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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:hydroxamic acid
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Accession:CHEBI:24650 term browser browse the term
Definition:A compound, RkE(=O)lNHOH, derived from an oxoacid RkE(=O)l(OH) (l =/= 0) by replacing -OH with -NHOH, and derivatives thereof. Specific examples of hydroxamic acids are preferably named as N-hydroxy amides.
Synonyms:related_synonym: N-hydroxy amide;   N-hydroxy-amides;   N-hydroxyamide;   N-hydroxyamides;   hydroxamic acids
 alt_id: MESH:D006877
 xref_mesh: MESH:D006877
 cyclic_relationship: is_conjugate_acid_of CHEBI:24648


show annotations for term's descendants           Sort by:
desferrioxamine B term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGT angiotensinogen multiple interactions EXP Deferoxamine inhibits the reaction [AGT protein modified form results in increased susceptibility to Serotonin] CTD PMID:8021468 NCBI chr 4:8,681,192...8,694,059
Ensembl chr 4:8,683,798...8,693,880 		JBrowse link
vorinostat term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CASQ1 calsequestrin 1 decreases expression EXP Vorinostat results in decreased expression of CASQ1 mRNA CTD PMID:27255383 NCBI chr38:22,012,060...22,020,430
Ensembl chr38:22,011,060...22,020,383 		JBrowse link
G HSP70 heat shock protein 70 decreases expression EXP Vorinostat results in decreased expression of HSP70 mRNA CTD PMID:27255383 NCBI chr12:1,285,282...1,287,670 JBrowse link
G TNNI3K TNNI3 interacting kinase decreases expression EXP Vorinostat results in decreased expression of TNNI3K mRNA CTD PMID:27255383 NCBI chr 6:71,825,853...72,107,832
Ensembl chr 6:71,815,734...72,119,476 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 499
    chemical entity 499
      atom 499
        nonmetal atom 492
          nitrogen atom 416
            nitrogen molecular entity 416
              organonitrogen compound 409
                carboxamide 305
                  hydroxamic acid 4
                    (2R)-N-hydroxy-2-[(3S)-3-methyl-3-\{4-[(2-methylquinolin-4-yl)methoxy]phenyl\}-2-oxopyrrolidin-1-yl]propanamide 0
                    (2S)-2-[[(2R)-2-[(1S)-1-hydroxy-2-(hydroxyamino)-2-oxoethyl]-4-methyl-1-oxopentyl]amino]-2-phenylacetic acid cyclopentyl ester 0
                    (3R)-N-hydroxy-4-[(4-methoxyphenyl)sulfonyl]-2,2-dimethyl-1,4-thiazepane-3-carboxamide 0
                    (3S)-4-\{[4-(but-2-ynyloxy)phenyl]sulfonyl\}-N-hydroxy-2,2-dimethylthiomorpholine-3-carboxamide 0
                    (4R)-1-benzyl-N-hydroxy-3-[(4-methoxyphenyl)sulfonyl]-6-oxohexahydropyrimidine-4-carboxamide 0
                    (Z)-N-hydroxy-11-methyldodec-2-enamide 0
                    2-(3,4-dihydro-3-oxo-2H-benzo[b][1,4]thiazin-2-yl)-N-hydroxyacetamide 0
                    4-(\{4-[(4-aminobut-2-ynyl)oxy]phenyl\}sulfonyl)-N-hydroxy-2,2-dimethylthiomorpholine-3-carboxamide 0
                    4-(\{[4-(but-2-yn-1-yloxy)phenyl]sulfonyl\}methyl)-1-[(3,5-dimethylisoxazol-4-yl)sulfonyl]-N-hydroxypiperidine-4-carboxamide 0
                    4-(dimethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]benzamide 0
                    BW B70C 0
                    CG-1521 0
                    CHIR-090 0
                    Confluenine A 0
                    Confluenine B 0
                    Confluenine C 0
                    Confluenine D 0
                    IC202A 0
                    IC202B 0
                    IC202C 0
                    JH-02215 0
                    L-arginine hydroxamate 0
                    Linoleyl hydroxamic acid 0
                    MC1568 0
                    MMP9 inhibitor I 0
                    N(2)-([biphenyl]-4-ylsulfonyl)-N-hydroxy-N(2)-isopropoxy-D-valinamide 0
                    N(5)-anhydromevalonyl-N(5)-hydroxy-L-ornithine 0
                    N,N'-dihydroxyoctanediamide 0
                    N-(4-\{[(1R)-1-(hydroxycarbamoyl)-2-methylpropyl](2-morpholin-4-ylethyl)sulfamoyl\}phenyl)-4-pentylbenzamide 0
                    N-hydroxy-1,3-bis[(4-methoxyphenyl)sulfonyl]-5,5-dimethylhexahydropyrimidine-2-carboxamide 0
                    N-hydroxy-2-propylpentanamide 0
                    N-hydroxy-4-acetylaminobiphenyl 0
                    N-hydroxy-L-aspartic 1-amide 0
                    acetohydroxamic acids + 0
                    batimastat 0
                    belinostat 0
