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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:imidazolidine-2,4-dione
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Accession:CHEBI:24628 term browser browse the term
Definition:An imidazolidinone with oxo groups at position 2 and 4.



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4-hydroxyphenytoin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 multiple interactions ISO [CYP2C9 protein results in increased hydroxylation of Phenytoin] which results in increased abundance of hydroxyphenytoin; Miconazole inhibits the reaction [[CYP2C9 protein results in increased hydroxylation of Phenytoin] which results in increased abundance of hydroxyphenytoin] CTD PMID:33961833 NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 multiple interactions ISO UGT1A1 protein results in increased glucuronidation of and results in decreased activity of hydroxyphenytoin CTD PMID:15855726 NCBI chr 9:88,801,344...88,808,465 JBrowse link
G Ugt1a5 UDP glucuronosyltransferase family 1 member A5 multiple interactions ISO UGT1A4 protein results in increased glucuronidation of and results in decreased activity of hydroxyphenytoin CTD PMID:15855726 NCBI chr 9:88,762,250...88,808,465 JBrowse link
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 multiple interactions ISO UGT1A6 protein results in increased glucuronidation of and results in decreased activity of hydroxyphenytoin CTD PMID:15855726 NCBI chr 9:88,747,229...88,808,465 JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 multiple interactions ISO UGT1A9 protein results in increased glucuronidation of and results in decreased activity of hydroxyphenytoin CTD PMID:15855726 NCBI chr 9:88,696,981...88,808,465 JBrowse link
7-[3-(3-cyclohexyl-3-hydroxypropyl)-2,5-dioxoimidazolidin-4-yl]heptanoic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ptgdr prostaglandin D2 receptor multiple interactions ISO
EXP
BW 245C binds to and results in increased activity of PTGDR protein; BW 245C inhibits the reaction [Prostaglandin D2 binds to PTGDR protein] CTD PMID:9579725 PMID:15528449 PMID:20719937 NCBI chr15:17,360,304...17,367,679 JBrowse link
G Tgfb1 transforming growth factor, beta 1 decreases response to substance ISO BW 245C results in decreased susceptibility to TGFB1 protein CTD PMID:20719937 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
allantoin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Col2a1 collagen type II alpha 1 chain multiple interactions EXP [COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Allantoin; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Allantoin]; huang-lien-chieh-tu-tang inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Allantoin] CTD PMID:24709313 NCBI chr 7:129,098,489...129,127,620
Ensembl chr 7:129,098,786...129,127,546
JBrowse link
G Il1b interleukin 1 beta increases secretion
decreases secretion
ISO
EXP
Allantoin results in increased secretion of IL1B protein
Allantoin results in decreased secretion of IL1B protein
CTD PMID:30654793 PMID:32382552 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 increases secretion
decreases secretion
ISO
EXP
Allantoin results in increased secretion of IL6 protein
Allantoin results in decreased secretion of IL6 protein
CTD PMID:30654793 PMID:32382552 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Lepr leptin receptor affects abundance ISO LEPR affects the abundance of Allantoin CTD PMID:20567778 NCBI chr 5:116,294,409...116,477,904
Ensembl chr 5:116,289,823...116,475,908
JBrowse link
G Nos2 nitric oxide synthase 2 decreases expression
increases expression
EXP
ISO
Allantoin results in decreased expression of NOS2 protein
Allantoin results in increased expression of NOS2 protein
CTD PMID:30654793 PMID:32382552 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases expression EXP Allantoin results in decreased expression of PTGS2 protein CTD PMID:30654793 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Tgfb1 transforming growth factor, beta 1 increases expression ISO Allantoin results in increased expression of TGFB1 protein CTD PMID:32382552 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Tnf tumor necrosis factor decreases secretion
increases secretion
EXP
ISO
Allantoin results in decreased secretion of TNF protein
Allantoin results in increased secretion of TNF protein
CTD PMID:30654793 PMID:32382552 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Vegfa vascular endothelial growth factor A increases expression
affects secretion
ISO
EXP
Allantoin results in increased expression of VEGFA protein
Allantoin affects the secretion of VEGFA protein
CTD PMID:30654793 PMID:32382552 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link
G Xdh xanthine dehydrogenase multiple interactions EXP [2,2,5,7,8-pentamethyl-1-hydroxychroman results in decreased activity of XDH protein] which results in decreased abundance of Allantoin CTD PMID:21920950 NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268
JBrowse link
Azimilide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity
multiple interactions
ISO azimilide results in decreased activity of KCNH2 protein
Acids inhibits the reaction [azimilide results in decreased activity of KCNH2 protein]; azimilide promotes the reaction [naringenin results in decreased activity of KCNH2 protein]; naringenin promotes the reaction [azimilide results in decreased activity of KCNH2 protein]; Potassium inhibits the reaction [azimilide results in decreased activity of KCNH2 protein]
CTD PMID:15821840 PMID:16960444 PMID:18057881 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
JBrowse link
dantrolene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcg2 ATP binding cassette subfamily G member 2 affects transport ISO ABCG2 protein affects the transport of Dantrolene CTD PMID:18322075 NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409
JBrowse link
G Ace2 angiotensin I converting enzyme 2 increases expression ISO Dantrolene results in increased expression of ACE2 mRNA CTD PMID:32808185 NCBI chr  X:30,293,597...30,340,961
Ensembl chr  X:30,293,589...30,340,977
JBrowse link
G Atf4 activating transcription factor 4 decreases expression
multiple interactions
EXP
ISO
Dantrolene results in decreased expression of ATF4 protein
Dantrolene affects the reaction [perfluorooctanoic acid results in increased expression of ATF4 protein]; Dantrolene inhibits the reaction [Thapsigargin results in increased expression of ATF4 protein]; Dantrolene promotes the reaction [Thapsigargin results in increased expression of ATF4 mRNA]
CTD PMID:15921666 PMID:32578922 NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO Dantrolene inhibits the reaction [Halothane results in increased expression of BAX mRNA] CTD PMID:32795494 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator increases expression EXP Dantrolene results in increased expression of BCL2 protein CTD PMID:10854250 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Bcl2l11 BCL2 like 11 multiple interactions ISO Dantrolene inhibits the reaction [Halothane results in increased expression of BCL2L11 mRNA] CTD PMID:32795494 NCBI chr 3:115,366,783...115,404,068
Ensembl chr 3:115,366,646...115,404,068
JBrowse link
G Bdnf brain-derived neurotrophic factor multiple interactions ISO Dantrolene inhibits the reaction [Oxygen deficiency results in increased secretion of BDNF protein] CTD PMID:16553631 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
JBrowse link
G Capn1 calpain 1 decreases expression EXP Dantrolene results in decreased expression of CAPN1 mRNA; Dantrolene results in decreased expression of CAPN1 protein CTD PMID:11236903 NCBI chr 1:203,275,912...203,300,848
Ensembl chr 1:203,277,344...203,300,177
JBrowse link
G Capn2 calpain 2 decreases expression EXP Dantrolene results in decreased expression of CAPN2 mRNA; Dantrolene results in decreased expression of CAPN2 protein CTD PMID:11236903 NCBI chr13:94,150,244...94,200,969
Ensembl chr13:94,150,240...94,200,969
JBrowse link
G Capn3 calpain 3 decreases expression EXP Dantrolene results in decreased expression of CAPN3 mRNA; Dantrolene results in decreased expression of CAPN3 protein CTD PMID:11236903 NCBI chr 3:107,407,518...107,457,858
Ensembl chr 3:107,407,850...107,457,858
JBrowse link
G Casp3 caspase 3 multiple interactions EXP
ISO
Dantrolene inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein]
Dantrolene inhibits the reaction [Indomethacin results in increased activity of CASP3 protein]
CTD PMID:17079870 PMID:23022152 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp9 caspase 9 multiple interactions ISO Dantrolene inhibits the reaction [Indomethacin results in increased activity of CASP9 protein] CTD PMID:23022152 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases expression EXP Dantrolene results in decreased expression of CCL2 mRNA CTD PMID:25051504 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 affects expression EXP Dantrolene affects the expression of CCL5 protein CTD PMID:25051504 NCBI chr10:68,322,826...68,327,365
Ensembl chr10:68,322,829...68,327,377
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 multiple interactions ISO Dantrolene inhibits the reaction [Halothane results in increased expression of CXCL2 mRNA] CTD PMID:32795494 NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO
EXP
Dantrolene inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein] CTD PMID:18493746 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions ISO Dantrolene inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A2 protein] CTD PMID:18493746 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 decreases phosphorylation
multiple interactions
EXP
ISO
Dantrolene results in decreased phosphorylation of DDIT3 protein
Dantrolene inhibits the reaction [Halothane results in increased expression of DDIT3 mRNA]; Dantrolene promotes the reaction [perfluorooctanoic acid results in increased expression of DDIT3 mRNA]; Dantrolene promotes the reaction [perfluorooctanoic acid results in increased expression of DDIT3 protein]
CTD PMID:15921666 PMID:32578922 PMID:32795494 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
JBrowse link
G Edn1 endothelin 1 decreases activity EXP Dantrolene results in decreased activity of EDN1 protein CTD PMID:12628492 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 decreases phosphorylation EXP Dantrolene results in decreased phosphorylation of EIF2AK3 protein CTD PMID:15921666 NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911
JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha decreases phosphorylation
multiple interactions
EXP
ISO
Dantrolene results in decreased phosphorylation of EIF2S1 protein
Dantrolene inhibits the reaction [tributyltin results in increased phosphorylation of EIF2S1 protein]
CTD PMID:15921666 PMID:23743301 NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225
JBrowse link
G Fkbp1a FKBP prolyl isomerase 1A multiple interactions ISO Dantrolene inhibits the reaction [Halothane results in increased expression of FKBP1A mRNA] CTD PMID:32795494 NCBI chr 3:140,040,359...140,060,107
Ensembl chr 3:140,040,278...140,060,743
JBrowse link
G Fkbp1b FKBP prolyl isomerase 1B multiple interactions ISO Dantrolene inhibits the reaction [Halothane results in increased expression of FKBP1B mRNA] CTD PMID:32795494 NCBI chr 6:27,832,128...27,850,600
Ensembl chr 6:27,838,802...27,848,653
JBrowse link
G Gfap glial fibrillary acidic protein multiple interactions EXP Dantrolene inhibits the reaction [diphenylditelluride results in decreased phosphorylation of GFAP protein]; Dantrolene inhibits the reaction [diphenylditelluride results in increased phosphorylation of GFAP protein] CTD PMID:21863293 PMID:21879721 NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO Dantrolene inhibits the reaction [Halothane results in increased expression of GPT protein] CTD PMID:32795494 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO Dantrolene inhibits the reaction [Halothane results in increased expression of HMOX1 mRNA] CTD PMID:32795494 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Homer1 homer scaffold protein 1 multiple interactions ISO Dantrolene inhibits the reaction [Halothane results in increased expression of HOMER1 mRNA] CTD PMID:32795494 NCBI chr 2:24,542,777...24,645,715
Ensembl chr 2:24,543,093...24,644,785
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions ISO Dantrolene inhibits the reaction [tributyltin results in increased expression of HSPA5 protein] CTD PMID:23743301 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
JBrowse link
G Ifng interferon gamma multiple interactions ISO Dantrolene inhibits the reaction [taurolithocholic acid 3-sulfate results in increased expression of IFNG mRNA] CTD PMID:22517774 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Igf1 insulin-like growth factor 1 decreases response to substance ISO Dantrolene results in decreased susceptibility to IGF1 protein CTD PMID:16485066 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296
JBrowse link
G Igf2 insulin-like growth factor 2 decreases response to substance ISO Dantrolene results in decreased susceptibility to IGF2 protein CTD PMID:16485066 NCBI chr 1:197,814,409...197,831,802
Ensembl chr 1:197,814,410...197,823,018
JBrowse link
G Il10 interleukin 10 multiple interactions
affects expression
ISO
EXP
Dantrolene inhibits the reaction [[chlorocresol results in increased activity of RYR1 protein] inhibits the reaction [Lipopolysaccharides results in increased expression of IL10 protein]]
Dantrolene affects the expression of IL10 protein
CTD PMID:17707769 PMID:25051504 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il1b interleukin 1 beta affects expression
multiple interactions
EXP
ISO
Dantrolene affects the expression of IL1B mRNA
Dantrolene inhibits the reaction [Halothane results in increased expression of IL1B mRNA]
CTD PMID:25051504 PMID:32795494 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 multiple interactions ISO Dantrolene inhibits the reaction [taurolithocholic acid 3-sulfate results in increased expression of IL6 mRNA] CTD PMID:22517774 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO Dantrolene results in decreased activity of KCNH2 protein CTD PMID:24052561 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
JBrowse link
G Kcnj11 potassium inwardly-rectifying channel, subfamily J, member 11 multiple interactions ISO Dantrolene inhibits the reaction [KCNJ11 protein mutant form results in increased abundance of Calcium] CTD PMID:17189350 NCBI chr 1:96,591,048...96,594,574
Ensembl chr 1:96,591,049...96,594,082
JBrowse link
G Lep leptin decreases expression EXP Dantrolene results in decreased expression of LEP protein CTD PMID:25051504 NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262
JBrowse link
G Mef2a myocyte enhancer factor 2a multiple interactions EXP Dantrolene inhibits the reaction [Caffeine results in increased expression of MEF2A mRNA]; Dantrolene inhibits the reaction [Caffeine results in increased expression of MEF2A protein] CTD PMID:25093688 NCBI chr 1:120,847,874...120,982,488
Ensembl chr 1:120,850,080...120,981,948
JBrowse link
G Mef2c myocyte enhancer factor 2C multiple interactions EXP Dantrolene inhibits the reaction [Caffeine results in increased expression of MEF2C mRNA]; Dantrolene inhibits the reaction [Caffeine results in increased expression of MEF2C protein] CTD PMID:25093688 NCBI chr 2:13,973,299...14,136,065
Ensembl chr 2:13,993,438...14,132,880
JBrowse link
G Myh7 myosin heavy chain 7 multiple interactions EXP Dantrolene inhibits the reaction [Caffeine results in increased expression of MYH7 mRNA] CTD PMID:25093688 NCBI chr15:28,446,550...28,469,888
Ensembl chr15:28,446,550...28,468,217
JBrowse link
G Nefl neurofilament light chain multiple interactions EXP Dantrolene inhibits the reaction [diphenylditelluride results in decreased phosphorylation of NEFL protein]; Dantrolene inhibits the reaction [diphenylditelluride results in increased phosphorylation of NEFL protein] CTD PMID:21863293 PMID:21879721 NCBI chr15:42,301,920...42,305,793
Ensembl chr15:42,301,916...42,305,793
JBrowse link
G Nefm neurofilament medium chain multiple interactions EXP Dantrolene inhibits the reaction [diphenylditelluride results in decreased phosphorylation of NEFM protein]; Dantrolene inhibits the reaction [diphenylditelluride results in increased phosphorylation of NEFM protein] CTD PMID:21863293 PMID:21879721 NCBI chr15:42,360,449...42,365,753
Ensembl chr15:42,360,454...42,365,755
JBrowse link
G Nppa natriuretic peptide A multiple interactions EXP Dantrolene inhibits the reaction [Caffeine results in increased expression of NPPA mRNA] CTD PMID:25093688 NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351
JBrowse link
G Nppb natriuretic peptide B multiple interactions EXP Dantrolene inhibits the reaction [Caffeine results in increased expression of NPPB mRNA] CTD PMID:25093688 NCBI chr 5:158,416,813...158,418,175
Ensembl chr 5:158,416,866...158,418,168
JBrowse link
G Ryr1 ryanodine receptor 1 multiple interactions ISO Dantrolene inhibits the reaction [[chlorocresol results in increased activity of RYR1 protein] inhibits the reaction [Lipopolysaccharides results in increased expression of IL10 protein]]; Dantrolene inhibits the reaction [[chlorocresol results in increased activity of RYR1 protein] which results in increased transport of Calcium] CTD PMID:17707769 NCBI chr 1:84,292,578...84,423,799
Ensembl chr 1:84,292,578...84,423,812
JBrowse link
G Ryr2 ryanodine receptor 2 multiple interactions EXP Dantrolene inhibits the reaction [Caffeine promotes the reaction [RYR2 protein results in increased secretion of Calcium]] CTD PMID:12887973 NCBI chr17:58,389,925...58,975,641
Ensembl chr17:58,389,925...58,975,142
JBrowse link
G S100a8 S100 calcium binding protein A8 multiple interactions ISO Dantrolene inhibits the reaction [Halothane results in increased expression of S100A8 mRNA] CTD PMID:32795494 NCBI chr 2:176,166,517...176,167,645
Ensembl chr 2:176,167,124...176,167,643
JBrowse link
G S100a9 S100 calcium binding protein A9 multiple interactions ISO Dantrolene inhibits the reaction [Halothane results in increased expression of S100A9 mRNA] CTD PMID:32795494 NCBI chr 2:176,190,361...176,193,182
Ensembl chr 2:176,190,361...176,193,230
JBrowse link
G Star steroidogenic acute regulatory protein multiple interactions ISO Dantrolene inhibits the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of STAR mRNA] CTD PMID:23183170 NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672
JBrowse link
G Tnf tumor necrosis factor decreases expression
multiple interactions
EXP
ISO
Dantrolene results in decreased expression of TNF protein
Dantrolene inhibits the reaction [Halothane results in increased expression of TNF mRNA]
CTD PMID:11236903 PMID:32795494 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO Dantrolene inhibits the reaction [Halothane results in increased expression of VCAM1 mRNA] CTD PMID:32795494 NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958
JBrowse link
G Vim vimentin multiple interactions EXP Dantrolene inhibits the reaction [diphenylditelluride results in decreased phosphorylation of VIM protein]; Dantrolene inhibits the reaction [diphenylditelluride results in increased phosphorylation of VIM protein] CTD PMID:21863293 PMID:21879721 NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187
JBrowse link
G Xbp1 X-box binding protein 1 multiple interactions ISO Dantrolene inhibits the reaction [perfluorooctanoic acid results in increased expression of XBP1 mRNA alternative form]; Dantrolene inhibits the reaction [Thapsigargin results in increased expression of XBP1 mRNA alternative form] CTD PMID:32578922 NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693
JBrowse link
ethotoin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO ethotoin binds to and results in increased activity of NR1I2 protein CTD PMID:15039302 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
JBrowse link
Hydroxymephenytoin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 increases chemical synthesis
multiple interactions
ISO CYP2C19 protein results in increased chemical synthesis of 4-hydroxymephenytoin
[CYP2C19 protein results in increased metabolism of Mephenytoin] which results in increased chemical synthesis of 4-hydroxymephenytoin; Fluoxetine inhibits the reaction [CYP2C19 protein results in increased chemical synthesis of 4-hydroxymephenytoin]; Omeprazole inhibits the reaction [CYP2C19 protein results in increased chemical synthesis of 4-hydroxymephenytoin]
