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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:imidazolidine-2,4-dione
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Accession:CHEBI:24628 term browser browse the term
Definition:An imidazolidinone with oxo groups at position 2 and 4.


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iprodione term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AHR aryl hydrocarbon receptor multiple interactions EXP [iprodione binds to and results in increased activity of AHR protein] which results in increased activity of CYP1A1 protein CTD PMID:24389113 NCBI chr14:31,743,704...31,793,484
Ensembl chr14:31,686,170...31,791,444 		JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 multiple interactions EXP [iprodione binds to and results in increased activity of AHR protein] which results in increased activity of CYP1A1 protein CTD PMID:24389113 NCBI chr30:37,793,277...37,799,535
Ensembl chr30:37,793,508...37,796,866 		JBrowse link
mephenytoin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP2B6 cytochrome P450 2B11 increases hydroxylation EXP CYP2B6 protein results in increased hydroxylation of Mephenytoin CTD PMID:12637241 NCBI chr 1:112,817,561...112,833,294
Ensembl chr 1:112,816,502...112,833,293 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 494
    chemical entity 501
      atom 494
        nonmetal atom 487
          nitrogen atom 419
            nitrogen molecular entity 411
              organonitrogen compound 404
                organonitrogen heterocyclic compound 375
                  diazolidine 3
                    imidazolidines 3
                      imidazolidinone 3
                        imidazolidine-2,4-dione 3
                          (5R)-5-methylimidazolidine-2,4-dione 0
                          (5S)-5-methylimidazolidine-2,4-dione 0
                          (5S,5aR,8aS,8bR)-7-tert-butyl-5-(4-methoxyphenyl)-8b-methyl-2-(3-methylphenyl)-5a,8a-dihydro-5H-pyrrolo[1,2]pyrrolo[4,5-a]imidazole-1,3,6,8-tetrone 0
                          (S)-Mephenytoin 0
                          1-(hydroxymethyl)-5,5-dimethylhydantoin 0
                          1-Aminohydantoin 0
                          1-[(5-nitro-2-furanyl)methylideneamino]imidazolidine-2,4-dione 0
                          2-(2',5'-dioxo-1'-spiro[3,4-dihydro-2H-1-benzopyran-4,4'-imidazolidine]yl)-N-[4-[ethyl(propan-2-yl)amino]phenyl]acetamide 0
                          2-(2,5-dioxo-4,4-dipropyl-1-imidazolidinyl)-N-(3-methoxyphenyl)acetamide 0
                          2-(2,5-dioxo-4-imidazolidinyl)-N-(1-naphthalenyl)acetamide 0
                          2-(4-butyl-4-methyl-2,5-dioxo-1-imidazolidinyl)-N-[4-(4-morpholinylsulfonyl)phenyl]acetamide 0
                          2-[4-(2-furanylmethylidene)-2,5-dioxo-1-imidazolidinyl]-N-(4-methylphenyl)acetamide 0
                          2-[4-(4-methoxyphenyl)-4-methyl-2,5-dioxo-1-imidazolidinyl]-N-[4-(6-methyl-1,3-benzothiazol-2-yl)phenyl]acetamide 0
                          2-[4-[(1-ethyl-2,5-dimethyl-3-pyrrolyl)methylidene]-2,5-dioxo-1-imidazolidinyl]-N-(3-methylphenyl)acetamide 0
                          2-[4-[(3-ethoxy-4-hydroxyphenyl)methylidene]-2,5-dioxo-1-imidazolidinyl]-N-(3-methylphenyl)acetamide 0
                          2-[4-[4-(difluoromethoxy)phenyl]-4-methyl-2,5-dioxo-1-imidazolidinyl]acetic acid ethyl ester 0
                          2-[[2-(4-ethyl-4-methyl-2,5-dioxo-1-imidazolidinyl)-1-oxoethyl]amino]-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxamide 0
                          3',4'-Dihydrodiol 0
                          3'-HPPH 0
                          3,6,8-Trimethylallantoin 0
                          3-(\{(5R)-3-[3-(1H-imidazol-1-yl)propyl]-5-methyl-5-naphthalen-1-yl-2,4-dioxoimidazolidin-1-yl\}methyl)benzonitrile 0
                          3-Methylhydantoin 0
                          3-[(2-fluorophenyl)methyl]-5-(1H-indol-3-ylmethylidene)imidazolidine-2,4-dione 0
                          3-[(2-fluorophenyl)methyl]-5-[(5-methyl-2-furanyl)methylidene]imidazolidine-2,4-dione 0
                          3-[(4S)-2,5-dioxoimidazolidin-4-yl]propanoic acid 0
                          3-[2-[4-(4-chlorophenyl)sulfonyl-1-piperazinyl]-2-oxoethyl]-5-(2-methylpropyl)imidazolidine-2,4-dione 0
                          3-[2-[[1-(3-chlorophenyl)-2,5-dioxo-4-imidazolidinylidene]methyl]-1-pyrrolyl]benzoic acid 0
                          3-[2-hydroxy-3-(4-morpholinyl)propyl]-5,5-dimethylimidazolidine-2,4-dione 0
