Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:imidazolidine-2,4-dione
go back to main search page
Accession:CHEBI:24628 term browser browse the term
Definition:An imidazolidinone with oxo groups at position 2 and 4.


show annotations for term's descendants           Sort by:
 
4-hydroxyphenytoin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 multiple interactions ISO UGT1A1 protein results in increased glucuronidation of and results in decreased activity of hydroxyphenytoin CTD PMID:15855726 NCBI chr 9:95,295,701...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a5 UDP glucuronosyltransferase family 1 member A5 multiple interactions ISO UGT1A4 protein results in increased glucuronidation of and results in decreased activity of hydroxyphenytoin CTD PMID:15855726 NCBI chr 9:95,256,628...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 multiple interactions ISO UGT1A6 protein results in increased glucuronidation of and results in decreased activity of hydroxyphenytoin CTD PMID:15855726 NCBI chr 9:95,241,609...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 multiple interactions ISO UGT1A9 protein results in increased glucuronidation of and results in decreased activity of hydroxyphenytoin CTD PMID:15855726 NCBI chr 9:95,161,157...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
7-[3-(3-cyclohexyl-3-hydroxypropyl)-2,5-dioxoimidazolidin-4-yl]heptanoic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ptgdr prostaglandin D2 receptor multiple interactions ISO
EXP
BW 245C binds to and results in increased activity of PTGDR protein; BW 245C inhibits the reaction [Prostaglandin D2 binds to PTGDR protein] CTD PMID:9579725 PMID:15528449 PMID:20719937 NCBI chr15:19,195,606...19,196,508 JBrowse link
G Tgfb1 transforming growth factor, beta 1 decreases response to substance ISO BW 245C results in decreased susceptibility to TGFB1 protein CTD PMID:20719937 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
allantoin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Col2a1 collagen type II alpha 1 chain multiple interactions EXP [COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Allantoin; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Allantoin]; huang-lien-chieh-tu-tang inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Allantoin] CTD PMID:24709313 NCBI chr 7:139,454,945...139,484,403
Ensembl chr 7:139,455,242...139,483,997
JBrowse link
G Lepr leptin receptor affects abundance ISO LEPR affects the abundance of Allantoin CTD PMID:20567778 NCBI chr 5:120,503,475...120,682,281
Ensembl chr 5:120,564,645...120,682,221
JBrowse link
G Xdh xanthine dehydrogenase multiple interactions EXP [2,2,5,7,8-pentamethyl-1-hydroxychroman results in decreased activity of XDH protein] which results in decreased abundance of Allantoin CTD PMID:21920950 NCBI chr 6:25,149,570...25,211,273
Ensembl chr 6:25,149,235...25,211,494
JBrowse link
Azimilide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity
multiple interactions
ISO azimilide results in decreased activity of KCNH2 protein
Acids inhibits the reaction [azimilide results in decreased activity of KCNH2 protein]; azimilide promotes the reaction [naringenin results in decreased activity of KCNH2 protein]; naringenin promotes the reaction [azimilide results in decreased activity of KCNH2 protein]; Potassium inhibits the reaction [azimilide results in decreased activity of KCNH2 protein]
CTD PMID:15821840 PMID:16960444 PMID:18057881 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253
JBrowse link
dantrolene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcg2 ATP binding cassette subfamily G member 2 affects transport ISO ABCG2 protein affects the transport of Dantrolene CTD PMID:18322075 NCBI chr 4:88,765,441...88,890,268
Ensembl chr 4:88,832,178...88,890,621
JBrowse link
G Atf4 activating transcription factor 4 decreases expression
multiple interactions
EXP
ISO
Dantrolene results in decreased expression of ATF4 protein
Dantrolene affects the reaction [perfluorooctanoic acid results in increased expression of ATF4 protein]; Dantrolene inhibits the reaction [Thapsigargin results in increased expression of ATF4 protein]; Dantrolene promotes the reaction [Thapsigargin results in increased expression of ATF4 mRNA]
CTD PMID:15921666 PMID:32578922 NCBI chr 7:121,480,723...121,482,781
Ensembl chr 7:121,480,723...121,482,772
JBrowse link
G Bcl2 BCL2, apoptosis regulator increases expression EXP Dantrolene results in increased expression of BCL2 protein CTD PMID:10854250 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bdnf brain-derived neurotrophic factor multiple interactions ISO Dantrolene inhibits the reaction [Oxygen deficiency results in increased secretion of BDNF protein] CTD PMID:16553631 NCBI chr 3:100,768,637...100,819,216
Ensembl chr 3:100,768,637...100,819,210
JBrowse link
G Capn1 calpain 1 decreases expression EXP Dantrolene results in decreased expression of CAPN1 mRNA; Dantrolene results in decreased expression of CAPN1 protein CTD PMID:11236903 NCBI chr 1:221,346,081...221,370,965
Ensembl chr 1:221,346,066...221,370,322
JBrowse link
G Capn2 calpain 2 decreases expression EXP Dantrolene results in decreased expression of CAPN2 mRNA; Dantrolene results in decreased expression of CAPN2 protein CTD PMID:11236903 NCBI chr13:100,878,649...100,928,811
Ensembl chr13:100,878,650...100,928,811
JBrowse link
G Capn3 calpain 3 decreases expression EXP Dantrolene results in decreased expression of CAPN3 mRNA; Dantrolene results in decreased expression of CAPN3 protein CTD PMID:11236903 NCBI chr 3:112,227,486...112,278,408
Ensembl chr 3:112,228,720...112,278,408
JBrowse link
G Casp3 caspase 3 multiple interactions EXP
ISO
Dantrolene inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein]
Dantrolene inhibits the reaction [Indomethacin results in increased activity of CASP3 protein]
CTD PMID:17079870 PMID:23022152 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp9 caspase 9 multiple interactions ISO Dantrolene inhibits the reaction [Indomethacin results in increased activity of CASP9 protein] CTD PMID:23022152 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases expression EXP Dantrolene results in decreased expression of CCL2 mRNA CTD PMID:25051504 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 affects expression EXP Dantrolene affects the expression of CCL5 protein CTD PMID:25051504 NCBI chr10:70,739,764...70,744,303
Ensembl chr10:70,739,800...70,744,315
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO
EXP
Dantrolene inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein] CTD PMID:18493746 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions ISO Dantrolene inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A2 protein] CTD PMID:18493746 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 decreases phosphorylation
multiple interactions
EXP
ISO
Dantrolene results in decreased phosphorylation of DDIT3 protein
Dantrolene promotes the reaction [perfluorooctanoic acid results in increased expression of DDIT3 mRNA]; Dantrolene promotes the reaction [perfluorooctanoic acid results in increased expression of DDIT3 protein]
CTD PMID:15921666 PMID:32578922 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
JBrowse link
G Edn1 endothelin 1 decreases activity EXP Dantrolene results in decreased activity of EDN1 protein CTD PMID:12628492 NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324
JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 decreases phosphorylation EXP Dantrolene results in decreased phosphorylation of EIF2AK3 protein CTD PMID:15921666 NCBI chr 4:98,648,513...98,709,695
Ensembl chr 4:98,648,545...98,709,694
JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha decreases phosphorylation
multiple interactions
EXP
ISO
Dantrolene results in decreased phosphorylation of EIF2S1 protein
Dantrolene inhibits the reaction [tributyltin results in increased phosphorylation of EIF2S1 protein]
CTD PMID:15921666 PMID:23743301 NCBI chr 6:102,048,372...102,073,041
Ensembl chr 6:102,048,372...102,073,041
JBrowse link
G Gfap glial fibrillary acidic protein multiple interactions EXP Dantrolene inhibits the reaction [diphenylditelluride results in decreased phosphorylation of GFAP protein]; Dantrolene inhibits the reaction [diphenylditelluride results in increased phosphorylation of GFAP protein] CTD PMID:21863293 PMID:21879721 NCBI chr10:90,990,762...90,999,435
Ensembl chr10:90,990,762...90,999,506
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions ISO Dantrolene inhibits the reaction [tributyltin results in increased expression of HSPA5 protein] CTD PMID:23743301 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
JBrowse link
G Ifng interferon gamma multiple interactions ISO Dantrolene inhibits the reaction [taurolithocholic acid 3-sulfate results in increased expression of IFNG mRNA] CTD PMID:22517774 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Igf1 insulin-like growth factor 1 decreases response to substance ISO Dantrolene results in decreased susceptibility to IGF1 protein CTD PMID:16485066 NCBI chr 7:28,412,123...28,491,815
Ensembl chr 7:28,412,198...28,486,609
JBrowse link
G Igf2 insulin-like growth factor 2 decreases response to substance ISO Dantrolene results in decreased susceptibility to IGF2 protein CTD PMID:16485066 NCBI chr 1:215,828,102...215,839,081
Ensembl chr 1:215,828,102...215,846,911
JBrowse link
G Il10 interleukin 10 multiple interactions
affects expression
ISO
EXP
Dantrolene inhibits the reaction [[chlorocresol results in increased activity of RYR1 protein] inhibits the reaction [Lipopolysaccharides results in increased expression of IL10 protein]]
Dantrolene affects the expression of IL10 protein
CTD PMID:17707769 PMID:25051504 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il1b interleukin 1 beta affects expression EXP Dantrolene affects the expression of IL1B mRNA CTD PMID:25051504 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 multiple interactions ISO Dantrolene inhibits the reaction [taurolithocholic acid 3-sulfate results in increased expression of IL6 mRNA] CTD PMID:22517774 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO Dantrolene results in decreased activity of KCNH2 protein CTD PMID:24052561 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253
JBrowse link
G Kcnj11 potassium inwardly-rectifying channel, subfamily J, member 11 multiple interactions ISO Dantrolene inhibits the reaction [KCNJ11 protein mutant form results in increased abundance of Calcium] CTD PMID:17189350 NCBI chr 1:102,103,093...102,107,134
Ensembl chr 1:102,103,094...102,106,127
JBrowse link
G Lep leptin decreases expression EXP Dantrolene results in decreased expression of LEP protein CTD PMID:25051504 NCBI chr 4:56,337,695...56,351,818
Ensembl chr 4:56,337,695...56,351,818
JBrowse link
G Mef2a myocyte enhancer factor 2a multiple interactions EXP Dantrolene inhibits the reaction [Caffeine results in increased expression of MEF2A mRNA]; Dantrolene inhibits the reaction [Caffeine results in increased expression of MEF2A protein] CTD PMID:25093688 NCBI chr 1:128,207,715...128,341,681
Ensembl chr 1:128,209,971...128,341,263
JBrowse link
G Mef2c myocyte enhancer factor 2C multiple interactions EXP Dantrolene inhibits the reaction [Caffeine results in increased expression of MEF2C mRNA]; Dantrolene inhibits the reaction [Caffeine results in increased expression of MEF2C protein] CTD PMID:25093688 NCBI chr 2:11,658,534...11,822,788
Ensembl chr 2:11,658,568...11,822,787
JBrowse link
G Myh7 myosin heavy chain 7 multiple interactions EXP Dantrolene inhibits the reaction [Caffeine results in increased expression of MYH7 mRNA] CTD PMID:25093688 NCBI chr15:33,605,769...33,657,761
Ensembl chr15:33,634,422...33,656,089
JBrowse link
G Nefl neurofilament light multiple interactions EXP Dantrolene inhibits the reaction [diphenylditelluride results in decreased phosphorylation of NEFL protein]; Dantrolene inhibits the reaction [diphenylditelluride results in increased phosphorylation of NEFL protein] CTD PMID:21863293 PMID:21879721 NCBI chr15:44,799,378...44,803,251
Ensembl chr15:44,799,334...44,804,574
JBrowse link
G Nefm neurofilament medium multiple interactions EXP Dantrolene inhibits the reaction [diphenylditelluride results in decreased phosphorylation of NEFM protein]; Dantrolene inhibits the reaction [diphenylditelluride results in increased phosphorylation of NEFM protein] CTD PMID:21863293 PMID:21879721 NCBI chr15:44,855,307...44,860,604
Ensembl chr15:44,855,310...44,860,604
JBrowse link
G Nppa natriuretic peptide A multiple interactions EXP Dantrolene inhibits the reaction [Caffeine results in increased expression of NPPA mRNA] CTD PMID:25093688 NCBI chr 5:164,808,407...164,809,716
Ensembl chr 5:164,808,323...164,809,705
JBrowse link
G Nppb natriuretic peptide B multiple interactions EXP Dantrolene inhibits the reaction [Caffeine results in increased expression of NPPB mRNA] CTD PMID:25093688 NCBI chr 5:164,796,176...164,797,538
Ensembl chr 5:164,796,185...164,797,531
JBrowse link
G Ryr1 ryanodine receptor 1 multiple interactions ISO Dantrolene inhibits the reaction [[chlorocresol results in increased activity of RYR1 protein] inhibits the reaction [Lipopolysaccharides results in increased expression of IL10 protein]]; Dantrolene inhibits the reaction [[chlorocresol results in increased activity of RYR1 protein] which results in increased transport of Calcium] CTD PMID:17707769 NCBI chr 1:87,959,596...88,066,252
Ensembl chr 1:87,959,712...88,066,101
JBrowse link
G Ryr2 ryanodine receptor 2 multiple interactions EXP Dantrolene inhibits the reaction [Caffeine promotes the reaction [RYR2 protein results in increased secretion of Calcium]] CTD PMID:12887973 NCBI chr17:65,533,998...65,955,606
Ensembl chr17:65,535,403...65,955,606
JBrowse link
G Star steroidogenic acute regulatory protein multiple interactions ISO Dantrolene inhibits the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of STAR mRNA] CTD PMID:23183170 NCBI chr16:71,036,204...71,040,847
Ensembl chr16:71,036,204...71,040,847
JBrowse link
G Tnf tumor necrosis factor decreases expression EXP Dantrolene results in decreased expression of TNF protein CTD PMID:11236903 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Vim vimentin multiple interactions EXP Dantrolene inhibits the reaction [diphenylditelluride results in decreased phosphorylation of VIM protein]; Dantrolene inhibits the reaction [diphenylditelluride results in increased phosphorylation of VIM protein] CTD PMID:21863293 PMID:21879721 NCBI chr17:80,882,715...80,891,200
Ensembl chr17:80,882,666...80,891,212
JBrowse link
G Xbp1 X-box binding protein 1 multiple interactions ISO Dantrolene inhibits the reaction [perfluorooctanoic acid results in increased expression of XBP1 mRNA alternative form]; Dantrolene inhibits the reaction [Thapsigargin results in increased expression of XBP1 mRNA alternative form] CTD PMID:32578922 NCBI chr14:85,753,736...85,758,820
Ensembl chr14:85,753,760...85,758,145
JBrowse link
ethotoin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO ethotoin binds to and results in increased activity of NR1I2 protein CTD PMID:15039302 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
iprodione term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor multiple interactions ISO
EXP
iprodione binds to and results in increased activity of AHR protein CTD PMID:14636698 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Anxa10 annexin A10 increases expression ISO iprodione results in increased expression of ANXA10 mRNA CTD PMID:32194361 NCBI chr16:29,674,699...29,741,521
Ensembl chr16:29,674,793...29,741,465
JBrowse link
G Ar androgen receptor multiple interactions
affects binding
ISO [iprodione binds to and results in decreased activity of AR protein] inhibits the reaction [Metribolone binds to AR protein]; iprodione inhibits the reaction [Dihydrotestosterone results in increased activity of AR protein]
iprodione binds to AR protein
CTD PMID:19564212 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Cldn11 claudin 11 increases expression
multiple interactions
EXP iprodione results in increased expression of CLDN11 protein
[carbendazim co-treated with iprodione] results in decreased expression of CLDN11 protein
CTD PMID:28576679 NCBI chr 2:115,823,541...115,836,846
Ensembl chr 2:115,823,538...115,836,846
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 increases activity ISO iprodione results in increased activity of CYP19A1 protein CTD PMID:11884232 NCBI chr 8:58,744,849...58,772,408
Ensembl chr 8:58,744,849...58,772,408
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression ISO iprodione results in increased expression of CYP1A1 mRNA; iprodione results in increased expression of CYP1A1 protein CTD PMID:16696176 PMID:32194361 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 decreases expression ISO iprodione results in decreased expression of CYP2C19 protein CTD PMID:32194361 NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007
JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 decreases expression ISO iprodione results in decreased expression of CYP7A1 protein CTD PMID:32194361 NCBI chr 5:19,358,734...19,368,431
Ensembl chr 5:19,358,734...19,368,431
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO iprodione results in increased expression of DDIT3 mRNA CTD PMID:16696176 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression ISO iprodione results in increased expression of FOS mRNA CTD PMID:16696176 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha increases expression ISO iprodione results in increased expression of GADD45A mRNA CTD PMID:16696176 NCBI chr 4:97,782,512...97,784,814
Ensembl chr 4:97,782,512...97,784,842
JBrowse link
G Gja1 gap junction protein, alpha 1 multiple interactions EXP [carbendazim co-treated with iprodione] results in decreased expression of GJA1 protein CTD PMID:28576679 NCBI chr20:37,876,650...37,889,097
Ensembl chr20:37,876,650...37,889,089
JBrowse link
G Gsta2 glutathione S-transferase alpha 2 increases expression ISO iprodione results in increased expression of GSTA2 mRNA CTD PMID:16696176 NCBI chr 8:85,640,081...85,645,621 JBrowse link
G H2ax H2A.X variant histone multiple interactions ISO [fludioxonil co-treated with cyprodinil co-treated with procymidone co-treated with iprodione co-treated with cyhalothrin] results in increased phosphorylation of H2AX protein CTD PMID:22389207 NCBI chr 8:48,665,652...48,666,981
Ensembl chr 8:48,665,652...48,666,981