CTD PMID:12401345 PMID:15155557 PMID:21915887 PMID:23850985 PMID:25084468 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
JBrowse link
iprodione term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor multiple interactions ISO
EXP
iprodione binds to and results in increased activity of AHR protein CTD PMID:14636698 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
JBrowse link
G Anxa10 annexin A10 increases expression ISO iprodione results in increased expression of ANXA10 mRNA CTD PMID:32194361 NCBI chr16:27,738,712...27,805,648
Ensembl chr16:27,738,712...27,805,648
JBrowse link
G Ar androgen receptor multiple interactions
affects binding
ISO [iprodione binds to and results in decreased activity of AR protein] inhibits the reaction [Metribolone binds to AR protein]; iprodione inhibits the reaction [[6-fluorotestosterone co-treated with Norgestrel] binds to and results in increased activity of AR protein]; iprodione inhibits the reaction [Dihydrotestosterone results in increased activity of AR protein]
iprodione binds to AR protein
CTD PMID:19564212 PMID:33049310 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions
EXP iprodione results in decreased expression of BCL2 protein
Chlorpyrifos promotes the reaction [iprodione results in decreased expression of BCL2 protein]; iprodione promotes the reaction [Chlorpyrifos results in decreased expression of BCL2 protein]
CTD PMID:33586219 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Casp3 caspase 3 increases expression
multiple interactions
EXP iprodione results in increased expression of CASP3 protein
Chlorpyrifos promotes the reaction [iprodione results in increased expression of CASP3 protein]
CTD PMID:33586219 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Cldn11 claudin 11 increases expression
multiple interactions
EXP iprodione results in increased expression of CLDN11 protein
[carbendazim co-treated with iprodione] results in decreased expression of CLDN11 protein
CTD PMID:28576679 NCBI chr 2:112,207,745...112,221,050
Ensembl chr 2:112,207,745...112,221,050
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 increases activity ISO iprodione results in increased activity of CYP19A1 protein CTD PMID:11884232 NCBI chr 8:54,553,165...54,580,758
Ensembl chr 8:54,553,165...54,580,758
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression ISO iprodione results in increased expression of CYP1A1 mRNA; iprodione results in increased expression of CYP1A1 protein CTD PMID:16696176 PMID:32194361 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 decreases expression ISO iprodione results in decreased expression of CYP2C19 protein CTD PMID:32194361 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions ISO [procymidone co-treated with iprodione co-treated with cyprodinil co-treated with fludioxonil co-treated with cyhalothrin] results in increased expression of CYP3A4 mRNA CTD PMID:25028461 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 decreases expression ISO iprodione results in decreased expression of CYP7A1 protein CTD PMID:32194361 NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO iprodione results in increased expression of DDIT3 mRNA CTD PMID:16696176 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO iprodione binds to and results in increased activity of ESR1 protein CTD PMID:33049310 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Esr2 estrogen receptor 2 multiple interactions ISO iprodione binds to and results in increased activity of ESR2 protein CTD PMID:33049310 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression ISO iprodione results in increased expression of FOS mRNA CTD PMID:16696176 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Fshb follicle stimulating hormone subunit beta multiple interactions EXP iprodione promotes the reaction [Chlorpyrifos results in decreased expression of FSHB protein] CTD PMID:33586219 NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370
JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha increases expression ISO iprodione results in increased expression of GADD45A mRNA CTD PMID:16696176 NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115
JBrowse link
G Gja1 gap junction protein, alpha 1 multiple interactions EXP [carbendazim co-treated with iprodione] results in decreased expression of GJA1 protein CTD PMID:28576679 NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582
JBrowse link
G Gsta2 glutathione S-transferase alpha 2 increases expression ISO iprodione results in increased expression of GSTA2 mRNA CTD PMID:16696176 NCBI chr 8:79,184,535...79,196,827
Ensembl chr 8:79,184,322...79,196,798
JBrowse link
G H2ax H2A.X variant histone multiple interactions ISO [fludioxonil co-treated with cyprodinil co-treated with procymidone co-treated with iprodione co-treated with cyhalothrin] results in increased phosphorylation of H2AX protein CTD PMID:22389207 NCBI chr 8:44,671,927...44,673,257
Ensembl chr 8:44,671,786...44,673,239
JBrowse link
G Hsd17b3 hydroxysteroid (17-beta) dehydrogenase 3 multiple interactions EXP [iprodione co-treated with Chlorpyrifos] results in decreased expression of HSD17B3 mRNA CTD PMID:33586219 NCBI chr17:1,027,229...1,058,554
Ensembl chr17:1,027,229...1,058,554
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression ISO iprodione results in increased expression of HSPA5 mRNA CTD PMID:16696176 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO [procymidone co-treated with iprodione co-treated with cyprodinil co-treated with fludioxonil co-treated with cyhalothrin] results in increased activity of NR1I2 protein; iprodione binds to and results in increased activity of NR1I2 protein CTD PMID:25028461 PMID:33049310 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
JBrowse link
G Nr5a1 nuclear receptor subfamily 5, group A, member 1 decreases expression
multiple interactions
EXP iprodione results in decreased expression of NR5A1 mRNA
iprodione promotes the reaction [Chlorpyrifos results in decreased expression of NR5A1 mRNA]
CTD PMID:33586219 NCBI chr 3:22,464,786...22,486,328
Ensembl chr 3:22,465,502...22,486,328
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma increases activity
multiple interactions
ISO iprodione results in increased activity of PPARG protein
iprodione binds to and results in increased activity of PPARG protein
CTD PMID:20143881 PMID:33049310 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha decreases expression
multiple interactions
EXP iprodione results in decreased expression of PPARGC1A mRNA
Chlorpyrifos promotes the reaction [iprodione results in decreased expression of PPARGC1A mRNA]; iprodione promotes the reaction [Chlorpyrifos results in decreased expression of PPARGC1A mRNA]
CTD PMID:33586219 NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656
JBrowse link
G Sirt1 sirtuin 1 multiple interactions
decreases expression
EXP [iprodione co-treated with Chlorpyrifos] results in decreased expression of SIRT1 mRNA
iprodione results in decreased expression of SIRT1 mRNA
CTD PMID:33586219 NCBI chr20:25,307,143...25,329,260
Ensembl chr20:25,306,917...25,329,260
JBrowse link
G Stmn1 stathmin 1 increases expression EXP iprodione results in increased expression of STMN1 mRNA CTD PMID:28576679 NCBI chr 5:146,680,757...146,687,154
Ensembl chr 5:146,681,436...146,687,154
JBrowse link
G Tert telomerase reverse transcriptase multiple interactions
decreases expression
EXP [iprodione co-treated with Chlorpyrifos] results in decreased expression of TERT mRNA
iprodione results in decreased expression of TERT mRNA
CTD PMID:33586219 NCBI chr 1:29,637,213...29,659,509
Ensembl chr 1:29,637,506...29,659,561
JBrowse link
G Thra thyroid hormone receptor alpha multiple interactions ISO iprodione binds to and results in increased activity of THRA protein CTD PMID:33049310 NCBI chr10:83,701,885...83,729,408
Ensembl chr10:83,700,755...83,729,936
JBrowse link
G Thrb thyroid hormone receptor beta multiple interactions ISO iprodione binds to and results in increased activity of THRB protein CTD PMID:33049310 NCBI chr15:7,685,180...8,031,920
Ensembl chr15:7,685,180...7,882,916
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Acetylcysteine inhibits the reaction [iprodione inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]]; iprodione inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein] CTD PMID:33226166 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
mephenytoin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases activity ISO Mephenytoin results in decreased activity of CYP1B1 protein CTD PMID:18420780 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 decreases activity ISO Mephenytoin results in decreased activity of CYP2B10 protein CTD PMID:18420780 NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 decreases methylation
decreases activity
multiple interactions
increases metabolic processing
ISO CYP2B6 protein results in decreased methylation of Mephenytoin
Mephenytoin results in decreased activity of CYP2B6 protein
Mephenytoin inhibits the reaction [[isoimperatorin co-treated with NADP] results in decreased activity of CYP2B6 protein]; Mephenytoin inhibits the reaction [CYP2B6 protein results in decreased ethylation of 7-ethoxy-4-trifluoromethylcoumarin]; Mephenytoin inhibits the reaction [CYP2B6 protein results in increased chemical synthesis of 7-hydroxy-4-trifluoromethylcoumarin]
CYP2B6 protein results in increased metabolism of Mephenytoin
CTD PMID:9241656 PMID:12433797 PMID:12464242 PMID:25500267 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 multiple interactions
increases metabolic processing
increases oxidation
affects hydroxylation
affects metabolic processing
increases hydroxylation
decreases activity
ISO 4-amino-2-phenoxymethanesulfonanilide inhibits the reaction [CYP2C19 protein results in increased oxidation of Mephenytoin]; [CYP2C19 protein results in increased metabolism of Mephenytoin] which results in increased chemical synthesis of 4-hydroxymephenytoin; [Mephenytoin results in decreased activity of CYP2C19 protein] which results in decreased degradation of vanoxerine; Fluoxetine inhibits the reaction [CYP2C19 protein results in increased hydroxylation of Mephenytoin]; Fluoxetine inhibits the reaction [CYP2C19 protein results in increased metabolism of Mephenytoin]; GH1 protein inhibits the reaction [CYP2C19 protein results in increased metabolism of Mephenytoin]; Lansoprazole inhibits the reaction [CYP2C19 protein results in increased hydroxylation of Mephenytoin]; Mephenytoin inhibits the reaction [CYP2C19 protein results in increased metabolism of 4,5-dihydropyrazole-1,5-dicarboxylic acid 1-((4-chlorophenyl)-amide) 5-(2-oxo-2H-(1,3')bipyridinyl-6'-yl)-amide]; Omeprazole inhibits the reaction [CYP2C19 protein results in increased hydroxylation of Mephenytoin]; Omeprazole inhibits the reaction [CYP2C19 protein results in increased metabolism of Mephenytoin]; Pantoprazole inhibits the reaction [CYP2C19 protein results in increased hydroxylation of Mephenytoin]; perfluorooctane sulfonic acid inhibits the reaction [CYP2C19 protein results in increased oxidation of Mephenytoin]; rabeprazole-thioether inhibits the reaction [CYP2C19 protein results in increased hydroxylation of Mephenytoin]; Resveratrol inhibits the reaction [CYP2C19 protein results in increased metabolism of Mephenytoin]; sitaxsentan inhibits the reaction [CYP2C19 protein results in increased metabolism of Mephenytoin]; Ticlopidine inhibits the reaction [CYP2C19 protein results in increased hydroxylation of Mephenytoin]; Ticlopidine inhibits the reaction [CYP2C19 protein results in increased metabolism of Mephenytoin]; Tranylcypromine inhibits the reaction [CYP2C19 protein results in increased metabolism of Mephenytoin]; ursolic acid inhibits the reaction [CYP2C19 protein results in increased metabolism of Mephenytoin]; zafirlukast inhibits the reaction [CYP2C19 protein results in increased metabolism of Mephenytoin]
CYP2C19 gene SNP affects the hydroxylation of Mephenytoin; CYP2C19 protein affects the hydroxylation of Mephenytoin
CYP2C19 protein affects the metabolism of Mephenytoin
CTD PMID:3577206 PMID:9170147 PMID:11502731 PMID:11907490 PMID:12401345 More... NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 decreases activity ISO Mephenytoin results in decreased activity of CYP2C29 protein CTD PMID:18420780
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 decreases activity ISO Mephenytoin results in decreased activity of CYP2E1 protein CTD PMID:18420780 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
JBrowse link
G Gh1 growth hormone 1 multiple interactions ISO GH1 protein inhibits the reaction [CYP2C19 protein results in increased metabolism of Mephenytoin] CTD PMID:11907490 NCBI chr10:91,228,102...91,230,079
Ensembl chr10:91,228,103...91,230,078
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO Mephenytoin binds to and results in increased activity of NR1I2 protein CTD PMID:15039302 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
JBrowse link
nitrofurantoin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 multiple interactions
decreases activity
ISO Nitrofurantoin inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
Nitrofurantoin results in decreased activity of ABCB11 protein
CTD PMID:24014644 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
JBrowse link
G Abcb4 ATP binding cassette subfamily B member 4 decreases activity ISO Nitrofurantoin results in decreased activity of ABCB4 protein CTD PMID:28437613 NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202
JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 affects transport
affects abundance
multiple interactions
increases secretion
increases transport
affects response to substance
increases export
ISO
EXP
ABCG2 protein affects the transport of Nitrofurantoin
ABCG2 protein affects the abundance of Nitrofurantoin
chrysin inhibits the reaction [ABCG2 protein affects the transport of Nitrofurantoin]; Elacridar inhibits the reaction [ABCG2 protein affects the transport of Nitrofurantoin]
ABCG2 protein results in increased secretion of Nitrofurantoin
ABCG2 protein results in increased transport of Nitrofurantoin
ABCG2 results in increased secretion of Nitrofurantoin
chrysin inhibits the reaction [ABCG2 protein results in increased transport of Nitrofurantoin]
ABCG2 affects the susceptibility to Nitrofurantoin
chrysin inhibits the reaction [ABCG2 protein results in increased transport of Nitrofurantoin]; Nitrofurantoin inhibits the reaction [ABCG2 protein results in increased export of bisbenzimide ethoxide trihydrochloride]
ABCG2 protein results in increased export of Nitrofurantoin
CTD PMID:15709111 PMID:15722455 PMID:17093006 PMID:17785426 PMID:18799806 More... NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409
JBrowse link
G Agt angiotensinogen decreases activity EXP Nitrofurantoin results in decreased activity of AGT protein CTD PMID:1313237 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
JBrowse link
G Aldoa aldolase, fructose-bisphosphate A increases expression EXP Nitrofurantoin results in increased expression of ALDOA mRNA; Nitrofurantoin results in increased expression of ALDOA protein CTD PMID:11841787 NCBI chr 1:181,402,275...181,407,476
Ensembl chr 1:181,402,275...181,406,182
JBrowse link
G Cat catalase decreases activity ISO
EXP
Nitrofurantoin results in decreased activity of CAT protein CTD PMID:1313237 PMID:9000262 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Cntf ciliary neurotrophic factor multiple interactions ISO Nitrofurantoin inhibits the reaction [CNTF protein results in increased phosphorylation of and results in increased activity of STAT1 protein]; Nitrofurantoin inhibits the reaction [CNTF protein results in increased phosphorylation of and results in increased activity of STAT3 protein]; Rotenone promotes the reaction [Nitrofurantoin inhibits the reaction [CNTF protein results in increased phosphorylation of and results in increased activity of STAT1 protein]]; Rotenone promotes the reaction [Nitrofurantoin inhibits the reaction [CNTF protein results in increased phosphorylation of and results in increased activity of STAT3 protein]] CTD PMID:15748169 NCBI chr 1:209,887,854...209,889,877
Ensembl chr 1:209,887,854...209,889,877
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO
EXP
Nitrofurantoin inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein] CTD PMID:18493746 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions ISO Nitrofurantoin inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A2 protein] CTD PMID:18493746 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions
increases expression
ISO NFE2L2 protein affects the reaction [Nitrofurantoin results in increased expression of GCLC protein]; POR protein affects the reaction [Nitrofurantoin results in increased expression of GCLC protein] CTD PMID:34021431 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
JBrowse link
G Gsr glutathione-disulfide reductase decreases activity
multiple interactions
EXP
ISO
Nitrofurantoin results in decreased activity of GSR protein
[Nitrofurantoin co-treated with GSR protein] affects the metabolism of Glucose
CTD PMID:1313237 PMID:1901343 PMID:9000262 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha increases activity EXP Nitrofurantoin results in increased activity of HIF1A protein CTD PMID:11841787 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
JBrowse link
G Hmox1 heme oxygenase 1 increases expression EXP Nitrofurantoin results in increased expression of HMOX1 mRNA CTD PMID:7626009 PMID:11841787 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Hsf1 heat shock transcription factor 1 increases activity ISO Nitrofurantoin results in increased activity of HSF1 protein CTD PMID:34170685 NCBI chr 7:108,196,040...108,223,011
Ensembl chr 7:108,196,056...108,223,011
JBrowse link
G Hspa8 heat shock protein family A (Hsp70) member 8 increases expression EXP Nitrofurantoin results in increased expression of HSPA8 mRNA CTD PMID:7626009 NCBI chr 8:41,183,397...41,187,260
Ensembl chr 8:41,183,264...41,187,259
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit increases expression EXP Nitrofurantoin results in increased expression of JUN mRNA CTD PMID:7626009 PMID:11841787 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
JBrowse link
G Lmcd1 LIM and cysteine-rich domains 1 increases expression EXP Nitrofurantoin results in increased expression of LMCD1 mRNA CTD PMID:23558518 NCBI chr 4:145,393,153...145,452,049
Ensembl chr 4:145,393,145...145,452,046
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions ISO NFE2L2 protein affects the reaction [Nitrofurantoin results in increased expression of GCLC protein]; Nitrofurantoin results in increased expression of and affects the localization of NFE2L2 protein; POR protein affects the reaction [Nitrofurantoin results in increased expression of NFE2L2 protein] CTD PMID:34021431 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases response to substance
affects reduction
ISO NQO1 protein results in increased susceptibility to Nitrofurantoin
NQO1 protein affects the reduction of Nitrofurantoin
CTD PMID:9310146 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Orm1 orosomucoid 1 increases expression EXP Nitrofurantoin results in increased expression of ORM1 mRNA; Nitrofurantoin results in increased expression of ORM1 protein CTD PMID:11841787 NCBI chr 5:76,766,637...76,776,149
Ensembl chr 5:76,772,941...76,776,154
JBrowse link
G Por cytochrome p450 oxidoreductase increases metabolic processing
multiple interactions
affects metabolic processing
ISO
EXP
POR protein results in increased metabolism of Nitrofurantoin
POR protein affects the reaction [Nitrofurantoin results in increased expression of GCLC protein]; POR protein affects the reaction [Nitrofurantoin results in increased expression of NFE2L2 protein]
diphenyleneiodonium inhibits the reaction [POR protein affects the metabolism of Nitrofurantoin]; NADP affects the reaction [POR protein affects the metabolism of Nitrofurantoin]; Nitrofurantoin inhibits the reaction [POR protein results in increased metabolism of Misonidazole]
CTD PMID:6802140 PMID:18206659 PMID:34021431 NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245
JBrowse link
