138,163,666
Ensembl chr 5:138,163,583...138,163,666

G

microRNA 27b

multiple interactions

[resveratrol co-treated with Phytic Acid co-treated with ferulic acid co-treated with Quercetin] results in decreased expression of MIR27B mRNA

NCBI chr13:63,448,526...63,448,598
Ensembl chr13:63,448,526...63,448,598

G

microRNA 30a

multiple interactions

ferulic acid inhibits the reaction [Thioacetamide results in decreased expression of MIR30A mRNA]

NCBI chr 1:23,311,350...23,311,420
Ensembl chr 1:23,311,350...23,311,420

G

microRNA 324

multiple interactions

[Resveratrol co-treated with Phytic Acid co-treated with ferulic acid co-treated with Quercetin] results in increased expression of MIR324 mRNA

NCBI chr11:69,902,869...69,902,957
Ensembl chr11:69,902,869...69,902,957

G

microRNA 339

multiple interactions

[Resveratrol co-treated with Phytic Acid co-treated with ferulic acid co-treated with Quercetin] results in increased expression of MIR339 mRNA

NCBI chr 5:139,355,405...139,355,500
Ensembl chr 5:139,355,405...139,355,500

G

microRNA 450-1

multiple interactions

[Resveratrol co-treated with Phytic Acid co-treated with ferulic acid co-treated with Quercetin] results in increased expression of MIR450A1 mRNA

NCBI chr X:52,137,031...52,137,121
Ensembl chr X:52,137,031...52,137,121

G

microRNA 760

multiple interactions

[Resveratrol co-treated with Phytic Acid co-treated with ferulic acid co-treated with Quercetin] results in increased expression of MIR760 mRNA

NCBI chr 3:122,087,234...122,087,352
Ensembl chr 3:122,087,234...122,087,352

G

myeloperoxidase

multiple interactions

ferulic acid inhibits the reaction [Lipopolysaccharides results in increased activity of MPO protein]

NCBI chr11:87,684,610...87,695,238
Ensembl chr11:87,684,407...87,695,239

G

nuclear factor, erythroid derived 2, like 2

multiple interactions
increases expression

ferulic acid inhibits the reaction [sodium arsenate results in decreased expression of NFE2L2 mRNA]
[Ascorbic Acid co-treated with alpha-Tocopherol co-treated with ferulic acid] promotes the reaction [[Ozone co-treated with Oxygen] results in increased localization of NFE2L2 protein]
ferulic acid results in increased expression of NFE2L2 mRNA

PMID:26270818 PMID:30503583

NCBI chr 2:75,505,860...75,535,007
Ensembl chr 2:75,505,857...75,534,985

G

nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha

multiple interactions

ferulic acid inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein]

NCBI chr12:55,536,194...55,539,432
Ensembl chr12:55,536,195...55,539,432

G

nitric oxide synthase 2, inducible

multiple interactions

[ferulic acid results in decreased expression of NOS2 protein] which results in decreased chemical synthesis of Nitric Oxide; ferulic acid inhibits the reaction [Carbon Tetrachloride results in increased expression of NOS2 mRNA]; ferulic acid inhibits the reaction [Carbon Tetrachloride results in increased expression of NOS2 protein]; ferulic acid inhibits the reaction [Lipopolysaccharides results in increased activity of NOS2 protein]; ferulic acid inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; ferulic acid inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]

PMID:21291945 PMID:22366099

NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080

G

NAD(P)H dehydrogenase, quinone 1

multiple interactions

Ferulic acid reverses the reaction[methotrexate decreases mRNA in the liver]

RGD

NCBI chr 8:108,114,856...108,139,012
Ensembl chr 8:108,114,857...108,129,838

G

phosphogluconate dehydrogenase

decreases activity

ferulic acid results in decreased activity of PGD protein

NCBI chr 4:149,234,448...149,251,162
Ensembl chr 4:149,234,448...149,251,228

G

phosphoinositide-3-kinase regulatory subunit 1

increases expression

ferulic acid results in increased expression of PIK3R1 mRNA

NCBI chr13:101,817,269...101,904,725
Ensembl chr13:101,817,071...101,904,725

G

peroxisome proliferator activated receptor gamma

increases expression
multiple interactions

ferulic acid results in increased expression of PPARG mRNA
ferulic acid inhibits the reaction [sodium arsenite results in decreased expression of PPARG protein]

PMID:21870829 PMID:37393015

NCBI chr 6:115,337,828...115,467,365
Ensembl chr 6:115,337,912...115,467,360

G

peroxisome proliferative activated receptor, gamma, coactivator 1 alpha

decreases expression
multiple interactions

ferulic acid results in decreased expression of PPARGC1A mRNA
ferulic acid inhibits the reaction [Streptozocin results in decreased expression of PPARGC1A protein]
ferulic acid inhibits the reaction [sodium arsenate results in increased expression of PPARGC1A mRNA]

PMID:30503583 PMID:31029786

NCBI chr 5:51,611,591...52,273,316
Ensembl chr 5:51,611,592...51,725,068

G

phosphatase and tensin homolog

multiple interactions

ferulic acid inhibits the reaction [Lipopolysaccharides results in increased expression of PTEN protein]; MIR17 mRNA affects the reaction [ferulic acid inhibits the reaction [Lipopolysaccharides results in increased expression of PTEN protein]]; PTEN protein inhibits the reaction [ferulic acid inhibits the reaction [Lipopolysaccharides results in decreased expression of BCL2 protein]]; PTEN protein inhibits the reaction [ferulic acid inhibits the reaction [Lipopolysaccharides results in decreased phosphorylation of AKT1 protein]]; PTEN protein inhibits the reaction [ferulic acid inhibits the reaction [Lipopolysaccharides results in increased cleavage of CASP3 protein]]; PTEN protein inhibits the reaction [ferulic acid inhibits the reaction [Lipopolysaccharides results in increased expression of BAX protein]]; PTEN protein inhibits the reaction [ferulic acid inhibits the reaction [Lipopolysaccharides results in increased expression of PTEN protein]]

NCBI chr19:32,734,977...32,803,560
Ensembl chr19:32,734,897...32,803,560

G

prostaglandin-endoperoxide synthase 1

decreases expression

ferulic acid results in decreased expression of PTGS1 mRNA

NCBI chr 2:36,106,758...36,142,287
Ensembl chr 2:36,120,438...36,142,284

G

prostaglandin-endoperoxide synthase 2

decreases expression
multiple interactions

ferulic acid results in decreased expression of PTGS2 protein
ferulic acid inhibits the reaction [Nicotine results in increased expression of PTGS2 protein]
ferulic acid analog inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; ferulic acid inhibits the reaction [Carbon Tetrachloride results in increased expression of PTGS2 mRNA]; ferulic acid inhibits the reaction [Carbon Tetrachloride results in increased expression of PTGS2 protein]

PMID:15841493 PMID:17436566 PMID:18068289 PMID:21291945

NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978

G

RB transcriptional corepressor 1

decreases phosphorylation

ferulic acid results in decreased phosphorylation of RB1 protein

PMID:15363954 PMID:15486966

NCBI chr14:73,430,298...73,563,446
Ensembl chr14:73,421,113...73,563,262

G

v-rel reticuloendotheliosis viral oncogene homolog A (avian)

multiple interactions

ferulic acid inhibits the reaction [Carbon Tetrachloride results in increased activity of and results in increased localization of RELA protein]; ferulic acid inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of RELA protein]
[Ascorbic Acid co-treated with alpha-Tocopherol co-treated with ferulic acid] inhibits the reaction [[Ozone co-treated with Oxygen] results in increased localization of RELA protein]

PMID:21291945 PMID:26270818 PMID:33140555

NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158

G

stearoyl-Coenzyme A desaturase 2

decreases expression

ferulic acid results in decreased expression of SCD mRNA

NCBI chr19:44,282,115...44,295,303
Ensembl chr19:44,282,113...44,295,303

G

solute carrier family 2 (facilitated glucose transporter), member 2

multiple interactions
increases expression

ferulic acid inhibits the reaction [sodium arsenite results in decreased expression of SLC2A2 protein]
ferulic acid results in increased expression of SLC2A2 protein

NCBI chr 3:28,752,052...28,782,510
Ensembl chr 3:28,752,052...28,785,508

G

solute carrier family 2 (facilitated glucose transporter), member 4

increases expression

ferulic acid results in increased expression of SLC2A4 mRNA

NCBI chr11:69,833,112...69,839,040
Ensembl chr11:69,833,365...69,839,014

G

SMAD family member 3

multiple interactions

ferulic acid inhibits the reaction [Thioacetamide results in increased phosphorylation of SMAD3 protein]

NCBI chr 9:63,554,048...63,665,276
Ensembl chr 9:63,554,049...63,665,276

G

snail family zinc finger 2

multiple interactions

ferulic acid inhibits the reaction [Silicon Dioxide results in increased expression of SNAI2 protein]

NCBI chr16:14,523,716...14,527,259
Ensembl chr16:14,523,716...14,527,249

G

steroidogenic acute regulatory protein

multiple interactions
increases expression

ferulic acid analog promotes the reaction [Colforsin results in increased expression of STAR mRNA]; ferulic acid analog promotes the reaction [Colforsin results in increased expression of STAR protein]; ferulic acid inhibits the reaction [sodium arsenate results in decreased expression of STAR mRNA]
ferulic acid results in increased expression of STAR mRNA

PMID:30503583 PMID:36279966

NCBI chr 8:26,298,502...26,306,010
Ensembl chr 8:26,296,583...26,306,010

G

sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 1

increases expression

ferulic acid results in increased expression of SULT2A1 mRNA

NCBI chr 7:13,530,171...13,571,335
Ensembl chr 7:13,530,171...13,571,334

G

transforming growth factor, beta 1

multiple interactions

ferulic acid inhibits the reaction [Thioacetamide results in increased expression of TGFB1 protein]

NCBI chr 7:25,386,406...25,404,503
Ensembl chr 7:25,386,427...25,404,502

G

toll-like receptor 2

multiple interactions

ferulic acid inhibits the reaction [Carbon Tetrachloride results in increased expression of TLR2 mRNA]; ferulic acid inhibits the reaction [Carbon Tetrachloride results in increased expression of TLR2 protein]

NCBI chr 3:83,743,579...83,749,045
Ensembl chr 3:83,743,579...83,749,074

G

toll-like receptor 4

multiple interactions

ferulic acid inhibits the reaction [Carbon Tetrachloride results in increased expression of TLR4 mRNA]; ferulic acid inhibits the reaction [Carbon Tetrachloride results in increased expression of TLR4 protein]; ferulic acid inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 protein]

PMID:21291945 PMID:33140555

NCBI chr 4:66,745,788...66,765,338
Ensembl chr 4:66,745,821...66,848,521

G

tumor necrosis factor

increases expression
multiple interactions

ferulic acid results in increased expression of TNF mRNA
ferulic acid inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF mRNA]; ferulic acid inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF protein]; ferulic acid inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; ferulic acid inhibits the reaction [Silicon Dioxide results in increased expression of TNF protein]; ferulic acid inhibits the reaction [sodium arsenite results in increased expression of TNF protein]; ferulic acid inhibits the reaction [tyloxapol results in increased expression of TNF mRNA]

PMID:21291945 PMID:21870829 PMID:33140555 PMID:33428986 PMID:37076581 More...

NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983

G

tyrosinase

increases oxidation
multiple interactions

TYR protein results in increased oxidation of ferulic acid
[TYR protein results in increased oxidation of ferulic acid] which results in decreased abundance of Glutathione

NCBI chr 7:87,073,979...87,142,637
Ensembl chr 7:87,073,979...87,142,720

G

UDP glycosyltransferase 1 family, polypeptide A10

increases glucuronidation

UGT1A10 protein results in increased glucuronidation of ferulic acid

NCBI chr 1:87,983,133...88,147,724
Ensembl chr 1:87,983,110...88,146,726

G

UDP glucuronosyltransferase 1 family, polypeptide A2

increases glucuronidation

UGT1A3 protein results in increased glucuronidation of ferulic acid

NCBI chr 1:88,128,333...88,147,724
Ensembl chr 1:88,128,323...88,146,719

G

vascular endothelial growth factor A

multiple interactions

ferulic acid inhibits the reaction [tyloxapol results in increased expression of VEGFA mRNA]

NCBI chr17:46,327,919...46,343,303
Ensembl chr17:46,327,919...46,343,295

G

vimentin

multiple interactions

ferulic acid inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of VIM protein]
ferulic acid inhibits the reaction [Silicon Dioxide results in increased expression of VIM protein]

PMID:31584213 PMID:33428986

NCBI chr 2:13,579,122...13,587,637
Ensembl chr 2:13,578,738...13,587,637

Forsythiaside

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

BCL2-associated X protein

multiple interactions

forsythiaside inhibits the reaction [amyloid beta-protein (25-35) results in increased expression of BAX protein]; Rimonabant inhibits the reaction [forsythiaside inhibits the reaction [amyloid beta-protein (25-35) results in increased expression of BAX protein]]

NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322

G

B cell leukemia/lymphoma 2

multiple interactions

forsythiaside inhibits the reaction [amyloid beta-protein (25-35) results in decreased expression of BCL2 protein]; Rimonabant inhibits the reaction [forsythiaside inhibits the reaction [amyloid beta-protein (25-35) results in decreased expression of BCL2 protein]]

NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004

G

caspase 3

multiple interactions

forsythiaside inhibits the reaction [amyloid beta-protein (25-35) results in increased cleavage of CASP3 protein]; Rimonabant inhibits the reaction [forsythiaside inhibits the reaction [amyloid beta-protein (25-35) results in increased cleavage of CASP3 protein]]

NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724

G

monoglyceride lipase

multiple interactions

forsythiaside inhibits the reaction [amyloid beta-protein (25-35) results in increased expression of MGLL protein]

NCBI chr 6:88,701,397...88,805,342
Ensembl chr 6:88,701,394...88,805,342

G

prostaglandin-endoperoxide synthase 2

multiple interactions

forsythiaside inhibits the reaction [amyloid beta-protein (25-35) results in increased expression of PTGS2 protein]; Rimonabant inhibits the reaction [forsythiaside inhibits the reaction [amyloid beta-protein (25-35) results in increased expression of PTGS2 protein]]

NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978

G

tumor necrosis factor

multiple interactions

forsythiaside inhibits the reaction [amyloid beta-protein (25-35) results in increased expression of TNF protein]; Rimonabant inhibits the reaction [forsythiaside inhibits the reaction [amyloid beta-protein (25-35) results in increased expression of TNF protein]]

NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983

methyl caffeate

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

thymoma viral proto-oncogene 1

decreases phosphorylation

methyl caffeate analog results in decreased phosphorylation of AKT1 protein

NCBI chr12:112,620,260...112,641,266
Ensembl chr12:112,620,255...112,641,318

G

BCL2-associated X protein

increases expression

methyl caffeate results in increased expression of BAX protein

NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322

G

B cell leukemia/lymphoma 2

multiple interactions

methyl caffeate binds to and results in decreased expression of BCL2 protein

NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004

G

BH3 interacting domain death agonist

increases expression

methyl caffeate results in increased expression of BID protein

NCBI chr 6:120,870,080...120,894,074
Ensembl chr 6:120,868,891...120,893,814

G

caspase 3

increases activity

methyl caffeate results in increased activity of CASP3 protein

NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724

G

cyclin dependent kinase inhibitor 1A

increases expression

methyl caffeate analog results in increased expression of CDKN1A protein

NCBI chr17:29,309,953...29,319,696
Ensembl chr17:29,309,950...29,319,701

G

kinase insert domain protein receptor

decreases expression

methyl caffeate analog results in decreased expression of KDR protein

NCBI chr 5:76,093,487...76,139,880
Ensembl chr 5:76,093,487...76,139,118

G

mitogen-activated protein kinase 1

decreases phosphorylation

methyl caffeate analog results in decreased phosphorylation of MAPK1 protein

NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317

G

mitogen-activated protein kinase 3

decreases phosphorylation

methyl caffeate analog results in decreased phosphorylation of MAPK3 protein

NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991

G

transformed mouse 3T3 cell double minute 2

affects binding

methyl caffeate binds to MDM2 protein

NCBI chr10:117,524,780...117,546,663
Ensembl chr10:117,524,780...117,546,663

G

matrix metallopeptidase 2

multiple interactions

methyl caffeate analog results in decreased expression of and results in decreased activity of MMP2 protein

NCBI chr 8:93,553,920...93,580,049
Ensembl chr 8:93,553,919...93,580,048

G

matrix metallopeptidase 9

multiple interactions

methyl caffeate analog results in decreased expression of and results in decreased activity of MMP9 protein

NCBI chr 2:164,782,246...164,797,770
Ensembl chr 2:164,782,700...164,797,770

G

mechanistic target of rapamycin kinase

decreases phosphorylation

methyl caffeate analog results in decreased phosphorylation of MTOR protein

NCBI chr 4:148,533,039...148,642,142
Ensembl chr 4:148,533,068...148,642,140

G

poly (ADP-ribose) polymerase family, member 1

multiple interactions

methyl caffeate binds to and results in increased activity of PARP1 protein

NCBI chr 1:180,396,456...180,428,564
Ensembl chr 1:180,396,489...180,428,819

G

transformation related protein 53

increases expression

methyl caffeate analog results in increased expression of TP53 protein

NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699

G

vascular endothelial growth factor A

multiple interactions

methyl caffeate analog results in decreased expression of and results in decreased secretion of VEGFA protein

NCBI chr17:46,327,919...46,343,303
Ensembl chr17:46,327,919...46,343,295

Nitecapone

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

catechol-O-methyltransferase

decreases activity

nitecapone results in decreased activity of COMT protein

NCBI chr16:18,225,632...18,247,006
Ensembl chr16:18,225,636...18,245,602

phenethyl caffeate

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

alpha-2-macroglobulin

multiple interactions

caffeic acid phenethyl ester inhibits the reaction [Diethylnitrosamine results in decreased expression of A2M mRNA]

NCBI chr 6:121,612,920...121,656,197
Ensembl chr 6:121,612,335...121,656,186

G

arylalkylamine N-acetyltransferase

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of AANAT mRNA

NCBI chr11:116,482,547...116,489,022
Ensembl chr11:116,477,258...116,488,506

G

ATP-binding cassette, sub-family A member 5

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of ABCA5 mRNA

NCBI chr11:110,160,195...110,228,542
Ensembl chr11:110,160,195...110,228,542

G

ATP-binding cassette, sub-family C member 1

decreases activity

caffeic acid phenethyl ester metabolite results in decreased activity of ABCC1 protein

NCBI chr16:14,179,317...14,292,743
Ensembl chr16:14,179,422...14,293,601

G

ATP-binding cassette, sub-family C member 3

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of ABCC3 mRNA

NCBI chr11:94,234,121...94,283,843
Ensembl chr11:94,234,121...94,283,823

G

aggrecan

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of ACAN mRNA

NCBI chr 7:78,702,974...78,764,847
Ensembl chr 7:78,703,231...78,764,847

G

acyl-CoA thioesterase 2

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of ACOT2 mRNA

NCBI chr12:84,034,635...84,040,651
Ensembl chr12:84,034,635...84,040,647

G

acid phosphatase 5, tartrate resistant

multiple interactions

caffeic acid phenethyl ester inhibits the reaction [Dexamethasone results in increased activity of ACP5 protein]

NCBI chr 9:22,038,023...22,047,042
Ensembl chr 9:22,038,023...22,047,007

G

adenosine deaminase

multiple interactions

caffeic acid phenethyl ester inhibits the reaction [Methotrexate results in increased activity of ADA protein]

NCBI chr 2:163,565,703...163,592,154
Ensembl chr 2:163,568,504...163,592,159

G

a disintegrin and metallopeptidase domain 7

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of ADAM7 mRNA

NCBI chr14:68,734,785...68,771,138
Ensembl chr14:68,734,785...68,771,190

G

adenylate cyclase 2

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of ADCY2 mRNA

NCBI chr13:68,768,162...69,147,719
Ensembl chr13:68,768,162...69,147,660

G

adrenergic receptor, alpha 1d

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of ADRA1D mRNA

NCBI chr 2:131,387,277...131,404,417
Ensembl chr 2:131,387,770...131,404,203

G

ArfGAP with GTPase domain, ankyrin repeat and PH domain 2

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of AGAP2 mRNA

NCBI chr10:126,911,154...126,929,039
Ensembl chr10:126,911,153...126,929,038

G

aryl-hydrocarbon receptor

multiple interactions

caffeic acid phenethyl ester promotes the reaction [Nitrogen Mustard Compounds results in decreased expression of AHR protein]

NCBI chr12:35,547,978...35,584,988
Ensembl chr12:35,547,973...35,585,037

G

aminoacyl tRNA synthetase complex-interacting multifunctional protein 1

multiple interactions

caffeic acid phenethyl ester inhibits the reaction [AIMP1 protein results in increased expression of IL12B mRNA]

NCBI chr 3:132,366,259...132,390,151
Ensembl chr 3:132,366,242...132,390,131

G

A kinase anchor protein 9

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of AKAP9 mRNA

NCBI chr 5:3,977,410...4,130,204
Ensembl chr 5:3,978,054...4,131,310

G

aldo-keto reductase family 1 member B

decreases activity

caffeic acid phenethyl ester results in decreased activity of AKR1B1 protein

NCBI chr 6:34,280,865...34,294,424
Ensembl chr 6:34,279,369...34,294,413

G

aldo-keto reductase family 1, member B10

decreases activity

caffeic acid phenethyl ester results in decreased activity of AKR1B10 protein

NCBI chr 6:34,361,182...34,373,884
Ensembl chr 6:34,361,153...34,373,885

G

aldo-keto reductase family 1, member C18

decreases activity

caffeic acid phenethyl ester results in decreased activity of AKR1C3 protein

NCBI chr13:4,182,614...4,200,645
Ensembl chr13:4,182,614...4,200,653

G

aldo-keto reductase family 1, member C20

decreases activity

caffeic acid phenethyl ester results in decreased activity of AKR1C1 protein

NCBI chr13:4,536,855...4,573,353
Ensembl chr13:4,536,848...4,573,344

G

aldo-keto reductase family 1, member C21

decreases activity

caffeic acid phenethyl ester results in decreased activity of AKR1C2 protein

NCBI chr13:4,624,074...4,636,542
Ensembl chr13:4,624,074...4,636,540

G

aldo-keto reductase family 1, member C6

decreases activity

caffeic acid phenethyl ester results in decreased activity of AKR1C4 protein

NCBI chr13:4,484,354...4,507,529
Ensembl chr13:4,484,305...4,507,876

G

thymoma viral proto-oncogene 1

affects phosphorylation

caffeic acid phenethyl ester analog affects the phosphorylation of AKT1 protein

NCBI chr12:112,620,260...112,641,266
Ensembl chr12:112,620,255...112,641,318

G

aldehyde dehydrogenase family 1, subfamily A2

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of ALDH1A2 mRNA

NCBI chr 9:71,123,071...71,203,525
Ensembl chr 9:71,123,071...71,203,525

G

alkaline phosphatase, liver/bone/kidney

multiple interactions

caffeic acid phenethyl ester inhibits the reaction [Carbon Tetrachloride results in increased activity of ALPL protein]
caffeic acid phenethyl ester inhibits the reaction [Dexamethasone results in decreased expression of ALPL protein]

PMID:18436364 PMID:28363435

NCBI chr 4:137,469,042...137,523,695
Ensembl chr 4:137,469,044...137,523,695

G

ankyrin repeat domain 17

multiple interactions

caffeic acid phenethyl ester inhibits the reaction [Diethylnitrosamine results in increased expression of ANKRD17 mRNA]

NCBI chr 5:90,375,025...90,517,133
Ensembl chr 5:90,375,025...90,514,436

G

arrestin, beta 1

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of ARRB1 mRNA

NCBI chr 7:99,184,356...99,255,979
Ensembl chr 7:99,184,673...99,255,978

G

activating transcription factor 6

multiple interactions

[caffeic acid phenethyl ester co-treated with Dietary Fats] results in decreased expression of ATF6 mRNA; GW 4064 inhibits the reaction [[caffeic acid phenethyl ester co-treated with Dietary Fats] results in decreased expression of ATF6 mRNA]

NCBI chr 1:170,532,026...170,696,414
Ensembl chr 1:170,532,243...170,695,340

G

antioxidant 1 copper chaperone

multiple interactions

caffeic acid phenethyl ester inhibits the reaction [Diethylnitrosamine results in increased expression of ATOX1 mRNA]

NCBI chr11:55,337,463...55,352,034
Ensembl chr11:55,337,467...55,352,065

G

AXL receptor tyrosine kinase

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of AXL mRNA

NCBI chr 7:25,455,925...25,488,502
Ensembl chr 7:25,456,698...25,488,130

G

BCL2-associated X protein

multiple interactions

[Benzo(a)pyrene co-treated with caffeic acid phenethyl ester] results in increased expression of BAX mRNA

NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322

G

breast cancer anti-estrogen resistance 1

decreases phosphorylation

caffeic acid phenethyl ester results in decreased phosphorylation of BCAR1 protein

NCBI chr 8:112,437,106...112,470,481
Ensembl chr 8:112,437,106...112,470,441

G

B cell leukemia/lymphoma 2

multiple interactions

caffeic acid phenethyl ester inhibits the reaction [Cadmium Chloride results in decreased expression of BCL2 protein]

NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004

G

biglycan

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of BGN mRNA

NCBI chr X:72,527,207...72,539,542
Ensembl chr X:72,527,208...72,539,539

G

baculoviral IAP repeat-containing 2

decreases expression

caffeic acid phenethyl ester results in decreased expression of BIRC2 protein

NCBI chr 9:7,818,227...7,837,123
Ensembl chr 9:7,818,228...7,837,065

G

baculoviral IAP repeat-containing 3

decreases expression

caffeic acid phenethyl ester results in decreased expression of BIRC3 protein

NCBI chr 9:7,848,698...7,873,199
Ensembl chr 9:7,848,700...7,873,187

G

calcium channel, voltage-dependent, P/Q type, alpha 1A subunit

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of CACNA1A mRNA

NCBI chr 8:85,065,257...85,366,880
Ensembl chr 8:85,065,268...85,366,875

G

calcium channel, voltage-dependent, T type, alpha 1H subunit

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of CACNA1H mRNA

NCBI chr17:25,593,259...25,655,308
Ensembl chr17:25,593,259...25,652,759

G

calcium/calmodulin-dependent protein kinase II, delta

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of CAMK2D mRNA

NCBI chr 3:126,389,136...126,639,975
Ensembl chr 3:126,389,951...126,639,975

G

calpain 8

multiple interactions

caffeic acid phenethyl ester inhibits the reaction [Diethylnitrosamine results in decreased expression of CAPN8 mRNA]

NCBI chr 1:182,392,314...182,462,021
Ensembl chr 1:182,392,572...182,459,917

G

carbonic anhydrase 3

multiple interactions

caffeic acid phenethyl ester inhibits the reaction [Diethylnitrosamine results in decreased expression of CAR3 mRNA]

NCBI chr 3:14,928,598...14,937,441
Ensembl chr 3:14,928,572...14,937,583

G

carbonic anhydrase 4

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of CAR4 mRNA

NCBI chr11:84,848,580...84,856,880
Ensembl chr11:84,848,612...84,856,870

G

caspase 1

decreases expression

caffeic acid phenethyl ester results in decreased expression of CASP1 protein

NCBI chr 9:5,298,517...5,307,281
Ensembl chr 9:5,298,508...5,307,290

G

caspase 3

decreases activity
multiple interactions
increases activity

caffeic acid phenethyl ester results in decreased activity of CASP3 protein
caffeic acid phenethyl ester inhibits the reaction [Cadmium Chloride results in increased expression of and results in increased activity of CASP3 protein]; caffeic acid phenethyl ester inhibits the reaction [Carbon Tetrachloride results in increased activity of CASP3 protein]
caffeic acid phenethyl ester inhibits the reaction [Dexamethasone results in increased activity of CASP3 protein]
caffeic acid phenethyl ester analog results in increased activity of CASP3 protein

PMID:15469948 PMID:18436364 PMID:28363435 PMID:32125059 PMID:34743973

NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724

G

caspase 8

multiple interactions

caffeic acid phenethyl ester inhibits the reaction [Carbon Tetrachloride results in increased activity of CASP8 protein]

NCBI chr 1:58,834,553...58,886,663
Ensembl chr 1:58,834,533...58,886,662

G

caspase 9

multiple interactions

caffeic acid phenethyl ester inhibits the reaction [Cadmium Chloride results in increased expression of and results in increased activity of CASP9 protein]

NCBI chr 4:141,520,923...141,543,289
Ensembl chr 4:141,520,923...141,543,287

G

catalase

multiple interactions

caffeic acid phenethyl ester inhibits the reaction [Doxorubicin results in decreased activity of CAT protein]; caffeic acid phenethyl ester promotes the reaction [Doxorubicin results in increased activity of CAT protein]
caffeic acid phenethyl ester inhibits the reaction [Bleomycin results in decreased expression of CAT protein]; caffeic acid phenethyl ester inhibits the reaction [Carbon Tetrachloride results in decreased activity of CAT protein]

PMID:14745846 PMID:15369732 PMID:18436364 PMID:23570914

NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505

G

C-C motif chemokine ligand 2

multiple interactions

caffeic acid phenethyl ester inhibits the reaction [arsenite results in decreased expression of CCL2 mRNA]

NCBI chr11:81,926,403...81,928,278
Ensembl chr11:81,926,397...81,928,279

G

C-C motif chemokine ligand 5

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of CCL5 mRNA

NCBI chr11:83,416,604...83,421,344
Ensembl chr11:83,416,604...83,421,344

G

cyclin B1

decreases expression

caffeic acid phenethyl ester results in decreased expression of CCNB1 protein

NCBI chr13:100,915,247...100,922,994
Ensembl chr13:100,915,158...100,923,078

G

cyclin D1

multiple interactions

[Benzo(a)pyrene co-treated with caffeic acid phenethyl ester] results in decreased expression of CCND1 mRNA; caffeic acid phenethyl ester inhibits the reaction [sodium arsenite results in increased expression of CCND1 protein]

PMID:20420878 PMID:24289642

NCBI chr 7:144,483,668...144,493,568
Ensembl chr 7:144,483,668...144,493,662

G

cyclin E1

multiple interactions

caffeic acid phenethyl ester inhibits the reaction [CDK2 protein binds to CCNE1 protein]
[Tretinoin co-treated with caffeic acid phenethyl ester] inhibits the reaction [CDK2 protein binds to CCNE1 protein]