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression ISO iprodione results in increased expression of HSPA5 mRNA CTD PMID:16696176 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO [procymidone co-treated with iprodione co-treated with cyprodinil co-treated with fludioxonil co-treated with cyhalothrin] results in increased activity of NR1I2 protein CTD PMID:25028461 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma increases activity ISO iprodione results in increased activity of PPARG protein CTD PMID:20143881 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Stmn1 stathmin 1 increases expression EXP iprodione results in increased expression of STMN1 mRNA CTD PMID:28576679 NCBI chr 5:152,680,412...152,686,807
Ensembl chr 5:152,680,407...152,686,806
JBrowse link
mephenytoin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases activity ISO Mephenytoin results in decreased activity of CYP1B1 protein CTD PMID:18420780 NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 decreases activity ISO Mephenytoin results in decreased activity of CYP2B10 protein CTD PMID:18420780 NCBI chr 7:99,142,431...99,183,540
Ensembl chr 7:99,142,450...99,181,783
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 decreases methylation
decreases activity
multiple interactions
increases metabolic processing
ISO CYP2B6 protein results in decreased methylation of Mephenytoin
Mephenytoin results in decreased activity of CYP2B6 protein
Mephenytoin inhibits the reaction [[isoimperatorin co-treated with NADP] results in decreased activity of CYP2B6 protein]; Mephenytoin inhibits the reaction [CYP2B6 protein results in decreased ethylation of 7-ethoxy-4-trifluoromethylcoumarin]; Mephenytoin inhibits the reaction [CYP2B6 protein results in increased chemical synthesis of 7-hydroxy-4-trifluoromethylcoumarin]
CYP2B6 protein results in increased metabolism of Mephenytoin
CTD PMID:9241656 PMID:12433797 PMID:12464242 PMID:25500267 NCBI chr 1:83,163,103...83,236,615
Ensembl chr 1:83,163,079...83,236,615
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 multiple interactions
increases metabolic processing
increases oxidation
affects hydroxylation
affects metabolic processing
increases hydroxylation
decreases activity
ISO 4-amino-2-phenoxymethanesulfonanilide inhibits the reaction [CYP2C19 protein results in increased oxidation of Mephenytoin]; [CYP2C19 protein results in increased metabolism of Mephenytoin] which results in increased chemical synthesis of 4-hydroxymephenytoin; [Mephenytoin results in decreased activity of CYP2C19 protein] which results in decreased degradation of vanoxerine; Fluoxetine inhibits the reaction [CYP2C19 protein results in increased hydroxylation of Mephenytoin]; Fluoxetine inhibits the reaction [CYP2C19 protein results in increased metabolism of Mephenytoin]; GH1 protein inhibits the reaction [CYP2C19 protein results in increased metabolism of Mephenytoin]; Lansoprazole inhibits the reaction [CYP2C19 protein results in increased hydroxylation of Mephenytoin]; Mephenytoin inhibits the reaction [CYP2C19 protein results in increased metabolism of 4,5-dihydropyrazole-1,5-dicarboxylic acid 1-((4-chlorophenyl)-amide) 5-(2-oxo-2H-(1,3')bipyridinyl-6'-yl)-amide]; Omeprazole inhibits the reaction [CYP2C19 protein results in increased hydroxylation of Mephenytoin]; Omeprazole inhibits the reaction [CYP2C19 protein results in increased metabolism of Mephenytoin]; Pantoprazole inhibits the reaction [CYP2C19 protein results in increased hydroxylation of Mephenytoin]; perfluorooctane sulfonic acid inhibits the reaction [CYP2C19 protein results in increased oxidation of Mephenytoin]; rabeprazole-thioether inhibits the reaction [CYP2C19 protein results in increased hydroxylation of Mephenytoin]; Resveratrol inhibits the reaction [CYP2C19 protein results in increased metabolism of Mephenytoin]; sitaxsentan inhibits the reaction [CYP2C19 protein results in increased metabolism of Mephenytoin]; Ticlopidine inhibits the reaction [CYP2C19 protein results in increased hydroxylation of Mephenytoin]; Ticlopidine inhibits the reaction [CYP2C19 protein results in increased metabolism of Mephenytoin]; Tranylcypromine inhibits the reaction [CYP2C19 protein results in increased metabolism of Mephenytoin]; ursolic acid inhibits the reaction [CYP2C19 protein results in increased metabolism of Mephenytoin]; zafirlukast inhibits the reaction [CYP2C19 protein results in increased metabolism of Mephenytoin]
CYP2C19 gene SNP affects the hydroxylation of Mephenytoin; CYP2C19 protein affects the hydroxylation of Mephenytoin
CYP2C19 protein affects the metabolism of Mephenytoin
CTD PMID:3577206 PMID:9170147 PMID:11502731 PMID:11907490 PMID:12401345 PMID:12433797 PMID:12464242 PMID:12467917 PMID:12569440 PMID:12637241 PMID:15043991 PMID:15155557 PMID:15258107 PMID:15370959 PMID:15618748 PMID:15860655 PMID:16049126 PMID:16124035 PMID:17267297 PMID:17418993 PMID:17478480 PMID:18979093 PMID:19053182 PMID:19697924 PMID:21915887 PMID:21964418 PMID:22652334 PMID:23721565 PMID:23850985 PMID:25084468 PMID:28119166 PMID:28762043 PMID:29445054 NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007
JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 decreases activity ISO Mephenytoin results in decreased activity of CYP2C29 protein CTD PMID:18420780 NCBI chr 1:147,236,480...147,307,988 JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 decreases activity ISO Mephenytoin results in decreased activity of CYP2E1 protein CTD PMID:18420780 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Gh1 growth hormone 1 multiple interactions ISO GH1 protein inhibits the reaction [CYP2C19 protein results in increased metabolism of Mephenytoin] CTD PMID:11907490 NCBI chr10:94,486,204...94,488,181
Ensembl chr10:94,486,205...94,488,180
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO Mephenytoin binds to and results in increased activity of NR1I2 protein CTD PMID:15039302 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
nitrofurantoin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 multiple interactions
decreases activity
ISO Nitrofurantoin inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
Nitrofurantoin results in decreased activity of ABCB11 protein
CTD PMID:24014644 NCBI chr 3:55,480,024...55,587,946
Ensembl chr 3:55,480,024...55,587,946
JBrowse link
G Abcb4 ATP binding cassette subfamily B member 4 decreases activity ISO Nitrofurantoin results in decreased activity of ABCB4 protein CTD PMID:28437613 NCBI chr 4:22,133,984...22,192,687
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 affects transport
affects abundance
multiple interactions
increases secretion
increases transport
affects response to substance
increases export
ISO
EXP
ABCG2 protein affects the transport of Nitrofurantoin
ABCG2 protein affects the abundance of Nitrofurantoin
chrysin inhibits the reaction [ABCG2 protein affects the transport of Nitrofurantoin]; Elacridar inhibits the reaction [ABCG2 protein affects the transport of Nitrofurantoin]
ABCG2 protein results in increased secretion of Nitrofurantoin
ABCG2 protein results in increased transport of Nitrofurantoin
ABCG2 results in increased secretion of Nitrofurantoin
chrysin inhibits the reaction [ABCG2 protein results in increased transport of Nitrofurantoin]
ABCG2 affects the susceptibility to Nitrofurantoin
chrysin inhibits the reaction [ABCG2 protein results in increased transport of Nitrofurantoin]; Nitrofurantoin inhibits the reaction [ABCG2 protein results in increased export of bisbenzimide ethoxide trihydrochloride]
ABCG2 protein results in increased export of Nitrofurantoin
CTD PMID:15709111 PMID:15722455 PMID:17093006 PMID:17785426 PMID:18799806 PMID:19105722 PMID:19732493 PMID:26907376 NCBI chr 4:88,765,441...88,890,268
Ensembl chr 4:88,832,178...88,890,621
JBrowse link
G Agt angiotensinogen decreases activity EXP Nitrofurantoin results in decreased activity of AGT protein CTD PMID:1313237 NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433
JBrowse link
G Aldoa aldolase, fructose-bisphosphate A increases expression EXP Nitrofurantoin results in increased expression of ALDOA mRNA; Nitrofurantoin results in increased expression of ALDOA protein CTD PMID:11841787 NCBI chr 1:198,228,387...198,233,988
Ensembl chr 1:198,228,387...198,233,588
JBrowse link
G Cat catalase decreases activity ISO
EXP
Nitrofurantoin results in decreased activity of CAT protein CTD PMID:1313237 PMID:9000262 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Cntf ciliary neurotrophic factor multiple interactions ISO Nitrofurantoin inhibits the reaction [CNTF protein results in increased phosphorylation of and results in increased activity of STAT1 protein]; Nitrofurantoin inhibits the reaction [CNTF protein results in increased phosphorylation of and results in increased activity of STAT3 protein]; Rotenone promotes the reaction [Nitrofurantoin inhibits the reaction [CNTF protein results in increased phosphorylation of and results in increased activity of STAT1 protein]]; Rotenone promotes the reaction [Nitrofurantoin inhibits the reaction [CNTF protein results in increased phosphorylation of and results in increased activity of STAT3 protein]] CTD PMID:15748169 NCBI chr 1:229,599,009...229,601,032
Ensembl chr 1:229,599,009...229,601,032
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO
EXP
Nitrofurantoin inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein] CTD PMID:18493746 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions ISO Nitrofurantoin inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A2 protein] CTD PMID:18493746 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Gsr glutathione-disulfide reductase decreases activity
multiple interactions
EXP
ISO
Nitrofurantoin results in decreased activity of GSR protein
[Nitrofurantoin co-treated with GSR protein] affects the metabolism of Glucose
CTD PMID:1313237 PMID:1901343 PMID:9000262 NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha increases activity EXP Nitrofurantoin results in increased activity of HIF1A protein CTD PMID:11841787 NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052
JBrowse link
G Hmox1 heme oxygenase 1 increases expression EXP Nitrofurantoin results in increased expression of HMOX1 mRNA CTD PMID:7626009 PMID:11841787 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hspa8 heat shock protein family A (Hsp70) member 8 increases expression EXP Nitrofurantoin results in increased expression of HSPA8 mRNA CTD PMID:7626009 NCBI chr 8:44,989,401...44,993,261
Ensembl chr 8:44,990,014...44,993,179
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit increases expression EXP Nitrofurantoin results in increased expression of JUN mRNA CTD PMID:7626009 PMID:11841787 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Lmcd1 LIM and cysteine-rich domains 1 increases expression EXP Nitrofurantoin results in increased expression of LMCD1 mRNA CTD PMID:23558518 NCBI chr 4:144,192,989...144,252,554
Ensembl chr 4:144,192,989...144,252,551
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases response to substance
affects reduction
ISO NQO1 protein results in increased susceptibility to Nitrofurantoin
NQO1 protein affects the reduction of Nitrofurantoin
CTD PMID:9310146 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Orm1 orosomucoid 1 increases expression EXP Nitrofurantoin results in increased expression of ORM1 mRNA; Nitrofurantoin results in increased expression of ORM1 protein CTD PMID:11841787 NCBI chr 5:79,179,668...79,182,820
Ensembl chr 5:79,179,417...79,182,820
JBrowse link
G Por cytochrome p450 oxidoreductase increases metabolic processing
multiple interactions
affects metabolic processing
ISO
EXP
POR protein results in increased metabolism of Nitrofurantoin
diphenyleneiodonium inhibits the reaction [POR protein affects the metabolism of Nitrofurantoin]; NADP affects the reaction [POR protein affects the metabolism of Nitrofurantoin]; Nitrofurantoin inhibits the reaction [POR protein results in increased metabolism of Misonidazole]
CTD PMID:6802140 PMID:18206659 NCBI chr12:23,998,411...24,017,063
Ensembl chr12:23,998,411...24,046,814
JBrowse link
G Stat1 signal transducer and activator of transcription 1 multiple interactions ISO Nitrofurantoin inhibits the reaction [CNTF protein results in increased phosphorylation of and results in increased activity of STAT1 protein]; Rotenone promotes the reaction [Nitrofurantoin inhibits the reaction [CNTF protein results in increased phosphorylation of and results in increased activity of STAT1 protein]] CTD PMID:15748169 NCBI chr 9:54,287,540...54,327,958
Ensembl chr 9:54,287,541...54,484,533
JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions
increases activity
increases expression
ISO
EXP
Nitrofurantoin inhibits the reaction [CNTF protein results in increased phosphorylation of and results in increased activity of STAT3 protein]; Rotenone promotes the reaction [Nitrofurantoin inhibits the reaction [CNTF protein results in increased phosphorylation of and results in increased activity of STAT3 protein]]
Nitrofurantoin results in increased activity of STAT3 protein
Nitrofurantoin results in increased expression of STAT3 mRNA
CTD PMID:11841787 PMID:15748169 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233
JBrowse link
G Tgfb2 transforming growth factor, beta 2 increases expression EXP Nitrofurantoin results in increased expression of TGFB2 mRNA CTD PMID:23558518 NCBI chr13:105,039,639...105,142,010
Ensembl chr13:105,039,853...105,141,030
JBrowse link
phenytoin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aaas aladin WD repeat nucleoporin decreases expression EXP Phenytoin results in decreased expression of AAAS mRNA CTD PMID:20345932 NCBI chr 7:143,937,198...143,956,668
Ensembl chr 7:143,937,199...143,956,668
JBrowse link
G Abca1 ATP binding cassette subfamily A member 1 decreases expression ISO Phenytoin results in decreased expression of ABCA1 mRNA CTD PMID:15136057 NCBI chr 5:69,857,717...69,983,042
Ensembl chr 5:69,857,771...69,983,015
JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A affects response to substance
multiple interactions
increases expression
increases transport
decreases activity
increases metabolic processing
affects abundance
ISO
EXP
ABCB1 protein affects the susceptibility to Phenytoin
Amino Acids, Peptides, and Proteins inhibits the reaction [Phenytoin results in increased expression of ABCB1 protein]; Phenytoin results in increased expression of and results in increased activity of ABCB1A protein
ABCB1A protein results in increased transport of Phenytoin
Phenytoin results in decreased activity of ABCB1 protein
ABCB1 protein results in increased metabolism of Phenytoin
ABCB1 protein affects the abundance of Phenytoin
CTD PMID:8001500 PMID:10580886 PMID:14749549 PMID:15569486 PMID:16220110 PMID:17045309 PMID:17376120 PMID:17529887 PMID:18408562 PMID:18440557 PMID:18473823 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcb1b ATP-binding cassette, subfamily B (MDR/TAP), member 1B affects abundance ISO ABCB1B protein affects the abundance of Phenytoin CTD PMID:12122045 NCBI chr 4:22,225,123...22,307,577
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 multiple interactions
increases expression
EXP KN 62 inhibits the reaction [Phenytoin results in increased expression of ABCC1 protein]; Tetradecanoylphorbol Acetate inhibits the reaction [Phenytoin results in increased expression of ABCC1 protein] CTD PMID:18473823 NCBI chr10:549,537...672,235
Ensembl chr10:549,883...672,196
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 affects transport
multiple interactions
increases expression
affects response to substance
EXP
ISO
ABCC2 protein affects the transport of Phenytoin
KN 62 inhibits the reaction [Phenytoin results in increased expression of ABCC2 protein]; Tetradecanoylphorbol Acetate inhibits the reaction [Phenytoin results in increased expression of ABCC2 protein]
ABCC2 protein affects the susceptibility to Phenytoin
CTD PMID:12663688 PMID:14636316 PMID:17376120 PMID:18473823 NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252
JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 increases expression EXP Phenytoin results in increased expression of ABCC3 mRNA CTD PMID:17381134 NCBI chr10:82,047,308...82,116,928
Ensembl chr10:82,047,863...82,117,109
JBrowse link
G Abcg1 ATP binding cassette subfamily G member 1 decreases expression ISO Phenytoin results in decreased expression of ABCG1 mRNA CTD PMID:15136057 NCBI chr20:9,743,269...9,842,735
Ensembl chr20:9,743,269...9,840,489
JBrowse link
G Abhd5 abhydrolase domain containing 5, lysophosphatidic acid acyltransferase increases expression EXP Phenytoin results in increased expression of ABHD5 mRNA CTD PMID:20345932 NCBI chr 8:130,973,222...131,001,448
Ensembl chr 8:130,973,201...131,001,458
JBrowse link
G Ablim1 actin-binding LIM protein 1 decreases expression ISO Phenytoin results in decreased expression of ABLIM1 mRNA CTD PMID:15136057 NCBI chr 1:277,853,877...278,043,096 JBrowse link
G Ache acetylcholinesterase increases activity ISO Phenytoin results in increased activity of ACHE protein CTD PMID:16946593 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
JBrowse link
G Adam8 ADAM metallopeptidase domain 8 decreases expression ISO Phenytoin results in decreased expression of ADAM8 mRNA CTD PMID:14741686 NCBI chr 1:212,317,510...212,332,895
Ensembl chr 1:212,317,848...212,330,349
JBrowse link
G Adamts9 ADAM metallopeptidase with thrombospondin type 1 motif, 9 increases expression EXP Phenytoin results in increased expression of ADAMTS9 mRNA CTD PMID:20345932 NCBI chr 4:124,660,254...124,860,997
Ensembl chr 4:124,660,262...124,858,250
JBrowse link
G Adgrb3 adhesion G protein-coupled receptor B3 increases expression EXP Phenytoin results in increased expression of ADGRB3 mRNA CTD PMID:20345932 NCBI chr 9:31,280,623...32,022,535
Ensembl chr 9:31,281,316...32,019,205
JBrowse link
G Adrb3 adrenoceptor beta 3 decreases expression EXP Phenytoin results in decreased expression of ADRB3 mRNA CTD PMID:20345932 NCBI chr16:69,003,541...69,006,632
Ensembl chr16:69,003,868...69,006,632
JBrowse link
G Afp alpha-fetoprotein decreases expression ISO Phenytoin results in decreased expression of AFP mRNA CTD PMID:14741686 PMID:26272751 NCBI chr14:19,141,755...19,159,919
Ensembl chr14:19,141,755...19,159,923
JBrowse link
G Agap3 ArfGAP with GTPase domain, ankyrin repeat and PH domain 3 decreases expression EXP Phenytoin results in decreased expression of AGAP3 mRNA CTD PMID:20345932 NCBI chr 4:7,202,330...7,253,386
Ensembl chr 4:7,202,330...7,253,072
JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions
increases expression
ISO
EXP
CYP3A11 protein affects the reaction [Phenytoin results in increased expression of AHR mRNA]
Ketoconazole inhibits the reaction [Phenytoin results in increased expression of AHR protein]
CTD PMID:17505019 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Akap10 A-kinase anchoring protein 10 increases expression EXP Phenytoin results in increased expression of AKAP10 mRNA CTD PMID:20345932 NCBI chr10:48,150,902...48,210,074
Ensembl chr10:48,150,902...48,210,074
JBrowse link
G Akr7a3 aldo-keto reductase family 7 member A3 decreases expression
