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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:homocysteines
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Accession:CHEBI:24610 term browser browse the term


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homocysteic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha multiple interactions EXP [homocysteic acid co-treated with GW 506033X] results in increased phosphorylation of EIF2S1 protein CTD PMID:19046382 NCBI chr 6:102,048,372...102,073,041
Ensembl chr 6:102,048,372...102,073,041
JBrowse link
G Hsf1 heat shock transcription factor 1 decreases expression EXP homocysteic acid results in decreased expression of HSF1 protein CTD PMID:24478344 NCBI chr 7:117,538,523...117,565,478
Ensembl chr 7:117,538,523...117,565,478
JBrowse link
G Sp1 Sp1 transcription factor increases activity
multiple interactions
ISO homocysteic acid results in increased activity of SP1 protein
mithramycin A inhibits the reaction [homocysteic acid results in increased activity of SP1 protein]
CTD PMID:11261509 NCBI chr 7:144,014,173...144,044,635
Ensembl chr 7:144,014,173...144,044,629
JBrowse link
G Sp3 Sp3 transcription factor multiple interactions
increases activity
ISO mithramycin A inhibits the reaction [homocysteic acid results in increased activity of SP3 protein] CTD PMID:11261509 NCBI chr 3:59,644,579...59,689,011
Ensembl chr 3:59,646,015...59,688,692
JBrowse link
homocysteine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acadm acyl-CoA dehydrogenase medium chain increases expression ISO Homocysteine results in increased expression of ACADM mRNA; Homocysteine results in increased expression of ACADM protein CTD PMID:26993217 NCBI chr 2:260,124,418...260,148,589
Ensembl chr 2:260,124,418...260,148,589
JBrowse link
G Ache acetylcholinesterase increases activity ISO Homocysteine results in increased activity of ACHE protein CTD PMID:16375580 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions
increases expression
ISO [Folic Acid deficiency results in increased abundance of Homocysteine] which results in increased expression of ACTA2 mRNA; [Folic Acid deficiency results in increased abundance of Homocysteine] which results in increased expression of ACTA2 protein; CYBB mutant form inhibits the reaction [[Folic Acid deficiency results in increased abundance of Homocysteine] which results in increased expression of ACTA2 mRNA]; CYBB mutant form inhibits the reaction [[Folic Acid deficiency results in increased abundance of Homocysteine] which results in increased expression of ACTA2 protein]
Homocysteine results in increased expression of ACTA2 mRNA; Homocysteine results in increased expression of ACTA2 protein
CTD PMID:21647593 NCBI chr 1:252,537,614...252,550,394
Ensembl chr 1:252,537,615...252,550,394
JBrowse link
G Ahcy adenosylhomocysteinase multiple interactions ISO [Arsenic results in increased expression of and results in increased activity of AHCY protein] which results in increased chemical synthesis of Homocysteine CTD PMID:18487201 NCBI chr 3:150,587,833...150,603,057
Ensembl chr 3:150,587,833...150,603,082
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
decreases phosphorylation
ISO Atorvastatin inhibits the reaction [Homocysteine results in decreased phosphorylation of AKT1 protein] CTD PMID:20305681 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Apoa1 apolipoprotein A1 decreases expression
multiple interactions
ISO Homocysteine results in decreased expression of APOA1 mRNA; Homocysteine results in decreased expression of APOA1 protein
Homocysteine inhibits the reaction [Simvastatin results in increased expression of APOA1 mRNA]; Homocysteine inhibits the reaction [Simvastatin results in increased expression of APOA1 protein]
CTD PMID:18540024 NCBI chr 8:50,525,091...50,526,875
Ensembl chr 8:50,525,091...50,526,875
JBrowse link
G App amyloid beta precursor protein increases abundance ISO APP protein results in increased abundance of Homocysteine CTD PMID:16837103 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
JBrowse link
G Atf1 activating transcription factor 1 multiple interactions EXP Homocysteine promotes the reaction [ATF1 protein binds to CCNA2 promoter] CTD PMID:8550827 NCBI chr 7:141,882,261...141,924,790
Ensembl chr 7:141,882,251...141,924,788
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression
affects expression
ISO
EXP
Folic Acid affects the reaction [Homocysteine affects the expression of BAX mRNA]; Folic Acid affects the reaction [Homocysteine affects the expression of BAX protein]; Zeranol inhibits the reaction [Homocysteine results in increased expression of BAX protein]
Homocysteine results in increased expression of BAX mRNA
Folic Acid inhibits the reaction [Homocysteine results in increased expression of BAX mRNA]
Homocysteine affects the expression of BAX mRNA; Homocysteine affects the expression of BAX protein
CTD PMID:16757814 PMID:29250709 PMID:31721048 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bche butyrylcholinesterase multiple interactions
decreases activity
EXP Folic Acid inhibits the reaction [Homocysteine results in decreased activity of BCHE protein] CTD PMID:16442260 NCBI chr 2:171,104,476...171,196,186
Ensembl chr 2:171,100,140...171,196,395
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
affects expression
decreases expression
ISO
EXP
Folic Acid affects the reaction [Homocysteine affects the expression of BCL2 mRNA]; Folic Acid affects the reaction [Homocysteine affects the expression of BCL2 protein]; Zeranol inhibits the reaction [Homocysteine results in decreased expression of BCL2 protein]
Homocysteine affects the expression of BCL2 mRNA; Homocysteine affects the expression of BCL2 protein
[Homocysteine co-treated with Sodium Glutamate] affects the expression of BCL2 mRNA; [Homocysteine co-treated with Sodium Glutamate] affects the expression of BCL2 protein; Folic Acid affects the reaction [[Homocysteine co-treated with Sodium Glutamate] affects the expression of BCL2 mRNA]; Folic Acid affects the reaction [[Homocysteine co-treated with Sodium Glutamate] affects the expression of BCL2 protein]
CTD PMID:16757814 PMID:22169520 PMID:29250709 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Birc2 baculoviral IAP repeat-containing 2 decreases expression
multiple interactions
ISO Homocysteine results in decreased expression of BIRC2 mRNA; Homocysteine results in decreased expression of BIRC2 protein
Simvastatin inhibits the reaction [Homocysteine results in decreased expression of BIRC2 mRNA]; Simvastatin inhibits the reaction [Homocysteine results in decreased expression of BIRC2 protein]
CTD PMID:19343037 NCBI chr 8:6,014,014...6,036,668
Ensembl chr 8:6,013,207...6,034,142
JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 decreases expression
multiple interactions
ISO Homocysteine results in decreased expression of BIRC3 mRNA; Homocysteine results in decreased expression of BIRC3 protein
Simvastatin inhibits the reaction [Homocysteine results in decreased expression of BIRC3 mRNA]; Simvastatin inhibits the reaction [Homocysteine results in decreased expression of BIRC3 protein]
CTD PMID:19343037 NCBI chr 8:6,048,590...6,076,828
Ensembl chr 8:6,048,969...6,076,598
JBrowse link
G Cacna2d1 calcium voltage-gated channel auxiliary subunit alpha2delta 1 affects binding EXP Homocysteine analog binds to CACNA2D1 protein CTD PMID:16380257 NCBI chr 4:15,706,974...16,130,848
Ensembl chr 4:15,710,417...16,130,848
JBrowse link
G Calr calreticulin increases expression ISO Homocysteine results in increased expression of CALR mRNA CTD PMID:26993217 NCBI chr19:25,956,771...25,961,666
Ensembl chr19:25,956,771...25,961,666
JBrowse link
G Casp1 caspase 1 multiple interactions
increases activity
increases expression
ISO [Folic Acid deficiency results in increased abundance of Homocysteine] promotes the reaction [NLRC3 protein binds to PYCARD protein binds to CASP1 protein]; CASP1 protein affects the reaction [Homocysteine promotes the reaction [NLRC3 protein binds to PYCARD protein binds to CASP1 protein]]; CASP1 protein affects the reaction [Homocysteine results in decreased secretion of VEGFA protein]; Homocysteine promotes the reaction [NLRC3 protein binds to PYCARD protein binds to CASP1 protein]; PYCARD protein affects the reaction [Homocysteine promotes the reaction [NLRC3 protein binds to PYCARD protein binds to CASP1 protein]]; PYCARD protein affects the reaction [Homocysteine results in increased activity of CASP1 protein]
Homocysteine results in increased expression of CASP1 mRNA
CTD PMID:22647887 NCBI chr 8:2,605,743...2,614,637
Ensembl chr 8:2,604,962...2,614,631
JBrowse link
G Casp3 caspase 3 multiple interactions
affects expression
increases expression
affects cleavage
increases activity
ISO
EXP
Folic Acid affects the reaction [Homocysteine affects the cleavage of CASP3 protein]; Folic Acid affects the reaction [Homocysteine affects the expression of CASP3 mRNA]; mecobalamin inhibits the reaction [Homocysteine results in increased activity of CASP3 protein]; Simvastatin inhibits the reaction [Homocysteine results in increased activity of CASP3 protein]
Homocysteine results in increased expression of CASP3 protein
Folic Acid inhibits the reaction [Homocysteine results in increased expression of CASP3 protein]
Atorvastatin inhibits the reaction [Homocysteine results in increased activity of CASP3 protein]
Homocysteine results in increased expression of CASP3 mRNA; Homocysteine results in increased expression of CASP3 protein
CTD PMID:16715183 PMID:19343037 PMID:20305681 PMID:21237187 PMID:29250709 PMID:31721048 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp7 caspase 7 increases activity
multiple interactions
ISO Homocysteine results in increased activity of CASP7 protein
mecobalamin inhibits the reaction [Homocysteine results in increased activity of CASP7 protein]
CTD PMID:21237187 NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774
JBrowse link
G Casp8 caspase 8 multiple interactions
affects expression
ISO Folic Acid affects the reaction [Homocysteine affects the expression of CASP8 mRNA]; Folic Acid affects the reaction [Homocysteine affects the expression of CASP8 protein]
Homocysteine affects the expression of CASP8 mRNA; Homocysteine affects the expression of CASP8 protein
CTD PMID:29250709 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Cat catalase decreases transport
multiple interactions
decreases expression
ISO CAT protein results in decreased transport of Homocysteine
[CAT gene SNP results in increased susceptibility to [Air Pollutants results in increased abundance of Particulate Matter]] which results in increased abundance of Homocysteine
Homocysteine results in decreased expression of CAT protein
CTD PMID:12631446 PMID:22964297 PMID:30477822 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Cbs cystathionine beta synthase affects abundance
multiple interactions
ISO
EXP
CBS protein affects the abundance of Homocysteine; CBS protein affects the abundance of Homocysteine metabolite
Homocysteine inhibits the reaction [Folic Acid results in increased activity of CBS protein]
CTD PMID:19204075 PMID:23024785 PMID:31721048 NCBI chr20:10,361,987...10,386,663
Ensembl chr20:10,361,988...10,386,751
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions
increases expression
ISO [Homocysteine results in increased expression of CCL2 protein] which results in increased phosphorylation of NFKBIA protein; [Homocysteine results in increased expression of CCL2 protein] which results in increased reduction of NFKBIA mRNA; acetovanillone inhibits the reaction [Homocysteine results in increased expression of CCL2 mRNA]; Folic Acid inhibits the reaction [Homocysteine results in increased expression of CCL2 mRNA]
Homocysteine results in increased expression of CCL2 mRNA; Homocysteine results in increased expression of CCL2 protein
CTD PMID:11356643 PMID:16845898 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions
increases expression
ISO [Homocysteine co-treated with Lipopolysaccharides] results in increased secretion of CCL5 protein
Homocysteine results in increased expression of CCL5 mRNA
CTD PMID:16225753 NCBI chr10:70,739,764...70,744,303
Ensembl chr10:70,739,800...70,744,315
JBrowse link
G Ccn4 cellular communication network factor 4 decreases expression ISO Homocysteine results in decreased expression of CCN4 mRNA CTD PMID:17320366 NCBI chr 7:107,695,227...107,723,759
Ensembl chr 7:107,695,215...107,723,772
JBrowse link
G Ccna1 cyclin A1 multiple interactions
decreases methylation
decreases expression
ISO DNMT1 protein affects the reaction [Homocysteine results in decreased expression of CCNA1 mRNA]; Homocysteine inhibits the reaction [MECP2 protein binds to CCNA1 promoter]; Homocysteine promotes the reaction [H3-4 protein modified form binds to CCNA1 promoter]; Homocysteine promotes the reaction [H4-16 protein modified form binds to CCNA1 promoter]
Homocysteine results in decreased methylation of CCNA1 promoter
CTD PMID:17698632 NCBI chr 2:144,456,689...144,503,570
Ensembl chr 2:144,458,153...144,467,912
JBrowse link
G Ccna2 cyclin A2 multiple interactions
increases expression
EXP Dactinomycin inhibits the reaction [Homocysteine results in increased expression of CCNA2 mRNA]; Homocysteine promotes the reaction [ATF1 protein binds to CCNA2 promoter]
Homocysteine results in increased expression of CCNA2 mRNA; Homocysteine results in increased expression of CCNA2 protein
CTD PMID:8550827 NCBI chr 2:123,274,727...123,282,266
Ensembl chr 2:123,275,881...123,282,214
JBrowse link
G Cdh3 cadherin 3 multiple interactions
decreases expression
ISO [Folic Acid deficiency results in increased abundance of Homocysteine] which results in decreased expression of CDH3 mRNA; [Folic Acid deficiency results in increased abundance of Homocysteine] which results in decreased expression of CDH3 protein; acetovanillone inhibits the reaction [Homocysteine results in decreased expression of CDH3 protein]; CYBB mutant form inhibits the reaction [[Folic Acid deficiency results in increased abundance of Homocysteine] which results in decreased expression of CDH3 mRNA]; CYBB mutant form inhibits the reaction [[Folic Acid deficiency results in increased abundance of Homocysteine] which results in decreased expression of CDH3 protein]; CYBB mutant form inhibits the reaction [Homocysteine results in decreased expression of CDH3 protein]
Homocysteine results in decreased expression of CDH3 mRNA; Homocysteine results in decreased expression of CDH3 protein
CTD PMID:21647593 NCBI chr19:38,668,957...38,719,801
Ensembl chr19:38,669,230...38,719,677
JBrowse link
G Comt catechol-O-methyltransferase multiple interactions ISO [tolcapone results in decreased activity of COMT protein] inhibits the reaction [Levodopa results in increased abundance of Homocysteine] CTD PMID:16758261 NCBI chr11:86,715,981...86,735,630
Ensembl chr11:86,715,981...86,735,622
JBrowse link
G Cox5b cytochrome c oxidase subunit 5B multiple interactions ISO [Methionine deficiency co-treated with Homocysteine] affects the expression of COX5B protein CTD PMID:17116298 NCBI chr 9:43,259,706...43,262,039
Ensembl chr 9:43,259,709...43,262,040
JBrowse link
G Crk CRK proto-oncogene, adaptor protein multiple interactions ISO [Methionine deficiency co-treated with Homocysteine] affects the expression of CRK protein CTD PMID:17116298 NCBI chr10:63,829,731...63,855,999
Ensembl chr10:63,829,807...63,852,780
JBrowse link
G Cybb cytochrome b-245 beta chain multiple interactions
increases expression
affects localization
ISO CYBB mutant form inhibits the reaction [[Folic Acid deficiency results in increased abundance of Homocysteine] which results in decreased expression of CDH3 mRNA]; CYBB mutant form inhibits the reaction [[Folic Acid deficiency results in increased abundance of Homocysteine] which results in decreased expression of CDH3 protein]; CYBB mutant form inhibits the reaction [[Folic Acid deficiency results in increased abundance of Homocysteine] which results in decreased expression of TJP1 mRNA]; CYBB mutant form inhibits the reaction [[Folic Acid deficiency results in increased abundance of Homocysteine] which results in increased expression of ACTA2 mRNA]; CYBB mutant form inhibits the reaction [[Folic Acid deficiency results in increased abundance of Homocysteine] which results in increased expression of ACTA2 protein]; CYBB mutant form inhibits the reaction [[Folic Acid deficiency results in increased abundance of Homocysteine] which results in increased expression of S100A4 mRNA]; CYBB mutant form inhibits the reaction [[Folic Acid deficiency results in increased abundance of Homocysteine] which results in increased expression of S100A4 protein]; CYBB mutant form inhibits the reaction [Homocysteine results in decreased expression of CDH3 protein]; CYBB mutant form inhibits the reaction [Homocysteine results in decreased expression of TJP1 protein]; CYBB mutant form inhibits the reaction [Homocysteine results in increased abundance of Superoxides]; CYBB mutant form inhibits the reaction [Homocysteine results in increased expression of S100A4 protein]; CYBB protein affects the reaction [Homocysteine results in decreased secretion of VEGFA protein]; CYBB protein affects the reaction [Homocysteine results in increased abundance of Superoxides]; CYBB protein mutant form inhibits the reaction [[Folic Acid deficiency results in increased abundance of Homocysteine] which results in decreased expression of NPHS1 mRNA]; CYBB protein mutant form inhibits the reaction [[Folic Acid deficiency results in increased abundance of Homocysteine] which results in decreased expression of NPHS2 mRNA]; CYBB protein mutant form inhibits the reaction [[Folic Acid deficiency results in increased abundance of Homocysteine] which results in increased expression of DES mRNA]; Filipin inhibits the reaction [Homocysteine affects the localization of CYBB protein]; methyl-beta-cyclodextrin inhibits the reaction [Homocysteine affects the localization of CYBB protein]
Homocysteine results in increased expression of CYBB mRNA; Homocysteine results in increased expression of CYBB protein
CTD PMID:20036696 PMID:20116427 PMID:21647593 NCBI chr  X:14,578,330...14,610,049
Ensembl chr  X:14,578,264...14,612,547
JBrowse link
G Ddc dopa decarboxylase multiple interactions ISO [Levodopa co-treated with DDC] results in decreased abundance of Homocysteine CTD PMID:11445284 NCBI chr14:91,905,919...91,996,816
Ensembl chr14:91,905,919...91,996,774
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions
increases expression
ISO Glycine inhibits the reaction [Homocysteine results in increased expression of DDIT3 mRNA]; Glycine inhibits the reaction [Homocysteine results in increased expression of DDIT3 protein]
Homocysteine results in increased expression of DDIT3 mRNA; Homocysteine results in increased expression of DDIT3 protein
CTD PMID:27064126 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
JBrowse link
G Des desmin multiple interactions
increases expression