G Stat1 signal transducer and activator of transcription 1 multiple interactions ISO Nitrofurantoin inhibits the reaction [CNTF protein results in increased phosphorylation of and results in increased activity of STAT1 protein]; Rotenone promotes the reaction [Nitrofurantoin inhibits the reaction [CNTF protein results in increased phosphorylation of and results in increased activity of STAT1 protein]] CTD PMID:15748169 NCBI chr 9:49,419,561...49,459,969 JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions
increases activity
increases expression
ISO
EXP
Nitrofurantoin inhibits the reaction [CNTF protein results in increased phosphorylation of and results in increased activity of STAT3 protein]; Rotenone promotes the reaction [Nitrofurantoin inhibits the reaction [CNTF protein results in increased phosphorylation of and results in increased activity of STAT3 protein]]
Nitrofurantoin results in increased activity of STAT3 protein
Nitrofurantoin results in increased expression of STAT3 mRNA
CTD PMID:11841787 PMID:15748169 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
JBrowse link
G Tgfb2 transforming growth factor, beta 2 increases expression EXP Nitrofurantoin results in increased expression of TGFB2 mRNA CTD PMID:23558518 NCBI chr13:98,160,075...98,261,771
Ensembl chr13:98,160,087...98,261,405
JBrowse link
G Tmprss2 transmembrane serine protease 2 increases expression ISO Nitrofurantoin results in increased expression of TMPRSS2 mRNA CTD PMID:32808185 NCBI chr11:36,934,306...36,973,779
Ensembl chr11:36,934,306...36,973,715
JBrowse link
phenytoin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aaas aladin WD repeat nucleoporin decreases expression EXP Phenytoin results in decreased expression of AAAS mRNA CTD PMID:20345932 NCBI chr 7:133,464,315...133,483,961
Ensembl chr 7:133,464,315...133,483,961
JBrowse link
G Abca1 ATP binding cassette subfamily A member 1 decreases expression ISO Phenytoin results in decreased expression of ABCA1 mRNA CTD PMID:15136057 NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170
JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A affects response to substance
multiple interactions
increases expression
increases transport
decreases activity
increases metabolic processing
affects abundance
ISO
EXP
ABCB1 protein affects the susceptibility to Phenytoin
Amino Acids, Peptides, and Proteins inhibits the reaction [Phenytoin results in increased expression of ABCB1 protein]; Phenytoin results in increased expression of and results in increased activity of ABCB1A protein
ABCB1A protein results in increased transport of Phenytoin
Phenytoin results in decreased activity of ABCB1 protein
ABCB1 protein results in increased metabolism of Phenytoin
ABCB1 protein affects the abundance of Phenytoin
CTD PMID:8001500 PMID:10580886 PMID:14749549 PMID:15569486 PMID:16220110 More... NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Abcb1b ATP-binding cassette, subfamily B (MDR/TAP), member 1B affects abundance ISO ABCB1B protein affects the abundance of Phenytoin CTD PMID:12122045 NCBI chr 4:25,242,761...25,325,194
Ensembl chr 4:25,242,798...25,325,199
JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 multiple interactions
increases expression
EXP KN 62 inhibits the reaction [Phenytoin results in increased expression of ABCC1 protein]; Tetradecanoylphorbol Acetate inhibits the reaction [Phenytoin results in increased expression of ABCC1 protein] CTD PMID:18473823 NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 affects transport
multiple interactions
increases expression
affects response to substance
EXP
ISO
ABCC2 protein affects the transport of Phenytoin
KN 62 inhibits the reaction [Phenytoin results in increased expression of ABCC2 protein]; Tetradecanoylphorbol Acetate inhibits the reaction [Phenytoin results in increased expression of ABCC2 protein]
ABCC2 protein affects the susceptibility to Phenytoin
CTD PMID:12663688 PMID:14636316 PMID:17376120 PMID:18473823 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 increases expression EXP Phenytoin results in increased expression of ABCC3 mRNA CTD PMID:17381134 NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595
JBrowse link
G Abcg1 ATP binding cassette subfamily G member 1 decreases expression ISO Phenytoin results in decreased expression of ABCG1 mRNA CTD PMID:15136057 NCBI chr20:9,126,687...9,182,948
Ensembl chr20:9,126,687...9,182,948
JBrowse link
G Abhd5 abhydrolase domain containing 5, lysophosphatidic acid acyltransferase increases expression EXP Phenytoin results in increased expression of ABHD5 mRNA CTD PMID:20345932 NCBI chr 8:122,000,241...122,026,447
Ensembl chr 8:122,000,389...122,026,447
JBrowse link
G Ablim1 actin-binding LIM protein 1 decreases expression ISO Phenytoin results in decreased expression of ABLIM1 mRNA CTD PMID:15136057 NCBI chr 1:256,084,293...256,372,075 JBrowse link
G Ace2 angiotensin I converting enzyme 2 decreases expression ISO Phenytoin results in decreased expression of ACE2 mRNA CTD PMID:32808185 NCBI chr  X:30,293,597...30,340,961
Ensembl chr  X:30,293,589...30,340,977
JBrowse link
G Ache acetylcholinesterase increases activity ISO Phenytoin results in increased activity of ACHE protein CTD PMID:16946593 NCBI chr12:19,407,359...19,413,713
Ensembl chr12:19,407,360...19,413,651
JBrowse link
G Adam8 ADAM metallopeptidase domain 8 decreases expression ISO Phenytoin results in decreased expression of ADAM8 mRNA CTD PMID:14741686 NCBI chr 1:194,776,559...194,789,330
Ensembl chr 1:194,770,060...194,788,801
JBrowse link
G Adamts9 ADAM metallopeptidase with thrombospondin type 1 motif, 9 increases expression EXP Phenytoin results in increased expression of ADAMTS9 mRNA CTD PMID:20345932 NCBI chr 4:125,290,633...125,462,988
Ensembl chr 4:125,291,490...125,462,929
JBrowse link
G Adgrb3 adhesion G protein-coupled receptor B3 increases expression EXP Phenytoin results in increased expression of ADGRB3 mRNA CTD PMID:20345932 NCBI chr 9:27,421,168...28,148,979
Ensembl chr 9:27,421,168...28,148,855
JBrowse link
G Adrb3 adrenoceptor beta 3 decreases expression EXP Phenytoin results in decreased expression of ADRB3 mRNA CTD PMID:20345932 NCBI chr16:64,839,820...64,844,552
Ensembl chr16:64,841,788...64,844,552
JBrowse link
G Afp alpha-fetoprotein decreases expression ISO Phenytoin results in decreased expression of AFP mRNA CTD PMID:14741686 PMID:26272751 NCBI chr14:17,573,412...17,591,476
Ensembl chr14:17,573,412...17,591,480
JBrowse link
G Agap3 ArfGAP with GTPase domain, ankyrin repeat and PH domain 3 decreases expression EXP Phenytoin results in decreased expression of AGAP3 mRNA CTD PMID:20345932 NCBI chr 4:10,674,064...10,724,848
Ensembl chr 4:10,674,064...10,725,244
JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions
increases expression
ISO
EXP
CYP3A11 protein affects the reaction [Phenytoin results in increased expression of AHR mRNA]
Ketoconazole inhibits the reaction [Phenytoin results in increased expression of AHR protein]
CTD PMID:17505019 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
JBrowse link
G Akap10 A-kinase anchoring protein 10 increases expression EXP Phenytoin results in increased expression of AKAP10 mRNA CTD PMID:20345932 NCBI chr10:46,545,464...46,608,768
Ensembl chr10:46,551,532...46,608,769
JBrowse link
G Akr7a3 aldo-keto reductase family 7 member A3 decreases expression
increases expression
EXP Phenytoin results in decreased expression of AKR7A3 mRNA
Phenytoin results in increased expression of AKR7A3 mRNA
CTD PMID:17381134 NCBI chr 5:151,590,968...151,601,394
Ensembl chr 5:151,584,479...151,601,394
JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 increases expression EXP Phenytoin results in increased expression of ALDH1A1 mRNA CTD PMID:17381134 NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961
JBrowse link
G Aldh1a2 aldehyde dehydrogenase 1 family, member A2 decreases expression ISO Phenytoin results in decreased expression of ALDH1A2 mRNA CTD PMID:31711903 NCBI chr 8:71,877,850...71,957,107
Ensembl chr 8:71,877,850...71,957,107
JBrowse link
G Amn1 antagonist of mitotic exit network 1 homolog increases expression EXP Phenytoin results in increased expression of AMN1 mRNA CTD PMID:20345932 NCBI chr 4:182,155,140...182,182,085
Ensembl chr 4:182,155,142...182,182,016
JBrowse link
G Anxa4 annexin A4 increases expression ISO Phenytoin results in increased expression of ANXA4 mRNA CTD PMID:14741686 NCBI chr 4:119,184,378...119,241,183
Ensembl chr 4:119,184,374...119,241,161
JBrowse link
G Anxa5 annexin A5 multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of ANXA5 mRNA CTD PMID:21224054 NCBI chr 2:119,314,007...119,344,703
Ensembl chr 2:119,314,007...119,353,369
JBrowse link
G Apoa1 apolipoprotein A1 increases expression ISO Phenytoin results in increased expression of APOA1 mRNA CTD PMID:15136057 NCBI chr 8:46,527,251...46,529,035
Ensembl chr 8:46,527,144...46,529,035
JBrowse link
G Apoa4 apolipoprotein A4 increases expression ISO Phenytoin results in increased expression of APOA4 mRNA CTD PMID:15136057 NCBI chr 8:46,539,083...46,541,464
Ensembl chr 8:46,539,082...46,541,469
JBrowse link
G Apoe apolipoprotein E increases expression ISO Phenytoin results in increased expression of APOE mRNA CTD PMID:15136057 NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932
JBrowse link
G Ar androgen receptor multiple interactions
increases expression
increases activity
ISO
EXP
[Phenytoin co-treated with Prednisolone] results in increased expression of AR protein
Phenytoin results in increased expression of AR protein
Ketoconazole inhibits the reaction [Phenytoin results in increased expression of AR protein]
Phenytoin results in increased expression of AR mRNA; Phenytoin results in increased expression of AR protein
Phenytoin results in increased activity of AR protein
CTD PMID:19226368 PMID:19490052 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925
JBrowse link
G Arfip1 ADP-ribosylation factor interacting protein 1 increases expression EXP Phenytoin results in increased expression of ARFIP1 mRNA CTD PMID:20345932 NCBI chr 2:169,843,804...169,924,136
Ensembl chr 2:169,843,801...169,923,142
JBrowse link
G Arhgap39 Rho GTPase activating protein 39 increases expression EXP Phenytoin results in increased expression of ARHGAP39 mRNA CTD PMID:20345932 NCBI chr 7:108,446,280...108,538,875
Ensembl chr 7:108,446,282...108,538,831
JBrowse link
G Armc8 armadillo repeat containing 8 increases expression EXP Phenytoin results in increased expression of ARMC8 mRNA CTD PMID:20345932 NCBI chr 8:100,036,946...100,131,544
Ensembl chr 8:100,036,946...100,131,520
JBrowse link
G Atm ATM serine/threonine kinase multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of ATM mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of ATM protein CTD PMID:21224054 NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437
JBrowse link
G Atpaf1 ATP synthase mitochondrial F1 complex assembly factor 1 decreases expression EXP Phenytoin results in decreased expression of ATPAF1 mRNA CTD PMID:20345932 NCBI chr 5:129,265,789...129,293,556
Ensembl chr 5:129,266,404...129,293,556
JBrowse link
G B4galt7 beta-1,4-galactosyltransferase 7 decreases expression EXP Phenytoin results in decreased expression of B4GALT7 mRNA CTD PMID:20345932 NCBI chr17:9,018,514...9,027,591
Ensembl chr17:9,018,935...9,027,573
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of BAX mRNA CTD PMID:21224054 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression
ISO Phenytoin results in increased expression of and affects the localization of BCL2 protein
Phenytoin results in decreased expression of BCL2 mRNA
CTD PMID:9118846 PMID:10695937 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of BCL2L1 mRNA CTD PMID:21224054 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
JBrowse link
G Bmp1 bone morphogenetic protein 1 decreases expression ISO Phenytoin results in decreased expression of BMP1 mRNA CTD PMID:14741686 NCBI chr15:45,551,603...45,595,862
Ensembl chr15:45,551,603...45,595,776
JBrowse link
G Bmp4 bone morphogenetic protein 4 increases expression ISO Phenytoin results in increased expression of BMP4 mRNA CTD PMID:16141649 NCBI chr15:19,618,538...19,633,494
Ensembl chr15:19,618,542...19,623,306
JBrowse link
G C2 complement C2 decreases expression EXP Phenytoin results in decreased expression of C2 mRNA CTD PMID:20345932 NCBI chr20:3,951,474...3,970,376
Ensembl chr20:3,951,474...3,976,505
JBrowse link
G Ca6 carbonic anhydrase 6 increases expression EXP Phenytoin results in increased expression of CAR6 mRNA CTD PMID:20345932 NCBI chr 5:160,658,104...160,676,644
Ensembl chr 5:160,658,105...160,676,644
JBrowse link
G Cacybp calcyclin binding protein increases expression EXP Phenytoin results in increased expression of CACYBP mRNA CTD PMID:20345932 NCBI chr13:72,437,485...72,447,810
Ensembl chr13:72,437,490...72,450,177
JBrowse link
G Calca calcitonin-related polypeptide alpha decreases expression EXP Phenytoin results in decreased expression of CALCA protein CTD PMID:2470235 NCBI chr 1:168,878,212...168,883,176
Ensembl chr 1:168,878,214...168,883,105
JBrowse link
G Calm2 calmodulin 2 decreases expression ISO Phenytoin results in decreased expression of CALM2 mRNA CTD PMID:14741686 NCBI chr 6:7,091,624...7,104,284
Ensembl chr 6:7,091,567...7,104,287
JBrowse link
G Capn5 calpain 5 decreases expression ISO Phenytoin results in decreased expression of CAPN5 mRNA CTD PMID:14741686 NCBI chr 1:152,416,252...152,472,923
Ensembl chr 1:152,416,252...152,472,923
JBrowse link
G Caskin1 CASK interacting protein 1 affects expression EXP Phenytoin affects the expression of CASKIN1 mRNA CTD PMID:20345932 NCBI chr10:13,512,684...13,533,380
Ensembl chr10:13,513,465...13,533,377
JBrowse link
G Cat catalase decreases response to substance ISO CAT protein results in decreased susceptibility to Phenytoin CTD PMID:21252394 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Cbll1 Cbl proto-oncogene like 1 increases expression EXP Phenytoin results in increased expression of CBLL1 mRNA CTD PMID:20345932 NCBI chr 6:48,071,190...48,086,174
Ensembl chr 6:48,071,190...48,086,444
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases expression EXP Phenytoin results in increased expression of CCL2 protein CTD PMID:14578793 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Ccnc cyclin C increases expression EXP Phenytoin results in increased expression of CCNC mRNA CTD PMID:20345932 NCBI chr 5:35,266,828...35,284,943
Ensembl chr 5:35,266,823...35,296,584
JBrowse link
G Ccnd1 cyclin D1 multiple interactions
decreases expression
ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of CCND1 mRNA
Phenytoin results in decreased expression of CCND1 mRNA
CTD PMID:14741686 PMID:21224054 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Ccng1 cyclin G1 multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of CCNG1 mRNA CTD PMID:21224054 NCBI chr10:25,176,231...25,182,604
Ensembl chr10:25,176,234...25,181,641
JBrowse link
G Cd47 Cd47 molecule decreases expression EXP Phenytoin results in decreased expression of CD47 mRNA CTD PMID:17381134 NCBI chr11:50,906,052...50,970,000
Ensembl chr11:50,906,177...50,969,425
JBrowse link
G Cdh2 cadherin 2 decreases expression ISO Phenytoin results in decreased expression of CDH2 mRNA CTD PMID:9118846 NCBI chr18:7,776,704...7,990,934
Ensembl chr18:7,776,704...7,990,167
JBrowse link
G Cdk1 cyclin-dependent kinase 1 decreases expression ISO Phenytoin results in decreased expression of CDK1 mRNA CTD PMID:26272751 NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A decreases expression
multiple interactions
ISO Phenytoin results in decreased expression of CDKN1A mRNA
[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of CDKN1A mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of CDKN1A protein
CTD PMID:14741686 PMID:21224054 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Cdx2 caudal type homeo box 2 increases expression EXP Phenytoin results in increased expression of CDX2 mRNA CTD PMID:20345932 NCBI chr12:7,726,798...7,733,142
Ensembl chr12:7,726,798...7,733,142
JBrowse link
G Cela2a chymotrypsin like elastase 2A decreases expression ISO Phenytoin results in decreased expression of CELA2A mRNA CTD PMID:14741686 NCBI chr 5:154,126,879...154,136,630
Ensembl chr 5:154,126,878...154,136,632
JBrowse link
G Cep57 centrosomal protein 57 increases expression EXP Phenytoin results in increased expression of CEP57 mRNA CTD PMID:20345932 NCBI chr 8:10,669,588...10,689,257
Ensembl chr 8:10,669,590...10,689,249
JBrowse link
G Cer1 cerberus 1, DAN family BMP antagonist decreases expression ISO Phenytoin results in decreased expression of CER1 mRNA CTD PMID:26272751 NCBI chr 5:97,306,427...97,309,783
Ensembl chr 5:97,306,431...97,309,783
JBrowse link
G Chek2 checkpoint kinase 2 multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of CHEK2 mRNA CTD PMID:21224054 NCBI chr12:45,788,823...45,821,382
Ensembl chr12:45,788,827...45,821,286
JBrowse link
G Ckm creatine kinase, M-type increases expression ISO Phenytoin results in increased expression of CKM protein CTD PMID:6682525 NCBI chr 1:79,061,390...79,071,721
Ensembl chr 1:79,061,456...79,071,720
JBrowse link
G Clcn6 chloride voltage-gated channel 6 decreases expression EXP Phenytoin results in decreased expression of CLCN6 mRNA CTD PMID:20345932 NCBI chr 5:158,434,299...158,465,174
Ensembl chr 5:158,434,299...158,465,059
JBrowse link
G Cmpk1 cytidine/uridine monophosphate kinase 1 increases expression EXP Phenytoin results in increased expression of CMPK1 mRNA CTD PMID:20345932 NCBI chr 5:128,480,301...128,507,830
Ensembl chr 5:128,480,301...128,507,830
JBrowse link
G Cnot7 CCR4-NOT transcription complex, subunit 7 increases expression EXP Phenytoin results in increased expression of CNOT7 mRNA CTD PMID:20345932 NCBI chr16:51,775,416...51,794,581
Ensembl chr16:51,775,412...51,794,576
JBrowse link
G Col11a1 collagen type XI alpha 1 chain increases expression ISO Phenytoin results in increased expression of COL11A1 mRNA CTD PMID:14741686 NCBI chr 2:201,820,715...202,013,853
Ensembl chr 2:201,820,715...202,013,853
JBrowse link
G Col18a1 collagen type XVIII alpha 1 chain decreases expression ISO Phenytoin results in decreased expression of COL18A1 mRNA CTD PMID:14741686 NCBI chr20:11,474,104...11,582,593
Ensembl chr20:11,474,104...11,582,593
JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions
increases expression
decreases expression
ISO Phenytoin inhibits the reaction [IL1B protein results in decreased expression of COL1A1 mRNA]
Phenytoin results in increased expression of COL1A1 mRNA
Phenytoin results in decreased expression of COL1A1 mRNA
CTD PMID:8971655 PMID:14741686 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
JBrowse link
G Col1a2 collagen type I alpha 2 chain increases expression
affects expression
ISO Phenytoin results in increased expression of COL1A2 mRNA
Phenytoin affects the expression of COL1A2 mRNA
CTD PMID:14741686 PMID:24704097 NCBI chr 4:32,563,938...32,598,868
Ensembl chr 4:32,563,381...32,598,867
JBrowse link
G Col6a1 collagen type VI alpha 1 chain decreases expression
increases expression
ISO Phenytoin results in decreased expression of COL6A1 mRNA
Phenytoin results in increased expression of COL6A1 mRNA
CTD PMID:8224229 PMID:14741686 NCBI chr20:11,906,105...11,924,599
Ensembl chr20:11,905,957...11,924,597
JBrowse link
G Col6a2 collagen type VI alpha 2 chain increases expression ISO Phenytoin results in increased expression of COL6A2 mRNA CTD PMID:8224229 NCBI chr20:12,021,676...12,049,425
Ensembl chr20:12,021,767...12,057,564
JBrowse link
G Col6a3 collagen type VI alpha 3 chain increases expression ISO Phenytoin results in increased expression of COL6A3 mRNA CTD PMID:8224229 NCBI chr 9:91,361,578...91,439,434
Ensembl chr 9:91,361,583...91,439,471
JBrowse link
G Cp ceruloplasmin decreases expression EXP Phenytoin results in decreased expression of CP mRNA CTD PMID:17381134 NCBI chr 2:102,439,433...102,498,075
Ensembl chr 2:102,439,624...102,498,075
JBrowse link
G Cpsf6 cleavage and polyadenylation specific factor 6 increases expression EXP Phenytoin results in increased expression of CPSF6 mRNA CTD PMID:20345932 NCBI chr 7:52,956,589...53,001,783
Ensembl chr 7:52,956,589...52,988,122
JBrowse link
G Crh corticotropin releasing hormone affects expression EXP Phenytoin affects the expression of CRH mRNA CTD PMID:20345932 NCBI chr 2:102,143,055...102,144,919
Ensembl chr 2:102,143,055...102,144,919
JBrowse link
G Crppa CDP-L-ribitol pyrophosphorylase A increases expression EXP Phenytoin results in increased expression of CRPPA mRNA CTD PMID:20345932 NCBI chr 6:53,120,264...53,397,030