                          4-Hydroxy-1-[(Z)-[(5-nitrofuran-2-yl)methylidene]amino]-2,5-dihydro-1H-imidazol-2-one 0
                          4-[(2,4-dioxo-1,3-diazaspiro[4.5]decan-3-yl)methyl]benzoic acid methyl ester 0
                          4-[2-[(2,5-dioxo-1-phenyl-4-imidazolidinylidene)methyl]-1-pyrrolyl]benzoic acid 0
                          4-[5-[[1-[(2-chlorophenyl)methyl]-2,5-dioxo-4-imidazolidinylidene]methyl]-2-furanyl]-3-methylbenzoic acid 0
                          4-[[2-ethoxy-4-[(1-ethyl-2,5-dioxo-4-imidazolidinylidene)methyl]-6-prop-2-enylphenoxy]methyl]benzoic acid 0
                          4-hydroxyphenytoin 0
                          5,5-Bis(4-hydroxyphenyl)hydantoin 0
                          5,5-Dimethylhydantoin 0
                          5-(2-furanylmethylidene)imidazolidine-2,4-dione 0
                          5-(3,4-Dihydroxy-1,5-cyclohexadien-1-yl)-5-phenylhydantoin 0
                          5-(4-hydroxybutyl)hydantoin 0
                          5-Hydroxydantrolene 0
                          5-[(1-ethyl-2,5-dimethyl-3-pyrrolyl)methylidene]-3-phenylimidazolidine-2,4-dione 0
                          5-[(2,4,5-trihydroxyphenyl)methyl]imidazolidine-2,4-dione 0
                          5-[[2,5-dimethyl-1-(3-pyridinyl)-3-pyrrolyl]methylidene]-3-phenylimidazolidine-2,4-dione 0
                          5-guanidinohydantoin 0
                          5-hydroxyhydantoin 0
                          5-methyl-3-[2-(4-morpholinyl)-2-oxoethyl]-5-phenylimidazolidine-2,4-dione 0
                          5-methylimidazolidine-2,4-dione 0
                          7-[3-(3-cyclohexyl-3-hydroxypropyl)-2,5-dioxoimidazolidin-4-yl]heptanoic acid + 0
                          Alloxanoic acid 4tms NIST 0
                          Aminofurantoin 0
                          Azimilide 0
                          BW A868C 0
                          D-5-monosubstituted hydantoin + 0
                          Fosphenytoin 0
                          Hydantocidin 0
                          Hydroxymephenytoin 0
                          Idanpramine 0
                          L-5-benzyl-hydantoin 0
                          L-5-carboxymethylhydantoin 0
                          L-5-monosubstituted hydantoin + 0
                          N-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-[4-methyl-2,5-dioxo-4-(2-phenylethyl)-1-imidazolidinyl]acetamide 0
                          N-(3-cyanophenyl)-2-(4-ethyl-2,5-dioxo-4-phenyl-1-imidazolidinyl)acetamide 0
                          N-(3-methylphenyl)-2-[4-[(5-methyl-2-thiophenyl)methylidene]-2,5-dioxo-1-imidazolidinyl]acetamide 0
                          N-(4-ethoxyphenyl)-2-[4-[2-(methylthio)ethyl]-2,5-dioxo-1-imidazolidinyl]acetamide 0
                          N-(4-methylphenyl)-2-[4-[(5-methyl-2-thiophenyl)methylidene]-2,5-dioxo-1-imidazolidinyl]acetamide 0
                          N-[3-(1-azepanylsulfonyl)phenyl]-2-[4-(1H-indol-3-ylmethyl)-2,5-dioxo-1-imidazolidinyl]acetamide 0
                          N-[4-(6-methyl-1,3-benzothiazol-2-yl)phenyl]-2-[4-methyl-4-(4-methylphenyl)-2,5-dioxo-1-imidazolidinyl]acetamide 0
                          N-methylhydantoin 0
                          Nirvanol 0
                          Phenytoin arene-oxide 0
                          Phenytoin methylcatechol 0
                          RO4927350 0
                          S-nirvanol 0
                          allantoin + 0
                          amino(diphenylhydantoin) valeric acid 0
                          azumolene 0
                          clodantoin 0
                          dantrolene 0
                          diazolidinylurea 0
                          ethotoin + 0
                          furagin 0
                          hydantoin + 0
                          hydantoin-5-propionic acid 0
                          iprodione 2
                          mephenytoin 1
                          nifurfoline 0
                          nifurtoinol 0
                          nitrofurantoin 0
                          p-Hydroxyl-ethotoin 0
                          phenytoin 0
                          phethenylate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 494
    subatomic particle 494
      composite particle 494
        hadron 501
          baryon 494
            nucleon 494
              atomic nucleus 494
                atom 494
                  main group element atom 487
                    p-block element atom 487
                      carbon group element atom 476
                        carbon atom 482
                          organic molecular entity 475