increases expression
EXP Phenytoin results in decreased expression of AKR7A3 mRNA
Phenytoin results in increased expression of AKR7A3 mRNA
CTD PMID:17381134 NCBI chr 5:157,801,120...157,813,756
Ensembl chr 5:157,801,163...157,813,756
JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 increases expression EXP Phenytoin results in increased expression of ALDH1A1 mRNA CTD PMID:17381134 NCBI chr 1:238,222,689...238,264,381
Ensembl chr 1:238,222,521...238,264,330
JBrowse link
G Aldh1a2 aldehyde dehydrogenase 1 family, member A2 decreases expression ISO Phenytoin results in decreased expression of ALDH1A2 mRNA CTD PMID:31711903 NCBI chr 8:77,640,234...77,719,488
Ensembl chr 8:77,640,222...77,719,489
JBrowse link
G Amn1 antagonist of mitotic exit network 1 homolog increases expression EXP Phenytoin results in increased expression of AMN1 mRNA CTD PMID:20345932 NCBI chr 4:183,670,589...183,697,531
Ensembl chr 4:183,670,596...183,697,531
JBrowse link
G Anxa4 annexin A4 increases expression ISO Phenytoin results in increased expression of ANXA4 mRNA CTD PMID:14741686 NCBI chr 4:118,538,775...118,595,591
Ensembl chr 4:118,538,777...118,595,580
JBrowse link
G Anxa5 annexin A5 multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of ANXA5 mRNA CTD PMID:21224054 NCBI chr 2:123,162,477...123,194,730
Ensembl chr 2:123,162,461...123,193,130
JBrowse link
G Apoa1 apolipoprotein A1 increases expression ISO Phenytoin results in increased expression of APOA1 mRNA CTD PMID:15136057 NCBI chr 8:50,525,091...50,526,875
Ensembl chr 8:50,525,091...50,526,875
JBrowse link
G Apoa4 apolipoprotein A4 increases expression ISO Phenytoin results in increased expression of APOA4 mRNA CTD PMID:15136057 NCBI chr 8:50,536,983...50,539,371
Ensembl chr 8:50,537,009...50,539,376
JBrowse link
G Apoe apolipoprotein E increases expression ISO Phenytoin results in increased expression of APOE mRNA CTD PMID:15136057 NCBI chr 1:80,612,894...80,616,820
Ensembl chr 1:80,612,895...80,617,057
JBrowse link
G Ar androgen receptor multiple interactions
increases expression
increases activity
ISO
EXP
[Phenytoin co-treated with Prednisolone] results in increased expression of AR protein
Phenytoin results in increased expression of AR protein
Ketoconazole inhibits the reaction [Phenytoin results in increased expression of AR protein]
Phenytoin results in increased expression of AR mRNA; Phenytoin results in increased expression of AR protein
Phenytoin results in increased activity of AR protein
CTD PMID:19226368 PMID:19490052 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Arfip1 ADP-ribosylation factor interacting protein 1 increases expression EXP Phenytoin results in increased expression of ARFIP1 mRNA CTD PMID:20345932 NCBI chr 2:183,503,250...183,582,798
Ensembl chr 2:183,504,330...183,582,553
JBrowse link
G Arhgap39 Rho GTPase activating protein 39 increases expression EXP Phenytoin results in increased expression of ARHGAP39 mRNA CTD PMID:20345932 NCBI chr 7:117,788,716...117,880,329
Ensembl chr 7:117,788,716...117,880,289
JBrowse link
G Armc8 armadillo repeat containing 8 increases expression EXP Phenytoin results in increased expression of ARMC8 mRNA CTD PMID:20345932 NCBI chr 8:107,723,359...107,819,208
Ensembl chr 8:107,723,359...107,819,050
JBrowse link
G Atm ATM serine/threonine kinase multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of ATM mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of ATM protein CTD PMID:21224054 NCBI chr 8:58,015,938...58,119,973
Ensembl chr 8:58,015,940...58,120,045
JBrowse link
G Atpaf1 ATP synthase mitochondrial F1 complex assembly factor 1 decreases expression EXP Phenytoin results in decreased expression of ATPAF1 mRNA CTD PMID:20345932 NCBI chr 5:134,641,618...134,667,079
Ensembl chr 5:134,641,608...134,667,084
JBrowse link
G B4galt7 beta-1,4-galactosyltransferase 7 decreases expression EXP Phenytoin results in decreased expression of B4GALT7 mRNA CTD PMID:20345932 NCBI chr17:9,549,605...9,558,672
Ensembl chr17:9,550,028...9,558,634
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of BAX mRNA CTD PMID:21224054 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression
ISO Phenytoin results in increased expression of and affects the localization of BCL2 protein
Phenytoin results in decreased expression of BCL2 mRNA
CTD PMID:9118846 PMID:10695937 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of BCL2L1 mRNA CTD PMID:21224054 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Bmp1 bone morphogenetic protein 1 decreases expression ISO Phenytoin results in decreased expression of BMP1 mRNA CTD PMID:14741686 NCBI chr15:52,166,401...52,210,786
Ensembl chr15:52,166,401...52,210,746
JBrowse link
G Bmp4 bone morphogenetic protein 4 increases expression ISO Phenytoin results in increased expression of BMP4 mRNA CTD PMID:16141649 NCBI chr15:20,776,060...20,791,013
Ensembl chr15:20,776,054...20,822,740
JBrowse link
G C2 complement C2 decreases expression EXP Phenytoin results in decreased expression of C2 mRNA CTD PMID:20345932 NCBI chr20:4,542,340...4,561,152
Ensembl chr20:4,542,340...4,561,152
JBrowse link
G Ca6 carbonic anhydrase 6 increases expression EXP Phenytoin results in increased expression of CAR6 mRNA CTD PMID:20345932 NCBI chr 5:167,226,246...167,244,786
Ensembl chr 5:167,226,246...167,244,786
JBrowse link
G Cacybp calcyclin binding protein increases expression EXP Phenytoin results in increased expression of CACYBP mRNA CTD PMID:20345932 NCBI chr13:77,948,771...77,959,089
Ensembl chr13:77,948,771...77,959,110
JBrowse link
G Calca calcitonin-related polypeptide alpha decreases expression EXP Phenytoin results in decreased expression of CALCA protein CTD PMID:2470235 NCBI chr 1:184,184,018...184,188,922
Ensembl chr 1:184,184,020...184,188,911
JBrowse link
G Calm2 calmodulin 2 decreases expression ISO Phenytoin results in decreased expression of CALM2 mRNA CTD PMID:14741686 NCBI chr 6:11,067,675...11,080,078
Ensembl chr15:65,506,874...65,507,968
JBrowse link
G Capn5 calpain 5 decreases expression ISO Phenytoin results in decreased expression of CAPN5 mRNA CTD PMID:14741686 NCBI chr 1:163,073,134...163,129,736
Ensembl chr 1:163,073,124...163,129,641
JBrowse link
G Caskin1 CASK interacting protein 1 affects expression EXP Phenytoin affects the expression of CASKIN1 mRNA CTD PMID:20345932 NCBI chr10:13,853,107...13,874,254
Ensembl chr10:13,854,339...13,874,254
JBrowse link
G Cat catalase decreases response to substance ISO CAT protein results in decreased susceptibility to Phenytoin CTD PMID:21252394 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Cbll1 Cbl proto-oncogene like 1 increases expression EXP Phenytoin results in increased expression of CBLL1 mRNA CTD PMID:20345932 NCBI chr 6:50,772,718...50,786,861
Ensembl chr 6:50,772,829...50,786,967
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases expression EXP Phenytoin results in increased expression of CCL2 protein CTD PMID:14578793 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccnc cyclin C increases expression EXP Phenytoin results in increased expression of CCNC mRNA CTD PMID:20345932 NCBI chr 5:35,865,598...35,883,732
Ensembl chr 5:35,865,605...35,883,706
JBrowse link
G Ccnd1 cyclin D1 multiple interactions
decreases expression
ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of CCND1 mRNA
Phenytoin results in decreased expression of CCND1 mRNA
CTD PMID:14741686 PMID:21224054 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Ccng1 cyclin G1 multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of CCNG1 mRNA CTD PMID:21224054 NCBI chr10:25,903,925...25,910,298
Ensembl chr10:25,903,911...25,910,325
JBrowse link
G Cd47 Cd47 molecule decreases expression EXP Phenytoin results in decreased expression of CD47 mRNA CTD PMID:17381134 NCBI chr11:53,511,485...53,575,754
Ensembl chr11:53,514,595...53,575,175
JBrowse link
G Cdh2 cadherin 2 decreases expression ISO Phenytoin results in decreased expression of CDH2 mRNA CTD PMID:9118846 NCBI chr18:8,146,971...8,366,037
Ensembl chr18:8,146,971...8,360,684
JBrowse link
G Cdk1 cyclin-dependent kinase 1 decreases expression ISO Phenytoin results in decreased expression of CDK1 mRNA CTD PMID:26272751 NCBI chr20:20,576,341...20,591,510
Ensembl chr20:20,576,377...20,591,549
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A decreases expression
multiple interactions
ISO Phenytoin results in decreased expression of CDKN1A mRNA
[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of CDKN1A mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of CDKN1A protein
CTD PMID:14741686 PMID:21224054 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cdx2 caudal type homeo box 2 increases expression EXP Phenytoin results in increased expression of CDX2 mRNA CTD PMID:20345932 NCBI chr12:9,464,026...9,470,565
Ensembl chr12:9,464,026...9,470,565
JBrowse link
G Cela2a chymotrypsin like elastase 2A decreases expression ISO Phenytoin results in decreased expression of CELA2A mRNA CTD PMID:14741686 NCBI chr 5:160,374,031...160,383,782
Ensembl chr 5:160,374,031...160,383,782
JBrowse link
G Cep57 centrosomal protein 57 increases expression EXP Phenytoin results in increased expression of CEP57 mRNA CTD PMID:20345932 NCBI chr 8:12,335,430...12,355,425
Ensembl chr 8:12,335,432...12,355,091
JBrowse link
G Cer1 cerberus 1, DAN family BMP antagonist decreases expression ISO Phenytoin results in decreased expression of CER1 mRNA CTD PMID:26272751 NCBI chr 5:101,003,019...101,006,375
Ensembl chr 5:101,003,023...101,006,375
JBrowse link
G Chek2 checkpoint kinase 2 multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of CHEK2 mRNA CTD PMID:21224054 NCBI chr12:51,845,574...51,878,098
Ensembl chr12:51,845,796...51,877,624
JBrowse link
G Ckm creatine kinase, M-type increases expression ISO Phenytoin results in increased expression of CKM protein CTD PMID:6682525 NCBI chr 1:80,321,507...80,331,841
Ensembl chr 1:80,321,585...80,331,841
JBrowse link
G Clcn6 chloride voltage-gated channel 6 decreases expression EXP Phenytoin results in decreased expression of CLCN6 mRNA CTD PMID:20345932 NCBI chr 5:164,811,815...164,844,554
Ensembl chr 5:164,811,816...164,844,586
JBrowse link
G Cmpk1 cytidine/uridine monophosphate kinase 1 increases expression EXP Phenytoin results in increased expression of CMPK1 mRNA CTD PMID:20345932 NCBI chr 5:133,759,722...133,786,452
Ensembl chr 5:133,759,735...133,786,452
JBrowse link
G Cnot7 CCR4-NOT transcription complex, subunit 7 increases expression EXP Phenytoin results in increased expression of CNOT7 mRNA CTD PMID:20345932 NCBI chr16:54,899,452...54,918,616
Ensembl chr16:54,899,452...54,918,613
JBrowse link
G Col11a1 collagen type XI alpha 1 chain increases expression ISO Phenytoin results in increased expression of COL11A1 mRNA CTD PMID:14741686 NCBI chr 2:216,863,423...217,056,523
Ensembl chr 2:216,863,428...217,056,523
JBrowse link
G Col18a1 collagen type XVIII alpha 1 chain decreases expression ISO Phenytoin results in decreased expression of COL18A1 mRNA CTD PMID:14741686 NCBI chr20:12,225,202...12,332,858
Ensembl chr20:12,225,202...12,332,858
JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions
increases expression
decreases expression
ISO Phenytoin inhibits the reaction [IL1B protein results in decreased expression of COL1A1 mRNA]
Phenytoin results in increased expression of COL1A1 mRNA
Phenytoin results in decreased expression of COL1A1 mRNA
CTD PMID:8971655 PMID:14741686 NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789
JBrowse link
G Col1a2 collagen type I alpha 2 chain increases expression
affects expression
ISO Phenytoin results in increased expression of COL1A2 mRNA
Phenytoin affects the expression of COL1A2 mRNA
CTD PMID:14741686 PMID:24704097 NCBI chr 4:31,534,225...31,569,152
Ensembl chr 4:31,534,225...31,569,151
JBrowse link
G Col6a1 collagen type VI alpha 1 chain decreases expression
increases expression
ISO Phenytoin results in decreased expression of COL6A1 mRNA
Phenytoin results in increased expression of COL6A1 mRNA
CTD PMID:8224229 PMID:14741686 NCBI chr20:12,657,913...12,676,370
Ensembl chr20:12,658,065...12,675,561
JBrowse link
G Col6a2 collagen type VI alpha 2 chain increases expression ISO Phenytoin results in increased expression of COL6A2 mRNA CTD PMID:8224229 NCBI chr20:12,773,472...12,801,179
Ensembl chr20:12,773,427...12,801,180
JBrowse link
G Col6a3 collagen type VI alpha 3 chain increases expression ISO Phenytoin results in increased expression of COL6A3 mRNA CTD PMID:8224229 NCBI chr 9:97,926,784...98,004,643
Ensembl chr 9:97,926,787...98,004,546
JBrowse link
G Cp ceruloplasmin decreases expression EXP Phenytoin results in decreased expression of CP mRNA CTD PMID:17381134 NCBI chr 2:104,744,249...104,803,034
Ensembl chr 2:104,744,461...104,799,853
JBrowse link
G Cpsf6 cleavage and polyadenylation specific factor 6 increases expression EXP Phenytoin results in increased expression of CPSF6 mRNA CTD PMID:20345932 NCBI chr 7:60,385,688...60,417,661
Ensembl chr 7:60,385,688...60,416,925
JBrowse link
G Crh corticotropin releasing hormone affects expression EXP Phenytoin affects the expression of CRH mRNA CTD PMID:20345932 NCBI chr 2:104,459,999...104,461,863
Ensembl chr 2:104,459,999...104,461,863
JBrowse link
G Crppa CDP-L-ribitol pyrophosphorylase A increases expression EXP Phenytoin results in increased expression of CRPPA mRNA CTD PMID:20345932 NCBI chr 6:55,880,136...56,159,466
Ensembl chr 6:55,881,387...56,159,464
JBrowse link
G Ctsb cathepsin B increases expression
decreases activity
ISO Phenytoin results in increased expression of CTSB mRNA
Phenytoin results in decreased activity of CTSB protein
CTD PMID:10914799 PMID:14741686 NCBI chr15:46,316,741...46,337,613
Ensembl chr15:46,316,741...46,337,612
JBrowse link
G Ctsl cathepsin L increases expression
decreases activity
ISO Phenytoin results in increased expression of CTSL mRNA
Phenytoin results in decreased activity of CTSL protein
CTD PMID:10914799 NCBI chr17:1,873,105...1,879,266
Ensembl chr17:1,872,848...1,879,279
JBrowse link
G Cul4a cullin 4A increases expression EXP Phenytoin results in increased expression of CUL4A mRNA CTD PMID:20345932 NCBI chr16:81,718,784...81,756,653
Ensembl chr16:81,719,028...81,756,654
JBrowse link
G Cx3cl1 C-X3-C motif chemokine ligand 1 increases expression EXP Phenytoin results in increased expression of CX3CL1 mRNA CTD PMID:20345932 NCBI chr19:10,644,267...10,654,861
Ensembl chr19:10,644,244...10,653,800
JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of CXCL10 mRNA CTD PMID:21224054 NCBI chr14:17,210,733...17,212,930
Ensembl chr14:17,210,733...17,212,930
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 multiple interactions ISO [Phenytoin co-treated with Buthionine Sulfoximine] results in increased expression of CXCL2 mRNA; Alprostadil inhibits the reaction [[Phenytoin co-treated with Buthionine Sulfoximine] results in increased expression of CXCL2 mRNA] CTD PMID:23986454 NCBI chr14:18,731,346...18,733,391
Ensembl chr14:18,731,378...18,733,391
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 decreases activity ISO Phenytoin results in decreased activity of CYP19A1 protein CTD PMID:17959350 NCBI chr 8:58,744,849...58,772,408
Ensembl chr 8:58,744,849...58,772,408
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression EXP
ISO
Phenytoin results in increased expression of CYP1A1 mRNA CTD PMID:9860486 PMID:17381134 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions ISO [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Phenytoin CTD PMID:23397584 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of CYP1B1 mRNA CTD PMID:21224054 NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722
JBrowse link
G Cyp2a3 cytochrome P450, family 2, subfamily a, polypeptide 3 multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of CYP2A5 mRNA CTD PMID:21224054 NCBI chr 1:83,653,248...83,662,118
Ensembl chr 1:83,653,234...83,766,484
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 decreases expression
increases expression
multiple interactions
EXP
ISO
Phenytoin results in decreased expression of CYP2B1 mRNA
Phenytoin results in decreased expression of CYP2B10 protein
Phenytoin results in increased expression of CYP2B1 mRNA
[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of CYP2B10 mRNA
CTD PMID:9819145 PMID:10945841 PMID:19226368 PMID:21224054 NCBI chr 7:99,142,431...99,183,540
Ensembl chr 7:99,142,450...99,181,783
JBrowse link
G Cyp2b2 cytochrome P450, family 2, subfamily b, polypeptide 2 increases expression EXP Phenytoin results in increased expression of CYP2B2 mRNA CTD PMID:10945841 NCBI chr 1:83,103,925...83,119,578
Ensembl chr 1:83,103,925...83,119,193
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 multiple interactions
increases expression
increases activity
ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of CYP2B9 mRNA
Phenytoin results in increased expression of CYP2B9 protein
Phenytoin results in increased expression of CYP2B6 mRNA; Phenytoin results in increased expression of CYP2B6 protein
Phenytoin results in increased activity of CYP2B6 protein
[Phenytoin results in increased activity of NR1I3 protein alternative form] which results in increased expression of CYP2B6 mRNA; Dexamethasone promotes the reaction [NR3C1 protein affects the reaction [NR1I2 protein promotes the reaction [Phenytoin results in increased expression of CYP2B6 mRNA]]]; N-(3-(aminomethyl)benzyl)acetamidine inhibits the reaction [Phenytoin results in increased expression of CYP2B6 mRNA]; NOC 18 inhibits the reaction [Phenytoin results in increased expression of CYP2B6 protein]; NR1I2 protein affects the reaction [Phenytoin results in increased expression of and results in increased activity of CYP2B6 protein]; NR1I2 protein promotes the reaction [Phenytoin results in increased expression of CYP2B6 mRNA]; NR1I3 protein affects the reaction [Phenytoin results in increased expression of CYP2B6 mRNA]; Phenytoin results in increased expression of and results in increased activity of CYP2B6 protein; pimagedine inhibits the reaction [Phenytoin results in increased expression of CYP2B6 mRNA]
CTD PMID:12571232 PMID:12695351 PMID:14977870 PMID:15123723 PMID:17041008 PMID:17954527 PMID:18206661 PMID:18332078 PMID:19226368 PMID:19903449 PMID:21224054 PMID:21924250 PMID:23850985 PMID:28289823 NCBI chr 1:83,163,103...83,236,615
Ensembl chr 1:83,163,079...83,236,615
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 multiple interactions
affects metabolic processing
increases metabolic processing
decreases metabolic processing
increases hydroxylation
decreases hydroxylation
ISO
EXP
[CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Phenytoin
CYP2C19 protein affects the metabolism of Phenytoin
CYP2C19 protein results in increased metabolism of Phenytoin
CYP2C19 gene polymorphism results in decreased metabolism of Phenytoin
CYP2C19 protein results in increased hydroxylation of Phenytoin