PMID:15885897 PMID:16766008

NCBI chr 7:37,797,409...37,806,915
Ensembl chr 7:37,797,409...37,806,959

G

CD14 antigen

multiple interactions
increases expression

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of CD14 mRNA
caffeic acid phenethyl ester promotes the reaction [Tretinoin results in increased expression of CD14 protein]
caffeic acid phenethyl ester results in increased expression of CD14 protein

PMID:16766008 PMID:20360939

NCBI chr18:36,858,117...36,859,868
Ensembl chr18:36,858,120...36,859,851

G

CD151 antigen

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of CD151 mRNA

NCBI chr 7:141,047,275...141,051,394
Ensembl chr 7:141,047,305...141,051,386

G

CD86 antigen

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of CD86 mRNA

NCBI chr16:36,389,318...36,486,439
Ensembl chr16:36,424,231...36,486,443

G

cyclin dependent kinase 1

decreases expression

caffeic acid phenethyl ester results in decreased expression of CDK1 protein

NCBI chr10:69,170,976...69,188,742
Ensembl chr10:69,170,976...69,188,768

G

cyclin dependent kinase 2

multiple interactions

caffeic acid phenethyl ester inhibits the reaction [CDK2 protein binds to CCNE1 protein]
[Tretinoin co-treated with caffeic acid phenethyl ester] inhibits the reaction [CDK2 protein binds to CCNE1 protein]

PMID:15885897 PMID:16766008

NCBI chr10:128,533,807...128,540,920
Ensembl chr10:128,533,808...128,540,900

G

cyclin dependent kinase inhibitor 1A

increases expression
multiple interactions

caffeic acid phenethyl ester results in increased expression of CDKN1A protein
[Benzo(a)pyrene co-treated with caffeic acid phenethyl ester] results in increased expression of CDKN1A mRNA; caffeic acid phenethyl ester inhibits the reaction [Folic Acid results in increased expression of CDKN1A protein]; Tretinoin promotes the reaction [caffeic acid phenethyl ester results in increased expression of CDKN1A protein]

PMID:15885897 PMID:16766008 PMID:24289642 PMID:26056802

NCBI chr17:29,309,953...29,319,696
Ensembl chr17:29,309,950...29,319,701

G

cyclin dependent kinase inhibitor 1B

increases expression
multiple interactions

caffeic acid phenethyl ester results in increased expression of CDKN1B protein
caffeic acid phenethyl ester inhibits the reaction [Folic Acid results in increased expression of CDKN1B protein]

PMID:15885897 PMID:26056802

NCBI chr 6:134,897,364...134,902,488
Ensembl chr 6:134,897,364...134,902,476

G

cyclin dependent kinase inhibitor 2A

increases expression
multiple interactions

caffeic acid phenethyl ester results in increased expression of CDKN2A protein
caffeic acid phenethyl ester inhibits the reaction [Diethylnitrosamine results in decreased expression of CDKN2A mRNA]

PMID:15885897 PMID:20360939

NCBI chr 4:89,192,710...89,212,856
Ensembl chr 4:89,192,708...89,212,890

G

cyclin dependent kinase inhibitor 2C

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of CDKN2C mRNA

NCBI chr 4:109,518,073...109,523,953
Ensembl chr 4:109,518,073...109,524,386

G

CEA cell adhesion molecule 10

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in increased expression of CEACAM10 mRNA

NCBI chr 7:24,476,592...24,484,081
Ensembl chr 7:24,476,631...24,484,082

G

CCAAT/enhancer binding protein epsilon

multiple interactions
increases expression

Tretinoin promotes the reaction [caffeic acid phenethyl ester results in increased expression of CEBPE protein]

NCBI chr14:54,947,823...54,949,604
Ensembl chr14:54,947,817...54,949,631

G

ceramide synthase 2

multiple interactions

[caffeic acid phenethyl ester co-treated with Dietary Fats] results in decreased expression of CERS2 mRNA; GW 4064 inhibits the reaction [[caffeic acid phenethyl ester co-treated with Dietary Fats] results in decreased expression of CERS2 mRNA]; NR1H4 protein affects the reaction [[caffeic acid phenethyl ester co-treated with Dietary Fats] results in decreased expression of CERS2 mRNA]

NCBI chr 3:95,222,077...95,230,910
Ensembl chr 3:95,222,102...95,230,910

G

ceramide synthase 4

multiple interactions

[caffeic acid phenethyl ester co-treated with Dietary Fats] results in decreased expression of CERS4 mRNA; GW 4064 inhibits the reaction [[caffeic acid phenethyl ester co-treated with Dietary Fats] results in decreased expression of CERS4 mRNA]; NR1H4 protein affects the reaction [[caffeic acid phenethyl ester co-treated with Dietary Fats] results in decreased expression of CERS4 mRNA]

NCBI chr 8:4,542,863...4,579,603
Ensembl chr 8:4,543,026...4,581,680

G

cholinergic receptor nicotinic alpha 2 subunit

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of CHRNA2 mRNA

NCBI chr14:66,370,685...66,390,397
Ensembl chr14:66,372,488...66,390,397

G

cholinergic receptor, nicotinic, epsilon polypeptide

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in increased expression of CHRNE mRNA

NCBI chr11:70,505,709...70,510,074
Ensembl chr11:70,505,709...70,510,042

G

chloride channel, voltage-sensitive 1

multiple interactions

caffeic acid phenethyl ester inhibits the reaction [Diethylnitrosamine results in increased expression of CLCN1 mRNA]

NCBI chr 6:42,263,552...42,292,693
Ensembl chr 6:42,263,619...42,292,690

G

claudin 2

multiple interactions
decreases expression

Cantharidin inhibits the reaction [caffeic acid phenethyl ester results in decreased expression of CLDN2 protein]; Chloroquine inhibits the reaction [caffeic acid phenethyl ester results in decreased expression of CLDN2 protein]; CLDN2 protein inhibits the reaction [caffeic acid phenethyl ester results in increased susceptibility to and results in increased activity of Doxorubicin]
caffeic acid phenethyl ester results in decreased expression of CLDN2 mRNA; caffeic acid phenethyl ester results in decreased expression of CLDN2 protein

NCBI chr X:138,701,552...138,712,135
Ensembl chr X:138,701,577...138,712,135

G

claudin 7

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of CLDN7 mRNA

NCBI chr11:69,855,605...69,858,712
Ensembl chr11:69,855,605...69,858,711

G

chloride intracellular channel 5

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of CLIC5 mRNA

NCBI chr17:44,445,671...44,591,059
Ensembl chr17:44,445,659...44,591,059

G

clock circadian regulator

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of CLOCK mRNA

NCBI chr 5:76,357,715...76,452,675
Ensembl chr 5:76,357,715...76,452,639

G

collagen, type XVIII, alpha 1

increases expression

caffeic acid phenethyl ester results in increased expression of COL18A1 protein

NCBI chr10:76,888,013...77,002,351
Ensembl chr10:76,888,012...77,002,382

G

cytochrome c oxidase subunit 4I2

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of COX4I2 mRNA

NCBI chr 2:152,596,093...152,606,957
Ensembl chr 2:152,596,093...152,606,957

G

cytochrome c oxidase subunit 6A2

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of COX6A2 mRNA

NCBI chr 7:127,804,607...127,805,538
Ensembl chr 7:127,804,607...127,805,559

G

cytochrome c oxidase subunit 7A2

multiple interactions

caffeic acid phenethyl ester inhibits the reaction [Diethylnitrosamine results in increased expression of COX7A2 mRNA]

NCBI chr 9:79,662,523...79,667,135
Ensembl chr 9:79,662,643...79,667,160

G

collapsin response mediator protein 1

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of CRMP1 mRNA

NCBI chr 5:37,399,402...37,449,507
Ensembl chr 5:37,399,284...37,449,477

G

citrate synthase

multiple interactions

[caffeic acid phenethyl ester co-treated with Dietary Fats] results in increased activity of CS protein; [caffeic acid phenethyl ester co-treated with Dietary Fats] results in increased expression of CS mRNA; NR1H4 protein affects the reaction [[caffeic acid phenethyl ester co-treated with Dietary Fats] results in increased activity of CS protein]; NR1H4 protein affects the reaction [[caffeic acid phenethyl ester co-treated with Dietary Fats] results in increased expression of CS mRNA]

NCBI chr10:128,173,596...128,198,351
Ensembl chr10:128,173,603...128,198,348

G

c-src tyrosine kinase

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of CSK mRNA

NCBI chr 9:57,533,929...57,560,758
Ensembl chr 9:57,533,929...57,560,914

G

chondroitin sulfate proteoglycan 4

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of CSPG4 mRNA

NCBI chr 9:56,772,388...56,807,154
Ensembl chr 9:56,772,317...56,807,154

G

catenin beta 1

decreases expression

caffeic acid phenethyl ester results in decreased expression of CTNNB1 protein

NCBI chr 9:120,762,466...120,789,573
Ensembl chr 9:120,758,282...120,789,573

G

cathepsin K

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of CTSK mRNA

NCBI chr 3:95,406,521...95,416,698
Ensembl chr 3:95,406,567...95,416,673

G

cathepsin M

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in increased expression of CTSM mRNA

NCBI chr13:61,683,553...61,689,697
Ensembl chr13:61,683,557...61,689,653

G

C-X-C motif chemokine ligand 15

multiple interactions

caffeic acid phenethyl ester inhibits the reaction [arsenite results in decreased expression of CXCL8 mRNA]

NCBI chr 5:90,942,393...90,950,926
Ensembl chr 5:90,942,393...90,950,926

G

C-X-C motif chemokine receptor 3

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of CXCR3 mRNA

NCBI chr X:100,775,141...100,777,753
Ensembl chr X:100,775,141...100,777,875

G

cytochrome b5 type A (microsomal)

multiple interactions

caffeic acid phenethyl ester inhibits the reaction [Diethylnitrosamine results in decreased expression of CYB5A mRNA]

NCBI chr18:84,869,463...84,897,996
Ensembl chr18:84,856,829...84,897,996

G

cytochrome b-245, alpha polypeptide

multiple interactions

caffeic acid phenethyl ester inhibits the reaction [Diethylnitrosamine results in increased expression of CYBA mRNA]

NCBI chr 8:123,151,510...123,159,679
Ensembl chr 8:123,151,515...123,159,669

G

cytochrome c, somatic

multiple interactions

caffeic acid phenethyl ester inhibits the reaction [Calcium results in increased secretion of CYCS protein]

NCBI chr 6:50,539,543...50,543,549
Ensembl chr 6:50,539,543...50,543,518

G

cytochrome P450, family 1, subfamily a, polypeptide 2

multiple interactions
decreases expression

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of CYP1A2 mRNA
caffeic acid phenethyl ester results in decreased expression of CYP1A2 protein

PMID:20360939 PMID:22291063

NCBI chr 9:57,584,220...57,590,938
Ensembl chr 9:57,584,220...57,590,986

G

cytochrome P450, family 2, subfamily b, polypeptide 13

decreases expression

caffeic acid phenethyl ester results in decreased expression of CYP2B2 protein

NCBI chr 7:25,760,813...25,795,622
Ensembl chr 7:25,760,922...25,795,622

G

cytochrome P450, family 2, subfamily e, polypeptide 1

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of CYP2E1 mRNA
caffeic acid phenethyl ester inhibits the reaction [CYP2E1 protein results in increased hydroxylation of aniline]

PMID:18436364 PMID:20360939

NCBI chr 7:140,343,732...140,354,903
Ensembl chr 7:140,343,652...140,354,900

G

cytohesin 2

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in increased expression of CYTH2 mRNA

NCBI chr 7:45,456,058...45,463,857
Ensembl chr 7:45,456,061...45,464,005

G

drebrin 1

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of DBN1 mRNA

NCBI chr13:55,621,241...55,635,874
Ensembl chr13:55,621,242...55,635,924

G

DNA-damage inducible transcript 3

multiple interactions

[caffeic acid phenethyl ester co-treated with Dietary Fats] results in decreased expression of DDIT3 mRNA; GW 4064 inhibits the reaction [[caffeic acid phenethyl ester co-treated with Dietary Fats] results in decreased expression of DDIT3 mRNA]; NR1H4 protein affects the reaction [[caffeic acid phenethyl ester co-treated with Dietary Fats] results in decreased expression of DDIT3 mRNA]

NCBI chr10:127,126,662...127,132,160
Ensembl chr10:127,126,643...127,132,157
Ensembl chr10:127,126,643...127,132,157

G

DEAF1, transcription factor

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in increased expression of DEAF1 mRNA

NCBI chr 7:140,877,089...140,918,758
Ensembl chr 7:140,877,093...140,907,603

G

delta 4-desaturase, sphingolipid 1

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of DEGS1 mRNA

NCBI chr 1:182,103,529...182,110,366
Ensembl chr 1:182,103,337...182,110,369

G

delta 4-desaturase, sphingolipid 2

multiple interactions

[caffeic acid phenethyl ester co-treated with Dietary Fats] results in decreased expression of DEGS2 mRNA; GW 4064 inhibits the reaction [[caffeic acid phenethyl ester co-treated with Dietary Fats] results in decreased expression of DEGS2 mRNA]; NR1H4 protein affects the reaction [[caffeic acid phenethyl ester co-treated with Dietary Fats] results in decreased expression of DEGS2 mRNA]

NCBI chr12:108,653,051...108,668,561
Ensembl chr12:108,644,970...108,668,570

G

diacylglycerol kinase, beta

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of DGKB mRNA

NCBI chr12:37,930,169...38,684,238
Ensembl chr12:37,867,725...38,684,238

G

dihydrofolate reductase

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of DHFR mRNA

NCBI chr13:92,491,291...92,525,561
Ensembl chr13:92,491,234...92,525,561

G

disrupted in schizophrenia 1

multiple interactions

caffeic acid phenethyl ester inhibits the reaction [Diethylnitrosamine results in increased expression of DISC1 mRNA]

NCBI chr 8:125,773,928...125,991,882
Ensembl chr 8:125,780,934...125,988,597

G

doublesex and mab-3 related transcription factor 1

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of DMRT1 mRNA

NCBI chr19:25,483,070...25,581,692
Ensembl chr19:25,482,982...25,581,693

G

dynein, axonemal, heavy chain 10

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of DNAH10 mRNA

NCBI chr 5:124,802,149...124,911,372
Ensembl chr 5:124,802,149...124,911,372

G

dynein, axonemal, heavy chain 5

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of DNAH5 mRNA

NCBI chr15:28,155,000...28,472,191
Ensembl chr15:28,203,898...28,472,198

G

dihydropyrimidinase

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of DPYS mRNA

NCBI chr15:39,631,881...39,720,866
Ensembl chr15:39,631,883...39,720,866

G

dual specificity phosphatase 6

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in increased expression of DUSP6 mRNA

NCBI chr10:99,098,676...99,103,351
Ensembl chr10:99,099,093...99,103,351

G

E2F transcription factor 6

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of E2F6 mRNA

NCBI chr12:16,860,932...16,876,753
Ensembl chr12:16,860,964...16,889,743

G

enoyl Coenzyme A hydratase, short chain, 1, mitochondrial

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of ECHS1 mRNA

NCBI chr 7:139,685,623...139,696,334
Ensembl chr 7:139,685,623...139,696,389

G

endothelin 1

multiple interactions

caffeic acid phenethyl ester inhibits the reaction [Oxygen deficiency results in increased expression of EDN1 mRNA]; caffeic acid phenethyl ester inhibits the reaction [Oxygen deficiency results in increased expression of EDN1 protein]

NCBI chr13:42,454,952...42,461,466
Ensembl chr13:42,454,952...42,461,466

G

E26 avian leukemia oncogene 1, 5' domain

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of ETS1 mRNA

NCBI chr 9:32,547,501...32,669,116
Ensembl chr 9:32,547,517...32,669,116

G

fatty acid binding protein 7, brain

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of FABP7 mRNA

NCBI chr10:57,661,019...57,664,546
Ensembl chr10:57,660,977...57,664,546

G

Fas cell surface death receptor

multiple interactions

caffeic acid phenethyl ester inhibits the reaction [Carbon Tetrachloride results in increased expression of FAS protein]

NCBI chr19:34,267,926...34,305,175
Ensembl chr19:34,268,066...34,305,172

G

Fas ligand

multiple interactions

caffeic acid phenethyl ester inhibits the reaction [Carbon Tetrachloride results in increased expression of FASL protein]

NCBI chr 1:161,608,260...161,616,064
Ensembl chr 1:161,608,258...161,616,064

G

fibroblast growth factor 15

multiple interactions

[caffeic acid phenethyl ester co-treated with Dietary Fats] results in decreased expression of FGF15 mRNA; GW 4064 inhibits the reaction [[caffeic acid phenethyl ester co-treated with Dietary Fats] results in decreased expression of FGF15 mRNA]

NCBI chr 7:144,450,269...144,454,690
Ensembl chr 7:144,450,268...144,454,690

G

fibroblast growth factor 7

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of FGF7 mRNA

NCBI chr 2:125,876,578...125,933,105
Ensembl chr 2:125,876,578...125,933,105

G

fibrinogen gamma chain

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in increased expression of FGG mRNA

NCBI chr 3:82,915,031...82,922,363
Ensembl chr 3:82,915,031...82,922,356

G

flavin containing monooxygenase 2

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of FMO2 mRNA

NCBI chr 1:162,701,886...162,726,327
Ensembl chr 1:162,701,886...162,726,295

G

forkhead box C2

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of FOXC2 mRNA

NCBI chr 8:121,842,910...121,845,634
Ensembl chr 8:121,842,910...121,845,634

G

forkhead box D1

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of FOXD1 mRNA

NCBI chr13:98,490,753...98,493,213
Ensembl chr13:98,490,750...98,495,813

G

FERM domain containing 6

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of FRMD6 mRNA

NCBI chr12:70,872,235...70,949,009
Ensembl chr12:70,872,288...70,949,008

G

ferritin light polypeptide 1

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of FTL mRNA

NCBI chr 7:45,107,368...45,109,310
Ensembl chr 7:45,107,368...45,109,308

G

fucosyltransferase 2

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of FUT2 mRNA

NCBI chr 7:45,298,015...45,315,818
Ensembl chr 7:45,298,015...45,315,818

G

growth arrest specific 6

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of GAS6 mRNA

NCBI chr 8:13,515,374...13,544,535
Ensembl chr 8:13,515,374...13,544,490

G

vitamin D binding protein

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of GC mRNA

NCBI chr 5:89,565,370...89,605,757
Ensembl chr 5:89,565,381...89,605,757

G

GTP cyclohydrolase 1

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in increased expression of GCH1 mRNA

NCBI chr14:47,391,352...47,426,870
Ensembl chr14:47,391,352...47,426,870

G

glutamate-cysteine ligase, catalytic subunit

multiple interactions

caffeic acid phenethyl ester inhibits the reaction [Bleomycin results in decreased expression of GCLC protein]

NCBI chr 9:77,661,817...77,701,771
Ensembl chr 9:77,661,817...77,701,767

G

glial cell line derived neurotrophic factor

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of GDNF mRNA

NCBI chr15:7,839,529...7,867,061
Ensembl chr15:7,840,327...7,867,056

G

glial fibrillary acidic protein

multiple interactions
increases expression

NGFR protein affects the susceptibility to [caffeic acid phenethyl ester results in increased expression of GFAP protein]

NCBI chr11:102,778,162...102,791,368
Ensembl chr11:102,778,162...102,791,738

G

growth factor, augmenter of liver regeneration

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of GFER mRNA

NCBI chr17:24,912,164...24,915,065
Ensembl chr17:24,912,161...24,915,130

G

glial cell line derived neurotrophic factor family receptor alpha 4

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of GFRA4 mRNA

NCBI chr 2:130,881,552...130,885,008
Ensembl chr 2:130,881,552...130,885,008

G

growth hormone receptor

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in increased expression of GHR mRNA

NCBI chr15:3,347,237...3,612,834
Ensembl chr15:3,347,242...3,612,974

G

gap junction protein, beta 1

multiple interactions

caffeic acid phenethyl ester inhibits the reaction [GJB1 protein results in decreased expression of IL1B mRNA]; caffeic acid phenethyl ester inhibits the reaction [GJB1 protein results in decreased expression of IL1B protein]

NCBI chr X:100,419,982...100,429,235
Ensembl chr X:100,419,984...100,429,235

G

gap junction protein, gamma 2

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of GJC2 mRNA

NCBI chr11:59,066,390...59,074,039
Ensembl chr11:59,066,394...59,074,039

G

glutaminase

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of GLS mRNA

NCBI chr 1:52,202,608...52,274,168
Ensembl chr 1:52,202,607...52,272,391

G

guanine nucleotide binding protein, alpha stimulating, olfactory type

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of GNAL mRNA

NCBI chr18:67,221,369...67,359,863
Ensembl chr18:67,221,287...67,359,863

G

golgin A2

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of GOLGA2 mRNA

NCBI chr 2:32,178,299...32,197,925
Ensembl chr 2:32,177,396...32,197,933

G

G protein-coupled receptor 19

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of GPR19 mRNA

NCBI chr 6:134,846,055...134,875,157
Ensembl chr 6:134,846,056...134,875,541

G

glutamate receptor, ionotropic, kainate 2 (beta 2)

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in increased expression of GRIK2 mRNA

NCBI chr10:48,969,776...49,666,523
Ensembl chr10:48,970,929...49,664,862

G

glutamate receptor, ionotropic, kainate 5 (gamma 2)

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of GRIK5 mRNA

NCBI chr 7:24,709,274...24,775,421
Ensembl chr 7:24,709,274...24,771,771

G

glutathione reductase

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in increased expression of GSR mRNA

NCBI chr 8:34,143,266...34,188,190
Ensembl chr 8:34,142,551...34,188,191

G

glutathione S-transferase kappa 1

multiple interactions

caffeic acid phenethyl ester inhibits the reaction [Diethylnitrosamine results in increased expression of GSTK1 mRNA]

NCBI chr 6:42,222,869...42,227,375
Ensembl chr 6:42,222,869...42,227,381

G

glutathione S-transferase, pi 1

decreases expression

caffeic acid phenethyl ester results in decreased expression of GSTP1 protein

NCBI chr19:4,085,411...4,087,912
Ensembl chr19:4,085,407...4,087,985

G

glycogenin 1

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of GYG1 mRNA

NCBI chr 3:20,176,248...20,209,228
Ensembl chr 3:20,176,248...20,209,481

G

H2A clustered histone 1

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of H2AC1 mRNA

NCBI chr13:24,118,420...24,118,896
Ensembl chr13:24,118,445...24,118,834

G

hepcidin antimicrobial peptide

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in increased expression of HAMP mRNA

NCBI chr 7:30,641,793...30,643,454
Ensembl chr 7:30,641,793...30,643,457

G

heparin binding growth factor

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in increased expression of HDGF mRNA

NCBI chr 3:87,813,844...87,823,439
Ensembl chr 3:87,813,628...87,823,439

G

3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2

multiple interactions

caffeic acid phenethyl ester inhibits the reaction [Diethylnitrosamine results in decreased expression of HMGCS2 mRNA]

NCBI chr 3:98,187,747...98,218,054
Ensembl chr 3:98,187,751...98,218,054

G

heme oxygenase 1

increases expression
multiple interactions

caffeic acid phenethyl ester results in increased expression of HMOX1 protein
caffeic acid phenethyl ester inhibits the reaction [Fructose results in increased expression of HMOX1 protein]; caffeic acid phenethyl ester inhibits the reaction [Streptozocin results in increased expression of HMOX1 protein]
caffeic acid phenethyl ester analog results in increased expression of HMOX1 mRNA; caffeic acid phenethyl ester analog results in increased expression of HMOX1 protein; caffeic acid phenethyl ester results in increased expression of HMOX1 mRNA; caffeic acid phenethyl ester results in increased expression of HMOX1 protein

PMID:20226179 PMID:20950636 PMID:21472898 PMID:23942037 PMID:24508943

NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217

G

heterogeneous nuclear ribonucleoprotein R

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of HNRNPR mRNA

NCBI chr 4:136,038,230...136,086,758
Ensembl chr 4:136,038,253...136,086,758

G

hippocalcin-like 4

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of HPCAL4 mRNA

NCBI chr 4:123,077,297...123,088,492
Ensembl chr 4:123,077,020...123,088,494

G

heat shock protein 2

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of HSPA2 mRNA

NCBI chr12:76,450,688...76,453,712
Ensembl chr12:76,450,950...76,453,712

G

heat shock protein 5

multiple interactions

[caffeic acid phenethyl ester co-treated with Dietary Fats] results in decreased expression of HSPA5 mRNA; GW 4064 inhibits the reaction [[caffeic acid phenethyl ester co-treated with Dietary Fats] results in decreased expression of HSPA5 mRNA]; NR1H4 protein affects the reaction [[caffeic acid phenethyl ester co-treated with Dietary Fats] results in decreased expression of HSPA5 mRNA]

NCBI chr 2:34,662,102...34,666,541
Ensembl chr 2:34,661,982...34,667,559

G

heat shock protein 1

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of HSPB1 mRNA

NCBI chr 5:135,916,773...135,918,417
Ensembl chr 5:135,916,773...135,918,417

G

heat shock protein 2

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of HSPB2 mRNA

NCBI chr 9:50,662,372...50,663,654
Ensembl chr 9:50,662,378...50,663,654

G

isocitrate dehydrogenase 3 (NAD+) alpha

multiple interactions

[caffeic acid phenethyl ester co-treated with Dietary Fats] results in increased expression of IDH3A mRNA; NR1H4 protein affects the reaction [[caffeic acid phenethyl ester co-treated with Dietary Fats] results in increased expression of IDH3A mRNA]

NCBI chr 9:54,493,795...54,511,946
Ensembl chr 9:54,493,618...54,511,945

G

isocitrate dehydrogenase 3 (NAD+) beta

multiple interactions

[caffeic acid phenethyl ester co-treated with Dietary Fats] results in increased expression of IDH3B mRNA; NR1H4 protein affects the reaction [[caffeic acid phenethyl ester co-treated with Dietary Fats] results in increased expression of IDH3B mRNA]

NCBI chr 2:130,121,229...130,126,371
Ensembl chr 2:130,121,229...130,126,467

G

isocitrate dehydrogenase 3 (NAD+), gamma

multiple interactions

[caffeic acid phenethyl ester co-treated with Dietary Fats] results in increased expression of IDH3G mRNA; NR1H4 protein affects the reaction [[caffeic acid phenethyl ester co-treated with Dietary Fats] results in increased expression of IDH3G mRNA]

NCBI chr X:72,822,569...72,830,471
Ensembl chr X:72,822,569...72,830,503

G

indoleamine 2,3-dioxygenase 1

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of IDO1 mRNA

NCBI chr 8:25,074,148...25,086,987
Ensembl chr 8:25,074,152...25,087,025

G

interferon gamma

multiple interactions

[Benzo(a)pyrene co-treated with caffeic acid phenethyl ester] results in decreased expression of IFNG protein; caffeic acid phenethyl ester inhibits the reaction [IFNG protein promotes the reaction [decitabine results in increased expression of PLA2G2A protein]]

PMID:18953428 PMID:24289642

NCBI chr10:118,276,951...118,281,799
Ensembl chr10:118,276,951...118,281,797

G

immunoglobulin (CD79A) binding protein 1

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of IGBP1 mRNA

NCBI chr X:99,537,897...99,559,731
Ensembl chr X:99,537,897...99,559,731

G

interleukin 12b

multiple interactions

caffeic acid phenethyl ester inhibits the reaction [AIMP1 protein results in increased expression of IL12B mRNA]

NCBI chr11:44,290,890...44,305,504
Ensembl chr11:44,290,890...44,304,860

G

interleukin 18

multiple interactions

caffeic acid phenethyl ester inhibits the reaction [arsenite results in decreased expression of IL18 mRNA]

NCBI chr 9:50,466,000...50,493,141
Ensembl chr 9:50,466,127...50,493,140

G

interleukin 1 alpha

multiple interactions

caffeic acid phenethyl ester inhibits the reaction [arsenite results in decreased expression of IL1A mRNA]

NCBI chr 2:129,141,530...129,151,892
Ensembl chr 2:129,141,530...129,151,892

G

interleukin 1 beta

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of IL1B mRNA; caffeic acid phenethyl ester inhibits the reaction [GJB1 protein results in decreased expression of IL1B mRNA]; caffeic acid phenethyl ester inhibits the reaction [GJB1 protein results in decreased expression of IL1B protein]
caffeic acid phenethyl ester inhibits the reaction [Cadmium Chloride results in increased expression of IL1B protein]

PMID:15350541 PMID:20360939 PMID:34743973

NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059

G

interleukin 2

multiple interactions

caffeic acid phenethyl ester inhibits the reaction [arsenite results in decreased expression of IL2 mRNA]

NCBI chr 3:37,174,862...37,180,103
Ensembl chr 3:37,174,672...37,180,108

G

interleukin 6

multiple interactions

caffeic acid phenethyl ester inhibits the reaction [Cadmium Chloride results in increased expression of IL6 protein]

NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979

G

insulin I

multiple interactions

[[NR1H4 protein co-treated with Dietary Fats] results in increased susceptibility to caffeic acid phenethyl ester] which results in decreased expression of INS1 protein

NCBI chr19:52,252,735...52,253,453
Ensembl chr19:52,252,735...52,253,914

G

insulin receptor-related receptor

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in increased expression of INSRR mRNA

NCBI chr 3:87,704,215...87,723,408
Ensembl chr 3:87,704,258...87,723,408

G

inositol hexaphosphate kinase 2

multiple interactions

caffeic acid phenethyl ester inhibits the reaction [Diethylnitrosamine results in increased expression of IP6K2 mRNA]

NCBI chr 9:108,660,928...108,683,532
Ensembl chr 9:108,660,995...108,683,536

G

insulin receptor substrate 1

decreases expression

caffeic acid phenethyl ester results in decreased expression of IRS1 mRNA

NCBI chr 1:82,210,826...82,269,160
Ensembl chr 1:82,210,822...82,269,137

G

integrin alpha M

increases expression
multiple interactions

caffeic acid phenethyl ester results in increased expression of ITGAM protein
caffeic acid phenethyl ester promotes the reaction [Tretinoin results in increased expression of ITGAM protein]