Ensembl chr 6:53,121,438...53,397,028
JBrowse link
G Ctsb cathepsin B increases expression
decreases activity
ISO Phenytoin results in increased expression of CTSB mRNA
Phenytoin results in decreased activity of CTSB protein
CTD PMID:10914799 PMID:14741686 NCBI chr15:37,389,636...37,410,508
Ensembl chr15:37,389,629...37,410,500
JBrowse link
G Ctsl cathepsin L increases expression
decreases activity
ISO Phenytoin results in increased expression of CTSL mRNA
Phenytoin results in decreased activity of CTSL protein
CTD PMID:10914799 NCBI chr17:764,370...770,533
Ensembl chr17:764,309...770,548
JBrowse link
G Cul4a cullin 4A increases expression EXP Phenytoin results in increased expression of CUL4A mRNA CTD PMID:20345932 NCBI chr16:76,385,298...76,422,316
Ensembl chr16:76,384,546...76,422,330
JBrowse link
G Cx3cl1 C-X3-C motif chemokine ligand 1 increases expression EXP Phenytoin results in increased expression of CX3CL1 mRNA CTD PMID:20345932 NCBI chr19:10,227,337...10,237,826
Ensembl chr19:10,227,340...10,236,833
JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of CXCL10 mRNA CTD PMID:21224054 NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 multiple interactions ISO [Phenytoin co-treated with Buthionine Sulfoximine] results in increased expression of CXCL2 mRNA; Alprostadil inhibits the reaction [[Phenytoin co-treated with Buthionine Sulfoximine] results in increased expression of CXCL2 mRNA] CTD PMID:23986454 NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 decreases activity ISO Phenytoin results in decreased activity of CYP19A1 protein CTD PMID:17959350 NCBI chr 8:54,553,165...54,580,758
Ensembl chr 8:54,553,165...54,580,758
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression EXP
ISO
Phenytoin results in increased expression of CYP1A1 mRNA CTD PMID:9860486 PMID:17381134 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions ISO [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Phenytoin CTD PMID:23397584 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of CYP1B1 mRNA CTD PMID:21224054 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
JBrowse link
G Cyp2a3 cytochrome P450, family 2, subfamily a, polypeptide 3 multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of CYP2A5 mRNA CTD PMID:21224054 NCBI chr 1:82,171,914...82,179,980
Ensembl chr 1:82,169,949...82,179,979
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 decreases expression
increases expression
multiple interactions
EXP
ISO
Phenytoin results in decreased expression of CYP2B1 mRNA
Phenytoin results in decreased expression of CYP2B10 protein
Phenytoin results in increased expression of CYP2B1 mRNA
[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of CYP2B10 mRNA
CTD PMID:9819145 PMID:10945841 PMID:19226368 PMID:21224054 NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052
JBrowse link
G Cyp2b2 cytochrome P450, family 2, subfamily b, polypeptide 2 increases expression EXP Phenytoin results in increased expression of CYP2B2 mRNA CTD PMID:10945841 NCBI chr 1:81,594,534...81,608,567
Ensembl chr 1:81,594,555...81,608,566
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 multiple interactions
increases expression
increases activity
ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of CYP2B9 mRNA
Phenytoin results in increased expression of CYP2B9 protein
Phenytoin results in increased expression of CYP2B6 mRNA; Phenytoin results in increased expression of CYP2B6 protein
Phenytoin results in increased activity of CYP2B6 protein
[Phenytoin results in increased activity of NR1I3 protein alternative form] which results in increased expression of CYP2B6 mRNA; Dexamethasone promotes the reaction [NR3C1 protein affects the reaction [NR1I2 protein promotes the reaction [Phenytoin results in increased expression of CYP2B6 mRNA]]]; N-(3-(aminomethyl)benzyl)acetamidine inhibits the reaction [Phenytoin results in increased expression of CYP2B6 mRNA]; NOC 18 inhibits the reaction [Phenytoin results in increased expression of CYP2B6 protein]; NR1I2 protein affects the reaction [Phenytoin results in increased expression of and results in increased activity of CYP2B6 protein]; NR1I2 protein promotes the reaction [Phenytoin results in increased expression of CYP2B6 mRNA]; NR1I3 protein affects the reaction [Phenytoin results in increased expression of CYP2B6 mRNA]; Phenytoin results in increased expression of and results in increased activity of CYP2B6 protein; pimagedine inhibits the reaction [Phenytoin results in increased expression of CYP2B6 mRNA]
CTD PMID:12571232 PMID:12695351 PMID:14977870 PMID:15123723 PMID:17041008 More... NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 increases metabolic processing
affects metabolic processing
increases hydroxylation
increases activity
increases expression
increases response to substance
decreases metabolic processing
multiple interactions
decreases hydroxylation
EXP
ISO
CYP2C9 protein results in increased metabolism of Phenytoin
CYP2C9 protein affects the metabolism of Phenytoin; CYP2C9 protein alternative form affects the metabolism of Phenytoin
CYP2C9 protein results in increased hydroxylation of Phenytoin
Phenytoin results in increased activity of CYP2C9 protein
Phenytoin results in increased expression of CYP2C9 mRNA
CYP2C9 gene polymorphism results in increased susceptibility to Phenytoin
CYP2C9 5' UTR polymorphism results in decreased metabolism of Phenytoin; CYP2C9 gene polymorphism results in decreased metabolism of Phenytoin
[Clozapine results in decreased activity of CYP2C9 protein] which results in increased susceptibility to Phenytoin; [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Phenytoin; [CYP2C9 protein results in increased hydroxylation of Phenytoin] which results in increased abundance of hydroxyphenytoin; Miconazole inhibits the reaction [[CYP2C9 protein results in increased hydroxylation of Phenytoin] which results in increased abundance of hydroxyphenytoin]; Miconazole inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Phenytoin]; NR1I2 protein affects the reaction [Phenytoin results in increased expression of CYP2C9 mRNA]
CYP2C9 gene polymorphism results in decreased hydroxylation of Phenytoin
CTD PMID:2025243 PMID:9110362 PMID:9860067 PMID:10208645 PMID:10510154 More... NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 multiple interactions
affects metabolic processing
increases metabolic processing
decreases metabolic processing
increases hydroxylation
decreases hydroxylation
ISO
EXP
[CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Phenytoin
CYP2C19 protein affects the metabolism of Phenytoin
CYP2C19 protein results in increased metabolism of Phenytoin
CYP2C19 gene polymorphism results in decreased metabolism of Phenytoin
CYP2C19 protein results in increased hydroxylation of Phenytoin
CYP2C19 gene polymorphism results in decreased hydroxylation of Phenytoin
CTD PMID:9146858 PMID:9333104 PMID:9579299 PMID:9860067 PMID:15569425 More... NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 affects expression
increases expression
multiple interactions
ISO Phenytoin affects the expression of CYP2C29 mRNA
Phenytoin results in increased expression of CYP2C protein; Phenytoin results in increased expression of CYP2C29 mRNA; Phenytoin results in increased expression of CYP2C29 protein
[Phenytoin results in decreased activity of CYP2C29 protein] which results in decreased reduction of and results in decreased oxidation of 9-anthraldehyde; NR1I3 protein affects the reaction [Phenytoin results in increased expression of CYP2C29 mRNA]
CTD PMID:12051692 PMID:15155833 PMID:19136022 PMID:19903449 PMID:21766881
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 multiple interactions ISO [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Phenytoin CTD PMID:23397584 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions
decreases expression
increases expression
ISO
EXP
NOC 18 inhibits the reaction [Phenytoin results in increased expression of CYP2E1 mRNA]
Phenytoin results in decreased expression of CYP2E1 mRNA
Phenytoin results in increased expression of CYP2E1 mRNA; Phenytoin results in increased expression of CYP2E1 protein
CTD PMID:17381134 PMID:18206661 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases expression
multiple interactions
increases activity
EXP
ISO
Phenytoin results in increased expression of CYP3A2 mRNA; Phenytoin results in increased expression of CYP3A2 protein
[CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Phenytoin; N-Methyl-3,4-methylenedioxyamphetamine inhibits the reaction [Phenytoin promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA]]; NOC 18 inhibits the reaction [Phenytoin results in increased expression of CYP3A4 mRNA]; NR1I2 protein affects the reaction [Phenytoin results in increased expression of CYP3A4 mRNA]; NR3C1 protein promotes the reaction [Phenytoin results in increased expression of CYP3A4 mRNA]; Phenytoin promotes the reaction [CYP3A4 protein results in increased hydroxylation of Cholecalciferol]; Phenytoin promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA]
Phenytoin results in increased activity of CYP3A4 protein
Phenytoin results in increased expression of CYP3A4 mRNA; Phenytoin results in increased expression of CYP3A4 protein
Ketoconazole inhibits the reaction [Phenytoin results in increased expression of CYP3A2 protein]
CTD PMID:9512926 PMID:10219967 PMID:12065438 PMID:12505310 PMID:12673034 More... NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 decreases expression
increases expression
EXP Phenytoin results in decreased expression of CYP3A23-3A1 mRNA
Phenytoin results in increased expression of CYP3A23-3A1 mRNA
CTD PMID:10945841 PMID:17381134 NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030
JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 increases expression ISO Phenytoin results in increased expression of CYP3A5 mRNA
Phenytoin results in increased expression of CYP3A13 mRNA
CTD PMID:12673034 PMID:19903449 NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422
JBrowse link
G Cyp4a1 cytochrome P450, family 4, subfamily a, polypeptide 1 decreases expression EXP Phenytoin results in decreased expression of CYP4A1 mRNA CTD PMID:17381134 NCBI chr 5:129,123,323...129,137,464
Ensembl chr 5:129,123,336...129,137,464
JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of CYP7A1 mRNA CTD PMID:21224054 NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688
JBrowse link
G Cyp7b1 cytochrome P450 family 7 subfamily B member 1 increases expression EXP Phenytoin results in increased expression of CYP7B1 mRNA CTD PMID:20345932 NCBI chr 2:100,502,791...100,669,713
Ensembl chr 2:100,502,791...100,669,698
JBrowse link
G Dap3 death associated protein 3 increases expression ISO Phenytoin results in increased expression of DAP3 mRNA CTD PMID:14741686 NCBI chr 2:174,319,341...174,347,489
Ensembl chr 2:174,318,983...174,346,461
JBrowse link
G Dapk2 death-associated protein kinase 2 decreases expression ISO Phenytoin results in decreased expression of DAPK2 mRNA CTD PMID:14741686 NCBI chr 8:66,706,536...66,825,567
Ensembl chr 8:66,706,609...66,825,567
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of DDIT3 mRNA CTD PMID:21224054 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
JBrowse link
G Dhx9 DExH-box helicase 9 increases expression EXP Phenytoin results in increased expression of DHX9 mRNA CTD PMID:20345932 NCBI chr13:65,602,322...65,639,098
Ensembl chr13:65,602,323...65,639,069
JBrowse link
G Dmtn dematin actin binding protein decreases expression EXP Phenytoin results in decreased expression of DMTN mRNA CTD PMID:20345932 NCBI chr15:45,677,974...45,705,601
Ensembl chr15:45,677,977...45,705,601
JBrowse link
G Dnaja1 DnaJ heat shock protein family (Hsp40) member A1 multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of DNAJA1 mRNA CTD PMID:21224054 NCBI chr 5:55,842,414...55,853,326
Ensembl chr 5:55,842,426...55,853,967
JBrowse link
G E2f1 E2F transcription factor 1 multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of E2F1 mRNA CTD PMID:21224054 NCBI chr 3:143,064,535...143,075,362 JBrowse link
G Ebpl EBP like increases expression EXP Phenytoin results in increased expression of EBPL mRNA CTD PMID:20345932 NCBI chr15:35,508,074...35,531,472
Ensembl chr15:35,508,074...35,531,472
JBrowse link
G Egr1 early growth response 1 multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of EGR1 mRNA CTD PMID:21224054 NCBI chr18:26,463,333...26,465,531
Ensembl chr18:26,462,981...26,466,766
JBrowse link
G Egr3 early growth response 3 increases expression EXP Phenytoin results in increased expression of EGR3 mRNA CTD PMID:20345932 NCBI chr15:45,150,335...45,156,052
Ensembl chr15:45,150,567...45,154,627
JBrowse link
G Eif1a eukaryotic translation initiation factor 1A increases expression EXP Phenytoin results in increased expression of EIF1A mRNA CTD PMID:20345932 NCBI chr18:39,325,695...39,338,043
Ensembl chr18:39,325,202...39,338,696
JBrowse link
G Emx2 empty spiracles homeobox 2 decreases expression ISO Phenytoin results in decreased expression of EMX2 mRNA CTD PMID:9118846 NCBI chr 1:258,626,584...258,633,594
Ensembl chr 1:258,626,584...258,633,594
JBrowse link
G Enpep glutamyl aminopeptidase decreases expression
increases expression
EXP Phenytoin results in decreased expression of ENPEP mRNA
Phenytoin results in increased expression of ENPEP mRNA
CTD PMID:17381134 NCBI chr 2:217,781,985...217,851,947
Ensembl chr 2:217,782,005...217,851,947
JBrowse link
G Eomes eomesodermin increases expression ISO Phenytoin results in increased expression of EOMES mRNA CTD PMID:14741686 NCBI chr 8:118,181,340...118,189,186
Ensembl chr 8:118,181,777...118,188,316
JBrowse link
G Ephx1 epoxide hydrolase 1 affects response to substance
increases expression
ISO
EXP
EPHX1 gene polymorphism affects the susceptibility to Phenytoin
Phenytoin results in increased expression of EPHX1 mRNA
CTD PMID:17381134 PMID:19952982 NCBI chr13:92,714,315...92,744,124
Ensembl chr13:92,714,315...92,790,235
JBrowse link
G Ephx2 epoxide hydrolase 2 decreases expression EXP Phenytoin results in decreased expression of EPHX2 mRNA CTD PMID:17381134 NCBI chr15:40,289,901...40,327,632
Ensembl chr15:40,289,902...40,327,615
JBrowse link
G Esr1 estrogen receptor 1 increases expression ISO Phenytoin results in increased expression of ESR1 mRNA; Phenytoin results in increased expression of ESR1 protein CTD PMID:19490052 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Eya1 EYA transcriptional coactivator and phosphatase 1 decreases expression ISO Phenytoin results in decreased expression of EYA1 mRNA CTD PMID:31711903 NCBI chr 5:4,863,501...5,101,483
Ensembl chr 5:4,955,543...5,101,483
JBrowse link
G F10 coagulation factor X decreases expression EXP Phenytoin results in decreased expression of F10 mRNA CTD PMID:17381134 NCBI chr16:76,468,834...76,488,141
Ensembl chr16:76,468,838...76,488,141
JBrowse link
G F2 coagulation factor II multiple interactions ISO [clobazam co-treated with Phenytoin] results in increased expression of [F2 protein binds to SERPINC1 protein] CTD PMID:16376047 NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486
JBrowse link
G Faslg Fas ligand multiple interactions
decreases expression
ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of FASL mRNA; [Phenytoin co-treated with Buthionine Sulfoximine] results in decreased expression of FASL mRNA
Phenytoin results in decreased expression of FASL mRNA
CTD PMID:21224054 PMID:23986454 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215
JBrowse link
G Fbxl3 F-box and leucine-rich repeat protein 3 increases expression EXP Phenytoin results in increased expression of FBXL3 mRNA CTD PMID:20345932 NCBI chr15:79,906,795...79,926,678
Ensembl chr15:79,906,795...79,927,867
JBrowse link
G Fbxo30 F-box protein 30 increases expression EXP Phenytoin results in increased expression of FBXO30 mRNA CTD PMID:20345932 NCBI chr 1:5,655,341...5,671,558
Ensembl chr 1:5,655,339...5,672,441
JBrowse link
G Fgf12 fibroblast growth factor 12 increases expression EXP Phenytoin results in increased expression of FGF12 mRNA CTD PMID:20345932 NCBI chr11:71,997,049...72,564,965
Ensembl chr11:71,997,099...72,562,607
JBrowse link
G Fgf5 fibroblast growth factor 5 increases expression ISO Phenytoin results in increased expression of FGF5 mRNA CTD PMID:14741686 NCBI chr14:11,325,334...11,346,570
Ensembl chr14:11,325,334...11,345,997
JBrowse link
G Fgf8 fibroblast growth factor 8 increases expression ISO Phenytoin results in increased expression of FGF8 mRNA CTD PMID:31711903 NCBI chr 1:244,584,477...244,590,359
Ensembl chr 1:244,584,652...244,590,359
JBrowse link
G Fgf9 fibroblast growth factor 9 increases expression ISO Phenytoin results in increased expression of FGF9 mRNA CTD PMID:14741686 NCBI chr15:32,208,993...32,254,952
Ensembl chr15:32,210,074...32,253,309
JBrowse link
G Fgfr2 fibroblast growth factor receptor 2 increases expression ISO Phenytoin results in increased expression of FGFR2 mRNA; Phenytoin results in increased expression of FGFR2 protein CTD PMID:11352631 NCBI chr 1:184,745,418...184,850,655
Ensembl chr 1:184,745,420...184,850,626
JBrowse link
G Flrt2 fibronectin leucine rich transmembrane protein 2 increases expression ISO Phenytoin results in increased expression of FLRT2 mRNA CTD PMID:14741686 NCBI chr 6:114,777,547...114,872,688
Ensembl chr 6:114,777,599...114,872,785
JBrowse link
G Fmo1 flavin containing dimethylaniline monoxygenase 1 multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of FMO1 mRNA CTD PMID:21224054 NCBI chr13:75,182,184...75,214,439
Ensembl chr13:75,182,176...75,214,647
JBrowse link
G Fmo4 flavin containing dimethylaniline monoxygenase 4 multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of FMO4 mRNA CTD PMID:21224054 NCBI chr13:75,154,683...75,172,932
Ensembl chr13:75,154,684...75,172,874
JBrowse link
G Fmod fibromodulin decreases expression ISO Phenytoin results in decreased expression of FMOD mRNA CTD PMID:14741686 NCBI chr13:45,493,517...45,504,134
Ensembl chr13:45,493,517...45,504,133
JBrowse link
G Fmr1 FMRP translational regulator 1 increases expression EXP Phenytoin results in increased expression of FMR1 mRNA CTD PMID:20345932 NCBI chr  X:147,240,239...147,278,057
Ensembl chr  X:147,240,301...147,278,050
JBrowse link
G Fn1 fibronectin 1 increases expression ISO Phenytoin results in increased expression of FN1 mRNA CTD PMID:14741686 NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678
JBrowse link
G Fndc3a fibronectin type III domain containing 3a increases expression EXP Phenytoin results in increased expression of FNDC3A mRNA CTD PMID:20345932 NCBI chr15:47,689,909...47,867,354
Ensembl chr15:47,689,919...47,866,784
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions
decreases expression
EXP [Phenytoin co-treated with Drugs, Chinese Herbal] inhibits the reaction [Kainic Acid results in increased expression of FOS mRNA]
Phenytoin results in decreased expression of FOS protein
CTD PMID:7789465 PMID:8758711 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Foxc2 forkhead box C2 decreases expression ISO Phenytoin results in decreased expression of FOXC2 mRNA CTD PMID:31711903 NCBI chr19:49,186,034...49,188,736
Ensembl chr19:49,185,662...49,188,737
JBrowse link
G Foxp3 forkhead box P3 multiple interactions
decreases expression
ISO [Phenytoin co-treated with Buthionine Sulfoximine] results in decreased expression of FOXP3 mRNA
Phenytoin results in decreased expression of FOXP3 mRNA
CTD PMID:23986454 NCBI chr  X:14,908,494...14,924,994
Ensembl chr  X:14,908,494...14,923,838
JBrowse link
G Frs3 fibroblast growth factor receptor substrate 3 decreases expression ISO Phenytoin results in decreased expression of FRS3 mRNA CTD PMID:14741686 NCBI chr 9:13,288,559...13,297,285
Ensembl chr 9:13,288,667...13,295,382
JBrowse link
G G6pc1 glucose-6-phosphatase catalytic subunit 1 decreases expression EXP Phenytoin results in decreased expression of G6PC1 mRNA CTD PMID:17381134 NCBI chr10:86,307,400...86,318,766 JBrowse link
G G6pd glucose-6-phosphate dehydrogenase affects response to substance ISO G6PDX protein affects the susceptibility to Phenytoin CTD PMID:10627286 NCBI chr  X:152,201,081...152,220,863
Ensembl chr  X:152,201,098...152,220,801
JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of GADD45A mRNA CTD PMID:21224054 NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115
JBrowse link
G Gata3 GATA binding protein 3 multiple interactions
decreases expression