ISO [Folic Acid deficiency results in increased abundance of Homocysteine] which results in increased expression of DES mRNA; acetovanillone inhibits the reaction [Homocysteine results in increased expression of DES mRNA]; acetovanillone inhibits the reaction [Homocysteine results in increased expression of DES protein]; Amitriptyline inhibits the reaction [Homocysteine results in increased expression of DES protein]; CYBB protein mutant form inhibits the reaction [[Folic Acid deficiency results in increased abundance of Homocysteine] which results in increased expression of DES mRNA]; diphenyleneiodonium inhibits the reaction [Homocysteine results in increased expression of DES mRNA]; diphenyleneiodonium inhibits the reaction [Homocysteine results in increased expression of DES protein]; Filipin inhibits the reaction [Homocysteine results in increased expression of DES mRNA]; Filipin inhibits the reaction [Homocysteine results in increased expression of DES protein]; methyl-beta-cyclodextrin inhibits the reaction [Homocysteine results in increased expression of DES mRNA]; methyl-beta-cyclodextrin inhibits the reaction [Homocysteine results in increased expression of DES protein]
Homocysteine results in increased expression of DES mRNA; Homocysteine results in increased expression of DES protein
CTD PMID:20036696 PMID:20116427 PMID:23024785 NCBI chr 9:82,556,574...82,564,288
Ensembl chr 9:82,556,573...82,564,294
JBrowse link
G Dnmt1 DNA methyltransferase 1 decreases activity
multiple interactions
ISO Homocysteine results in decreased activity of DNMT1 protein
DNMT1 protein affects the reaction [Homocysteine results in decreased expression of CCNA1 mRNA]
CTD PMID:17698632 NCBI chr 8:21,922,515...21,968,495
Ensembl chr 8:21,922,515...21,968,495
JBrowse link
G Edn1 endothelin 1 multiple interactions
affects expression
ISO Zeranol inhibits the reaction [Homocysteine affects the expression of EDN1 protein] CTD PMID:16757814 NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324
JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 decreases phosphorylation ISO Homocysteine results in decreased phosphorylation of EIF2AK3 protein CTD PMID:22964297 NCBI chr 4:98,648,513...98,709,695
Ensembl chr 4:98,648,545...98,709,694
JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha increases phosphorylation ISO Homocysteine results in increased phosphorylation of EIF2S1 protein CTD PMID:22964297 NCBI chr 6:102,048,372...102,073,041
Ensembl chr 6:102,048,372...102,073,041
JBrowse link
G Ephb6 Eph receptor B6 decreases expression ISO Homocysteine results in decreased expression of EPHB6 mRNA CTD PMID:17320366 NCBI chr 4:70,903,253...70,918,514
Ensembl chr 4:70,903,253...70,918,514
JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 decreases phosphorylation ISO Homocysteine results in decreased phosphorylation of ERN1 protein CTD PMID:22964297 NCBI chr10:94,588,555...94,682,072
Ensembl chr10:94,588,555...94,681,914
JBrowse link
G Ero1a endoplasmic reticulum oxidoreductase 1 alpha decreases expression ISO Homocysteine results in decreased expression of ERO1A protein CTD PMID:22964297 NCBI chr15:19,619,947...19,655,381
Ensembl chr15:19,619,973...19,655,381
JBrowse link
G Exosc4 exosome component 4 multiple interactions ISO [Methionine deficiency co-treated with Homocysteine] affects the expression of EXOSC4 protein CTD PMID:17116298 NCBI chr 7:117,390,302...117,393,044
Ensembl chr 7:117,390,285...117,393,719
JBrowse link
G Gata4 GATA binding protein 4 decreases expression
multiple interactions
EXP Homocysteine results in decreased expression of GATA4 mRNA; Homocysteine results in decreased expression of GATA4 protein
Particulate Matter promotes the reaction [Homocysteine results in decreased expression of GATA4 protein]
CTD PMID:27203204 NCBI chr15:46,386,703...46,458,679
Ensembl chr15:46,386,712...46,432,965
JBrowse link
G Gh1 growth hormone 1 decreases abundance ISO GH1 protein results in decreased abundance of Homocysteine CTD PMID:17311540 PMID:17324600 NCBI chr10:94,486,204...94,488,181
Ensembl chr10:94,486,205...94,488,180
JBrowse link
G Gpx1 glutathione peroxidase 1 decreases activity
decreases expression
ISO Homocysteine results in decreased activity of GPX1 protein
Homocysteine results in decreased expression of GPX1 protein
CTD PMID:15734734 NCBI chr 8:117,117,430...117,118,528
Ensembl chr 8:117,117,430...117,118,522
JBrowse link
G Grin1 glutamate ionotropic receptor NMDA type subunit 1 increases expression EXP Homocysteine analog results in increased expression of GRIN1 protein CTD PMID:20406136 NCBI chr 3:2,507,745...2,534,664
Ensembl chr 3:2,506,896...2,534,663
JBrowse link
G Gsr glutathione-disulfide reductase decreases expression ISO Homocysteine results in decreased expression of GSR protein CTD PMID:22964297 NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361
JBrowse link
G Gstm3 glutathione S-transferase mu 3 multiple interactions ISO [Methionine deficiency co-treated with Homocysteine] affects the expression of GSTM3 protein CTD PMID:17116298 NCBI chr 2:210,685,204...210,688,273
Ensembl chr 2:210,685,197...210,688,272
JBrowse link
G Gstm5 glutathione S-transferase, mu 5 multiple interactions ISO [Methionine deficiency co-treated with Homocysteine] affects the expression of GSTM3 protein CTD PMID:17116298 NCBI chr 2:210,685,338...210,688,133
Ensembl chr 2:210,685,197...210,688,272
JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions ISO [GSTP1 gene SNP results in increased susceptibility to [Air Pollutants results in increased abundance of Particulate Matter]] which results in increased abundance of Homocysteine CTD PMID:30477822 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
G H3f4 H3.4 histone multiple interactions ISO Homocysteine promotes the reaction [H3-4 protein modified form binds to CCNA1 promoter] CTD PMID:17698632 NCBI chr10:45,304,696...45,305,106 JBrowse link
G H4f16 H4 histone 16 multiple interactions ISO Homocysteine promotes the reaction [H4-16 protein modified form binds to CCNA1 promoter] CTD PMID:17698632 NCBI chr17:43,821,122...43,821,587 JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions
increases expression
ISO Glycine inhibits the reaction [Homocysteine results in increased expression of HSPA5 mRNA]
Homocysteine results in increased expression of HSPA5 mRNA; Homocysteine results in increased expression of HSPA5 protein
CTD PMID:19960509 PMID:27064126 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
JBrowse link
G Isl1 ISL LIM homeobox 1 affects expression
multiple interactions
ISO Homocysteine affects the expression of ISL1 mRNA
Folic Acid inhibits the reaction [Homocysteine affects the expression of ISL1 mRNA]; Inositol promotes the reaction [Folic Acid inhibits the reaction [Homocysteine affects the expression of ISL1 mRNA]]
CTD PMID:19638421 NCBI chr 2:48,488,911...48,501,217
Ensembl chr 2:48,487,736...48,501,436
JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 increases expression ISO Homocysteine results in increased expression of KEAP1 protein CTD PMID:22964297 NCBI chr 8:22,250,518...22,259,868
Ensembl chr 8:22,250,518...22,259,779
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation
ISO 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK1 protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK1 protein]; [1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester co-treated with Genistein] inhibits the reaction [Thapsigargin promotes the reaction [Homocysteine results in increased phosphorylation of MAPK1 protein]]; Acetylcysteine inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK1 protein]; Folic Acid inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK1 protein]; fulvic acid inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK1 protein]; Genistein inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK1 protein]; Genistein inhibits the reaction [Thapsigargin promotes the reaction [Homocysteine results in increased phosphorylation of MAPK1 protein]]; Go 6976 inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK1 protein]; Pertussis Toxin inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK1 protein]; Phorbol 12,13-Dibutyrate inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK1 protein]; Phorbol 12,13-Dibutyrate promotes the reaction [Homocysteine results in increased phosphorylation of MAPK1 protein]; Staurosporine inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK1 protein]; Tetradecanoylphorbol Acetate promotes the reaction [Homocysteine results in increased phosphorylation of MAPK1 protein]; Thapsigargin promotes the reaction [Homocysteine results in increased phosphorylation of MAPK1 protein]; U 0126 inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK1 protein]
6-Cyano-7-nitroquinoxaline-2,3-dione inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK1 protein]; 6-methyl-2-(phenylethynyl)pyridine inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK1 protein]; alpha-methyl-4-carboxyphenylglycine inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK1 protein]; Cystine affects the reaction [Homocysteine results in increased phosphorylation of MAPK1 protein]; Dizocilpine Maleate inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK1 protein]; N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK1 protein]; RTKI cpd inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK1 protein]
CTD PMID:16251475 PMID:19850060 PMID:25888188 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk14 mitogen activated protein kinase 14 multiple interactions
increases phosphorylation
ISO Acetylcysteine inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK14 protein]; Atorvastatin inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK14 protein]; diphenyleneiodonium inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK14 protein]; NOX4 mutant form inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK14 protein]; SB 203580 inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK14 protein] CTD PMID:19767766 PMID:20018284 PMID:20305681 NCBI chr20:5,933,290...5,995,137
Ensembl chr20:5,933,303...5,995,137
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation
ISO 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK3 protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK3 protein]; [1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester co-treated with Genistein] inhibits the reaction [Thapsigargin promotes the reaction [Homocysteine results in increased phosphorylation of MAPK3 protein]]; Acetylcysteine inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK3 protein]; Folic Acid inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK3 protein]; fulvic acid inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK3 protein]; Genistein inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK3 protein]; Genistein inhibits the reaction [Thapsigargin promotes the reaction [Homocysteine results in increased phosphorylation of MAPK3 protein]]; Go 6976 inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK3 protein]; Pertussis Toxin inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK3 protein]; Phorbol 12,13-Dibutyrate inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK3 protein]; Phorbol 12,13-Dibutyrate promotes the reaction [Homocysteine results in increased phosphorylation of MAPK3 protein]; Staurosporine inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK3 protein]; Tetradecanoylphorbol Acetate promotes the reaction [Homocysteine results in increased phosphorylation of MAPK3 protein]; Thapsigargin promotes the reaction [Homocysteine results in increased phosphorylation of MAPK3 protein]; U 0126 inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK3 protein]
6-Cyano-7-nitroquinoxaline-2,3-dione inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK3 protein]; 6-methyl-2-(phenylethynyl)pyridine inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK3 protein]; alpha-methyl-4-carboxyphenylglycine inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK3 protein]; Cystine affects the reaction [Homocysteine results in increased phosphorylation of MAPK3 protein]; Dizocilpine Maleate inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK3 protein]; N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK3 protein]; RTKI cpd inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK3 protein]
CTD PMID:16251475 PMID:19850060 PMID:25888188 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases phosphorylation
multiple interactions
ISO Homocysteine results in increased phosphorylation of MAPK8 protein
fulvic acid inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK8 protein]
CTD PMID:25888188 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 increases phosphorylation
multiple interactions
ISO Homocysteine results in increased phosphorylation of MAPK9 protein
fulvic acid inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK9 protein]
CTD PMID:25888188 NCBI chr10:35,333,859...35,374,364
Ensembl chr10:35,333,859...35,374,355
JBrowse link
G Mecp2 methyl CpG binding protein 2 multiple interactions ISO Homocysteine inhibits the reaction [MECP2 protein binds to CCNA1 promoter] CTD PMID:17698632 NCBI chr  X:156,650,389...156,713,813
Ensembl chr  X:156,655,960...156,705,233
JBrowse link
G Mmp1 matrix metallopeptidase 1 multiple interactions EXP Dizocilpine Maleate inhibits the reaction [Homocysteine analog results in decreased expression of and results in decreased activity of MMP1 protein]; Homocysteine analog results in decreased expression of and results in decreased activity of MMP1 protein CTD PMID:20406136 NCBI chr 8:5,703,206...5,723,593
Ensembl chr 8:5,703,206...5,723,591
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions
decreases expression
increases expression
increases activity
ISO
EXP
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Homocysteine results in increased activity of MMP9 protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Homocysteine results in increased expression of MMP9 protein]; Acetylcysteine inhibits the reaction [Homocysteine results in increased activity of MMP9 protein]; Acetylcysteine inhibits the reaction [Homocysteine results in increased expression of MMP9 protein]; Staurosporine inhibits the reaction [Homocysteine results in increased activity of MMP9 protein]; Staurosporine inhibits the reaction [Homocysteine results in increased expression of MMP9 protein]
Dizocilpine Maleate inhibits the reaction [Homocysteine analog results in decreased expression of MMP9 protein]
Homocysteine results in increased activity of and results in increased expression of MMP9 protein
CTD PMID:16251475 PMID:20406136 PMID:22326992 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Mt1 metallothionein 1 multiple interactions
decreases expression
EXP [Folic Acid co-treated with Zinc] inhibits the reaction [Homocysteine results in decreased expression of MT1A mRNA]; Folic Acid inhibits the reaction [Homocysteine results in decreased expression of MT1A mRNA]; Zinc inhibits the reaction [Homocysteine results in decreased expression of MT1A mRNA] CTD PMID:19641857 NCBI chr19:11,301,991...11,303,007
Ensembl chr17:78,793,336...78,793,724
JBrowse link
G Mthfr methylenetetrahydrofolate reductase increases expression
multiple interactions
affects abundance
decreases methylation
increases abundance
affects metabolic processing
ISO Homocysteine results in increased expression of MTHFR protein
[MTHFR gene mutant form co-treated with Methotrexate] results in increased abundance of Homocysteine
MTHFR protein affects the abundance of Homocysteine metabolite
Homocysteine inhibits the reaction [Simvastatin results in increased expression of MTHFR protein modified form]; Simvastatin promotes the reaction [Homocysteine results in increased expression of MTHFR protein]
MTHFR protein SNP results in decreased methylation of Homocysteine
MTHFR gene polymorphism results in increased abundance of Homocysteine; MTHFR protein mutant form results in increased abundance of Homocysteine
MTHFR protein affects the metabolism of Homocysteine
CTD PMID:7647779 PMID:17387702 PMID:18540024 PMID:19204075 PMID:19593106 PMID:19646848 PMID:20547447 NCBI chr 5:164,844,642...164,864,360
Ensembl chr 5:164,845,925...164,860,910
JBrowse link
G Mtr 5-methyltetrahydrofolate-homocysteine methyltransferase affects metabolic processing
multiple interactions
affects binding
ISO
EXP
MTR gene polymorphism affects the metabolism of Homocysteine
Homocysteine inhibits the reaction [Folic Acid results in increased activity of MTR protein]
Homocysteine binds to MTR protein
CTD PMID:17477549 PMID:20532609 PMID:31721048 NCBI chr17:66,210,444...66,295,014
Ensembl chr17:66,210,461...66,295,014
JBrowse link
G Mtrr 5-methyltetrahydrofolate-homocysteine methyltransferase reductase affects abundance ISO MTRR protein affects the abundance of Homocysteine CTD PMID:17369066 NCBI chr 1:37,743,089...37,774,485
Ensembl chr 1:37,743,147...37,774,015
JBrowse link
G Ncf1 neutrophil cytosolic factor 1 affects localization
increases phosphorylation
multiple interactions
ISO Homocysteine affects the localization of NCF1 protein
Homocysteine results in increased phosphorylation of NCF1 protein
Filipin inhibits the reaction [Homocysteine affects the localization of NCF1 protein]; methyl-beta-cyclodextrin inhibits the reaction [Homocysteine affects the localization of NCF1 protein]
Folic Acid inhibits the reaction [Homocysteine results in increased phosphorylation of NCF1 protein]; Homocysteine promotes the reaction [NCF1 protein results in increased abundance of Reactive Oxygen Species]; Homocysteine results in increased localization of and results in increased activity of NCF1 protein
CTD PMID:16845898 PMID:17586618 PMID:20036696 NCBI chr12:25,497,104...25,506,300
Ensembl chr12:25,497,104...25,506,300
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 affects localization
multiple interactions
increases expression
ISO Homocysteine affects the localization of NFE2L2 protein modified form
acetyl-aspartyl-glutamyl-valyl-aspartal inhibits the reaction [Homocysteine results in decreased expression of NFE2L2 protein]; Homocysteine results in decreased phosphorylation of and results in decreased expression of NFE2L2 protein; L 709049 inhibits the reaction [Homocysteine results in decreased expression of NFE2L2 protein]; N-(4-fluorophenylsulfonyl)-L-valyl-L-leucinal inhibits the reaction [Homocysteine results in decreased phosphorylation of and results in decreased expression of NFE2L2 protein]
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Homocysteine results in decreased phosphorylation of and results in decreased expression of NFE2L2 protein]; Homocysteine results in decreased phosphorylation of and results in decreased expression of NFE2L2 protein
Homocysteine results in increased expression of NFE2L2 mRNA
CTD PMID:22964297 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions
increases degradation
ISO [Adenosine co-treated with Homocysteine] affects the reaction [TNF protein results in increased phosphorylation of NFKBIA protein]; [Adenosine co-treated with Homocysteine] inhibits the reaction [TNF protein results in increased expression of NFKBIA mRNA]; [Adenosine co-treated with Homocysteine] results in decreased expression of NFKBIA mRNA; [Homocysteine results in increased expression of CCL2 protein] which results in increased phosphorylation of NFKBIA protein; [Homocysteine results in increased expression of CCL2 protein] which results in increased reduction of NFKBIA mRNA; acetovanillone inhibits the reaction [Homocysteine results in increased phosphorylation of and results in increased activity of NFKBIA protein]; Folic Acid inhibits the reaction [Homocysteine results in increased phosphorylation of and results in increased activity of NFKBIA protein]; Homocysteine results in increased phosphorylation of and results in increased activity of NFKBIA protein