NCBI chr 7:127,661,812...127,717,663
Ensembl chr 7:127,661,812...127,717,663

G

inositol 1,4,5-trisphosphate receptor 1

multiple interactions

[caffeic acid phenethyl ester co-treated with Dietary Fats] results in decreased expression of ITPR1 mRNA; GW 4064 inhibits the reaction [[caffeic acid phenethyl ester co-treated with Dietary Fats] results in decreased expression of ITPR1 mRNA]; NR1H4 protein affects the reaction [[caffeic acid phenethyl ester co-treated with Dietary Fats] results in decreased expression of ITPR1 mRNA]

NCBI chr 6:108,190,044...108,528,077
Ensembl chr 6:108,190,057...108,528,070

G

inositol 1,4,5-triphosphate receptor 2

multiple interactions

[caffeic acid phenethyl ester co-treated with Dietary Fats] results in decreased expression of ITPR2 mRNA; NR1H4 protein affects the reaction [[caffeic acid phenethyl ester co-treated with Dietary Fats] results in decreased expression of ITPR2 mRNA]

NCBI chr 6:146,009,797...146,403,757
Ensembl chr 6:146,009,797...146,403,721

G

jun proto-oncogene

multiple interactions

caffeic acid phenethyl ester inhibits the reaction [arsenite results in increased expression of JUN mRNA]

NCBI chr 4:94,937,273...94,940,459
Ensembl chr 4:94,937,271...94,940,459

G

kalirin, RhoGEF kinase

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of KALRN mRNA

NCBI chr16:33,789,443...34,393,647
Ensembl chr16:33,789,443...34,393,902

G

potassium voltage-gated channel, subfamily G, member 3

multiple interactions

caffeic acid phenethyl ester inhibits the reaction [Diethylnitrosamine results in increased expression of KCNG3 mRNA]

NCBI chr17:83,881,452...83,939,595
Ensembl chr17:83,893,386...83,939,324

G

potassium voltage-gated channel, subfamily H (eag-related), member 5

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of KCNH5 mRNA

NCBI chr12:74,943,991...75,224,625
Ensembl chr12:74,943,994...75,224,106

G

potassium inwardly-rectifying channel, subfamily J, member 2

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in increased expression of KCNJ2 mRNA

NCBI chr11:110,956,990...110,967,651
Ensembl chr11:110,956,990...110,967,647

G

potassium large conductance calcium-activated channel, subfamily M, beta member 2

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of KCNMB2 mRNA

NCBI chr 3:31,956,021...32,254,329
Ensembl chr 3:31,956,656...32,254,329

G

potassium voltage-gated channel, subfamily Q, member 2

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of KCNQ2 mRNA

NCBI chr 2:180,717,372...180,777,368
Ensembl chr 2:180,717,372...180,777,093

G

potassium channel, subfamily T, member 2

decreases expression

caffeic acid phenethyl ester results in decreased expression of KCNT2 mRNA

NCBI chr 1:140,173,373...140,541,783
Ensembl chr 1:140,173,896...140,539,805

G

kinesin family member 6

multiple interactions

caffeic acid phenethyl ester inhibits the reaction [Diethylnitrosamine results in increased expression of KIF6 mRNA]

NCBI chr17:49,922,121...50,216,875
Ensembl chr17:49,922,164...50,216,875

G

kelch-like 17

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of KLHL17 mRNA

NCBI chr 4:156,313,501...156,319,314
Ensembl chr 4:156,313,792...156,319,314

G

lactalbumin, alpha

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of LALBA mRNA

NCBI chr15:98,378,281...98,380,827
Ensembl chr15:98,378,281...98,380,602

G

leptin

decreases expression

caffeic acid phenethyl ester results in decreased expression of LEP mRNA; caffeic acid phenethyl ester results in decreased expression of LEP protein

NCBI chr 6:29,060,220...29,073,875
Ensembl chr 6:29,060,219...29,073,876

G

leptin receptor overlapping transcript

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of LEPROT mRNA

NCBI chr 4:101,504,922...101,516,561
Ensembl chr 4:101,504,915...101,516,561

G

leucine-rich repeat LGI family, member 1

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of LGI1 mRNA

NCBI chr19:38,253,135...38,297,387
Ensembl chr19:38,252,984...38,300,662

G

lamin A

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of LMNA mRNA

NCBI chr 3:88,388,455...88,413,842
Ensembl chr 3:88,387,454...88,417,263

G

leucine rich repeat containing 15

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of LRRC15 mRNA

NCBI chr16:30,088,120...30,102,072
Ensembl chr16:30,088,120...30,102,074

G

mitogen-activated protein kinase 1

affects phosphorylation

caffeic acid phenethyl ester analog affects the phosphorylation of MAPK1 protein

NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317

G

mitogen-activated protein kinase 14

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of MAPK14 mRNA

NCBI chr17:28,910,316...28,967,379
Ensembl chr17:28,910,303...28,967,380

G

mitogen-activated protein kinase 3

affects phosphorylation

caffeic acid phenethyl ester analog affects the phosphorylation of MAPK3 protein

NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991

G

malic enzyme 1, NADP(+)-dependent, cytosolic

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of ME1 mRNA

NCBI chr 9:86,463,416...86,577,967
Ensembl chr 9:86,463,424...86,578,006

G

mitofusin 2

multiple interactions

[caffeic acid phenethyl ester co-treated with Dietary Fats] results in decreased expression of MFN2 mRNA; GW 4064 inhibits the reaction [[caffeic acid phenethyl ester co-treated with Dietary Fats] results in decreased expression of MFN2 mRNA]

NCBI chr 4:147,958,043...147,989,527
Ensembl chr 4:147,958,056...147,989,161

G

microRNA 182

multiple interactions

caffeic acid phenethyl ester inhibits the reaction [Cadmium Chloride results in decreased expression of MIR182 mRNA]

NCBI chr 6:30,165,917...30,165,991
Ensembl chr 6:30,165,917...30,165,991

G

matrix metallopeptidase 2

decreases activity
multiple interactions

caffeic acid phenethyl ester results in decreased activity of MMP2 protein
NGFR protein affects the susceptibility to [caffeic acid phenethyl ester results in decreased activity of MMP2 protein]

NCBI chr 8:93,553,920...93,580,049
Ensembl chr 8:93,553,919...93,580,048

G

matrix metallopeptidase 3

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in increased expression of MMP3 mRNA
caffeic acid phenethyl ester inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of MMP3 protein]

PMID:20360939 PMID:34791780

NCBI chr 9:7,445,845...7,455,975
Ensembl chr 9:7,445,822...7,455,975

G

matrix metallopeptidase 9

decreases expression
decreases activity
multiple interactions

caffeic acid phenethyl ester results in decreased expression of MMP9 protein
caffeic acid phenethyl ester results in decreased activity of MMP9 protein
NGFR protein affects the susceptibility to [caffeic acid phenethyl ester results in decreased activity of MMP9 protein]

PMID:20433813 PMID:20836997

NCBI chr 2:164,782,246...164,797,770
Ensembl chr 2:164,782,700...164,797,770

G

myeloperoxidase

multiple interactions

caffeic acid phenethyl ester inhibits the reaction [Doxorubicin results in increased activity of MPO protein]; caffeic acid phenethyl ester inhibits the reaction [Isoproterenol results in increased activity of MPO protein]; caffeic acid phenethyl ester inhibits the reaction [Lipopolysaccharides results in increased activity of MPO protein]

PMID:15369732 PMID:20693123 PMID:21472898

NCBI chr11:87,684,610...87,695,238
Ensembl chr11:87,684,407...87,695,239

G

myosin phosphatase Rho interacting protein

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of MPRIP mRNA

NCBI chr11:59,552,973...59,671,686
Ensembl chr11:59,552,131...59,671,686

G

msh homeobox 2

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of MSX2 mRNA

NCBI chr13:53,620,917...53,626,816
Ensembl chr13:53,620,920...53,627,110

G

mitochondrial transcription termination factor 1a

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of MTERF1 mRNA

NCBI chr 5:3,914,576...3,943,933
Ensembl chr 5:3,940,581...3,943,933

G

mitochondrial tumor suppressor 1

multiple interactions

caffeic acid phenethyl ester inhibits the reaction [Diethylnitrosamine results in increased expression of MTUS1 mRNA]

NCBI chr 8:41,443,949...41,587,318
Ensembl chr 8:41,443,951...41,586,763

G

mucin 1, transmembrane

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of MUC1 mRNA

NCBI chr 3:89,136,363...89,140,688
Ensembl chr 3:89,136,364...89,140,688

G

murinoglobulin 2

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of PZP mRNA

NCBI chr 6:121,983,688...122,062,927
Ensembl chr 6:121,983,720...122,062,924

G

MAX interactor 1, dimerization protein

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of MXI1 mRNA

NCBI chr19:53,298,509...53,361,724
Ensembl chr19:53,298,949...53,364,241

G

myosin IXa

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in increased expression of MYO9A mRNA

NCBI chr 9:59,658,128...59,836,149
Ensembl chr 9:59,658,179...59,836,149

G

N-acetyltransferase 8B, pseudogene

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of NAT8B mRNA

NCBI chr 6:85,909,539...85,910,364
Ensembl chr 6:85,909,663...85,910,361

G

neural cell adhesion molecule 1

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of NCAM1 mRNA

NCBI chr 9:49,413,434...49,710,909
Ensembl chr 9:49,413,436...49,710,225

G

neogenin

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of NEO1 mRNA

NCBI chr 9:58,781,962...58,943,926
Ensembl chr 9:58,781,970...58,943,724

G

nuclear factor, erythroid derived 2, like 2

multiple interactions

caffeic acid phenethyl ester promotes the reaction [Nitrogen Mustard Compounds results in increased expression of NFE2L2 protein]
caffeic acid phenethyl ester inhibits the reaction [Bleomycin results in decreased expression of NFE2L2 protein]

PMID:17204746 PMID:23570914

NCBI chr 2:75,505,860...75,535,007
Ensembl chr 2:75,505,857...75,534,985

G

nuclear factor I/A

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of NFIA mRNA

NCBI chr 4:97,469,534...98,007,113
Ensembl chr 4:97,660,971...98,007,111

G

nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105

multiple interactions

caffeic acid phenethyl ester inhibits the reaction [Zymosan results in increased activity of [NFKB1 protein binds to RELA protein]]
caffeic acid phenethyl ester results in decreased activity of [NFKB1 protein binds to RELA protein]

PMID:11259437 PMID:16052512

NCBI chr 3:135,290,416...135,397,422
Ensembl chr 3:135,290,416...135,397,308

G

nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100

multiple interactions

caffeic acid phenethyl ester inhibits the reaction [sodium arsenite results in increased expression of NFKB2 protein]

NCBI chr19:46,285,478...46,300,839
Ensembl chr19:46,292,759...46,300,824

G

nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha

decreases phosphorylation

caffeic acid phenethyl ester results in decreased phosphorylation of NFKBIA protein

NCBI chr12:55,536,194...55,539,432
Ensembl chr12:55,536,195...55,539,432

G

nuclear transcription factor-Y alpha

multiple interactions

caffeic acid phenethyl ester inhibits the reaction [Diethylnitrosamine results in increased expression of NFYA mRNA]

NCBI chr17:48,693,917...48,716,782
Ensembl chr17:48,693,913...48,716,934

G

nerve growth factor

increases expression

caffeic acid phenethyl ester results in increased expression of NGF protein

NCBI chr 3:102,377,235...102,428,329
Ensembl chr 3:102,377,235...102,428,329

G

nerve growth factor receptor (TNFR superfamily, member 16)

increases expression
affects response to substance
multiple interactions

caffeic acid phenethyl ester results in increased expression of NGFR protein
NGFR protein affects the susceptibility to caffeic acid phenethyl ester
NGFR protein affects the susceptibility to [caffeic acid phenethyl ester results in decreased activity of MMP2 protein]; NGFR protein affects the susceptibility to [caffeic acid phenethyl ester results in decreased activity of MMP9 protein]; NGFR protein affects the susceptibility to [caffeic acid phenethyl ester results in increased expression of GFAP protein]; NGFR protein affects the susceptibility to [caffeic acid phenethyl ester results in increased expression of RHOB protein]; NGFR protein affects the susceptibility to [caffeic acid phenethyl ester results in increased expression of S100B protein]

NCBI chr11:95,459,644...95,478,524
Ensembl chr11:95,459,644...95,478,561

G

noggin

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of NOG mRNA

NCBI chr11:89,191,464...89,193,385
Ensembl chr11:89,191,464...89,193,158

G

nitric oxide synthase 2, inducible

decreases expression

caffeic acid phenethyl ester results in decreased expression of NOS2 protein

NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080

G

notch 2

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of NOTCH2 mRNA

NCBI chr 3:97,920,854...98,057,683
Ensembl chr 3:97,920,843...98,057,677

G

NADPH oxidase 4

multiple interactions

caffeic acid phenethyl ester inhibits the reaction [Particulate Matter results in increased expression of NOX4 mRNA]; caffeic acid phenethyl ester inhibits the reaction [Particulate Matter results in increased expression of NOX4 protein]; caffeic acid phenethyl ester inhibits the reaction [Vehicle Emissions results in increased expression of NOX4 mRNA]; caffeic acid phenethyl ester inhibits the reaction [Vehicle Emissions results in increased expression of NOX4 protein]

NCBI chr 7:86,893,638...87,047,918
Ensembl chr 7:86,895,304...87,047,918

G

nuclear receptor subfamily 0, group B, member 2

multiple interactions

[caffeic acid phenethyl ester co-treated with Dietary Fats] results in decreased expression of NR0B2 mRNA; GW 4064 inhibits the reaction [[caffeic acid phenethyl ester co-treated with Dietary Fats] results in decreased expression of NR0B2 mRNA]

NCBI chr 4:133,280,687...133,283,997
Ensembl chr 4:133,280,687...133,283,847

G

nuclear receptor subfamily 1, group H, member 4

multiple interactions

[[NR1H4 protein co-treated with Dietary Fats] results in increased susceptibility to caffeic acid phenethyl ester] which results in decreased expression of INS1 protein; [[NR1H4 protein co-treated with Dietary Fats] results in increased susceptibility to caffeic acid phenethyl ester] which results in increased abundance of Citric Acid; [[NR1H4 protein co-treated with Dietary Fats] results in increased susceptibility to caffeic acid phenethyl ester] which results in increased abundance of Fumarates; [[NR1H4 protein co-treated with Dietary Fats] results in increased susceptibility to caffeic acid phenethyl ester] which results in increased abundance of Ketoglutaric Acids; [[NR1H4 protein co-treated with Dietary Fats] results in increased susceptibility to caffeic acid phenethyl ester] which results in increased abundance of malic acid; [NR1H4 protein co-treated with Dietary Fats] results in increased susceptibility to caffeic acid phenethyl ester; NR1H4 protein affects the reaction [[caffeic acid phenethyl ester co-treated with Dietary Fats] results in decreased expression of CERS2 mRNA]; NR1H4 protein affects the reaction [[caffeic acid phenethyl ester co-treated with Dietary Fats] results in decreased expression of CERS4 mRNA]; NR1H4 protein affects the reaction [[caffeic acid phenethyl ester co-treated with Dietary Fats] results in decreased expression of DDIT3 mRNA]; NR1H4 protein affects the reaction [[caffeic acid phenethyl ester co-treated with Dietary Fats] results in decreased expression of DEGS2 mRNA]; NR1H4 protein affects the reaction [[caffeic acid phenethyl ester co-treated with Dietary Fats] results in decreased expression of HSPA5 mRNA]; NR1H4 protein affects the reaction [[caffeic acid phenethyl ester co-treated with Dietary Fats] results in decreased expression of ITPR1 mRNA]; NR1H4 protein affects the reaction [[caffeic acid phenethyl ester co-treated with Dietary Fats] results in decreased expression of ITPR2 mRNA]; NR1H4 protein affects the reaction [[caffeic acid phenethyl ester co-treated with Dietary Fats] results in decreased expression of PACS2 mRNA]; NR1H4 protein affects the reaction [[caffeic acid phenethyl ester co-treated with Dietary Fats] results in decreased expression of SMPD3 mRNA]; NR1H4 protein affects the reaction [[caffeic acid phenethyl ester co-treated with Dietary Fats] results in decreased expression of SMPD4 mRNA]; NR1H4 protein affects the reaction [[caffeic acid phenethyl ester co-treated with Dietary Fats] results in decreased expression of SPTLC2 mRNA]; NR1H4 protein affects the reaction [[caffeic acid phenethyl ester co-treated with Dietary Fats] results in decreased expression of VDAC1 mRNA]; NR1H4 protein affects the reaction [[caffeic acid phenethyl ester co-treated with Dietary Fats] results in increased activity of CS protein]; NR1H4 protein affects the reaction [[caffeic acid phenethyl ester co-treated with Dietary Fats] results in increased expression of CS mRNA]; NR1H4 protein affects the reaction [[caffeic acid phenethyl ester co-treated with Dietary Fats] results in increased expression of IDH3A mRNA]; NR1H4 protein affects the reaction [[caffeic acid phenethyl ester co-treated with Dietary Fats] results in increased expression of IDH3B mRNA]; NR1H4 protein affects the reaction [[caffeic acid phenethyl ester co-treated with Dietary Fats] results in increased expression of IDH3G mRNA]

NCBI chr10:89,290,096...89,369,484
Ensembl chr10:89,290,096...89,369,447

G

neurturin

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of NRTN mRNA

NCBI chr17:57,058,323...57,064,548
Ensembl chr17:57,058,325...57,064,530

G

nucleoporin 88

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in increased expression of NUP88 mRNA

NCBI chr11:70,833,884...70,860,799
Ensembl chr11:70,833,884...70,860,799

G

outer dense fiber of sperm tails 1

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of ODF1 mRNA

NCBI chr15:38,219,447...38,226,979
Ensembl chr15:38,219,447...38,226,979

G

oligodendrocyte transcription factor 1

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in increased expression of OLIG1 mRNA

NCBI chr16:91,066,657...91,068,827
Ensembl chr16:91,066,660...91,068,821

G

oxidized low density lipoprotein (lectin-like) receptor 1

multiple interactions

caffeic acid phenethyl ester inhibits the reaction [sodium arsenite results in increased expression of OLR1 protein]

NCBI chr 6:129,456,113...129,484,312
Ensembl chr 6:129,462,207...129,484,128

G

OPA1, mitochondrial dynamin like GTPase

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of OPA1 mRNA

NCBI chr16:29,398,099...29,481,924
Ensembl chr16:29,398,152...29,473,702

G

phosphofurin acidic cluster sorting protein 2

multiple interactions

[caffeic acid phenethyl ester co-treated with Dietary Fats] results in decreased expression of PACS2 mRNA; GW 4064 inhibits the reaction [[caffeic acid phenethyl ester co-treated with Dietary Fats] results in decreased expression of PACS2 mRNA]; NR1H4 protein affects the reaction [[caffeic acid phenethyl ester co-treated with Dietary Fats] results in decreased expression of PACS2 mRNA]

NCBI chr12:112,977,998...113,038,021
Ensembl chr12:112,978,128...113,038,021

G

par-3 family cell polarity regulator

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of PARD3 mRNA

NCBI chr 8:127,790,131...128,338,767
Ensembl chr 8:127,790,643...128,338,767

G

phosphoenolpyruvate carboxykinase 1, cytosolic

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of PCK1 mRNA

NCBI chr 2:172,994,866...173,001,067
Ensembl chr 2:172,994,841...173,001,066

G

proprotein convertase subtilisin/kexin type 1 inhibitor

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of PCSK1N mRNA

NCBI chr X:7,786,061...7,790,649
Ensembl chr X:7,786,061...7,790,649

G

proprotein convertase subtilisin/kexin type 2

multiple interactions

caffeic acid phenethyl ester inhibits the reaction [Diethylnitrosamine results in increased expression of PCSK2 mRNA]

NCBI chr 2:143,388,053...143,658,204
Ensembl chr 2:143,388,076...143,658,205

G

proprotein convertase subtilisin/kexin type 6

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in increased expression of PCSK6 mRNA

NCBI chr 7:65,511,884...65,700,134
Ensembl chr 7:65,511,482...65,700,134

G

pyruvate carboxylase

multiple interactions

[caffeic acid phenethyl ester co-treated with Dietary Fats] results in decreased activity of PC protein; GW 4064 inhibits the reaction [[caffeic acid phenethyl ester co-treated with Dietary Fats] results in decreased activity of PC protein]

NCBI chr19:4,560,500...4,671,780
Ensembl chr19:4,560,500...4,671,780

G

platelet derived growth factor receptor, beta polypeptide

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in increased expression of PDGFRB mRNA

NCBI chr18:61,178,194...61,218,139
Ensembl chr18:61,178,222...61,218,133

G

period circadian clock 3

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of PER3 mRNA

NCBI chr 4:151,081,475...151,129,167
Ensembl chr 4:151,088,109...151,129,122

G

phosphofructokinase, platelet

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of PFKP mRNA

NCBI chr13:6,629,910...6,699,096
Ensembl chr13:6,629,804...6,698,813

G

phosphorylase kinase, gamma 2 (testis)

multiple interactions

caffeic acid phenethyl ester inhibits the reaction [Diethylnitrosamine results in decreased expression of PHKG2 mRNA]

NCBI chr 7:127,169,252...127,182,479
Ensembl chr 7:127,172,512...127,182,479

G

protein inhibitor of activated STAT 2

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of PIAS2 mRNA

NCBI chr18:77,152,883...77,243,406
Ensembl chr18:77,152,904...77,241,496

G

phospholipase A2, group IIA (platelets, synovial fluid)

multiple interactions

caffeic acid phenethyl ester inhibits the reaction [IFNG protein promotes the reaction [decitabine results in increased expression of PLA2G2A protein]]

NCBI chr 4:138,559,168...138,562,500
Ensembl chr 4:138,559,171...138,562,497

G

phospholipase C, gamma 1

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of PLCG1 mRNA

NCBI chr 2:160,573,230...160,617,680
Ensembl chr 2:160,573,220...160,617,680

G

pleckstrin homology domain containing, family A member 5

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of PLEKHA5 mRNA

NCBI chr 6:140,369,358...140,542,836
Ensembl chr 6:140,369,780...140,542,836

G

polymerase (DNA directed), delta 1, catalytic subunit

multiple interactions

caffeic acid phenethyl ester inhibits the reaction [Diethylnitrosamine results in increased expression of POLD1 mRNA]

NCBI chr 7:44,182,168...44,198,239
Ensembl chr 7:44,182,170...44,198,273

G

polymerase (DNA directed), gamma

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of POLG mRNA

NCBI chr 7:79,095,979...79,117,659
Ensembl chr 7:79,095,979...79,116,110

G

peroxisome proliferator activated receptor gamma

decreases expression

caffeic acid phenethyl ester results in decreased expression of PPARG mRNA

NCBI chr 6:115,337,828...115,467,365
Ensembl chr 6:115,337,912...115,467,360

G

protein phosphatase 2, regulatory subunit B, alpha

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of PPP2R2A mRNA

NCBI chr14:67,251,505...67,309,920
Ensembl chr14:67,251,505...67,309,893

G

protein phosphatase 4, catalytic subunit

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of PPP4C mRNA

NCBI chr 7:126,385,038...126,391,729
Ensembl chr 7:126,385,038...126,391,668

G

prolyl endopeptidase

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of PREP mRNA

NCBI chr10:44,943,312...45,038,847
Ensembl chr10:44,943,299...45,043,294

G

protein kinase, cAMP dependent, catalytic, alpha

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of PRKACA mRNA

NCBI chr 8:84,699,607...84,723,073
Ensembl chr 8:84,699,622...84,723,072

G

protein kinase, cAMP dependent regulatory, type II alpha

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of PRKAR2A mRNA

NCBI chr 9:108,569,342...108,627,643
Ensembl chr 9:108,566,513...108,627,635

G

protein kinase C, epsilon

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of PRKCE mRNA

NCBI chr17:86,472,631...86,965,347
Ensembl chr17:86,475,213...86,965,347

G

prokineticin 2

multiple interactions

caffeic acid phenethyl ester inhibits the reaction [Diethylnitrosamine results in increased expression of PROK2 mRNA]

NCBI chr 6:99,687,833...99,703,368
Ensembl chr 6:99,688,260...99,703,353

G

prominin 1

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in increased expression of PROM1 mRNA

NCBI chr 5:44,150,963...44,260,850
Ensembl chr 5:44,150,962...44,259,374

G

serine protease 12 neurotrypsin (motopsin)

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of PRSS12 mRNA

NCBI chr 3:123,240,562...123,300,251
Ensembl chr 3:123,240,562...123,300,246

G

proteasome subunit alpha 7

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of PSMA7 mRNA

NCBI chr 2:179,678,160...179,684,257
Ensembl chr 2:179,678,167...179,684,226

G

PTK2 protein tyrosine kinase 2

decreases phosphorylation

caffeic acid phenethyl ester results in decreased phosphorylation of PTK2 protein

NCBI chr15:73,076,951...73,297,192
Ensembl chr15:73,076,951...73,295,129

G

protein tyrosine phosphatase, non-receptor type 1

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in increased expression of PTPN1 mRNA

NCBI chr 2:167,772,670...167,821,305
Ensembl chr 2:167,773,977...167,821,305

G

receptor (calcitonin) activity modifying protein 1

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of RAMP1 mRNA

NCBI chr 1:91,107,544...91,152,918
Ensembl chr 1:91,107,544...91,152,918

G

retinoic acid receptor, alpha

increases activity
multiple interactions
increases expression

caffeic acid phenethyl ester results in increased activity of RARA protein
[Tretinoin co-treated with caffeic acid phenethyl ester] results in increased expression of RARA mRNA; [Tretinoin co-treated with caffeic acid phenethyl ester] results in increased expression of RARA protein; caffeic acid phenethyl ester promotes the reaction [Tretinoin results in increased activity of RARA protein]
caffeic acid phenethyl ester results in increased expression of RARA mRNA; caffeic acid phenethyl ester results in increased expression of RARA protein

NCBI chr11:98,818,626...98,865,768
Ensembl chr11:98,818,644...98,865,768

G

RB transcriptional corepressor 1

decreases expression

caffeic acid phenethyl ester results in decreased expression of RB1 protein modified form

NCBI chr14:73,430,298...73,563,446
Ensembl chr14:73,421,113...73,563,262

G

regulator of calcineurin 1

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in increased expression of RCAN1 mRNA

NCBI chr16:92,188,839...92,263,057
Ensembl chr16:92,188,841...92,267,755

G

v-rel reticuloendotheliosis viral oncogene homolog A (avian)

multiple interactions

caffeic acid phenethyl ester inhibits the reaction [Paclitaxel results in increased activity of RELA protein]; caffeic acid phenethyl ester inhibits the reaction [TNF protein results in increased activity of RELA protein]; caffeic acid phenethyl ester results in decreased activity of [NFKB1 protein binds to RELA protein]
caffeic acid phenethyl ester inhibits the reaction [Zymosan results in increased activity of [NFKB1 protein binds to RELA protein]]

PMID:11259437 PMID:15291876 PMID:16052512 PMID:26562779

NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158

G

rad and gem related GTP binding protein 2

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of REM2 mRNA

NCBI chr14:54,713,676...54,717,889
Ensembl chr14:54,713,557...54,717,888

G

ret proto-oncogene

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of RET mRNA

NCBI chr 6:118,128,709...118,174,705
Ensembl chr 6:118,128,706...118,174,679

G

resistin

decreases expression

caffeic acid phenethyl ester results in decreased expression of RETN protein

NCBI chr 8:3,705,770...3,709,818
Ensembl chr 8:3,705,770...3,710,110

G

replication factor C (activator 1) 1

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of RFC1 mRNA

NCBI chr 5:65,419,195...65,492,988
Ensembl chr 5:65,419,193...65,493,013

G

regulator of G-protein signaling 6

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of RGS6 mRNA

NCBI chr12:82,663,325...83,208,835
Ensembl chr12:82,635,066...83,208,830

G

ras homolog family member B

multiple interactions
increases expression

NGFR protein affects the susceptibility to [caffeic acid phenethyl ester results in increased expression of RHOB protein]

NCBI chr12:8,547,661...8,550,009
Ensembl chr12:8,547,661...8,550,009

G

retinal pigment epithelium 65

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of RPE65 mRNA

NCBI chr 3:159,304,712...159,330,944
Ensembl chr 3:159,304,812...159,330,958

G

rabphilin 3A

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of RPH3A mRNA

NCBI chr 5:121,078,562...121,184,249
Ensembl chr 5:121,078,562...121,148,155

G

ribosomal protein L26

multiple interactions

caffeic acid phenethyl ester inhibits the reaction [Diethylnitrosamine results in increased expression of RPL26 mRNA]

NCBI chr11:68,792,392...68,795,360
Ensembl chr11:68,792,409...68,797,815

G

ribosomal protein S3A1

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of RPS3A mRNA

NCBI chr 3:86,045,247...86,049,975
Ensembl chr 3:86,045,247...86,050,009

G

ribosomal protein S6 kinase, polypeptide 2

multiple interactions

caffeic acid phenethyl ester inhibits the reaction [Mustard Compounds results in increased phosphorylation of RPS6KA2 protein]; caffeic acid phenethyl ester inhibits the reaction [Nitrogen Mustard Compounds results in increased phosphorylation of RPS6KA2 protein]

NCBI chr17:7,356,384...7,570,714
Ensembl chr17:7,437,514...7,570,714

G

ribosomal protein S9

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of RPS9 mRNA

NCBI chr 7:3,707,035...3,709,896
Ensembl chr 7:3,706,992...3,709,896

G

runt related transcription factor 2

multiple interactions

caffeic acid phenethyl ester inhibits the reaction [Dexamethasone results in decreased expression of RUNX2 protein]

NCBI chr17:44,806,873...45,125,518
Ensembl chr17:44,806,874...45,125,684

G

S100 protein, beta polypeptide, neural

increases expression
multiple interactions

caffeic acid phenethyl ester results in increased expression of S100B protein
NGFR protein affects the susceptibility to [caffeic acid phenethyl ester results in increased expression of S100B protein]

NCBI chr10:76,089,670...76,097,153
Ensembl chr10:76,089,687...76,096,993

G

S phase cyclin A-associated protein in the ER

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of SCAPER mRNA

NCBI chr 9:55,457,163...55,845,505
Ensembl chr 9:55,457,163...55,845,403

G

stearoyl-Coenzyme A desaturase 1

multiple interactions

caffeic acid phenethyl ester inhibits the reaction [Diethylnitrosamine results in decreased expression of SCD1 mRNA]

NCBI chr19:44,382,889...44,396,148
Ensembl chr19:44,382,894...44,396,318

G

sodium channel, nonvoltage-gated 1 gamma

multiple interactions

caffeic acid phenethyl ester inhibits the reaction [Diethylnitrosamine results in increased expression of SCNN1G mRNA]