CYP2C19 gene polymorphism results in decreased hydroxylation of Phenytoin
CTD PMID:9146858 PMID:9333104 PMID:9579299 PMID:9860067 PMID:15569425 PMID:15855726 PMID:16220110 PMID:16789993 PMID:18511451 PMID:23397584 NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007
JBrowse link
G Cyp2c7 cytochrome P450, family 2, subfamily c, polypeptide 7 increases metabolic processing EXP CYP2C9 protein results in increased metabolism of Phenytoin CTD PMID:15569425 NCBI chr 1:147,422,999...148,119,979
Ensembl chr 1:148,053,687...148,119,857
JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 affects expression
increases expression
multiple interactions
ISO Phenytoin affects the expression of CYP2C29 mRNA
Phenytoin results in increased expression of CYP2C protein; Phenytoin results in increased expression of CYP2C29 mRNA; Phenytoin results in increased expression of CYP2C29 protein
[Phenytoin results in decreased activity of CYP2C29 protein] which results in decreased reduction of and results in decreased oxidation of 9-anthraldehyde; NR1I3 protein affects the reaction [Phenytoin results in increased expression of CYP2C29 mRNA]
CTD PMID:12051692 PMID:15155833 PMID:19136022 PMID:19903449 PMID:21766881 NCBI chr 1:147,236,480...147,307,988 JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 multiple interactions ISO [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Phenytoin CTD PMID:23397584 NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions
decreases expression
increases expression
ISO
EXP
NOC 18 inhibits the reaction [Phenytoin results in increased expression of CYP2E1 mRNA]
Phenytoin results in decreased expression of CYP2E1 mRNA
Phenytoin results in increased expression of CYP2E1 mRNA; Phenytoin results in increased expression of CYP2E1 protein
CTD PMID:17381134 PMID:18206661 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases expression
multiple interactions
EXP Phenytoin results in increased expression of CYP3A2 mRNA; Phenytoin results in increased expression of CYP3A2 protein
Ketoconazole inhibits the reaction [Phenytoin results in increased expression of CYP3A2 protein]
CTD PMID:17505019 PMID:19226368 NCBI chr12:11,641,500...11,677,818
Ensembl chr12:11,655,402...11,733,136
JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 decreases expression
increases expression
EXP Phenytoin results in decreased expression of CYP3A23-3A1 mRNA
Phenytoin results in increased expression of CYP3A23-3A1 mRNA
CTD PMID:10945841 PMID:17381134 NCBI chr12:11,053,888...11,082,742
Ensembl chr12:11,655,402...11,733,136
JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 increases expression ISO Phenytoin results in increased expression of CYP3A5 mRNA
Phenytoin results in increased expression of CYP3A13 mRNA
CTD PMID:12673034 PMID:19903449 NCBI chr12:19,074,288...19,114,491
Ensembl chr12:19,074,583...19,114,399
JBrowse link
G Cyp4a1 cytochrome P450, family 4, subfamily a, polypeptide 1 decreases expression EXP Phenytoin results in decreased expression of CYP4A1 mRNA CTD PMID:17381134 NCBI chr 5:134,492,734...134,507,158
Ensembl chr 5:134,492,756...134,507,154
JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of CYP7A1 mRNA CTD PMID:21224054 NCBI chr 5:19,358,734...19,368,431
Ensembl chr 5:19,358,734...19,368,431
JBrowse link
G Cyp7b1 cytochrome P450 family 7 subfamily B member 1 increases expression EXP Phenytoin results in increased expression of CYP7B1 mRNA CTD PMID:20345932 NCBI chr 2:102,701,903...102,871,257
Ensembl chr 2:102,701,903...102,871,257
JBrowse link
G Dap3 death associated protein 3 increases expression ISO Phenytoin results in increased expression of DAP3 mRNA CTD PMID:14741686 NCBI chr 2:188,225,607...188,255,324
Ensembl chr 2:188,225,613...188,252,725
JBrowse link
G Dapk2 death-associated protein kinase 2 decreases expression ISO Phenytoin results in decreased expression of DAPK2 mRNA CTD PMID:14741686 NCBI chr 8:71,822,107...71,941,941
Ensembl chr 8:71,822,129...71,941,910
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of DDIT3 mRNA CTD PMID:21224054 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
JBrowse link
G Dhx9 DExH-box helicase 9 increases expression EXP Phenytoin results in increased expression of DHX9 mRNA CTD PMID:20345932 NCBI chr13:70,885,503...70,922,278
Ensembl chr13:70,885,504...70,922,245
JBrowse link
G Dmtn dematin actin binding protein decreases expression EXP Phenytoin results in decreased expression of DMTN mRNA CTD PMID:20345932 NCBI chr15:52,292,762...52,320,385
Ensembl chr15:52,292,765...52,320,385
JBrowse link
G Dnaja1 DnaJ heat shock protein family (Hsp40) member A1 multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of DNAJA1 mRNA CTD PMID:21224054 NCBI chr 5:57,028,467...57,039,378
Ensembl chr 5:57,028,467...57,039,378
JBrowse link
G E2f1 E2F transcription factor 1 multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of E2F1 mRNA CTD PMID:21224054 NCBI chr 3:150,062,895...150,073,721
Ensembl chr 3:150,047,826...150,073,721
JBrowse link
G Ebpl EBP like increases expression EXP Phenytoin results in increased expression of EBPL mRNA CTD PMID:20345932 NCBI chr15:41,668,119...41,691,518
Ensembl chr15:41,668,119...41,691,518
JBrowse link
G Egr1 early growth response 1 multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of EGR1 mRNA CTD PMID:21224054 NCBI chr18:27,657,903...27,660,101
Ensembl chr18:27,657,628...27,661,429
JBrowse link
G Egr3 early growth response 3 increases expression EXP Phenytoin results in increased expression of EGR3 mRNA CTD PMID:20345932 NCBI chr15:51,756,683...51,762,080
Ensembl chr15:51,756,736...51,760,722
JBrowse link
G Eif1a eukaryotic translation initiation factor 1A increases expression EXP Phenytoin results in increased expression of EIF1A mRNA CTD PMID:20345932 NCBI chr18:40,586,315...40,598,661
Ensembl chr18:40,586,315...40,597,671
JBrowse link
G Emx2 empty spiracles homeobox 2 decreases expression ISO Phenytoin results in decreased expression of EMX2 mRNA CTD PMID:9118846 NCBI chr 1:280,633,938...280,640,946
Ensembl chr 1:280,633,938...280,640,946
JBrowse link
G Enpep glutamyl aminopeptidase decreases expression
increases expression
EXP Phenytoin results in decreased expression of ENPEP mRNA
Phenytoin results in increased expression of ENPEP mRNA
CTD PMID:17381134 NCBI chr 2:233,667,253...233,743,866
Ensembl chr 2:233,667,254...233,743,866
JBrowse link
G Eomes eomesodermin increases expression ISO Phenytoin results in increased expression of EOMES mRNA CTD PMID:14741686 NCBI chr 8:127,144,367...127,152,618
Ensembl chr 8:127,144,903...127,151,493
JBrowse link
G Ephx1 epoxide hydrolase 1 affects response to substance
increases expression
ISO
EXP
EPHX1 gene polymorphism affects the susceptibility to Phenytoin
Phenytoin results in increased expression of EPHX1 mRNA
CTD PMID:17381134 PMID:19952982 NCBI chr13:99,271,390...99,300,580
Ensembl chr13:99,271,366...99,300,579
JBrowse link
G Ephx2 epoxide hydrolase 2 decreases expression EXP Phenytoin results in decreased expression of EPHX2 mRNA CTD PMID:17381134 NCBI chr15:42,757,241...42,794,211
Ensembl chr15:42,757,235...42,794,279
JBrowse link
G Esr1 estrogen receptor 1 increases expression ISO Phenytoin results in increased expression of ESR1 mRNA; Phenytoin results in increased expression of ESR1 protein CTD PMID:19490052 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Eya1 EYA transcriptional coactivator and phosphatase 1 decreases expression ISO Phenytoin results in decreased expression of EYA1 mRNA CTD PMID:31711903 NCBI chr 5:4,275,728...4,495,525
Ensembl chr 5:4,373,626...4,513,142
JBrowse link
G F10 coagulation factor X decreases expression EXP Phenytoin results in decreased expression of F10 mRNA CTD PMID:17381134 NCBI chr16:81,803,169...81,822,476
Ensembl chr16:81,803,110...81,822,716
JBrowse link
G F2 coagulation factor II multiple interactions ISO [clobazam co-treated with Phenytoin] results in increased expression of [F2 protein binds to SERPINC1 protein] CTD PMID:16376047 NCBI chr 3:80,529,468...80,542,993
Ensembl chr 3:80,529,428...80,543,031
JBrowse link
G Faslg Fas ligand multiple interactions
decreases expression
ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of FASL mRNA; [Phenytoin co-treated with Buthionine Sulfoximine] results in decreased expression of FASL mRNA
Phenytoin results in decreased expression of FASL mRNA
CTD PMID:21224054 PMID:23986454 NCBI chr13:79,696,811...79,717,581
Ensembl chr13:79,698,445...79,705,705
JBrowse link
G Fbxl3 F-box and leucine-rich repeat protein 3 increases expression EXP Phenytoin results in increased expression of FBXL3 mRNA CTD PMID:20345932 NCBI chr15:93,647,307...93,667,395
Ensembl chr15:93,647,310...93,667,395
JBrowse link
G Fbxo30 F-box protein 30 increases expression EXP Phenytoin results in increased expression of FBXO30 mRNA CTD PMID:20345932 NCBI chr 1:5,366,119...5,389,774
Ensembl chr 1:5,366,379...5,388,069
JBrowse link
G Fgf12 fibroblast growth factor 12 increases expression EXP Phenytoin results in increased expression of FGF12 mRNA CTD PMID:20345932 NCBI chr11:75,606,360...76,171,078
Ensembl chr11:75,905,443...76,168,989
JBrowse link
G Fgf5 fibroblast growth factor 5 increases expression ISO Phenytoin results in increased expression of FGF5 mRNA CTD PMID:14741686 NCBI chr14:12,974,921...12,996,046
Ensembl chr14:12,974,921...12,995,584
JBrowse link
G Fgf8 fibroblast growth factor 8 increases expression ISO Phenytoin results in increased expression of FGF8 mRNA CTD PMID:31711903 NCBI chr 1:265,492,949...265,498,965
Ensembl chr 1:265,493,124...265,498,831
JBrowse link
G Fgf9 fibroblast growth factor 9 increases expression ISO Phenytoin results in increased expression of FGF9 mRNA CTD PMID:14741686 NCBI chr15:38,341,657...38,386,945
Ensembl chr15:38,341,089...38,387,316
JBrowse link
G Fgfr2 fibroblast growth factor receptor 2 increases expression ISO Phenytoin results in increased expression of FGFR2 mRNA; Phenytoin results in increased expression of FGFR2 protein CTD PMID:11352631 NCBI chr 1:200,590,951...200,696,946
Ensembl chr 1:200,590,953...200,696,928
JBrowse link
G Flrt2 fibronectin leucine rich transmembrane protein 2 increases expression ISO Phenytoin results in increased expression of FLRT2 mRNA CTD PMID:14741686 NCBI chr 6:119,518,459...119,613,534
Ensembl chr 6:119,519,714...119,609,296
JBrowse link
G Fmo1 flavin containing dimethylaniline monoxygenase 1 multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of FMO1 mRNA CTD PMID:21224054 NCBI chr13:80,712,885...80,745,095
Ensembl chr13:80,712,882...80,745,347
JBrowse link
G Fmo4 flavin containing dimethylaniline monoxygenase 4 multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of FMO4 mRNA CTD PMID:21224054 NCBI chr13:80,685,385...80,703,575
Ensembl chr13:80,685,325...80,703,615
JBrowse link
G Fmod fibromodulin decreases expression ISO Phenytoin results in decreased expression of FMOD mRNA CTD PMID:14741686 NCBI chr13:50,874,886...50,885,503
Ensembl chr13:50,873,605...50,885,563
JBrowse link
G Fmr1 FMRP translational regulator 1 increases expression EXP Phenytoin results in increased expression of FMR1 mRNA CTD PMID:20345932 NCBI chr  X:154,684,924...154,722,369
Ensembl chr  X:154,684,935...154,722,314
JBrowse link
G Fn1 fibronectin 1 increases expression ISO Phenytoin results in increased expression of FN1 mRNA CTD PMID:14741686 NCBI chr 9:78,900,111...78,969,018
Ensembl chr 9:78,900,103...78,969,078
JBrowse link
G Fndc3a fibronectin type III domain containing 3a increases expression EXP Phenytoin results in increased expression of FNDC3A mRNA CTD PMID:20345932 NCBI chr15:54,378,865...54,582,954
Ensembl chr15:54,381,044...54,528,480
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions
decreases expression
EXP [Phenytoin co-treated with Drugs, Chinese Herbal] inhibits the reaction [Kainic Acid results in increased expression of FOS mRNA]
Phenytoin results in decreased expression of FOS protein
CTD PMID:7789465 PMID:8758711 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Foxc2 forkhead box C2 decreases expression ISO Phenytoin results in decreased expression of FOXC2 mRNA CTD PMID:31711903 NCBI chr19:53,044,379...53,047,081
Ensembl chr19:53,044,379...53,047,081
JBrowse link
G Foxp3 forkhead box P3 multiple interactions
decreases expression
ISO [Phenytoin co-treated with Buthionine Sulfoximine] results in decreased expression of FOXP3 mRNA
Phenytoin results in decreased expression of FOXP3 mRNA
CTD PMID:23986454 NCBI chr  X:15,753,175...15,768,648
Ensembl chr  X:15,753,175...15,768,522
JBrowse link
G Frs3 fibroblast growth factor receptor substrate 3 decreases expression ISO Phenytoin results in decreased expression of FRS3 mRNA CTD PMID:14741686 NCBI chr 9:15,297,794...15,306,850
Ensembl chr 9:15,297,895...15,306,465
JBrowse link
G G6pc1 glucose-6-phosphatase catalytic subunit 1 decreases expression EXP Phenytoin results in decreased expression of G6PC mRNA CTD PMID:17381134 NCBI chr10:89,286,009...89,296,213
Ensembl chr10:89,285,855...89,296,213
JBrowse link
G G6pd glucose-6-phosphate dehydrogenase affects response to substance ISO G6PDX protein affects the susceptibility to Phenytoin CTD PMID:10627286 NCBI chr  X:156,274,800...156,293,935
Ensembl chr  X:156,274,800...156,293,926
JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of GADD45A mRNA CTD PMID:21224054 NCBI chr 4:97,782,512...97,784,814
Ensembl chr 4:97,782,512...97,784,842
JBrowse link
G Gata3 GATA binding protein 3 multiple interactions
decreases expression
ISO [Phenytoin co-treated with Buthionine Sulfoximine] results in decreased expression of GATA3 mRNA
Phenytoin results in decreased expression of GATA3 mRNA
CTD PMID:23986454 NCBI chr17:72,419,752...72,452,043
Ensembl chr17:72,429,618...72,450,681
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression EXP Phenytoin results in increased expression of GCLM mRNA CTD PMID:20345932 NCBI chr 2:225,827,504...225,847,876
Ensembl chr 2:225,827,504...225,847,874
JBrowse link
G Glul glutamate-ammonia ligase decreases activity ISO Phenytoin results in decreased activity of GLUL protein CTD PMID:10323596 NCBI chr13:71,331,052...71,340,207
Ensembl chr13:71,331,052...71,340,229
JBrowse link
G Gnl2 G protein nucleolar 2 increases expression EXP Phenytoin results in increased expression of GNL2 mRNA CTD PMID:20345932 NCBI chr 5:143,027,970...143,053,418
Ensembl chr 5:143,027,977...143,055,190
JBrowse link
G Gnpda2 glucosamine-6-phosphate deaminase 2 increases expression EXP Phenytoin results in increased expression of GNPDA2 mRNA CTD PMID:20345932 NCBI chr14:62,628,102...62,646,158
Ensembl chr14:62,628,111...62,646,110
JBrowse link
G Gpm6a glycoprotein m6a increases expression EXP Phenytoin results in increased expression of GPM6A mRNA CTD PMID:20345932 NCBI chr16:39,367,697...39,719,292
Ensembl chr16:39,367,692...39,719,187
JBrowse link
G Gpx2 glutathione peroxidase 2 multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of GPX2 mRNA CTD PMID:21224054 NCBI chr 6:99,839,960...99,843,245
Ensembl chr 6:99,839,960...99,843,245
JBrowse link
G Grin1 glutamate ionotropic receptor NMDA type subunit 1 increases expression EXP Phenytoin results in increased expression of GRIN1 mRNA CTD PMID:20345932 NCBI chr 3:2,507,745...2,534,664
Ensembl chr 3:2,506,896...2,534,663
JBrowse link
G Gsta1 glutathione S-transferase alpha 1 increases expression ISO Phenytoin results in increased expression of GSTA1 mRNA CTD PMID:11134551 NCBI chr 9:27,366,404...27,381,004
Ensembl chr 9:27,368,272...27,452,902
JBrowse link
G Gsta2 glutathione S-transferase alpha 2 increases expression
decreases expression
EXP Phenytoin results in increased expression of GSTA2 mRNA
Phenytoin results in decreased expression of GSTA2 mRNA
CTD PMID:17381134 NCBI chr 8:85,640,081...85,645,621 JBrowse link
G Gstk1 glutathione S-transferase kappa 1 decreases expression ISO Phenytoin results in decreased expression of GSTK1 mRNA CTD PMID:14741686 NCBI chr 4:71,621,777...71,626,096
Ensembl chr 4:71,621,729...71,626,107
JBrowse link
G Gstm1 glutathione S-transferase mu 1 increases expression
multiple interactions
EXP
ISO
Phenytoin results in increased expression of GSTM1 mRNA
[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of GSTM1 protein
CTD PMID:17381134 PMID:21224054 NCBI chr 2:210,803,869...210,809,461
Ensembl chr 2:210,803,869...210,809,306
JBrowse link
G Gstm2 glutathione S-transferase mu 2 increases expression EXP Phenytoin results in increased expression of GSTM2 mRNA CTD PMID:17381134 NCBI chr 2:210,778,041...210,782,807
Ensembl chr 2:210,720,704...210,782,856
JBrowse link
G Gstm5 glutathione S-transferase, mu 5 multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of GSTM3 mRNA CTD PMID:21224054 NCBI chr 2:210,685,338...210,688,133
Ensembl chr 2:210,685,197...210,688,272
JBrowse link
G Gsto1 glutathione S-transferase omega 1 decreases expression ISO Phenytoin results in decreased expression of GSTO1 mRNA CTD PMID:14741686 NCBI chr 1:267,607,437...267,617,387
Ensembl chr 1:267,607,418...267,617,387
JBrowse link
G Gusb glucuronidase, beta multiple interactions
decreases activity
ISO Phenytoin inhibits the reaction [Misonidazole results in increased activity of GUSB protein]
Phenytoin results in decreased activity of GUSB protein
CTD PMID:6696821 NCBI chr12:30,202,066...30,215,583
Ensembl chr12:30,198,822...30,227,771
JBrowse link
G Hdac7 histone deacetylase 7 increases expression ISO Phenytoin results in increased expression of HDAC7 mRNA CTD PMID:26272751 NCBI chr 7:139,280,396...139,319,108
Ensembl chr 7:139,281,187...139,318,455
JBrowse link
G Helz helicase with zinc finger increases expression EXP Phenytoin results in increased expression of HELZ mRNA CTD PMID:20345932 NCBI chr10:95,767,754...95,911,025
Ensembl chr10:95,770,154...95,906,927
JBrowse link
G Hexim1 HEXIM P-TEFb complex subunit 1 increases expression EXP Phenytoin results in increased expression of HEXIM1 mRNA CTD PMID:20345932 NCBI chr10:91,200,874...91,202,986
Ensembl chr10:91,200,874...91,202,984
JBrowse link
G Hmgb1 high mobility group box 1 multiple interactions ISO [Phenytoin co-treated with Buthionine Sulfoximine] results in increased secretion of HMGB1 protein CTD PMID:23986454 NCBI chr12:7,082,529...7,090,246
Ensembl chr16:37,500,017...37,502,237
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression
ISO
EXP
[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of HMOX1 mRNA
Phenytoin results in increased expression of HMOX1 mRNA
CTD PMID:17381134 PMID:21224054 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hnrnpa2b1 heterogeneous nuclear ribonucleoprotein A2/B1 increases expression EXP Phenytoin results in increased expression of HNRNPA2B1 mRNA CTD PMID:20345932 NCBI chr 4:81,237,496...81,241,281
Ensembl chr 4:81,237,496...81,241,282
JBrowse link
G Hook3 hook microtubule-tethering protein 3 increases expression EXP Phenytoin results in increased expression of HOOK3 mRNA CTD PMID:20345932 NCBI chr16:70,710,347...70,818,789 JBrowse link