Homocysteine results in increased degradation of NFKBIA protein
CTD PMID:11356643 PMID:16845898 PMID:17586618 PMID:24224954 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Nfkbib NFKB inhibitor beta increases degradation ISO Homocysteine results in increased degradation of NFKBIB protein CTD PMID:17586618 NCBI chr 1:86,941,073...86,948,845
Ensembl chr 1:86,941,074...86,948,845
JBrowse link
G Nkx2-5 NK2 homeobox 5 multiple interactions
decreases expression
EXP Particulate Matter promotes the reaction [Homocysteine results in decreased expression of NKX2-5 protein]
Homocysteine results in decreased expression of NKX2-5 mRNA; Homocysteine results in decreased expression of NKX2-5 protein
CTD PMID:27203204 NCBI chr10:16,635,989...16,638,758
Ensembl chr10:16,635,989...16,638,764
JBrowse link
G Nlrc3 NLR family, CARD domain containing 3 multiple interactions
increases expression
ISO [Folic Acid deficiency results in increased abundance of Homocysteine] promotes the reaction [NLRC3 protein binds to PYCARD protein binds to CASP1 protein]; CASP1 protein affects the reaction [Homocysteine promotes the reaction [NLRC3 protein binds to PYCARD protein binds to CASP1 protein]]; Homocysteine promotes the reaction [NLRC3 protein binds to PYCARD protein binds to CASP1 protein]; PYCARD protein affects the reaction [Homocysteine promotes the reaction [NLRC3 protein binds to PYCARD protein binds to CASP1 protein]]
Homocysteine results in increased expression of NLRC3 mRNA
CTD PMID:22647887 NCBI chr10:11,809,531...11,844,184
Ensembl chr10:11,810,926...11,842,482
JBrowse link
G Nos2 nitric oxide synthase 2 increases methylation
increases expression
multiple interactions
ISO Homocysteine results in increased methylation of NOS2 promoter
Homocysteine results in increased expression of NOS2 mRNA
Homocysteine affects the reaction [Simvastatin results in increased expression of NOS2 protein]; Simvastatin promotes the reaction [Homocysteine results in increased expression of NOS2 mRNA]
[Homocysteine results in increased methylation of NOS2 promoter] which results in decreased expression of NOS2 mRNA; Clofibrate inhibits the reaction [Homocysteine results in increased methylation of NOS2 promoter]; pioglitazone inhibits the reaction [Homocysteine results in increased methylation of NOS2 promoter]
CTD PMID:17492134 PMID:18540024 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions
decreases expression
decreases phosphorylation
ISO Folic Acid inhibits the reaction [Homocysteine results in decreased expression of and results in decreased activity of NOS3 protein]; Homocysteine results in decreased expression of and results in decreased activity of NOS3 protein; Zeranol inhibits the reaction [Homocysteine results in decreased expression of NOS3 protein]
Homocysteine results in decreased expression of NOS3 mRNA; Homocysteine results in decreased expression of NOS3 protein
Homocysteine results in decreased phosphorylation of NOS3 protein
Atorvastatin inhibits the reaction [Homocysteine results in decreased expression of NOS3 mRNA]; Atorvastatin inhibits the reaction [Homocysteine results in decreased phosphorylation of NOS3 protein]
CTD PMID:16757814 PMID:17357445 PMID:20305681 NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410
JBrowse link
G Nox4 NADPH oxidase 4 multiple interactions
increases response to substance
increases expression
ISO Atorvastatin inhibits the reaction [Homocysteine results in increased expression of NOX4 mRNA]; NOX4 mutant form inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK14 protein]
NOX4 results in increased susceptibility to Homocysteine
CTD PMID:20018284 NCBI chr 1:150,796,359...150,976,186
Ensembl chr 1:150,797,084...150,976,194
JBrowse link
G Nphs2 NPHS2 stomatin family member, podocin multiple interactions
decreases expression
ISO [Folic Acid deficiency results in increased abundance of Homocysteine] which results in decreased expression of NPHS2 mRNA; acetovanillone inhibits the reaction [Homocysteine results in decreased expression of NPHS2 mRNA]; acetovanillone inhibits the reaction [Homocysteine results in decreased expression of NPHS2 protein]; Amitriptyline inhibits the reaction [Homocysteine results in decreased expression of NPHS2 protein]; CYBB protein mutant form inhibits the reaction [[Folic Acid deficiency results in increased abundance of Homocysteine] which results in decreased expression of NPHS2 mRNA]; diphenyleneiodonium inhibits the reaction [Homocysteine results in decreased expression of NPHS2 mRNA]; diphenyleneiodonium inhibits the reaction [Homocysteine results in decreased expression of NPHS2 protein]; Filipin inhibits the reaction [Homocysteine results in decreased expression of NPHS2 mRNA]; Filipin inhibits the reaction [Homocysteine results in decreased expression of NPHS2 protein]; methyl-beta-cyclodextrin inhibits the reaction [Homocysteine results in decreased expression of NPHS2 mRNA]; methyl-beta-cyclodextrin inhibits the reaction [Homocysteine results in decreased expression of NPHS2 protein]
Homocysteine results in decreased expression of NPHS2 mRNA; Homocysteine results in decreased expression of NPHS2 protein
CTD PMID:20036696 PMID:20116427 PMID:23024785 NCBI chr13:73,929,136...73,941,522
Ensembl chr13:73,929,136...73,941,522
JBrowse link
G Nt5e 5' nucleotidase, ecto affects activity ISO Homocysteine affects the activity of NT5E protein CTD PMID:24055814 NCBI chr 8:95,969,002...96,012,733
Ensembl chr 8:95,968,652...96,012,696
JBrowse link
G Pon1 paraoxonase 1 multiple interactions ISO [Methionine results in increased abundance of Homocysteine] which results in decreased activity of PON1 protein; [resveratrol results in increased abundance of Homocysteine] which results in decreased activity of PON1 protein CTD PMID:19028542 NCBI chr 4:30,249,749...30,276,297
Ensembl chr 4:30,249,742...30,276,372
JBrowse link
G Prdx6 peroxiredoxin 6 multiple interactions ISO [Methionine deficiency co-treated with Homocysteine] affects the expression of PRDX6 protein CTD PMID:17116298 NCBI chr13:79,077,567...79,088,113
Ensembl chr13:79,077,033...79,088,127
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
increases expression
ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Homocysteine results in increased expression of PTGS2 mRNA]; fulvic acid inhibits the reaction [Homocysteine promotes the reaction [RELA protein binds to PTGS2 promoter]]; fulvic acid inhibits the reaction [Homocysteine results in increased expression of PTGS2 mRNA]; Homocysteine promotes the reaction [RELA protein binds to PTGS2 promoter]; pyrazolanthrone inhibits the reaction [Homocysteine results in increased expression of PTGS2 mRNA]; pyrrolidine dithiocarbamic acid inhibits the reaction [Homocysteine results in increased expression of PTGS2 mRNA]; SN50 peptide inhibits the reaction [Homocysteine results in increased expression of PTGS2 mRNA] CTD PMID:25888188 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Pycard PYD and CARD domain containing multiple interactions
increases expression
ISO [Folic Acid deficiency results in increased abundance of Homocysteine] promotes the reaction [NLRC3 protein binds to PYCARD protein binds to CASP1 protein]; CASP1 protein affects the reaction [Homocysteine promotes the reaction [NLRC3 protein binds to PYCARD protein binds to CASP1 protein]]; Homocysteine promotes the reaction [NLRC3 protein binds to PYCARD protein binds to CASP1 protein]; PYCARD protein affects the reaction [Homocysteine promotes the reaction [NLRC3 protein binds to PYCARD protein binds to CASP1 protein]]; PYCARD protein affects the reaction [Homocysteine results in decreased secretion of VEGFA protein]; PYCARD protein affects the reaction [Homocysteine results in increased activity of CASP1 protein]
Homocysteine results in increased expression of PYCARD mRNA
CTD PMID:22647887 NCBI chr 1:199,438,029...199,439,062
Ensembl chr 1:199,437,832...199,439,210
JBrowse link
G Rab1b RAB1B, member RAS oncogene family multiple interactions ISO [Methionine deficiency co-treated with Homocysteine] affects the expression of RAB1B protein CTD PMID:17116298 NCBI chr 1:220,483,529...220,491,469
Ensembl chr 1:220,480,834...220,491,469
JBrowse link
G Rab9a RAB9A, member RAS oncogene family multiple interactions ISO [Methionine deficiency co-treated with Homocysteine] affects the expression of RAB9A protein CTD PMID:17116298 NCBI chr  X:29,525,256...29,547,295
Ensembl chr  X:29,525,256...29,547,294
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
increases expression
increases localization
increases activity
ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Homocysteine results in increased activity of RELA protein]; [Adenosine co-treated with Homocysteine] affects the reaction [TNF protein affects the localization of RELA protein modified form]; [Adenosine co-treated with Homocysteine] affects the reaction [TNF protein results in increased phosphorylation of RELA protein]; fulvic acid inhibits the reaction [Homocysteine promotes the reaction [RELA protein binds to PTGS2 promoter]]; Homocysteine promotes the reaction [RELA protein binds to PTGS2 promoter]; pyrazolanthrone inhibits the reaction [Homocysteine results in increased activity of RELA protein]
Homocysteine results in increased expression of RELA protein
Homocysteine inhibits the reaction [Simvastatin results in decreased expression of RELA protein]
Homocysteine results in increased localization of RELA protein
CTD PMID:17586618 PMID:18540024 PMID:24224954 PMID:25888188 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Ripk1 receptor interacting serine/threonine kinase 1 multiple interactions ISO [Adenosine co-treated with Homocysteine co-treated with TNF protein] results in increased cleavage of RIPK1 protein CTD PMID:24224954 NCBI chr17:31,537,580...31,569,904
Ensembl chr17:31,537,591...31,569,904
JBrowse link
G S100a4 S100 calcium-binding protein A4 multiple interactions
increases expression
ISO [Folic Acid deficiency results in increased abundance of Homocysteine] which results in increased expression of S100A4 mRNA; [Folic Acid deficiency results in increased abundance of Homocysteine] which results in increased expression of S100A4 protein; acetovanillone inhibits the reaction [Homocysteine results in increased expression of S100A4 protein]; CYBB mutant form inhibits the reaction [[Folic Acid deficiency results in increased abundance of Homocysteine] which results in increased expression of S100A4 mRNA]; CYBB mutant form inhibits the reaction [[Folic Acid deficiency results in increased abundance of Homocysteine] which results in increased expression of S100A4 protein]; CYBB mutant form inhibits the reaction [Homocysteine results in increased expression of S100A4 protein]
Homocysteine results in increased expression of S100A4 mRNA; Homocysteine results in increased expression of S100A4 protein
CTD PMID:21647593 NCBI chr 2:189,997,278...189,999,587
Ensembl chr 2:189,997,129...189,999,604
JBrowse link
G Slc46a1 solute carrier family 46 member 1 affects abundance ISO SLC46A1 protein affects the abundance of Homocysteine metabolite CTD PMID:19204075 NCBI chr10:65,728,508...65,741,708
Ensembl chr10:65,733,991...65,740,828
JBrowse link
G Sod1 superoxide dismutase 1 increases expression EXP Homocysteine results in increased expression of SOD1 protein CTD PMID:17485853 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions ISO [SOD2 gene SNP results in increased susceptibility to [Air Pollutants results in increased abundance of Particulate Matter]] which results in increased abundance of Homocysteine CTD PMID:30477822 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Ssr4 signal sequence receptor subunit 4 multiple interactions ISO [Methionine deficiency co-treated with Homocysteine] affects the expression of SSR4 protein CTD PMID:17116298 NCBI chr  X:156,995,763...156,999,702
Ensembl chr  X:156,995,779...156,999,650
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 multiple interactions
increases expression
EXP Dizocilpine Maleate inhibits the reaction [Homocysteine analog results in increased expression of TIMP1 mRNA]; Dizocilpine Maleate inhibits the reaction [Homocysteine analog results in increased expression of TIMP1 protein]
Homocysteine analog results in increased expression of TIMP1 mRNA; Homocysteine analog results in increased expression of TIMP1 protein
CTD PMID:20406136 NCBI chr  X:1,364,771...1,369,451
Ensembl chr  X:1,364,786...1,369,384
JBrowse link
G Tjp1 tight junction protein 1 multiple interactions
decreases expression
ISO [Folic Acid deficiency results in increased abundance of Homocysteine] which results in decreased expression of TJP1 mRNA; acetovanillone inhibits the reaction [Homocysteine results in decreased expression of TJP1 protein]; CYBB mutant form inhibits the reaction [[Folic Acid deficiency results in increased abundance of Homocysteine] which results in decreased expression of TJP1 mRNA]; CYBB mutant form inhibits the reaction [Homocysteine results in decreased expression of TJP1 protein]
Homocysteine results in decreased expression of TJP1 mRNA; Homocysteine results in decreased expression of TJP1 protein
CTD PMID:21647593 NCBI chr 1:126,146,489...126,515,359
Ensembl chr 1:126,146,489...126,227,469
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression
ISO
EXP
[Adenosine co-treated with Homocysteine co-treated with TNF protein] results in increased cleavage of RIPK1 protein; [Adenosine co-treated with Homocysteine] affects the reaction [TNF protein affects the localization of RELA protein modified form]; [Adenosine co-treated with Homocysteine] affects the reaction [TNF protein results in increased phosphorylation of NFKBIA protein]; [Adenosine co-treated with Homocysteine] affects the reaction [TNF protein results in increased phosphorylation of RELA protein]; [Adenosine co-treated with Homocysteine] inhibits the reaction [TNF protein results in increased expression of CXCL8 mRNA]; [Adenosine co-treated with Homocysteine] inhibits the reaction [TNF protein results in increased expression of NFKBIA mRNA]; [Adenosine co-treated with Homocysteine] inhibits the reaction [TNF protein results in increased expression of TNFAIP3 mRNA]; [Adenosine co-treated with Homocysteine] inhibits the reaction [TNF protein results in increased expression of TNFAIP3 protein]; [Adenosine co-treated with Homocysteine] results in increased susceptibility to TNF protein
Homocysteine results in increased expression of TNF protein
CTD PMID:24224954 PMID:27203204 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tnfaip3 TNF alpha induced protein 3 multiple interactions ISO [Adenosine co-treated with Homocysteine] inhibits the reaction [TNF protein results in increased expression of TNFAIP3 mRNA]; [Adenosine co-treated with Homocysteine] inhibits the reaction [TNF protein results in increased expression of TNFAIP3 protein]; [Adenosine co-treated with Homocysteine] results in decreased expression of TNFAIP3 mRNA; [Adenosine co-treated with Homocysteine] results in decreased expression of TNFAIP3 protein CTD PMID:24224954 NCBI chr 1:14,401,103...14,416,369
Ensembl chr 1:14,402,913...14,412,807
JBrowse link
G Tp53 tumor protein p53 increases phosphorylation
affects expression
multiple interactions
EXP
ISO
Homocysteine results in increased phosphorylation of TP53 protein
Homocysteine affects the expression of TP53 mRNA; Homocysteine affects the expression of TP53 protein
Folic Acid affects the reaction [Homocysteine affects the expression of TP53 mRNA]; Folic Acid affects the reaction [Homocysteine affects the expression of TP53 protein]
CTD PMID:13679428 PMID:29250709 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Vbp1 VHL binding protein 1 multiple interactions ISO [Methionine deficiency co-treated with Homocysteine] affects the expression of VBP1 protein CTD PMID:17116298 NCBI chr 1:148,425,046...148,443,505
Ensembl chr 1:148,424,977...148,443,358
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions
increases expression
ISO 3,4-dihydroxyphenylethanol inhibits the reaction [Homocysteine results in increased expression of VCAM1 protein]; resveratrol inhibits the reaction [Homocysteine results in increased expression of VCAM1 protein]
Homocysteine results in increased expression of VCAM1 mRNA; Homocysteine results in increased expression of VCAM1 protein
CTD PMID:17586618 NCBI chr 2:219,071,193...219,090,931
Ensembl chr 2:219,071,193...219,097,619
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions
increases expression
decreases expression
decreases secretion
ISO
EXP
Amitriptyline inhibits the reaction [Homocysteine results in decreased secretion of VEGFA protein]; CASP1 protein affects the reaction [Homocysteine results in decreased secretion of VEGFA protein]; CYBB protein affects the reaction [Homocysteine results in decreased secretion of VEGFA protein]; diphenyleneiodonium inhibits the reaction [Homocysteine results in decreased secretion of VEGFA protein]; Homocysteine results in decreased expression of and results in decreased secretion of VEGFA protein; PYCARD protein affects the reaction [Homocysteine results in decreased secretion of VEGFA protein]
Homocysteine results in increased expression of VEGFA protein
Homocysteine results in decreased expression of VEGFA mRNA
CTD PMID:17485853 PMID:20116427 PMID:22647887 PMID:23024785 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
G Vim vimentin increases expression EXP Homocysteine results in increased expression of VIM protein CTD PMID:17485853 NCBI chr17:80,882,715...80,891,200
Ensembl chr17:80,882,666...80,891,212
JBrowse link
G Vps29 VPS29 retromer complex component multiple interactions ISO [Methionine deficiency co-treated with Homocysteine] affects the expression of VPS29 protein CTD PMID:17116298 NCBI chr12:39,690,069...39,699,114
Ensembl chr12:39,690,069...39,699,113
JBrowse link
G Wnt5a Wnt family member 5A decreases expression ISO Homocysteine results in decreased expression of WNT5A mRNA CTD PMID:17320366 NCBI chr16:4,469,451...4,490,271
Ensembl chr16:4,469,468...4,489,860
JBrowse link
G Xbp1 X-box binding protein 1 multiple interactions
decreases expression
increases expression
increases splicing
ISO Glycine affects the reaction [Homocysteine results in increased splicing of XBP1 mRNA]
Homocysteine results in decreased expression of XBP1 protein
Homocysteine results in increased expression of XBP1 mRNA alternative form
CTD PMID:19960509 PMID:22964297 PMID:27064126 NCBI chr14:85,753,736...85,758,820
Ensembl chr14:85,753,760...85,758,145
JBrowse link
L-cystathionine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ins2 insulin 2 multiple interactions ISO [1-Methyl-3-isobutylxanthine co-treated with butylbenzyl phthalate co-treated with INS protein] results in increased abundance of Cystathionine analog CTD PMID:26820058 NCBI chr 1:215,856,967...215,858,034