                    benzyl (3R)-3-[(hydroxyamino)carbonyl]-4-[(4-methoxyphenyl)sulfonyl]piperazine-1-carboxylate 0
                    beta-L-aspartylhydroxamic acid 0
                    bisucaberin B 0
                    bufexamac 0
                    coelichelin 0
                    cyclic hydroxamic acid + 0
                    desferrialbomycins + 0
                    desferricoprogen 0
                    desferricoprogen B 0
                    desferrioxamine + 1
                    fosmidomycin 0
                    glutamine hydroxamate 0
                    glycine hydroxamate 0
                    hydroxamic acid ester + 0
                    ibuproxam 0
                    ilomastat 0
                    marimastat 0
                    methioninehydroxamic acid 0
                    n-decanohydroxamic acid 0
                    oxametacin 0
                    panobinostat 0
                    phosphoglycolohydroxamic acid 0
                    phosphonoacetohydroxamic acid 0
                    pracinostat 0
                    pre-pseudomonine 0
                    prinomastat 0
                    pyrrolidinehydroxamic acid + 0
                    rhizobactin 1021 0
                    rhodotorulic acid 0
                    salicylhydroxamic acid 0
                    schizokinen 0
                    serine hydroxamate 0
                    tepoxalin 0
                    tert-butyl 4-(\{[4-(but-2-yn-1-ylamino)phenyl]sulfonyl\}methyl)-4-[(hydroxyamino)carbonyl]piperidine-1-carboxylate 0
                    trichostatin A + 0
                    tubastatin A 0
                    vorinostat 3
Path 2
Term Annotations click to browse term
  CHEBI ontology 499
    subatomic particle 499
      composite particle 499
        hadron 499
          baryon 499
            nucleon 499
              atomic nucleus 499
                atom 499
                  main group element atom 492
                    p-block element atom 492
                      carbon group element atom 481
                        carbon atom 480
                          organic molecular entity 480
                            heteroorganic entity 476
                              organochalcogen compound 430
                                organooxygen compound 428
                                  carbon oxoacid 368
                                    carboxylic acid 368
                                      carboacyl group 307
                                        univalent carboacyl group 307
                                          carbamoyl group 305
                                            carboxamide 305
                                              hydroxamic acid 4
                                                (2R)-N-hydroxy-2-[(3S)-3-methyl-3-\{4-[(2-methylquinolin-4-yl)methoxy]phenyl\}-2-oxopyrrolidin-1-yl]propanamide 0
                                                (2S)-2-[[(2R)-2-[(1S)-1-hydroxy-2-(hydroxyamino)-2-oxoethyl]-4-methyl-1-oxopentyl]amino]-2-phenylacetic acid cyclopentyl ester 0
                                                (3R)-N-hydroxy-4-[(4-methoxyphenyl)sulfonyl]-2,2-dimethyl-1,4-thiazepane-3-carboxamide 0
                                                (3S)-4-\{[4-(but-2-ynyloxy)phenyl]sulfonyl\}-N-hydroxy-2,2-dimethylthiomorpholine-3-carboxamide 0
                                                (4R)-1-benzyl-N-hydroxy-3-[(4-methoxyphenyl)sulfonyl]-6-oxohexahydropyrimidine-4-carboxamide 0
                                                (Z)-N-hydroxy-11-methyldodec-2-enamide 0
                                                2-(3,4-dihydro-3-oxo-2H-benzo[b][1,4]thiazin-2-yl)-N-hydroxyacetamide 0
                                                4-(\{4-[(4-aminobut-2-ynyl)oxy]phenyl\}sulfonyl)-N-hydroxy-2,2-dimethylthiomorpholine-3-carboxamide 0
                                                4-(\{[4-(but-2-yn-1-yloxy)phenyl]sulfonyl\}methyl)-1-[(3,5-dimethylisoxazol-4-yl)sulfonyl]-N-hydroxypiperidine-4-carboxamide 0
                                                4-(dimethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]benzamide 0
                                                BW B70C 0
                                                CG-1521 0
                                                CHIR-090 0
                                                Confluenine A 0
                                                Confluenine B 0