G Hoxa2 homeobox A2 decreases expression ISO Phenytoin results in decreased expression of HOXA2 mRNA; Phenytoin results in decreased expression of HOXA2 protein CTD PMID:10789828 NCBI chr 4:82,130,441...82,134,846
Ensembl chr 4:82,131,329...82,133,605
JBrowse link
G Hoxb7 homeo box B7 increases expression ISO Phenytoin results in increased expression of HOXB7 mRNA CTD PMID:31711903 NCBI chr10:84,135,224...84,138,642
Ensembl chr10:84,135,116...84,138,637
JBrowse link
G Hoxb9 homeo box B9 increases expression ISO Phenytoin results in increased expression of HOXB9 mRNA CTD PMID:31711903 NCBI chr10:84,119,772...84,124,963
Ensembl chr10:84,119,884...84,123,390
JBrowse link
G Hspa1l heat shock protein family A (Hsp70) member 1 like multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of HSPA1L mRNA CTD PMID:21224054 NCBI chr20:4,879,998...4,965,191
Ensembl chr20:4,959,294...4,964,963
JBrowse link
G Hspa8 heat shock protein family A (Hsp70) member 8 multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of HSPA8 mRNA CTD PMID:21224054 NCBI chr 8:44,989,401...44,993,261
Ensembl chr 8:44,990,014...44,993,179
JBrowse link
G Hspb1 heat shock protein family B (small) member 1 multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of HSPB1 mRNA CTD PMID:21224054 NCBI chr12:23,839,390...23,841,051
Ensembl chr12:23,839,399...23,841,049
JBrowse link
G Hspd1 heat shock protein family D (Hsp60) member 1 multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of HSPD1 mRNA CTD PMID:21224054 NCBI chr 9:61,680,529...61,691,202
Ensembl chr 9:61,680,530...61,690,956
JBrowse link
G Hspe1 heat shock protein family E (Hsp10) member 1 multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of HSPE1 mRNA CTD PMID:21224054 NCBI chr 9:61,691,246...61,724,948
Ensembl chr 9:61,692,154...61,694,599
JBrowse link
G Ifng interferon gamma decreases expression ISO Phenytoin results in decreased expression of IFNG protein CTD PMID:10982153 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Ifngr1 interferon gamma receptor 1 increases expression ISO Phenytoin results in increased expression of IFNGR1 mRNA CTD PMID:14741686 NCBI chr 1:15,062,380...15,080,815
Ensembl chr 1:15,062,432...15,080,907
JBrowse link
G Ifngr2 interferon gamma receptor 2 increases expression ISO Phenytoin results in increased expression of IFNGR2 mRNA CTD PMID:14741686 NCBI chr11:31,694,339...31,712,611
Ensembl chr11:31,694,339...31,712,611
JBrowse link
G Igf1 insulin-like growth factor 1 decreases expression EXP Phenytoin results in decreased expression of IGF1 mRNA CTD PMID:17381134 NCBI chr 7:28,412,123...28,491,815
Ensembl chr 7:28,412,198...28,486,609
JBrowse link
G Igf2 insulin-like growth factor 2 increases expression ISO Phenytoin results in increased expression of IGF2 mRNA CTD PMID:9988880 NCBI chr 1:215,828,102...215,839,081
Ensembl chr 1:215,828,102...215,846,911
JBrowse link
G Ihh Indian hedgehog signaling molecule increases expression ISO Phenytoin results in increased expression of IHH mRNA CTD PMID:16141649 NCBI chr 9:82,208,223...82,214,440
Ensembl chr 9:82,208,223...82,214,440
JBrowse link
G Il17a interleukin 17A multiple interactions ISO [Phenytoin co-treated with Buthionine Sulfoximine] results in increased secretion of IL17A protein CTD PMID:23986454 NCBI chr 9:26,841,299...26,844,786
Ensembl chr 9:26,841,299...26,844,786
JBrowse link
G Il18 interleukin 18 multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of IL18 mRNA CTD PMID:21224054 NCBI chr 8:55,009,666...55,016,286
Ensembl chr 8:54,993,859...55,016,299
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Phenytoin inhibits the reaction [IL1B protein results in decreased expression of COL1A1 mRNA]
[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of IL1B mRNA; [Phenytoin co-treated with Buthionine Sulfoximine] results in increased expression of IL1B mRNA; [Phenytoin co-treated with Buthionine Sulfoximine] results in increased secretion of IL1B protein
CTD PMID:8971655 PMID:21224054 PMID:23986454 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il23a interleukin 23 subunit alpha multiple interactions ISO [Phenytoin co-treated with Buthionine Sulfoximine] results in increased expression of IL23A mRNA CTD PMID:23986454 NCBI chr 7:2,710,609...2,712,723
Ensembl chr 7:2,710,609...2,712,723
JBrowse link
G Il6 interleukin 6 multiple interactions
increases expression
ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of IL6 mRNA; [Phenytoin co-treated with Buthionine Sulfoximine] results in increased expression of IL6 mRNA
Phenytoin results in increased expression of IL6 mRNA
CTD PMID:21224054 PMID:23986454 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Il6r interleukin 6 receptor decreases expression ISO Phenytoin results in decreased expression of IL6RA mRNA CTD PMID:15136057 NCBI chr 2:189,196,180...189,255,987
Ensembl chr 2:189,205,701...189,254,628
JBrowse link
G Inpp5f inositol polyphosphate-5-phosphatase F increases expression EXP Phenytoin results in increased expression of INPP5F mRNA CTD PMID:20345932 NCBI chr 1:200,037,749...200,116,524
Ensembl chr 1:200,037,749...200,116,524
JBrowse link
G Insr insulin receptor increases expression ISO Phenytoin results in increased expression of INSR mRNA CTD PMID:14741686 NCBI chr12:1,682,527...1,816,414
Ensembl chr12:1,680,957...1,816,414
JBrowse link
G Ipp intracisternal A particle-promoted polypeptide increases expression EXP Phenytoin results in increased expression of IPP mRNA CTD PMID:20345932 NCBI chr 5:135,351,767...135,390,363
Ensembl chr 5:135,351,816...135,388,083
JBrowse link
G Irf9 interferon regulatory factor 9 increases expression EXP Phenytoin results in increased expression of IRF9 mRNA CTD PMID:20345932 NCBI chr15:34,282,936...34,288,981
Ensembl chr15:34,282,936...34,288,138
JBrowse link
G Itga2 integrin subunit alpha 2 decreases expression ISO Phenytoin results in decreased expression of ITGA2 protein CTD PMID:15948689 NCBI chr 2:46,996,904...47,097,011
Ensembl chr 2:47,000,323...47,096,961
JBrowse link
G Itga8 integrin subunit alpha 8 increases expression ISO Phenytoin results in increased expression of ITGA8 mRNA CTD PMID:14741686 NCBI chr17:79,321,893...79,676,927
Ensembl chr17:79,321,900...79,676,499
JBrowse link
G Itgb1 integrin subunit beta 1 decreases expression ISO Phenytoin results in decreased expression of ITGB1 protein CTD PMID:15948689 NCBI chr19:61,677,512...61,725,537
Ensembl chr19:61,677,542...61,725,535
JBrowse link
G Itgb3bp integrin subunit beta 3 binding protein increases expression EXP Phenytoin results in increased expression of ITGB3BP mRNA CTD PMID:20345932 NCBI chr 5:118,476,410...118,541,928
Ensembl chr 5:118,476,430...118,673,780
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit decreases expression ISO Phenytoin results in decreased expression of JUN mRNA CTD PMID:9118846 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Kcnd2 potassium voltage-gated channel subfamily D member 2 increases expression EXP Phenytoin results in increased expression of KCND2 mRNA CTD PMID:20345932 NCBI chr 4:48,309,283...48,816,804 JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO Phenytoin results in decreased activity of KCNH2 protein CTD PMID:21158687 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253
JBrowse link
G Kctd3 potassium channel tetramerization domain containing 3 increases expression EXP Phenytoin results in increased expression of KCTD3 mRNA CTD PMID:20345932 NCBI chr13:107,433,588...107,471,843
Ensembl chr13:107,433,588...107,471,843
JBrowse link
G Kdr kinase insert domain receptor increases expression ISO Phenytoin results in increased expression of KDR mRNA CTD PMID:26272751 NCBI chr14:34,727,677...34,787,127
Ensembl chr14:34,727,623...34,787,183
JBrowse link
G Khdrbs2 KH RNA binding domain containing, signal transduction associated 2 increases expression EXP Phenytoin results in increased expression of KHDRBS2 mRNA CTD PMID:20345932 NCBI chr 9:39,501,431...40,008,707
Ensembl chr 9:39,539,530...40,008,680
JBrowse link
G Klf2 Kruppel-like factor 2 increases expression EXP Phenytoin results in increased expression of KLF2 mRNA CTD PMID:20345932 NCBI chr16:19,223,087...19,225,037
Ensembl chr16:19,223,087...19,225,037
JBrowse link
G Klhl2 kelch-like family member 2 increases expression EXP Phenytoin results in increased expression of KLHL2 mRNA CTD PMID:20345932 NCBI chr16:26,755,246...26,852,134
Ensembl chr16:26,739,389...26,852,179
JBrowse link
G Klhl7 kelch-like family member 7 increases expression EXP Phenytoin results in increased expression of KLHL7 mRNA CTD PMID:20345932 NCBI chr 4:7,532,881...7,582,032
Ensembl chr 4:7,532,889...7,582,207
JBrowse link
G Krit1 KRIT1, ankyrin repeat containing increases expression EXP Phenytoin results in increased expression of KRIT1 mRNA CTD PMID:20345932 NCBI chr 4:27,438,609...27,473,150
Ensembl chr 4:27,438,609...27,473,150
JBrowse link
G Krt2 keratin 2 increases expression ISO Phenytoin results in increased expression of KRT2 mRNA CTD PMID:14741686 NCBI chr 7:143,412,858...143,420,463
Ensembl chr 7:143,412,858...143,420,027
JBrowse link
G Kyat1 kynurenine aminotransferase 1 increases activity EXP Phenytoin results in increased activity of KYAT1 protein CTD PMID:16765940 NCBI chr 3:8,752,289...8,785,617
Ensembl chr 3:8,752,625...8,766,433
JBrowse link
G Lama2 laminin subunit alpha 2 increases expression EXP Phenytoin results in increased expression of LAMA2 mRNA CTD PMID:20345932 NCBI chr 1:18,491,264...19,143,486
Ensembl chr 1:18,491,384...19,143,269
JBrowse link
G Lap3 leucine aminopeptidase 3 affects expression EXP Phenytoin affects the expression of LAP3 mRNA CTD PMID:20345932 NCBI chr14:70,102,813...70,121,797
Ensembl chr14:70,102,814...70,121,797
JBrowse link
G Lcat lecithin cholesterol acyltransferase increases expression ISO Phenytoin results in increased expression of LCAT mRNA CTD PMID:15136057 NCBI chr19:37,913,333...37,916,799
Ensembl chr19:37,913,336...37,916,813
JBrowse link
G Ldb2 LIM domain binding 2 increases expression EXP Phenytoin results in increased expression of LDB2 mRNA CTD PMID:20345932 NCBI chr14:70,780,605...71,112,857
Ensembl chr14:70,780,623...71,112,552
JBrowse link
G Lpin1 lipin 1 increases expression ISO Phenytoin results in increased expression of LPIN1 mRNA CTD PMID:14741686 NCBI chr 6:41,796,214...41,905,149
Ensembl chr 6:41,799,749...41,870,046
JBrowse link
G Lrba LPS responsive beige-like anchor protein increases expression EXP Phenytoin results in increased expression of LRBA mRNA CTD PMID:20345932 NCBI chr 2:185,590,983...186,110,491
Ensembl chr 2:185,524,774...186,110,495
JBrowse link
G Lsm1 LSM1 homolog, mRNA degradation associated decreases expression EXP Phenytoin results in decreased expression of LSM1 mRNA CTD PMID:20345932 NCBI chr16:71,046,475...71,057,883
Ensembl chr16:71,046,475...71,057,883
JBrowse link
G Ltbp4 latent transforming growth factor beta binding protein 4 increases expression EXP Phenytoin results in increased expression of LTBP4 mRNA CTD PMID:20345932 NCBI chr 1:84,118,046...84,152,095
Ensembl chr 1:84,118,046...84,150,084
JBrowse link
G Lypla1 lysophospholipase 1 increases expression EXP Phenytoin results in increased expression of LYPLA1 mRNA CTD PMID:20345932 NCBI chr 5:14,559,333...14,588,447
Ensembl chr 5:14,559,334...14,588,422
JBrowse link
G Map1b microtubule-associated protein 1B increases expression ISO Phenytoin results in increased expression of MAP1B mRNA CTD PMID:14741686 NCBI chr 2:29,675,391...29,768,750
Ensembl chr 2:29,675,391...29,768,750
JBrowse link
G Map3k4 mitogen activated protein kinase kinase kinase 4 increases expression EXP Phenytoin results in increased expression of MAP3K4 mRNA CTD PMID:20345932 NCBI chr 1:48,625,714...48,711,642
Ensembl chr 1:48,625,743...48,711,642
JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases phosphorylation ISO Phenytoin results in decreased phosphorylation of MAPK1 protein CTD PMID:15948689 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases phosphorylation ISO Phenytoin results in decreased phosphorylation of MAPK3 protein CTD PMID:15948689 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mapre3 microtubule-associated protein, RP/EB family, member 3 increases expression EXP Phenytoin results in increased expression of MAPRE3 mRNA CTD PMID:20345932 NCBI chr 6:26,878,738...26,923,459
Ensembl chr 6:26,878,744...26,889,882
JBrowse link
G Mbl1 mannose binding lectin 1 decreases expression EXP Phenytoin results in decreased expression of MBL1 mRNA CTD PMID:17381134 NCBI chr16:18,736,154...18,742,193
Ensembl chr16:18,736,154...18,742,193
JBrowse link
G Mdk midkine increases expression ISO Phenytoin results in increased expression of MDK mRNA CTD PMID:14741686 NCBI chr 3:80,841,003...80,843,895
Ensembl chr 3:80,841,005...80,842,916
JBrowse link
G Mdm2 MDM2 proto-oncogene multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of MDM2 mRNA CTD PMID:21224054 NCBI chr 7:60,719,060...60,743,618
Ensembl chr 7:60,719,066...60,743,328
JBrowse link
G Me1 malic enzyme 1 increases expression EXP Phenytoin results in increased expression of ME1 mRNA CTD PMID:17381134 NCBI chr 8:94,256,830...94,368,834
Ensembl chr 8:94,256,839...94,368,834
JBrowse link
G Meox1 mesenchyme homeobox 1 decreases expression ISO Phenytoin results in decreased expression of MEOX1 mRNA CTD PMID:31711903 NCBI chr10:89,797,011...89,817,009
Ensembl chr10:89,797,038...89,816,491
JBrowse link
G Mesp1 mesoderm posterior bHLH transcription factor 1 increases expression ISO Phenytoin results in increased expression of MESP1 mRNA CTD PMID:26272751 NCBI chr 1:141,532,390...141,533,908
Ensembl chr 1:141,532,390...141,533,908
JBrowse link
G Mex3d mex-3 RNA binding family member D increases expression EXP Phenytoin results in increased expression of MEX3D mRNA CTD PMID:20345932 NCBI chr 7:12,191,902...12,198,841
Ensembl chr 7:12,192,088...12,198,551
JBrowse link
G Mgat2 alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase increases expression EXP Phenytoin results in increased expression of MGAT2 mRNA CTD PMID:20345932 NCBI chr 6:91,476,698...91,479,187
Ensembl chr 6:91,476,698...91,479,183
JBrowse link
G Mgmt O-6-methylguanine-DNA methyltransferase increases methylation ISO Phenytoin results in increased methylation of MGMT promoter CTD PMID:15949900 NCBI chr 1:209,237,255...209,464,189
Ensembl chr 1:209,237,233...209,464,190
JBrowse link
G Mki67 marker of proliferation Ki-67 multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC gene mutant form] results in increased expression of MKI67 protein CTD PMID:21224054 NCBI chr 1:207,993,895...208,020,454
Ensembl chr 1:207,993,895...208,020,454
JBrowse link
G Mmp1 matrix metallopeptidase 1 decreases expression
increases expression
ISO Phenytoin results in decreased expression of MMP1 mRNA
Phenytoin results in increased expression of MMP1 mRNA
CTD PMID:10914799 PMID:14741686 PMID:15948689 NCBI chr 8:5,703,206...5,723,593
Ensembl chr 8:5,703,206...5,723,591
JBrowse link
G Mmp2 matrix metallopeptidase 2 decreases expression ISO Phenytoin results in decreased expression of MMP2 mRNA CTD PMID:15948689 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
JBrowse link
G Mmp3 matrix metallopeptidase 3 decreases expression ISO Phenytoin results in decreased expression of MMP3 mRNA CTD PMID:15948689 NCBI chr 8:5,676,608...5,698,579
Ensembl chr 8:5,676,665...5,698,579
JBrowse link
G Mrps18c mitochondrial ribosomal protein S18C increases expression EXP Phenytoin results in increased expression of MRPS18C mRNA CTD PMID:20345932 NCBI chr14:10,440,691...10,446,909
Ensembl chr14:10,440,691...10,446,909
JBrowse link
G Mtf2 metal response element binding transcription factor 2 increases expression EXP Phenytoin results in increased expression of MTF2 mRNA CTD PMID:20345932 NCBI chr14:2,656,776...2,701,027
Ensembl chr14:2,658,267...2,700,977
JBrowse link
G Mthfd1l methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like increases expression EXP Phenytoin results in increased expression of MTHFD1L mRNA CTD PMID:20345932 NCBI chr 1:40,529,092...40,719,232
Ensembl chr 1:40,529,045...40,719,391
JBrowse link
G Mtx2 metaxin 2 increases expression EXP Phenytoin results in increased expression of MTX2 mRNA CTD PMID:20345932 NCBI chr 3:61,756,109...61,818,999
Ensembl chr 3:61,756,148...61,818,998
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor increases expression
decreases expression
ISO Phenytoin results in increased expression of MYC protein
Phenytoin results in decreased expression of MYC mRNA
CTD PMID:10695937 PMID:26272751 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
JBrowse link
G Myo1e myosin IE increases expression ISO Phenytoin results in increased expression of MYO1E mRNA CTD PMID:26272751 NCBI chr 8:76,644,715...76,840,240
Ensembl chr 8:76,754,492...76,839,593
JBrowse link
G Nap1l2 nucleosome assembly protein 1-like 2 affects expression EXP Phenytoin affects the expression of NAP1L2 mRNA CTD PMID:20345932 NCBI chr  X:73,997,274...73,999,677 JBrowse link
G Ncan neurocan increases expression ISO Phenytoin results in increased expression of NCAN mRNA CTD PMID:14741686 NCBI chr16:21,050,243...21,076,707
Ensembl chr16:21,050,243...21,076,707
JBrowse link
G Ncl nucleolin decreases expression EXP Phenytoin results in decreased expression of NCL mRNA CTD PMID:17381134 NCBI chr 9:93,369,119...93,377,643
Ensembl chr 9:93,368,932...93,377,643
JBrowse link
G Ncoa1 nuclear receptor coactivator 1 multiple interactions ISO Phenytoin promotes the reaction [NR1I3 protein modified form binds to NCOA1 protein] CTD PMID:21924250 NCBI chr 6:28,677,563...28,931,844
Ensembl chr 6:28,677,540...28,931,843
JBrowse link
G Nelfa negative elongation factor complex member A decreases expression EXP Phenytoin results in decreased expression of NELFA mRNA CTD PMID:20345932 NCBI chr14:82,093,837...82,117,913
Ensembl chr14:82,093,837...82,117,906
JBrowse link
G Nes nestin decreases expression ISO Phenytoin results in decreased expression of NES mRNA CTD PMID:26272751 NCBI chr 2:187,343,109...187,352,972
Ensembl chr 2:187,344,056...187,352,969
JBrowse link
G Neurog2 neurogenin 2 increases expression ISO Phenytoin results in increased expression of NEUROG2 mRNA CTD PMID:31711903 NCBI chr 2:231,962,517...231,963,441
Ensembl chr 2:231,962,517...231,963,308
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions
increases expression
ISO Phenytoin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased localization of and results in increased activity of NFKB1 protein]
Phenytoin results in increased expression of NFKB1 mRNA
CTD PMID:10700573 PMID:14741686 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
JBrowse link
G Nfkbia NFKB inhibitor alpha decreases degradation ISO Phenytoin results in decreased degradation of NFKBIA protein CTD PMID:15948689 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Ngly1 N-glycanase 1 increases expression EXP Phenytoin results in increased expression of NGLY1 mRNA CTD PMID:20345932 NCBI chr15:10,405,453...10,455,973