Ensembl chr 1:215,856,971...215,858,034
JBrowse link
G Kyat1 kynurenine aminotransferase 1 increases amination ISO KYAT1 protein results in increased amination of Cystathionine CTD PMID:22093698 NCBI chr 3:8,752,289...8,785,617
Ensembl chr 3:8,752,625...8,766,433
JBrowse link
G Mmp1 matrix metallopeptidase 1 multiple interactions ISO Cystathionine inhibits the reaction [Formaldehyde results in increased expression of MMP1 protein] CTD PMID:27664576 NCBI chr 8:5,703,206...5,723,593
Ensembl chr 8:5,703,206...5,723,591
JBrowse link
S-adenosyl-L-homocysteine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahcy adenosylhomocysteinase increases hydrolysis ISO AHCY results in increased hydrolysis of S-Adenosylhomocysteine CTD PMID:26974671 NCBI chr 3:150,587,833...150,603,057
Ensembl chr 3:150,587,833...150,603,082
JBrowse link
G Ahr aryl hydrocarbon receptor increases abundance
multiple interactions
ISO AHR protein results in increased abundance of S-Adenosylhomocysteine
PEMT protein promotes the reaction [AHR protein results in increased abundance of S-Adenosylhomocysteine]
CTD PMID:29416063 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Alas2 5'-aminolevulinate synthase 2 multiple interactions ISO [S-Adenosylhomocysteine co-treated with Hemin] results in increased expression of ALAS2 mRNA; catechol inhibits the reaction [[S-Adenosylhomocysteine co-treated with Hemin] results in increased expression of ALAS2 mRNA] CTD PMID:24141029 NCBI chr  X:23,167,576...23,187,356
Ensembl chr  X:23,167,696...23,187,341
JBrowse link
G App amyloid beta precursor protein increases expression
decreases methylation
multiple interactions
ISO S-Adenosylhomocysteine results in increased expression of APP protein
S-Adenosylhomocysteine results in decreased methylation of APP promoter
Betaine inhibits the reaction [S-Adenosylhomocysteine results in decreased methylation of APP promoter]; Betaine inhibits the reaction [S-Adenosylhomocysteine results in increased expression of and results in increased cleavage of APP protein]; S-Adenosylhomocysteine results in increased expression of and results in increased cleavage of APP protein
CTD PMID:19635394 PMID:22064374 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
JBrowse link
G Atp7b ATPase copper transporting beta increases abundance ISO ATP7B protein mutant form results in increased abundance of S-Adenosylhomocysteine CTD PMID:22945834 NCBI chr16:74,865,516...74,944,935
Ensembl chr16:74,865,516...74,945,286
JBrowse link
G Bace1 beta-secretase 1 increases expression ISO S-Adenosylhomocysteine results in increased expression of BACE1 protein CTD PMID:19635394 NCBI chr 8:50,140,092...50,162,388
Ensembl chr 8:50,139,997...50,162,361
JBrowse link
G Col1a1 collagen type I alpha 1 chain decreases expression ISO S-Adenosylhomocysteine results in decreased expression of COL1A1 mRNA CTD PMID:15983038 NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789
JBrowse link
G Col1a2 collagen type I alpha 2 chain decreases expression ISO S-Adenosylhomocysteine results in decreased expression of COL1A2 mRNA CTD PMID:15983038 NCBI chr 4:31,534,225...31,569,152
Ensembl chr 4:31,534,225...31,569,151
JBrowse link
G Comt catechol-O-methyltransferase decreases activity EXP S-Adenosylhomocysteine results in decreased activity of COMT protein CTD PMID:10064789 NCBI chr11:86,715,981...86,735,630
Ensembl chr11:86,715,981...86,735,622
JBrowse link
G Dnmt1 DNA methyltransferase 1 decreases activity
multiple interactions
ISO S-Adenosylhomocysteine results in decreased activity of DNMT1 protein
S-Adenosylhomocysteine inhibits the reaction [DNMT1 protein binds to OGG1 promoter]
CTD PMID:16037419 PMID:22064374 NCBI chr 8:21,922,515...21,968,495
Ensembl chr 8:21,922,515...21,968,495
JBrowse link
G Fgf19 fibroblast growth factor 19 decreases abundance ISO FGF19 protein results in decreased abundance of S-Adenosylhomocysteine CTD PMID:29416063 NCBI chr 1:218,058,405...218,061,693
Ensembl chr 1:218,058,405...218,061,693
JBrowse link
G Hbb hemoglobin subunit beta multiple interactions ISO [S-Adenosylhomocysteine co-treated with Hemin] results in increased expression of HBB mRNA; catechol inhibits the reaction [[S-Adenosylhomocysteine co-treated with Hemin] results in increased expression of HBB mRNA] CTD PMID:24141029 NCBI chr 1:168,971,269...168,972,680
Ensembl chr 1:168,971,274...168,972,725
JBrowse link
G Hmbs hydroxymethylbilane synthase multiple interactions ISO [S-Adenosylhomocysteine co-treated with Hemin] results in increased expression of HMBS mRNA; catechol inhibits the reaction [[S-Adenosylhomocysteine co-treated with Hemin] results in increased expression of HMBS mRNA] CTD PMID:24141029 NCBI chr 8:48,667,278...48,674,673
Ensembl chr 8:48,667,275...48,674,748
JBrowse link
G Mmp2 matrix metallopeptidase 2 increases expression
multiple interactions
ISO
EXP
S-Adenosylhomocysteine results in increased expression of MMP2 mRNA; S-Adenosylhomocysteine results in increased expression of MMP2 protein
S-Adenosylhomocysteine promotes the reaction [SP1 protein binds to MMP2 promoter]
U 0126 inhibits the reaction [S-Adenosylhomocysteine results in increased expression of MMP2 protein]
CTD PMID:19770485 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
JBrowse link
G Nfkbia NFKB inhibitor alpha decreases expression EXP S-Adenosylhomocysteine results in decreased expression of NFKBIA protein CTD PMID:19770485 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 decreases abundance ISO NR0B2 protein results in decreased abundance of S-Adenosylhomocysteine CTD PMID:29416063 NCBI chr 5:151,776,004...151,779,319
Ensembl chr 5:151,776,004...151,779,319
JBrowse link
G Ogg1 8-oxoguanine DNA glycosylase multiple interactions
decreases methylation
decreases expression
ISO Betaine inhibits the reaction [S-Adenosylhomocysteine results in decreased expression of OGG1 protein]; Betaine inhibits the reaction [S-Adenosylhomocysteine results in decreased methylation of OGG1 promoter]; S-Adenosylhomocysteine inhibits the reaction [DNMT1 protein binds to OGG1 promoter]
S-Adenosylhomocysteine results in decreased expression of OGG1 mRNA; S-Adenosylhomocysteine results in decreased expression of OGG1 protein
CTD PMID:22064374 NCBI chr 4:145,282,828...145,289,367
Ensembl chr 4:145,282,797...145,289,326
JBrowse link
G Pemt phosphatidylethanolamine N-methyltransferase multiple interactions ISO PEMT protein promotes the reaction [AHR protein results in increased abundance of S-Adenosylhomocysteine] CTD PMID:29416063 NCBI chr10:46,339,821...46,404,640
Ensembl chr10:46,339,821...46,404,642
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha increases expression ISO S-Adenosylhomocysteine results in increased expression of PPARGC1A mRNA CTD PMID:23056435 NCBI chr14:63,095,291...63,190,688
Ensembl chr14:63,095,720...63,187,009
JBrowse link
G Psen1 presenilin 1 multiple interactions
decreases methylation
increases expression
ISO Betaine inhibits the reaction [S-Adenosylhomocysteine results in decreased methylation of PSEN1 promoter]
S-Adenosylhomocysteine results in increased expression of PSEN1 protein
CTD PMID:19635394 NCBI chr 6:107,169,514...107,221,000
Ensembl chr 6:107,169,528...107,216,798
JBrowse link
G Slc19a1 solute carrier family 19 member 1 affects abundance ISO SLC19A1 protein affects the abundance of S-Adenosylhomocysteine CTD PMID:15705887 NCBI chr20:12,334,675...12,354,517
Ensembl chr20:12,334,676...12,352,377
JBrowse link
G Sp1 Sp1 transcription factor multiple interactions EXP S-Adenosylhomocysteine promotes the reaction [SP1 protein binds to MMP2 promoter] CTD PMID:19770485 NCBI chr 7:144,014,173...144,044,635
Ensembl chr 7:144,014,173...144,044,629
JBrowse link
G Timp2 TIMP metallopeptidase inhibitor 2 decreases expression ISO S-Adenosylhomocysteine results in decreased expression of TIMP2 protein CTD PMID:19770485 NCBI chr10:107,338,465...107,386,072
Ensembl chr10:107,338,465...107,386,072
JBrowse link
S-butyl-DL-homocysteine (S,R)-sulfoximine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc1 ATP binding cassette subfamily C member 1 affects localization
multiple interactions
ISO Buthionine Sulfoximine affects the localization of ABCC1 protein mutant form
[Buthionine Sulfoximine results in decreased abundance of Glutathione] inhibits the reaction [ABCC1 results in decreased susceptibility to arsenite]; [Buthionine Sulfoximine results in decreased abundance of Glutathione] inhibits the reaction [ABCC1 results in decreased susceptibility to monomethylarsonous acid analog]; Buthionine Sulfoximine analog inhibits the reaction [Acetylcysteine promotes the reaction [ABCC1 protein results in decreased susceptibility to Doxorubicin]]; Buthionine Sulfoximine inhibits the reaction [ABCC1 protein results in decreased susceptibility to Vincristine]; Buthionine Sulfoximine inhibits the reaction [ABCC1 results in decreased susceptibility to arsenite]; Buthionine Sulfoximine inhibits the reaction [ABCC1 results in decreased susceptibility to methylarsine analog]
CTD PMID:15180633 PMID:15473893 PMID:15581632 PMID:21918036 NCBI chr10:549,537...672,235
Ensembl chr10:549,883...672,196
JBrowse link
G Acin1 apoptotic chromatin condensation inducer 1 increases expression EXP Buthionine Sulfoximine results in increased expression of ACIN1 protein CTD PMID:23736079 NCBI chr15:33,288,369...33,333,256
Ensembl chr15:33,288,374...33,333,417
JBrowse link
G Aco2 aconitase 2 decreases activity ISO Buthionine Sulfoximine results in decreased activity of ACO2 protein CTD PMID:18552690 NCBI chr 7:123,102,493...123,145,608
Ensembl chr 7:123,102,468...123,145,635
JBrowse link
G Actb actin, beta decreases expression ISO Buthionine Sulfoximine results in decreased expression of ACTB mRNA CTD PMID:15878706 NCBI chr12:13,715,843...13,718,813
Ensembl chr12:13,715,843...13,718,841
JBrowse link
G Add3 adducin 3 increases expression ISO Buthionine Sulfoximine results in increased expression of ADD3 mRNA CTD PMID:15878706 NCBI chr 1:273,854,195...273,961,982
Ensembl chr 1:273,854,248...273,961,982
JBrowse link
G Adh1 alcohol dehydrogenase 1 (class I) multiple interactions EXP Buthionine Sulfoximine promotes the reaction [Ethanol results in increased expression of ADH1 mRNA] CTD PMID:20705415 NCBI chr 2:243,550,655...243,562,243
Ensembl chr 2:243,550,627...243,687,857
JBrowse link
G Aimp1 aminoacyl tRNA synthetase complex-interacting multifunctional protein 1 increases expression ISO Buthionine Sulfoximine results in increased expression of AIMP1 mRNA CTD PMID:15878706 NCBI chr 2:237,727,782...237,751,327
Ensembl chr 2:237,727,764...237,751,378
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO Buthionine Sulfoximine promotes the reaction [Cadmium Chloride results in increased phosphorylation of AKT1 protein]; Buthionine Sulfoximine promotes the reaction [Cadmium results in increased phosphorylation of AKT1 protein] CTD PMID:24449419 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Alad aminolevulinate dehydratase decreases activity EXP Buthionine Sulfoximine results in decreased activity of ALAD protein CTD PMID:21620807 NCBI chr 5:78,368,867...78,379,206
Ensembl chr 5:78,368,867...78,379,346
JBrowse link
G Alas1 5'-aminolevulinate synthase 1 multiple interactions EXP Buthionine Sulfoximine inhibits the reaction [1,2,4-trichlorobenzene results in increased activity of ALAS1 protein] CTD PMID:11996131 NCBI chr 8:114,927,704...114,941,038
Ensembl chr 8:114,927,722...114,940,177
JBrowse link
G Alb albumin multiple interactions EXP [Aflatoxin B1 co-treated with Buthionine Sulfoximine] results in increased expression of ALB mRNA CTD PMID:23288050 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
JBrowse link
G Aldoa aldolase, fructose-bisphosphate A increases expression EXP Buthionine Sulfoximine results in increased expression of ALDOA mRNA; Buthionine Sulfoximine results in increased expression of ALDOA protein CTD PMID:11841787 PMID:23736079 NCBI chr 1:198,228,387...198,233,988
Ensembl chr 1:198,228,387...198,233,588
JBrowse link
G Ambp alpha-1-microglobulin/bikunin precursor multiple interactions EXP [Aflatoxin B1 co-treated with Buthionine Sulfoximine] results in increased expression of AMBP mRNA CTD PMID:23288050 NCBI chr 5:78,975,690...78,986,021
Ensembl chr 5:78,975,678...78,985,990
JBrowse link
G Apex1 apurinic/apyrimidinic endodeoxyribonuclease 1 increases expression EXP Buthionine Sulfoximine results in increased expression of APEX1 protein CTD PMID:23736079 NCBI chr15:27,849,943...27,852,083
Ensembl chr15:27,849,979...27,852,082
JBrowse link
G Apoh apolipoprotein H multiple interactions EXP [Aflatoxin B1 co-treated with Buthionine Sulfoximine] results in increased expression of APOH mRNA CTD PMID:23288050 NCBI chr10:96,640,013...96,653,939
Ensembl chr10:96,639,924...96,653,938
JBrowse link
G Arnt aryl hydrocarbon receptor nuclear translocator decreases expression ISO Buthionine Sulfoximine results in decreased expression of ARNT protein CTD PMID:16880289 NCBI chr 2:196,594,178...196,651,486
Ensembl chr 2:196,594,303...196,651,179
JBrowse link
G Atp2a2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 decreases expression ISO Buthionine Sulfoximine results in decreased expression of ATP2A2 protein CTD PMID:18552690 NCBI chr12:39,553,903...39,603,326
Ensembl chr12:39,553,903...39,603,326
JBrowse link
G Atp5f1b ATP synthase F1 subunit beta increases expression ISO Buthionine Sulfoximine results in increased expression of ATP5B mRNA CTD PMID:15878706 NCBI chr 7:2,504,708...2,511,748
Ensembl chr 7:2,504,695...2,511,749
JBrowse link
G Atxn1 ataxin 1 affects localization
multiple interactions
ISO Buthionine Sulfoximine affects the localization of ATXN1 protein mutant form
Buthionine Sulfoximine promotes the reaction [Hydrogen Peroxide affects the localization of ATXN1 protein mutant form]; Buthionine Sulfoximine promotes the reaction [tert-Butylhydroperoxide affects the localization of ATXN1 protein mutant form]
CTD PMID:12893416 NCBI chr17:19,160,986...19,533,814
Ensembl chr17:19,249,952...19,533,814
JBrowse link
G Axl Axl receptor tyrosine kinase increases expression ISO Buthionine Sulfoximine results in increased expression of AXL mRNA CTD PMID:15878706 NCBI chr 1:82,550,892...82,580,761
Ensembl chr 1:82,549,420...82,580,761
JBrowse link
G Azin1 antizyme inhibitor 1 decreases expression ISO Buthionine Sulfoximine results in decreased expression of AZIN1 mRNA CTD PMID:15878706 NCBI chr 7:77,345,646...77,372,398
Ensembl chr 7:77,345,646...77,372,398
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression
multiple interactions
ISO Buthionine Sulfoximine results in increased expression of BAX protein
[Cadmium Chloride co-treated with Buthionine Sulfoximine] results in decreased expression of BAX protein; Acetylcysteine inhibits the reaction [[Cadmium Chloride co-treated with Buthionine Sulfoximine] results in decreased expression of BAX protein]
CTD PMID:11341981 PMID:18552690 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions
ISO
EXP
Buthionine Sulfoximine results in decreased expression of BCL2 mRNA; Buthionine Sulfoximine results in decreased expression of BCL2 protein
Buthionine Sulfoximine promotes the reaction [cyanoginosin LR results in decreased expression of BCL2 protein]
[Cadmium Chloride co-treated with Buthionine Sulfoximine] results in increased expression of BCL2 protein; Acetylcysteine inhibits the reaction [[Cadmium Chloride co-treated with Buthionine Sulfoximine] results in increased expression of BCL2 protein]
Sodium Selenite promotes the reaction [Buthionine Sulfoximine results in decreased expression of BCL2 mRNA]
CTD PMID:11341981 PMID:17989939 PMID:18552690 PMID:25410294 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bmp1 bone morphogenetic protein 1 decreases expression ISO Buthionine Sulfoximine results in decreased expression of BMP1 mRNA CTD PMID:15878706 NCBI chr15:52,166,401...52,210,786
Ensembl chr15:52,166,401...52,210,746
JBrowse link
G Calr calreticulin increases expression EXP Buthionine Sulfoximine results in increased expression of CALR protein CTD PMID:23736079 NCBI chr19:25,956,771...25,961,666
Ensembl chr19:25,956,771...25,961,666
JBrowse link
G Casp3 caspase 3 multiple interactions
increases expression
increases activity
ISO
EXP
4-amylcinnamoylanthranilic acid inhibits the reaction [Buthionine Sulfoximine results in increased activity of CASP3 protein]; Glutathione inhibits the reaction [Buthionine Sulfoximine results in increased activity of CASP3 protein]; Sodium Selenite promotes the reaction [Buthionine Sulfoximine results in increased expression of CASP3 mRNA]
[O(2)-(2,4-dinitrophenyl) 1-((4-ethoxycarbonyl)piperazin-1-yl)diazen-1-ium-1,2-diolate co-treated with Buthionine Sulfoximine] results in increased cleavage of CASP3 protein; Buthionine Sulfoximine promotes the reaction [arsenic trioxide results in increased activity of CASP3 protein]; Buthionine Sulfoximine promotes the reaction [pterostilbene results in increased activity of CASP3 protein]
[Buthionine Sulfoximine co-treated with Arsenic Trioxide] results in increased activity of CASP3 protein; [monomethylarsonic acid co-treated with Buthionine Sulfoximine] results in increased activity of CASP3 protein; Buthionine Sulfoximine inhibits the reaction [Cacodylic Acid results in increased activity of CASP3 protein]; Buthionine Sulfoximine promotes the reaction [Vitamin K 3 results in increased activity of CASP3 protein]
CTD PMID:10673743 PMID:15276415 PMID:15963344 PMID:16310883 PMID:17200146 PMID:17989939 PMID:20962031 PMID:25003661 PMID:25341683 PMID:27592447 PMID:33309544 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp4 caspase 4 multiple interactions ISO Buthionine Sulfoximine promotes the reaction [pterostilbene results in increased activity of CASP4 protein] CTD PMID:25341683 NCBI chr 8:2,616,391...2,651,682
Ensembl chr 8:2,635,851...2,651,652
JBrowse link
G Casp7 caspase 7 multiple interactions ISO Buthionine Sulfoximine promotes the reaction [O(2)-(2,4-dinitrophenyl) 1-((4-ethoxycarbonyl)piperazin-1-yl)diazen-1-ium-1,2-diolate affects the cleavage of CASP7 protein] CTD PMID:20962031 NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774
JBrowse link
G Casp8 caspase 8 multiple interactions ISO [Buthionine Sulfoximine co-treated with arsenic trioxide] results in increased cleavage of CASP8 protein; pyrazolanthrone inhibits the reaction [[Buthionine Sulfoximine co-treated with arsenic trioxide] results in increased cleavage of CASP8 protein] CTD PMID:17145888 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Casp9 caspase 9 multiple interactions
increases activity
ISO 4-amylcinnamoylanthranilic acid inhibits the reaction [Buthionine Sulfoximine results in increased activity of CASP9 protein]; Glutathione inhibits the reaction [Buthionine Sulfoximine results in increased activity of CASP9 protein] CTD PMID:33309544 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cat catalase decreases activity
multiple interactions
EXP
ISO
Buthionine Sulfoximine results in decreased activity of CAT protein