NCBI chr 7:121,333,643...121,367,705
Ensembl chr 7:121,333,702...121,367,698

G

syndecan 4

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in increased expression of SDC4 mRNA

NCBI chr 2:164,266,167...164,285,512
Ensembl chr 2:164,266,167...164,285,807

G

serine dehydratase

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of SDS mRNA

NCBI chr 5:120,614,612...120,621,997
Ensembl chr 5:120,614,591...120,621,997

G

serine (or cysteine) peptidase inhibitor, clade B, member 2

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of SERPINB2 mRNA

NCBI chr 1:107,439,153...107,453,330
Ensembl chr 1:107,439,153...107,463,208

G

serine (or cysteine) peptidase inhibitor, clade B, member 5

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of SERPINB5 mRNA

NCBI chr 1:106,788,905...106,811,078
Ensembl chr 1:106,788,903...106,811,078

G

serine (or cysteine) peptidase inhibitor, clade F, member 1

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of SERPINF1 mRNA

NCBI chr11:75,300,855...75,313,449
Ensembl chr11:75,300,595...75,313,527

G

sirtuin 2

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of SIRT2 mRNA

NCBI chr 7:28,466,192...28,488,086
Ensembl chr 7:28,466,160...28,488,086

G

solute carrier family 12 (potassium/chloride transporters), member 8

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of SLC12A8 mRNA

NCBI chr16:33,337,440...33,484,508
Ensembl chr16:33,337,698...33,484,505

G

solute carrier family 14 (urea transporter), member 2

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of SLC14A2 mRNA

NCBI chr18:78,189,359...78,640,165
Ensembl chr18:78,189,363...78,640,157

G

solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 8

multiple interactions

caffeic acid phenethyl ester inhibits the reaction [Diethylnitrosamine results in decreased expression of SLC17A8 mRNA]

NCBI chr10:89,409,882...89,457,111
Ensembl chr10:89,409,882...89,457,115

G

solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of SLC1A1 mRNA

NCBI chr19:28,812,535...28,891,360
Ensembl chr19:28,812,449...28,891,360

G

solute carrier family 1 (neutral amino acid transporter), member 5

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of SLC1A5 mRNA

NCBI chr 7:16,515,259...16,532,199
Ensembl chr 7:16,515,265...16,532,199

G

solute carrier family 38, member 2

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of SLC38A2 mRNA

NCBI chr15:96,585,267...96,597,609
Ensembl chr15:96,585,273...96,597,611

G

solute carrier family 45, member 1

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of SLC45A1 mRNA

NCBI chr 4:150,713,853...150,736,614
Ensembl chr 4:150,713,029...150,736,631

G

solute carrier family 4 (anion exchanger), member 2

multiple interactions

caffeic acid phenethyl ester inhibits the reaction [Diethylnitrosamine results in decreased expression of SLC4A2 mRNA]

NCBI chr 5:24,628,834...24,645,945
Ensembl chr 5:24,628,835...24,645,948

G

solute carrier family 51, alpha subunit

multiple interactions

[caffeic acid phenethyl ester co-treated with Dietary Fats] results in decreased expression of SLC51A mRNA; GW 4064 inhibits the reaction [[caffeic acid phenethyl ester co-treated with Dietary Fats] results in decreased expression of SLC51A mRNA]

NCBI chr16:32,294,396...32,306,697
Ensembl chr16:32,293,322...32,306,697

G

solute carrier family 51, beta subunit

multiple interactions

[caffeic acid phenethyl ester co-treated with Dietary Fats] results in decreased expression of SLC51B mRNA; GW 4064 inhibits the reaction [[caffeic acid phenethyl ester co-treated with Dietary Fats] results in decreased expression of SLC51B mRNA]

NCBI chr 9:65,320,035...65,330,055
Ensembl chr 9:65,319,996...65,330,237

G

solute carrier family 6 (neurotransmitter transporter, glycine), member 9

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of SLC6A9 mRNA

NCBI chr 4:117,692,240...117,726,502
Ensembl chr 4:117,691,703...117,732,395

G

sphingomyelin phosphodiesterase 3, neutral

multiple interactions

[caffeic acid phenethyl ester co-treated with Dietary Fats] results in decreased expression of SMPD3 mRNA; GW 4064 inhibits the reaction [[caffeic acid phenethyl ester co-treated with Dietary Fats] results in decreased expression of SMPD3 mRNA]; NR1H4 protein affects the reaction [[caffeic acid phenethyl ester co-treated with Dietary Fats] results in decreased expression of SMPD3 mRNA]

NCBI chr 8:106,979,180...107,064,597
Ensembl chr 8:106,979,180...107,064,620

G

sphingomyelin phosphodiesterase 4

multiple interactions

[caffeic acid phenethyl ester co-treated with Dietary Fats] results in decreased expression of SMPD4 mRNA; GW 4064 inhibits the reaction [[caffeic acid phenethyl ester co-treated with Dietary Fats] results in decreased expression of SMPD4 mRNA]; NR1H4 protein affects the reaction [[caffeic acid phenethyl ester co-treated with Dietary Fats] results in decreased expression of SMPD4 mRNA]

NCBI chr16:17,437,218...17,462,694
Ensembl chr16:17,437,218...17,462,692

G

staphylococcal nuclease and tudor domain containing 1

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in increased expression of SND1 mRNA

NCBI chr 6:28,480,332...28,935,161
Ensembl chr 6:28,475,138...28,935,161

G

sterol O-acyltransferase 1

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of SOAT1 mRNA

NCBI chr 1:156,255,678...156,301,898
Ensembl chr 1:156,252,095...156,301,901

G

superoxide dismutase 1, soluble

multiple interactions

caffeic acid phenethyl ester inhibits the reaction [sodium arsenite results in decreased expression of SOD1 protein]

NCBI chr16:90,017,650...90,023,221
Ensembl chr16:90,017,642...90,023,217

G

SRY (sex determining region Y)-box 10

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of SOX10 mRNA

NCBI chr15:79,039,113...79,048,690
Ensembl chr15:79,039,108...79,049,440

G

sperm autoantigenic protein 17

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of SPA17 mRNA

NCBI chr 9:37,514,590...37,525,018
Ensembl chr 9:37,514,586...37,525,018

G

sphingosine kinase 1

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of SPHK1 mRNA

NCBI chr11:116,421,662...116,427,502
Ensembl chr11:116,421,751...116,427,501

G

serine palmitoyltransferase, long chain base subunit 2

multiple interactions

[caffeic acid phenethyl ester co-treated with Dietary Fats] results in decreased expression of SPTLC2 mRNA; GW 4064 inhibits the reaction [[caffeic acid phenethyl ester co-treated with Dietary Fats] results in decreased expression of SPTLC2 mRNA]; NR1H4 protein affects the reaction [[caffeic acid phenethyl ester co-treated with Dietary Fats] results in decreased expression of SPTLC2 mRNA]

NCBI chr12:87,351,832...87,435,129
Ensembl chr12:87,351,832...87,435,129

G

signal transducer and activator of transcription 3

multiple interactions

caffeic acid phenethyl ester inhibits the reaction [Cyclosporine results in increased phosphorylation of STAT3 protein]
caffeic acid phenethyl ester analog affects the expression of and affects the phosphorylation of STAT3 protein

PMID:22155090 PMID:32125059

NCBI chr11:100,777,632...100,830,447
Ensembl chr11:100,775,924...100,830,366

G

striatin, calmodulin binding protein

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of STRN mRNA

NCBI chr17:78,957,327...79,043,990
Ensembl chr17:78,957,342...79,044,625

G

syntaxin 2

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of STX2 mRNA

NCBI chr 5:129,061,621...129,085,664
Ensembl chr 5:129,061,621...129,085,638

G

tec protein tyrosine kinase

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in increased expression of TEC mRNA

NCBI chr 5:72,913,061...73,025,997
Ensembl chr 5:72,913,059...73,025,826

G

thyroglobulin

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in increased expression of TG mRNA

NCBI chr15:66,542,606...66,722,570
Ensembl chr15:66,542,602...66,722,570

G

transforming growth factor, beta 2

multiple interactions

caffeic acid phenethyl ester inhibits the reaction [arsenite results in decreased expression of TGFB2 mRNA]

NCBI chr 1:186,354,984...186,441,504
Ensembl chr 1:186,354,989...186,438,186

G

transglutaminase 4 (prostate)

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in increased expression of TGM4 mRNA

NCBI chr 9:122,863,806...122,896,623
Ensembl chr 9:122,863,791...122,896,626

G

tyrosine hydroxylase

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of TH mRNA

NCBI chr 7:142,446,516...142,453,732
Ensembl chr 7:142,446,489...142,484,865

G

thymidine kinase 1

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of TK1 mRNA

NCBI chr11:117,706,345...117,716,913
Ensembl chr11:117,706,352...117,716,918

G

transketolase

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of TKT mRNA

NCBI chr14:30,271,088...30,296,681
Ensembl chr14:30,270,316...30,296,677

G

toll-like receptor 4

multiple interactions

caffeic acid phenethyl ester inhibits the reaction [Cadmium Chloride results in increased expression of TLR4 protein]

NCBI chr 4:66,745,788...66,765,338
Ensembl chr 4:66,745,821...66,848,521

G

tropomodulin 2

multiple interactions

caffeic acid phenethyl ester inhibits the reaction [Diethylnitrosamine results in increased expression of TMOD2 mRNA]

NCBI chr 9:75,472,903...75,518,620
Ensembl chr 9:75,472,903...75,518,607

G

tumor necrosis factor

multiple interactions
decreases expression

caffeic acid phenethyl ester inhibits the reaction [arsenite results in decreased expression of TNF mRNA]; caffeic acid phenethyl ester inhibits the reaction [Particulate Matter results in increased expression of TNF mRNA]; caffeic acid phenethyl ester inhibits the reaction [Particulate Matter results in increased expression of TNF protein]; caffeic acid phenethyl ester inhibits the reaction [TNF protein results in increased activity of RELA protein]; caffeic acid phenethyl ester inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]; caffeic acid phenethyl ester inhibits the reaction [Vehicle Emissions results in increased expression of TNF mRNA]; caffeic acid phenethyl ester inhibits the reaction [Vehicle Emissions results in increased expression of TNF protein]
caffeic acid phenethyl ester inhibits the reaction [Fructose results in increased expression of TNF protein]; caffeic acid phenethyl ester inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; caffeic acid phenethyl ester inhibits the reaction [Streptozocin results in increased expression of TNF protein]
caffeic acid phenethyl ester results in decreased expression of TNF protein
caffeic acid phenethyl ester inhibits the reaction [Cadmium Chloride results in increased expression of TNF protein]; caffeic acid phenethyl ester inhibits the reaction [Okadaic Acid results in increased expression of TNF protein]; caffeic acid phenethyl ester inhibits the reaction [Zymosan results in increased expression of TNF mRNA]; caffeic acid phenethyl ester inhibits the reaction [Zymosan results in increased expression of TNF protein]

PMID:10757128 PMID:11259437 PMID:15291876 PMID:16085347 PMID:16271621 More...

NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983

G

tumor necrosis factor receptor superfamily, member 10b

multiple interactions

[Benzo(a)pyrene co-treated with caffeic acid phenethyl ester] results in increased expression of TNFRSF10A mRNA

NCBI chr14:70,004,921...70,021,860
Ensembl chr14:70,004,921...70,021,860

G

tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin)

multiple interactions

caffeic acid phenethyl ester inhibits the reaction [Dexamethasone results in decreased expression of TNFRSF11B mRNA]

NCBI chr15:54,114,014...54,141,700
Ensembl chr15:54,114,015...54,141,880

G

tumor necrosis factor (ligand) superfamily, member 11

multiple interactions

caffeic acid phenethyl ester inhibits the reaction [Dexamethasone results in increased expression of TNFSF11 mRNA]

NCBI chr14:78,514,886...78,545,483
Ensembl chr14:78,514,885...78,545,483

G

troponin T1, skeletal, slow

multiple interactions

caffeic acid phenethyl ester inhibits the reaction [Diethylnitrosamine results in increased expression of TNNT1 mRNA]

NCBI chr 7:4,507,568...4,518,974
Ensembl chr 7:4,507,569...4,519,381

G

tripartite motif-containing 17

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in increased expression of TRIM17 mRNA

NCBI chr11:58,845,511...58,863,923
Ensembl chr11:58,845,511...58,863,924

G

transformation related protein 53

multiple interactions

caffeic acid phenethyl ester inhibits the reaction [Folic Acid results in increased expression of TP53 protein]; caffeic acid phenethyl ester inhibits the reaction [Mustard Compounds results in increased phosphorylation of TP53 protein]; caffeic acid phenethyl ester inhibits the reaction [Nitrogen Mustard Compounds results in increased phosphorylation of TP53 protein]; caffeic acid phenethyl ester inhibits the reaction [sodium arsenite results in decreased expression of TP53 protein]
caffeic acid phenethyl ester inhibits the reaction [Diethylnitrosamine results in decreased expression of TP53 mRNA]

PMID:17204746 PMID:20360939 PMID:22692362 PMID:26056802

NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699

G

trypsin 4

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of PRSS3 mRNA

NCBI chr 6:41,279,206...41,282,467
Ensembl chr 6:41,279,203...41,282,466

G

titin

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of TTN mRNA

NCBI chr 2:76,534,324...76,812,901
Ensembl chr 2:76,534,324...76,812,891

G

thioredoxin-like 1

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of TXNL1 mRNA

NCBI chr18:63,795,872...63,825,535
Ensembl chr18:63,794,165...63,841,872

G

tyrosinase

multiple interactions
increases oxidation
affects response to substance

[TYR protein affects the susceptibility to caffeic acid phenethyl ester] which affects the abundance of Glutathione; [TYR protein affects the susceptibility to caffeic acid phenethyl ester] which affects the abundance of Reactive Oxygen Species; ethylenediamine inhibits the reaction [[TYR protein results in increased oxidation of caffeic acid phenethyl ester] which results in increased oxidation of Ascorbic Acid]; ethylenediamine inhibits the reaction [[TYR protein results in increased oxidation of caffeic acid phenethyl ester] which results in increased oxidation of NAD]; ethylenediamine inhibits the reaction [TYR protein results in increased oxidation of caffeic acid phenethyl ester]; Glutathione inhibits the reaction [[TYR protein results in increased oxidation of caffeic acid phenethyl ester] which results in increased oxidation of Ascorbic Acid]; Glutathione inhibits the reaction [[TYR protein results in increased oxidation of caffeic acid phenethyl ester] which results in increased oxidation of NAD]; Glutathione inhibits the reaction [TYR protein results in increased oxidation of caffeic acid phenethyl ester]; TYR protein results in increased metabolism of and results in increased susceptibility to caffeic acid phenethyl ester
[TYR protein results in increased oxidation of caffeic acid phenethyl ester] which results in increased oxidation of Ascorbic Acid; [TYR protein results in increased oxidation of caffeic acid phenethyl ester] which results in increased oxidation of NAD; TYR protein results in increased oxidation of caffeic acid phenethyl ester

PMID:20685355 PMID:21458432

NCBI chr 7:87,073,979...87,142,637
Ensembl chr 7:87,073,979...87,142,720

G

vesicle-associated membrane protein 8

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of VAMP8 mRNA

NCBI chr 6:72,362,204...72,367,650
Ensembl chr 6:72,362,206...72,367,686

G

vascular cell adhesion molecule 1

multiple interactions

caffeic acid phenethyl ester inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]

NCBI chr 3:115,903,669...115,923,337
Ensembl chr 3:115,903,598...115,923,337

G

valosin containing protein (p97)/p47 complex interacting protein 1

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of VCPIP1 mRNA

NCBI chr 1:9,788,847...9,818,607
Ensembl chr 1:9,788,847...9,818,607

G

voltage-dependent anion channel 1

multiple interactions

[caffeic acid phenethyl ester co-treated with Dietary Fats] results in decreased expression of VDAC1 mRNA; GW 4064 inhibits the reaction [[caffeic acid phenethyl ester co-treated with Dietary Fats] results in decreased expression of VDAC1 mRNA]; NR1H4 protein affects the reaction [[caffeic acid phenethyl ester co-treated with Dietary Fats] results in decreased expression of VDAC1 mRNA]

NCBI chr11:52,251,905...52,280,224
Ensembl chr11:52,251,687...52,280,224

G

vascular endothelial growth factor A

multiple interactions

caffeic acid phenethyl ester inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of VEGFA protein]

NCBI chr17:46,327,919...46,343,303
Ensembl chr17:46,327,919...46,343,295

G

vitronectin

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of VTN mRNA

NCBI chr11:78,389,946...78,393,151
Ensembl chr11:78,389,917...78,393,150

G

Von Willebrand factor

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of VWF mRNA

NCBI chr 6:125,529,911...125,663,642
Ensembl chr 6:125,523,737...125,663,642

G

Werner helicase interacting protein 1

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of WRNIP1 mRNA

NCBI chr13:32,986,013...33,006,593
Ensembl chr13:32,986,021...33,006,592

G

X-linked inhibitor of apoptosis

decreases expression

caffeic acid phenethyl ester results in decreased expression of XIAP protein

NCBI chr X:41,148,483...41,198,541
Ensembl chr X:41,148,556...41,198,533

G

X-ray repair complementing defective repair in Chinese hamster cells 5

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of XRCC5 mRNA

NCBI chr 1:72,346,576...72,434,112
Ensembl chr 1:72,346,586...72,434,111

G

Y box protein 3

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of YBX3 mRNA

NCBI chr 6:131,341,821...131,365,413
Ensembl chr 6:131,341,818...131,365,439

G

YY1 transcription factor

multiple interactions

caffeic acid phenethyl ester inhibits the reaction [Diethylnitrosamine results in decreased expression of YY1 mRNA]

NCBI chr12:108,758,841...108,786,074
Ensembl chr12:108,758,899...108,786,074

G

zinc finger protein 180

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of ZFP180 mRNA

NCBI chr 7:23,781,303...23,807,134
Ensembl chr 7:23,781,349...23,807,138

G

zinc finger protein 37

multiple interactions

caffeic acid phenethyl ester inhibits the reaction [Diethylnitrosamine results in increased expression of ZFP37 mRNA]

NCBI chr 4:62,107,777...62,126,685
Ensembl chr 4:62,107,777...62,149,284

G

zinc finger protein 384

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of ZFP384 mRNA

NCBI chr 6:124,985,980...125,014,833
Ensembl chr 6:124,986,108...125,014,833

G

zinc fingers and homeoboxes 1

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of ZHX1 mRNA

NCBI chr15:57,910,399...57,939,904
Ensembl chr15:57,910,399...57,939,937

G

zinc finger with KRAB and SCAN domains 14

multiple interactions

[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of ZNF394 mRNA

NCBI chr 5:145,131,756...145,140,972
Ensembl chr 5:145,131,756...145,138,678

Plantamajoside

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

thymoma viral proto-oncogene 1

multiple interactions
decreases phosphorylation

plantamajoside inhibits the reaction [Isoproterenol results in increased phosphorylation of AKT1 protein]
AKT1 protein modified form inhibits the reaction [Metformin promotes the reaction [plantamajoside results in decreased phosphorylation of AKT1 protein]]; AKT1 protein modified form inhibits the reaction [Metformin promotes the reaction [plantamajoside results in decreased phosphorylation of GSK3B protein]]; Metformin promotes the reaction [plantamajoside results in decreased phosphorylation of AKT1 protein]

PMID:31009642 PMID:35350904

NCBI chr12:112,620,260...112,641,266
Ensembl chr12:112,620,255...112,641,318

G

beclin 1, autophagy related

multiple interactions

plantamajoside promotes the reaction [Metformin results in increased expression of BECN1 protein]

NCBI chr11:101,179,084...101,193,112
Ensembl chr11:101,176,778...101,193,112

G

caspase 3

multiple interactions

plantamajoside promotes the reaction [Metformin results in increased cleavage of CASP3 protein]

NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724

G

collagen, type I, alpha 1

multiple interactions

plantamajoside inhibits the reaction [Isoproterenol results in increased expression of COL1A1 mRNA]; plantamajoside inhibits the reaction [Isoproterenol results in increased expression of COL1A1 protein]

NCBI chr11:94,827,050...94,843,868
Ensembl chr11:94,827,050...94,843,868

G

collagen, type III, alpha 1

multiple interactions

plantamajoside inhibits the reaction [Isoproterenol results in increased expression of COL3A1 mRNA]; plantamajoside inhibits the reaction [Isoproterenol results in increased expression of COL3A1 protein]

NCBI chr 1:45,350,698...45,388,866
Ensembl chr 1:45,350,698...45,388,866

G

glycogen synthase kinase 3 beta

multiple interactions
decreases phosphorylation

plantamajoside inhibits the reaction [Isoproterenol results in increased phosphorylation of GSK3B protein]
plantamajoside results in decreased phosphorylation of GSK3B protein
AKT1 protein modified form inhibits the reaction [Metformin promotes the reaction [plantamajoside results in decreased phosphorylation of GSK3B protein]]; Metformin promotes the reaction [plantamajoside results in decreased phosphorylation of GSK3B protein]

PMID:31009642 PMID:35350904

NCBI chr16:37,909,363...38,066,446
Ensembl chr16:37,909,363...38,066,446

G

histone deacetylase 2

multiple interactions

plantamajoside inhibits the reaction [Isoproterenol results in increased phosphorylation of HDAC2 protein]

NCBI chr10:36,850,293...36,877,885
Ensembl chr10:36,850,540...36,877,885

G

myosin, heavy polypeptide 6, cardiac muscle, alpha

multiple interactions

plantamajoside inhibits the reaction [Isoproterenol results in increased expression of MYH6 protein]

NCBI chr14:55,179,378...55,205,553
Ensembl chr14:55,179,378...55,204,384

G

myosin, heavy polypeptide 7, cardiac muscle, beta

multiple interactions

plantamajoside inhibits the reaction [Isoproterenol results in increased expression of MYH7 mRNA]

NCBI chr14:55,208,141...55,232,083
Ensembl chr14:55,208,141...55,232,083

G

natriuretic peptide type A

multiple interactions

plantamajoside inhibits the reaction [Isoproterenol results in increased expression of NPPA mRNA]
plantamajoside inhibits the reaction [Isoproterenol results in increased expression of NPPA mRNA]; plantamajoside inhibits the reaction [Isoproterenol results in increased expression of NPPA protein]

NCBI chr 4:148,085,179...148,086,531
Ensembl chr 4:148,085,179...148,086,536

G

natriuretic peptide type B

multiple interactions

plantamajoside inhibits the reaction [Isoproterenol results in increased expression of NPPB mRNA]; plantamajoside inhibits the reaction [Isoproterenol results in increased expression of NPPB protein]

NCBI chr 4:148,070,264...148,071,662
Ensembl chr 4:148,070,245...148,071,662

G

poly (ADP-ribose) polymerase family, member 1

multiple interactions

plantamajoside promotes the reaction [Metformin results in increased cleavage of PARP1 protein]

NCBI chr 1:180,396,456...180,428,564
Ensembl chr 1:180,396,489...180,428,819

G

sequestosome 1

multiple interactions

plantamajoside promotes the reaction [Metformin results in decreased expression of SQSTM1 protein]

NCBI chr11:50,090,979...50,105,303
Ensembl chr11:50,090,193...50,101,654

rosmarinic acid

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

acetyl-Coenzyme A carboxylase alpha

multiple interactions

Rosmarinic Acid inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of ACACA mRNA]

NCBI chr11:84,020,461...84,292,477
Ensembl chr11:84,020,498...84,292,477

G

actin alpha 2, smooth muscle, aorta

multiple interactions
decreases expression

Rosmarinic Acid inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]
Rosmarinic Acid results in decreased expression of ACTA2 protein

NCBI chr19:34,217,736...34,232,985
Ensembl chr19:34,218,490...34,232,990

G

a disintegrin and metallopeptidase domain 17

decreases expression
multiple interactions

Rosmarinic Acid results in decreased expression of ADAM17 protein
[Rosmarinic Acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ADAM17 protein]] which affects the localization of PROCR protein; [Rosmarinic Acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ADAM17 protein]] which results in decreased cleavage of and results in decreased secretion of PROCR protein; [Rosmarinic Acid results in decreased expression of ADAM17 protein] inhibits the reaction [IL1B protein affects the localization of PROCR protein]; [Rosmarinic Acid results in decreased expression of ADAM17 protein] inhibits the reaction [IL1B protein results in increased cleavage of and results in increased secretion of PROCR protein]; [Rosmarinic Acid results in decreased expression of ADAM17 protein] inhibits the reaction [TNF protein affects the localization of PROCR protein]; [Rosmarinic Acid results in decreased expression of ADAM17 protein] inhibits the reaction [TNF protein results in increased cleavage of and results in increased secretion of PROCR protein]; Rosmarinic Acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ADAM17 protein]

NCBI chr12:21,373,510...21,423,633
Ensembl chr12:21,373,510...21,423,633

G

adiponectin, C1Q and collagen domain containing

multiple interactions

Rosmarinic Acid inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of ADIPOQ mRNA]; Rosmarinic Acid inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of ADIPOQ protein]

NCBI chr16:22,965,286...22,976,718
Ensembl chr16:22,965,286...22,976,778

G

apoptosis-inducing factor, mitochondrion-associated 1

multiple interactions

Rosmarinic Acid inhibits the reaction [Cadmium affects the localization of AIFM1 protein]; Rosmarinic Acid inhibits the reaction [Cisplatin affects the localization of AIFM1 protein]

PMID:21526214 PMID:23548128

NCBI chr X:47,563,821...47,602,440
Ensembl chr X:47,563,821...47,602,440

G

BCL2-associated X protein

multiple interactions

Rosmarinic Acid inhibits the reaction [Cisplatin results in increased expression of BAX protein]

NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322

G

B cell leukemia/lymphoma 2

multiple interactions

Rosmarinic Acid inhibits the reaction [Cisplatin results in decreased expression of BCL2 protein]

NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004

G

caspase 1

multiple interactions

Rosmarinic Acid inhibits the reaction [Cisplatin results in increased activity of CASP1 protein]

NCBI chr 9:5,298,517...5,307,281
Ensembl chr 9:5,298,508...5,307,290

G

caspase 3

multiple interactions
increases expression

Rosmarinic Acid inhibits the reaction [Doxorubicin results in increased expression of CASP3 protein]
Rosmarinic Acid inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased activity of CASP3 protein]; Rosmarinic Acid inhibits the reaction [Cadmium results in increased activity of CASP3 protein]; Rosmarinic Acid inhibits the reaction [Cisplatin results in increased activity of CASP3 protein]
Rosmarinic Acid results in increased expression of CASP3 mRNA

PMID:20966113 PMID:21526214 PMID:23548128 PMID:28815802 PMID:36863647

NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724

G

caspase 8

increases activity
increases expression

Rosmarinic Acid results in increased activity of CASP8 protein
Rosmarinic Acid results in increased expression of CASP8 mRNA

NCBI chr 1:58,834,553...58,886,663
Ensembl chr 1:58,834,533...58,886,662

G

caspase 9

multiple interactions

Rosmarinic Acid inhibits the reaction [Cisplatin results in increased activity of CASP9 protein]

NCBI chr 4:141,520,923...141,543,289
Ensembl chr 4:141,520,923...141,543,287

G

catalase

increases activity
increases expression
multiple interactions

Rosmarinic Acid results in increased activity of CAT protein
Rosmarinic Acid results in increased expression of CAT mRNA
Rosmarinic Acid inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased activity of CAT protein]; Rosmarinic Acid inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of CAT mRNA]

NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505

G

cellular communication network factor 2

multiple interactions
decreases expression

Rosmarinic Acid inhibits the reaction [TGFB1 protein results in increased expression of CCN2 protein]
Rosmarinic Acid results in decreased expression of CCN2 mRNA

NCBI chr10:24,471,340...24,474,581
Ensembl chr10:24,471,340...24,474,581

G

cyclin D1

multiple interactions

Rosmarinic Acid inhibits the reaction [TGFB1 protein results in increased expression of CCND1 protein]

NCBI chr 7:144,483,668...144,493,568
Ensembl chr 7:144,483,668...144,493,662

G

CD68 antigen

decreases expression

Rosmarinic Acid results in decreased expression of CD68 protein

NCBI chr11:69,555,039...69,556,996
Ensembl chr11:69,555,039...69,556,979

G

CCAAT/enhancer binding protein alpha

multiple interactions

Rosmarinic Acid affects the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of CEBPA mRNA]; Rosmarinic Acid inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of CEBPA protein]

NCBI chr 7:34,818,718...34,821,353
Ensembl chr 7:34,818,718...34,821,353

G

collagen, type I, alpha 1

multiple interactions
decreases expression

Rosmarinic Acid inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]
Rosmarinic Acid results in decreased expression of COL1A1 mRNA

PMID:27235791 PMID:28789951

NCBI chr11:94,827,050...94,843,868
Ensembl chr11:94,827,050...94,843,868

G

collagen, type III, alpha 1

decreases expression
multiple interactions

Rosmarinic Acid results in decreased expression of COL3A1 mRNA
Rosmarinic Acid inhibits the reaction [TGFB1 protein results in increased expression of COL3A1 mRNA]

NCBI chr 1:45,350,698...45,388,866
Ensembl chr 1:45,350,698...45,388,866

G

C-reactive protein, pentraxin-related

multiple interactions
affects expression

2-chloro-5-nitrobenzanilide inhibits the reaction [Rosmarinic Acid affects the expression of CRP protein]; T 0070907 inhibits the reaction [Rosmarinic Acid affects the expression of CRP protein]

NCBI chr 1:172,525,623...172,527,533
Ensembl chr 1:172,525,622...172,660,598

G

C-X-C motif chemokine ligand 3

multiple interactions
decreases expression

Rosmarinic Acid inhibits the reaction [Particulate Matter results in increased expression of CXCL1 protein]; Rosmarinic Acid inhibits the reaction [Vehicle Emissions results in increased expression of CXCL1 protein]
Rosmarinic Acid results in decreased expression of CXCL1 mRNA

PMID:12684091 PMID:26804033

NCBI chr 5:90,933,960...90,935,952
Ensembl chr 5:90,933,962...90,937,459

G

desmin

multiple interactions

Rosmarinic Acid inhibits the reaction [TGFB1 protein results in increased expression of DES protein]

NCBI chr 1:75,336,936...75,345,223
Ensembl chr 1:75,336,973...75,345,223

G

DNA methyltransferase 1

decreases expression

Rosmarinic Acid results in decreased expression of DNMT1 protein

NCBI chr 9:20,818,501...20,871,084
Ensembl chr 9:20,818,505...20,871,184

G

fatty acid binding protein 4, adipocyte

multiple interactions

Rosmarinic Acid inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of FABP4 mRNA]

NCBI chr 3:10,269,406...10,273,653
Ensembl chr 3:10,269,148...10,273,636

G

fatty acid synthase

multiple interactions

Rosmarinic Acid inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of FASN mRNA]

NCBI chr11:120,696,784...120,715,992
Ensembl chr11:120,696,672...120,715,373

G

fibronectin 1

decreases expression

Rosmarinic Acid results in decreased expression of FN1 mRNA

NCBI chr 1:71,624,632...71,692,439
Ensembl chr 1:71,624,679...71,692,359

G

FBJ osteosarcoma oncogene

decreases expression

Rosmarinic Acid results in decreased expression of FOS protein

NCBI chr12:85,520,664...85,524,048
Ensembl chr12:85,520,664...85,524,047

G

glutamic pyruvic transaminase, soluble

decreases activity

Rosmarinic Acid results in decreased activity of GPT protein

NCBI chr15:76,580,926...76,583,875
Ensembl chr15:76,579,916...76,583,886

G

glutathione peroxidase 1

increases expression
multiple interactions

Rosmarinic Acid results in increased expression of GPX1 mRNA
Rosmarinic Acid inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of GPX1 mRNA]

NCBI chr 9:108,216,279...108,217,541
Ensembl chr 9:108,216,102...108,217,542

G

glutathione S-transferase omega 1

increases expression
multiple interactions

Rosmarinic Acid results in increased expression of GSTO1 mRNA
Rosmarinic Acid inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of GSTO1 mRNA]

NCBI chr19:47,843,412...47,853,229
Ensembl chr19:47,843,409...47,853,229

G

high mobility group box 1

decreases expression

Rosmarinic Acid results in decreased expression of HMGB1 protein

NCBI chr 5:148,983,512...148,989,867
Ensembl chr 5:148,983,512...149,121,299

G

heme oxygenase 1

multiple interactions
increases expression

Rosmarinic Acid inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in increased expression of HMOX1 mRNA]
Rosmarinic Acid results in increased expression of HMOX1 mRNA

NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217

G

interleukin 10

multiple interactions

Rosmarinic Acid inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in decreased expression of IL10 mRNA]

NCBI chr 1:130,947,459...130,952,707
Ensembl chr 1:130,947,582...130,952,711

G

interleukin 17A

multiple interactions

Rosmarinic Acid inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in decreased expression of IL17A mRNA]

NCBI chr 1:20,801,129...20,804,720
Ensembl chr 1:20,801,129...20,804,720

G

interleukin 1 beta

multiple interactions
decreases expression

[Rosmarinic Acid results in decreased expression of ADAM17 protein] inhibits the reaction [IL1B protein affects the localization of PROCR protein]; [Rosmarinic Acid results in decreased expression of ADAM17 protein] inhibits the reaction [IL1B protein results in increased cleavage of and results in increased secretion of PROCR protein]; Rosmarinic Acid inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of IL1B mRNA]
Rosmarinic Acid inhibits the reaction [Cadmium results in increased expression of IL1B protein]; Rosmarinic Acid inhibits the reaction [Particulate Matter results in increased expression of IL1B protein]; Rosmarinic Acid inhibits the reaction [Vehicle Emissions results in increased expression of IL1B protein]
Rosmarinic Acid results in decreased expression of IL1B mRNA; Rosmarinic Acid results in decreased expression of IL1B protein

PMID:12684091 PMID:23548128 PMID:23774263 PMID:25455894 PMID:28789951 More...

NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059

G

interleukin 6

decreases expression
affects expression
multiple interactions
increases expression

Rosmarinic Acid results in decreased expression of IL6 mRNA
Rosmarinic Acid affects the expression of IL6 protein
2-chloro-5-nitrobenzanilide inhibits the reaction [Rosmarinic Acid affects the expression of IL6 protein]; T 0070907 inhibits the reaction [Rosmarinic Acid affects the expression of IL6 protein]
Rosmarinic Acid inhibits the reaction [Cadmium results in increased expression of IL6 protein]
Rosmarinic Acid results in decreased expression of IL6 protein
Rosmarinic Acid results in increased expression of IL6 mRNA

PMID:23548128 PMID:26804033 PMID:28744220 PMID:28789951

NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979

G

insulin II

multiple interactions

[Rosmarinic Acid co-treated with Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in decreased expression of NFE2L2 mRNA; [Rosmarinic Acid co-treated with Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in decreased expression of TGFB1 mRNA; [Rosmarinic Acid co-treated with Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of NFKBIA mRNA; Rosmarinic Acid affects the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of CEBPA mRNA]; Rosmarinic Acid affects the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of PPARGC1A mRNA]; Rosmarinic Acid inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in decreased expression of IL10 mRNA]; Rosmarinic Acid inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in decreased expression of IL17A mRNA]; Rosmarinic Acid inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of ACACA mRNA]; Rosmarinic Acid inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of ADIPOQ mRNA]; Rosmarinic Acid inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of ADIPOQ protein]; Rosmarinic Acid inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of CEBPA protein]; Rosmarinic Acid inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of FABP4 mRNA]; Rosmarinic Acid inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of FASN mRNA]; Rosmarinic Acid inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of IL1B mRNA]; Rosmarinic Acid inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of PPARA mRNA]; Rosmarinic Acid inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of PPARD mRNA]; Rosmarinic Acid inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of PPARG protein]; Rosmarinic Acid inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of SREBF1 mRNA]; Rosmarinic Acid inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of UCP1 mRNA]

NCBI chr 7:142,232,393...142,233,463
Ensembl chr 7:142,232,393...142,297,118

G

jun proto-oncogene

decreases phosphorylation

Rosmarinic Acid results in decreased phosphorylation of JUN protein

NCBI chr 4:94,937,273...94,940,459
Ensembl chr 4:94,937,271...94,940,459

G

potassium channel, subfamily U, member 1

decreases activity

Rosmarinic Acid results in decreased activity of KCNU1 protein

NCBI chr 8:26,338,656...26,427,971
Ensembl chr 8:26,339,651...26,427,967

G

kelch-like ECH-associated protein 1

multiple interactions
decreases expression

Rosmarinic Acid inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in increased expression of KEAP1 protein]
Rosmarinic Acid results in decreased expression of KEAP1 protein

NCBI chr 9:21,141,026...21,150,628
Ensembl chr 9:21,141,026...21,150,657

G

monoamine oxidase A

decreases activity

Rosmarinic Acid results in decreased activity of MAOA protein

NCBI chr X:16,485,937...16,554,051
Ensembl chr X:16,485,937...16,554,057

G

monoamine oxidase B

decreases activity

Rosmarinic Acid results in decreased activity of MAOB protein

NCBI chr X:16,575,520...16,683,605
Ensembl chr X:16,575,521...16,683,605

G

mitogen-activated protein kinase kinase kinase 7

decreases phosphorylation

Rosmarinic Acid results in decreased phosphorylation of MAP3K7 protein

NCBI chr 4:31,963,659...32,023,470
Ensembl chr 4:31,964,097...32,023,467

G

mitogen-activated protein kinase 1

decreases phosphorylation

Rosmarinic Acid results in decreased phosphorylation of MAPK1 protein

NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317

G

mitogen-activated protein kinase 3

decreases phosphorylation

Rosmarinic Acid results in decreased phosphorylation of MAPK3 protein

NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991

G

mitogen-activated protein kinase 8

decreases phosphorylation

Rosmarinic Acid results in decreased phosphorylation of MAPK8 protein

NCBI chr14:33,099,855...33,169,213
Ensembl chr14:33,099,855...33,169,115

G

mitogen-activated protein kinase 9

decreases phosphorylation

Rosmarinic Acid results in decreased phosphorylation of MAPK9 protein

NCBI chr11:49,737,558...49,777,248
Ensembl chr11:49,737,578...49,777,248

G

matrix metallopeptidase 2

decreases expression

Rosmarinic Acid results in decreased expression of MMP2 mRNA; Rosmarinic Acid results in decreased expression of MMP2 protein

NCBI chr 8:93,553,920...93,580,049
Ensembl chr 8:93,553,919...93,580,048

G

matrix metallopeptidase 9

decreases expression

Rosmarinic Acid results in decreased expression of MMP9 mRNA; Rosmarinic Acid results in decreased expression of MMP9 protein

NCBI chr 2:164,782,246...164,797,770
Ensembl chr 2:164,782,700...164,797,770

G

myeloperoxidase

decreases expression

Rosmarinic Acid results in decreased expression of MPO protein

NCBI chr11:87,684,610...87,695,238
Ensembl chr11:87,684,407...87,695,239

G

myeloid differentiation primary response gene 88

decreases expression

Rosmarinic Acid results in decreased expression of MYD88 protein

NCBI chr 9:119,165,000...119,169,084
Ensembl chr 9:119,165,000...119,170,477

G

nuclear factor, erythroid derived 2, like 2

increases expression
multiple interactions

Rosmarinic Acid results in increased expression of NFE2L2 mRNA; Rosmarinic Acid results in increased expression of NFE2L2 protein
[lead acetate results in increased abundance of Lead] inhibits the reaction [Rosmarinic Acid results in increased expression of NFE2L2 protein]; [Rosmarinic Acid co-treated with Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in decreased expression of NFE2L2 mRNA; Rosmarinic Acid affects the reaction [[lead acetate results in increased abundance of Lead] which results in increased expression of NFE2L2 mRNA]

PMID:31610155 PMID:33476690

NCBI chr 2:75,505,860...75,535,007
Ensembl chr 2:75,505,857...75,534,985

G

nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha

multiple interactions

[Rosmarinic Acid co-treated with Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of NFKBIA mRNA
Rosmarinic Acid inhibits the reaction [Cisplatin results in increased degradation of NFKBIA protein]

PMID:21526214 PMID:33476690

NCBI chr12:55,536,194...55,539,432
Ensembl chr12:55,536,195...55,539,432

G

NLR family, pyrin domain containing 3

decreases expression

Rosmarinic Acid results in decreased expression of NLRP3 mRNA

NCBI chr11:59,432,395...59,457,781
Ensembl chr11:59,432,394...59,457,782

G

nitric oxide synthase 2, inducible

multiple interactions
decreases expression

Rosmarinic Acid inhibits the reaction [Doxorubicin results in increased expression of NOS2 protein]
Rosmarinic Acid results in decreased expression of NOS2 protein

PMID:25455894 PMID:28815802

NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080

G

nitric oxide synthase 3, endothelial cell

decreases expression

Rosmarinic Acid results in decreased expression of NOS3 protein

NCBI chr 5:24,569,772...24,589,472
Ensembl chr 5:24,569,808...24,589,472

G

NAD(P)H dehydrogenase, quinone 1

increases expression
multiple interactions

Rosmarinic Acid results in increased expression of NQO1 mRNA
Rosmarinic Acid inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of NQO1 mRNA]

NCBI chr 8:108,114,856...108,139,012
Ensembl chr 8:108,114,857...108,129,838

G

8-oxoguanine DNA-glycosylase 1

increases expression

Rosmarinic Acid results in increased expression of OGG1 mRNA

NCBI chr 6:113,303,959...113,311,149
Ensembl chr 6:113,303,933...113,312,029

G

poly (ADP-ribose) glycohydrolase

decreases activity

Rosmarinic Acid results in decreased activity of PARG protein

NCBI chr14:31,923,900...32,020,671
Ensembl chr14:31,923,906...32,019,507

G

peroxisome proliferator activated receptor alpha

multiple interactions

Rosmarinic Acid inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of PPARA mRNA]

NCBI chr15:85,619,112...85,691,052
Ensembl chr15:85,619,184...85,687,020

G

peroxisome proliferator activator receptor delta

multiple interactions

Rosmarinic Acid inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of PPARD mRNA]

NCBI chr17:28,451,715...28,520,446
Ensembl chr17:28,451,674...28,520,448

G

peroxisome proliferator activated receptor gamma

affects expression
multiple interactions

Rosmarinic Acid affects the expression of PPARG mRNA; Rosmarinic Acid affects the expression of PPARG protein
2-chloro-5-nitrobenzanilide inhibits the reaction [Rosmarinic Acid affects the expression of PPARG mRNA]; 2-chloro-5-nitrobenzanilide inhibits the reaction [Rosmarinic Acid affects the expression of PPARG protein]; T 0070907 inhibits the reaction [Rosmarinic Acid affects the expression of PPARG mRNA]; T 0070907 inhibits the reaction [Rosmarinic Acid affects the expression of PPARG protein]
Rosmarinic Acid inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of PPARG protein]

PMID:28744220 PMID:33476690

NCBI chr 6:115,337,828...115,467,365
Ensembl chr 6:115,337,912...115,467,360

G

peroxisome proliferative activated receptor, gamma, coactivator 1 alpha

multiple interactions

Rosmarinic Acid affects the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of PPARGC1A mRNA]

NCBI chr 5:51,611,591...52,273,316
Ensembl chr 5:51,611,592...51,725,068

G

protein C receptor, endothelial

multiple interactions
affects localization

Rosmarinic Acid results in decreased cleavage of and results in decreased secretion of PROCR protein
Rosmarinic Acid affects the localization of PROCR protein
[Rosmarinic Acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ADAM17 protein]] which affects the localization of PROCR protein; [Rosmarinic Acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ADAM17 protein]] which results in decreased cleavage of and results in decreased secretion of PROCR protein; [Rosmarinic Acid results in decreased expression of ADAM17 protein] inhibits the reaction [IL1B protein affects the localization of PROCR protein]; [Rosmarinic Acid results in decreased expression of ADAM17 protein] inhibits the reaction [IL1B protein results in increased cleavage of and results in increased secretion of PROCR protein]; [Rosmarinic Acid results in decreased expression of ADAM17 protein] inhibits the reaction [TNF protein affects the localization of PROCR protein]; [Rosmarinic Acid results in decreased expression of ADAM17 protein] inhibits the reaction [TNF protein results in increased cleavage of and results in increased secretion of PROCR protein]; Rosmarinic Acid inhibits the reaction [Tetradecanoylphorbol Acetate affects the localization of PROCR protein]; Rosmarinic Acid results in decreased cleavage of and results in decreased secretion of PROCR protein

NCBI chr 2:155,592,159...155,597,391
Ensembl chr 2:155,593,037...155,597,391

G

v-rel reticuloendotheliosis viral oncogene homolog A (avian)

multiple interactions
decreases phosphorylation
affects localization
affects expression

2-chloro-5-nitrobenzanilide inhibits the reaction [Rosmarinic Acid affects the expression of RELA mRNA]; 2-chloro-5-nitrobenzanilide inhibits the reaction [Rosmarinic Acid affects the expression of RELA protein]; T 0070907 inhibits the reaction [Rosmarinic Acid affects the expression of RELA mRNA]; T 0070907 inhibits the reaction [Rosmarinic Acid affects the expression of RELA protein]
Rosmarinic Acid inhibits the reaction [Cisplatin affects the localization of RELA protein]
Rosmarinic Acid results in decreased phosphorylation of RELA protein
Rosmarinic Acid affects the localization of RELA protein
Rosmarinic Acid affects the expression of RELA mRNA; Rosmarinic Acid affects the expression of RELA protein

PMID:21526214 PMID:25455894 PMID:28744220 PMID:28789951

NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158

G

serine (or cysteine) peptidase inhibitor, clade E, member 1

decreases expression

Rosmarinic Acid results in decreased expression of SERPINE1 mRNA

NCBI chr 5:137,090,358...137,101,126
Ensembl chr 5:137,090,358...137,101,122

G

superoxide dismutase 1, soluble

multiple interactions
increases expression

Rosmarinic Acid inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of SOD1 mRNA]
Rosmarinic Acid results in increased expression of SOD1 mRNA

NCBI chr16:90,017,650...90,023,221
Ensembl chr16:90,017,642...90,023,217

G

superoxide dismutase 2, mitochondrial

multiple interactions
increases expression

Rosmarinic Acid inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of SOD2 mRNA]
Rosmarinic Acid results in increased expression of SOD2 mRNA

NCBI chr17:13,226,726...13,237,006
Ensembl chr17:13,225,733...13,258,950

G

sterol regulatory element binding transcription factor 1

multiple interactions

Rosmarinic Acid inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of SREBF1 mRNA]

NCBI chr11:60,089,910...60,113,407
Ensembl chr11:60,089,915...60,113,407

G

transforming growth factor, beta 1

multiple interactions
decreases expression

[Rosmarinic Acid co-treated with Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in decreased expression of TGFB1 mRNA
Rosmarinic Acid results in decreased expression of TGFB1 protein
Rosmarinic Acid inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]; Rosmarinic Acid inhibits the reaction [TGFB1 protein results in increased expression of CCN2 protein]; Rosmarinic Acid inhibits the reaction [TGFB1 protein results in increased expression of CCND1 protein]; Rosmarinic Acid inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]; Rosmarinic Acid inhibits the reaction [TGFB1 protein results in increased expression of COL3A1 mRNA]; Rosmarinic Acid inhibits the reaction [TGFB1 protein results in increased expression of DES protein]; Rosmarinic Acid inhibits the reaction [TGFB1 protein results in increased expression of VIM protein]

PMID:28789951 PMID:33476690

NCBI chr 7:25,386,406...25,404,503
Ensembl chr 7:25,386,427...25,404,502

G

toll-like receptor 4

decreases expression

Rosmarinic Acid results in decreased expression of TLR4 protein

NCBI chr 4:66,745,788...66,765,338
Ensembl chr 4:66,745,821...66,848,521

G

tumor necrosis factor

affects expression
multiple interactions
decreases expression

Rosmarinic Acid affects the expression of TNF protein
[Rosmarinic Acid results in decreased expression of ADAM17 protein] inhibits the reaction [TNF protein affects the localization of PROCR protein]; [Rosmarinic Acid results in decreased expression of ADAM17 protein] inhibits the reaction [TNF protein results in increased cleavage of and results in increased secretion of PROCR protein]
Rosmarinic Acid results in decreased expression of TNF mRNA; Rosmarinic Acid results in decreased expression of TNF protein
2-chloro-5-nitrobenzanilide inhibits the reaction [Rosmarinic Acid affects the expression of TNF protein]; Rosmarinic Acid inhibits the reaction [Doxorubicin results in increased expression of TNF protein]; T 0070907 inhibits the reaction [Rosmarinic Acid affects the expression of TNF protein]

PMID:23774263 PMID:25455894 PMID:28744220 PMID:28789951 PMID:28815802

NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983

G

transferrin

multiple interactions

[Rosmarinic Acid co-treated with Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in decreased expression of NFE2L2 mRNA; [Rosmarinic Acid co-treated with Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in decreased expression of TGFB1 mRNA; [Rosmarinic Acid co-treated with Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of NFKBIA mRNA; Rosmarinic Acid affects the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of CEBPA mRNA]; Rosmarinic Acid affects the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of PPARGC1A mRNA]; Rosmarinic Acid inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in decreased expression of IL10 mRNA]; Rosmarinic Acid inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in decreased expression of IL17A mRNA]; Rosmarinic Acid inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of ACACA mRNA]; Rosmarinic Acid inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of ADIPOQ mRNA]; Rosmarinic Acid inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of ADIPOQ protein]; Rosmarinic Acid inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of CEBPA protein]; Rosmarinic Acid inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of FABP4 mRNA]; Rosmarinic Acid inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of FASN mRNA]; Rosmarinic Acid inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of IL1B mRNA]; Rosmarinic Acid inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of PPARA mRNA]; Rosmarinic Acid inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of PPARD mRNA]; Rosmarinic Acid inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of PPARG protein]; Rosmarinic Acid inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of SREBF1 mRNA]; Rosmarinic Acid inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of UCP1 mRNA]

NCBI chr 9:103,086,075...103,107,485
Ensembl chr 9:103,081,200...103,107,643

G

uncoupling protein 1 (mitochondrial, proton carrier)

multiple interactions

Rosmarinic Acid inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of UCP1 mRNA]

NCBI chr 8:84,016,977...84,025,085
Ensembl chr 8:84,016,981...84,025,081

G

vimentin

multiple interactions

Rosmarinic Acid inhibits the reaction [TGFB1 protein results in increased expression of VIM protein]

NCBI chr 2:13,579,122...13,587,637
Ensembl chr 2:13,578,738...13,587,637

sinapic acid

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

acyl-CoA thioesterase 2

increases expression

sinapinic acid analog results in increased expression of ACOT2 mRNA

NCBI chr12:84,034,635...84,040,651
Ensembl chr12:84,034,635...84,040,647

G

advanced glycosylation end product-specific receptor

multiple interactions

sinapinic acid inhibits the reaction [lead acetate results in increased expression of AGER mRNA]

NCBI chr17:34,816,545...34,819,911
Ensembl chr17:34,816,836...34,819,910

G

apoptotic peptidase activating factor 1

multiple interactions

sinapinic acid inhibits the reaction [lead acetate results in increased expression of APAF1 mRNA]

NCBI chr10:90,825,173...90,918,688
Ensembl chr10:90,825,173...90,918,632

G

Rho guanine nucleotide exchange factor 19

decreases expression

sinapinic acid analog results in decreased expression of ARHGEF19 mRNA

NCBI chr 4:140,966,916...140,985,226
Ensembl chr 4:140,966,810...140,984,875

G

Rho/Rac guanine nucleotide exchange factor 2

increases expression

sinapinic acid analog results in increased expression of ARHGEF2 mRNA

NCBI chr 3:88,500,427...88,556,839
Ensembl chr 3:88,513,273...88,555,359

G

activating transcription factor 3

increases expression

sinapinic acid analog results in increased expression of ATF3 mRNA

NCBI chr 1:190,902,493...190,915,530
Ensembl chr 1:190,902,493...190,950,236

G

activating transcription factor 4

increases expression

sinapinic acid analog results in increased expression of ATF4 mRNA

NCBI chr15:80,139,385...80,141,746
Ensembl chr15:80,139,385...80,141,742

G

BCL2-associated X protein

multiple interactions

sinapinic acid inhibits the reaction [lead acetate results in increased expression of BAX mRNA]; sinapinic acid inhibits the reaction [Methotrexate results in increased expression of BAX protein]

PMID:33720507 PMID:37471654

NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322

G

B cell leukemia/lymphoma 2

multiple interactions

sinapinic acid inhibits the reaction [lead acetate results in decreased expression of BCL2 mRNA]; sinapinic acid inhibits the reaction [Methotrexate results in decreased expression of BCL2 protein]

PMID:33720507 PMID:37471654

NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004

G

B cell leukemia/lymphoma 3

decreases expression

sinapinic acid analog results in decreased expression of BCL3 mRNA

NCBI chr 7:19,542,387...19,556,691
Ensembl chr 7:19,542,387...19,556,695

G

B cell CLL/lymphoma 9-like

decreases expression

sinapinic acid analog results in decreased expression of BCL9L mRNA

NCBI chr 9:44,394,103...44,423,203
Ensembl chr 9:44,394,122...44,423,193

G

calreticulin

increases expression

sinapinic acid analog results in increased expression of CALR mRNA

NCBI chr 8:85,568,717...85,573,560
Ensembl chr 8:85,568,479...85,573,563

G

CASK interacting protein 1

decreases expression

sinapinic acid analog results in decreased expression of CASKIN1 mRNA

NCBI chr17:24,706,871...24,727,883
Ensembl chr17:24,707,575...24,727,645

G

caspase 3

multiple interactions

sinapinic acid inhibits the reaction [lead acetate results in increased expression of CASP3 mRNA]; sinapinic acid inhibits the reaction [Methotrexate affects the localization of CASP3 protein]; sinapinic acid inhibits the reaction [Methotrexate results in increased expression of CASP3 protein]

PMID:33720507 PMID:37471654

NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724

G

catalase

multiple interactions

sinapinic acid inhibits the reaction [lead acetate results in decreased activity of CAT protein]; sinapinic acid inhibits the reaction [Methotrexate results in decreased expression of CAT protein]

PMID:33720507 PMID:37471654

NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505

G

ChaC, cation transport regulator 1

increases expression

sinapinic acid analog results in increased expression of CHAC1 mRNA

NCBI chr 2:119,181,723...119,184,807
Ensembl chr 2:119,181,710...119,184,862

G

DNA-damage inducible transcript 3

increases expression

sinapinic acid analog results in increased expression of DDIT3 mRNA

NCBI chr10:127,126,662...127,132,160
Ensembl chr10:127,126,643...127,132,157
Ensembl chr10:127,126,643...127,132,157

G

eukaryotic translation initiation factor 4E binding protein 1

increases expression

sinapinic acid analog results in increased expression of EIF4EBP1 mRNA

NCBI chr 8:27,750,355...27,765,684
Ensembl chr 8:27,750,357...27,766,702

G

family with sequence similarity 53, member B

decreases expression

sinapinic acid analog results in decreased expression of FAM53B mRNA

NCBI chr 7:132,313,813...132,429,518
Ensembl chr 7:132,313,811...132,415,615

G

family with sequence similarity 78, member A

decreases expression

sinapinic acid analog results in decreased expression of FAM78A mRNA

NCBI chr 2:31,932,720...31,977,484
Ensembl chr 2:31,940,098...31,954,923
Ensembl chr 2:31,940,098...31,954,923

G

forkhead box O6

decreases expression

sinapinic acid analog results in decreased expression of FOXO6 mRNA

NCBI chr 4:120,124,275...120,144,458
Ensembl chr 4:120,124,276...120,144,546

G

glucose-6-phosphate dehydrogenase X-linked

decreases activity

sinapinic acid results in decreased activity of G6PD protein

NCBI chr X:73,453,089...73,472,486
Ensembl chr X:73,453,089...73,472,800

G

G protein-coupled receptor, family C, group 5, member B

decreases expression

sinapinic acid analog results in decreased expression of GPRC5B mRNA

NCBI chr 7:118,571,263...118,594,434
Ensembl chr 7:118,571,270...118,594,434

G

glutamic pyruvic transaminase, soluble

multiple interactions

sinapinic acid inhibits the reaction [Methotrexate results in increased expression of GPT protein]

NCBI chr15:76,580,926...76,583,875
Ensembl chr15:76,579,916...76,583,886

G

GRAM domain containing 2A

increases expression

sinapinic acid analog results in increased expression of GRAMD2A mRNA

NCBI chr 9:59,587,116...59,626,156
Ensembl chr 9:59,587,427...59,626,157

G

heme oxygenase 1

multiple interactions

sinapinic acid inhibits the reaction [lead acetate results in decreased expression of HMOX1 mRNA]; sinapinic acid inhibits the reaction [Methotrexate results in decreased expression of HMOX1 protein]

PMID:33720507 PMID:37471654

NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217

G

heat shock protein 1B

decreases expression

sinapinic acid analog results in decreased expression of HSPA1B mRNA

NCBI chr17:35,175,405...35,178,214
Ensembl chr17:35,175,412...35,178,214

G

interleukin 1 beta

multiple interactions

sinapinic acid inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]
2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [sinapinic acid inhibits the reaction [Cisplatin results in increased expression of IL1B protein]]; sinapinic acid inhibits the reaction [Cisplatin results in increased expression of IL1B protein]; sinapinic acid inhibits the reaction [lead acetate results in increased expression of IL1B mRNA]; sinapinic acid inhibits the reaction [Methotrexate results in increased expression of IL1B protein]

PMID:18841975 PMID:32742113 PMID:33720507 PMID:37471654

NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059

G

Jun dimerization protein 2

increases expression

sinapinic acid analog results in increased expression of JDP2 mRNA

NCBI chr12:85,645,190...85,686,652
Ensembl chr12:85,645,801...85,686,652

G

lemur tyrosine kinase 3

decreases expression

sinapinic acid analog results in decreased expression of LMTK3 mRNA

NCBI chr 7:45,432,577...45,456,315
Ensembl chr 7:45,433,162...45,453,568

G

leucine zipper, putative tumor suppressor 1

decreases expression

sinapinic acid analog results in decreased expression of LZTS1 mRNA

NCBI chr 8:69,585,311...69,636,901
Ensembl chr 8:69,585,321...69,636,877

G

mitogen-activated protein kinase 14

multiple interactions

sinapinic acid inhibits the reaction [lead acetate results in increased expression of MAPK14 mRNA]

NCBI chr17:28,910,316...28,967,379
Ensembl chr17:28,910,303...28,967,380

G

mitogen-activated protein kinase 15

multiple interactions

sinapinic acid inhibits the reaction [lead acetate results in increased expression of MAPK15 mRNA]

NCBI chr15:75,865,581...75,871,002
Ensembl chr15:75,865,618...75,871,003

G

mitogen-activated protein kinase 8

multiple interactions

sinapinic acid inhibits the reaction [lead acetate results in increased expression of MAPK8 mRNA]

NCBI chr14:33,099,855...33,169,213
Ensembl chr14:33,099,855...33,169,115

G

myoglobin

multiple interactions

sinapinic acid inhibits the reaction [Isoproterenol results in increased expression of MB protein]

NCBI chr15:76,899,687...76,934,868
Ensembl chr15:76,899,687...76,934,870

G

myeloperoxidase

multiple interactions

sinapinic acid inhibits the reaction [Methotrexate results in increased expression of MPO protein]

NCBI chr11:87,684,610...87,695,238
Ensembl chr11:87,684,407...87,695,239

G

methylenetetrahydrofolate dehydrogenase (NAD+ dependent), methenyltetrahydrofolate cyclohydrolase

increases expression

sinapinic acid analog results in increased expression of MTHFD2 mRNA

NCBI chr 6:83,282,686...83,302,926
Ensembl chr 6:83,282,673...83,302,890

G

mevalonate kinase

increases expression

sinapinic acid analog results in increased expression of MVK mRNA

NCBI chr 5:114,582,324...114,598,652
Ensembl chr 5:114,582,330...114,598,652

G

nuclear paraspeckle assembly transcript 1 (non-protein coding)

increases expression

sinapinic acid analog results in increased expression of NEAT1 mRNA

NCBI chr19:5,874,736...5,895,508
Ensembl chr19:5,874,736...5,895,898

G

nuclear factor, erythroid derived 2, like 2

multiple interactions

sinapinic acid inhibits the reaction [lead acetate results in decreased expression of NFE2L2 mRNA]