Ensembl chr15:10,405,164...10,455,956
JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions ISO [Phenytoin co-treated with Buthionine Sulfoximine] results in increased expression of NLRP3 mRNA CTD PMID:23986454 NCBI chr10:45,884,324...45,918,290
Ensembl chr10:45,893,018...45,918,254
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of NOS2 mRNA CTD PMID:21224054 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Npas2 neuronal PAS domain protein 2 increases expression EXP Phenytoin results in increased expression of NPAS2 mRNA CTD PMID:20345932 NCBI chr 9:45,901,262...46,081,880
Ensembl chr 9:45,901,741...46,081,880
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression EXP Phenytoin results in increased expression of NQO1 mRNA CTD PMID:17381134 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions
affects activity
increases expression
increases activity
ISO
EXP
Dexamethasone promotes the reaction [NR3C1 protein affects the reaction [NR1I2 protein promotes the reaction [Phenytoin results in increased expression of CYP2B6 mRNA]]]; N-Methyl-3,4-methylenedioxyamphetamine inhibits the reaction [Phenytoin promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA]]; NR1I2 protein affects the reaction [Phenytoin results in increased expression of and results in increased activity of CYP2B6 protein]; NR1I2 protein affects the reaction [Phenytoin results in increased expression of CYP2C9 mRNA]; NR1I2 protein affects the reaction [Phenytoin results in increased expression of CYP3A4 mRNA]; NR1I2 protein promotes the reaction [Phenytoin results in increased expression of CYP2B6 mRNA]; Phenytoin binds to and results in increased activity of NR1I2 protein; Phenytoin promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA]
Phenytoin affects the activity of NR1I2 protein
Phenytoin results in increased expression of NR1I2 protein
Phenytoin results in increased activity of NR1I2 protein
CTD PMID:12065438 PMID:12695340 PMID:12695351 PMID:14600250 PMID:14977870 PMID:15039302 PMID:18473823 PMID:21402137 PMID:23611293 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions
increases expression
increases activity
increases localization
ISO
EXP
[Phenytoin results in increased activity of NR1I3 protein alternative form] which results in increased expression of CYP2B6 mRNA; NR1I3 protein affects the reaction [Phenytoin results in increased expression of CYP2B6 mRNA]; Phenytoin promotes the reaction [NR1I3 protein modified form binds to NCOA1 protein]
Phenytoin results in increased expression of NR1I3 protein
NR1I3 protein affects the reaction [Phenytoin results in increased expression of CYP2C29 mRNA]; NR1I3 protein affects the reaction [Phenytoin results in increased expression of CYP2C37 mRNA]
Phenytoin results in increased localization of NR1I3 protein
CTD PMID:15123723 PMID:15155833 PMID:15849716 PMID:16936065 PMID:17041008 PMID:18473823 PMID:21924250 NCBI chr13:89,585,072...89,591,278
Ensembl chr13:89,586,283...89,591,277
JBrowse link
G Nr2f1 nuclear receptor subfamily 2, group F, member 1 increases expression EXP Phenytoin results in increased expression of NR2F1 mRNA CTD PMID:20345932 NCBI chr 2:5,569,954...5,579,894
Ensembl chr 2:5,569,935...5,579,894
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 multiple interactions
increases expression
ISO
EXP
Dexamethasone promotes the reaction [NR3C1 protein affects the reaction [NR1I2 protein promotes the reaction [Phenytoin results in increased expression of CYP2B6 mRNA]]]; NR3C1 protein promotes the reaction [Phenytoin results in increased expression of CYP3A4 mRNA]
Phenytoin results in increased expression of NR3C1 mRNA
CTD PMID:10219967 PMID:12695351 PMID:20345932 NCBI chr18:31,728,373...32,704,022
Ensembl chr18:31,728,373...31,749,647
JBrowse link
G Nrcam neuronal cell adhesion molecule decreases expression ISO Phenytoin results in decreased expression of NRCAM mRNA CTD PMID:26272751 NCBI chr 6:64,297,843...64,867,408
Ensembl chr 6:64,297,888...64,864,996
JBrowse link
G Nsmce3 NSE3 homolog, SMC5-SMC6 complex component increases expression EXP Phenytoin results in increased expression of NSMCE3 mRNA CTD PMID:20345932 NCBI chr 1:125,663,987...125,665,314 JBrowse link
G Nt5dc1 5'-nucleotidase domain containing 1 increases expression EXP Phenytoin results in increased expression of NT5DC1 mRNA CTD PMID:20345932 NCBI chr20:41,106,990...41,209,765
Ensembl chr20:41,106,991...41,209,728
JBrowse link
G Ntf3 neurotrophin 3 decreases expression ISO Phenytoin results in decreased expression of NTF3 mRNA CTD PMID:7841657 NCBI chr 4:158,636,883...158,705,886
Ensembl chr 4:158,636,884...158,705,886
JBrowse link
G Nup153 nucleoporin 153 increases expression EXP Phenytoin results in increased expression of NUP153 mRNA CTD PMID:20345932 NCBI chr17:18,358,712...18,411,368
Ensembl chr17:18,358,712...18,411,368
JBrowse link
G Olig3 oligodendrocyte transcription factor 3 increases expression ISO Phenytoin results in increased expression of OLIG3 mRNA CTD PMID:31711903 NCBI chr 1:14,797,766...14,799,835
Ensembl chr 1:14,797,766...14,799,835
JBrowse link
G Oprm1 opioid receptor, mu 1 multiple interactions ISO [cyprodime binds to and results in decreased activity of OPRM1 protein] which results in decreased susceptibility to Phenytoin CTD PMID:7870991 NCBI chr 1:43,454,803...43,704,948
Ensembl chr 1:43,454,803...43,704,948
JBrowse link
G Pafah1b1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 decreases expression ISO Phenytoin results in decreased expression of PAFAH1B1 mRNA CTD PMID:15136057 NCBI chr10:61,456,144...61,577,412
Ensembl chr10:61,456,145...61,577,412
JBrowse link
G Pafah1b2 platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 decreases expression ISO Phenytoin results in decreased expression of PAFAH1B2 mRNA CTD PMID:15136057 NCBI chr 8:50,256,969...50,310,043
Ensembl chr 8:50,259,248...50,277,797
JBrowse link
G Pard6g par-6 family cell polarity regulator gamma increases expression EXP Phenytoin results in increased expression of PARD6G mRNA CTD PMID:20345932 NCBI chr18:76,559,877...76,627,843
Ensembl chr18:76,559,811...76,628,041
JBrowse link
G Parg poly (ADP-ribose) glycohydrolase increases expression EXP Phenytoin results in increased expression of PARG mRNA CTD PMID:20345932 NCBI chr16:8,350,168...8,457,999
Ensembl chr16:8,350,326...8,457,996
JBrowse link
G Pax3 paired box 3 decreases expression ISO Phenytoin results in decreased expression of PAX3 mRNA CTD PMID:9118846 PMID:31711903 NCBI chr 9:84,004,004...84,101,226
Ensembl chr 9:84,005,183...84,101,172
JBrowse link
G Pax6 paired box 6 increases expression ISO Phenytoin results in increased expression of PAX6 mRNA CTD PMID:31711903 NCBI chr 3:95,700,241...95,728,682
Ensembl chr 3:95,707,386...95,728,624
JBrowse link
G Pbx1 PBX homeobox 1 increases expression EXP Phenytoin results in increased expression of PBX1 mRNA CTD PMID:20345932 NCBI chr13:86,390,741...86,671,460
Ensembl chr13:86,390,741...86,451,002
JBrowse link
G Pcyox1 prenylcysteine oxidase 1 increases expression EXP Phenytoin results in increased expression of PCYOX1 mRNA CTD PMID:20345932 NCBI chr 4:118,187,133...118,198,029
Ensembl chr 4:118,187,134...118,198,029
JBrowse link
G Pdgfa platelet derived growth factor subunit A increases expression ISO Phenytoin results in increased expression of PDGFA mRNA CTD PMID:14741686 NCBI chr12:17,734,141...17,756,186
Ensembl chr12:17,734,133...17,755,285
JBrowse link
G Pdgfb platelet derived growth factor subunit B increases expression EXP
ISO
Phenytoin results in increased expression of PDGFB mRNA; Phenytoin results in increased expression of PDGFB protein CTD PMID:8463938 PMID:9029455 PMID:14741686 NCBI chr 7:121,215,458...121,233,092
Ensembl chr 7:121,214,628...121,232,741
JBrowse link
G Pgrmc1 progesterone receptor membrane component 1 increases expression EXP Phenytoin results in increased expression of PGRMC1 mRNA CTD PMID:17381134 NCBI chr  X:123,205,869...123,213,880
Ensembl chr  X:123,205,869...123,213,882
JBrowse link
G Phf14 PHD finger protein 14 increases expression EXP Phenytoin results in increased expression of PHF14 mRNA CTD PMID:20345932 NCBI chr 4:38,241,189...38,420,199
Ensembl chr 4:38,240,728...38,420,205
JBrowse link
G Pip4k2a phosphatidylinositol-5-phosphate 4-kinase type 2 alpha increases expression ISO Phenytoin results in increased expression of PIP4K2A mRNA CTD PMID:14741686 NCBI chr17:85,533,056...85,748,843 JBrowse link
G Plaur plasminogen activator, urokinase receptor decreases expression ISO Phenytoin results in decreased expression of PLAUR mRNA CTD PMID:14741686 NCBI chr 1:81,328,171...81,344,954
Ensembl chr 1:81,328,183...81,344,708
JBrowse link
G Plcl1 phospholipase C-like 1 increases expression EXP Phenytoin results in increased expression of PLCL1 mRNA CTD PMID:20345932 NCBI chr 9:62,016,112...62,349,244
Ensembl chr 9:62,291,405...62,349,309
JBrowse link
G Plec plectin increases expression EXP Phenytoin results in increased expression of PLEC mRNA CTD PMID:20345932 NCBI chr 7:117,230,319...117,291,859
Ensembl chr 7:117,230,319...117,289,961
JBrowse link
G Pltp phospholipid transfer protein increases expression ISO Phenytoin results in increased expression of PLTP mRNA CTD PMID:15136057 NCBI chr 3:161,304,469...161,322,289
Ensembl chr 3:161,304,469...161,322,289
JBrowse link
G Plxnb2 plexin B2 decreases expression ISO Phenytoin results in decreased expression of PLXNB2 mRNA CTD PMID:14741686 NCBI chr 7:130,135,484...130,161,568
Ensembl chr 7:130,135,464...130,151,880
JBrowse link
G Pnn pinin, desmosome associated protein increases expression EXP Phenytoin results in increased expression of PNN mRNA CTD PMID:20345932 NCBI chr 6:80,159,364...80,167,677
Ensembl chr 6:80,159,364...80,167,677
JBrowse link
G Pon1 paraoxonase 1 decreases expression
affects activity
ISO Phenytoin results in decreased expression of PON1 mRNA
Phenytoin affects the activity of PON1 protein
CTD PMID:15136057 PMID:28032682 NCBI chr 4:30,249,749...30,276,297
Ensembl chr 4:30,249,742...30,276,372
JBrowse link
G Por cytochrome p450 oxidoreductase increases activity ISO Phenytoin results in increased activity of POR protein CTD PMID:12051692 NCBI chr12:23,998,411...24,017,063
Ensembl chr12:23,998,411...24,046,814
JBrowse link
G Pou3f1 POU class 3 homeobox 1 increases expression ISO Phenytoin results in increased expression of POU3F1 protein CTD PMID:12781989 NCBI chr 5:142,643,599...142,646,580
Ensembl chr 5:142,643,599...142,646,580
JBrowse link
G Ppil4 peptidylprolyl isomerase like 4 increases expression EXP Phenytoin results in increased expression of PPIL4 mRNA CTD PMID:20345932 NCBI chr 1:1,897,316...1,930,311
Ensembl chr 1:1,897,338...1,929,763
JBrowse link
G Prkdc protein kinase, DNA-activated, catalytic subunit multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC gene mutant form] results in increased expression of MKI67 protein; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of ATM mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of ATM protein; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of CCND1 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of CHEK2 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of CYP1B1 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of CYP2A5 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of CYP2B9 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of CYP4A10 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of CYP4A14 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of CYP7A1 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of DNAJA1 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of EGR1 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of FASL mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of FMO1 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of FMO4 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of HSPD1 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of HSPE1 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of IL18 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of IL1B mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of RAD50 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of TNFSF10 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of TRADD mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of XRCC4 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of ANXA5 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of BAX mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of BCL2L1 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of CCNG1 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of CDKN1A mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of CDKN1A protein; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of CXCL10 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of CYP2B10 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of CYP3A11 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of CYP3A4 protein; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of DDIT3 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of E2F1 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of GADD45A mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of GPX2 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of GSTM1 protein; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of GSTM3 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of HMOX1 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of HSPA1L mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of HSPA8 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of HSPB1 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of IL6 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of MDM2 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of NOS2 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of SERPINE1 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of UNG mRNA; PRKDC gene mutant form results in increased susceptibility to [Rifampin co-treated with Phenytoin co-treated with Monocrotaline] CTD PMID:21224054 NCBI chr11:89,293,547...89,510,948
Ensembl chr11:89,293,696...89,510,871
JBrowse link
G Prl prolactin decreases expression EXP Phenytoin results in decreased expression of PRL mRNA; Phenytoin results in decreased expression of PRL protein CTD PMID:3734668 NCBI chr17:39,814,236...39,824,299
Ensembl chr17:39,814,244...39,824,299
JBrowse link
G Prmt3 protein arginine methyltransferase 3 increases expression EXP Phenytoin results in increased expression of PRMT3 mRNA CTD PMID:20345932 NCBI chr 1:105,113,595...105,200,253
Ensembl chr 1:105,113,595...105,200,470
JBrowse link
G Prss12 serine protease 12 increases expression ISO Phenytoin results in increased expression of PRSS12 mRNA CTD PMID:14741686 NCBI chr 2:227,657,983...227,717,884
Ensembl chr 2:227,657,983...227,717,884
JBrowse link
G Psip1 PC4 and SFRS1 interacting protein 1 increases expression EXP Phenytoin results in increased expression of PSIP1 mRNA CTD PMID:20345932 NCBI chr 5:101,555,691...101,588,659
Ensembl chr 5:101,555,694...101,588,598
JBrowse link
G Psmc6 proteasome 26S subunit, ATPase 6 increases expression EXP Phenytoin results in increased expression of PSMC6 mRNA CTD PMID:20345932 NCBI chr15:19,667,453...19,688,916
Ensembl chr15:19,667,453...19,688,914
JBrowse link
G Psmd12 proteasome 26S subunit, non-ATPase 12 increases expression EXP Phenytoin results in increased expression of PSMD12 mRNA CTD PMID:20345932 NCBI chr10:95,706,808...95,725,452
Ensembl chr10:95,706,685...95,725,812
JBrowse link
G Ptbp2 polypyrimidine tract binding protein 2 increases expression EXP Phenytoin results in increased expression of PTBP2 mRNA CTD PMID:20345932 NCBI chr 2:223,261,444...223,323,075
Ensembl chr 2:223,262,852...223,322,585
JBrowse link
G Ptch1 patched 1 increases expression ISO Phenytoin results in increased expression of PTCH1 mRNA CTD PMID:16141649 NCBI chr17:1,032,242...1,085,885
Ensembl chr17:1,029,048...1,093,873
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression EXP Phenytoin results in increased expression of PTGS2 mRNA CTD PMID:20345932 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Pth parathyroid hormone increases expression ISO Phenytoin results in increased expression of PTH protein CTD PMID:20683115 NCBI chr 1:178,215,829...178,218,761
Ensembl chr 1:178,215,829...178,218,761
JBrowse link
G Rad50 RAD50 double strand break repair protein multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of RAD50 mRNA CTD PMID:21224054 NCBI chr10:39,002,130...39,054,042
Ensembl chr10:39,001,498...39,054,142
JBrowse link
G Rai1 retinoic acid induced 1 increases expression EXP Phenytoin results in increased expression of RAI1 mRNA CTD PMID:20345932 NCBI chr10:46,511,271...46,571,591
Ensembl chr10:46,511,271...46,571,583
JBrowse link
G Ranbp6 RAN binding protein 6 increases expression EXP Phenytoin results in increased expression of RANBP6 mRNA CTD PMID:20345932 NCBI chr 1:247,980,976...247,985,553
Ensembl chr 1:247,982,180...247,985,497
JBrowse link
G Rapgef4 Rap guanine nucleotide exchange factor 4 increases expression EXP Phenytoin results in increased expression of RAPGEF4 mRNA CTD PMID:20345932 NCBI chr 3:58,632,338...58,925,127
Ensembl chr 3:58,632,476...58,924,038
JBrowse link
G Rara retinoic acid receptor, alpha increases expression
decreases expression
ISO Phenytoin results in increased expression of RARA mRNA
Phenytoin results in decreased expression of RARA mRNA
CTD PMID:9118846 PMID:9988880 NCBI chr10:86,838,819...86,884,224
Ensembl chr10:86,860,685...86,884,210
JBrowse link
G Rarb retinoic acid receptor, beta increases expression ISO Phenytoin results in increased expression of RARB mRNA CTD PMID:9988880 NCBI chr15:9,915,223...10,262,599
Ensembl chr15:10,120,206...10,262,599
JBrowse link
G Rarg retinoic acid receptor, gamma increases expression ISO Phenytoin results in increased expression of RARG mRNA CTD PMID:9988880 NCBI chr 7:143,840,739...143,863,206
Ensembl chr 7:143,839,980...143,863,186
JBrowse link
G Rbm12 RNA binding motif protein 12 increases expression EXP Phenytoin results in increased expression of RBM12 mRNA CTD PMID:20345932 NCBI chr 3:151,616,038...151,658,427
Ensembl chr 3:151,641,095...151,658,417
Ensembl chr 3:151,641,095...151,658,417
Ensembl chr 3:151,641,095...151,658,417
Ensembl chr 3:151,641,095...151,658,417
JBrowse link
G Rbm3 RNA binding motif protein 3 increases expression EXP Phenytoin results in increased expression of RBM3 mRNA CTD PMID:20345932 NCBI chr  X:15,098,880...15,102,344
Ensembl chr  X:15,098,904...15,102,340
JBrowse link
G Rbm34 RNA binding motif protein 34 increases expression EXP Phenytoin results in increased expression of RBM34 mRNA CTD PMID:20345932 NCBI chr19:59,874,745...59,894,981
Ensembl chr19:59,874,752...59,894,937
JBrowse link