Buthionine Sulfoximine promotes the reaction [Cyclophosphamide results in decreased activity of CAT protein]; CAT inhibits the reaction [Buthionine Sulfoximine results in decreased abundance of Glutathione]; CAT inhibits the reaction [Buthionine Sulfoximine results in increased expression of CD36 protein]; CAT inhibits the reaction [Buthionine Sulfoximine results in increased uptake of malondialdehyde-low density lipoprotein, human]; CD36 mRNA promotes the reaction [CAT inhibits the reaction [Buthionine Sulfoximine results in increased uptake of malondialdehyde-low density lipoprotein, human]]; Plant Extracts inhibits the reaction [Buthionine Sulfoximine promotes the reaction [Cyclophosphamide results in decreased activity of CAT protein]]
CTD PMID:21620807 PMID:21772021 PMID:26187465 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ccl11 C-C motif chemokine ligand 11 multiple interactions ISO [Methimazole co-treated with Buthionine Sulfoximine] results in increased expression of CCL11 mRNA CTD PMID:22407903 PMID:27421576 NCBI chr10:69,434,965...69,439,566
Ensembl chr10:69,434,941...69,439,575
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO
EXP
[Methimazole co-treated with Buthionine Sulfoximine] results in increased expression of CCL2 mRNA
[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased expression of CCL2 mRNA; gadolinium chloride inhibits the reaction [[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased expression of CCL2 mRNA]
CTD PMID:22407903 PMID:26177832 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions ISO Buthionine Sulfoximine promotes the reaction [TNF protein results in increased expression of CCL5 protein]; SB 203580 inhibits the reaction [Buthionine Sulfoximine promotes the reaction [TNF protein results in increased expression of CCL5 protein]] CTD PMID:11167962 NCBI chr10:70,739,764...70,744,303
Ensembl chr10:70,739,800...70,744,315
JBrowse link
G Ccnd1 cyclin D1 multiple interactions EXP Buthionine Sulfoximine inhibits the reaction [Acetylcysteine results in decreased expression of CCND1 protein]; Buthionine Sulfoximine inhibits the reaction [Curcumin results in decreased expression of CCND1 protein] CTD PMID:17602960 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Cd163 CD163 molecule multiple interactions EXP [Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased expression of CD163 mRNA; gadolinium chloride inhibits the reaction [[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased expression of CD163 mRNA] CTD PMID:26177832 NCBI chr 4:156,752,063...156,785,467
Ensembl chr 4:156,752,082...156,785,467
JBrowse link
G Cd36 CD36 molecule increases expression
multiple interactions
ISO Buthionine Sulfoximine results in increased expression of CD36 protein
[pioglitazone co-treated with Buthionine Sulfoximine] results in increased expression of CD36 mRNA; Acetylcysteine inhibits the reaction [Buthionine Sulfoximine results in increased expression of CD36 protein]; CAT inhibits the reaction [Buthionine Sulfoximine results in increased expression of CD36 protein]; CD36 mRNA promotes the reaction [Acetylcysteine inhibits the reaction [Buthionine Sulfoximine results in increased uptake of malondialdehyde-low density lipoprotein, human]]; CD36 mRNA promotes the reaction [Buthionine Sulfoximine results in increased uptake of malondialdehyde-low density lipoprotein, human]; CD36 mRNA promotes the reaction [CAT inhibits the reaction [Buthionine Sulfoximine results in increased uptake of malondialdehyde-low density lipoprotein, human]]; PPARG mRNA promotes the reaction [Tamoxifen inhibits the reaction [Buthionine Sulfoximine results in increased expression of CD36 protein]]; Tamoxifen inhibits the reaction [Buthionine Sulfoximine results in increased expression of CD36 protein]
CTD PMID:26187465 PMID:27358406 PMID:28263783 NCBI chr 4:14,150,309...14,191,498
Ensembl chr 4:14,001,761...14,249,749
JBrowse link
G Cd59 CD59 molecule increases mutagenesis ISO Buthionine Sulfoximine results in increased mutagenesis of CD59 gene CTD PMID:15033018 NCBI chr 3:94,010,481...94,028,660
Ensembl chr 3:94,010,475...94,028,621
JBrowse link
G Cd68 Cd68 molecule multiple interactions EXP [Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased expression of CD68 mRNA; gadolinium chloride inhibits the reaction [[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased expression of CD68 mRNA] CTD PMID:26177832 NCBI chr10:56,268,726...56,270,605
Ensembl chr10:56,268,720...56,270,640
JBrowse link
G Cd86 CD86 molecule increases expression ISO Buthionine Sulfoximine results in increased expression of CD86 protein CTD PMID:20457211 NCBI chr11:67,060,305...67,117,990
Ensembl chr11:67,082,193...67,118,795
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions EXP Buthionine Sulfoximine inhibits the reaction [Acetylcysteine results in increased expression of CDKN1A protein]; Buthionine Sulfoximine inhibits the reaction [Curcumin results in increased expression of CDKN1A protein] CTD PMID:17602960 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B multiple interactions EXP Buthionine Sulfoximine inhibits the reaction [Acetylcysteine results in increased expression of CDKN1B protein]; Buthionine Sulfoximine inhibits the reaction [Curcumin results in increased expression of CDKN1B protein] CTD PMID:17602960 NCBI chr 4:168,689,043...168,694,159
Ensembl chr 4:168,689,163...168,693,964
JBrowse link
G Chek2 checkpoint kinase 2 multiple interactions ISO Buthionine Sulfoximine promotes the reaction [potassium chromate(VI) results in increased expression of CHEK2 protein modified form] CTD PMID:25977998 NCBI chr12:51,845,574...51,878,098
Ensembl chr12:51,845,796...51,877,624
JBrowse link
G Cherp calcium homeostasis endoplasmic reticulum protein increases expression EXP Buthionine Sulfoximine results in increased expression of CHERP protein CTD PMID:23736079 NCBI chr16:19,068,783...19,081,837
Ensembl chr16:19,068,783...19,081,837
JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions EXP Buthionine Sulfoximine inhibits the reaction [Acetylcysteine results in decreased expression of COL1A1 mRNA]; Buthionine Sulfoximine inhibits the reaction [Acetylcysteine results in decreased expression of COL1A1 protein]; Buthionine Sulfoximine inhibits the reaction [Curcumin results in decreased expression of COL1A1 mRNA]; Buthionine Sulfoximine inhibits the reaction [Curcumin results in decreased expression of COL1A1 protein] CTD PMID:17602960 NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789
JBrowse link
G Col1a2 collagen type I alpha 2 chain multiple interactions ISO Buthionine Sulfoximine promotes the reaction [CYP2E1 protein results in increased expression of COL1A2 mRNA] CTD PMID:10498651 NCBI chr 4:31,534,225...31,569,152
Ensembl chr 4:31,534,225...31,569,151
JBrowse link
G Col5a3 collagen type V alpha 3 chain decreases expression ISO Buthionine Sulfoximine results in decreased expression of COL5A3 mRNA CTD PMID:15878706 NCBI chr 8:21,786,324...21,831,751
Ensembl chr 8:21,786,324...21,831,668
JBrowse link
G Cox4i1 cytochrome c oxidase subunit 4i1 increases expression ISO Buthionine Sulfoximine results in increased expression of COX4I1 mRNA CTD PMID:15878706 NCBI chr19:54,245,958...54,252,198
Ensembl chr19:54,245,950...54,252,225
JBrowse link
G Cse1l chromosome segregation 1 like increases expression EXP Buthionine Sulfoximine results in increased expression of CSE1L protein CTD PMID:23736079 NCBI chr 3:163,664,074...163,702,074
Ensembl chr 3:163,664,136...163,702,060
JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 multiple interactions EXP [Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased expression of CXCL1 mRNA; gadolinium chloride inhibits the reaction [[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased expression of CXCL1 mRNA] CTD PMID:26177832 NCBI chr14:18,743,678...18,745,457
Ensembl chr14:18,743,685...18,745,457
JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 decreases expression ISO Buthionine Sulfoximine results in decreased expression of CXCL12 mRNA CTD PMID:15878706 NCBI chr 4:149,261,044...149,273,891
Ensembl chr 4:149,261,044...149,273,891
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 multiple interactions ISO
EXP
[Methimazole co-treated with Buthionine Sulfoximine] results in increased expression of CXCL2 mRNA; [Phenytoin co-treated with Buthionine Sulfoximine] results in increased expression of CXCL2 mRNA; [pioglitazone co-treated with Buthionine Sulfoximine] results in increased expression of CXCL2 mRNA; Alprostadil inhibits the reaction [[Phenytoin co-treated with Buthionine Sulfoximine] results in increased expression of CXCL2 mRNA]
[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased expression of CXCL2 mRNA; gadolinium chloride inhibits the reaction [[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased expression of CXCL2 mRNA]
CTD PMID:23986454 PMID:26177832 PMID:27421576 PMID:28263783 NCBI chr14:18,731,346...18,733,391
Ensembl chr14:18,731,378...18,733,391
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 multiple interactions ISO Buthionine Sulfoximine promotes the reaction [Tobacco Smoke Pollution results in increased secretion of and results in increased expression of CXCL1 protein] CTD PMID:26149495 NCBI chr14:18,820,168...18,839,659
Ensembl chr14:18,820,168...18,839,595
JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 decreases expression ISO Buthionine Sulfoximine results in decreased expression of CXCR4 mRNA CTD PMID:15878706 NCBI chr13:45,314,952...45,318,856
Ensembl chr13:45,314,933...45,318,878
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
decreases activity
increases activity
ISO
EXP
Buthionine Sulfoximine affects the reaction [Curcumin affects the reaction [6-formylindolo(3,2-b)carbazole results in increased activity of CYP1A1 protein]]; Buthionine Sulfoximine inhibits the reaction [6-formylindolo(3,2-b)carbazole results in increased expression of CYP1A1 mRNA]; Buthionine Sulfoximine inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]; Buthionine Sulfoximine promotes the reaction [2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [6-formylindolo(3,2-b)carbazole results in increased activity of CYP1A1 protein]]; Buthionine Sulfoximine promotes the reaction [sodium arsenite inhibits the reaction [6-formylindolo(3,2-b)carbazole results in increased expression of CYP1A1 mRNA]]; Buthionine Sulfoximine promotes the reaction [sodium arsenite results in increased expression of CYP1A1 mRNA]
Buthionine Sulfoximine results in decreased activity of CYP1A1 protein
Buthionine Sulfoximine results in increased activity of CYP1A1 protein
[Buthionine Sulfoximine co-treated with 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide] inhibits the reaction [6-formylindolo(3,2-b)carbazole results in increased activity of CYP1A1 protein]; [Buthionine Sulfoximine co-treated with Cadmium Chloride] results in increased expression of CYP1A1 mRNA; [Buthionine Sulfoximine results in decreased abundance of Glutathione] which results in increased expression of CYP1A1 mRNA; Buthionine Sulfoximine inhibits the reaction [6-formylindolo(3,2-b)carbazole results in increased activity of CYP1A1 protein]; Buthionine Sulfoximine promotes the reaction [andrographolide affects the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]]; Buthionine Sulfoximine promotes the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]; Buthionine Sulfoximine promotes the reaction [Cadmium Chloride promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]]; Buthionine Sulfoximine promotes the reaction [chromium trioxide promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]]; Buthionine Sulfoximine promotes the reaction [chromium trioxide results in increased expression of CYP1A1 mRNA]; Buthionine Sulfoximine promotes the reaction [Copper inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 protein]]; Buthionine Sulfoximine promotes the reaction [Lead inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 protein]]; Buthionine Sulfoximine promotes the reaction [Lead results in increased expression of CYP1A1 mRNA]; Buthionine Sulfoximine promotes the reaction [Mercury inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 protein]]; Buthionine Sulfoximine promotes the reaction [sodium arsenite promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]]; Buthionine Sulfoximine promotes the reaction [sodium arsenite results in increased expression of CYP1A1 mRNA]; Buthionine Sulfoximine promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]
Buthionine Sulfoximine inhibits the reaction [Methylcholanthrene results in increased activity of CYP1A1 protein]; Buthionine Sulfoximine inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]
CTD PMID:9756946 PMID:16274885 PMID:16906435 PMID:18078826 PMID:19033395 PMID:21094198 PMID:26535918 PMID:27041069 PMID:29975444 PMID:30793600 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 increases response to substance
multiple interactions
ISO CYP2E1 protein results in increased susceptibility to Buthionine Sulfoximine; CYP2E1 results in increased susceptibility to Buthionine Sulfoximine
Buthionine Sulfoximine promotes the reaction [[CYP2E1 protein co-treated with Vitamin K 3] results in increased expression of KLF6 protein]; Buthionine Sulfoximine promotes the reaction [CYP2E1 protein results in increased expression of COL1A2 mRNA]; Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin promotes the reaction [CYP2E1 protein results in increased susceptibility to Buthionine Sulfoximine]; Zinc Sulfate inhibits the reaction [CYP2E1 results in increased susceptibility to Buthionine Sulfoximine]
CTD PMID:10498651 PMID:12086689 PMID:12566070 PMID:22486562 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Cyp3a62 cytochrome P450, family 3, subfamily a, polypeptide 62 multiple interactions ISO [CYP3A4 protein co-treated with Buthionine Sulfoximine] results in decreased abundance of Glutathione; Buthionine Sulfoximine promotes the reaction [[CYP3A4 protein co-treated with neferine] results in decreased abundance of Glutathione]; neferine promotes the reaction [[CYP3A4 protein co-treated with Buthionine Sulfoximine] results in decreased abundance of Glutathione] CTD PMID:25451576 NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397
JBrowse link
G Dab1 DAB adaptor protein 1 decreases expression ISO Buthionine Sulfoximine results in decreased expression of DAB1 mRNA CTD PMID:15878706 NCBI chr 5:123,154,360...124,279,170
Ensembl chr 5:123,905,166...124,280,115
JBrowse link
G Dars1 aspartyl-tRNA synthetase 1 increases expression EXP Buthionine Sulfoximine results in increased expression of DARS protein CTD PMID:23736079 NCBI chr13:45,074,067...45,127,815
Ensembl chr13:45,074,072...45,127,815
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions ISO Buthionine Sulfoximine promotes the reaction [Curcumin results in increased expression of DDIT3 mRNA]; Buthionine Sulfoximine promotes the reaction [Curcumin results in increased expression of DDIT3 protein]; Buthionine Sulfoximine promotes the reaction [pterostilbene results in increased expression of DDIT3 protein] CTD PMID:17171638 PMID:25341683 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
JBrowse link
G Dgat2 diacylglycerol O-acyltransferase 2 decreases expression EXP Buthionine Sulfoximine results in decreased expression of DGAT2 mRNA CTD PMID:20482862 NCBI chr 1:164,113,459...164,143,818
Ensembl chr 1:164,113,459...164,143,818
JBrowse link
G Dio2 iodothyronine deiodinase 2 multiple interactions EXP Buthionine Sulfoximine inhibits the reaction [Colforsin results in increased activity of DIO2 protein] CTD PMID:18420745 NCBI chr 6:114,475,156...114,489,443
Ensembl chr 6:114,476,142...114,476,723
JBrowse link
G Dio3 iodothyronine deiodinase 3 increases activity EXP Buthionine Sulfoximine results in increased activity of DIO3 protein CTD PMID:18420745 NCBI chr 6:134,627,278...134,629,139
Ensembl chr 6:134,627,278...134,629,138
JBrowse link
G Dld dihydrolipoamide dehydrogenase increases expression EXP Buthionine Sulfoximine results in increased expression of DLD protein CTD PMID:23736079 NCBI chr 6:50,597,677...50,618,694
Ensembl chr 6:50,597,677...50,618,694
JBrowse link
G Ech1 enoyl-CoA hydratase 1 increases expression ISO Buthionine Sulfoximine results in increased expression of ECH1 mRNA CTD PMID:15878706 NCBI chr 1:87,009,798...87,015,996
Ensembl chr 1:87,009,730...87,016,005
JBrowse link
G Eef1a1 eukaryotic translation elongation factor 1 alpha 1 increases expression ISO Buthionine Sulfoximine results in increased expression of EEF1A1 mRNA CTD PMID:15878706 NCBI chr 8:85,838,594...85,841,816
Ensembl chr 8:85,838,869...85,840,818
JBrowse link
G Eef1b2 eukaryotic translation elongation factor 1 beta 2 increases expression ISO Buthionine Sulfoximine results in increased expression of EEF1B2 mRNA CTD PMID:15878706 NCBI chr 9:69,953,440...69,956,158
Ensembl chr 9:69,953,440...69,956,160
JBrowse link
G Egr1 early growth response 1 multiple interactions EXP Buthionine Sulfoximine promotes the reaction [Cadmium Chloride results in increased expression of EGR1 mRNA] CTD PMID:19010381 NCBI chr18:27,657,903...27,660,101
Ensembl chr18:27,657,628...27,661,429
JBrowse link
G Eif1a eukaryotic translation initiation factor 1A decreases expression ISO Buthionine Sulfoximine results in decreased expression of EIF1A mRNA CTD PMID:15878706 NCBI chr18:40,586,315...40,598,661
Ensembl chr18:40,586,315...40,597,671
JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 multiple interactions ISO Buthionine Sulfoximine promotes the reaction [pterostilbene results in increased phosphorylation of EIF2AK3 protein] CTD PMID:25341683 NCBI chr 4:98,648,513...98,709,695
Ensembl chr 4:98,648,545...98,709,694
JBrowse link
G Eif2b4 eukaryotic translation initiation factor 2B subunit delta decreases expression ISO Buthionine Sulfoximine results in decreased expression of EIF2B4 mRNA CTD PMID:15878706 NCBI chr 6:26,546,917...26,552,474
Ensembl chr 6:26,546,924...26,552,430
JBrowse link
G Eif3g eukaryotic translation initiation factor 3, subunit G decreases expression ISO Buthionine Sulfoximine results in decreased expression of EIF3G mRNA CTD PMID:15878706 NCBI chr 8:21,911,632...21,915,664
Ensembl chr 8:21,911,625...21,915,716
JBrowse link
G Esyt1 extended synaptotagmin 1 decreases expression ISO Buthionine Sulfoximine results in decreased expression of ESYT1 mRNA CTD PMID:15878706 NCBI chr 7:2,924,216...2,941,213
Ensembl chr 7:2,924,603...2,941,122
JBrowse link
G Etf1 eukaryotic translation termination factor 1 increases expression ISO Buthionine Sulfoximine results in increased expression of ETF1 mRNA CTD PMID:15707499 NCBI chr18:27,698,693...27,725,694
Ensembl chr18:27,698,695...27,725,694
JBrowse link
G Ezh1 enhancer of zeste 1 polycomb repressive complex 2 subunit decreases expression ISO Buthionine Sulfoximine results in decreased expression of EZH1 mRNA CTD PMID:15878706 NCBI chr10:89,104,026...89,139,978
Ensembl chr10:89,104,027...89,130,339
JBrowse link
G Fas Fas cell surface death receptor multiple interactions EXP Buthionine Sulfoximine inhibits the reaction [Copper deficiency results in increased expression of FAS mRNA] CTD PMID:9227460 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790
JBrowse link
G Faslg Fas ligand multiple interactions ISO [Phenytoin co-treated with Buthionine Sulfoximine] results in decreased expression of FASL mRNA CTD PMID:23986454 NCBI chr13:79,696,811...79,717,581
Ensembl chr13:79,698,445...79,705,705