                            organic molecule 466
                              organic cyclic compound 449
                                organic heterocyclic compound 419
                                  organic heteromonocyclic compound 334
                                    diazolidine 3
                                      imidazolidines 3
                                        imidazolidinone 3
                                          imidazolidine-2,4-dione 3
                                            (5R)-5-methylimidazolidine-2,4-dione 0
                                            (5S)-5-methylimidazolidine-2,4-dione 0
                                            (5S,5aR,8aS,8bR)-7-tert-butyl-5-(4-methoxyphenyl)-8b-methyl-2-(3-methylphenyl)-5a,8a-dihydro-5H-pyrrolo[1,2]pyrrolo[4,5-a]imidazole-1,3,6,8-tetrone 0
                                            (S)-Mephenytoin 0
                                            1-(hydroxymethyl)-5,5-dimethylhydantoin 0
                                            1-Aminohydantoin 0
                                            1-[(5-nitro-2-furanyl)methylideneamino]imidazolidine-2,4-dione 0
                                            2-(2',5'-dioxo-1'-spiro[3,4-dihydro-2H-1-benzopyran-4,4'-imidazolidine]yl)-N-[4-[ethyl(propan-2-yl)amino]phenyl]acetamide 0
                                            2-(2,5-dioxo-4,4-dipropyl-1-imidazolidinyl)-N-(3-methoxyphenyl)acetamide 0
                                            2-(2,5-dioxo-4-imidazolidinyl)-N-(1-naphthalenyl)acetamide 0
                                            2-(4-butyl-4-methyl-2,5-dioxo-1-imidazolidinyl)-N-[4-(4-morpholinylsulfonyl)phenyl]acetamide 0
                                            2-[4-(2-furanylmethylidene)-2,5-dioxo-1-imidazolidinyl]-N-(4-methylphenyl)acetamide 0
                                            2-[4-(4-methoxyphenyl)-4-methyl-2,5-dioxo-1-imidazolidinyl]-N-[4-(6-methyl-1,3-benzothiazol-2-yl)phenyl]acetamide 0
                                            2-[4-[(1-ethyl-2,5-dimethyl-3-pyrrolyl)methylidene]-2,5-dioxo-1-imidazolidinyl]-N-(3-methylphenyl)acetamide 0
                                            2-[4-[(3-ethoxy-4-hydroxyphenyl)methylidene]-2,5-dioxo-1-imidazolidinyl]-N-(3-methylphenyl)acetamide 0
                                            2-[4-[4-(difluoromethoxy)phenyl]-4-methyl-2,5-dioxo-1-imidazolidinyl]acetic acid ethyl ester 0
                                            2-[[2-(4-ethyl-4-methyl-2,5-dioxo-1-imidazolidinyl)-1-oxoethyl]amino]-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxamide 0
                                            3',4'-Dihydrodiol 0
                                            3'-HPPH 0
                                            3,6,8-Trimethylallantoin 0
                                            3-(\{(5R)-3-[3-(1H-imidazol-1-yl)propyl]-5-methyl-5-naphthalen-1-yl-2,4-dioxoimidazolidin-1-yl\}methyl)benzonitrile 0
                                            3-Methylhydantoin 0
                                            3-[(2-fluorophenyl)methyl]-5-(1H-indol-3-ylmethylidene)imidazolidine-2,4-dione 0
                                            3-[(2-fluorophenyl)methyl]-5-[(5-methyl-2-furanyl)methylidene]imidazolidine-2,4-dione 0
                                            3-[(4S)-2,5-dioxoimidazolidin-4-yl]propanoic acid 0
                                            3-[2-[4-(4-chlorophenyl)sulfonyl-1-piperazinyl]-2-oxoethyl]-5-(2-methylpropyl)imidazolidine-2,4-dione 0
                                            3-[2-[[1-(3-chlorophenyl)-2,5-dioxo-4-imidazolidinylidene]methyl]-1-pyrrolyl]benzoic acid 0
                                            3-[2-hydroxy-3-(4-morpholinyl)propyl]-5,5-dimethylimidazolidine-2,4-dione 0
                                            4-Hydroxy-1-[(Z)-[(5-nitrofuran-2-yl)methylidene]amino]-2,5-dihydro-1H-imidazol-2-one 0
                                            4-[(2,4-dioxo-1,3-diazaspiro[4.5]decan-3-yl)methyl]benzoic acid methyl ester 0
                                            4-[2-[(2,5-dioxo-1-phenyl-4-imidazolidinylidene)methyl]-1-pyrrolyl]benzoic acid 0
                                            4-[5-[[1-[(2-chlorophenyl)methyl]-2,5-dioxo-4-imidazolidinylidene]methyl]-2-furanyl]-3-methylbenzoic acid 0
                                            4-[[2-ethoxy-4-[(1-ethyl-2,5-dioxo-4-imidazolidinylidene)methyl]-6-prop-2-enylphenoxy]methyl]benzoic acid 0
                                            4-hydroxyphenytoin 0