G Rbp2 retinol binding protein 2 increases expression ISO Phenytoin results in increased expression of RBP2 mRNA CTD PMID:9118846 NCBI chr 8:106,479,253...106,527,726
Ensembl chr 8:106,503,504...106,527,711
JBrowse link
G Rdh14 retinol dehydrogenase 14 increases expression EXP Phenytoin results in increased expression of RDH14 mRNA CTD PMID:20345932 NCBI chr 6:36,106,926...36,112,069
Ensembl chr 6:36,107,147...36,112,064
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
increases activity
ISO Phenytoin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased localization of and results in increased activity of RELA protein]
Phenytoin results in increased activity of RELA protein
CTD PMID:10700573 PMID:15322231 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Rhoa ras homolog family member A decreases expression ISO Phenytoin results in decreased expression of RHOA mRNA CTD PMID:15136057 NCBI chr 8:117,082,440...117,116,244
Ensembl chr 8:117,106,576...117,116,167
JBrowse link
G Riok2 RIO kinase 2 increases expression EXP Phenytoin results in increased expression of RIOK2 mRNA CTD PMID:20345932 NCBI chr 1:59,130,008...59,146,457
Ensembl chr 1:59,129,951...59,146,776
JBrowse link
G Rnaseh1 ribonuclease H1 decreases expression EXP Phenytoin results in decreased expression of RNASEH1 mRNA CTD PMID:20345932 NCBI chr 6:47,916,188...47,925,582
Ensembl chr 6:47,916,188...47,925,571
JBrowse link
G Rnd1 Rho family GTPase 1 increases expression EXP Phenytoin results in increased expression of RND1 mRNA CTD PMID:20345932 NCBI chr 7:140,349,138...140,356,209
Ensembl chr 7:140,349,138...140,356,209
JBrowse link
G Rnf115 ring finger protein 115 increases expression EXP Phenytoin results in increased expression of RNF115 mRNA CTD PMID:20345932 NCBI chr 2:198,852,392...198,920,000
Ensembl chr 2:198,852,500...198,919,995
JBrowse link
G Rpe ribulose-5-phosphate-3-epimerase increases expression EXP Phenytoin results in increased expression of RPE mRNA CTD PMID:20345932 NCBI chr 9:73,687,684...73,713,643
Ensembl chr 9:73,687,743...73,711,571
JBrowse link
G Rpl28 ribosomal protein L28 increases expression ISO Phenytoin results in increased expression of RPL28 mRNA CTD PMID:14741686 NCBI chr 1:72,619,282...72,621,941
Ensembl chr 1:72,619,282...72,621,519
JBrowse link
G Rps6ka3 ribosomal protein S6 kinase A3 increases expression EXP Phenytoin results in increased expression of RPS6KA3 mRNA CTD PMID:20345932 NCBI chr  X:37,469,736...37,576,055
Ensembl chr  X:37,469,937...37,575,624
JBrowse link
G Rpsa ribosomal protein SA increases expression ISO Phenytoin results in increased expression of RPSA mRNA CTD PMID:14741686 NCBI chr 8:128,806,053...128,809,987
Ensembl chr 8:128,806,129...128,809,986
JBrowse link
G Rsrc1 arginine and serine rich coiled-coil 1 decreases expression EXP Phenytoin results in decreased expression of RSRC1 mRNA CTD PMID:20345932 NCBI chr 2:164,126,898...164,533,652 JBrowse link
G Ryr2 ryanodine receptor 2 increases expression EXP Phenytoin results in increased expression of RYR2 mRNA CTD PMID:20345932 NCBI chr17:65,533,998...65,955,606
Ensembl chr17:65,535,403...65,955,606
JBrowse link
G S100a10 S100 calcium binding protein A10 increases expression ISO Phenytoin results in increased expression of S100A10 mRNA CTD PMID:14741686 NCBI chr 2:193,892,589...193,901,236
Ensembl chr 2:193,892,589...193,901,236
JBrowse link
G S100a4 S100 calcium-binding protein A4 increases expression ISO Phenytoin results in increased expression of S100A4 mRNA CTD PMID:14741686 NCBI chr 2:189,997,278...189,999,587
Ensembl chr 2:189,997,129...189,999,604
JBrowse link
G S100a8 S100 calcium binding protein A8 multiple interactions ISO [Phenytoin co-treated with Buthionine Sulfoximine] results in increased expression of S100A8 mRNA CTD PMID:23986454 NCBI chr 2:190,073,239...190,074,333
Ensembl chr 2:190,073,815...190,074,354
JBrowse link
G S100a9 S100 calcium binding protein A9 multiple interactions
increases expression
ISO [Phenytoin co-treated with Buthionine Sulfoximine] results in increased expression of S100A9 mRNA
Phenytoin results in increased expression of S100A9 mRNA
CTD PMID:23986454 NCBI chr 2:190,097,436...190,100,209
Ensembl chr 2:190,097,554...190,100,276
JBrowse link
G Sart3 spliceosome associated factor 3, U4/U6 recycling protein increases expression EXP Phenytoin results in increased expression of SART3 mRNA CTD PMID:20345932 NCBI chr12:48,628,198...48,656,096
Ensembl chr12:48,628,278...48,656,096
JBrowse link
G Sc5d sterol-C5-desaturase increases expression ISO Phenytoin results in increased expression of SC5D mRNA CTD PMID:14741686 NCBI chr 8:46,525,406...46,537,014
Ensembl chr 8:46,525,400...46,537,050
JBrowse link
G Scaf1 SR-related CTD-associated factor 1 increases expression EXP Phenytoin results in increased expression of SCAF1 mRNA CTD PMID:20345932 NCBI chr 1:100,997,724...101,010,855
Ensembl chr 1:100,997,745...101,008,266
JBrowse link
G Scarb1 scavenger receptor class B, member 1 decreases expression ISO Phenytoin results in decreased expression of SCARB1 mRNA CTD PMID:15136057 NCBI chr12:36,694,952...36,761,445
Ensembl chr12:36,694,960...36,761,455
JBrowse link
G Scn1a sodium voltage-gated channel alpha subunit 1 affects response to substance ISO SCN1A gene polymorphism affects the susceptibility to Phenytoin; SCN1A protein affects the susceptibility to Phenytoin CTD PMID:15805193 PMID:17001291 NCBI chr 3:52,388,811...52,533,365
Ensembl chr 3:52,381,975...52,510,507
JBrowse link
G Scn1b sodium voltage-gated channel beta subunit 1 affects binding
decreases response to substance
multiple interactions
ISO Phenytoin binds to [SCN1B protein binds to SCN3A protein]
SCN1B protein mutant form results in decreased susceptibility to Phenytoin
Phenytoin results in decreased activity of [SCN1B protein binds to SCN3A protein]
CTD PMID:15922564 NCBI chr 1:89,550,738...89,560,469
Ensembl chr 1:89,550,738...89,560,719
JBrowse link
G Scn2a sodium voltage-gated channel alpha subunit 2 decreases activity ISO Phenytoin results in decreased activity of SCN2A protein CTD PMID:11212204 NCBI chr 3:51,687,910...51,822,008
Ensembl chr 3:51,687,809...51,822,250
JBrowse link
G Scn3a sodium voltage-gated channel alpha subunit 3 multiple interactions
affects binding
ISO Phenytoin results in decreased activity of [SCN1B protein binds to SCN3A protein]
Phenytoin binds to [SCN1B protein binds to SCN3A protein]
CTD PMID:15922564 NCBI chr 3:51,530,897...51,643,140
Ensembl chr 3:51,532,627...51,643,140
JBrowse link
G Sdc4 syndecan 4 decreases expression ISO Phenytoin results in decreased expression of SDC4 mRNA CTD PMID:15136057 NCBI chr 3:160,872,503...160,891,190
Ensembl chr 3:160,872,503...160,891,190
JBrowse link
G Sele selectin E multiple interactions ISO [clobazam co-treated with Phenytoin] results in increased expression of SELE protein CTD PMID:16376047 NCBI chr13:82,355,234...82,365,323
Ensembl chr13:82,355,471...82,365,341
JBrowse link
G Senp7 SUMO specific peptidase 7 increases expression EXP Phenytoin results in increased expression of SENP7 mRNA CTD PMID:20345932 NCBI chr11:46,880,928...47,047,052
Ensembl chr11:46,880,928...47,027,667
JBrowse link
G Serpinc1 serpin family C member 1 multiple interactions ISO [clobazam co-treated with Phenytoin] results in increased expression of [F2 protein binds to SERPINC1 protein] CTD PMID:16376047 NCBI chr13:78,806,107...78,820,375
Ensembl chr13:78,805,347...78,833,192
JBrowse link
G Serpine1 serpin family E member 1 multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of SERPINE1 mRNA CTD PMID:21224054 NCBI chr12:22,641,104...22,651,482
Ensembl chr12:22,641,104...22,651,482
JBrowse link
G Sh3yl1 SH3 and SYLF domain containing 1 increases expression EXP Phenytoin results in increased expression of SH3YL1 mRNA CTD PMID:20345932 NCBI chr 6:49,851,778...49,895,502
Ensembl chr 6:49,852,130...49,895,510
JBrowse link
G Shh sonic hedgehog signaling molecule increases expression ISO Phenytoin results in increased expression of SHH mRNA CTD PMID:26272751 NCBI chr 4:718,538...727,691
Ensembl chr 4:718,538...727,691
JBrowse link
G Siah1 siah E3 ubiquitin protein ligase 1 increases expression EXP Phenytoin results in increased expression of SIAH1A mRNA CTD PMID:20345932 NCBI chr19:21,372,163...21,395,773
Ensembl chr19:21,372,163...21,395,767
JBrowse link
G Sipa1l1 signal-induced proliferation-associated 1 like 1 increases expression EXP Phenytoin results in increased expression of SIPA1L1 mRNA CTD PMID:20345932 NCBI chr 6:106,052,212...106,163,249
Ensembl chr 6:106,039,991...106,163,302
JBrowse link
G Slc22a7 solute carrier family 22 member 7 decreases expression EXP Phenytoin results in decreased expression of SLC22A7 mRNA CTD PMID:17381134 NCBI chr 9:16,925,321...16,931,119
Ensembl chr 9:16,924,520...16,931,766
JBrowse link
G Slc4a3 solute carrier family 4 member 3 increases expression EXP Phenytoin results in increased expression of SLC4A3 mRNA CTD PMID:20345932 NCBI chr 9:82,742,207...82,755,119
Ensembl chr 9:82,741,920...82,755,153
JBrowse link
G Smarca1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 increases expression EXP Phenytoin results in increased expression of SMARCA1 mRNA CTD PMID:20345932 NCBI chr  X:134,634,651...134,719,503
Ensembl chr  X:134,647,703...134,719,097
JBrowse link
G Smarca5 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 increases expression EXP Phenytoin results in increased expression of SMARCA5 mRNA CTD PMID:20345932 NCBI chr19:30,936,703...30,969,454
Ensembl chr19:30,936,703...30,969,454
JBrowse link
G Smc2 structural maintenance of chromosomes 2 increases expression EXP Phenytoin results in increased expression of SMC2 mRNA CTD PMID:20345932 NCBI chr 5:68,717,509...68,764,080
Ensembl chr 5:68,717,519...68,763,850
JBrowse link
G Smc3 structural maintenance of chromosomes 3 increases expression ISO Phenytoin results in increased expression of SMC3 mRNA CTD PMID:14741686 NCBI chr 1:274,310,120...274,352,856
Ensembl chr 1:274,309,758...274,352,854
JBrowse link
G Smc5 structural maintenance of chromosomes 5 increases expression EXP Phenytoin results in increased expression of SMC5 mRNA CTD PMID:20345932 NCBI chr 1:240,977,898...241,046,273
Ensembl chr 1:240,977,898...241,046,256
JBrowse link
G Snx2 sorting nexin 2 increases expression EXP Phenytoin results in increased expression of SNX2 mRNA CTD PMID:20345932 NCBI chr18:48,132,386...48,173,974
Ensembl chr18:48,132,414...48,173,971
JBrowse link
G Sp3 Sp3 transcription factor increases expression ISO Phenytoin results in increased expression of SP3 mRNA CTD PMID:14741686 NCBI chr 3:59,644,579...59,689,011
Ensembl chr 3:59,646,015...59,688,692
JBrowse link
G St13 ST13, Hsp70 interacting protein increases expression EXP Phenytoin results in increased expression of ST13 mRNA CTD PMID:17381134 NCBI chr 7:122,585,770...122,635,731
Ensembl chr 7:122,585,771...122,635,731
JBrowse link
G Stat4 signal transducer and activator of transcription 4 decreases expression ISO Phenytoin results in decreased expression of STAT4 mRNA CTD PMID:14741686 NCBI chr 9:54,340,649...54,457,753
Ensembl chr 9:54,287,541...54,484,533
JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 decreases expression EXP Phenytoin results in decreased expression of SULT1A1 mRNA CTD PMID:9566755 PMID:17381134 NCBI chr 1:198,100,586...198,104,106
Ensembl chr 1:198,100,586...198,104,109
JBrowse link
G Sult2a1 sulfotransferase family 2A member 1 decreases expression EXP Phenytoin results in decreased expression of SULT2A1 mRNA CTD PMID:9566755 NCBI chr 1:76,558,721...76,614,315
Ensembl chr 1:76,252,329...76,780,230
JBrowse link
G Syn1 synapsin I multiple interactions
decreases expression
ISO Thyroxine inhibits the reaction [Phenytoin results in decreased expression of SYN1 mRNA] CTD PMID:27413119 NCBI chr  X:1,321,315...1,379,202
Ensembl chr  X:1,321,315...1,379,198
JBrowse link
G Syp synaptophysin multiple interactions
decreases expression
ISO Thyroxine inhibits the reaction [Phenytoin results in decreased expression of SYP mRNA] CTD PMID:27413119 NCBI chr  X:15,694,699...15,709,244
Ensembl chr  X:15,695,566...15,707,436
JBrowse link
G Sypl1 synaptophysin-like 1 increases expression EXP Phenytoin results in increased expression of SYPL mRNA CTD PMID:20345932 NCBI chr 6:52,265,920...52,286,037
Ensembl chr 6:52,265,930...52,285,029
JBrowse link
G Taf9b TATA-box binding protein associated factor 9b increases expression EXP Phenytoin results in increased expression of TAF9B mRNA CTD PMID:20345932 NCBI chr  X:77,281,234...77,295,238
Ensembl chr  X:77,281,210...77,295,426
JBrowse link
G Tbx21 T-box transcription factor 21 multiple interactions
decreases expression
ISO [Phenytoin co-treated with Buthionine Sulfoximine] results in decreased expression of TBX21 mRNA
Phenytoin results in decreased expression of TBX21 mRNA
CTD PMID:23986454 NCBI chr10:85,032,799...85,049,331
Ensembl chr10:85,032,799...85,049,331
JBrowse link
G Tceal1 transcription elongation factor A like 1 increases expression EXP Phenytoin results in increased expression of TCEAL1 mRNA CTD PMID:20345932 NCBI chr  X:107,370,351...107,372,347
Ensembl chr  X:107,370,431...107,372,338
JBrowse link
G Tcf15 transcription factor 15 decreases expression ISO Phenytoin results in decreased expression of TCF15 mRNA CTD PMID:31711903 NCBI chr 3:147,643,250...147,649,511
Ensembl chr 3:147,643,250...147,649,504
JBrowse link
G Terf1 telomeric repeat binding factor 1 increases expression EXP Phenytoin results in increased expression of TERF1 mRNA CTD PMID:20345932 NCBI chr 5:2,853,455...2,882,731
Ensembl chr 5:2,853,459...2,882,668
JBrowse link
G Tgfa transforming growth factor alpha increases expression ISO Phenytoin results in increased expression of TGFA mRNA CTD PMID:9988880 NCBI chr 4:117,961,877...118,045,923
Ensembl chr 4:117,962,319...118,046,344
JBrowse link
G Tgfb1 transforming growth factor, beta 1 increases expression
decreases expression
ISO Phenytoin results in increased expression of TGFB1 mRNA
Phenytoin results in decreased expression of TGFB1 mRNA
CTD PMID:7841657 PMID:9988880 PMID:16141649 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Tgfb2 transforming growth factor, beta 2 decreases expression ISO Phenytoin results in decreased expression of TGFB2 mRNA CTD PMID:9118846 NCBI chr13:105,039,639...105,142,010
Ensembl chr13:105,039,853...105,141,030
JBrowse link
G Tgfb3 transforming growth factor, beta 3 increases expression ISO Phenytoin results in increased expression of TGFB3 mRNA CTD PMID:14741686 NCBI chr 6:109,913,757...109,936,217
Ensembl chr 6:109,913,757...109,935,533
JBrowse link
G Thoc6 THO complex 6 decreases expression EXP Phenytoin results in decreased expression of THOC6 mRNA CTD PMID:20345932 NCBI chr10:12,989,135...12,994,495
Ensembl chr10:12,989,135...12,994,495
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 increases expression ISO Phenytoin results in increased expression of TIMP1 mRNA; Phenytoin results in increased expression of TIMP1 protein CTD PMID:10914799 PMID:14741686 PMID:15948689 NCBI chr  X:1,364,771...1,369,451
Ensembl chr  X:1,364,786...1,369,384
JBrowse link
G Tkt transketolase increases expression EXP Phenytoin results in increased expression of TKT mRNA CTD PMID:17381134 NCBI chr16:6,609,670...6,634,608
Ensembl chr16:6,609,668...6,634,595
JBrowse link
G Tlr2 toll-like receptor 2 multiple interactions
increases expression
ISO [Phenytoin co-treated with Buthionine Sulfoximine] results in increased expression of TLR2 mRNA
Phenytoin results in increased expression of TLR2 mRNA
CTD PMID:23986454 NCBI chr 2:182,840,171...182,846,061
Ensembl chr 2:182,840,727...182,846,061
JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions
decreases expression
ISO [Phenytoin co-treated with Buthionine Sulfoximine] results in decreased expression of TLR4 mRNA
Phenytoin results in decreased expression of TLR4 mRNA
CTD PMID:23986454 NCBI chr 5:82,587,424...82,601,056
Ensembl chr 5:82,587,420...82,601,052
JBrowse link
G Tlr9 toll-like receptor 9 multiple interactions
decreases expression
ISO [Phenytoin co-treated with Buthionine Sulfoximine] results in decreased expression of TLR9 mRNA
Phenytoin results in decreased expression of TLR9 mRNA
CTD PMID:23986454 NCBI chr 8:114,916,122...114,920,171
Ensembl chr 8:114,916,122...114,920,171
JBrowse link
G Tnf tumor necrosis factor increases expression ISO Phenytoin results in increased expression of TNF mRNA CTD PMID:14741686 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tnfsf10 TNF superfamily member 10 multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of TNFSF10 mRNA CTD PMID:21224054 NCBI chr 2:113,008,008...113,026,899
Ensembl chr 2:113,007,549...113,026,899
JBrowse link
G Tp53 tumor protein p53 increases expression ISO Phenytoin results in increased expression of TP53 mRNA CTD PMID:11134551 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Tp53bp2 tumor protein p53 binding protein, 2 increases expression EXP Phenytoin results in increased expression of TRP53BP2 mRNA CTD PMID:20345932 NCBI chr13:100,817,206...100,873,837
Ensembl chr13:100,817,359...100,873,890
JBrowse link
G Tradd TNFRSF1A-associated via death domain multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of TRADD mRNA CTD PMID:21224054 NCBI chr19:37,214,461...37,221,099
Ensembl chr19:37,214,471...37,216,572
JBrowse link
G Trmt10b tRNA methyltransferase 10B increases expression EXP Phenytoin results in increased expression of TRMT10B mRNA CTD PMID:20345932 NCBI chr 5:60,841,517...60,866,480
Ensembl chr 5:60,850,852...60,865,207
JBrowse link
G Tut4 terminal uridylyl transferase 4 increases expression EXP Phenytoin results in increased expression of TUT4 mRNA CTD PMID:20345932 NCBI chr 5:128,063,880...128,168,726
Ensembl chr 5:128,083,118...128,168,207
JBrowse link
G Txnrd1 thioredoxin reductase 1 increases expression EXP Phenytoin results in increased expression of TXNRD1 mRNA CTD PMID:17381134 NCBI chr 7:26,946,124...26,984,400
Ensembl chr 7:26,946,125...26,984,400
JBrowse link
G Ube2d2 ubiquitin-conjugating enzyme E2D 2 increases expression EXP Phenytoin results in increased expression of UBE2D2 mRNA CTD PMID:20345932 NCBI chr18:28,561,957...28,603,335
Ensembl chr18:28,594,892...28,603,335
JBrowse link
G Ubl5 ubiquitin-like 5 decreases expression EXP Phenytoin results in decreased expression of UBL5 mRNA CTD PMID:20345932 NCBI chr 8:21,663,257...21,665,049
Ensembl chr 8:21,663,325...21,665,038
JBrowse link
G Ubr1 ubiquitin protein ligase E3 component n-recognin 1 increases expression EXP Phenytoin results in increased expression of UBR1 mRNA CTD PMID:20345932 NCBI chr 3:112,800,557...112,910,038
Ensembl chr 3:112,800,557...112,876,773
JBrowse link
G Ugdh UDP-glucose 6-dehydrogenase decreases expression EXP Phenytoin results in decreased expression of UGDH mRNA CTD PMID:17381134 NCBI chr14:44,479,614...44,502,845
Ensembl chr14:44,479,614...44,502,845
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 affects expression
increases activity