JBrowse link
G Fkbp5 FKBP prolyl isomerase 5 increases expression EXP Buthionine Sulfoximine results in increased expression of FKBP5 protein CTD PMID:23736079 NCBI chr20:7,976,704...8,097,290
Ensembl chr20:7,976,713...8,019,020
JBrowse link
G Flt1 Fms related receptor tyrosine kinase 1 increases expression ISO Buthionine Sulfoximine results in increased expression of FLT1 mRNA CTD PMID:15878706 NCBI chr12:9,033,993...9,205,886
Ensembl chr12:9,034,308...9,205,905
JBrowse link
G Fmo3 flavin containing dimethylaniline monoxygenase 3 multiple interactions ISO Buthionine Sulfoximine inhibits the reaction [FMO3 protein results in increased susceptibility to Thiourea] CTD PMID:12093470 NCBI chr13:80,837,418...80,856,214
Ensembl chr13:80,837,420...80,862,963
JBrowse link
G Fn1 fibronectin 1 multiple interactions EXP [Buthionine Sulfoximine results in decreased abundance of Glutathione] promotes the reaction [manganese chloride results in increased expression of and results in increased secretion of FN1 protein] CTD PMID:19524604 NCBI chr 9:78,900,111...78,969,018
Ensembl chr 9:78,900,103...78,969,078
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression
ISO
EXP
Buthionine Sulfoximine inhibits the reaction [Sodium Selenite results in increased expression of FOS mRNA]; Buthionine Sulfoximine promotes the reaction [Asbestos, Crocidolite results in increased expression of FOS mRNA]; Glucosamine analog inhibits the reaction [Buthionine Sulfoximine results in increased expression of FOS mRNA] CTD PMID:7743507 PMID:15520183 PMID:18449455 PMID:21825963 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Fosl1 FOS like 1, AP-1 transcription factor subunit multiple interactions ISO
EXP
Buthionine Sulfoximine promotes the reaction [Asbestos, Crocidolite results in increased expression of FOSL1 mRNA]
Buthionine Sulfoximine promotes the reaction [Cadmium Chloride results in increased expression of FOSL1 mRNA]
CTD PMID:15520183 PMID:19010381 NCBI chr 1:220,826,560...220,835,066
Ensembl chr 1:220,826,560...220,835,066
JBrowse link
G Foxp3 forkhead box P3 multiple interactions ISO
EXP
[Phenytoin co-treated with Buthionine Sulfoximine] results in decreased expression of FOXP3 mRNA
[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased expression of FOXP3 mRNA
CTD PMID:23986454 PMID:26177832 NCBI chr  X:15,753,175...15,768,648
Ensembl chr  X:15,753,175...15,768,522
JBrowse link
G Fth1 ferritin heavy chain 1 multiple interactions
increases expression
ISO Buthionine Sulfoximine promotes the reaction [3-O-caffeoyl-1-methylquinic acid results in increased expression of FTH1 mRNA]
Buthionine Sulfoximine results in increased expression of FTH1 mRNA
CTD PMID:15878706 PMID:16631525 NCBI chr 1:226,030,940...226,033,228
Ensembl chr 1:226,030,938...226,033,228
JBrowse link
G G6pd glucose-6-phosphate dehydrogenase increases expression EXP Buthionine Sulfoximine results in increased expression of G6PD mRNA CTD PMID:12717738 NCBI chr  X:156,274,800...156,293,935
Ensembl chr  X:156,274,800...156,293,926
JBrowse link
G Gapdh glyceraldehyde-3-phosphate dehydrogenase multiple interactions
increases expression
ISO [Buthionine Sulfoximine results in decreased abundance of Glutathione] promotes the reaction [1,2-naphthoquinone binds to GAPDH protein]; [Buthionine Sulfoximine results in decreased abundance of Glutathione] promotes the reaction [1,2-naphthoquinone results in decreased activity of GAPDH protein]
Buthionine Sulfoximine results in increased expression of GAPDH mRNA
CTD PMID:15878706 PMID:21827172 NCBI chr 4:157,676,336...157,680,322
Ensembl chr 4:157,676,595...157,679,962
JBrowse link
G Gata3 GATA binding protein 3 multiple interactions
decreases expression
ISO
EXP
[Methimazole co-treated with Buthionine Sulfoximine] results in increased expression of GATA3 mRNA; [Phenytoin co-treated with Buthionine Sulfoximine] results in decreased expression of GATA3 mRNA
Buthionine Sulfoximine results in decreased expression of GATA3 mRNA
CTD PMID:22407903 PMID:23986454 PMID:26177832 PMID:27421576 NCBI chr17:72,419,752...72,452,043
Ensembl chr17:72,429,618...72,450,681
JBrowse link
G Gc GC, vitamin D binding protein multiple interactions EXP [Aflatoxin B1 co-treated with Buthionine Sulfoximine] results in increased expression of GC mRNA CTD PMID:23288050 NCBI chr14:20,267,023...20,302,577
Ensembl chr14:20,266,891...20,302,581
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases activity
increases expression
multiple interactions
decreases activity
ISO
EXP
Buthionine Sulfoximine results in increased activity of GCLC protein
Buthionine Sulfoximine results in increased expression of GCLC mRNA
[Buthionine Sulfoximine results in decreased activity of GCLC protein] inhibits the reaction [indenoindole results in increased abundance of Glutathione]; [Buthionine Sulfoximine results in decreased activity of GCLC protein] which results in decreased abundance of Glutathione; [Thiabendazole co-treated with Buthionine Sulfoximine] results in increased activity of GCLC protein; Buthionine Sulfoximine inhibits the reaction [GCLC protein results in decreased susceptibility to naphthalene]; Buthionine Sulfoximine inhibits the reaction [Hypochlorous Acid results in increased expression of GCLC mRNA]; Buthionine Sulfoximine inhibits the reaction [naphthalene results in increased activity of GCLC protein]
Buthionine Sulfoximine inhibits the reaction [[Lithocholic Acid results in increased expression of GCLC protein] which results in increased abundance of Glutathione]; Buthionine Sulfoximine inhibits the reaction [GCLC results in decreased susceptibility to Cadmium Chloride]
[Buthionine Sulfoximine co-treated with Carmustine] results in decreased activity of GCLC protein; [Buthionine Sulfoximine results in decreased activity of [GCLC protein binds to GCLM protein]] inhibits the reaction [chrysin inhibits the reaction [tert-Butylhydroperoxide results in increased chemical synthesis of Reactive Oxygen Species]]; [Carmustine co-treated with Buthionine Sulfoximine] results in decreased activity of GCLC protein; Buthionine Sulfoximine inhibits the reaction [decamethrin results in increased expression of GCLC mRNA]; Buthionine Sulfoximine inhibits the reaction [GCLC protein results in increased chemical synthesis of gamma-glutamylcysteine]; Buthionine Sulfoximine inhibits the reaction [Microcystins analog results in increased expression of GCLC mRNA]
CTD PMID:7955076 PMID:10900227 PMID:10915739 PMID:10978506 PMID:11019651 PMID:12433058 PMID:12805647 PMID:12967637 PMID:15115889 PMID:15707499 PMID:16288907 PMID:17724089 PMID:17980396 PMID:18449455 PMID:18556457 PMID:22864849 PMID:23585199 PMID:24964298 NCBI chr 8:85,059,051...85,097,471
Ensembl chr 8:85,059,051...85,097,468
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression
multiple interactions
EXP
ISO
Buthionine Sulfoximine results in increased expression of GCLM mRNA
Buthionine Sulfoximine inhibits the reaction [[Lithocholic Acid results in increased expression of GCLM protein] which results in increased abundance of Glutathione]
[Buthionine Sulfoximine results in decreased activity of [GCLC protein binds to GCLM protein]] inhibits the reaction [chrysin inhibits the reaction [tert-Butylhydroperoxide results in increased chemical synthesis of Reactive Oxygen Species]]
CTD PMID:10978506 PMID:17724089 PMID:19010381 PMID:22864849 NCBI chr 2:225,827,504...225,847,876
Ensembl chr 2:225,827,504...225,847,874
JBrowse link
G Gdi2 GDP dissociation inhibitor 2 decreases expression ISO Buthionine Sulfoximine results in decreased expression of GDI2 mRNA CTD PMID:15878706 NCBI chr17:70,299,177...70,325,864
Ensembl chr17:70,299,183...70,325,855
JBrowse link
G Gmfb glia maturation factor, beta increases response to substance ISO GMFB protein results in increased susceptibility to Buthionine Sulfoximine CTD PMID:12791701 NCBI chr15:23,597,846...23,611,541
Ensembl chr15:23,601,368...23,606,634
JBrowse link
G Gpi glucose-6-phosphate isomerase increases expression ISO Buthionine Sulfoximine results in increased expression of GPI1 mRNA CTD PMID:15878706 NCBI chr 1:90,063,411...90,091,287
Ensembl chr 1:90,063,411...90,091,287
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions EXP
ISO
[allyl sulfide co-treated with dimethyl-4,4'-dimethoxy-5,6,5',6'-dimethylene dioxybiphenyl-2,2'-dicarboxylate] inhibits the reaction [[Carbon Tetrachloride co-treated with Buthionine Sulfoximine] results in increased activity of GPT protein]; [Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased expression of GPT protein; [Carbon Tetrachloride co-treated with Buthionine Sulfoximine] results in increased expression of and results in increased activity of GPT protein; gadolinium chloride inhibits the reaction [[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased expression of GPT protein]; Ursodeoxycholic Acid inhibits the reaction [[Carbon Tetrachloride co-treated with Buthionine Sulfoximine] results in increased activity of GPT protein]
[Buthionine Sulfoximine co-treated with Lovastatin co-treated with Gemfibrozil] results in increased expression of GPT protein; [Methimazole co-treated with Buthionine Sulfoximine] results in increased expression of GPT protein; Buthionine Sulfoximine promotes the reaction [[Atorvastatin co-treated with Ciprofloxacin] results in increased expression of GPT protein]
CTD PMID:15950962 PMID:26177832 PMID:27421576 PMID:29679711 PMID:30853469 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931
JBrowse link
G Gpx1 glutathione peroxidase 1 affects activity
multiple interactions
ISO
EXP
Buthionine Sulfoximine affects the activity of GPX1 protein
Buthionine Sulfoximine promotes the reaction [Microcystins analog results in increased expression of GPX1 mRNA]
Buthionine Sulfoximine promotes the reaction [pterostilbene results in increased expression of GPX1 mRNA]
CTD PMID:15707499 PMID:24964298 PMID:25341683 NCBI chr 8:117,117,430...117,118,528
Ensembl chr 8:117,117,430...117,118,522
JBrowse link
G Gpx2 glutathione peroxidase 2 increases expression ISO Buthionine Sulfoximine results in increased expression of GPX2 mRNA CTD PMID:15878706 NCBI chr 6:99,839,960...99,843,245
Ensembl chr 6:99,839,960...99,843,245
JBrowse link
G Gpx3 glutathione peroxidase 3 increases expression ISO Buthionine Sulfoximine results in increased expression of GPX3 mRNA CTD PMID:15878706 NCBI chr10:40,247,436...40,255,423
Ensembl chr10:40,247,436...40,255,422
JBrowse link
G Grb2 growth factor receptor bound protein 2 decreases expression ISO Buthionine Sulfoximine results in decreased expression of GRB2 mRNA CTD PMID:15878706 NCBI chr10:104,193,953...104,263,071
Ensembl chr10:104,193,955...104,263,071
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta decreases phosphorylation ISO Buthionine Sulfoximine results in decreased phosphorylation of GSK3B protein CTD PMID:18552690 NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268
JBrowse link
G Gsn gelsolin increases expression ISO Buthionine Sulfoximine results in increased expression of GSN mRNA CTD PMID:15878706 NCBI chr 3:14,456,106...14,508,922
Ensembl chr 3:14,467,330...14,508,911
JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions ISO
EXP
Buthionine Sulfoximine inhibits the reaction [schizandrin B results in increased activity of GSR protein]; Buthionine Sulfoximine promotes the reaction [Cyclophosphamide results in decreased activity of GSR protein]; Plant Extracts inhibits the reaction [Buthionine Sulfoximine promotes the reaction [Cyclophosphamide results in decreased activity of GSR protein]]
[Buthionine Sulfoximine co-treated with Carmustine] results in decreased activity of GSR protein; [Carmustine co-treated with Buthionine Sulfoximine] results in decreased activity of GSR protein; [cyanoginosin LR co-treated with Buthionine Sulfoximine] results in increased activity of GSR protein; Buthionine Sulfoximine inhibits the reaction [Microcystins analog results in decreased expression of GSR mRNA]; Buthionine Sulfoximine inhibits the reaction [schizandrin B results in increased activity of GSR protein]; Buthionine Sulfoximine promotes the reaction [Arsenic Trioxide results in increased expression of GSR mRNA]
CTD PMID:12967637 PMID:16288907 PMID:17119269 PMID:21772021 PMID:24634002 PMID:24964298 PMID:25410294 NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361
JBrowse link
G Gss glutathione synthetase decreases activity
increases expression
EXP Buthionine Sulfoximine results in decreased activity of GSS protein
Buthionine Sulfoximine results in increased expression of GSS mRNA
CTD PMID:10904027 PMID:10978506 NCBI chr 3:151,076,254...151,106,557
Ensembl chr 3:151,076,254...151,106,557
JBrowse link
G Gsta1 glutathione S-transferase alpha 1 multiple interactions EXP Buthionine Sulfoximine promotes the reaction [Cadmium Chloride results in increased expression of GSTA1 mRNA] CTD PMID:9152014 NCBI chr 9:27,366,404...27,381,004
Ensembl chr 9:27,368,272...27,452,902
JBrowse link
G Gstm1 glutathione S-transferase mu 1 increases expression ISO Buthionine Sulfoximine results in increased expression of GSTM1 mRNA CTD PMID:15878706 NCBI chr 2:210,803,869...210,809,461
Ensembl chr 2:210,803,869...210,809,306
JBrowse link
G Gstm2 glutathione S-transferase mu 2 increases expression ISO Buthionine Sulfoximine results in increased expression of GSTM2 mRNA CTD PMID:15878706 NCBI chr 2:210,778,041...210,782,807
Ensembl chr 2:210,720,704...210,782,856
JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions ISO
EXP
Buthionine Sulfoximine inhibits the reaction [GSTP1 results in decreased susceptibility to Benzo(a)pyrene]
Buthionine Sulfoximine inhibits the reaction [Microcystins analog results in increased expression of GSTP1 mRNA]
CTD PMID:19330882 PMID:24964298 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
G Hadh hydroxyacyl-CoA dehydrogenase increases expression ISO Buthionine Sulfoximine results in increased expression of HADH mRNA CTD PMID:15878706 NCBI chr 2:236,353,445...236,395,067
Ensembl chr 2:236,353,445...236,395,067
JBrowse link
G Hbs1l HBS1-like translational GTPase decreases expression ISO Buthionine Sulfoximine results in decreased expression of HBS1L mRNA CTD PMID:15878706 NCBI chr 1:16,819,170...16,896,234
Ensembl chr 1:16,819,170...16,896,219
JBrowse link
G Hdgf heparin binding growth factor increases expression ISO Buthionine Sulfoximine results in increased expression of HDGF mRNA CTD PMID:15878706 NCBI chr 2:187,274,898...187,284,670
Ensembl chr 2:187,275,120...187,284,281
JBrowse link
G Hgf hepatocyte growth factor increases expression EXP Buthionine Sulfoximine results in increased expression of HGF protein CTD PMID:9763232 NCBI chr 4:15,435,460...15,505,377
Ensembl chr 4:15,433,295...15,505,362
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions
increases activity
ISO
EXP
Buthionine Sulfoximine promotes the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of HIF1A protein]; Buthionine Sulfoximine promotes the reaction [sodium arsenite results in increased expression of HIF1A protein]
Buthionine Sulfoximine results in increased activity of HIF1A protein
CTD PMID:11641398 PMID:11841787 PMID:17658243 NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052
JBrowse link
G Hmgb1 high mobility group box 1 multiple interactions ISO
EXP
[Phenytoin co-treated with Buthionine Sulfoximine] results in increased secretion of HMGB1 protein
[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased secretion of HMGB1 protein; gadolinium chloride inhibits the reaction [[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased secretion of HMGB1 protein]
CTD PMID:23986454 PMID:26177832 NCBI chr12:7,082,529...7,090,246
Ensembl chr16:37,500,017...37,502,237
JBrowse link
G Hmgb2 high mobility group box 2 increases expression ISO Buthionine Sulfoximine results in increased expression of HMGB2 mRNA CTD PMID:15707499 NCBI chr16:36,077,615...36,080,191
Ensembl chr16:36,077,617...36,080,191
Ensembl chr11:36,077,617...36,080,191
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression
ISO
EXP
1-aminobenzotriazole inhibits the reaction [[Acetaminophen co-treated with Buthionine Sulfoximine] results in increased expression of HMOX1 mRNA]; 1-aminobenzotriazole inhibits the reaction [[Butylated Hydroxyanisole co-treated with Buthionine Sulfoximine] results in increased expression of HMOX1 mRNA]; 1-aminobenzotriazole inhibits the reaction [[Diclofenac co-treated with Buthionine Sulfoximine] results in increased expression of HMOX1 mRNA]; 1-aminobenzotriazole inhibits the reaction [[Ticlopidine co-treated with Buthionine Sulfoximine] results in increased expression of HMOX1 mRNA]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[Buthionine Sulfoximine results in decreased abundance of Glutathione] which results in increased expression of HMOX1 mRNA]; [2-tert-butylhydroquinone co-treated with Buthionine Sulfoximine] results in increased expression of HMOX1 mRNA; [Buthionine Sulfoximine co-treated with Ascorbic Acid] promotes the reaction [Copper Sulfate results in increased expression of HMOX1 mRNA]; [Buthionine Sulfoximine co-treated with Dehydroascorbic Acid] promotes the reaction [cupric oxide results in increased expression of HMOX1 mRNA]; [Buthionine Sulfoximine results in decreased abundance of Glutathione] which results in increased expression of HMOX1 mRNA; [monocrystalline iron oxide nanoparticle co-treated with Buthionine Sulfoximine co-treated with Dehydroascorbic Acid] results in increased expression of HMOX1 mRNA; [monocrystalline iron oxide nanoparticle co-treated with Buthionine Sulfoximine] results in increased expression of HMOX1 mRNA; Buthionine Sulfoximine promotes the reaction [3-O-caffeoyl-1-methylquinic acid results in increased expression of HMOX1 mRNA]; Buthionine Sulfoximine promotes the reaction [Acetaminophen results in increased expression of HMOX1 mRNA]; Buthionine Sulfoximine promotes the reaction [Butylated Hydroxyanisole results in increased expression of HMOX1 mRNA]; Buthionine Sulfoximine promotes the reaction [Cadmium Chloride results in increased expression of HMOX1 protein]; Buthionine Sulfoximine promotes the reaction [Copper Sulfate results in increased expression of HMOX1 mRNA]; Buthionine Sulfoximine promotes the reaction [cupric oxide results in increased expression of HMOX1 mRNA]; Buthionine Sulfoximine promotes the reaction [Diclofenac results in increased expression of HMOX1 mRNA]; Buthionine Sulfoximine promotes the reaction [Potassium Dichromate results in increased expression of HMOX1 mRNA]; Buthionine Sulfoximine promotes the reaction [Raloxifene Hydrochloride results in increased expression of HMOX1 mRNA]; Buthionine Sulfoximine promotes the reaction [Ticlopidine results in increased expression of HMOX1 mRNA]; TNF protein inhibits the reaction [[Buthionine Sulfoximine results in decreased abundance of Glutathione] which results in increased expression of HMOX1 mRNA]
Buthionine Sulfoximine results in increased expression of HMOX1 protein
Buthionine Sulfoximine results in increased expression of HMOX1 mRNA
[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased expression of HMOX1 mRNA; Buthionine Sulfoximine inhibits the reaction [decamethrin results in increased expression of HMOX1 mRNA]; Buthionine Sulfoximine promotes the reaction [Cadmium Chloride results in increased expression of HMOX1 mRNA]; Buthionine Sulfoximine promotes the reaction [Cadmium Chloride results in increased expression of HMOX1 protein]