                                            5,5-Bis(4-hydroxyphenyl)hydantoin 0
                                            5,5-Dimethylhydantoin 0
                                            5-(2-furanylmethylidene)imidazolidine-2,4-dione 0
                                            5-(3,4-Dihydroxy-1,5-cyclohexadien-1-yl)-5-phenylhydantoin 0
                                            5-(4-hydroxybutyl)hydantoin 0
                                            5-Hydroxydantrolene 0
                                            5-[(1-ethyl-2,5-dimethyl-3-pyrrolyl)methylidene]-3-phenylimidazolidine-2,4-dione 0
                                            5-[(2,4,5-trihydroxyphenyl)methyl]imidazolidine-2,4-dione 0
                                            5-[[2,5-dimethyl-1-(3-pyridinyl)-3-pyrrolyl]methylidene]-3-phenylimidazolidine-2,4-dione 0
                                            5-guanidinohydantoin 0
                                            5-hydroxyhydantoin 0
                                            5-methyl-3-[2-(4-morpholinyl)-2-oxoethyl]-5-phenylimidazolidine-2,4-dione 0
                                            5-methylimidazolidine-2,4-dione 0
                                            7-[3-(3-cyclohexyl-3-hydroxypropyl)-2,5-dioxoimidazolidin-4-yl]heptanoic acid + 0
                                            Alloxanoic acid 4tms NIST 0
                                            Aminofurantoin 0
                                            Azimilide 0
                                            BW A868C 0
                                            D-5-monosubstituted hydantoin + 0
                                            Fosphenytoin 0
                                            Hydantocidin 0
                                            Hydroxymephenytoin 0
                                            Idanpramine 0
                                            L-5-benzyl-hydantoin 0
                                            L-5-carboxymethylhydantoin 0
                                            L-5-monosubstituted hydantoin + 0
                                            N-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-[4-methyl-2,5-dioxo-4-(2-phenylethyl)-1-imidazolidinyl]acetamide 0
                                            N-(3-cyanophenyl)-2-(4-ethyl-2,5-dioxo-4-phenyl-1-imidazolidinyl)acetamide 0
                                            N-(3-methylphenyl)-2-[4-[(5-methyl-2-thiophenyl)methylidene]-2,5-dioxo-1-imidazolidinyl]acetamide 0
                                            N-(4-ethoxyphenyl)-2-[4-[2-(methylthio)ethyl]-2,5-dioxo-1-imidazolidinyl]acetamide 0
                                            N-(4-methylphenyl)-2-[4-[(5-methyl-2-thiophenyl)methylidene]-2,5-dioxo-1-imidazolidinyl]acetamide 0
                                            N-[3-(1-azepanylsulfonyl)phenyl]-2-[4-(1H-indol-3-ylmethyl)-2,5-dioxo-1-imidazolidinyl]acetamide 0
                                            N-[4-(6-methyl-1,3-benzothiazol-2-yl)phenyl]-2-[4-methyl-4-(4-methylphenyl)-2,5-dioxo-1-imidazolidinyl]acetamide 0
                                            N-methylhydantoin 0
                                            Nirvanol 0
                                            Phenytoin arene-oxide 0
                                            Phenytoin methylcatechol 0
                                            RO4927350 0
                                            S-nirvanol 0
                                            allantoin + 0
                                            amino(diphenylhydantoin) valeric acid 0
                                            azumolene 0
                                            clodantoin 0
                                            dantrolene 0
                                            diazolidinylurea 0
                                            ethotoin + 0
                                            furagin 0
                                            hydantoin + 0
                                            hydantoin-5-propionic acid 0
                                            iprodione 2
                                            mephenytoin 1
                                            nifurfoline 0
                                            nifurtoinol 0
                                            nitrofurantoin 0
                                            p-Hydroxyl-ethotoin 0
                                            phenytoin 0
                                            phethenylate 0
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