ISO [Phenytoin co-treated with Buthionine Sulfoximine] results in decreased expression of GATA3 mRNA
Phenytoin results in decreased expression of GATA3 mRNA
CTD PMID:23986454 NCBI chr17:68,643,760...68,666,000
Ensembl chr17:68,643,873...68,665,391
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression EXP Phenytoin results in increased expression of GCLM mRNA CTD PMID:20345932 NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535
JBrowse link
G Glul glutamate-ammonia ligase decreases activity ISO Phenytoin results in decreased activity of GLUL protein CTD PMID:10323596 NCBI chr13:65,969,064...66,035,121
Ensembl chr13:66,025,630...66,035,108
JBrowse link
G Gnl2 G protein nucleolar 2 increases expression EXP Phenytoin results in increased expression of GNL2 mRNA CTD PMID:20345932 NCBI chr 5:137,293,141...137,318,528
Ensembl chr 5:137,293,081...137,318,526
JBrowse link
G Gnpda2 glucosamine-6-phosphate deaminase 2 increases expression EXP Phenytoin results in increased expression of GNPDA2 mRNA CTD PMID:20345932 NCBI chr14:38,520,663...38,538,713
Ensembl chr14:38,520,705...38,538,713
JBrowse link
G Gpm6a glycoprotein m6a increases expression EXP Phenytoin results in increased expression of GPM6A mRNA CTD PMID:20345932 NCBI chr16:36,641,282...36,973,477
Ensembl chr16:36,641,284...36,973,475
JBrowse link
G Gpx2 glutathione peroxidase 2 multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of GPX2 mRNA CTD PMID:21224054 NCBI chr 6:95,493,589...95,496,877
Ensembl chr 6:95,493,589...95,496,877
JBrowse link
G Grin1 glutamate ionotropic receptor NMDA type subunit 1 increases expression EXP Phenytoin results in increased expression of GRIN1 mRNA CTD PMID:20345932 NCBI chr 3:8,103,680...8,130,603
Ensembl chr 3:8,103,680...8,130,603
JBrowse link
G Gsta1 glutathione S-transferase alpha 1 increases expression ISO Phenytoin results in increased expression of GSTA1 mRNA CTD PMID:11134551 NCBI chr 9:23,703,476...23,720,121
Ensembl chr 9:23,703,477...23,720,121
JBrowse link
G Gsta2 glutathione S-transferase alpha 2 increases expression
decreases expression
EXP Phenytoin results in increased expression of GSTA2 mRNA
Phenytoin results in decreased expression of GSTA2 mRNA
CTD PMID:17381134 NCBI chr 8:79,184,535...79,196,827
Ensembl chr 8:79,184,322...79,196,798
JBrowse link
G Gstk1 glutathione S-transferase kappa 1 decreases expression ISO Phenytoin results in decreased expression of GSTK1 mRNA CTD PMID:14741686 NCBI chr 4:71,118,979...71,123,298
Ensembl chr 4:71,118,896...71,123,292
JBrowse link
G Gstm1 glutathione S-transferase mu 1 increases expression
multiple interactions
EXP
ISO
Phenytoin results in increased expression of GSTM1 mRNA
[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of GSTM1 protein
CTD PMID:17381134 PMID:21224054 NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411
JBrowse link
G Gstm2 glutathione S-transferase mu 2 increases expression EXP Phenytoin results in increased expression of GSTM2 mRNA CTD PMID:17381134 NCBI chr 2:195,624,015...195,628,774 JBrowse link
G Gstm5 glutathione S-transferase, mu 5 multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of GSTM3 mRNA CTD PMID:21224054 NCBI chr 2:195,531,627...195,534,562
Ensembl chr 2:195,531,495...195,534,553
JBrowse link
G Gsto1 glutathione S-transferase omega 1 decreases expression ISO Phenytoin results in decreased expression of GSTO1 mRNA CTD PMID:14741686 NCBI chr 1:246,721,089...246,731,228
Ensembl chr 1:246,721,221...246,731,468
JBrowse link
G Gusb glucuronidase, beta multiple interactions
decreases activity
ISO Phenytoin inhibits the reaction [Misonidazole results in increased activity of GUSB protein]
Phenytoin results in decreased activity of GUSB protein
CTD PMID:6696821 NCBI chr12:26,701,191...26,714,718
Ensembl chr12:26,697,951...26,726,905
JBrowse link
G Hdac7 histone deacetylase 7 increases expression ISO Phenytoin results in increased expression of HDAC7 mRNA CTD PMID:26272751 NCBI chr 7:128,923,918...128,962,025
Ensembl chr 7:128,923,920...128,962,072
JBrowse link
G Helz helicase with zinc finger increases expression EXP Phenytoin results in increased expression of HELZ mRNA CTD PMID:20345932 NCBI chr10:92,479,403...92,645,234
Ensembl chr10:92,501,518...92,638,383
JBrowse link
G Hexim1 HEXIM P-TEFb complex subunit 1 increases expression EXP Phenytoin results in increased expression of HEXIM1 mRNA CTD PMID:20345932 NCBI chr10:88,062,808...88,064,920
Ensembl chr10:88,062,803...88,066,189
JBrowse link
G Hmgb1 high mobility group box 1 multiple interactions ISO [Phenytoin co-treated with Buthionine Sulfoximine] results in increased secretion of HMGB1 protein CTD PMID:23986454 NCBI chr12:5,973,062...5,978,565 JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression
ISO
EXP
[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of HMOX1 mRNA
Phenytoin results in increased expression of HMOX1 mRNA
CTD PMID:17381134 PMID:21224054 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Hnrnpa2b1 heterogeneous nuclear ribonucleoprotein A2/B1 increases expression EXP Phenytoin results in increased expression of HNRNPA2B1 mRNA CTD PMID:20345932 NCBI chr 4:80,534,659...80,545,297
Ensembl chr 4:80,534,651...80,545,249
JBrowse link
G Hook3 hook microtubule-tethering protein 3 increases expression EXP Phenytoin results in increased expression of HOOK3 mRNA CTD PMID:20345932 NCBI chr16:65,954,293...66,058,812 JBrowse link
G Hoxa2 homeobox A2 decreases expression ISO Phenytoin results in decreased expression of HOXA2 mRNA; Phenytoin results in decreased expression of HOXA2 protein CTD PMID:10789828
G Hoxb7 homeo box B7 increases expression ISO Phenytoin results in increased expression of HOXB7 mRNA CTD PMID:31711903 NCBI chr10:81,252,616...81,256,034
Ensembl chr10:81,252,553...81,256,034
JBrowse link
G Hoxb9 homeo box B9 increases expression ISO Phenytoin results in increased expression of HOXB9 mRNA CTD PMID:31711903 NCBI chr10:81,237,312...81,240,818
Ensembl chr10:81,237,312...81,240,818
JBrowse link
G Hspa1l heat shock protein family A (Hsp70) member 1 like multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of HSPA1L mRNA CTD PMID:21224054 NCBI chr20:3,848,843...3,855,571
Ensembl chr20:3,848,843...3,855,571
JBrowse link
G Hspa8 heat shock protein family A (Hsp70) member 8 multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of HSPA8 mRNA CTD PMID:21224054 NCBI chr 8:41,183,397...41,187,260
Ensembl chr 8:41,183,264...41,187,259
JBrowse link
G Hspb1 heat shock protein family B (small) member 1 multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of HSPB1 mRNA CTD PMID:21224054 NCBI chr12:20,794,014...20,795,675
Ensembl chr12:20,794,028...20,795,743
JBrowse link
G Hspd1 heat shock protein family D (Hsp60) member 1 multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of HSPD1 mRNA CTD PMID:21224054 NCBI chr 9:56,579,195...56,590,011
Ensembl chr 9:56,579,201...56,589,662
JBrowse link
G Hspe1 heat shock protein family E (Hsp10) member 1 multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of HSPE1 mRNA CTD PMID:21224054 NCBI chr 9:56,589,912...56,593,000
Ensembl chr 9:56,589,789...56,593,089
JBrowse link
G Ifng interferon gamma decreases expression ISO Phenytoin results in decreased expression of IFNG protein CTD PMID:10982153 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Ifngr1 interferon gamma receptor 1 increases expression ISO Phenytoin results in increased expression of IFNGR1 mRNA CTD PMID:14741686 NCBI chr 1:14,333,167...14,351,799
Ensembl chr 1:14,333,187...14,351,785
JBrowse link
G Ifngr2 interferon gamma receptor 2 increases expression ISO Phenytoin results in increased expression of IFNGR2 mRNA CTD PMID:14741686 NCBI chr11:30,779,733...30,798,005
Ensembl chr11:30,779,733...30,798,005
JBrowse link
G Igf1 insulin-like growth factor 1 decreases expression EXP Phenytoin results in decreased expression of IGF1 mRNA CTD PMID:17381134 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296
JBrowse link
G Igf2 insulin-like growth factor 2 increases expression ISO Phenytoin results in increased expression of IGF2 mRNA CTD PMID:9988880 NCBI chr 1:197,814,409...197,831,802
Ensembl chr 1:197,814,410...197,823,018
JBrowse link
G Ihh Indian hedgehog signaling molecule increases expression ISO Phenytoin results in increased expression of IHH mRNA CTD PMID:16141649 NCBI chr 9:76,504,315...76,510,532
Ensembl chr 9:76,504,315...76,510,532
JBrowse link
G Il17a interleukin 17A multiple interactions ISO [Phenytoin co-treated with Buthionine Sulfoximine] results in increased secretion of IL17A protein CTD PMID:23986454 NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889
JBrowse link
G Il18 interleukin 18 multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of IL18 mRNA CTD PMID:21224054 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Phenytoin inhibits the reaction [IL1B protein results in decreased expression of COL1A1 mRNA]
[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of IL1B mRNA; [Phenytoin co-treated with Buthionine Sulfoximine] results in increased expression of IL1B mRNA; [Phenytoin co-treated with Buthionine Sulfoximine] results in increased secretion of IL1B protein
CTD PMID:8971655 PMID:21224054 PMID:23986454 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il23a interleukin 23 subunit alpha multiple interactions ISO [Phenytoin co-treated with Buthionine Sulfoximine] results in increased expression of IL23A mRNA CTD PMID:23986454 NCBI chr 7:721,809...723,923
Ensembl chr 7:721,809...723,923
JBrowse link
G Il6 interleukin 6 multiple interactions
increases expression
ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of IL6 mRNA; [Phenytoin co-treated with Buthionine Sulfoximine] results in increased expression of IL6 mRNA
Phenytoin results in increased expression of IL6 mRNA
CTD PMID:21224054 PMID:23986454 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Il6r interleukin 6 receptor decreases expression ISO Phenytoin results in decreased expression of IL6RA mRNA CTD PMID:15136057 NCBI chr 2:175,289,157...175,347,719
Ensembl chr 2:175,298,686...175,347,536
JBrowse link
G Inpp5f inositol polyphosphate-5-phosphatase F increases expression EXP Phenytoin results in increased expression of INPP5F mRNA CTD PMID:20345932 NCBI chr 1:183,190,480...183,270,276
Ensembl chr 1:183,190,480...183,270,276
JBrowse link
G Insr insulin receptor increases expression ISO Phenytoin results in increased expression of INSR mRNA CTD PMID:14741686 NCBI chr12:1,193,193...1,330,976
Ensembl chr12:1,197,100...1,330,883
JBrowse link
G Ipp intracisternal A particle-promoted polypeptide increases expression EXP Phenytoin results in increased expression of IPP mRNA CTD PMID:20345932 NCBI chr 5:129,962,528...130,001,237
Ensembl chr 5:129,962,643...130,001,242
JBrowse link
G Irf9 interferon regulatory factor 9 increases expression EXP Phenytoin results in increased expression of IRF9 mRNA CTD PMID:20345932 NCBI chr15:29,095,474...29,101,924
Ensembl chr15:29,095,789...29,101,236
JBrowse link
G Itga2 integrin subunit alpha 2 decreases expression ISO Phenytoin results in decreased expression of ITGA2 protein CTD PMID:15948689 NCBI chr 2:46,520,345...46,621,487
Ensembl chr 2:46,523,948...46,621,481
JBrowse link
G Itga8 integrin subunit alpha 8 increases expression ISO Phenytoin results in increased expression of ITGA8 mRNA CTD PMID:14741686 NCBI chr17:75,304,004...75,501,510
Ensembl chr17:75,304,008...75,501,510
JBrowse link
G Itgb1 integrin subunit beta 1 decreases expression ISO Phenytoin results in decreased expression of ITGB1 protein CTD PMID:15948689 NCBI chr19:56,705,123...56,753,199
Ensembl chr19:56,705,171...56,753,195
JBrowse link
G Itgb3bp integrin subunit beta 3 binding protein increases expression EXP Phenytoin results in increased expression of ITGB3BP mRNA CTD PMID:20345932 NCBI chr 5:114,460,217...114,525,538
Ensembl chr 5:114,460,221...114,525,704
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit decreases expression ISO Phenytoin results in decreased expression of JUN mRNA CTD PMID:9118846 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
JBrowse link
G Kcnd2 potassium voltage-gated channel subfamily D member 2 increases expression EXP Phenytoin results in increased expression of KCND2 mRNA CTD PMID:20345932 NCBI chr 4:49,775,812...50,277,746
Ensembl chr 4:49,776,246...50,277,728
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO Phenytoin results in decreased activity of KCNH2 protein CTD PMID:21158687 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
JBrowse link
G Kctd3 potassium channel tetramerization domain containing 3 increases expression EXP Phenytoin results in increased expression of KCTD3 mRNA CTD PMID:20345932 NCBI chr13:100,510,193...100,548,765
Ensembl chr13:100,510,195...100,548,718
JBrowse link
G Kdr kinase insert domain receptor increases expression ISO Phenytoin results in increased expression of KDR mRNA CTD PMID:26272751 NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018
JBrowse link
G Khdrbs2 KH RNA binding domain containing, signal transduction associated 2 increases expression EXP Phenytoin results in increased expression of KHDRBS2 mRNA CTD PMID:20345932 NCBI chr 9:34,447,023...34,953,684
Ensembl chr 9:34,447,056...34,915,530
JBrowse link
G Klf2 Kruppel-like factor 2 increases expression EXP Phenytoin results in increased expression of KLF2 mRNA CTD PMID:20345932 NCBI chr16:17,521,773...17,523,723
Ensembl chr16:17,514,552...17,523,944
JBrowse link
G Klhl2 kelch-like family member 2 increases expression EXP Phenytoin results in increased expression of KLHL2 mRNA CTD PMID:20345932 NCBI chr16:24,860,763...24,973,348
Ensembl chr16:24,860,667...24,973,341
JBrowse link
G Klhl7 kelch-like family member 7 increases expression EXP Phenytoin results in increased expression of KLHL7 mRNA CTD PMID:20345932 NCBI chr 4:11,006,366...11,055,399
Ensembl chr 4:11,006,375...11,055,541
JBrowse link
G Krit1 KRIT1, ankyrin repeat containing increases expression EXP Phenytoin results in increased expression of KRIT1 mRNA CTD PMID:20345932 NCBI chr 4:30,299,203...30,333,366
Ensembl chr 4:30,299,203...30,333,359
JBrowse link
G Krt2 keratin 2 increases expression ISO Phenytoin results in increased expression of KRT2 mRNA CTD PMID:14741686 NCBI chr 7:132,941,275...132,947,963
Ensembl chr 7:132,940,862...132,947,963
JBrowse link
G Kyat1 kynurenine aminotransferase 1 increases activity EXP Phenytoin results in increased activity of KYAT1 protein CTD PMID:16765940 NCBI chr 3:13,459,598...13,493,308
Ensembl chr 3:13,459,591...13,493,355
JBrowse link
G Lama2 laminin subunit alpha 2 increases expression EXP Phenytoin results in increased expression of LAMA2 mRNA CTD PMID:20345932 NCBI chr 1:17,672,675...18,320,641
Ensembl chr 1:17,672,536...18,320,530
JBrowse link
G Lap3 leucine aminopeptidase 3 affects expression EXP Phenytoin affects the expression of LAP3 mRNA CTD PMID:20345932 NCBI chr14:65,608,375...65,627,359
Ensembl chr14:65,608,376...65,627,359
JBrowse link
G Lcat lecithin cholesterol acyltransferase increases expression ISO Phenytoin results in increased expression of LCAT mRNA CTD PMID:15136057 NCBI chr19:33,834,748...33,838,214
Ensembl chr19:33,834,403...33,838,231
JBrowse link
G Ldb2 LIM domain binding 2 increases expression EXP Phenytoin results in increased expression of LDB2 mRNA CTD PMID:20345932 NCBI chr14:66,277,044...66,598,071
Ensembl chr14:66,277,085...66,597,778
JBrowse link
G Lpin1 lipin 1 increases expression ISO Phenytoin results in increased expression of LPIN1 mRNA CTD PMID:14741686 NCBI chr 6:39,309,198...39,417,034
Ensembl chr 6:39,312,748...39,417,097
JBrowse link
G Lrba LPS responsive beige-like anchor protein increases expression EXP Phenytoin results in increased expression of LRBA mRNA CTD PMID:20345932 NCBI chr 2:171,623,668...172,202,576
Ensembl chr 2:171,621,507...172,202,724
JBrowse link
G Lsm1 LSM1 homolog, mRNA degradation associated decreases expression EXP Phenytoin results in decreased expression of LSM1 mRNA CTD PMID:20345932 NCBI chr16:66,277,345...66,288,852
Ensembl chr16:66,277,345...66,288,852
JBrowse link
G Ltbp4 latent transforming growth factor beta binding protein 4 increases expression EXP Phenytoin results in increased expression of LTBP4 mRNA CTD PMID:20345932 NCBI chr 1:82,600,136...82,634,346
Ensembl chr 1:82,600,136...82,632,178
JBrowse link
G Lypla1 lysophospholipase 1 increases expression EXP Phenytoin results in increased expression of LYPLA1 mRNA CTD PMID:20345932 NCBI chr 5:14,679,605...14,708,774
Ensembl chr 5:14,679,606...14,708,746
JBrowse link
G Map1b microtubule-associated protein 1B increases expression ISO Phenytoin results in increased expression of MAP1B mRNA CTD PMID:14741686 NCBI chr 2:30,817,261...30,910,458
Ensembl chr 2:30,817,261...30,910,317
JBrowse link
G Map3k4 mitogen activated protein kinase kinase kinase 4 increases expression EXP Phenytoin results in increased expression of MAP3K4 mRNA CTD PMID:20345932 NCBI chr 1:48,431,801...48,519,358
Ensembl chr 1:48,431,830...48,519,358
JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases phosphorylation ISO Phenytoin results in decreased phosphorylation of MAPK1 protein CTD PMID:15948689 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases phosphorylation ISO Phenytoin results in decreased phosphorylation of MAPK3 protein CTD PMID:15948689 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mapre3 microtubule-associated protein, RP/EB family, member 3 increases expression EXP Phenytoin results in increased expression of MAPRE3 mRNA CTD PMID:20345932 NCBI chr 6:25,513,800...25,558,876
Ensembl chr 6:25,513,800...25,558,881
JBrowse link
G Mbl1 mannose binding lectin 1 decreases expression EXP Phenytoin results in decreased expression of MBL1 mRNA CTD PMID:17381134 NCBI chr16:17,029,146...17,035,187
Ensembl chr16:17,029,118...17,035,174
JBrowse link
G Mdk midkine increases expression ISO Phenytoin results in increased expression of MDK mRNA CTD PMID:14741686 NCBI chr 3:77,901,156...77,903,997
Ensembl chr 3:77,901,158...77,903,130
JBrowse link
G Mdm2 MDM2 proto-oncogene multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of MDM2 mRNA CTD PMID:21224054 NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915
JBrowse link
G Me1 malic enzyme 1 increases expression EXP Phenytoin results in increased expression of ME1 mRNA CTD PMID:17381134 NCBI chr 8:87,549,043...87,660,251
Ensembl chr 8:87,549,043...87,660,304
JBrowse link
G Meox1 mesenchyme homeobox 1 decreases expression ISO Phenytoin results in decreased expression of MEOX1 mRNA CTD PMID:31711903 NCBI chr10:86,818,450...86,837,563
Ensembl chr10:86,818,478...86,837,660
JBrowse link
G Mesp1 mesoderm posterior bHLH transcription factor 1 increases expression ISO Phenytoin results in increased expression of MESP1 mRNA CTD PMID:26272751 NCBI chr 1:133,738,357...133,739,875
Ensembl chr 1:133,738,357...133,739,875
JBrowse link
G Mex3d mex-3 RNA binding family member D increases expression EXP Phenytoin results in increased expression of MEX3D mRNA CTD PMID:20345932 NCBI chr 7:9,325,575...9,332,705
Ensembl chr 7:9,325,488...9,332,096
JBrowse link
G Mgat2 alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase increases expression EXP Phenytoin results in increased expression of MGAT2 mRNA CTD PMID:20345932 NCBI chr 6:87,656,360...87,658,849
Ensembl chr 6:87,656,349...87,658,177
JBrowse link
G Mgmt O-6-methylguanine-DNA methyltransferase increases methylation ISO Phenytoin results in increased methylation of MGMT promoter CTD PMID:15949900 NCBI chr 1:191,710,980...191,937,760
Ensembl chr 1:191,710,930...191,937,756
JBrowse link
G Mki67 marker of proliferation Ki-67 multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC gene mutant form] results in increased expression of MKI67 protein CTD PMID:21224054 NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762
JBrowse link
G Mmp1 matrix metallopeptidase 1 decreases expression
increases expression
ISO Phenytoin results in decreased expression of MMP1 mRNA
Phenytoin results in increased expression of MMP1 mRNA
CTD PMID:10914799 PMID:14741686 PMID:15948689 NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097
JBrowse link
G Mmp2 matrix metallopeptidase 2 decreases expression ISO Phenytoin results in decreased expression of MMP2 mRNA CTD PMID:15948689 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
JBrowse link
G Mmp3 matrix metallopeptidase 3 decreases expression ISO Phenytoin results in decreased expression of MMP3 mRNA CTD PMID:15948689 NCBI chr 8:4,640,397...4,653,963
Ensembl chr 8:4,640,416...4,653,961