NCBI chr 2:75,505,860...75,535,007
Ensembl chr 2:75,505,857...75,534,985

G

nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105

multiple interactions

sinapinic acid inhibits the reaction [Lipopolysaccharides affects the localization of NFKB1 protein]
sinapinic acid inhibits the reaction [lead acetate results in increased expression of NFKB1 mRNA]

PMID:18841975 PMID:37471654

NCBI chr 3:135,290,416...135,397,422
Ensembl chr 3:135,290,416...135,397,308

G

nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha

multiple interactions

sinapinic acid inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased degradation of NFKBIA protein]

NCBI chr12:55,536,194...55,539,432
Ensembl chr12:55,536,195...55,539,432

G

NLR family, pyrin domain containing 3

multiple interactions

sinapinic acid inhibits the reaction [lead acetate results in increased expression of NLRP3 mRNA]

NCBI chr11:59,432,395...59,457,781
Ensembl chr11:59,432,394...59,457,782

G

nucleolar protein 4-like

decreases expression

sinapinic acid analog results in decreased expression of NOL4L mRNA

NCBI chr 2:153,249,381...153,371,869
Ensembl chr 2:153,249,382...153,371,891

G

nitric oxide synthase 2, inducible

multiple interactions

sinapinic acid inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; sinapinic acid inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]

NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080

G

NAD(P)H dehydrogenase, quinone 1

multiple interactions

sinapinic acid inhibits the reaction [lead acetate results in decreased expression of NQO1 mRNA]

NCBI chr 8:108,114,856...108,139,012
Ensembl chr 8:108,114,857...108,129,838

G

oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)

multiple interactions

sinapinic acid inhibits the reaction [Isoproterenol results in decreased activity of OGDH protein]

NCBI chr11:6,241,597...6,309,094
Ensembl chr11:6,241,633...6,306,642

G

pyrimidinergic receptor P2Y, G-protein coupled, 6

decreases expression

sinapinic acid analog results in decreased expression of P2RY6 mRNA

NCBI chr 7:100,586,837...100,628,528
Ensembl chr 7:100,586,837...100,623,856

G

phosphogluconate dehydrogenase

decreases activity

sinapinic acid results in decreased activity of PGD protein

NCBI chr 4:149,234,448...149,251,162
Ensembl chr 4:149,234,448...149,251,228

G

proline rich 5 (renal)

decreases expression

sinapinic acid analog results in decreased expression of PRR5 mRNA

NCBI chr15:84,547,407...84,590,610
Ensembl chr15:84,553,821...84,587,874

G

proline-rich transmembrane protein 2

decreases expression

sinapinic acid analog results in decreased expression of PRRT2 mRNA

NCBI chr 7:126,616,707...126,620,800
Ensembl chr 7:126,616,703...126,620,383

G

prostaglandin-endoperoxide synthase 2

multiple interactions

sinapinic acid inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; sinapinic acid inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]
sinapinic acid inhibits the reaction [lead acetate results in increased expression of PTGS2 mRNA]

PMID:18841975 PMID:37471654

NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978

G

v-rel reticuloendotheliosis viral oncogene homolog A (avian)

multiple interactions

sinapinic acid inhibits the reaction [Lipopolysaccharides affects the localization of RELA protein]

NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158

G

ring finger protein 145

decreases expression

sinapinic acid analog results in decreased expression of RNF145 mRNA

NCBI chr11:44,409,486...44,456,347
Ensembl chr11:44,409,791...44,456,347

G

sema domain, immunoglobulin domain (Ig), and GPI membrane anchor, (semaphorin) 7A

decreases expression

sinapinic acid analog results in decreased expression of SEMA7A mRNA

NCBI chr 9:57,846,879...57,870,148
Ensembl chr 9:57,847,395...57,870,148

G

sestrin 2

increases expression

sinapinic acid analog results in increased expression of SESN2 mRNA

NCBI chr 4:132,220,115...132,237,767
Ensembl chr 4:132,219,343...132,237,812

G

solute carrier family 1 (glutamate/neutral amino acid transporter), member 4

increases expression

sinapinic acid analog results in increased expression of SLC1A4 mRNA

NCBI chr11:20,252,180...20,282,713
Ensembl chr11:20,252,180...20,282,713

G

solute carrier family 7 (cationic amino acid transporter, y+ system), member 11

increases expression

sinapinic acid analog results in increased expression of SLC7A11 mRNA

NCBI chr 3:50,319,385...50,403,947
Ensembl chr 3:49,846,975...50,398,063

G

sushi, nidogen and EGF-like domains 1

decreases expression

sinapinic acid analog results in decreased expression of SNED1 mRNA

NCBI chr 1:93,163,563...93,228,787
Ensembl chr 1:93,163,563...93,228,787

G

SRC kinase signaling inhibitor 1

decreases expression

sinapinic acid analog results in decreased expression of SRCIN1 mRNA

NCBI chr11:97,400,166...97,466,059
Ensembl chr11:97,400,166...97,467,012

G

StAR related lipid transfer domain containing 4

increases expression

sinapinic acid analog results in increased expression of STARD4 mRNA

NCBI chr18:33,332,191...33,346,937
Ensembl chr18:33,332,408...33,346,915

G

thromboxane A2 receptor

decreases expression

sinapinic acid analog results in decreased expression of TBXA2R mRNA

NCBI chr10:81,164,102...81,171,008
Ensembl chr10:81,164,565...81,171,006

G

tumor necrosis factor

multiple interactions

sinapinic acid inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]
2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [sinapinic acid inhibits the reaction [Cisplatin results in increased expression of TNF protein]]; sinapinic acid inhibits the reaction [Cisplatin results in increased expression of TNF protein]; sinapinic acid inhibits the reaction [lead acetate results in increased expression of TNF mRNA]; sinapinic acid inhibits the reaction [Methotrexate results in increased expression of TNF protein]

PMID:18841975 PMID:32742113 PMID:33720507 PMID:37471654

NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983

G

tribbles pseudokinase 3

increases expression

sinapinic acid analog results in increased expression of TRIB3 mRNA

NCBI chr 2:152,179,345...152,185,980
Ensembl chr 2:152,179,342...152,185,952

tetrahydrocurcumin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

S-adenosylhomocysteine hydrolase

affects expression

Tetrahydrocurcumin affects expression of protein and mRNA in ischemia/reperfusion CBS+/- mice

RGD

NCBI chr 2:154,901,230...154,916,417
Ensembl chr 2:154,901,230...154,916,417

G

amyloid beta precursor protein

multiple interactions

tetrahydrocurcumin inhibits the reaction [APP protein binds to APP protein]

NCBI chr16:84,751,236...84,972,187
Ensembl chr16:84,746,573...84,970,654

G

catalase

multiple interactions
affects expression

tetrahydrocurcumin inhibits the reaction [Chloroquine results in decreased activity of CAT protein]; tetrahydrocurcumin inhibits the reaction [sodium arsenite results in decreased activity of CAT protein]; tetrahydrocurcumin inhibits the reaction [Vincristine results in decreased expression of CAT protein]
Tetrahydrocurcumin affects expression of protein and mRNA in ischemia/reperfusion CBS+/- mice
tetrahydrocurcumin inhibits the reaction [Acetaminophen results in decreased expression of CAT protein]

CTD
RGD

PMID:17076682 PMID:25869292 PMID:26102012 PMID:30423402 PMID:22212488

NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505

G

cytochrome P450, family 1, subfamily a, polypeptide 2

multiple interactions

tetrahydrocurcumin inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of CYP1A2 mRNA]

NCBI chr 9:57,584,220...57,590,938
Ensembl chr 9:57,584,220...57,590,986

G

cytochrome P450, family 1, subfamily b, polypeptide 1

multiple interactions

tetrahydrocurcumin inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of CYP1B1 mRNA]; tetrahydrocurcumin inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of CYP1B1 protein]

NCBI chr17:80,014,369...80,022,490
Ensembl chr17:80,008,966...80,022,490

G

cytochrome P450, family 2, subfamily b, polypeptide 10

decreases expression

tetrahydrocurcumin results in decreased expression of CYP2B10 mRNA

NCBI chr 7:25,597,083...25,626,049
Ensembl chr 7:25,597,045...25,626,049

G

cytochrome P450, family 2, subfamily b, polypeptide 9

decreases expression

tetrahydrocurcumin results in decreased expression of CYP2B9 mRNA

NCBI chr 7:25,872,775...25,910,086
Ensembl chr 7:25,872,836...25,910,086

G

cytochrome P450, family 2, subfamily c, polypeptide 29

multiple interactions

tetrahydrocurcumin inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of CYP2C29 mRNA]; tetrahydrocurcumin inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of CYP2C29 protein]

NCBI chr19:39,275,541...39,319,157
Ensembl chr19:39,257,849...39,319,157

G

cytochrome P450, family 2, subfamily e, polypeptide 1

multiple interactions

tetrahydrocurcumin inhibits the reaction [Acetaminophen results in increased expression of CYP2E1 mRNA]; tetrahydrocurcumin inhibits the reaction [Acetaminophen results in increased expression of CYP2E1 protein]

NCBI chr 7:140,343,732...140,354,903
Ensembl chr 7:140,343,652...140,354,900

G

cytochrome P450, family 3, subfamily a, polypeptide 11

multiple interactions
increases expression

tetrahydrocurcumin inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of CYP3A11 mRNA]
tetrahydrocurcumin results in increased expression of CYP3A11 protein

NCBI chr 5:145,791,417...145,816,664
Ensembl chr 5:145,791,236...145,816,774

G

glutamic pyruvic transaminase, soluble

multiple interactions

tetrahydrocurcumin inhibits the reaction [Acetaminophen results in increased expression of GPT protein]

NCBI chr15:76,580,926...76,583,875
Ensembl chr15:76,579,916...76,583,886

G

3-hydroxy-3-methylglutaryl-Coenzyme A reductase

multiple interactions

[tetrahydrocurcumin co-treated with Chlorogenic Acid] results in decreased susceptibility to [[Streptozocin co-treated with Niacinamide] results in increased activity of HMGCR protein]; tetrahydrocurcumin results in decreased susceptibility to [[Streptozocin co-treated with Niacinamide] results in increased activity of HMGCR protein]

NCBI chr13:96,785,470...96,807,444
Ensembl chr13:96,785,475...96,807,444

G

lecithin cholesterol acyltransferase

multiple interactions

[tetrahydrocurcumin co-treated with Chlorogenic Acid] results in decreased susceptibility to [[Streptozocin co-treated with Niacinamide] results in decreased activity of LCAT protein]; tetrahydrocurcumin results in decreased susceptibility to [[Streptozocin co-treated with Niacinamide] results in decreased activity of LCAT protein]

NCBI chr 8:106,666,183...106,670,034
Ensembl chr 8:106,666,183...106,670,014

G

lipoprotein lipase

multiple interactions

[tetrahydrocurcumin co-treated with Chlorogenic Acid] results in decreased susceptibility to [[Streptozocin co-treated with Niacinamide] results in decreased activity of LPL protein]; tetrahydrocurcumin results in decreased susceptibility to [[Streptozocin co-treated with Niacinamide] results in decreased activity of LPL protein]

NCBI chr 8:69,333,207...69,359,584
Ensembl chr 8:69,333,143...69,360,100

G

matrix metallopeptidase 2

multiple interactions

tetrahydrocurcumin inhibits the reaction [Cadmium Chloride results in increased expression of MMP2 protein]

NCBI chr 8:93,553,920...93,580,049
Ensembl chr 8:93,553,919...93,580,048

G

matrix metallopeptidase 9

multiple interactions
affects expression

tetrahydrocurcumin inhibits the reaction [Cadmium Chloride results in increased expression of MMP9 protein]
Tetrahydrocurcumin affects expression of protein and mRNA in ischemia/reperfusion CBS+/- mice

CTD
RGD

PMID:25502771 PMID:22212488

NCBI chr 2:164,782,246...164,797,770
Ensembl chr 2:164,782,700...164,797,770

G

methylenetetrahydrofolate reductase

affects expression

Tetrahydrocurcumin affects expression of protein and mRNA in ischemia/reperfusion CBS+/- mice

RGD

NCBI chr 4:148,123,534...148,144,019
Ensembl chr 4:148,123,534...148,144,008

G

neutrophil cytosolic factor 1

affects expression

Tetrahydrocurcumin affects expression of protein and mRNA in ischemia/reperfusion CBS+/- mice

RGD

NCBI chr 5:134,248,907...134,258,479
Ensembl chr 5:134,248,907...134,258,479

G

nitric oxide synthase 2, inducible

multiple interactions

tetrahydrocurcumin inhibits the reaction [Cadmium Chloride results in increased expression of NOS2 protein]

NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080

G

nitric oxide synthase 3, endothelial cell

multiple interactions

tetrahydrocurcumin inhibits the reaction [Cadmium Chloride results in decreased expression of NOS3 protein]

NCBI chr 5:24,569,772...24,589,472
Ensembl chr 5:24,569,808...24,589,472

G

prostaglandin-endoperoxide synthase 2

multiple interactions
decreases expression

tetrahydrocurcumin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]
tetrahydrocurcumin results in decreased expression of PTGS2 mRNA

NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978

G

tumor necrosis factor

multiple interactions

tetrahydrocurcumin inhibits the reaction [Vincristine results in increased expression of TNF protein]

NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983

trans-caffeic acid

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

acetyl-Coenzyme A carboxylase alpha

multiple interactions

caffeic acid results in increased phosphorylation of and results in decreased activity of ACACA protein

NCBI chr11:84,020,461...84,292,477
Ensembl chr11:84,020,498...84,292,477

G

acetylcholinesterase

multiple interactions
decreases activity

caffeic acid inhibits the reaction [Caffeine results in decreased activity of ACHE protein]; Caffeine promotes the reaction [caffeic acid results in decreased activity of ACHE protein]

NCBI chr 5:137,286,516...137,292,728
Ensembl chr 5:137,285,781...137,292,728

G

ATP citrate lyase

multiple interactions

[Metformin co-treated with caffeic acid] results in decreased expression of ACLY protein

NCBI chr11:100,367,178...100,418,826
Ensembl chr11:100,367,179...100,418,826

G

arachidonate 15-lipoxygenase

decreases activity
multiple interactions

caffeic acid results in decreased activity of ALOX15 protein
[caffeic acid results in decreased activity of ALOX15 protein] inhibits the reaction [vorinostat results in increased activity of CASP3 protein]; [caffeic acid results in decreased activity of ALOX15 protein] which results in decreased chemical synthesis of 13-hydroxy-9,11-octadecadienoic acid; [caffeic acid results in decreased activity of ALOX15 protein] which results in increased abundance of 13-hydroxy-9,11-octadecadienoic acid; caffeic acid inhibits the reaction [N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide results in increased activity of ALOX15 protein]

PMID:10904086 PMID:11406566 PMID:15574791

NCBI chr11:70,234,973...70,279,465
Ensembl chr11:70,234,978...70,242,857

G

arachidonate 5-lipoxygenase

multiple interactions

caffeic acid inhibits the reaction [aluminum chloride results in increased expression of ALOX5 mRNA]; caffeic acid inhibits the reaction [aluminum chloride results in increased expression of ALOX5 protein]
caffeic acid inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] affects the localization of ALOX5 protein]; caffeic acid inhibits the reaction [Aluminum results in increased expression of ALOX5 mRNA]; caffeic acid inhibits the reaction [Aluminum results in increased expression of ALOX5 protein]; caffeic acid inhibits the reaction [Hydrogen Peroxide affects the localization of ALOX5 protein]

PMID:18482095 PMID:18951527 PMID:27368151

NCBI chr 6:116,387,030...116,438,139
Ensembl chr 6:116,387,038...116,438,139

G

amyloid beta precursor protein

multiple interactions

caffeic acid inhibits the reaction [aluminum chloride results in increased expression of APP protein modified form]; caffeic acid inhibits the reaction [aluminum chloride results in increased expression of APP protein]

NCBI chr16:84,751,236...84,972,187
Ensembl chr16:84,746,573...84,970,654

G

arginase, liver

decreases activity

caffeic acid results in decreased activity of ARG1 protein

NCBI chr10:24,791,105...24,803,368
Ensembl chr10:24,791,119...24,803,382

G

ATPase, H+ transporting, lysosomal V0 subunit D2

multiple interactions

caffeic acid promotes the reaction [Thapsigargin results in decreased expression of ATP6V0D2 mRNA]

NCBI chr 4:19,876,838...19,922,566
Ensembl chr 4:19,876,841...19,922,605

G

caspase 3

multiple interactions

[caffeic acid results in decreased activity of ALOX15 protein] inhibits the reaction [vorinostat results in increased activity of CASP3 protein]
caffeic acid inhibits the reaction [Valproic Acid results in increased expression of CASP3 protein]

PMID:15574791 PMID:29968957

NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724

G

catalase

multiple interactions
increases activity

caffeic acid inhibits the reaction [Tetradecanoylphorbol Acetate inhibits the reaction [CAT protein results in increased metabolism of Hydrogen Peroxide]]; caffeic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased activity of CAT protein]
caffeic acid results in increased activity of CAT protein
caffeic acid inhibits the reaction [Cisplatin results in decreased activity of CAT protein]; caffeic acid inhibits the reaction [Nickel results in decreased activity of CAT protein]

PMID:18405891 PMID:21640567 PMID:22036979 PMID:27378625

NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505

G

C-C motif chemokine ligand 2

multiple interactions

[Resveratrol co-treated with Catechin co-treated with caffeic acid] results in decreased expression of CCL2 mRNA; caffeic acid inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL2 protein]

PMID:16806235 PMID:31306686

NCBI chr11:81,926,403...81,928,278
Ensembl chr11:81,926,397...81,928,279

G

C-C motif chemokine ligand 3

multiple interactions

[resveratrol co-treated with Catechin co-treated with caffeic acid] results in decreased expression of CCL3 mRNA

NCBI chr11:83,538,669...83,540,204
Ensembl chr11:83,538,670...83,540,181

G

C-C motif chemokine ligand 4

multiple interactions

[resveratrol co-treated with Catechin co-treated with caffeic acid] results in decreased expression of CCL4 mRNA

NCBI chr11:83,553,410...83,555,509
Ensembl chr11:83,553,410...83,555,509

G

C-C motif chemokine receptor 1

multiple interactions

[resveratrol co-treated with Catechin co-treated with caffeic acid] results in decreased expression of CCR1 mRNA

NCBI chr 9:123,762,163...123,768,729
Ensembl chr 9:123,762,161...123,768,729

G

C-C motif chemokine receptor 2

multiple interactions

[resveratrol co-treated with Catechin co-treated with caffeic acid] results in decreased expression of CCR2 mRNA

NCBI chr 9:123,901,954...123,913,594
Ensembl chr 9:123,901,987...123,913,594

G

C-C motif chemokine receptor 4

multiple interactions

[resveratrol co-treated with Catechin co-treated with caffeic acid] results in decreased expression of CCR4 mRNA

NCBI chr 9:114,319,384...114,334,544
Ensembl chr 9:114,319,384...114,333,984

G

CD4 antigen

multiple interactions

[resveratrol co-treated with Catechin co-treated with caffeic acid] results in decreased expression of CD4 mRNA

NCBI chr 6:124,841,656...124,865,210
Ensembl chr 6:124,841,655...124,865,184

G

CD68 antigen

multiple interactions

[resveratrol co-treated with Catechin co-treated with caffeic acid] results in decreased expression of CD68 mRNA

NCBI chr11:69,555,039...69,556,996
Ensembl chr11:69,555,039...69,556,979

G

cell division cycle 20

multiple interactions

[Thapsigargin co-treated with caffeic acid] results in increased expression of CDC20 mRNA

NCBI chr 4:118,290,098...118,294,540
Ensembl chr 4:118,290,098...118,294,549

G

cyclin dependent kinase 2

multiple interactions

caffeic acid promotes the reaction [Thapsigargin results in increased expression of CDK2 mRNA]

NCBI chr10:128,533,807...128,540,920
Ensembl chr10:128,533,808...128,540,900

G

choline acetyltransferase

multiple interactions

caffeic acid inhibits the reaction [aluminum chloride results in decreased expression of CHAT protein]

NCBI chr14:32,130,160...32,187,866
Ensembl chr14:32,130,160...32,187,946

G

catechol-O-methyltransferase

increases methylation

COMT protein results in increased methylation of caffeic acid

NCBI chr16:18,225,632...18,247,006
Ensembl chr16:18,225,636...18,245,602

G

corticotropin releasing hormone

multiple interactions

caffeic acid inhibits the reaction [Malathion results in decreased expression of CRH mRNA]

NCBI chr 3:19,747,565...19,749,560
Ensembl chr 3:19,747,565...19,749,560

G

cardiotrophin 1

multiple interactions

caffeic acid promotes the reaction [Thapsigargin results in decreased expression of CTF1 mRNA]

NCBI chr 7:127,311,872...127,317,360
Ensembl chr 7:127,311,908...127,317,364

G

cathepsin B

multiple interactions

caffeic acid inhibits the reaction [Isoproterenol results in increased activity of CTSB protein]

NCBI chr14:63,359,911...63,383,372
Ensembl chr14:63,359,911...63,383,372

G

cathepsin D

multiple interactions

caffeic acid inhibits the reaction [Isoproterenol affects the activity of CTSD protein]

NCBI chr 7:141,929,647...141,941,564
Ensembl chr 7:141,929,648...141,941,775

G

C-X-C motif chemokine ligand 15

multiple interactions

caffeic acid inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL8 mRNA]; caffeic acid inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL8 protein]

NCBI chr 5:90,942,393...90,950,926
Ensembl chr 5:90,942,393...90,950,926

G

C-X-C motif chemokine ligand 2

multiple interactions

caffeic acid promotes the reaction [Thapsigargin results in decreased expression of CXCL2 mRNA]

NCBI chr 5:91,051,758...91,053,797
Ensembl chr 5:91,051,730...91,053,797

G

cytochrome P450, family 2, subfamily e, polypeptide 1

multiple interactions

caffeic acid inhibits the reaction [CYP2E1 protein results in increased reduction of tirapazamine]

NCBI chr 7:140,343,732...140,354,903
Ensembl chr 7:140,343,652...140,354,900

G

death-associated protein

multiple interactions

caffeic acid promotes the reaction [Thapsigargin results in decreased expression of DAP mRNA]

NCBI chr15:31,224,531...31,274,484
Ensembl chr15:31,224,460...31,274,487

G

DnaJ heat shock protein family (Hsp40) member B11

multiple interactions

caffeic acid promotes the reaction [Thapsigargin results in decreased expression of DNAJB11 mRNA]

NCBI chr16:22,676,595...22,698,384
Ensembl chr16:22,676,595...22,698,384

G

dihydropyrimidinase-like 4

multiple interactions

caffeic acid promotes the reaction [Thapsigargin results in increased expression of DPYSL4 mRNA]

NCBI chr 7:138,665,917...138,681,711
Ensembl chr 7:138,665,917...138,682,620

G

endothelin 1

multiple interactions

[resveratrol co-treated with Catechin co-treated with caffeic acid] results in decreased expression of EDN1 mRNA

NCBI chr13:42,454,952...42,461,466
Ensembl chr13:42,454,952...42,461,466

G

early growth response 1

multiple interactions

caffeic acid affects the reaction [Acetaminophen results in increased expression of and affects the localization of EGR1 protein]; caffeic acid inhibits the reaction [Acetaminophen results in increased expression of EGR1 mRNA]

NCBI chr18:34,994,260...34,998,009
Ensembl chr18:34,992,876...34,998,037

G

engulfment and cell motility 2

multiple interactions

caffeic acid promotes the reaction [Thapsigargin results in decreased expression of ELMO2 mRNA]

NCBI chr 2:165,129,951...165,168,421
Ensembl chr 2:165,129,951...165,168,399

G

Ets2 repressor factor

multiple interactions

caffeic acid promotes the reaction [Thapsigargin results in increased expression of ERF mRNA]

NCBI chr 7:24,941,985...24,950,522
Ensembl chr 7:24,941,986...24,950,186

G

coagulation factor III

multiple interactions

caffeic acid inhibits the reaction [Acetaminophen results in increased expression of F3 protein]

NCBI chr 3:121,517,186...121,528,701
Ensembl chr 3:121,517,186...121,528,697

G

fatty acid synthase

decreases expression
multiple interactions

caffeic acid results in decreased expression of FASN mRNA
[Metformin co-treated with caffeic acid] results in decreased expression of FASN protein

PMID:21870829 PMID:28576465

NCBI chr11:120,696,784...120,715,992
Ensembl chr11:120,696,672...120,715,373

G

fibronectin leucine rich transmembrane protein 2

multiple interactions

caffeic acid promotes the reaction [Thapsigargin results in decreased expression of FLRT2 mRNA]

NCBI chr12:95,658,780...95,751,989
Ensembl chr12:95,659,000...95,751,989

G

FMS-like tyrosine kinase 4

multiple interactions

caffeic acid promotes the reaction [Thapsigargin results in decreased expression of FLT4 mRNA]

NCBI chr11:49,500,506...49,543,566
Ensembl chr11:49,500,090...49,543,566

G

glucose-6-phosphate dehydrogenase X-linked

decreases activity

caffeic acid results in decreased activity of G6PD protein

NCBI chr X:73,453,089...73,472,486
Ensembl chr X:73,453,089...73,472,800

G

growth arrest and DNA-damage-inducible 45 alpha

multiple interactions

caffeic acid inhibits the reaction [Acetaminophen results in increased expression of GADD45A mRNA]; caffeic acid inhibits the reaction [Acetaminophen results in increased expression of GADD45A protein]

NCBI chr 6:67,012,080...67,014,391
Ensembl chr 6:67,012,080...67,014,441

G

galactosidase, beta 1

multiple interactions

caffeic acid inhibits the reaction [Isoproterenol affects the activity of GLB1 protein]

NCBI chr 9:114,230,146...114,303,447
Ensembl chr 9:114,230,144...114,303,966

G

glutaminase

increases expression

caffeic acid results in increased expression of GLS protein

NCBI chr 1:52,202,608...52,274,168
Ensembl chr 1:52,202,607...52,272,391

G

glutamic-oxaloacetic transaminase 1, soluble

multiple interactions

caffeic acid inhibits the reaction [tert-Butylhydroperoxide results in increased activity of GOT1 protein]

NCBI chr19:43,488,191...43,514,743
Ensembl chr19:43,488,191...43,513,044

G

glutamic pyruvic transaminase, soluble

multiple interactions

caffeic acid inhibits the reaction [tert-Butylhydroperoxide results in increased activity of GPT protein]
caffeic acid inhibits the reaction [Acetaminophen results in increased activity of GPT protein]

PMID:15212457 PMID:27720869

NCBI chr15:76,580,926...76,583,875
Ensembl chr15:76,579,916...76,583,886

G

glutathione reductase

multiple interactions

caffeic acid inhibits the reaction [Cisplatin results in decreased activity of GSR protein]
caffeic acid inhibits the reaction [Tetradecanoylphorbol Acetate inhibits the reaction [GSR protein results in increased oxidation of NADP]]; caffeic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased activity of GSR protein]
caffeic acid promotes the reaction [Thapsigargin results in decreased expression of GSR mRNA]

PMID:19442820 PMID:21640567 PMID:22036979

NCBI chr 8:34,143,266...34,188,190
Ensembl chr 8:34,142,551...34,188,191

G

glutathione S-transferase, mu 1

decreases activity

caffeic acid results in decreased activity of GSTM1 protein

NCBI chr 3:107,919,566...107,925,289
Ensembl chr 3:107,919,571...107,925,289

G

glutathione S-transferase, mu 2

decreases activity

caffeic acid results in decreased activity of GSTM2 protein

NCBI chr 3:107,889,018...107,893,736
Ensembl chr 3:107,889,018...107,893,769

G

glutathione S-transferase, pi 1

decreases activity

caffeic acid results in decreased activity of GSTP1 protein

NCBI chr19:4,085,411...4,087,912
Ensembl chr19:4,085,407...4,087,985

G

glucuronidase, beta

multiple interactions

caffeic acid inhibits the reaction [Isoproterenol results in increased activity of GUSB protein]

NCBI chr 5:130,011,278...130,031,890
Ensembl chr 5:130,017,852...130,031,890

G

hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)

multiple interactions

caffeic acid inhibits the reaction [Cisplatin results in decreased activity of H6PD protein]

NCBI chr 4:150,063,931...150,093,480
Ensembl chr 4:150,063,932...150,093,480

G

hepatitis A virus cellular receptor 2

multiple interactions

[resveratrol co-treated with Catechin co-treated with caffeic acid] results in decreased expression of HAVCR2 mRNA

NCBI chr11:46,345,758...46,372,082
Ensembl chr11:46,345,762...46,372,082

G

hes family bHLH transcription factor 1

multiple interactions

caffeic acid inhibits the reaction [Valproic Acid results in increased expression of HES1 mRNA]

NCBI chr16:29,883,259...29,886,614
Ensembl chr16:29,883,202...29,886,614

G

holocarboxylase synthetase (biotin- [propriony-Coenzyme A-carboxylase (ATP-hydrolysing)] ligase)

decreases activity

caffeic acid results in decreased activity of HLCS protein

NCBI chr16:93,930,054...94,116,098
Ensembl chr16:93,929,741...94,114,430

G

3-hydroxy-3-methylglutaryl-Coenzyme A reductase

decreases expression

caffeic acid results in decreased expression of HMGCR mRNA

NCBI chr13:96,785,470...96,807,444
Ensembl chr13:96,785,475...96,807,444

G

heat shock protein 90, beta (Grp94), member 1

multiple interactions

caffeic acid promotes the reaction [Thapsigargin results in decreased expression of HSP90B1 mRNA]

NCBI chr10:86,526,705...86,541,308
Ensembl chr10:86,526,073...86,541,373

G

heat shock protein 1 (chaperonin 10)

multiple interactions

caffeic acid promotes the reaction [Thapsigargin results in increased expression of HSPE1 mRNA]

NCBI chr 1:55,127,307...55,130,476
Ensembl chr 1:55,127,291...55,130,466

G

interferon gamma

increases expression
multiple interactions

caffeic acid results in increased expression of IFNG protein
caffeic acid inhibits the reaction [Valproic Acid results in increased expression of IFNG protein]

PMID:27378625 PMID:29968957

NCBI chr10:118,276,951...118,281,799
Ensembl chr10:118,276,951...118,281,797

G

interleukin 10

decreases expression

caffeic acid results in decreased expression of IL10 protein

NCBI chr 1:130,947,459...130,952,707
Ensembl chr 1:130,947,582...130,952,711

G

interleukin 1 beta

multiple interactions

caffeic acid inhibits the reaction [Aluminum results in increased expression of IL1B protein]
caffeic acid inhibits the reaction [Acetaminophen results in increased expression of IL1B protein]