[Buthionine Sulfoximine co-treated with Gefitinib] results in increased expression of HMOX1 mRNA; [Buthionine Sulfoximine results in decreased abundance of Glutathione] which results in increased expression of HMOX1 mRNA; [Pioglitazone co-treated with Buthionine Sulfoximine] results in increased expression of HMOX1 mRNA; Buthionine Sulfoximine promotes the reaction [[Cadmium Chloride co-treated with Tetrachlorodibenzodioxin] results in increased expression of HMOX1 mRNA]; Buthionine Sulfoximine promotes the reaction [[chromium trioxide co-treated with Tetrachlorodibenzodioxin] results in increased expression of HMOX1 mRNA]; Buthionine Sulfoximine promotes the reaction [[sodium arsenite co-treated with Tetrachlorodibenzodioxin] results in increased expression of HMOX1 mRNA]; Buthionine Sulfoximine promotes the reaction [Cadmium Chloride results in increased expression of HMOX1 mRNA]; Buthionine Sulfoximine promotes the reaction [chromium trioxide results in increased expression of HMOX1 mRNA]; Buthionine Sulfoximine promotes the reaction [Diclofenac results in increased expression of HMOX1 protein]; Buthionine Sulfoximine promotes the reaction [Lead results in increased expression of HMOX1 mRNA]; Buthionine Sulfoximine promotes the reaction [sodium arsenite results in increased expression of HMOX1 mRNA]; Diclofenac promotes the reaction [Buthionine Sulfoximine results in increased expression of HMOX1 protein]
CTD PMID:7626009 PMID:9152014 PMID:11841787 PMID:12763371 PMID:16274885 PMID:16631525 PMID:18078826 PMID:18227147 PMID:18332044 PMID:19683516 PMID:20888885 PMID:21971136 PMID:22659318 PMID:23585199 PMID:23939143 PMID:24401988 PMID:26177832 PMID:28263783 PMID:30497689 PMID:32741899 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hmox2 heme oxygenase 2 affects response to substance ISO HMOX2 affects the susceptibility to Buthionine Sulfoximine CTD PMID:16181104 NCBI chr10:10,990,034...11,035,493
Ensembl chr10:10,990,034...11,035,484
JBrowse link
G Hnrnpm heterogeneous nuclear ribonucleoprotein M increases expression EXP Buthionine Sulfoximine results in increased expression of HNRNPM protein CTD PMID:23736079 NCBI chr 7:18,516,253...18,554,536
Ensembl chr 7:18,516,512...18,554,227
JBrowse link
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 increases expression EXP Buthionine Sulfoximine results in increased expression of HSP90AA1 protein CTD PMID:23736079 NCBI chr 6:135,107,262...135,112,793
Ensembl chr 6:135,107,271...135,112,775
Ensembl chr 6:135,107,271...135,112,775
JBrowse link
G Hsp90ab1 heat shock protein 90 alpha family class B member 1 increases expression ISO Buthionine Sulfoximine results in increased expression of HSP90AB1 mRNA CTD PMID:15707499 NCBI chr 9:17,817,791...17,823,163
Ensembl chr 9:17,817,721...17,823,243
JBrowse link
G Hspa4 heat shock protein family A (Hsp70) member 4 increases expression EXP Buthionine Sulfoximine results in increased expression of HSPA4 protein CTD PMID:23736079 NCBI chr10:38,601,624...38,642,397
Ensembl chr10:38,601,624...38,642,397
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions ISO Buthionine Sulfoximine promotes the reaction [pterostilbene results in increased expression of HSPA5 protein] CTD PMID:25341683 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
JBrowse link
G Hspa8 heat shock protein family A (Hsp70) member 8 increases expression ISO
EXP
Buthionine Sulfoximine results in increased expression of HSPA8 mRNA CTD PMID:7626009 PMID:15707499 NCBI chr 8:44,989,401...44,993,261
Ensembl chr 8:44,990,014...44,993,179
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions
increases expression
ISO 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [Tetradecanoylphorbol Acetate promotes the reaction [Buthionine Sulfoximine results in increased expression of ICAM1 protein]]; Buthionine Sulfoximine inhibits the reaction [carnosol inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]]; Buthionine Sulfoximine inhibits the reaction [cinnamic aldehyde inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]]; Tetradecanoylphorbol Acetate promotes the reaction [Buthionine Sulfoximine results in increased expression of ICAM1 protein]
[zomepirac co-treated with Buthionine Sulfoximine co-treated with tri-o-cresyl phosphate] results in increased expression of ICAM1 mRNA
CTD PMID:11164475 PMID:20116392 PMID:20351055 PMID:29154782 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Igfbp1 insulin-like growth factor binding protein 1 multiple interactions EXP Buthionine Sulfoximine inhibits the reaction [INS1 protein results in decreased expression of IGFBP1 mRNA] CTD PMID:17213664 NCBI chr14:87,448,716...87,453,783
Ensembl chr14:87,448,692...87,453,785
JBrowse link
G Il10 interleukin 10 multiple interactions ISO
EXP
Buthionine Sulfoximine inhibits the reaction [Lipopolysaccharides results in increased secretion of IL10 protein]; Buthionine Sulfoximine promotes the reaction [methyldithiocarbamate promotes the reaction [Lipopolysaccharides results in increased secretion of IL10 protein]]
[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased expression of IL10 mRNA; gadolinium chloride inhibits the reaction [[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased expression of IL10 mRNA]
CTD PMID:19339665 PMID:26177832 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il12b interleukin 12B multiple interactions ISO Buthionine Sulfoximine inhibits the reaction [Lipopolysaccharides results in increased expression of IL12B protein]; Buthionine Sulfoximine inhibits the reaction [methyldithiocarbamate inhibits the reaction [Lipopolysaccharides results in increased secretion of IL12B protein]] CTD PMID:12688424 PMID:19339665 NCBI chr10:30,034,447...30,048,774
Ensembl chr10:30,038,709...30,048,085
JBrowse link
G Il17a interleukin 17A multiple interactions ISO [Phenytoin co-treated with Buthionine Sulfoximine] results in increased secretion of IL17A protein CTD PMID:23986454 NCBI chr 9:26,841,299...26,844,786
Ensembl chr 9:26,841,299...26,844,786
JBrowse link
G Il1a interleukin 1 alpha multiple interactions ISO [zomepirac co-treated with Buthionine Sulfoximine co-treated with tri-o-cresyl phosphate] results in increased expression of IL1A mRNA; LY6G protein affects the reaction [[zomepirac co-treated with Buthionine Sulfoximine co-treated with tri-o-cresyl phosphate] results in increased expression of IL1A mRNA] CTD PMID:29154782 NCBI chr 3:121,824,712...121,836,122
Ensembl chr 3:121,825,412...121,836,086
JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases secretion
EXP
ISO
[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased expression of IL1B mRNA; Acetylcysteine inhibits the reaction [[Buthionine Sulfoximine co-treated with Lipopolysaccharides] results in increased secretion of IL1B protein]; Acetylcysteine inhibits the reaction [Buthionine Sulfoximine results in increased secretion of IL1B protein]; Buthionine Sulfoximine promotes the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]
[Phenytoin co-treated with Buthionine Sulfoximine] results in increased expression of IL1B mRNA; [Phenytoin co-treated with Buthionine Sulfoximine] results in increased secretion of IL1B protein; Buthionine Sulfoximine inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]; Buthionine Sulfoximine promotes the reaction [hydroxyethyl methacrylate inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]]; Buthionine Sulfoximine promotes the reaction [Tobacco Smoke Pollution results in increased secretion of and results in increased expression of IL1B protein]
CTD PMID:11970852 PMID:12433058 PMID:23986454 PMID:26149495 PMID:26177832 PMID:28188892 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il23a interleukin 23 subunit alpha multiple interactions ISO [Phenytoin co-treated with Buthionine Sulfoximine] results in increased expression of IL23A mRNA CTD PMID:23986454 NCBI chr 7:2,710,609...2,712,723
Ensembl chr 7:2,710,609...2,712,723
JBrowse link
G Il4 interleukin 4 multiple interactions ISO [Methimazole co-treated with Buthionine Sulfoximine] results in increased expression of IL4 protein; Buthionine Sulfoximine promotes the reaction [Methimazole results in increased expression of IL4 protein] CTD PMID:22407903 PMID:27421576 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
JBrowse link
G Il6 interleukin 6 increases secretion
multiple interactions
EXP
ISO
Buthionine Sulfoximine results in increased secretion of IL6 protein
[Methimazole co-treated with Buthionine Sulfoximine] results in increased expression of IL6 mRNA; [Phenytoin co-treated with Buthionine Sulfoximine] results in increased expression of IL6 mRNA; [Pioglitazone co-treated with Buthionine Sulfoximine] results in increased expression of IL6 mRNA; Buthionine Sulfoximine inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]; Buthionine Sulfoximine inhibits the reaction [manganese chloride promotes the reaction [Lipopolysaccharides results in increased expression of IL6 protein]]; Buthionine Sulfoximine inhibits the reaction [methyldithiocarbamate inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]]
[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased expression of IL6 mRNA; Acetylcysteine inhibits the reaction [[Buthionine Sulfoximine co-treated with Lipopolysaccharides] results in increased secretion of IL6 protein]; Acetylcysteine inhibits the reaction [Buthionine Sulfoximine results in increased secretion of IL6 protein]; Buthionine Sulfoximine promotes the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]; gadolinium chloride inhibits the reaction [[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased expression of IL6 mRNA]
CTD PMID:11970852 PMID:12433058 PMID:15601679 PMID:19339665 PMID:23986454 PMID:26177832 PMID:27421576 PMID:28263783 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Jak1 Janus kinase 1 increases expression ISO Buthionine Sulfoximine results in increased expression of JAK1 mRNA CTD PMID:15878706 NCBI chr 5:119,982,503...120,091,452
Ensembl chr 5:119,982,943...120,083,904
JBrowse link
G Jak2 Janus kinase 2 decreases expression ISO Buthionine Sulfoximine results in decreased expression of JAK2 mRNA CTD PMID:15878706 NCBI chr 1:247,398,667...247,457,521
Ensembl chr 1:247,398,598...247,458,509
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression
decreases activity
ISO
EXP
Buthionine Sulfoximine inhibits the reaction [Sodium Selenite results in increased expression of JUN mRNA]; Buthionine Sulfoximine promotes the reaction [Asbestos, Crocidolite results in increased expression of JUN mRNA]; Buthionine Sulfoximine promotes the reaction [Trioxsalen analog results in decreased activity of JUN protein]; Glucosamine analog inhibits the reaction [Buthionine Sulfoximine results in increased expression of JUN mRNA]
Buthionine Sulfoximine inhibits the reaction [Cadmium Chloride results in increased expression of JUN mRNA]
Buthionine Sulfoximine results in decreased activity of JUN protein
CTD PMID:7626009 PMID:7743507 PMID:11341981 PMID:11841787 PMID:11849044 PMID:15520183 PMID:16259964 PMID:18449455 PMID:21825963 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Junb JunB proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO Buthionine Sulfoximine promotes the reaction [Asbestos, Crocidolite results in increased expression of JUNB mRNA] CTD PMID:15520183 NCBI chr19:26,092,972...26,094,756
Ensembl chr19:26,092,974...26,094,756
JBrowse link
G Kcna4 potassium voltage-gated channel subfamily A member 4 multiple interactions EXP [Carmustine co-treated with Buthionine Sulfoximine] results in decreased expression of KCNA4 protein CTD PMID:16288907 NCBI chr 3:98,293,295...98,300,763
Ensembl chr 3:98,297,554...98,300,680
JBrowse link
G Kcnd2 potassium voltage-gated channel subfamily D member 2 multiple interactions EXP [Carmustine co-treated with Buthionine Sulfoximine] results in decreased expression of KCND2 mRNA; [Carmustine co-treated with Buthionine Sulfoximine] results in decreased expression of KCND2 protein CTD PMID:16288907 NCBI chr 4:48,309,283...48,816,804 JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 multiple interactions ISO Buthionine Sulfoximine inhibits the reaction [[KEAP1 gene mutant form results in increased activity of NFE2L2] which results in decreased susceptibility to Acrolein]; Buthionine Sulfoximine inhibits the reaction [[KEAP1 gene mutant form results in increased activity of NFE2L2] which results in decreased susceptibility to Chlorambucil]; Buthionine Sulfoximine inhibits the reaction [[KEAP1 gene mutant form results in increased activity of NFE2L2] which results in decreased susceptibility to cumene hydroperoxide]; Buthionine Sulfoximine inhibits the reaction [[KEAP1 gene mutant form results in increased activity of NFE2L2] which results in increased abundance of Glutathione] CTD PMID:19608619 NCBI chr 8:22,250,518...22,259,868
Ensembl chr 8:22,250,518...22,259,779
JBrowse link
G Klf4 Kruppel like factor 4 multiple interactions ISO Buthionine Sulfoximine inhibits the reaction [KLF4 results in decreased susceptibility to Cisplatin] CTD PMID:21833590 NCBI chr 5:72,283,311...72,287,669
Ensembl chr 5:72,283,313...72,287,669
JBrowse link
G Klf6 Kruppel-like factor 6 multiple interactions ISO Buthionine Sulfoximine promotes the reaction [[CYP2E1 protein co-treated with Vitamin K 3] results in increased expression of KLF6 protein] CTD PMID:22486562 NCBI chr17:67,887,939...67,945,052
Ensembl chr17:67,887,939...67,945,037
JBrowse link
G Kpnb1 karyopherin subunit beta 1 increases expression EXP Buthionine Sulfoximine results in increased expression of KPNB1 protein CTD PMID:23736079 NCBI chr10:85,096,517...85,124,641
Ensembl chr10:85,093,841...85,124,644
JBrowse link
G Lcn2 lipocalin 2 increases expression
multiple interactions
EXP
ISO
Buthionine Sulfoximine results in increased expression of LCN2 mRNA
[Buthionine Sulfoximine co-treated with Atorvastatin co-treated with Ciprofloxacin] results in increased expression of LCN2 mRNA; [Buthionine Sulfoximine co-treated with Lovastatin co-treated with Gemfibrozil] results in increased expression of LCN2 mRNA; [zomepirac co-treated with Buthionine Sulfoximine co-treated with tri-o-cresyl phosphate] results in increased expression of LCN2 mRNA; LY6G protein affects the reaction [[zomepirac co-treated with Buthionine Sulfoximine co-treated with tri-o-cresyl phosphate] results in increased expression of LCN2 mRNA]
Diclofenac promotes the reaction [Buthionine Sulfoximine results in increased expression of LCN2 mRNA]
CTD PMID:23939143 PMID:29154782 PMID:29679711 PMID:30853469 NCBI chr 3:11,414,189...11,417,534
Ensembl chr 3:11,414,186...11,417,546
JBrowse link
G Lef1 lymphoid enhancer binding factor 1 multiple interactions ISO [Methimazole co-treated with Buthionine Sulfoximine] results in decreased expression of LEF1 protein CTD PMID:27421576 NCBI chr 2:236,232,115...236,345,061
Ensembl chr 2:236,233,239...236,345,056
JBrowse link
G Lrpprc leucine-rich pentatricopeptide repeat containing increases expression EXP Buthionine Sulfoximine results in increased expression of LRPPRC protein CTD PMID:23736079 NCBI chr 6:7,984,043...8,066,874
Ensembl chr 6:7,984,019...8,066,868
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions EXP
ISO
[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased phosphorylation of MAPK1 protein; Buthionine Sulfoximine promotes the reaction [Cadmium Chloride results in increased phosphorylation of MAPK1 protein]; Buthionine Sulfoximine promotes the reaction [chromium hexavalent ion results in increased activity of MAPK1 protein]; gadolinium chloride inhibits the reaction [[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased phosphorylation of MAPK1 protein]
[Buthionine Sulfoximine results in decreased abundance of Glutathione] which results in increased phosphorylation of MAPK1 protein; [ferric ammonium citrate co-treated with Buthionine Sulfoximine] results in decreased phosphorylation of MAPK1 protein; Buthionine Sulfoximine promotes the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased phosphorylation of MAPK1 protein]
CTD PMID:8616849 PMID:17191120 PMID:21971136 PMID:24401988 PMID:26177832 PMID:31860779 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk11 mitogen-activated protein kinase 11 decreases expression
multiple interactions
ISO Buthionine Sulfoximine results in decreased expression of MAPK11 mRNA
Sodium Selenite inhibits the reaction [Buthionine Sulfoximine results in decreased expression of MAPK11 mRNA]
CTD PMID:17989939 NCBI chr 7:130,121,678...130,129,199
Ensembl chr 7:130,121,687...130,128,604
JBrowse link
G Mapk14 mitogen activated protein kinase 14 increases phosphorylation ISO Buthionine Sulfoximine results in increased phosphorylation of MAPK14 protein CTD PMID:17191120 NCBI chr20:5,933,290...5,995,137
Ensembl chr20:5,933,303...5,995,137
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions EXP
ISO
[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased phosphorylation of MAPK3 protein; Buthionine Sulfoximine promotes the reaction [Cadmium Chloride results in increased phosphorylation of MAPK3 protein]; Buthionine Sulfoximine promotes the reaction [chromium hexavalent ion results in increased activity of MAPK3 protein]; gadolinium chloride inhibits the reaction [[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased phosphorylation of MAPK3 protein]
[Buthionine Sulfoximine results in decreased abundance of Glutathione] which results in increased phosphorylation of MAPK3 protein; [ferric ammonium citrate co-treated with Buthionine Sulfoximine] results in decreased phosphorylation of MAPK3 protein; Buthionine Sulfoximine promotes the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased phosphorylation of MAPK3 protein]
CTD PMID:8616849 PMID:17191120 PMID:21971136 PMID:24401988 PMID:26177832 PMID:31860779 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO [antimony trioxide co-treated with Buthionine Sulfoximine] results in decreased expression of MAPK8 protein; Buthionine Sulfoximine promotes the reaction [antimony trioxide results in increased activity of MAPK8 protein]; Buthionine Sulfoximine promotes the reaction [arsenic trioxide results in increased activity of MAPK8 protein] CTD PMID:14701702 PMID:16112521 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 decreases phosphorylation ISO Buthionine Sulfoximine results in decreased phosphorylation of MAPK9 protein CTD PMID:17191120 NCBI chr10:35,333,859...35,374,364
Ensembl chr10:35,333,859...35,374,355
JBrowse link
G Mars1 methionyl-tRNA synthetase 1 increases expression EXP Buthionine Sulfoximine results in increased expression of MARS1 protein CTD PMID:23736079 NCBI chr 7:70,585,011...70,602,425
Ensembl chr 7:70,585,013...70,602,310
JBrowse link
G Mb myoglobin multiple interactions ISO [Buthionine Sulfoximine co-treated with Atorvastatin co-treated with Ciprofloxacin] results in increased secretion of MB protein CTD PMID:29679711 NCBI chr 7:118,101,633...118,108,864
Ensembl chr 7:118,101,634...118,108,864
JBrowse link