JBrowse link
G Mrps18c mitochondrial ribosomal protein S18C increases expression EXP Phenytoin results in increased expression of MRPS18C mRNA CTD PMID:20345932 NCBI chr14:8,812,301...8,818,538
Ensembl chr14:8,791,330...8,818,516
JBrowse link
G Mtf2 metal response element binding transcription factor 2 increases expression EXP Phenytoin results in increased expression of MTF2 mRNA CTD PMID:20345932 NCBI chr14:1,639,256...1,683,513
Ensembl chr14:1,640,746...1,683,524
JBrowse link
G Mthfd1l methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like increases expression EXP Phenytoin results in increased expression of MTHFD1L mRNA CTD PMID:20345932 NCBI chr 1:40,443,926...40,632,911
Ensembl chr 1:40,444,008...40,632,905
JBrowse link
G Mtx2 metaxin 2 increases expression EXP Phenytoin results in increased expression of MTX2 mRNA CTD PMID:20345932 NCBI chr 3:59,730,206...59,792,202
Ensembl chr 3:59,730,197...59,792,201
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor increases expression
decreases expression
ISO Phenytoin results in increased expression of MYC protein
Phenytoin results in decreased expression of MYC mRNA
CTD PMID:10695937 PMID:26272751 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
JBrowse link
G Myo1e myosin IE increases expression ISO Phenytoin results in increased expression of MYO1E mRNA CTD PMID:26272751 NCBI chr 8:70,887,934...71,080,180
Ensembl chr 8:70,887,870...71,080,169
JBrowse link
G Nap1l2 nucleosome assembly protein 1-like 2 affects expression EXP Phenytoin affects the expression of NAP1L2 mRNA CTD PMID:20345932 NCBI chr  X:68,174,051...68,176,449
Ensembl chr  X:68,173,987...68,176,666
JBrowse link
G Ncan neurocan increases expression ISO Phenytoin results in increased expression of NCAN mRNA CTD PMID:14741686 NCBI chr16:19,301,969...19,328,436
Ensembl chr16:19,301,969...19,328,436
JBrowse link
G Ncl nucleolin decreases expression EXP Phenytoin results in decreased expression of NCL mRNA CTD PMID:17381134 NCBI chr 9:86,999,588...87,008,112
Ensembl chr 9:86,998,019...87,008,136
JBrowse link
G Ncoa1 nuclear receptor coactivator 1 multiple interactions ISO Phenytoin promotes the reaction [NR1I3 protein modified form binds to NCOA1 protein] CTD PMID:21924250 NCBI chr 6:27,232,609...27,507,992
Ensembl chr 6:27,232,611...27,475,664
JBrowse link
G Nelfa negative elongation factor complex member A decreases expression EXP Phenytoin results in decreased expression of NELFA mRNA CTD PMID:20345932 NCBI chr14:76,808,920...76,832,998
Ensembl chr14:76,808,870...76,832,994
JBrowse link
G Nes nestin decreases expression ISO Phenytoin results in decreased expression of NES mRNA CTD PMID:26272751 NCBI chr 2:173,437,867...173,447,777
Ensembl chr 2:173,438,734...173,447,777
JBrowse link
G Neurog2 neurogenin 2 increases expression ISO Phenytoin results in increased expression of NEUROG2 mRNA CTD PMID:31711903 NCBI chr 2:216,092,641...216,095,276
Ensembl chr 2:216,093,363...216,094,154
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions
increases expression
ISO Phenytoin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased localization of and results in increased activity of NFKB1 protein]
Phenytoin results in increased expression of NFKB1 mRNA
CTD PMID:10700573 PMID:14741686 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
JBrowse link
G Nfkbia NFKB inhibitor alpha decreases degradation ISO Phenytoin results in decreased degradation of NFKBIA protein CTD PMID:15948689 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Ngly1 N-glycanase 1 increases expression EXP Phenytoin results in increased expression of NGLY1 mRNA CTD PMID:20345932 NCBI chr15:9,153,738...9,210,228
Ensembl chr15:9,153,738...9,204,630
JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions ISO [Phenytoin co-treated with Buthionine Sulfoximine] results in increased expression of NLRP3 mRNA CTD PMID:23986454 NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of NOS2 mRNA CTD PMID:21224054 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Npas2 neuronal PAS domain protein 2 increases expression EXP Phenytoin results in increased expression of NPAS2 mRNA CTD PMID:20345932 NCBI chr 9:41,463,361...41,642,322
Ensembl chr 9:41,463,830...41,642,320
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression EXP Phenytoin results in increased expression of NQO1 mRNA CTD PMID:17381134 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions
affects activity
increases expression
increases activity
ISO
EXP
Dexamethasone promotes the reaction [NR3C1 protein affects the reaction [NR1I2 protein promotes the reaction [Phenytoin results in increased expression of CYP2B6 mRNA]]]; N-Methyl-3,4-methylenedioxyamphetamine inhibits the reaction [Phenytoin promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA]]; NR1I2 protein affects the reaction [Phenytoin results in increased expression of and results in increased activity of CYP2B6 protein]; NR1I2 protein affects the reaction [Phenytoin results in increased expression of CYP2C9 mRNA]; NR1I2 protein affects the reaction [Phenytoin results in increased expression of CYP3A4 mRNA]; NR1I2 protein promotes the reaction [Phenytoin results in increased expression of CYP2B6 mRNA]; Phenytoin binds to and results in increased activity of NR1I2 protein; Phenytoin promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA]
Phenytoin affects the activity of NR1I2 protein
Phenytoin results in increased expression of NR1I2 protein
Phenytoin results in increased activity of NR1I2 protein
CTD PMID:12065438 PMID:12695340 PMID:12695351 PMID:14600250 PMID:14977870 More... NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions
increases expression
increases activity
increases localization
ISO
EXP
[Phenytoin results in increased activity of NR1I3 protein alternative form] which results in increased expression of CYP2B6 mRNA; NR1I3 protein affects the reaction [Phenytoin results in increased expression of CYP2B6 mRNA]; Phenytoin promotes the reaction [NR1I3 protein modified form binds to NCOA1 protein]
Phenytoin results in increased expression of NR1I3 protein
NR1I3 protein affects the reaction [Phenytoin results in increased expression of CYP2C29 mRNA]; NR1I3 protein affects the reaction [Phenytoin results in increased expression of CYP2C37 mRNA]
Phenytoin results in increased localization of NR1I3 protein
CTD PMID:15123723 PMID:15155833 PMID:15849716 PMID:16936065 PMID:17041008 More... NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
JBrowse link
G Nr2f1 nuclear receptor subfamily 2, group F, member 1 increases expression EXP Phenytoin results in increased expression of NR2F1 mRNA CTD PMID:20345932 NCBI chr 2:8,040,375...8,050,123
Ensembl chr 2:8,040,377...8,050,123
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 multiple interactions
increases expression
ISO
EXP
Dexamethasone promotes the reaction [NR3C1 protein affects the reaction [NR1I2 protein promotes the reaction [Phenytoin results in increased expression of CYP2B6 mRNA]]]; NR3C1 protein promotes the reaction [Phenytoin results in increased expression of CYP3A4 mRNA]
Phenytoin results in increased expression of NR3C1 mRNA
CTD PMID:10219967 PMID:12695351 PMID:20345932 NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375
JBrowse link
G Nrcam neuronal cell adhesion molecule decreases expression ISO Phenytoin results in decreased expression of NRCAM mRNA CTD PMID:26272751 NCBI chr 6:61,402,813...61,698,536
Ensembl chr 6:61,329,863...61,702,992
JBrowse link
G Nsmce3 NSE3 homolog, SMC5-SMC6 complex component increases expression EXP Phenytoin results in increased expression of NSMCE3 mRNA CTD PMID:20345932 NCBI chr 1:118,401,302...118,402,629 JBrowse link
G Nt5dc1 5'-nucleotidase domain containing 1 increases expression EXP Phenytoin results in increased expression of NT5DC1 mRNA CTD PMID:20345932 NCBI chr20:38,105,677...38,208,613
Ensembl chr20:38,105,678...38,208,591
JBrowse link
G Ntf3 neurotrophin 3 decreases expression ISO Phenytoin results in decreased expression of NTF3 mRNA CTD PMID:7841657 NCBI chr 4:158,914,984...158,984,453
Ensembl chr 4:158,914,957...158,984,596
JBrowse link
G Nup153 nucleoporin 153 increases expression EXP Phenytoin results in increased expression of NUP153 mRNA CTD PMID:20345932 NCBI chr17:17,972,217...18,024,876
Ensembl chr17:17,972,217...18,024,876
JBrowse link
G Olig3 oligodendrocyte transcription factor 3 increases expression ISO Phenytoin results in increased expression of OLIG3 mRNA CTD PMID:31711903 NCBI chr 1:14,081,259...14,083,336
Ensembl chr 1:14,081,328...14,082,149
JBrowse link
G Oprm1 opioid receptor, mu 1 multiple interactions ISO [cyprodime binds to and results in decreased activity of OPRM1 protein] which results in decreased susceptibility to Phenytoin CTD PMID:7870991 NCBI chr 1:43,160,057...43,413,409
Ensembl chr 1:43,160,057...43,413,409
JBrowse link
G Pafah1b1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 decreases expression ISO Phenytoin results in decreased expression of PAFAH1B1 mRNA CTD PMID:15136057 NCBI chr10:59,533,042...59,591,808
Ensembl chr10:59,534,117...59,591,808
JBrowse link
G Pafah1b2 platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 decreases expression ISO Phenytoin results in decreased expression of PAFAH1B2 mRNA CTD PMID:15136057 NCBI chr 8:46,260,069...46,312,073
Ensembl chr 8:46,261,064...46,279,833
JBrowse link
G Pard6g par-6 family cell polarity regulator gamma increases expression EXP Phenytoin results in increased expression of PARD6G mRNA CTD PMID:20345932 NCBI chr18:73,498,119...73,565,048
Ensembl chr18:73,498,021...73,565,029
JBrowse link
G Parg poly (ADP-ribose) glycohydrolase increases expression EXP Phenytoin results in increased expression of PARG mRNA CTD PMID:20345932 NCBI chr16:7,436,429...7,544,276
Ensembl chr16:7,436,476...7,544,273
JBrowse link
G Pax3 paired box 3 decreases expression ISO Phenytoin results in decreased expression of PAX3 mRNA CTD PMID:9118846 PMID:31711903 NCBI chr 9:79,567,455...79,664,042
Ensembl chr 9:79,568,634...79,664,042
JBrowse link
G Pax6 paired box 6 increases expression ISO Phenytoin results in increased expression of PAX6 mRNA CTD PMID:31711903 NCBI chr 3:92,128,772...92,157,022
Ensembl chr 3:92,135,637...92,157,014
JBrowse link
G Pbx1 PBX homeobox 1 increases expression EXP Phenytoin results in increased expression of PBX1 mRNA CTD PMID:20345932 NCBI chr13:80,278,766...80,588,563
Ensembl chr13:80,278,770...80,588,594
JBrowse link
G Pcyox1 prenylcysteine oxidase 1 increases expression EXP Phenytoin results in increased expression of PCYOX1 mRNA CTD PMID:20345932 NCBI chr 4:118,832,114...118,842,951
Ensembl chr 4:118,830,638...118,842,951
JBrowse link
G Pdgfa platelet derived growth factor subunit A increases expression ISO Phenytoin results in increased expression of PDGFA mRNA CTD PMID:14741686 NCBI chr12:15,645,549...15,667,056
Ensembl chr12:15,645,541...15,666,497
JBrowse link
G Pdgfb platelet derived growth factor subunit B increases expression EXP
ISO
Phenytoin results in increased expression of PDGFB mRNA; Phenytoin results in increased expression of PDGFB protein CTD PMID:8463938 PMID:9029455 PMID:14741686 NCBI chr 7:111,539,444...111,557,984
Ensembl chr 7:111,540,345...111,557,984
JBrowse link
G Pgrmc1 progesterone receptor membrane component 1 increases expression EXP Phenytoin results in increased expression of PGRMC1 mRNA CTD PMID:17381134 NCBI chr  X:115,832,865...115,841,060
Ensembl chr  X:115,832,884...115,888,682
JBrowse link
G Phf14 PHD finger protein 14 increases expression EXP Phenytoin results in increased expression of PHF14 mRNA CTD PMID:20345932 NCBI chr 4:40,009,691...40,195,870
Ensembl chr 4:40,009,264...40,195,885
JBrowse link
G Pip4k2a phosphatidylinositol-5-phosphate 4-kinase type 2 alpha increases expression ISO Phenytoin results in increased expression of PIP4K2A mRNA CTD PMID:14741686 NCBI chr17:81,496,669...81,668,180 JBrowse link
G Plaur plasminogen activator, urokinase receptor decreases expression ISO Phenytoin results in decreased expression of PLAUR mRNA CTD PMID:14741686 NCBI chr 1:80,053,441...80,068,384
Ensembl chr 1:80,050,324...80,068,595
JBrowse link
G Plcl1 phospholipase C-like 1 increases expression EXP Phenytoin results in increased expression of PLCL1 mRNA CTD PMID:20345932 NCBI chr 9:56,901,573...57,238,782
Ensembl chr 9:56,901,534...57,238,782
JBrowse link
G Plec plectin increases expression EXP Phenytoin results in increased expression of PLEC mRNA CTD PMID:20345932 NCBI chr 7:107,887,764...107,949,100
Ensembl chr 7:107,887,764...107,945,467
JBrowse link
G Pltp phospholipid transfer protein increases expression ISO Phenytoin results in increased expression of PLTP mRNA CTD PMID:15136057 NCBI chr 3:153,574,825...153,592,647
Ensembl chr 3:153,574,825...153,592,647
JBrowse link
G Plxnb2 plexin B2 decreases expression ISO Phenytoin results in decreased expression of PLXNB2 mRNA CTD PMID:14741686 NCBI chr 7:120,232,276...120,258,385
Ensembl chr 7:120,232,331...120,258,330
JBrowse link
G Pnn pinin, desmosome associated protein increases expression EXP Phenytoin results in increased expression of PNN mRNA CTD PMID:20345932 NCBI chr 6:76,758,138...76,766,451
Ensembl chr 6:76,758,117...76,766,889
JBrowse link
G Pon1 paraoxonase 1 decreases expression
affects activity
ISO Phenytoin results in decreased expression of PON1 mRNA
Phenytoin affects the activity of PON1 protein
CTD PMID:15136057 PMID:28032682 NCBI chr 4:33,294,737...33,325,759
Ensembl chr 4:33,294,722...33,321,360
JBrowse link
G Por cytochrome p450 oxidoreductase increases activity ISO Phenytoin results in increased activity of POR protein CTD PMID:12051692 NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245
JBrowse link
G Pou3f1 POU class 3 homeobox 1 increases expression ISO Phenytoin results in increased expression of POU3F1 protein CTD PMID:12781989 NCBI chr 5:136,910,391...136,913,371
Ensembl chr 5:136,910,391...136,913,371
JBrowse link
G Ppil4 peptidylprolyl isomerase like 4 increases expression EXP Phenytoin results in increased expression of PPIL4 mRNA CTD PMID:20345932 NCBI chr 1:2,273,582...2,306,212
Ensembl chr 1:2,273,609...2,305,632
JBrowse link
G Prkdc protein kinase, DNA-activated, catalytic subunit multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC gene mutant form] results in increased expression of MKI67 protein; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of ATM mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of ATM protein; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of CCND1 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of CHEK2 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of CYP1B1 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of CYP2A5 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of CYP2B9 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of CYP4A10 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of CYP4A14 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of CYP7A1 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of DNAJA1 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of EGR1 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of FASL mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of FMO1 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of FMO4 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of HSPD1 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of HSPE1 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of IL18 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of IL1B mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of RAD50 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of TNFSF10 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of TRADD mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of XRCC4 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of ANXA5 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of BAX mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of BCL2L1 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of CCNG1 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of CDKN1A mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of CDKN1A protein; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of CXCL10 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of CYP2B10 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of CYP3A11 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of CYP3A4 protein; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of DDIT3 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of E2F1 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of GADD45A mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of GPX2 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of GSTM1 protein; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of GSTM3 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of HMOX1 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of HSPA1L mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of HSPA8 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of HSPB1 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of IL6 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of MDM2 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of NOS2 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of SERPINE1 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of UNG mRNA; PRKDC gene mutant form results in increased susceptibility to [Rifampin co-treated with Phenytoin co-treated with Monocrotaline] CTD PMID:21224054 NCBI chr11:85,040,790...85,258,357
Ensembl chr11:85,040,792...85,257,952
JBrowse link
G Prl prolactin decreases expression EXP Phenytoin results in decreased expression of PRL mRNA; Phenytoin results in decreased expression of PRL protein CTD PMID:3734668 NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062
JBrowse link
G Prmt3 protein arginine methyltransferase 3 increases expression EXP Phenytoin results in increased expression of PRMT3 mRNA CTD PMID:20345932 NCBI chr 1:99,492,712...99,581,774
Ensembl chr 1:99,492,724...99,579,435
JBrowse link
G Prss12 serine protease 12 increases expression ISO Phenytoin results in increased expression of PRSS12 mRNA CTD PMID:14741686 NCBI chr 2:211,624,134...211,684,126
Ensembl chr 2:211,624,134...211,684,126
JBrowse link
G Psip1 PC4 and SFRS1 interacting protein 1 increases expression EXP Phenytoin results in increased expression of PSIP1 mRNA CTD PMID:20345932 NCBI chr 5:97,847,010...97,879,280
Ensembl chr 5:97,847,015...97,879,257
JBrowse link
G Psmc6 proteasome 26S subunit, ATPase 6 increases expression EXP Phenytoin results in increased expression of PSMC6 mRNA CTD PMID:20345932 NCBI chr15:18,542,585...18,564,057
Ensembl chr15:18,542,563...18,564,055
JBrowse link
G Psmd12 proteasome 26S subunit, non-ATPase 12 increases expression EXP Phenytoin results in increased expression of PSMD12 mRNA CTD PMID:20345932 NCBI chr10:92,438,223...92,457,323
Ensembl chr10:92,438,298...92,457,287
JBrowse link
G Ptbp2 polypyrimidine tract binding protein 2 increases expression EXP Phenytoin results in increased expression of PTBP2 mRNA CTD PMID:20345932 NCBI chr 2:207,812,659...207,874,019
Ensembl chr 2:207,812,920...207,873,506
JBrowse link
G Ptch1 patched 1 increases expression ISO Phenytoin results in increased expression of PTCH1 mRNA CTD PMID:16141649 NCBI chr17:1,542,705...1,607,730
Ensembl chr17:1,542,877...1,607,333
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression EXP Phenytoin results in increased expression of PTGS2 mRNA CTD PMID:20345932 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Pth parathyroid hormone increases expression ISO Phenytoin results in increased expression of PTH protein CTD PMID:20683115 NCBI chr 1:167,508,121...167,511,530
Ensembl chr 1:167,508,598...167,511,530
JBrowse link
G Rad50 RAD50 double strand break repair protein multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of RAD50 mRNA CTD PMID:21224054 NCBI chr10:37,809,353...37,861,309
Ensembl chr10:37,808,726...37,861,396
JBrowse link
G Rai1 retinoic acid induced 1 increases expression EXP Phenytoin results in increased expression of RAI1 mRNA CTD PMID:20345932 NCBI chr10:44,913,231...45,008,232
Ensembl chr10:44,947,909...45,008,232
JBrowse link
G Ranbp6 RAN binding protein 6 increases expression EXP Phenytoin results in increased expression of RANBP6 mRNA CTD PMID:20345932 NCBI chr 1:227,572,394...227,576,915
Ensembl chr 1:227,572,105...227,576,942
JBrowse link