PMID:27368151 PMID:27720869

NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059

G

interleukin 2

increases expression

caffeic acid results in increased expression of IL2 protein

NCBI chr 3:37,174,862...37,180,103
Ensembl chr 3:37,174,672...37,180,108

G

interleukin 21 receptor

multiple interactions

caffeic acid promotes the reaction [Thapsigargin results in decreased expression of IL21R mRNA]

NCBI chr 7:125,202,424...125,232,742
Ensembl chr 7:125,202,601...125,232,742

G

interleukin 4

decreases expression

caffeic acid results in decreased expression of IL4 protein

NCBI chr11:53,503,287...53,509,492
Ensembl chr11:53,493,809...53,509,496

G

interleukin 6

increases expression
multiple interactions

caffeic acid results in increased expression of IL6 mRNA
caffeic acid inhibits the reaction [Aluminum results in increased expression of IL6 protein]
caffeic acid inhibits the reaction [Acetaminophen results in increased expression of IL6 protein]

PMID:21870829 PMID:27368151 PMID:27720869

NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979

G

kinesin family member 15

multiple interactions

[Thapsigargin co-treated with caffeic acid] results in increased expression of KIF15 mRNA

NCBI chr 9:122,780,146...122,847,798
Ensembl chr 9:122,780,111...122,847,798

G

kinesin family member 20B

multiple interactions

caffeic acid promotes the reaction [Thapsigargin results in increased expression of KIF20B mRNA]

NCBI chr19:34,899,735...34,953,150
Ensembl chr19:34,899,761...34,953,145

G

kinesin family member 2C

multiple interactions

caffeic acid inhibits the reaction [Thapsigargin results in increased expression of KIF2C mRNA]

NCBI chr 4:117,016,830...117,039,821
Ensembl chr 4:117,016,836...117,039,836

G

lactate dehydrogenase A

multiple interactions

caffeic acid inhibits the reaction [Isoproterenol results in increased expression of LDHA protein]

NCBI chr 7:46,491,698...46,505,051
Ensembl chr 7:46,490,899...46,505,051

G

lactate dehydrogenase B

multiple interactions

caffeic acid inhibits the reaction [Isoproterenol results in increased expression of LDHB protein]

NCBI chr 6:142,435,975...142,453,683
Ensembl chr 6:142,435,975...142,453,683

G

monoamine oxidase A

decreases activity

caffeic acid results in decreased activity of MAOA protein

NCBI chr X:16,485,937...16,554,051
Ensembl chr X:16,485,937...16,554,057

G

monoamine oxidase B

decreases activity

caffeic acid results in decreased activity of MAOB protein

NCBI chr X:16,575,520...16,683,605
Ensembl chr X:16,575,521...16,683,605

G

mitogen-activated protein kinase kinase 5

multiple interactions

[Thapsigargin co-treated with caffeic acid] results in decreased expression of MAP2K5 mRNA

NCBI chr 9:63,071,050...63,288,964
Ensembl chr 9:63,071,050...63,285,184

G

mitogen-activated protein kinase 1

multiple interactions

caffeic acid inhibits the reaction [Acetaminophen results in increased phosphorylation of MAPK1 protein]

NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317

G

mitogen-activated protein kinase 3

multiple interactions

caffeic acid inhibits the reaction [Acetaminophen results in increased phosphorylation of MAPK3 protein]

NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991

G

mitofusin 1

multiple interactions

caffeic acid promotes the reaction [Thapsigargin results in decreased expression of MFN1 mRNA]

NCBI chr 3:32,583,594...32,633,384
Ensembl chr 3:32,583,614...32,633,388

G

microsomal glutathione S-transferase 1

increases activity

caffeic acid results in increased activity of MGST1 protein

NCBI chr 6:138,117,525...138,133,753
Ensembl chr 6:138,117,314...138,133,753

G

myeloperoxidase

multiple interactions
decreases activity

caffeic acid inhibits the reaction [Tetradecanoylphorbol Acetate promotes the reaction [MPO protein results in increased metabolism of Hydrogen Peroxide]]; caffeic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of MPO protein]
caffeic acid inhibits the reaction [Ethanol results in increased activity of MPO protein]; NG-Nitroarginine Methyl Ester inhibits the reaction [caffeic acid inhibits the reaction [Ethanol results in increased activity of MPO protein]]
caffeic acid results in decreased activity of MPO protein

PMID:22036979 PMID:24060682 PMID:33301711

NCBI chr11:87,684,610...87,695,238
Ensembl chr11:87,684,407...87,695,239

G

mitochondrial ribosomal protein L45

multiple interactions

caffeic acid promotes the reaction [Thapsigargin results in decreased expression of MRPL45 mRNA]

NCBI chr11:97,205,749...97,220,746
Ensembl chr11:97,206,542...97,220,746

G

mitochondrial ribosome recycling factor

multiple interactions

caffeic acid promotes the reaction [Thapsigargin results in decreased expression of MRRF mRNA]

NCBI chr 2:36,025,672...36,080,296
Ensembl chr 2:36,026,401...36,080,659

G

cytochrome c oxidase II, mitochondrial

multiple interactions

[caffeic acid co-treated with Zymosan] results in increased expression of COX2 protein; caffeic acid inhibits the reaction [Zymosan results in increased expression of COX2 protein]

NCBI chr MT:7,013...7,696
Ensembl chr MT:7,013...7,696

G

Norrie disease (pseudoglioma) (human)

increases expression

caffeic acid results in increased expression of NDP mRNA

NCBI chr X:16,751,760...16,778,013
Ensembl chr X:16,751,760...16,778,013

G

nitric oxide synthase 2, inducible

multiple interactions

caffeic acid inhibits the reaction [Valproic Acid results in increased expression of NOS2 protein]
caffeic acid inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]

PMID:29968957 PMID:31306686

NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080

G

nitric oxide synthase 3, endothelial cell

increases expression

caffeic acid results in increased expression of NOS3 mRNA

NCBI chr 5:24,569,772...24,589,472
Ensembl chr 5:24,569,808...24,589,472

G

notch 1

multiple interactions

caffeic acid inhibits the reaction [Valproic Acid results in increased expression of NOTCH1 mRNA]

NCBI chr 2:26,347,914...26,393,834
Ensembl chr 2:26,347,915...26,406,675

G

5' nucleotidase, ecto

decreases activity
multiple interactions

caffeic acid results in decreased activity of NT5E protein
caffeic acid inhibits the reaction [Caffeine results in decreased activity of NT5E protein]; Caffeine promotes the reaction [caffeic acid results in decreased activity of NT5E protein]

NCBI chr 9:88,209,662...88,254,142
Ensembl chr 9:88,209,250...88,254,145

G

programmed cell death 10

multiple interactions

caffeic acid promotes the reaction [Thapsigargin results in decreased expression of PDCD10 mRNA]

NCBI chr 3:75,423,797...75,464,159
Ensembl chr 3:75,423,797...75,464,163

G

phosphogluconate dehydrogenase

decreases activity

caffeic acid results in decreased activity of PGD protein

NCBI chr 4:149,234,448...149,251,162
Ensembl chr 4:149,234,448...149,251,228

G

phosphoinositide-3-kinase regulatory subunit 1

increases expression

caffeic acid results in increased expression of PIK3R1 mRNA

NCBI chr13:101,817,269...101,904,725
Ensembl chr13:101,817,071...101,904,725

G

polo like kinase 1

multiple interactions

[Thapsigargin co-treated with caffeic acid] results in increased expression of PLK1 mRNA

NCBI chr 7:121,758,658...121,769,107
Ensembl chr 7:121,758,662...121,769,096

G

polo like kinase 4

multiple interactions

caffeic acid promotes the reaction [Thapsigargin results in increased expression of PLK4 mRNA]

NCBI chr 3:40,754,463...40,771,318
Ensembl chr 3:40,754,454...40,771,318

G

peroxisome proliferator activated receptor gamma

increases expression

caffeic acid results in increased expression of PPARG mRNA

NCBI chr 6:115,337,828...115,467,365
Ensembl chr 6:115,337,912...115,467,360

G

peroxiredoxin 5

multiple interactions

caffeic acid promotes the reaction [Thapsigargin results in decreased expression of PRDX5 mRNA]

NCBI chr19:6,884,065...6,887,474
Ensembl chr19:6,884,065...6,887,474

G

prostaglandin-endoperoxide synthase 2

multiple interactions

caffeic acid inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]; caffeic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 protein]
caffeic acid promotes the reaction [Thapsigargin results in decreased expression of PTGS2 mRNA]

PMID:19442820 PMID:22036979 PMID:31306686

NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978

G

pentraxin related gene

multiple interactions

caffeic acid promotes the reaction [Thapsigargin results in decreased expression of PTX3 mRNA]

NCBI chr 3:66,127,308...66,133,227
Ensembl chr 3:66,127,331...66,133,226

G

v-raf-leukemia viral oncogene 1

multiple interactions

caffeic acid inhibits the reaction [Acetaminophen results in increased phosphorylation of RAF1 protein]

NCBI chr 6:115,595,530...115,653,596
Ensembl chr 6:115,595,028...115,653,596

G

v-rel reticuloendotheliosis viral oncogene homolog A (avian)

multiple interactions

caffeic acid inhibits the reaction [Valproic Acid results in increased expression of RELA protein]

NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158

G

stearoyl-Coenzyme A desaturase 2

multiple interactions

[Metformin co-treated with caffeic acid] results in decreased expression of SCD1 protein

NCBI chr19:44,282,115...44,295,303
Ensembl chr19:44,282,113...44,295,303

G

serine (or cysteine) peptidase inhibitor, clade E, member 1

multiple interactions

caffeic acid inhibits the reaction [Acetaminophen results in increased expression of SERPINE1 protein]

NCBI chr 5:137,090,358...137,101,126
Ensembl chr 5:137,090,358...137,101,122

G

sideroflexin 4

multiple interactions

caffeic acid promotes the reaction [Thapsigargin results in decreased expression of SFXN4 mRNA]

NCBI chr19:60,824,747...60,850,222
Ensembl chr19:60,825,715...60,849,917

G

solute carrier family 2 (facilitated glucose transporter), member 2

increases expression

caffeic acid results in increased expression of SLC2A2 mRNA

NCBI chr 3:28,752,052...28,782,510
Ensembl chr 3:28,752,052...28,785,508

G

solute carrier family 2 (facilitated glucose transporter), member 4

increases expression

caffeic acid results in increased expression of SLC2A4 mRNA

NCBI chr11:69,833,112...69,839,040
Ensembl chr11:69,833,365...69,839,014

G

solute carrier family 5 (sodium/glucose cotransporter), member 1

increases expression

caffeic acid results in increased expression of SLC5A1 mRNA

NCBI chr 5:33,261,563...33,320,043
Ensembl chr 5:33,261,563...33,320,214

G

synuclein, alpha

multiple interactions

caffeic acid inhibits the reaction [SNCA protein binds to SNCA protein]

NCBI chr 6:60,708,557...60,806,839
Ensembl chr 6:60,708,559...60,806,839

G

sterol regulatory element binding transcription factor 1

multiple interactions

[Metformin co-treated with caffeic acid] results in decreased expression of SREBF1 protein

NCBI chr11:60,089,910...60,113,407
Ensembl chr11:60,089,915...60,113,407

G

serine/threonine kinase 32A

multiple interactions

[Thapsigargin co-treated with caffeic acid] results in decreased expression of STK32A mRNA

NCBI chr18:43,340,762...43,450,546
Ensembl chr18:43,340,648...43,451,747

G

sulfotransferase family 1A, phenol-preferring, member 1

increases sulfation

SULT1A2 protein results in increased sulfation of caffeic acid

NCBI chr 7:126,272,042...126,289,615
Ensembl chr 7:126,272,037...126,275,604

G

sulfotransferase family, cytosolic, 1C, member 2

increases sulfation

SULT1C2 protein results in increased sulfation of caffeic acid

NCBI chr17:54,136,665...54,152,986
Ensembl chr17:54,136,665...54,153,367

G

tumor necrosis factor

multiple interactions
increases expression

caffeic acid inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; caffeic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of TNF protein]
caffeic acid inhibits the reaction [Aluminum results in increased expression of TNF protein]; caffeic acid inhibits the reaction [Valproic Acid results in increased expression of TNF protein]
caffeic acid results in increased expression of TNF mRNA

PMID:21870829 PMID:22036979 PMID:27368151 PMID:29968957 PMID:31306686

NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983

G

transformation related protein 53

affects expression
multiple interactions

caffeic acid affects the expression of TP53 protein
caffeic acid promotes the reaction [Thapsigargin results in decreased expression of TP53 mRNA]

PMID:11522280 PMID:19442820

NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699

G

tyrosinase

increases oxidation
multiple interactions

TYR protein results in increased oxidation of caffeic acid
[TYR protein results in increased oxidation of caffeic acid] which results in decreased abundance of Glutathione

NCBI chr 7:87,073,979...87,142,637
Ensembl chr 7:87,073,979...87,142,720

G

ubiquitin-conjugating enzyme E2C

multiple interactions

caffeic acid promotes the reaction [Thapsigargin results in increased expression of UBE2C mRNA]

NCBI chr 2:164,611,849...164,614,822
Ensembl chr 2:164,611,818...164,620,742

G

UDP glucuronosyltransferase 1 family, polypeptide A1

decreases activity

caffeic acid results in decreased activity of UGT1A1 protein

NCBI chr 1:88,139,681...88,147,724
Ensembl chr 1:88,139,681...88,146,719

G

UDP glycosyltransferase 1 family, polypeptide A10

increases glucuronidation
decreases activity

UGT1A10 protein results in increased glucuronidation of caffeic acid
caffeic acid results in decreased activity of UGT1A10 protein

PMID:15117964 PMID:35868516

NCBI chr 1:87,983,133...88,147,724
Ensembl chr 1:87,983,110...88,146,726

G

UDP glucuronosyltransferase 1 family, polypeptide A2

increases glucuronidation
decreases activity

UGT1A3 protein results in increased glucuronidation of caffeic acid
caffeic acid results in decreased activity of UGT1A3 protein

PMID:15117964 PMID:35868516

NCBI chr 1:88,128,333...88,147,724
Ensembl chr 1:88,128,323...88,146,719

G

UDP glucuronosyltransferase 1 family, polypeptide A6B

decreases activity

caffeic acid results in decreased activity of UGT1A6 protein

NCBI chr 1:88,030,979...88,146,720
Ensembl chr 1:88,030,974...88,146,725

G

UDP glucuronosyltransferase 1 family, polypeptide A9

decreases activity

caffeic acid results in decreased activity of UGT1A9 protein

NCBI chr 1:87,998,501...88,147,724
Ensembl chr 1:87,998,522...88,146,719

G

UDP glucuronosyltransferase 2 family, polypeptide B1

decreases activity

caffeic acid results in decreased activity of UGT2B17 protein

NCBI chr 5:87,064,498...87,074,362
Ensembl chr 5:87,064,497...87,074,389

G

UDP glucuronosyltransferase 2 family, polypeptide B34

decreases activity

caffeic acid results in decreased activity of UGT2B7 protein

NCBI chr 5:87,037,613...87,054,805
Ensembl chr 5:87,037,626...87,054,796

G

vascular endothelial growth factor A

decreases secretion

caffeic acid results in decreased secretion of VEGFA protein

NCBI chr17:46,327,919...46,343,303
Ensembl chr17:46,327,919...46,343,295

G

xanthine dehydrogenase

multiple interactions

caffeic acid inhibits the reaction [Tetradecanoylphorbol Acetate promotes the reaction [XDH protein results in increased chemical synthesis of Uric Acid]]; caffeic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of XDH protein]