multiple interactions
increases expression
ISO
EXP
Phenytoin affects the expression of UGT1A1 mRNA
Phenytoin results in increased activity of UGT1A1 protein
Phenytoin results in increased expression of and results in increased activity of UGT1A1 protein
Phenytoin results in increased expression of UGT1A1 mRNA
Phenytoin results in increased expression of UGT1A1 mRNA; Phenytoin results in increased expression of UGT1A1 protein
CTD PMID:10421657 PMID:15849716 PMID:17381134 PMID:27413119 NCBI chr 9:95,295,701...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 increases expression EXP Phenytoin results in increased expression of UGT1A6 mRNA CTD PMID:17381134 NCBI chr 9:95,241,609...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt2b17 UDP glucuronosyltransferase family 2 member B17 increases expression EXP Phenytoin results in increased expression of UGT2B1 mRNA CTD PMID:17381134 NCBI chr14:22,724,399...22,736,148
Ensembl chr14:22,724,070...22,825,444
JBrowse link
G Uncx UNC homeobox decreases expression ISO Phenytoin results in decreased expression of UNCX mRNA CTD PMID:31711903 NCBI chr12:17,182,158...17,186,679
Ensembl chr12:17,182,163...17,186,679
JBrowse link
G Ung uracil-DNA glycosylase multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of UNG mRNA CTD PMID:21224054 NCBI chr12:48,246,593...48,255,547
Ensembl chr12:48,246,569...48,254,822
JBrowse link
G Vars2 valyl-tRNA synthetase 2, mitochondrial increases expression EXP Phenytoin results in increased expression of VARS2 mRNA CTD PMID:20345932 NCBI chr20:3,588,462...3,599,514
Ensembl chr20:3,588,497...3,599,514
JBrowse link
G Vcan versican increases expression ISO Phenytoin results in increased expression of VCAN mRNA CTD PMID:14741686 NCBI chr 2:18,490,102...18,587,340
Ensembl chr 2:18,490,102...18,565,842
JBrowse link
G Vegfb vascular endothelial growth factor B decreases expression ISO Phenytoin results in decreased expression of VEGFB mRNA CTD PMID:14741686 NCBI chr 1:222,237,000...222,242,786
Ensembl chr 1:222,239,022...222,242,644
JBrowse link
G Vim vimentin increases expression ISO Phenytoin results in increased expression of VIM mRNA CTD PMID:14741686 NCBI chr17:80,882,715...80,891,200
Ensembl chr17:80,882,666...80,891,212
JBrowse link
G Wnt1 Wnt family member 1 decreases expression ISO Phenytoin results in decreased expression of WNT1 mRNA CTD PMID:7841657 NCBI chr 7:140,464,999...140,469,046
Ensembl chr 7:140,464,999...140,469,046
JBrowse link
G Wnt3 Wnt family member 3 decreases expression ISO Phenytoin results in decreased expression of WNT3 mRNA CTD PMID:26272751 NCBI chr10:91,830,709...91,874,907
Ensembl chr10:91,830,654...91,874,793
JBrowse link
G Wnt5a Wnt family member 5A increases expression ISO Phenytoin results in increased expression of WNT5A mRNA CTD PMID:31711903 NCBI chr16:4,469,451...4,490,271
Ensembl chr16:4,469,468...4,489,860
JBrowse link
G Xrcc4 X-ray repair cross complementing 4 multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of XRCC4 mRNA CTD PMID:21224054 NCBI chr 2:18,674,496...18,927,463
Ensembl chr 2:18,677,220...18,927,365
JBrowse link
G Yme1l1 YME1-like 1 ATPase increases expression EXP Phenytoin results in increased expression of YME1L1 mRNA CTD PMID:20345932 NCBI chr17:89,701,899...89,741,919
Ensembl chr17:89,704,102...89,741,321
JBrowse link
G Zap70 zeta chain of T cell receptor associated protein kinase 70 decreases expression ISO Phenytoin results in decreased expression of ZAP70 mRNA CTD PMID:15136057 NCBI chr 9:43,331,149...43,353,097
Ensembl chr 9:43,331,155...43,353,113
JBrowse link
G Zfp131 zinc finger protein 131 increases expression EXP Phenytoin results in increased expression of ZFP131 mRNA CTD PMID:20345932 NCBI chr 2:52,503,185...52,532,097
Ensembl chr 2:52,504,315...52,531,085
JBrowse link
G Zfp503 zinc finger protein 503 increases expression EXP Phenytoin results in increased expression of ZFP503 mRNA CTD PMID:20345932 NCBI chr15:2,374,582...2,378,370
Ensembl chr15:2,374,582...2,378,370
JBrowse link
G Zfp638 zinc finger protein 638 increases expression EXP Phenytoin results in increased expression of ZFP638 mRNA CTD PMID:20345932 NCBI chr 4:115,555,185...115,690,272
Ensembl chr 4:115,601,661...115,690,272
JBrowse link
G Zscan21 zinc finger and SCAN domain containing 21 increases expression EXP Phenytoin results in increased expression of ZSCAN21 mRNA CTD PMID:20345932 NCBI chr12:19,262,977...19,277,913
Ensembl chr12:19,262,977...19,277,910
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19810
    chemical entity 19810
      atom 19808
        nonmetal atom 19683
          nitrogen atom 18565
            nitrogen molecular entity 18565
              organonitrogen compound 18335
                organonitrogen heterocyclic compound 17481
                  diazolidine 587
                    imidazolidines 577
                      imidazolidinone 478
                        imidazolidine-2,4-dione 457
                          (5R)-5-methylimidazolidine-2,4-dione 0
                          (5S)-5-methylimidazolidine-2,4-dione 0
                          (5S,5aR,8aS,8bR)-7-tert-butyl-5-(4-methoxyphenyl)-8b-methyl-2-(3-methylphenyl)-5a,8a-dihydro-5H-pyrrolo[1,2]pyrrolo[4,5-a]imidazole-1,3,6,8-tetrone 0
                          1-(hydroxymethyl)-5,5-dimethylhydantoin 0
                          1-[(5-nitro-2-furanyl)methylideneamino]imidazolidine-2,4-dione 0
                          2-(2',5'-dioxo-1'-spiro[3,4-dihydro-2H-1-benzopyran-4,4'-imidazolidine]yl)-N-[4-[ethyl(propan-2-yl)amino]phenyl]acetamide 0
                          2-(2,5-dioxo-4,4-dipropyl-1-imidazolidinyl)-N-(3-methoxyphenyl)acetamide 0
                          2-(2,5-dioxo-4-imidazolidinyl)-N-(1-naphthalenyl)acetamide 0
                          2-(4-butyl-4-methyl-2,5-dioxo-1-imidazolidinyl)-N-[4-(4-morpholinylsulfonyl)phenyl]acetamide 0
                          2-[4-(2-furanylmethylidene)-2,5-dioxo-1-imidazolidinyl]-N-(4-methylphenyl)acetamide 0
                          2-[4-(4-methoxyphenyl)-4-methyl-2,5-dioxo-1-imidazolidinyl]-N-[4-(6-methyl-1,3-benzothiazol-2-yl)phenyl]acetamide 0
                          2-[4-[(1-ethyl-2,5-dimethyl-3-pyrrolyl)methylidene]-2,5-dioxo-1-imidazolidinyl]-N-(3-methylphenyl)acetamide 0
                          2-[4-[(3-ethoxy-4-hydroxyphenyl)methylidene]-2,5-dioxo-1-imidazolidinyl]-N-(3-methylphenyl)acetamide 0
                          2-[4-[4-(difluoromethoxy)phenyl]-4-methyl-2,5-dioxo-1-imidazolidinyl]acetic acid ethyl ester 0
                          2-[[2-(4-ethyl-4-methyl-2,5-dioxo-1-imidazolidinyl)-1-oxoethyl]amino]-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxamide 0
                          3,6,8-Trimethylallantoin 0
                          3-(\{(5R)-3-[3-(1H-imidazol-1-yl)propyl]-5-methyl-5-naphthalen-1-yl-2,4-dioxoimidazolidin-1-yl\}methyl)benzonitrile 0
                          3-[(2-fluorophenyl)methyl]-5-(1H-indol-3-ylmethylidene)imidazolidine-2,4-dione 0
                          3-[(2-fluorophenyl)methyl]-5-[(5-methyl-2-furanyl)methylidene]imidazolidine-2,4-dione 0
                          3-[(4S)-2,5-dioxoimidazolidin-4-yl]propanoic acid 0
                          3-[2-[4-(4-chlorophenyl)sulfonyl-1-piperazinyl]-2-oxoethyl]-5-(2-methylpropyl)imidazolidine-2,4-dione 0
                          3-[2-[[1-(3-chlorophenyl)-2,5-dioxo-4-imidazolidinylidene]methyl]-1-pyrrolyl]benzoic acid 0
                          3-[2-hydroxy-3-(4-morpholinyl)propyl]-5,5-dimethylimidazolidine-2,4-dione 0
                          4-[(2,4-dioxo-1,3-diazaspiro[4.5]decan-3-yl)methyl]benzoic acid methyl ester 0
                          4-[2-[(2,5-dioxo-1-phenyl-4-imidazolidinylidene)methyl]-1-pyrrolyl]benzoic acid 0
                          4-[5-[[1-[(2-chlorophenyl)methyl]-2,5-dioxo-4-imidazolidinylidene]methyl]-2-furanyl]-3-methylbenzoic acid 0
                          4-[[2-ethoxy-4-[(1-ethyl-2,5-dioxo-4-imidazolidinylidene)methyl]-6-prop-2-enylphenoxy]methyl]benzoic acid 0
                          4-hydroxyphenytoin 4
                          5-(2-furanylmethylidene)imidazolidine-2,4-dione 0
                          5-(4-hydroxybutyl)hydantoin 0
                          5-[(1-ethyl-2,5-dimethyl-3-pyrrolyl)methylidene]-3-phenylimidazolidine-2,4-dione 0
                          5-[(2,4,5-trihydroxyphenyl)methyl]imidazolidine-2,4-dione 0
                          5-[[2,5-dimethyl-1-(3-pyridinyl)-3-pyrrolyl]methylidene]-3-phenylimidazolidine-2,4-dione 0
                          5-guanidinohydantoin 0
                          5-methyl-3-[2-(4-morpholinyl)-2-oxoethyl]-5-phenylimidazolidine-2,4-dione 0
                          5-methylimidazolidine-2,4-dione 0
                          7-[3-(3-cyclohexyl-3-hydroxypropyl)-2,5-dioxoimidazolidin-4-yl]heptanoic acid + 2
                          Azimilide 1
                          D-5-monosubstituted hydantoin + 0
                          Fosphenytoin 0
                          Idanpramine 0
                          L-5-carboxymethylhydantoin 0
                          L-5-monosubstituted hydantoin + 0
                          N-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-[4-methyl-2,5-dioxo-4-(2-phenylethyl)-1-imidazolidinyl]acetamide 0
                          N-(3-cyanophenyl)-2-(4-ethyl-2,5-dioxo-4-phenyl-1-imidazolidinyl)acetamide 0
                          N-(3-methylphenyl)-2-[4-[(5-methyl-2-thiophenyl)methylidene]-2,5-dioxo-1-imidazolidinyl]acetamide 0
                          N-(4-ethoxyphenyl)-2-[4-[2-(methylthio)ethyl]-2,5-dioxo-1-imidazolidinyl]acetamide 0
                          N-(4-methylphenyl)-2-[4-[(5-methyl-2-thiophenyl)methylidene]-2,5-dioxo-1-imidazolidinyl]acetamide 0
                          N-[3-(1-azepanylsulfonyl)phenyl]-2-[4-(1H-indol-3-ylmethyl)-2,5-dioxo-1-imidazolidinyl]acetamide 0
                          N-[4-(6-methyl-1,3-benzothiazol-2-yl)phenyl]-2-[4-methyl-4-(4-methylphenyl)-2,5-dioxo-1-imidazolidinyl]acetamide 0
                          N-methylhydantoin 0
                          Nirvanol 0
                          RO4927350 0
                          allantoin + 3
                          amino(diphenylhydantoin) valeric acid 0
                          azumolene 0
                          clodantoin 0
                          dantrolene 41
                          diazolidinylurea 0
                          ethotoin + 1
                          furagin 0
                          hydantoin + 411
                          hydantoin-5-propionic acid 0
                          iprodione 18
                          mephenytoin 8
                          nifurfoline 0
                          nifurtoinol 0
                          nitrofurantoin 21
                          phenytoin 406
                          phethenylate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19810
    subatomic particle 19808
      composite particle 19808
        hadron 19808
          baryon 19808
            nucleon 19808
              atomic nucleus 19808
                atom 19808
                  main group element atom 19696
                    p-block element atom 19696
                      carbon group element atom 19599
                        carbon atom 19588
                          organic molecular entity 19588
                            organic molecule 19514
                              organic cyclic compound 19311
                                organic heterocyclic compound 18425
                                  organic heteromonocyclic compound 16467
                                    diazolidine 587
                                      imidazolidines 577
                                        imidazolidinone 478
                                          imidazolidine-2,4-dione 457
                                            (5R)-5-methylimidazolidine-2,4-dione 0
                                            (5S)-5-methylimidazolidine-2,4-dione 0
                                            (5S,5aR,8aS,8bR)-7-tert-butyl-5-(4-methoxyphenyl)-8b-methyl-2-(3-methylphenyl)-5a,8a-dihydro-5H-pyrrolo[1,2]pyrrolo[4,5-a]imidazole-1,3,6,8-tetrone 0
                                            1-(hydroxymethyl)-5,5-dimethylhydantoin 0
                                            1-[(5-nitro-2-furanyl)methylideneamino]imidazolidine-2,4-dione 0
                                            2-(2',5'-dioxo-1'-spiro[3,4-dihydro-2H-1-benzopyran-4,4'-imidazolidine]yl)-N-[4-[ethyl(propan-2-yl)amino]phenyl]acetamide 0
                                            2-(2,5-dioxo-4,4-dipropyl-1-imidazolidinyl)-N-(3-methoxyphenyl)acetamide 0
                                            2-(2,5-dioxo-4-imidazolidinyl)-N-(1-naphthalenyl)acetamide 0
                                            2-(4-butyl-4-methyl-2,5-dioxo-1-imidazolidinyl)-N-[4-(4-morpholinylsulfonyl)phenyl]acetamide 0
                                            2-[4-(2-furanylmethylidene)-2,5-dioxo-1-imidazolidinyl]-N-(4-methylphenyl)acetamide 0
                                            2-[4-(4-methoxyphenyl)-4-methyl-2,5-dioxo-1-imidazolidinyl]-N-[4-(6-methyl-1,3-benzothiazol-2-yl)phenyl]acetamide 0
                                            2-[4-[(1-ethyl-2,5-dimethyl-3-pyrrolyl)methylidene]-2,5-dioxo-1-imidazolidinyl]-N-(3-methylphenyl)acetamide 0
                                            2-[4-[(3-ethoxy-4-hydroxyphenyl)methylidene]-2,5-dioxo-1-imidazolidinyl]-N-(3-methylphenyl)acetamide 0
                                            2-[4-[4-(difluoromethoxy)phenyl]-4-methyl-2,5-dioxo-1-imidazolidinyl]acetic acid ethyl ester 0
                                            2-[[2-(4-ethyl-4-methyl-2,5-dioxo-1-imidazolidinyl)-1-oxoethyl]amino]-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxamide 0
                                            3,6,8-Trimethylallantoin 0
                                            3-(\{(5R)-3-[3-(1H-imidazol-1-yl)propyl]-5-methyl-5-naphthalen-1-yl-2,4-dioxoimidazolidin-1-yl\}methyl)benzonitrile 0
                                            3-[(2-fluorophenyl)methyl]-5-(1H-indol-3-ylmethylidene)imidazolidine-2,4-dione 0
                                            3-[(2-fluorophenyl)methyl]-5-[(5-methyl-2-furanyl)methylidene]imidazolidine-2,4-dione 0
                                            3-[(4S)-2,5-dioxoimidazolidin-4-yl]propanoic acid 0
                                            3-[2-[4-(4-chlorophenyl)sulfonyl-1-piperazinyl]-2-oxoethyl]-5-(2-methylpropyl)imidazolidine-2,4-dione 0
                                            3-[2-[[1-(3-chlorophenyl)-2,5-dioxo-4-imidazolidinylidene]methyl]-1-pyrrolyl]benzoic acid 0
                                            3-[2-hydroxy-3-(4-morpholinyl)propyl]-5,5-dimethylimidazolidine-2,4-dione 0
                                            4-[(2,4-dioxo-1,3-diazaspiro[4.5]decan-3-yl)methyl]benzoic acid methyl ester 0
                                            4-[2-[(2,5-dioxo-1-phenyl-4-imidazolidinylidene)methyl]-1-pyrrolyl]benzoic acid 0
                                            4-[5-[[1-[(2-chlorophenyl)methyl]-2,5-dioxo-4-imidazolidinylidene]methyl]-2-furanyl]-3-methylbenzoic acid 0
                                            4-[[2-ethoxy-4-[(1-ethyl-2,5-dioxo-4-imidazolidinylidene)methyl]-6-prop-2-enylphenoxy]methyl]benzoic acid 0
                                            4-hydroxyphenytoin 4
                                            5-(2-furanylmethylidene)imidazolidine-2,4-dione 0
                                            5-(4-hydroxybutyl)hydantoin 0
                                            5-[(1-ethyl-2,5-dimethyl-3-pyrrolyl)methylidene]-3-phenylimidazolidine-2,4-dione 0
                                            5-[(2,4,5-trihydroxyphenyl)methyl]imidazolidine-2,4-dione 0
                                            5-[[2,5-dimethyl-1-(3-pyridinyl)-3-pyrrolyl]methylidene]-3-phenylimidazolidine-2,4-dione 0
                                            5-guanidinohydantoin 0
                                            5-methyl-3-[2-(4-morpholinyl)-2-oxoethyl]-5-phenylimidazolidine-2,4-dione 0
                                            5-methylimidazolidine-2,4-dione 0
                                            7-[3-(3-cyclohexyl-3-hydroxypropyl)-2,5-dioxoimidazolidin-4-yl]heptanoic acid + 2
                                            Azimilide 1
                                            D-5-monosubstituted hydantoin + 0
                                            Fosphenytoin 0
                                            Idanpramine 0
                                            L-5-carboxymethylhydantoin 0
                                            L-5-monosubstituted hydantoin + 0
                                            N-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-[4-methyl-2,5-dioxo-4-(2-phenylethyl)-1-imidazolidinyl]acetamide 0
                                            N-(3-cyanophenyl)-2-(4-ethyl-2,5-dioxo-4-phenyl-1-imidazolidinyl)acetamide 0
                                            N-(3-methylphenyl)-2-[4-[(5-methyl-2-thiophenyl)methylidene]-2,5-dioxo-1-imidazolidinyl]acetamide 0
                                            N-(4-ethoxyphenyl)-2-[4-[2-(methylthio)ethyl]-2,5-dioxo-1-imidazolidinyl]acetamide 0
                                            N-(4-methylphenyl)-2-[4-[(5-methyl-2-thiophenyl)methylidene]-2,5-dioxo-1-imidazolidinyl]acetamide 0
                                            N-[3-(1-azepanylsulfonyl)phenyl]-2-[4-(1H-indol-3-ylmethyl)-2,5-dioxo-1-imidazolidinyl]acetamide 0
                                            N-[4-(6-methyl-1,3-benzothiazol-2-yl)phenyl]-2-[4-methyl-4-(4-methylphenyl)-2,5-dioxo-1-imidazolidinyl]acetamide 0
                                            N-methylhydantoin 0
                                            Nirvanol 0
                                            RO4927350 0
                                            allantoin + 3
                                            amino(diphenylhydantoin) valeric acid 0
                                            azumolene 0
                                            clodantoin 0
                                            dantrolene 41
                                            diazolidinylurea 0
                                            ethotoin + 1
                                            furagin 0
                                            hydantoin + 411
                                            hydantoin-5-propionic acid 0
                                            iprodione 18
                                            mephenytoin 8
                                            nifurfoline 0
                                            nifurtoinol 0
                                            nitrofurantoin 21
                                            phenytoin 406
                                            phethenylate 0
paths to the root