G Rapgef4 Rap guanine nucleotide exchange factor 4 increases expression EXP Phenytoin results in increased expression of RAPGEF4 mRNA CTD PMID:20345932 NCBI chr 3:56,809,388...57,101,332
Ensembl chr 3:56,809,270...57,102,316
JBrowse link
G Rara retinoic acid receptor, alpha increases expression
decreases expression
ISO Phenytoin results in increased expression of RARA mRNA
Phenytoin results in decreased expression of RARA mRNA
CTD PMID:9118846 PMID:9988880 NCBI chr10:83,883,490...83,928,932
Ensembl chr10:83,893,384...83,928,142
JBrowse link
G Rarb retinoic acid receptor, beta increases expression ISO Phenytoin results in increased expression of RARB mRNA CTD PMID:9988880 NCBI chr15:8,700,533...9,051,288
Ensembl chr15:8,406,492...9,051,288
JBrowse link
G Rarg retinoic acid receptor, gamma increases expression ISO Phenytoin results in increased expression of RARG mRNA CTD PMID:9988880 NCBI chr 7:133,367,833...133,390,301
Ensembl chr 7:133,367,833...133,390,177
JBrowse link
G Rbm12 RNA binding motif protein 12 increases expression EXP Phenytoin results in increased expression of RBM12 mRNA CTD PMID:20345932 NCBI chr 3:144,587,548...144,629,950
Ensembl chr 3:144,611,623...144,629,915
JBrowse link
G Rbm3 RNA binding motif protein 3 increases expression EXP Phenytoin results in increased expression of RBM3 mRNA CTD PMID:20345932 NCBI chr  X:14,348,909...14,352,387
Ensembl chr  X:14,348,910...14,353,580
JBrowse link
G Rbm34 RNA binding motif protein 34 increases expression EXP Phenytoin results in increased expression of RBM34 mRNA CTD PMID:20345932 NCBI chr19:54,936,516...54,956,810
Ensembl chr19:54,936,531...54,956,715
JBrowse link
G Rbp2 retinol binding protein 2 increases expression ISO Phenytoin results in increased expression of RBP2 mRNA CTD PMID:9118846 NCBI chr 8:99,079,293...99,104,489
Ensembl chr 8:99,079,104...99,104,473
JBrowse link
G Rdh14 retinol dehydrogenase 14 increases expression EXP Phenytoin results in increased expression of RDH14 mRNA CTD PMID:20345932 NCBI chr 6:33,156,569...33,161,712
Ensembl chr 6:33,156,569...33,161,712
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
increases activity
ISO Phenytoin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased localization of and results in increased activity of RELA protein]
Phenytoin results in increased activity of RELA protein
CTD PMID:10700573 PMID:15322231 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Rhoa ras homolog family member A decreases expression ISO Phenytoin results in decreased expression of RHOA mRNA CTD PMID:15136057 NCBI chr 8:108,991,926...109,025,746
Ensembl chr 8:108,991,954...109,025,746
JBrowse link
G Riok2 RIO kinase 2 increases expression EXP Phenytoin results in increased expression of RIOK2 mRNA CTD PMID:20345932 NCBI chr 1:58,103,132...58,119,397
Ensembl chr 1:58,103,084...58,120,512
JBrowse link
G Rnaseh1 ribonuclease H1 decreases expression EXP Phenytoin results in decreased expression of RNASEH1 mRNA CTD PMID:20345932 NCBI chr 6:45,282,849...45,292,258
Ensembl chr 6:45,282,854...45,292,236
JBrowse link
G Rnd1 Rho family GTPase 1 increases expression EXP Phenytoin results in increased expression of RND1 mRNA CTD PMID:20345932 NCBI chr 7:129,821,311...129,828,385
Ensembl chr 7:129,821,311...129,828,399
JBrowse link
G Rnf115 ring finger protein 115 increases expression EXP Phenytoin results in increased expression of RNF115 mRNA CTD PMID:20345932 NCBI chr 2:184,262,087...184,329,841
Ensembl chr 2:184,262,371...184,329,823
JBrowse link
G Rpe ribulose-5-phosphate-3-epimerase increases expression EXP Phenytoin results in increased expression of RPE mRNA CTD PMID:20345932 NCBI chr 9:68,191,027...68,211,295
Ensembl chr 9:68,191,292...68,211,591
JBrowse link
G Rpl28 ribosomal protein L28 increases expression ISO Phenytoin results in increased expression of RPL28 mRNA CTD PMID:14741686 NCBI chr 1:69,052,148...69,054,735
Ensembl chr 1:69,053,203...69,055,032
JBrowse link
G Rps6ka3 ribosomal protein S6 kinase A3 increases expression EXP Phenytoin results in increased expression of RPS6KA3 mRNA CTD PMID:20345932 NCBI chr  X:35,517,306...35,623,296
Ensembl chr  X:35,517,306...35,623,207
JBrowse link
G Rpsa ribosomal protein SA increases expression ISO Phenytoin results in increased expression of RPSA mRNA CTD PMID:14741686 NCBI chr 8:119,851,225...119,855,103
Ensembl chr 8:119,851,225...119,855,247
JBrowse link
G Rsrc1 arginine and serine rich coiled-coil 1 decreases expression EXP Phenytoin results in decreased expression of RSRC1 mRNA CTD PMID:20345932 NCBI chr 2:151,226,821...151,632,771
Ensembl chr 2:151,231,156...151,632,765
JBrowse link
G Ryr2 ryanodine receptor 2 increases expression EXP Phenytoin results in increased expression of RYR2 mRNA CTD PMID:20345932 NCBI chr17:58,389,925...58,975,641
Ensembl chr17:58,389,925...58,975,142
JBrowse link
G S100a10 S100 calcium binding protein A10 increases expression ISO Phenytoin results in increased expression of S100A10 mRNA CTD PMID:14741686 NCBI chr 2:179,221,012...179,229,659
Ensembl chr 2:179,220,887...179,229,661
JBrowse link
G S100a4 S100 calcium-binding protein A4 increases expression ISO Phenytoin results in increased expression of S100A4 mRNA CTD PMID:14741686 NCBI chr 2:176,090,951...176,093,258
Ensembl chr 2:176,091,804...176,093,254
JBrowse link
G S100a8 S100 calcium binding protein A8 multiple interactions ISO [Phenytoin co-treated with Buthionine Sulfoximine] results in increased expression of S100A8 mRNA CTD PMID:23986454 NCBI chr 2:176,166,517...176,167,645
Ensembl chr 2:176,167,124...176,167,643
JBrowse link
G S100a9 S100 calcium binding protein A9 multiple interactions
increases expression
ISO [Phenytoin co-treated with Buthionine Sulfoximine] results in increased expression of S100A9 mRNA
Phenytoin results in increased expression of S100A9 mRNA
CTD PMID:23986454 NCBI chr 2:176,190,361...176,193,182
Ensembl chr 2:176,190,361...176,193,230
JBrowse link
G Sart3 spliceosome associated factor 3, U4/U6 recycling protein increases expression EXP Phenytoin results in increased expression of SART3 mRNA CTD PMID:20345932 NCBI chr12:42,859,026...42,887,041
Ensembl chr12:42,859,305...42,887,038
JBrowse link
G Sc5d sterol-C5-desaturase increases expression ISO Phenytoin results in increased expression of SC5D mRNA CTD PMID:14741686 NCBI chr 8:42,629,649...42,641,257
Ensembl chr 8:42,632,672...42,641,273
JBrowse link
G Scaf1 SR-related CTD-associated factor 1 increases expression EXP Phenytoin results in increased expression of SCAF1 mRNA CTD PMID:20345932 NCBI chr 1:95,485,448...95,499,389
Ensembl chr 1:95,485,448...95,496,029
JBrowse link
G Scarb1 scavenger receptor class B, member 1 decreases expression ISO Phenytoin results in decreased expression of SCARB1 mRNA CTD PMID:15136057 NCBI chr12:31,296,143...31,362,649
Ensembl chr12:31,296,156...31,362,647
JBrowse link
G Scn1a sodium voltage-gated channel alpha subunit 1 affects response to substance ISO SCN1A gene polymorphism affects the susceptibility to Phenytoin; SCN1A protein affects the susceptibility to Phenytoin CTD PMID:15805193 PMID:17001291 NCBI chr 3:50,952,790...51,071,804
Ensembl chr 3:50,952,791...51,071,699
JBrowse link
G Scn1b sodium voltage-gated channel beta subunit 1 affects binding
decreases response to substance
multiple interactions
ISO Phenytoin binds to [SCN1B protein binds to SCN3A protein]
SCN1B protein mutant form results in decreased susceptibility to Phenytoin
Phenytoin results in decreased activity of [SCN1B protein binds to SCN3A protein]
CTD PMID:15922564 NCBI chr 1:86,353,917...86,363,836
Ensembl chr 1:86,353,917...86,363,739
JBrowse link
G Scn2a sodium voltage-gated channel alpha subunit 2 decreases activity ISO Phenytoin results in decreased activity of SCN2A protein CTD PMID:11212204 NCBI chr 3:50,302,781...50,437,504
Ensembl chr 3:50,302,877...50,437,214
JBrowse link
G Scn3a sodium voltage-gated channel alpha subunit 3 multiple interactions
affects binding
ISO Phenytoin results in decreased activity of [SCN1B protein binds to SCN3A protein]
Phenytoin binds to [SCN1B protein binds to SCN3A protein]
CTD PMID:15922564 NCBI chr 3:50,146,411...50,258,119
Ensembl chr 3:50,148,139...50,258,119
JBrowse link
G Sdc4 syndecan 4 decreases expression ISO Phenytoin results in decreased expression of SDC4 mRNA CTD PMID:15136057 NCBI chr 3:153,154,888...153,173,576
Ensembl chr 3:153,154,896...153,173,580
JBrowse link
G Sele selectin E multiple interactions ISO [clobazam co-treated with Phenytoin] results in increased expression of SELE protein CTD PMID:16376047 NCBI chr13:76,402,841...76,412,741
Ensembl chr13:76,403,304...76,412,741
JBrowse link
G Senp7 SUMO specific peptidase 7 increases expression EXP Phenytoin results in increased expression of SENP7 mRNA CTD PMID:20345932 NCBI chr11:44,423,735...44,584,129
Ensembl chr11:44,423,735...44,564,711
JBrowse link
G Serpinc1 serpin family C member 1 multiple interactions ISO [clobazam co-treated with Phenytoin] results in increased expression of [F2 protein binds to SERPINC1 protein] CTD PMID:16376047 NCBI chr13:73,257,208...73,271,476
Ensembl chr13:73,257,179...73,284,293
JBrowse link
G Serpine1 serpin family E member 1 multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of SERPINE1 mRNA CTD PMID:21224054 NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657
JBrowse link
G Sh3yl1 SH3 and SYLF domain containing 1 increases expression EXP Phenytoin results in increased expression of SH3YL1 mRNA CTD PMID:20345932 NCBI chr 6:47,522,098...47,565,858
Ensembl chr 6:47,522,091...47,565,858
JBrowse link
G Shh sonic hedgehog signaling molecule increases expression ISO Phenytoin results in increased expression of SHH mRNA CTD PMID:26272751 NCBI chr 4:6,954,017...6,963,170
Ensembl chr 4:6,954,017...6,963,170
JBrowse link
G Siah1 siah E3 ubiquitin protein ligase 1 increases expression EXP Phenytoin results in increased expression of SIAH1A mRNA CTD PMID:20345932 NCBI chr19:20,378,908...20,402,512
Ensembl chr19:20,378,439...20,403,808
JBrowse link
G Sipa1l1 signal-induced proliferation-associated 1 like 1 increases expression EXP Phenytoin results in increased expression of SIPA1L1 mRNA CTD PMID:20345932 NCBI chr 6:101,839,351...102,118,408
Ensembl chr 6:101,839,404...102,116,950
JBrowse link
G Slc22a7 solute carrier family 22 member 7 decreases expression EXP Phenytoin results in decreased expression of SLC22A7 mRNA CTD PMID:17381134 NCBI chr 9:14,547,073...14,554,354
Ensembl chr 9:14,547,849...14,553,921
JBrowse link
G Slc4a3 solute carrier family 4 member 3 increases expression EXP Phenytoin results in increased expression of SLC4A3 mRNA CTD PMID:20345932 NCBI chr 9:77,036,243...77,053,940
Ensembl chr 9:77,037,016...77,049,105
JBrowse link
G Smarca1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 increases expression EXP Phenytoin results in increased expression of SMARCA1 mRNA CTD PMID:20345932 NCBI chr  X:126,980,201...127,066,385
Ensembl chr  X:126,994,947...127,066,347
JBrowse link
G Smarca5 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 increases expression EXP Phenytoin results in increased expression of SMARCA5 mRNA CTD PMID:20345932 NCBI chr19:27,271,918...27,304,594
Ensembl chr19:27,271,148...27,304,594
JBrowse link
G Smc2 structural maintenance of chromosomes 2 increases expression EXP Phenytoin results in increased expression of SMC2 mRNA CTD PMID:20345932 NCBI chr 5:66,806,882...66,853,478
Ensembl chr 5:66,807,011...66,853,242
JBrowse link
G Smc3 structural maintenance of chromosomes 3 increases expression ISO Phenytoin results in increased expression of SMC3 mRNA CTD PMID:14741686 NCBI chr 1:252,601,422...252,644,522
Ensembl chr 1:252,601,753...252,644,522
JBrowse link
G Smc5 structural maintenance of chromosomes 5 increases expression EXP Phenytoin results in increased expression of SMC5 mRNA CTD PMID:20345932 NCBI chr 1:220,769,366...220,839,138
Ensembl chr 1:220,769,366...220,839,096
JBrowse link
G Snx2 sorting nexin 2 increases expression EXP Phenytoin results in increased expression of SNX2 mRNA CTD PMID:20345932 NCBI chr18:46,602,223...46,643,870
Ensembl chr18:46,602,284...46,643,865
JBrowse link
G Sp3 Sp3 transcription factor increases expression ISO Phenytoin results in increased expression of SP3 mRNA CTD PMID:14741686 NCBI chr 3:57,811,855...57,857,150
Ensembl chr 3:57,812,075...57,860,342
JBrowse link
G St13 ST13, Hsp70 interacting protein increases expression EXP Phenytoin results in increased expression of ST13 mRNA CTD PMID:17381134 NCBI chr 7:112,891,007...112,925,727 JBrowse link
G Stat4 signal transducer and activator of transcription 4 decreases expression ISO Phenytoin results in decreased expression of STAT4 mRNA CTD PMID:14741686 NCBI chr 9:49,472,660...49,588,540 JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 decreases expression EXP Phenytoin results in decreased expression of SULT1A1 mRNA CTD PMID:9566755 PMID:17381134 NCBI chr 1:181,272,022...181,276,750
Ensembl chr 1:181,272,023...181,275,562
JBrowse link
G Sult2a1 sulfotransferase family 2A member 1 decreases expression EXP Phenytoin results in decreased expression of SULT2A1 mRNA CTD PMID:9566755 NCBI chr 1:75,451,178...75,508,142 JBrowse link
G Syn1 synapsin I multiple interactions
decreases expression
ISO Thyroxine inhibits the reaction [Phenytoin results in decreased expression of SYN1 mRNA] CTD PMID:27413119 NCBI chr  X:1,172,208...1,227,400
Ensembl chr  X:1,172,208...1,227,396
JBrowse link
G Syp synaptophysin multiple interactions
decreases expression
ISO Thyroxine inhibits the reaction [Phenytoin results in decreased expression of SYP mRNA] CTD PMID:27413119 NCBI chr  X:14,849,444...14,864,553
Ensembl chr  X:14,849,444...14,864,745
JBrowse link
G Sypl1 synaptophysin-like 1 increases expression EXP Phenytoin results in increased expression of SYPL mRNA CTD PMID:20345932 NCBI chr 6:49,565,111...49,585,205
Ensembl chr 6:49,565,154...49,585,330
JBrowse link
G Taf9b TATA-box binding protein associated factor 9b increases expression EXP Phenytoin results in increased expression of TAF9B mRNA CTD PMID:20345932 NCBI chr  X:71,289,290...71,300,142
Ensembl chr  X:71,289,290...71,300,604
JBrowse link
G Tbx21 T-box transcription factor 21 multiple interactions
decreases expression
ISO [Phenytoin co-treated with Buthionine Sulfoximine] results in decreased expression of TBX21 mRNA
Phenytoin results in decreased expression of TBX21 mRNA
CTD PMID:23986454 NCBI chr10:82,082,322...82,098,831
Ensembl chr10:82,082,322...82,098,831
JBrowse link
G Tceal1 transcription elongation factor A like 1 increases expression EXP Phenytoin results in increased expression of TCEAL1 mRNA CTD PMID:20345932 NCBI chr  X:100,058,485...100,060,439
Ensembl chr  X:100,058,132...100,060,551
JBrowse link
G Tcf15 transcription factor 15 decreases expression ISO Phenytoin results in decreased expression of TCF15 mRNA CTD PMID:31711903 NCBI chr 3:140,638,984...140,644,766
Ensembl chr 3:140,638,984...140,644,766
JBrowse link
G Terf1 telomeric repeat binding factor 1 increases expression EXP Phenytoin results in increased expression of TERF1 mRNA CTD PMID:20345932 NCBI chr 5:3,443,103...3,472,377
Ensembl chr 5:3,443,106...3,472,340
JBrowse link
G Tgfa transforming growth factor alpha increases expression ISO Phenytoin results in increased expression of TGFA mRNA CTD PMID:9988880 NCBI chr 4:118,618,043...118,700,897
Ensembl chr 4:118,618,269...118,700,894
JBrowse link
G Tgfb1 transforming growth factor, beta 1 increases expression
decreases expression
ISO Phenytoin results in increased expression of TGFB1 mRNA
Phenytoin results in decreased expression of TGFB1 mRNA
CTD PMID:7841657 PMID:9988880 PMID:16141649 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Tgfb2 transforming growth factor, beta 2 decreases expression ISO Phenytoin results in decreased expression of TGFB2 mRNA CTD PMID:9118846 NCBI chr13:98,160,075...98,261,771
Ensembl chr13:98,160,087...98,261,405
JBrowse link
G Tgfb3 transforming growth factor, beta 3 increases expression ISO Phenytoin results in increased expression of TGFB3 mRNA CTD PMID:14741686 NCBI chr 6:105,704,058...105,726,661
Ensembl chr 6:105,704,236...105,726,564
JBrowse link
G Thoc6 THO complex 6 decreases expression EXP Phenytoin results in decreased expression of THOC6 mRNA CTD PMID:20345932 NCBI chr10:12,700,051...12,705,411
Ensembl chr10:12,700,051...12,706,925
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 increases expression ISO Phenytoin results in increased expression of TIMP1 mRNA; Phenytoin results in increased expression of TIMP1 protein CTD PMID:10914799 PMID:14741686 PMID:15948689 NCBI chr  X:1,212,969...1,217,714
Ensembl chr  X:1,212,972...1,217,664
JBrowse link
G Tkt transketolase increases expression EXP Phenytoin results in increased expression of TKT mRNA CTD PMID:17381134 NCBI chr16:5,723,764...5,748,702
Ensembl chr16:5,723,762...5,748,698
JBrowse link
G Tlr2 toll-like receptor 2 multiple interactions
increases expression
ISO [Phenytoin co-treated with Buthionine Sulfoximine] results in increased expression of TLR2 mRNA
Phenytoin results in increased expression of TLR2 mRNA
CTD PMID:23986454 NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630
JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions
decreases expression
ISO [Phenytoin co-treated with Buthionine Sulfoximine] results in decreased expression of TLR4 mRNA
Phenytoin results in decreased expression of TLR4 mRNA
CTD PMID:23986454 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
JBrowse link
G Tlr9 toll-like receptor 9 multiple interactions
decreases expression
ISO [Phenytoin co-treated with Buthionine Sulfoximine] results in decreased expression of TLR9 mRNA
Phenytoin results in decreased expression of TLR9 mRNA
CTD PMID:23986454 NCBI chr 8:106,864,680...106,868,796
Ensembl chr 8:106,864,680...106,868,796
JBrowse link
G Tnf tumor necrosis factor increases expression ISO Phenytoin results in increased expression of TNF mRNA CTD PMID:14741686 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tnfsf10 TNF superfamily member 10 multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of TNFSF10 mRNA CTD PMID:21224054 NCBI chr 2:110,199,835...110,227,239
Ensembl chr 2:110,207,916...110,225,135
JBrowse link
G Tp53 tumor protein p53 increases expression ISO Phenytoin results in increased expression of TP53 mRNA CTD PMID:11134551 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Tp53bp2 tumor protein p53 binding protein, 2 increases expression EXP Phenytoin results in increased expression of TRP53BP2 mRNA CTD PMID:20345932 NCBI chr13:94,088,769...94,145,436
Ensembl chr13:94,088,709...94,145,432
JBrowse link
G Tradd TNFRSF1A-associated via death domain multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of TRADD mRNA CTD PMID:21224054 NCBI chr19:33,136,148...33,142,714
Ensembl chr19:33,136,138...33,142,638
JBrowse link
G Trmt10b tRNA methyltransferase 10B increases expression EXP Phenytoin results in increased expression of TRMT10B mRNA CTD PMID:20345932 NCBI chr 5:59,548,845...59,572,529
Ensembl chr 5:59,548,869...59,572,526
JBrowse link
G Tut4 terminal uridylyl transferase 4 increases expression EXP Phenytoin results in increased expression of TUT4 mRNA CTD PMID:20345932 NCBI chr 5:123,201,723...123,306,582
Ensembl chr 5:123,203,003...123,306,465
JBrowse link
G Txnrd1 thioredoxin reductase 1 increases expression EXP Phenytoin results in increased expression of TXNRD1 mRNA CTD PMID:17381134 NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863
JBrowse link
G Ube2d2 ubiquitin-conjugating enzyme E2D 2 increases expression EXP Phenytoin results in increased expression of UBE2D2 mRNA CTD PMID:20345932 NCBI chr18:27,364,665...27,405,589
Ensembl chr18:27,364,303...27,406,181
JBrowse link
G Ubl5 ubiquitin-like 5 decreases expression EXP Phenytoin results in decreased expression of UBL5 mRNA CTD PMID:20345932 NCBI chr 8:19,183,437...19,185,223
Ensembl chr 8:19,181,615...19,185,217
JBrowse link
G Ubr1 ubiquitin protein ligase E3 component n-recognin 1 increases expression EXP Phenytoin results in increased expression of UBR1 mRNA CTD PMID:20345932 NCBI chr 3:107,813,721...107,921,701
Ensembl chr 3:107,811,392...107,922,204
JBrowse link
G Ugdh UDP-glucose 6-dehydrogenase decreases expression EXP Phenytoin results in decreased expression of UGDH mRNA CTD PMID:17381134 NCBI chr14:42,848,704...42,872,351
Ensembl chr14:42,848,854...42,872,354
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 affects expression
increases activity
multiple interactions
increases expression
ISO
EXP
Phenytoin affects the expression of UGT1A1 mRNA
Phenytoin results in increased activity of UGT1A1 protein