                                                Confluenine C 0
                                                Confluenine D 0
                                                IC202A 0
                                                IC202B 0
                                                IC202C 0
                                                JH-02215 0
                                                L-arginine hydroxamate 0
                                                Linoleyl hydroxamic acid 0
                                                MC1568 0
                                                MMP9 inhibitor I 0
                                                N(2)-([biphenyl]-4-ylsulfonyl)-N-hydroxy-N(2)-isopropoxy-D-valinamide 0
                                                N(5)-anhydromevalonyl-N(5)-hydroxy-L-ornithine 0
                                                N,N'-dihydroxyoctanediamide 0
                                                N-(4-\{[(1R)-1-(hydroxycarbamoyl)-2-methylpropyl](2-morpholin-4-ylethyl)sulfamoyl\}phenyl)-4-pentylbenzamide 0
                                                N-hydroxy-1,3-bis[(4-methoxyphenyl)sulfonyl]-5,5-dimethylhexahydropyrimidine-2-carboxamide 0
                                                N-hydroxy-2-propylpentanamide 0
                                                N-hydroxy-4-acetylaminobiphenyl 0
                                                N-hydroxy-L-aspartic 1-amide 0
                                                acetohydroxamic acids + 0
                                                batimastat 0
                                                belinostat 0
                                                benzyl (3R)-3-[(hydroxyamino)carbonyl]-4-[(4-methoxyphenyl)sulfonyl]piperazine-1-carboxylate 0
                                                beta-L-aspartylhydroxamic acid 0
                                                bisucaberin B 0
                                                bufexamac 0
                                                coelichelin 0
                                                cyclic hydroxamic acid + 0
                                                desferrialbomycins + 0
                                                desferricoprogen 0
                                                desferricoprogen B 0
                                                desferrioxamine + 1
                                                fosmidomycin 0
                                                glutamine hydroxamate 0
                                                glycine hydroxamate 0
                                                hydroxamic acid ester + 0
                                                ibuproxam 0
                                                ilomastat 0
                                                marimastat 0
                                                methioninehydroxamic acid 0
                                                n-decanohydroxamic acid 0
                                                oxametacin 0
                                                panobinostat 0
                                                phosphoglycolohydroxamic acid 0
                                                phosphonoacetohydroxamic acid 0
                                                pracinostat 0
                                                pre-pseudomonine 0
                                                prinomastat 0
                                                pyrrolidinehydroxamic acid + 0
                                                rhizobactin 1021 0
                                                rhodotorulic acid 0
                                                salicylhydroxamic acid 0
                                                schizokinen 0
                                                serine hydroxamate 0
                                                tepoxalin 0
                                                tert-butyl 4-(\{[4-(but-2-yn-1-ylamino)phenyl]sulfonyl\}methyl)-4-[(hydroxyamino)carbonyl]piperidine-1-carboxylate 0
                                                trichostatin A + 0
                                                tubastatin A 0
                                                vorinostat 3
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