NCBI chr17:74,190,890...74,257,191
Ensembl chr17:74,190,890...74,257,191

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	22194
chemical entity	22193
atom	22186
nonmetal atom	22071
carbon atom	21846
organic molecular entity	21846
olefinic compound	17093
cinnamic acids	2516
hydroxycinnamic acid	1366
(+)-3-O-feruloylcassine	0
(-)-bornyl ferulate	0
(-)-bornyl-caffeate	4
(2-\{[3-(3,4-dihydroxy-5-methoxyphenyl)prop-2-enoyl]oxy\}ethyl)trimethylazanium	0
(2-\{[3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxy\}ethyl)trimethylazanium	0
(2E)-3-(2,4-dihydroxy-5-methoxyphenyl)prop-2-enoic acid	0
(2E,2'E)-N,N'-(butane-1,4-diyl)bis[3-(4-hydroxyphenyl)-N-(3-\{[(2E)-3-(4-hydroxyphenyl)prop-2-enoyl]amino\}propyl)prop-2-enamide]	0
(2R)-3-(3,4-dihydroxyphenyl)-2-[3-(3,4-dihydroxyphenyl)-1-oxoprop-2-enoxy]propanoic acid	0
(2s,3s)-2-\{[(2e)-3-(3,4-Dihydroxyphenyl)-2-propenoyl]oxy\}-3,4-dihydroxy-2-methylbutanoic acid	0
(3,4,5,6-tetrahydroxyoxan-2-yl)methyl (2E)-3-(3,4-dihydroxyphenyl)prop-2-enoate	0
(3,4,5,6-tetrahydroxyoxan-2-yl)methyl 3-(4-hydroxy-3-methoxyphenyl)prop-2-enoate	0
(6-\{[3,4-dihydroxy-2,5-bis(hydroxymethyl)oxolan-2-yl]oxy\}-3,4,5-trihydroxyoxan-2-yl)methyl (2E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoate	0
(7E)-3-(4-buta-2,3-dienyloxy-3-methoxy-phenyl)-acrylic acid methyl ester	0
(7E)-3-[4-(4-buta-2,3-dienyloxy-benzyloxy)-3-methoxy-phenyl]-acrylic acid methyl ester	0
(E)-3,4,5-Trimethoxycinnamic acid	0
(E)-N-(4-Acetamidobutyl)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enamide	0
(R)-2-Feruloyl-1-(4-Hydroxyphenyl)-1,2-ethanediol	0
(z)-3-(4-hydroxyphenyl)-n-[4-[[(e)-3-(4-hydroxyphenyl)prop-2-enoyl]amino]butyl]prop-2-enamide	0
1,2-Disinapoylgentiobiose	0
1,26-Hexacosanediol diferulate	0
1,26-Hexacosanediyl (2E,2'E)bis[3-(3,4-dihydroxyphenyl)acrylate]	0
1,28-Dicaffeoyloctacosanediol	0
1,28-Octacosanediol diferulate	0
1,5-Bis(4-hydroxy-3-methoxyphenyl)-1,4-pentadien-3-one	0
1-(3,4-Dihydroxyphenyl)-1-decene-3,5-dione	0
1-(4-Hydroxy-3-methoxyphenyl)-5-(4-hydroxyphenyl)-1,4-pentadien-3-one	0
1-(4-Hydroxyphenyl)-1-decene-3,5-dione	0
1-(4-hydroxy-3-methoxyphenyl)-5-(4-hydroxyphenyl)-1,4-pentadiene-3-one	0
1-Caffeoyl-4-deoxyquinic acid	0
1-Dehydro-[6]-gingerdione	0
1-O-2'-Hydroxy-4'-methoxycinnamoyl-b-D-glucose	0
1-O-Caffeoyl-(b-D-glucose 6-O-sulfate)	0
1-O-Caffeoylglucose	0
1-O-Feruloylglucose	0
1-O-Sinapoylglucose	0
1-O-p-Coumaroyl-(b-D-glucose 6-O-sulfate)	0
1-O-p-Coumaroyl-beta-D-glucose	0
1-hydroxy-4-(4-hydroxy-3-methoxyphenyl)but-3-en-2-one	0
2'-(E)-Feruloyl-3-(arabinosylxylose)	0
2,3-dihydroxycinnamic acid +	0
2,5-Dimethoxycinnamic acid	0
2,6-Dihydroxy-4,5-dimethyl-3-(3-oxo-1-butenyl) benzoic acid	0
2-(1,2-dihydroxyethyl)-3-[(E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxy-4-hydroxy-3,4-dihydro-2H-pyran-6-carboxylic acid	0
2-Amino-6-[3-(3,4-dihydroxyphenyl)prop-2-enoylamino]hexanoic acid	0
2-Feruloyl-1,2'-disinapoylgentiobiose	0
2-Feruloyl-1-sinapoylgentiobiose	0
2-Hydroxy-3-methylbenzalpyruvate	0
2-Hydroxy-4-hydroxymethylbenzalpyruvate	0
2-Isopropyl-3-methoxycinnamic acid	0
2-O-Caffeoyltartronic acid	0
2-O-Feruloyltartronic acid	0
2-O-sinapoyl malate	0
2-Propenoic acid, 3-(3-methoxyphenyl)-	0
2-[3-(4-Hydroxy-3,5-dimethoxyphenyl)prop-2-enoyloxy]butanedioic acid	0
2-\{[(2E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxy\}-3-[4-hydroxy-3-(sulfooxy)phenyl]propanoic acid	0
2-\{[3,4-dihydroxy-5,6-bis(\{[(2E)-3-(4-hydroxy-3,5-dimethoxyphenyl)prop-2-enoyl]oxy\})oxan-2-yl]methoxy\}-4,5-dihydroxy-6-(hydroxymethyl)oxan-3-yl (2E)-3-(4-hydroxy-3,5-dimethoxyphenyl)prop-2-enoate	0
2-\{[3-(4-hydroxy-3-methoxyphenyl)prop-2-enoyl]oxy\}-3-(sulfooxy)butanedioic acid	0
2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethyl-2-propenamide	0
2-cyano-3-(3,4-dihydroxyphenyl)-2-propenamide	0
2-cyano-3-(3,4-dihydroxyphenyl)-2-propenoic acid 2-thiophen-2-ylethyl ester	0
2-cyano-3-(3,4-dihydroxyphenyl)-2-propenoic acid 3-phenylprop-2-enyl ester	0
2-cyano-3-(3,4-dihydroxyphenyl)-N-(3-phenylpropyl)-2-propenamide	0
2-cyano-3-(3,4-dihydroxyphenyl)-N-(4-phenylbutyl)-2-propenamide	0
2-cyano-3-(3,4-dihydroxyphenyl)-N-(phenylmethyl)-2-propenamide	0
2-cyano-3-(3,4-dihydroxyphenyl)-N-[(1R)-1-phenylethyl]-2-propenamide	0
2-cyano-3-(3,4-dihydroxyphenyl)-N-[(1S)-1-phenylethyl]prop-2-enamide	0
2-cyano-3-(3,4-dihydroxyphenyl)-N-phenyl-2-propenamide	0
2-cyano-3-(3,4-dimethoxyphenyl)acrylic acid	0
2-cyano-3-(3-hydroxyphenyl)-2-propenoic acid	0
2-cyano-3-(4-hydroxyphenyl)acrylamide	0
2-cyano-3-[3-ethoxy-4-hydroxy-5-[(phenylthio)methyl]phenyl]-2-propenamide	0
2-cyano-3-[4-[2-(2,4-dimethylanilino)-2-oxoethoxy]-3-methoxyphenyl]-2-propenoic acid ethyl ester	0
2-cyano-3-[4-hydroxy-3,5-di(propan-2-yl)phenyl]-N-(3-phenylpropyl)-2-propenamide	0
2-cyano-N-[3-[[2-cyano-3-(3,4-dihydroxyphenyl)-1-oxoprop-2-enyl]amino]propyl]-3-(3,4-dihydroxyphenyl)-2-propenamide	0
2-cyano-N-[4-[[4-[[2-cyano-3-(3,4-dihydroxyphenyl)-1-oxoprop-2-enyl]amino]cyclohexyl]methyl]cyclohexyl]-3-(3,4-dihydroxyphenyl)-2-propenamide	0
2-hydroxy-3-[(E)-3-(3-hydroxy-4-methoxyphenyl)prop-2-enoyl]oxypropanoic acid	0
2-hydroxymethyl-3-hydroxy-(E)-cinnamic acid	0
3',6-Disinapoyl sucrose	0
3,4,5-trihydroxy-2-[hydroxy(3,4,5-trihydroxyoxan-2-yl)methyl]-6-[(2E)-3-(4-hydroxyphenyl)prop-2-enoyl]-4-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]cyclohex-2-en-1-one	0
3,4,5-trihydroxy-6-\{[(2E)-3-(2,4,5-trihydroxyphenyl)prop-2-enoyl]oxy\}oxane-2-carboxylic acid	0
3,4-Dicaffeoyl-1,5-quinolactone	0
3,4-Dihydroxycinnamoyl-(Z)-2-(3,4-dihydroxyphenyl)ethenol	0
3,4-dihydroxy-5-\{[(2E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoyl]oxy\}cyclohex-1-ene-1-carboxylic acid	0
3,4-dihydroxy-5-prenylcinnamic acid	0
3,5-dihydroxy-2-[(2E)-3-(4-hydroxyphenyl)prop-2-enoyl]cyclohexa-2,5-diene-1,4-dione	0
3,5-dihydroxycinnamic acid	0
3,6'-Disinapoyl sucrose	0
3-(1,3-benzodioxol-5-yl)-2-propenoic acid [2-(cyclopropylamino)-2-oxoethyl] ester	0
3-(2,5-dihydroxyphenyl)-2-propenoic acid methyl ester	0
3-(2-Hydroxy-3-methoxyphenyl)-2-propenoic acid	0
3-(2-methoxyphenyl)-2-propenoic acid	0
3-(3,4,5-trimethoxyphenyl)-2-propenoic acid [2-oxo-2-(2-phenylethylamino)ethyl] ester	0
3-(3,4-dihydroxyphenyl)-2-propenoic acid 2-phenylethyl ester	0
3-(3,4-dimethoxyphenyl)-2-propenoic acid [2-(2-furanylmethylamino)-2-oxoethyl] ester	0
3-(3,4-dimethoxyphenyl)prop-2-enoic acid	0
3-(3,5-Dihydroxyphenyl)-2-propenoic acid	0
3-(3-bromo-4-hydroxy-5-methoxyphenyl)-2-cyano-N-(2-methoxyethyl)-2-propenamide	0
3-(3-chloro-4-hydroxy-5-methoxyphenyl)-2-cyano-N-propan-2-yl-2-propenamide	0
3-(3-hydroxy-4,5-dimethoxyphenyl)prop-2-enoic acid	0
3-(3-hydroxyphenyl)-1-(3-pyridinyl)-2-propen-1-one	0
3-(3-methoxyphenyl)-2-propenoic acid [2-(2-furanylmethylamino)-2-oxoethyl] ester	0
3-(3-methoxyphenyl)-2-propenoic acid [2-[2-(1-cyclohexenyl)ethylamino]-2-oxoethyl] ester	0
3-(3-methoxyphenyl)-2-propenoic acid [2-oxo-2-[4-(1-pyrrolidinylsulfonyl)anilino]ethyl] ester	0
3-(4-hydroxy-3-methoxyphenyl)-2-propenoic acid [2-[2-[(4-chlorophenyl)thio]anilino]-2-oxoethyl] ester	0
3-(4-hydroxy-3-methoxyphenyl)-2-propenoic acid [2-[4-[2-furanyl(oxo)methyl]-1-piperazinyl]-2-oxoethyl] ester	0
3-(4-hydroxy-3-methoxyphenyl)prop-2-enoic acid	0
3-(5-bromo-2-methoxyphenyl)-N-(3-pyridinylmethyl)-2-propenamide	0
3-(6-hydroxy-2,3,4-trimethoxyphenyl)prop-2-enoic acid	0
3-Caffeoyl-1,5-quinolactone	0
3-Demethylsimmondsin 2'-(Z)-ferulate	0
3-Feruloyl-1,5-quinolactone	0
3-Hydroxy 4-Methoxy Cinnamic acid	0
3-Hydroxycinnamate sulfate	0
3-Methoxycinnamic acid	0
3-O-Caffeoylshikimic acid	0
3-O-Methylrosmarinic acid	0
3-O-beta-D-glucosyl-trans-caffeic acid	0
3-O-caffeoyl-2-(2-butyl)-2-hydroxybutanedioic acid	0
3-O-caffeoyl-2-(2-propyl)-2-hydroxybutanedioic acid	0
3-[3-(2-hydroxyethylsulfamoyl)-4,5-dimethoxyphenyl]-2-propenoic acid	0
3-[3-(sulfooxy)phenyl]prop-2-enoic acid	0
3-[3-[(1,3-benzothiazol-2-ylthio)methyl]-4-hydroxy-5-methoxyphenyl]-2-cyano-2-propenamide	0
3-[4-(difluoromethoxy)-3-methoxyphenyl]-2-propenoic acid [2-(4-amino-1,3-dimethyl-2,6-dioxo-5-pyrimidinyl)-2-oxoethyl] ester	0
3-[4-hydroxy-3-(4-hydroxy-3-methylbut-2-en-1-yl)phenyl]prop-2-enoic acid	0
3-\{4-hydroxy-3-[(2E)-4-hydroxy-3-methylbut-2-en-1-yl]phenyl\}prop-2-enoic acid	0
4,5-dihydroxy-6-(hydroxymethyl)-2-[(3,4,5,6-tetrahydroxyoxan-2-yl)methoxy]oxan-3-yl 3-(4-hydroxy-3-methoxyphenyl)prop-2-enoate	0
4-Caffeoyl-1,5-quinolactone	0
4-Coumaroyl-2-hydroxyputrescine	0
4-Coumaroylputrescine	0
4-Demethylsimmondsin 2'-(E)-ferulate	0
4-Demethylsimmondsin 2'-ferulate	0
4-Feruloyl-1,5-quinolactone	0
4-O-Caffeoylshikimic acid	0
4-O-beta-D-glucosyl-trans-caffeic acid	0
4-O-caffeoyl-2-C-methyl-D-erythronic acid	0
5''-dihydrohygromycin A	0
5'-((Z)-Feruloyl) 3-(2'-methylarabinosylxylose)	0
5-\{[(2E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxy\}-3-hydroxy-4-(sulfooxy)cyclohex-1-ene-1-carboxylic acid	0
5-hydroxyferulic acid +	0
6'-O-Caffeoylcatalpol	0
6,6'-Di-O-caffeoylcatalpol	0
6-(\{4,5-dihydroxy-2-[hydroxy(\{2,3,4-trihydroxy-6-oxo-3-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]cyclohexa-1,4-dien-1-yl\})methyl]oxan-3-yl\}oxy)-3,4,5-trihydroxyoxane-2-carboxylic acid	0
6-Caffeoylsucrose	0
6-O-feruloylcatalpol	0
6-\{[3-(3,4-dihydroxy-5-methoxyphenyl)prop-2-enoyl]oxy\}-3,4,5-trihydroxyoxane-2-carboxylic acid	0
6-hydroxyferulic acid + 122 Da	0
6-hydroxyferulic acid derivative	0
6-hydroxyferulic acid-4-O-hexoside	0
6-hydroxyferulic acid-6-O-hexoside	0
6-hydroxyferuloyl hexose	0
6-hydroxyferuloyl hexose hexoside	0
Altenuic acid IV	0
Avenanthramide A	0
Caffeic Acid-13C9	0
Caffeic acid 4-O-sulfate	0
Caffeic acid ethyl ester	0
Caffeoyl C1-glucuronide	0
Caffeoylisocitric acid	0
Caffeoylmalic acid	0
Caffeoyltryptamine	0
Caftaric acid	0
Calceolarioside B	0
Calebin A	0
Capillartemisin A	0
Capillartemisin B	0
Carthamin	0
Carthamone	0
Cartormin	0
Cinnamamide, p-hydroxy-N-(p-hydroxyphenethyl)-	0
Cis-Caffeoyl tartaric acid	0
Cis-Entacapone	0
Coumaroyl feruloylputrescine	0
Dattelic acid	0
Dehydrozingerone	0
Di-4-coumaroylputrescine	0
Dicaffeoylputrescine	0
Diferuloylputrescine	2
Docosyl trans-ferulate	0
Eicosanyl caffeate	0
Erythrinasinate A	0
Feruloyl C1-glucuronide	0
Feruloyl glucose	0
Feruloyl-2-hydroxyputrescine	0
Feruloylcholine	0
Forsythiaside	6
Fukinolic acid	0
Glomeratose A	0
Grandidentoside	0
Gravolenic acid	0
Hellicoside	0
Hexadecyl ferulate	0
Interfungin B	0
Interfungin C	0
Isoacteoside	0
Isoferulic acid 3-sulfate	0
Isoferuloyl C1-glucuronide	0
Isopulegone caffeate	0
Magnoloside A	0
Methyl 3-(3,4,5-trimethoxyphenyl)prop-2-enoate	0
Methyl rosmarinate	0
Methyl-sinapate	0
Methylenedioxycinnamic acid	0
N-(2,3-dihydro-1,4-benzodioxin-6-yl)-3-(2-methoxyphenyl)-2-propenamide	0
N-(2,3-dihydro-1,4-benzodioxin-6-yl)-3-(3-methoxyphenyl)-2-propenamide	0
N-(2-chloro-3-pyridinyl)-3-(2-methoxyphenyl)-2-propenamide	0
N-(4-Aminobutyl)-3-(3,4-dihydroxyphenyl)prop-2-enamide	0
N-(4-Aminobutyl)-3-(4-hydroxyphenyl)prop-2-enamide	0
N-cis-Feruloyltyramine	0
N-trans-feruloyl-3-methoxytyramine +	0
N-trans-sinapoyltyramine	0
N1,N10-Diferuloylspermidine	0
N1,N5,N10-Tri-(hydroxyferuloyl)-spermidine	0
N1,N5,N10-Triferuloyl spermidine	0
N1,N5,N10-Tris-trans-p-coumaroylspermine	0
NAC-Diketide	0
NP02140176-46	0
Nb-Feruloyltryptamine	0
Nb-p-Coumaroyltryptamine	0
Nitecapone	1
Orobanchoside	0
Pestalotiopisorin A	0
Phaseolic acid	0
Phellibaumin D	0
Phellibaumin E	0
Plantamajoside	13
Prenyl caffeate	0
Pyrrolidine, 1-(m-methoxycinnamoyl)-	0
Salvianolic acid D	0
Sibiricose A1	0
Sibiricose A5	0
Sibiricose A6	0
Simmondsin 2'-ferulate	0
Sinapic acid acetate	0
Sinapinic acid-O-sulphate	0
Sinapoyl glucose	0
Sinapoyl malate	0
Sinapoylputrescine	0
Sinapoylspermine	0
Sordariolone	0
Sphagnum acid	0
Streptoarylpyrazole A	0
Subaphyllin	0
Tenuifoliside A	0
Trans-2, 3, 4-Trimethoxycinnamate	0
Vinyl caffeate	0
[(2R,3S,4S,5R,6R)-3,4,5-trihydroxy-6-(2-hydroxycyclohexyl)oxyoxan-2-yl]methyl (E)-3-(3,4-dihydroxyphenyl)prop-2-enoate	0
[(2S,3S,4R,5R)-4-Hydroxy-2,5-bis(hydroxymethyl)-2-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxolan-3-yl] (E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoate	0
[(2r,3s,4s,5r,6r)-3,4,5-trihydroxy-6-[2-(3-hydroxy-5-oxooxolan-3-yl)propoxy]oxan-2-yl]methyl (e)-3-(3,4-dihydroxyphenyl)prop-2-enoate	0
[10]-Dehydrogingerdione	0
[3,4,5-Trihydroxy-6-[2-(3-hydroxy-5-oxooxolan-3-yl)propoxy]oxan-2-yl]methyl 3-(3,4-dihydroxyphenyl)prop-2-enoate	0
[6-[2-(3,4-Dihydroxyphenyl)ethoxy]-4,5-dihydroxy-2-(hydroxymethyl)oxan-3-yl] 3-(3,4-dihydroxyphenyl)prop-2-enoate	0
[6-[3,4-Dihydroxy-2,5-bis(hydroxymethyl)oxolan-2-yl]oxy-3,4,5-trihydroxyoxan-2-yl]methyl 3-(4-hydroxy-3,5-dimethoxyphenyl)prop-2-enoate	0
[6]-Dehydrogingerdione	0
[6]-Dehydroshogaol	0
[8]-Dehydrogingerdione	0
[8]-Dehydroshogaol	0
beta-(3,4-dihydroxyphenyl)ethyl-3-O-E-caffeoyl-O-[beta-D-apiofuranosyl-(1->2)]-beta-D-glucopyranoside	0
beta-(3,4-dihydroxyphenyl)ethyl-4-O-E-caffeoyl-O-[beta-D-apiofuranosyl-(1->2)]-beta-D-glucopyranoside	0
beta-(3,4-dihydroxyphenyl)ethyl-6-O-E-caffeoyl-O-[beta-D-apiofuranosyl-(1->2)]-beta-D-glucopyranoside	0
beta-(4-hydroxyphenyl)ethyl-3-O-E-caffeoyl-O-[beta-D-apiofuranosyl-(1->2)]-beta-D-glucopyranoside	0
beta-D-Glucopyranose, 1-O-[(2E)-3-(2-hydroxyphenyl)-1-oxo-2-propen-1-yl]-	0
beta-D-Glucosyl-2-hydroxycinnamate	0
beta-Hydroxyacteoside	0
caffeic acid +	591
calceolarioside A	0
cinametic acid	0
feruloyl-3-methoxytyramine glycoside	0
feruloylglycoside	0
hygromycin A	0
lignin cw compound-1003	0
lignin cw compound-196	0
lignin cw compound-3022	0
lignin cw compound-3023	0
lignin cw compound-3024	0
methyl (Z)-3-(3,4-dihydroxyphenyl)-2-formamidoacrylate	0
methyl sinapate	0
minecoside	0
monohydroxycinnamic acid +	1029
p-Coumaroyl-D-glucose	0
p-Hydroxyphenethyl trans-ferulate	0
p-coumaroylputrescine	0
poacic acid	0
scopoletin pentosyl hexoside 6-hydroxyferulic acid	0
sinapic acid 4-o-sulfate	0
trans-Caffeic acid [apiosyl-(1->6)-glucosyl] ester	0
trans-N-p-coumaroyl tyramine	0
verminoside	0
Path 2
Term	Annotations
CHEBI ontology	22194
subatomic particle	22186
composite particle	22186
hadron	22186
baryon	22186
nucleon	22186
atomic nucleus	22186
atom	22186
main group element atom	22120
p-block element atom	22120
carbon group element atom	21920
carbon atom	21846
organic molecular entity	21846
heteroorganic entity	21500
organochalcogen compound	20983
organooxygen compound	20824
carbon oxoacid	19606
carboxylic acid	19602
monocarboxylic acid	18969
alpha,beta-unsaturated monocarboxylic acid	13648
cinnamic acids	2516
hydroxycinnamic acid	1366
(+)-3-O-feruloylcassine	0
(-)-bornyl ferulate	0
(-)-bornyl-caffeate	4
(2-\{[3-(3,4-dihydroxy-5-methoxyphenyl)prop-2-enoyl]oxy\}ethyl)trimethylazanium	0
(2-\{[3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxy\}ethyl)trimethylazanium	0
(2E)-3-(2,4-dihydroxy-5-methoxyphenyl)prop-2-enoic acid	0
(2E,2'E)-N,N'-(butane-1,4-diyl)bis[3-(4-hydroxyphenyl)-N-(3-\{[(2E)-3-(4-hydroxyphenyl)prop-2-enoyl]amino\}propyl)prop-2-enamide]	0
(2R)-3-(3,4-dihydroxyphenyl)-2-[3-(3,4-dihydroxyphenyl)-1-oxoprop-2-enoxy]propanoic acid	0
(2s,3s)-2-\{[(2e)-3-(3,4-Dihydroxyphenyl)-2-propenoyl]oxy\}-3,4-dihydroxy-2-methylbutanoic acid	0
(3,4,5,6-tetrahydroxyoxan-2-yl)methyl (2E)-3-(3,4-dihydroxyphenyl)prop-2-enoate	0
(3,4,5,6-tetrahydroxyoxan-2-yl)methyl 3-(4-hydroxy-3-methoxyphenyl)prop-2-enoate	0
(6-\{[3,4-dihydroxy-2,5-bis(hydroxymethyl)oxolan-2-yl]oxy\}-3,4,5-trihydroxyoxan-2-yl)methyl (2E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoate	0
(7E)-3-(4-buta-2,3-dienyloxy-3-methoxy-phenyl)-acrylic acid methyl ester	0
(7E)-3-[4-(4-buta-2,3-dienyloxy-benzyloxy)-3-methoxy-phenyl]-acrylic acid methyl ester	0
(E)-3,4,5-Trimethoxycinnamic acid	0
(E)-N-(4-Acetamidobutyl)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enamide	0
(R)-2-Feruloyl-1-(4-Hydroxyphenyl)-1,2-ethanediol	0
(z)-3-(4-hydroxyphenyl)-n-[4-[[(e)-3-(4-hydroxyphenyl)prop-2-enoyl]amino]butyl]prop-2-enamide	0
1,2-Disinapoylgentiobiose	0
1,26-Hexacosanediol diferulate	0
1,26-Hexacosanediyl (2E,2'E)bis[3-(3,4-dihydroxyphenyl)acrylate]	0
1,28-Dicaffeoyloctacosanediol	0
1,28-Octacosanediol diferulate	0
1,5-Bis(4-hydroxy-3-methoxyphenyl)-1,4-pentadien-3-one	0
1-(3,4-Dihydroxyphenyl)-1-decene-3,5-dione	0
1-(4-Hydroxy-3-methoxyphenyl)-5-(4-hydroxyphenyl)-1,4-pentadien-3-one	0
1-(4-Hydroxyphenyl)-1-decene-3,5-dione	0
1-(4-hydroxy-3-methoxyphenyl)-5-(4-hydroxyphenyl)-1,4-pentadiene-3-one	0
1-Caffeoyl-4-deoxyquinic acid	0
1-Dehydro-[6]-gingerdione	0
1-O-2'-Hydroxy-4'-methoxycinnamoyl-b-D-glucose	0
1-O-Caffeoyl-(b-D-glucose 6-O-sulfate)	0
1-O-Caffeoylglucose	0
1-O-Feruloylglucose	0
1-O-Sinapoylglucose	0
1-O-p-Coumaroyl-(b-D-glucose 6-O-sulfate)	0
1-O-p-Coumaroyl-beta-D-glucose	0
1-hydroxy-4-(4-hydroxy-3-methoxyphenyl)but-3-en-2-one	0
2'-(E)-Feruloyl-3-(arabinosylxylose)	0
2,3-dihydroxycinnamic acid +	0
2,5-Dimethoxycinnamic acid	0
2,6-Dihydroxy-4,5-dimethyl-3-(3-oxo-1-butenyl) benzoic acid	0
2-(1,2-dihydroxyethyl)-3-[(E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxy-4-hydroxy-3,4-dihydro-2H-pyran-6-carboxylic acid	0
2-Amino-6-[3-(3,4-dihydroxyphenyl)prop-2-enoylamino]hexanoic acid	0
2-Feruloyl-1,2'-disinapoylgentiobiose	0
2-Feruloyl-1-sinapoylgentiobiose	0
2-Hydroxy-3-methylbenzalpyruvate	0
2-Hydroxy-4-hydroxymethylbenzalpyruvate	0
2-Isopropyl-3-methoxycinnamic acid	0
2-O-Caffeoyltartronic acid	0
2-O-Feruloyltartronic acid	0
2-O-sinapoyl malate	0
2-Propenoic acid, 3-(3-methoxyphenyl)-	0
2-[3-(4-Hydroxy-3,5-dimethoxyphenyl)prop-2-enoyloxy]butanedioic acid	0
2-\{[(2E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxy\}-3-[4-hydroxy-3-(sulfooxy)phenyl]propanoic acid	0
2-\{[3,4-dihydroxy-5,6-bis(\{[(2E)-3-(4-hydroxy-3,5-dimethoxyphenyl)prop-2-enoyl]oxy\})oxan-2-yl]methoxy\}-4,5-dihydroxy-6-(hydroxymethyl)oxan-3-yl (2E)-3-(4-hydroxy-3,5-dimethoxyphenyl)prop-2-enoate	0
2-\{[3-(4-hydroxy-3-methoxyphenyl)prop-2-enoyl]oxy\}-3-(sulfooxy)butanedioic acid	0
2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethyl-2-propenamide	0
2-cyano-3-(3,4-dihydroxyphenyl)-2-propenamide	0
2-cyano-3-(3,4-dihydroxyphenyl)-2-propenoic acid 2-thiophen-2-ylethyl ester	0
2-cyano-3-(3,4-dihydroxyphenyl)-2-propenoic acid 3-phenylprop-2-enyl ester	0
2-cyano-3-(3,4-dihydroxyphenyl)-N-(3-phenylpropyl)-2-propenamide	0
2-cyano-3-(3,4-dihydroxyphenyl)-N-(4-phenylbutyl)-2-propenamide	0
2-cyano-3-(3,4-dihydroxyphenyl)-N-(phenylmethyl)-2-propenamide	0
2-cyano-3-(3,4-dihydroxyphenyl)-N-[(1R)-1-phenylethyl]-2-propenamide	0
2-cyano-3-(3,4-dihydroxyphenyl)-N-[(1S)-1-phenylethyl]prop-2-enamide	0
2-cyano-3-(3,4-dihydroxyphenyl)-N-phenyl-2-propenamide	0
2-cyano-3-(3,4-dimethoxyphenyl)acrylic acid	0
2-cyano-3-(3-hydroxyphenyl)-2-propenoic acid	0
2-cyano-3-(4-hydroxyphenyl)acrylamide	0
2-cyano-3-[3-ethoxy-4-hydroxy-5-[(phenylthio)methyl]phenyl]-2-propenamide	0
2-cyano-3-[4-[2-(2,4-dimethylanilino)-2-oxoethoxy]-3-methoxyphenyl]-2-propenoic acid ethyl ester	0
2-cyano-3-[4-hydroxy-3,5-di(propan-2-yl)phenyl]-N-(3-phenylpropyl)-2-propenamide	0
2-cyano-N-[3-[[2-cyano-3-(3,4-dihydroxyphenyl)-1-oxoprop-2-enyl]amino]propyl]-3-(3,4-dihydroxyphenyl)-2-propenamide	0
2-cyano-N-[4-[[4-[[2-cyano-3-(3,4-dihydroxyphenyl)-1-oxoprop-2-enyl]amino]cyclohexyl]methyl]cyclohexyl]-3-(3,4-dihydroxyphenyl)-2-propenamide	0
2-hydroxy-3-[(E)-3-(3-hydroxy-4-methoxyphenyl)prop-2-enoyl]oxypropanoic acid	0
2-hydroxymethyl-3-hydroxy-(E)-cinnamic acid	0
3',6-Disinapoyl sucrose	0
3,4,5-trihydroxy-2-[hydroxy(3,4,5-trihydroxyoxan-2-yl)methyl]-6-[(2E)-3-(4-hydroxyphenyl)prop-2-enoyl]-4-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]cyclohex-2-en-1-one	0
3,4,5-trihydroxy-6-\{[(2E)-3-(2,4,5-trihydroxyphenyl)prop-2-enoyl]oxy\}oxane-2-carboxylic acid	0
3,4-Dicaffeoyl-1,5-quinolactone	0
3,4-Dihydroxycinnamoyl-(Z)-2-(3,4-dihydroxyphenyl)ethenol	0
3,4-dihydroxy-5-\{[(2E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoyl]oxy\}cyclohex-1-ene-1-carboxylic acid	0
3,4-dihydroxy-5-prenylcinnamic acid	0
3,5-dihydroxy-2-[(2E)-3-(4-hydroxyphenyl)prop-2-enoyl]cyclohexa-2,5-diene-1,4-dione	0
3,5-dihydroxycinnamic acid	0
3,6'-Disinapoyl sucrose	0
3-(1,3-benzodioxol-5-yl)-2-propenoic acid [2-(cyclopropylamino)-2-oxoethyl] ester	0
3-(2,5-dihydroxyphenyl)-2-propenoic acid methyl ester	0
3-(2-Hydroxy-3-methoxyphenyl)-2-propenoic acid	0
3-(2-methoxyphenyl)-2-propenoic acid	0
3-(3,4,5-trimethoxyphenyl)-2-propenoic acid [2-oxo-2-(2-phenylethylamino)ethyl] ester	0
3-(3,4-dihydroxyphenyl)-2-propenoic acid 2-phenylethyl ester	0
3-(3,4-dimethoxyphenyl)-2-propenoic acid [2-(2-furanylmethylamino)-2-oxoethyl] ester	0
3-(3,4-dimethoxyphenyl)prop-2-enoic acid	0
3-(3,5-Dihydroxyphenyl)-2-propenoic acid	0
3-(3-bromo-4-hydroxy-5-methoxyphenyl)-2-cyano-N-(2-methoxyethyl)-2-propenamide	0
3-(3-chloro-4-hydroxy-5-methoxyphenyl)-2-cyano-N-propan-2-yl-2-propenamide	0
3-(3-hydroxy-4,5-dimethoxyphenyl)prop-2-enoic acid	0
3-(3-hydroxyphenyl)-1-(3-pyridinyl)-2-propen-1-one	0
3-(3-methoxyphenyl)-2-propenoic acid [2-(2-furanylmethylamino)-2-oxoethyl] ester	0
3-(3-methoxyphenyl)-2-propenoic acid [2-[2-(1-cyclohexenyl)ethylamino]-2-oxoethyl] ester	0
3-(3-methoxyphenyl)-2-propenoic acid [2-oxo-2-[4-(1-pyrrolidinylsulfonyl)anilino]ethyl] ester	0
3-(4-hydroxy-3-methoxyphenyl)-2-propenoic acid [2-[2-[(4-chlorophenyl)thio]anilino]-2-oxoethyl] ester	0
3-(4-hydroxy-3-methoxyphenyl)-2-propenoic acid [2-[4-[2-furanyl(oxo)methyl]-1-piperazinyl]-2-oxoethyl] ester	0
3-(4-hydroxy-3-methoxyphenyl)prop-2-enoic acid	0
3-(5-bromo-2-methoxyphenyl)-N-(3-pyridinylmethyl)-2-propenamide	0
3-(6-hydroxy-2,3,4-trimethoxyphenyl)prop-2-enoic acid	0
3-Caffeoyl-1,5-quinolactone	0
3-Demethylsimmondsin 2'-(Z)-ferulate	0
3-Feruloyl-1,5-quinolactone	0
3-Hydroxy 4-Methoxy Cinnamic acid	0
3-Hydroxycinnamate sulfate	0
3-Methoxycinnamic acid	0
3-O-Caffeoylshikimic acid	0
3-O-Methylrosmarinic acid	0
3-O-beta-D-glucosyl-trans-caffeic acid	0
3-O-caffeoyl-2-(2-butyl)-2-hydroxybutanedioic acid	0
3-O-caffeoyl-2-(2-propyl)-2-hydroxybutanedioic acid	0
3-[3-(2-hydroxyethylsulfamoyl)-4,5-dimethoxyphenyl]-2-propenoic acid	0
3-[3-(sulfooxy)phenyl]prop-2-enoic acid	0
3-[3-[(1,3-benzothiazol-2-ylthio)methyl]-4-hydroxy-5-methoxyphenyl]-2-cyano-2-propenamide	0
3-[4-(difluoromethoxy)-3-methoxyphenyl]-2-propenoic acid [2-(4-amino-1,3-dimethyl-2,6-dioxo-5-pyrimidinyl)-2-oxoethyl] ester	0
3-[4-hydroxy-3-(4-hydroxy-3-methylbut-2-en-1-yl)phenyl]prop-2-enoic acid	0
3-\{4-hydroxy-3-[(2E)-4-hydroxy-3-methylbut-2-en-1-yl]phenyl\}prop-2-enoic acid	0
4,5-dihydroxy-6-(hydroxymethyl)-2-[(3,4,5,6-tetrahydroxyoxan-2-yl)methoxy]oxan-3-yl 3-(4-hydroxy-3-methoxyphenyl)prop-2-enoate	0
4-Caffeoyl-1,5-quinolactone	0
4-Coumaroyl-2-hydroxyputrescine	0
4-Coumaroylputrescine	0
4-Demethylsimmondsin 2'-(E)-ferulate	0
4-Demethylsimmondsin 2'-ferulate	0
4-Feruloyl-1,5-quinolactone	0
4-O-Caffeoylshikimic acid	0
4-O-beta-D-glucosyl-trans-caffeic acid	0
4-O-caffeoyl-2-C-methyl-D-erythronic acid	0
5''-dihydrohygromycin A	0
5'-((Z)-Feruloyl) 3-(2'-methylarabinosylxylose)	0
5-\{[(2E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxy\}-3-hydroxy-4-(sulfooxy)cyclohex-1-ene-1-carboxylic acid	0
5-hydroxyferulic acid +	0
6'-O-Caffeoylcatalpol	0
6,6'-Di-O-caffeoylcatalpol	0
6-(\{4,5-dihydroxy-2-[hydroxy(\{2,3,4-trihydroxy-6-oxo-3-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]cyclohexa-1,4-dien-1-yl\})methyl]oxan-3-yl\}oxy)-3,4,5-trihydroxyoxane-2-carboxylic acid	0
6-Caffeoylsucrose	0
6-O-feruloylcatalpol	0
6-\{[3-(3,4-dihydroxy-5-methoxyphenyl)prop-2-enoyl]oxy\}-3,4,5-trihydroxyoxane-2-carboxylic acid	0
6-hydroxyferulic acid + 122 Da	0
6-hydroxyferulic acid derivative	0
6-hydroxyferulic acid-4-O-hexoside	0
6-hydroxyferulic acid-6-O-hexoside	0
6-hydroxyferuloyl hexose	0
6-hydroxyferuloyl hexose hexoside	0
Altenuic acid IV	0
Avenanthramide A	0
Caffeic Acid-13C9	0
Caffeic acid 4-O-sulfate	0
Caffeic acid ethyl ester	0
Caffeoyl C1-glucuronide	0
Caffeoylisocitric acid	0
Caffeoylmalic acid	0
Caffeoyltryptamine	0
Caftaric acid	0
Calceolarioside B	0
Calebin A	0
Capillartemisin A	0
Capillartemisin B	0
Carthamin	0
Carthamone	0
Cartormin	0
Cinnamamide, p-hydroxy-N-(p-hydroxyphenethyl)-	0
Cis-Caffeoyl tartaric acid	0
Cis-Entacapone	0
Coumaroyl feruloylputrescine	0
Dattelic acid	0
Dehydrozingerone	0
Di-4-coumaroylputrescine	0
Dicaffeoylputrescine	0
Diferuloylputrescine	2
Docosyl trans-ferulate	0
Eicosanyl caffeate	0
Erythrinasinate A	0
Feruloyl C1-glucuronide	0
Feruloyl glucose	0
Feruloyl-2-hydroxyputrescine	0
Feruloylcholine	0
Forsythiaside	6
Fukinolic acid	0
Glomeratose A	0
Grandidentoside	0
Gravolenic acid	0
Hellicoside	0
Hexadecyl ferulate	0
Interfungin B	0
Interfungin C	0
Isoacteoside	0
Isoferulic acid 3-sulfate	0
Isoferuloyl C1-glucuronide	0
Isopulegone caffeate	0
Magnoloside A	0
Methyl 3-(3,4,5-trimethoxyphenyl)prop-2-enoate	0
Methyl rosmarinate	0
Methyl-sinapate	0
Methylenedioxycinnamic acid	0
N-(2,3-dihydro-1,4-benzodioxin-6-yl)-3-(2-methoxyphenyl)-2-propenamide	0
N-(2,3-dihydro-1,4-benzodioxin-6-yl)-3-(3-methoxyphenyl)-2-propenamide	0
N-(2-chloro-3-pyridinyl)-3-(2-methoxyphenyl)-2-propenamide	0
N-(4-Aminobutyl)-3-(3,4-dihydroxyphenyl)prop-2-enamide	0
N-(4-Aminobutyl)-3-(4-hydroxyphenyl)prop-2-enamide	0
N-cis-Feruloyltyramine	0
N-trans-feruloyl-3-methoxytyramine +	0
N-trans-sinapoyltyramine	0
N1,N10-Diferuloylspermidine	0
N1,N5,N10-Tri-(hydroxyferuloyl)-spermidine	0
N1,N5,N10-Triferuloyl spermidine	0
N1,N5,N10-Tris-trans-p-coumaroylspermine	0
NAC-Diketide	0
NP02140176-46	0
Nb-Feruloyltryptamine	0
Nb-p-Coumaroyltryptamine	0
Nitecapone	1
Orobanchoside	0
Pestalotiopisorin A	0
Phaseolic acid	0
Phellibaumin D	0
Phellibaumin E	0
Plantamajoside	13
Prenyl caffeate	0
Pyrrolidine, 1-(m-methoxycinnamoyl)-	0
Salvianolic acid D	0
Sibiricose A1	0
Sibiricose A5	0
Sibiricose A6	0
Simmondsin 2'-ferulate	0
Sinapic acid acetate	0
Sinapinic acid-O-sulphate	0
Sinapoyl glucose	0
Sinapoyl malate	0
Sinapoylputrescine	0
Sinapoylspermine	0
Sordariolone	0
Sphagnum acid	0
Streptoarylpyrazole A	0
Subaphyllin	0
Tenuifoliside A	0
Trans-2, 3, 4-Trimethoxycinnamate	0
Vinyl caffeate	0
[(2R,3S,4S,5R,6R)-3,4,5-trihydroxy-6-(2-hydroxycyclohexyl)oxyoxan-2-yl]methyl (E)-3-(3,4-dihydroxyphenyl)prop-2-enoate	0
[(2S,3S,4R,5R)-4-Hydroxy-2,5-bis(hydroxymethyl)-2-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxolan-3-yl] (E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoate	0
[(2r,3s,4s,5r,6r)-3,4,5-trihydroxy-6-[2-(3-hydroxy-5-oxooxolan-3-yl)propoxy]oxan-2-yl]methyl (e)-3-(3,4-dihydroxyphenyl)prop-2-enoate	0
[10]-Dehydrogingerdione	0
[3,4,5-Trihydroxy-6-[2-(3-hydroxy-5-oxooxolan-3-yl)propoxy]oxan-2-yl]methyl 3-(3,4-dihydroxyphenyl)prop-2-enoate	0
[6-[2-(3,4-Dihydroxyphenyl)ethoxy]-4,5-dihydroxy-2-(hydroxymethyl)oxan-3-yl] 3-(3,4-dihydroxyphenyl)prop-2-enoate	0
[6-[3,4-Dihydroxy-2,5-bis(hydroxymethyl)oxolan-2-yl]oxy-3,4,5-trihydroxyoxan-2-yl]methyl 3-(4-hydroxy-3,5-dimethoxyphenyl)prop-2-enoate	0
[6]-Dehydrogingerdione	0
[6]-Dehydroshogaol	0
[8]-Dehydrogingerdione	0
[8]-Dehydroshogaol	0
beta-(3,4-dihydroxyphenyl)ethyl-3-O-E-caffeoyl-O-[beta-D-apiofuranosyl-(1->2)]-beta-D-glucopyranoside	0
beta-(3,4-dihydroxyphenyl)ethyl-4-O-E-caffeoyl-O-[beta-D-apiofuranosyl-(1->2)]-beta-D-glucopyranoside	0
beta-(3,4-dihydroxyphenyl)ethyl-6-O-E-caffeoyl-O-[beta-D-apiofuranosyl-(1->2)]-beta-D-glucopyranoside	0
beta-(4-hydroxyphenyl)ethyl-3-O-E-caffeoyl-O-[beta-D-apiofuranosyl-(1->2)]-beta-D-glucopyranoside	0
beta-D-Glucopyranose, 1-O-[(2E)-3-(2-hydroxyphenyl)-1-oxo-2-propen-1-yl]-	0
beta-D-Glucosyl-2-hydroxycinnamate	0
beta-Hydroxyacteoside	0
caffeic acid +	591
calceolarioside A	0
cinametic acid	0
feruloyl-3-methoxytyramine glycoside	0
feruloylglycoside	0
hygromycin A	0
lignin cw compound-1003	0
lignin cw compound-196	0
lignin cw compound-3022	0
lignin cw compound-3023	0
lignin cw compound-3024	0
methyl (Z)-3-(3,4-dihydroxyphenyl)-2-formamidoacrylate	0
methyl sinapate	0
minecoside	0
monohydroxycinnamic acid +	1029
p-Coumaroyl-D-glucose	0
p-Hydroxyphenethyl trans-ferulate	0
p-coumaroylputrescine	0
poacic acid	0
scopoletin pentosyl hexoside 6-hydroxyferulic acid	0
sinapic acid 4-o-sulfate	0
trans-Caffeic acid [apiosyl-(1->6)-glucosyl] ester	0
trans-N-p-coumaroyl tyramine	0
verminoside	0

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