Phenytoin results in increased expression of and results in increased activity of UGT1A1 protein
Phenytoin results in increased expression of UGT1A1 mRNA
Phenytoin results in increased expression of UGT1A1 mRNA; Phenytoin results in increased expression of UGT1A1 protein
CTD PMID:10421657 PMID:15849716 PMID:17381134 PMID:27413119 NCBI chr 9:88,801,344...88,808,465 JBrowse link
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 increases expression EXP Phenytoin results in increased expression of UGT1A6 mRNA CTD PMID:17381134 NCBI chr 9:88,747,229...88,808,465 JBrowse link
G Ugt2b17 UDP glucuronosyltransferase family 2 member B17 increases expression EXP Phenytoin results in increased expression of UGT2B1 mRNA CTD PMID:17381134 NCBI chr14:21,024,035...21,035,784
Ensembl chr14:21,024,006...21,035,986
JBrowse link
G Uncx UNC homeobox decreases expression ISO Phenytoin results in decreased expression of UNCX mRNA CTD PMID:31711903 NCBI chr12:15,092,779...15,097,300
Ensembl chr12:15,092,784...15,097,300
JBrowse link
G Ung uracil-DNA glycosylase multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of UNG mRNA CTD PMID:21224054 NCBI chr12:42,485,276...42,494,217
Ensembl chr12:42,485,276...42,494,206
JBrowse link
G Vars2 valyl-tRNA synthetase 2, mitochondrial increases expression EXP Phenytoin results in increased expression of VARS2 mRNA CTD PMID:20345932 NCBI chr20:3,077,132...3,087,994
Ensembl chr20:3,077,132...3,087,994
JBrowse link
G Vcan versican increases expression ISO Phenytoin results in increased expression of VCAN mRNA CTD PMID:14741686 NCBI chr 2:20,761,718...20,860,637
Ensembl chr 2:20,761,718...20,860,637
JBrowse link
G Vegfb vascular endothelial growth factor B decreases expression ISO Phenytoin results in decreased expression of VEGFB mRNA CTD PMID:14741686 NCBI chr 1:204,172,297...204,178,046
Ensembl chr 1:204,172,225...204,177,944
JBrowse link
G Vim vimentin increases expression ISO Phenytoin results in increased expression of VIM mRNA CTD PMID:14741686 NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187
JBrowse link
G Wnt1 Wnt family member 1 decreases expression ISO Phenytoin results in decreased expression of WNT1 mRNA CTD PMID:7841657 NCBI chr 7:129,938,604...129,942,651
Ensembl chr 7:129,938,604...129,942,651
JBrowse link
G Wnt3 Wnt family member 3 decreases expression ISO Phenytoin results in decreased expression of WNT3 mRNA CTD PMID:26272751 NCBI chr10:88,680,248...88,724,170
Ensembl chr10:88,680,248...88,724,099
JBrowse link
G Wnt5a Wnt family member 5A increases expression ISO Phenytoin results in increased expression of WNT5A mRNA CTD PMID:31711903 NCBI chr16:3,695,667...3,718,234
Ensembl chr16:3,697,032...3,718,234
JBrowse link
G Xrcc4 X-ray repair cross complementing 4 multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of XRCC4 mRNA CTD PMID:21224054 NCBI chr 2:20,948,464...21,197,705
Ensembl chr 2:20,951,200...21,197,808
JBrowse link
G Yme1l1 YME1-like 1 ATPase increases expression EXP Phenytoin results in increased expression of YME1L1 mRNA CTD PMID:20345932 NCBI chr17:85,287,607...85,326,068
Ensembl chr17:85,287,554...85,326,335
JBrowse link
G Zap70 zeta chain of T cell receptor associated protein kinase 70 decreases expression ISO Phenytoin results in decreased expression of ZAP70 mRNA CTD PMID:15136057 NCBI chr 9:38,989,750...39,011,701
Ensembl chr 9:38,989,750...39,011,700
JBrowse link
G Zfp131 zinc finger protein 131 increases expression EXP Phenytoin results in increased expression of ZFP131 mRNA CTD PMID:20345932 NCBI chr 2:51,722,774...51,753,662
Ensembl chr 2:51,725,541...51,753,639
JBrowse link
G Zfp503 zinc finger protein 503 increases expression EXP Phenytoin results in increased expression of ZFP503 mRNA CTD PMID:20345932 NCBI chr15:2,313,060...2,316,848
Ensembl chr15:2,313,060...2,316,848
JBrowse link
G Zfp638 zinc finger protein 638 increases expression EXP Phenytoin results in increased expression of ZFP638 mRNA CTD PMID:20345932 NCBI chr 4:116,355,934...116,479,845
Ensembl chr 4:116,402,428...116,479,845
JBrowse link
G Zscan21 zinc finger and SCAN domain containing 21 increases expression EXP Phenytoin results in increased expression of ZSCAN21 mRNA CTD PMID:20345932 NCBI chr12:16,998,496...17,024,167
Ensembl chr12:16,998,538...17,013,506
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19795
    chemical entity 19795
      atom 19794
        nonmetal atom 19681
          nitrogen atom 18762
            nitrogen molecular entity 18762
              organonitrogen compound 18540
                organonitrogen heterocyclic compound 17659
                  diazolidine 989
                    imidazolidines 979
                      imidazolidinone 613
                        imidazolidine-2,4-dione 478
                          (5R)-5-methylimidazolidine-2,4-dione 0
                          (5S)-5-methylimidazolidine-2,4-dione 0
                          (5S,5aR,8aS,8bR)-7-tert-butyl-5-(4-methoxyphenyl)-8b-methyl-2-(3-methylphenyl)-5a,8a-dihydro-5H-pyrrolo[1,2]pyrrolo[4,5-a]imidazole-1,3,6,8-tetrone 0
                          (S)-Mephenytoin 0
                          1-(hydroxymethyl)-5,5-dimethylhydantoin 0
                          1-Aminohydantoin 0
                          1-[(5-nitro-2-furanyl)methylideneamino]imidazolidine-2,4-dione 0
                          2-(2',5'-dioxo-1'-spiro[3,4-dihydro-2H-1-benzopyran-4,4'-imidazolidine]yl)-N-[4-[ethyl(propan-2-yl)amino]phenyl]acetamide 0
                          2-(2,5-dioxo-4,4-dipropyl-1-imidazolidinyl)-N-(3-methoxyphenyl)acetamide 0
                          2-(2,5-dioxo-4-imidazolidinyl)-N-(1-naphthalenyl)acetamide 0
                          2-(4-butyl-4-methyl-2,5-dioxo-1-imidazolidinyl)-N-[4-(4-morpholinylsulfonyl)phenyl]acetamide 0
                          2-[4-(2-furanylmethylidene)-2,5-dioxo-1-imidazolidinyl]-N-(4-methylphenyl)acetamide 0
                          2-[4-(4-methoxyphenyl)-4-methyl-2,5-dioxo-1-imidazolidinyl]-N-[4-(6-methyl-1,3-benzothiazol-2-yl)phenyl]acetamide 0
                          2-[4-[(1-ethyl-2,5-dimethyl-3-pyrrolyl)methylidene]-2,5-dioxo-1-imidazolidinyl]-N-(3-methylphenyl)acetamide 0
                          2-[4-[(3-ethoxy-4-hydroxyphenyl)methylidene]-2,5-dioxo-1-imidazolidinyl]-N-(3-methylphenyl)acetamide 0
                          2-[4-[4-(difluoromethoxy)phenyl]-4-methyl-2,5-dioxo-1-imidazolidinyl]acetic acid ethyl ester 0
                          2-[[2-(4-ethyl-4-methyl-2,5-dioxo-1-imidazolidinyl)-1-oxoethyl]amino]-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxamide 0
                          3',4'-Dihydrodiol 0
                          3'-HPPH 0
                          3,6,8-Trimethylallantoin 0
                          3-(\{(5R)-3-[3-(1H-imidazol-1-yl)propyl]-5-methyl-5-naphthalen-1-yl-2,4-dioxoimidazolidin-1-yl\}methyl)benzonitrile 0
                          3-[(2-fluorophenyl)methyl]-5-(1H-indol-3-ylmethylidene)imidazolidine-2,4-dione 0
                          3-[(2-fluorophenyl)methyl]-5-[(5-methyl-2-furanyl)methylidene]imidazolidine-2,4-dione 0
                          3-[(4S)-2,5-dioxoimidazolidin-4-yl]propanoic acid 0
                          3-[2-[4-(4-chlorophenyl)sulfonyl-1-piperazinyl]-2-oxoethyl]-5-(2-methylpropyl)imidazolidine-2,4-dione 0
                          3-[2-[[1-(3-chlorophenyl)-2,5-dioxo-4-imidazolidinylidene]methyl]-1-pyrrolyl]benzoic acid 0
                          3-[2-hydroxy-3-(4-morpholinyl)propyl]-5,5-dimethylimidazolidine-2,4-dione 0
                          4-[(2,4-dioxo-1,3-diazaspiro[4.5]decan-3-yl)methyl]benzoic acid methyl ester 0
                          4-[2-[(2,5-dioxo-1-phenyl-4-imidazolidinylidene)methyl]-1-pyrrolyl]benzoic acid 0
                          4-[5-[[1-[(2-chlorophenyl)methyl]-2,5-dioxo-4-imidazolidinylidene]methyl]-2-furanyl]-3-methylbenzoic acid 0
                          4-[[2-ethoxy-4-[(1-ethyl-2,5-dioxo-4-imidazolidinylidene)methyl]-6-prop-2-enylphenoxy]methyl]benzoic acid 0
                          4-hydroxyphenytoin 5
                          5,5-Dimethylhydantoin 0
                          5-(2-furanylmethylidene)imidazolidine-2,4-dione 0
                          5-(3,4-Dihydroxy-1,5-cyclohexadien-1-yl)-5-phenylhydantoin 0
                          5-(4-hydroxybutyl)hydantoin 0
                          5-Hydroxydantrolene 0
                          5-[(1-ethyl-2,5-dimethyl-3-pyrrolyl)methylidene]-3-phenylimidazolidine-2,4-dione 0
                          5-[(2,4,5-trihydroxyphenyl)methyl]imidazolidine-2,4-dione 0
                          5-[[2,5-dimethyl-1-(3-pyridinyl)-3-pyrrolyl]methylidene]-3-phenylimidazolidine-2,4-dione 0
                          5-guanidinohydantoin 0
                          5-methyl-3-[2-(4-morpholinyl)-2-oxoethyl]-5-phenylimidazolidine-2,4-dione 0
                          5-methylimidazolidine-2,4-dione 0
                          7-[3-(3-cyclohexyl-3-hydroxypropyl)-2,5-dioxoimidazolidin-4-yl]heptanoic acid + 2
                          Alloxanoic acid 4tms NIST 0
                          Aminofurantoin 0
                          Azimilide 1
                          D-5-monosubstituted hydantoin + 0
                          Fosphenytoin 0
                          Hydroxymephenytoin 1
                          Idanpramine 0
                          L-5-benzyl-hydantoin 0
                          L-5-carboxymethylhydantoin 0
                          L-5-monosubstituted hydantoin + 0
                          N-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-[4-methyl-2,5-dioxo-4-(2-phenylethyl)-1-imidazolidinyl]acetamide 0
                          N-(3-cyanophenyl)-2-(4-ethyl-2,5-dioxo-4-phenyl-1-imidazolidinyl)acetamide 0
                          N-(3-methylphenyl)-2-[4-[(5-methyl-2-thiophenyl)methylidene]-2,5-dioxo-1-imidazolidinyl]acetamide 0
                          N-(4-ethoxyphenyl)-2-[4-[2-(methylthio)ethyl]-2,5-dioxo-1-imidazolidinyl]acetamide 0
                          N-(4-methylphenyl)-2-[4-[(5-methyl-2-thiophenyl)methylidene]-2,5-dioxo-1-imidazolidinyl]acetamide 0
                          N-[3-(1-azepanylsulfonyl)phenyl]-2-[4-(1H-indol-3-ylmethyl)-2,5-dioxo-1-imidazolidinyl]acetamide 0
                          N-[4-(6-methyl-1,3-benzothiazol-2-yl)phenyl]-2-[4-methyl-4-(4-methylphenyl)-2,5-dioxo-1-imidazolidinyl]acetamide 0
                          N-methylhydantoin 0
                          Nirvanol 0
                          Phenytoin arene-oxide 0
                          Phenytoin methylcatechol 0
                          RO4927350 0
                          S-nirvanol 0
                          allantoin + 10
                          amino(diphenylhydantoin) valeric acid 0
                          azumolene 0
                          clodantoin 0
                          dantrolene 53
                          diazolidinylurea 0
                          ethotoin + 1
                          furagin 0
                          hydantoin + 413
                          hydantoin-5-propionic acid 0
                          iprodione 32
                          mephenytoin 8
                          nifurfoline 0
                          nifurtoinol 0
                          nitrofurantoin 25
                          p-Hydroxyl-ethotoin 0
                          phenytoin 407
                          phethenylate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19795
    subatomic particle 19794
      composite particle 19794
        hadron 19794
          baryon 19794
            nucleon 19794
              atomic nucleus 19794
                atom 19794
                  main group element atom 19693
                    p-block element atom 19693
                      carbon group element atom 19614
                        carbon atom 19604
                          organic molecular entity 19604
                            organic molecule 19545
                              organic cyclic compound 19339
                                organic heterocyclic compound 18579
                                  organic heteromonocyclic compound 17121
                                    diazolidine 989
                                      imidazolidines 979
                                        imidazolidinone 613
                                          imidazolidine-2,4-dione 478
                                            (5R)-5-methylimidazolidine-2,4-dione 0
                                            (5S)-5-methylimidazolidine-2,4-dione 0
                                            (5S,5aR,8aS,8bR)-7-tert-butyl-5-(4-methoxyphenyl)-8b-methyl-2-(3-methylphenyl)-5a,8a-dihydro-5H-pyrrolo[1,2]pyrrolo[4,5-a]imidazole-1,3,6,8-tetrone 0
                                            (S)-Mephenytoin 0
                                            1-(hydroxymethyl)-5,5-dimethylhydantoin 0
                                            1-Aminohydantoin 0
                                            1-[(5-nitro-2-furanyl)methylideneamino]imidazolidine-2,4-dione 0
                                            2-(2',5'-dioxo-1'-spiro[3,4-dihydro-2H-1-benzopyran-4,4'-imidazolidine]yl)-N-[4-[ethyl(propan-2-yl)amino]phenyl]acetamide 0
                                            2-(2,5-dioxo-4,4-dipropyl-1-imidazolidinyl)-N-(3-methoxyphenyl)acetamide 0
                                            2-(2,5-dioxo-4-imidazolidinyl)-N-(1-naphthalenyl)acetamide 0
                                            2-(4-butyl-4-methyl-2,5-dioxo-1-imidazolidinyl)-N-[4-(4-morpholinylsulfonyl)phenyl]acetamide 0
                                            2-[4-(2-furanylmethylidene)-2,5-dioxo-1-imidazolidinyl]-N-(4-methylphenyl)acetamide 0
                                            2-[4-(4-methoxyphenyl)-4-methyl-2,5-dioxo-1-imidazolidinyl]-N-[4-(6-methyl-1,3-benzothiazol-2-yl)phenyl]acetamide 0
                                            2-[4-[(1-ethyl-2,5-dimethyl-3-pyrrolyl)methylidene]-2,5-dioxo-1-imidazolidinyl]-N-(3-methylphenyl)acetamide 0
                                            2-[4-[(3-ethoxy-4-hydroxyphenyl)methylidene]-2,5-dioxo-1-imidazolidinyl]-N-(3-methylphenyl)acetamide 0
                                            2-[4-[4-(difluoromethoxy)phenyl]-4-methyl-2,5-dioxo-1-imidazolidinyl]acetic acid ethyl ester 0
                                            2-[[2-(4-ethyl-4-methyl-2,5-dioxo-1-imidazolidinyl)-1-oxoethyl]amino]-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxamide 0
                                            3',4'-Dihydrodiol 0
                                            3'-HPPH 0
                                            3,6,8-Trimethylallantoin 0
                                            3-(\{(5R)-3-[3-(1H-imidazol-1-yl)propyl]-5-methyl-5-naphthalen-1-yl-2,4-dioxoimidazolidin-1-yl\}methyl)benzonitrile 0
                                            3-[(2-fluorophenyl)methyl]-5-(1H-indol-3-ylmethylidene)imidazolidine-2,4-dione 0
                                            3-[(2-fluorophenyl)methyl]-5-[(5-methyl-2-furanyl)methylidene]imidazolidine-2,4-dione 0
                                            3-[(4S)-2,5-dioxoimidazolidin-4-yl]propanoic acid 0
                                            3-[2-[4-(4-chlorophenyl)sulfonyl-1-piperazinyl]-2-oxoethyl]-5-(2-methylpropyl)imidazolidine-2,4-dione 0
                                            3-[2-[[1-(3-chlorophenyl)-2,5-dioxo-4-imidazolidinylidene]methyl]-1-pyrrolyl]benzoic acid 0
                                            3-[2-hydroxy-3-(4-morpholinyl)propyl]-5,5-dimethylimidazolidine-2,4-dione 0
                                            4-[(2,4-dioxo-1,3-diazaspiro[4.5]decan-3-yl)methyl]benzoic acid methyl ester 0
                                            4-[2-[(2,5-dioxo-1-phenyl-4-imidazolidinylidene)methyl]-1-pyrrolyl]benzoic acid 0
                                            4-[5-[[1-[(2-chlorophenyl)methyl]-2,5-dioxo-4-imidazolidinylidene]methyl]-2-furanyl]-3-methylbenzoic acid 0
                                            4-[[2-ethoxy-4-[(1-ethyl-2,5-dioxo-4-imidazolidinylidene)methyl]-6-prop-2-enylphenoxy]methyl]benzoic acid 0
                                            4-hydroxyphenytoin 5
                                            5,5-Dimethylhydantoin 0
                                            5-(2-furanylmethylidene)imidazolidine-2,4-dione 0
                                            5-(3,4-Dihydroxy-1,5-cyclohexadien-1-yl)-5-phenylhydantoin 0
                                            5-(4-hydroxybutyl)hydantoin 0
                                            5-Hydroxydantrolene 0
                                            5-[(1-ethyl-2,5-dimethyl-3-pyrrolyl)methylidene]-3-phenylimidazolidine-2,4-dione 0
                                            5-[(2,4,5-trihydroxyphenyl)methyl]imidazolidine-2,4-dione 0
                                            5-[[2,5-dimethyl-1-(3-pyridinyl)-3-pyrrolyl]methylidene]-3-phenylimidazolidine-2,4-dione 0
                                            5-guanidinohydantoin 0
                                            5-methyl-3-[2-(4-morpholinyl)-2-oxoethyl]-5-phenylimidazolidine-2,4-dione 0
                                            5-methylimidazolidine-2,4-dione 0
                                            7-[3-(3-cyclohexyl-3-hydroxypropyl)-2,5-dioxoimidazolidin-4-yl]heptanoic acid + 2
                                            Alloxanoic acid 4tms NIST 0
                                            Aminofurantoin 0
                                            Azimilide 1
                                            D-5-monosubstituted hydantoin + 0
                                            Fosphenytoin 0
                                            Hydroxymephenytoin 1
                                            Idanpramine 0
                                            L-5-benzyl-hydantoin 0
                                            L-5-carboxymethylhydantoin 0
                                            L-5-monosubstituted hydantoin + 0
                                            N-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-[4-methyl-2,5-dioxo-4-(2-phenylethyl)-1-imidazolidinyl]acetamide 0
                                            N-(3-cyanophenyl)-2-(4-ethyl-2,5-dioxo-4-phenyl-1-imidazolidinyl)acetamide 0
                                            N-(3-methylphenyl)-2-[4-[(5-methyl-2-thiophenyl)methylidene]-2,5-dioxo-1-imidazolidinyl]acetamide 0
                                            N-(4-ethoxyphenyl)-2-[4-[2-(methylthio)ethyl]-2,5-dioxo-1-imidazolidinyl]acetamide 0
                                            N-(4-methylphenyl)-2-[4-[(5-methyl-2-thiophenyl)methylidene]-2,5-dioxo-1-imidazolidinyl]acetamide 0
                                            N-[3-(1-azepanylsulfonyl)phenyl]-2-[4-(1H-indol-3-ylmethyl)-2,5-dioxo-1-imidazolidinyl]acetamide 0
                                            N-[4-(6-methyl-1,3-benzothiazol-2-yl)phenyl]-2-[4-methyl-4-(4-methylphenyl)-2,5-dioxo-1-imidazolidinyl]acetamide 0
                                            N-methylhydantoin 0
                                            Nirvanol 0
                                            Phenytoin arene-oxide 0
                                            Phenytoin methylcatechol 0
                                            RO4927350 0
                                            S-nirvanol 0
                                            allantoin + 10
                                            amino(diphenylhydantoin) valeric acid 0
                                            azumolene 0
                                            clodantoin 0
                                            dantrolene 53
                                            diazolidinylurea 0
                                            ethotoin + 1
                                            furagin 0
                                            hydantoin + 413
                                            hydantoin-5-propionic acid 0
                                            iprodione 32
                                            mephenytoin 8
                                            nifurfoline 0
                                            nifurtoinol 0
                                            nitrofurantoin 25
                                            p-Hydroxyl-ethotoin 0
                                            phenytoin 407
                                            phethenylate 0
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