G Mef2a myocyte enhancer factor 2a increases expression ISO Buthionine Sulfoximine results in increased expression of MEF2A mRNA CTD PMID:15878706 NCBI chr 1:128,207,715...128,341,681
Ensembl chr 1:128,209,971...128,341,263
JBrowse link
G Mgmt O-6-methylguanine-DNA methyltransferase multiple interactions
decreases activity
ISO Buthionine Sulfoximine inhibits the reaction [MGMT protein results in increased susceptibility to Mitomycin]
Buthionine Sulfoximine results in decreased activity of MGMT protein
CTD PMID:16039682 PMID:16950796 NCBI chr 1:209,237,255...209,464,189
Ensembl chr 1:209,237,233...209,464,190
JBrowse link
G Mir101-2 microRNA 101-2 multiple interactions ISO [Methimazole co-treated with Buthionine Sulfoximine] results in increased expression of MIR101B mRNA CTD PMID:27421576 NCBI chr 1:247,263,723...247,263,819
Ensembl chr 1:247,263,723...247,263,819
JBrowse link
G Mir106b microRNA 106b multiple interactions ISO [Methimazole co-treated with Buthionine Sulfoximine] results in decreased expression of MIR106B mRNA CTD PMID:27421576 NCBI chr12:19,307,752...19,307,833
Ensembl chr12:19,307,752...19,307,833
JBrowse link
G Mir127 microRNA 127 multiple interactions ISO [Methimazole co-treated with Buthionine Sulfoximine] results in increased expression of MIR127 mRNA CTD PMID:27421576 NCBI chr 6:133,713,430...133,713,526
Ensembl chr 6:133,713,430...133,713,526
JBrowse link
G Mir133b microRNA 133b multiple interactions ISO [Buthionine Sulfoximine co-treated with Atorvastatin co-treated with Ciprofloxacin] results in increased expression of MIR133B mRNA; [Buthionine Sulfoximine co-treated with Lovastatin co-treated with Gemfibrozil] results in increased expression of MIR133B mRNA; [Pioglitazone co-treated with Buthionine Sulfoximine] results in increased expression of MIR133B mRNA CTD PMID:28263783 PMID:29679711 PMID:30853469 NCBI chr 9:26,795,649...26,795,732
Ensembl chr 9:26,795,649...26,795,732
JBrowse link
G Mir136 microRNA 136 multiple interactions ISO [Methimazole co-treated with Buthionine Sulfoximine] results in increased expression of MIR136 mRNA CTD PMID:27421576 NCBI chr 6:133,716,761...133,716,842
Ensembl chr 6:133,716,761...133,716,842
JBrowse link
G Mir137 microRNA 137 multiple interactions ISO [Methimazole co-treated with Buthionine Sulfoximine] results in increased expression of MIR137 mRNA CTD PMID:27421576 NCBI chr 2:221,658,106...221,658,207
Ensembl chr 2:221,658,106...221,658,207
JBrowse link
G Mir138-1 microRNA 138-1 multiple interactions ISO [Methimazole co-treated with Buthionine Sulfoximine] results in decreased expression of MIR138-1 mRNA CTD PMID:27421576 NCBI chr 8:131,731,726...131,731,824
Ensembl chr 8:131,731,726...131,731,824
JBrowse link
G Mir141 microRNA 141 multiple interactions ISO [Methimazole co-treated with Buthionine Sulfoximine] results in decreased expression of MIR141 mRNA CTD PMID:27421576 NCBI chr 4:157,236,346...157,236,439
Ensembl chr 4:157,236,346...157,236,439
JBrowse link
G Mir148b microRNA 148b multiple interactions ISO [Methimazole co-treated with Buthionine Sulfoximine] results in decreased expression of MIR148B mRNA CTD PMID:27421576 NCBI chr 7:144,912,038...144,912,134
Ensembl chr 7:144,912,038...144,912,134
JBrowse link
G Mir151 microRNA 151 multiple interactions ISO [Methimazole co-treated with Buthionine Sulfoximine] results in increased expression of MIR151 mRNA CTD PMID:27421576 NCBI chr 7:114,485,547...114,485,643 JBrowse link
G Mir184 microRNA 184 multiple interactions ISO [Methimazole co-treated with Buthionine Sulfoximine] results in increased expression of MIR184 mRNA CTD PMID:27421576 NCBI chr 8:97,175,657...97,175,733
Ensembl chr 8:97,175,657...97,175,733
JBrowse link
G Mir187 microRNA 187 multiple interactions ISO [Methimazole co-treated with Buthionine Sulfoximine] results in decreased expression of MIR187 mRNA; [Methimazole co-treated with Buthionine Sulfoximine] results in increased expression of MIR187 mRNA CTD PMID:27421576 NCBI chr18:16,390,507...16,390,610
Ensembl chr18:16,390,507...16,390,610
JBrowse link
G Mir188 microRNA 188 multiple interactions ISO [Methimazole co-treated with Buthionine Sulfoximine] results in increased expression of MIR188 mRNA CTD PMID:27421576 NCBI chr  X:16,110,270...16,110,349
Ensembl chr  X:16,110,270...16,110,349
JBrowse link
G Mir190 microRNA 190 multiple interactions ISO [Methimazole co-treated with Buthionine Sulfoximine] results in decreased expression of MIR190A mRNA CTD PMID:27421576 NCBI chr 8:73,030,047...73,030,131
Ensembl chr 8:73,030,047...73,030,131
JBrowse link
G Mir19a microRNA 19a multiple interactions ISO [Methimazole co-treated with Buthionine Sulfoximine] results in increased expression of MIR19A mRNA CTD PMID:27421576 NCBI chr15:100,180,162...100,180,243
Ensembl chr15:100,180,162...100,180,243
JBrowse link
G Mir200a microRNA 200a multiple interactions ISO [Methimazole co-treated with Buthionine Sulfoximine] results in increased expression of MIR200A mRNA CTD PMID:27421576 NCBI chr 5:173,489,366...173,489,454 JBrowse link
G Mir206 microRNA 206 multiple interactions ISO [Buthionine Sulfoximine co-treated with Atorvastatin co-treated with Ciprofloxacin] results in increased expression of MIR206 mRNA; [Buthionine Sulfoximine co-treated with Lovastatin co-treated with Gemfibrozil] results in increased expression of MIR206 mRNA; [Pioglitazone co-treated with Buthionine Sulfoximine] results in increased expression of MIR206 mRNA CTD PMID:28263783 PMID:29679711 PMID:30853469 NCBI chr 9:26,791,764...26,791,847
Ensembl chr 9:26,791,764...26,791,847
JBrowse link
G Mir20b microRNA 20b multiple interactions ISO [Methimazole co-treated with Buthionine Sulfoximine] results in increased expression of MIR20B mRNA CTD PMID:27421576 NCBI chr  X:140,117,518...140,117,589
Ensembl chr  X:140,117,518...140,117,589
JBrowse link
G Mir210 microRNA 210 multiple interactions ISO [Methimazole co-treated with Buthionine Sulfoximine] results in increased expression of MIR210 mRNA CTD PMID:27421576 NCBI chr 1:214,208,355...214,208,464 JBrowse link
G Mir211 microRNA 211 multiple interactions ISO [Methimazole co-treated with Buthionine Sulfoximine] results in increased expression of MIR211 mRNA CTD PMID:27421576 NCBI chr 1:125,042,119...125,042,224
Ensembl chr 1:125,042,119...125,042,224
JBrowse link
G Mir224 microRNA 224 multiple interactions ISO [Methimazole co-treated with Buthionine Sulfoximine] results in decreased expression of MIR224 mRNA CTD PMID:27421576 NCBI chr  X:152,223,754...152,223,835
Ensembl chr  X:152,223,754...152,223,835
JBrowse link
G Mir290 microRNA 290 multiple interactions ISO [Methimazole co-treated with Buthionine Sulfoximine] results in increased expression of MIR292 mRNA CTD PMID:27421576 NCBI chr 1:64,538,705...64,538,785
Ensembl chr 1:64,538,705...64,538,785
JBrowse link
G Mir29b1 microRNA 29b-1 multiple interactions ISO [Methimazole co-treated with Buthionine Sulfoximine] results in increased expression of MIR29B-1 mRNA CTD PMID:27421576 NCBI chr 4:58,344,310...58,344,390
Ensembl chr 4:58,344,310...58,344,390
JBrowse link
G Mir322 microRNA 322 multiple interactions ISO [Methimazole co-treated with Buthionine Sulfoximine] results in decreased expression of MIR322 mRNA; [Methimazole co-treated with Buthionine Sulfoximine] results in increased expression of MIR322 mRNA CTD PMID:27421576 NCBI chr  X:158,148,161...158,148,255
Ensembl chr  X:158,148,161...158,148,255
JBrowse link
G Mir324 microRNA 324 multiple interactions ISO [Methimazole co-treated with Buthionine Sulfoximine] results in decreased expression of MIR324 mRNA CTD PMID:27421576 NCBI chr10:56,621,126...56,621,208
Ensembl chr10:56,621,124...56,621,212
JBrowse link
G Mir328 microRNA 328 multiple interactions ISO [Methimazole co-treated with Buthionine Sulfoximine] results in increased expression of MIR328 mRNA CTD PMID:27421576 NCBI chr19:37,263,199...37,263,282
Ensembl chr19:37,263,199...37,263,282
JBrowse link
G Mir337 microRNA 337 multiple interactions ISO [Methimazole co-treated with Buthionine Sulfoximine] results in increased expression of MIR337 mRNA CTD PMID:27421576 NCBI chr 6:133,705,920...133,706,016
Ensembl chr 6:133,705,920...133,706,016
JBrowse link
G Mir339 microRNA 339 multiple interactions ISO [Methimazole co-treated with Buthionine Sulfoximine] results in increased expression of MIR339 mRNA CTD PMID:27421576 NCBI chr12:17,369,002...17,369,097
Ensembl chr12:17,369,002...17,369,097
JBrowse link
G Mir34b microRNA 34b multiple interactions ISO [Methimazole co-treated with Buthionine Sulfoximine] results in increased expression of MIR34B mRNA CTD PMID:27421576 NCBI chr 8:55,492,542...55,492,625
Ensembl chr 8:55,492,542...55,492,625
JBrowse link
G Mir361 microRNA 361 multiple interactions ISO [Methimazole co-treated with Buthionine Sulfoximine] results in increased expression of MIR361 mRNA CTD PMID:27421576 NCBI chr  X:84,708,911...84,708,980
Ensembl chr  X:84,708,911...84,708,980
JBrowse link
G Mir375 microRNA 375 multiple interactions ISO [Methimazole co-treated with Buthionine Sulfoximine] results in decreased expression of MIR375 mRNA CTD PMID:27421576 NCBI chr 9:82,161,716...82,161,790
Ensembl chr 9:82,161,716...82,161,790
JBrowse link
G Mir410 microRNA 410 multiple interactions ISO [Methimazole co-treated with Buthionine Sulfoximine] results in decreased expression of MIR410 mRNA CTD PMID:27421576 NCBI chr 6:133,893,997...133,894,072
Ensembl chr 6:133,893,993...133,894,073
JBrowse link
G Mir449a microRNA 449a multiple interactions ISO [Methimazole co-treated with Buthionine Sulfoximine] results in decreased expression of MIR449A mRNA; [Methimazole co-treated with Buthionine Sulfoximine] results in increased expression of MIR449A mRNA CTD PMID:27421576 NCBI chr 2:44,897,601...44,897,691
Ensembl chr 2:44,897,601...44,897,691
JBrowse link
G Mir450a1 microRNA 450a-1 multiple interactions ISO [Methimazole co-treated with Buthionine Sulfoximine] results in increased expression of MIR450A1 mRNA CTD PMID:27421576 NCBI chr  X:158,153,377...158,153,467
Ensembl chr  X:158,153,377...158,153,467
JBrowse link
G Mir455 microRNA 455 multiple interactions ISO [Methimazole co-treated with Buthionine Sulfoximine] results in increased expression of MIR455 mRNA CTD PMID:27421576 NCBI chr 5:79,097,208...79,097,285
Ensembl chr 5:79,097,208...79,097,285
JBrowse link
G Mir671 microRNA 671 multiple interactions ISO [Methimazole co-treated with Buthionine Sulfoximine] results in decreased expression of MIR671 mRNA CTD PMID:27421576 NCBI chr 4:7,108,747...7,108,827
Ensembl chr 4:7,108,738...7,108,835
JBrowse link
G Mir99a microRNA 99a multiple interactions ISO [Methimazole co-treated with Buthionine Sulfoximine] results in decreased expression of MIR99A mRNA CTD PMID:27421576 NCBI chr11:16,052,153...16,052,233
Ensembl chr11:16,052,153...16,052,233
JBrowse link
G Mmp1 matrix metallopeptidase 1 multiple interactions ISO [Buthionine Sulfoximine co-treated with SOD2 protein] results in increased expression of MMP1 mRNA; Deferoxamine inhibits the reaction [[Buthionine Sulfoximine co-treated with SOD2 protein] results in increased expression of MMP1 mRNA] CTD PMID:10464329 NCBI chr 8:5,703,206...5,723,593
Ensembl chr 8:5,703,206...5,723,591
JBrowse link
G Mpo myeloperoxidase multiple interactions EXP [Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased expression of MPO protein CTD PMID:26177832 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
JBrowse link
G Mrps7 mitochondrial ribosomal protein S7 increases expression ISO Buthionine Sulfoximine results in increased expression of MRPS7 mRNA CTD PMID:15878706 NCBI chr10:104,155,805...104,158,840
Ensembl chr10:104,155,805...104,158,839
JBrowse link
G Mt1 metallothionein 1 multiple interactions
increases expression
increases activity
ISO
EXP
Buthionine Sulfoximine promotes the reaction [Copper results in increased activity of MT1 promoter]; Buthionine Sulfoximine promotes the reaction [Paraquat results in increased expression of MT1 mRNA]; Dactinomycin inhibits the reaction [Buthionine Sulfoximine promotes the reaction [Paraquat results in increased expression of MT1 mRNA]]
Buthionine Sulfoximine promotes the reaction [Cadmium Chloride results in increased expression of MT1A mRNA]
Buthionine Sulfoximine results in increased expression of MT1A mRNA
Buthionine Sulfoximine results in increased activity of MT1 promoter
CTD PMID:7626009 PMID:8966720 PMID:9152014 PMID:14576086 NCBI chr19:11,301,991...11,303,007
Ensembl chr17:78,793,336...78,793,724
JBrowse link
G Mt2A metallothionein 2A multiple interactions ISO [Buthionine Sulfoximine co-treated with Gefitinib] results in increased expression of MT2 mRNA CTD PMID:32741899 NCBI chr19:11,307,966...11,308,740
Ensembl chr19:11,307,967...11,308,740
JBrowse link
G Mtf1 metal-regulatory transcription factor 1 multiple interactions
decreases response to substance
ISO MTF1 results in decreased susceptibility to [Buthionine Sulfoximine co-treated with cadmium sulfate]
MTF1 results in decreased susceptibility to Buthionine Sulfoximine
CTD PMID:16221973 NCBI chr 5:142,797,340...142,843,896
Ensembl chr 5:142,797,366...142,842,122
Ensembl chr 5:142,797,366...142,842,122
JBrowse link
G Mtr 5-methyltetrahydrofolate-homocysteine methyltransferase multiple interactions ISO Buthionine Sulfoximine inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]; Buthionine Sulfoximine inhibits the reaction [mecobalamin results in increased activity of MTR protein alternative form]; Glutathione inhibits the reaction [Buthionine Sulfoximine inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]]; mecobalamin inhibits the reaction [Buthionine Sulfoximine inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]] CTD PMID:26989453 NCBI chr17:66,210,444...66,295,014
Ensembl chr17:66,210,461...66,295,014
JBrowse link
G Nars1 asparaginyl-tRNA synthetase 1 increases expression EXP Buthionine Sulfoximine results in increased expression of NARS1 protein CTD PMID:23736079 NCBI chr18:59,986,350...60,002,644
Ensembl chr18:59,986,360...60,002,569
JBrowse link
G Ndn necdin, MAGE family member increases expression ISO Buthionine Sulfoximine results in increased expression of NDN mRNA CTD PMID:15878706 NCBI chr 1:122,981,755...122,983,354
Ensembl chr 1:122,981,755...122,983,351
JBrowse link
G Ndufa13 NADH:ubiquinone oxidoreductase subunit A13 increases expression ISO Buthionine Sulfoximine results in increased expression of NDUFA13 mRNA CTD PMID:15878706 NCBI chr16:21,275,311...21,282,246
Ensembl chr16:21,275,311...21,282,246
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions
affects expression
increases expression
ISO
EXP
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[Buthionine Sulfoximine results in decreased abundance of Glutathione] which affects the localization of NFE2L2 protein]; [Buthionine Sulfoximine results in decreased abundance of Glutathione] which affects the localization of NFE2L2 protein; Buthionine Sulfoximine inhibits the reaction [[KEAP1 gene mutant form results in increased activity of NFE2L2] which results in decreased susceptibility to Acrolein]; Buthionine Sulfoximine inhibits the reaction [[KEAP1 gene mutant form results in increased activity of NFE2L2] which results in decreased susceptibility to Chlorambucil]; Buthionine Sulfoximine inhibits the reaction [[KEAP1 gene mutant form results in increased activity of NFE2L2] which results in decreased susceptibility to cumene hydroperoxide]; Buthionine Sulfoximine inhibits the reaction [[KEAP1 gene mutant form results in increased activity of NFE2L2] which results in increased abundance of Glutathione]; Buthionine Sulfoximine promotes the reaction [1,2-dihydroxynaphthalene analog results in increased activity of NFE2L2 protein]; Buthionine Sulfoximine promotes the reaction [pterostilbene results in increased phosphorylation of NFE2L2 protein]
Buthionine Sulfoximine inhibits the reaction [decamethrin results in increased expression of and affects the localization of NFE2L2 protein]; Buthionine Sulfoximine inhibits the reaction [decamethrin results in increased expression of NFE2L2 mRNA]; Buthionine Sulfoximine promotes the reaction [arsenic trioxide results in increased expression of and affects the localization of NFE2L2 protein]
Buthionine Sulfoximine affects the expression of NFE2L2 protein
Buthionine Sulfoximine results in increased expression of NFE2L2 mRNA
Buthionine Sulfoximine affects the localization of and results in increased activity of NFE2L2 protein; Buthionine Sulfoximine affects the reaction [[NFE2L2 affects the susceptibility to sulforaphane] which affects the susceptibility to Acrolein]; Buthionine Sulfoximine affects the reaction [[NFE2L2 affects the susceptibility to sulforaphane] which affects the susceptibility to Chlorambucil]; Buthionine Sulfoximine inhibits the reaction [Hypochlorous Acid results in increased expression of NFE2L2 mRNA]; Buthionine Sulfoximine inhibits the reaction [NFE2L2 protein promotes the reaction [sulforaphane results in decreased susceptibility to Acrolein]]; Buthionine Sulfoximine inhibits the reaction [NFE2L2 protein promotes the reaction [sulforaphane results in decreased susceptibility to Chlorambucil]]; Buthionine Sulfoximine inhibits the reaction [NFE2L2 protein promotes the reaction [sulforaphane results in decreased susceptibility to cumene hydroperoxide]]
CTD PMID:17980396 PMID:18785192 PMID:19303893 PMID:19608619 PMID:20932822 PMID:20934533 PMID:21971136 PMID:23585199 PMID:24634002 PMID:25341683 PMID:25807370 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions EXP Buthionine Sulfoximine inhibits the reaction [Lipopolysaccharides affects the localization of NFKB1 protein]; Buthionine Sulfoximine inhibits the reaction [Lipopolysaccharides results in increased activity of [NFKB1 protein binds to RELA protein]] CTD PMID:11970852 PMID:12433058 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions
increases expression
EXP
ISO
Buthionine Sulfoximine inhibits the reaction [Lipopolysaccharides results in increased degradation of NFKBIA protein]; Buthionine Sulfoximine inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein]
NGF protein affects the reaction [Buthionine Sulfoximine results in increased expression of NFKBIA mRNA]
CTD PMID:11970852 PMID:12433058 PMID:23472850 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Ngf nerve growth factor multiple interactions
affects response to substance
increases expression
ISO Acetylcysteine inhibits the reaction [Buthionine Sulfoximine results in increased expression of NGF mRNA]; NGF protein affects the reaction [Buthionine Sulfoximine results in increased expression of NFKBIA mRNA]; NGF protein affects the reaction [Buthionine Sulfoximine results in increased expression of TXN1 mRNA]; NGF protein affects the reaction [Buthionine Sulfoximine results in increased phosphorylation of and results in increased activity of NTRK1 protein]
NGF protein affects the susceptibility to Buthionine Sulfoximine
CTD PMID:23472850 NCBI chr 2:204,886,158...204,939,523
Ensembl chr 2:204,886,202...204,940,453
JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions ISO
EXP
[Phenytoin co-treated with Buthionine Sulfoximine] results in increased expression of NLRP3 mRNA
[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased expression of NLRP3 mRNA
CTD PMID:23986454 PMID:26177832 NCBI chr10:45,884,324...45,918,290
Ensembl chr10:45,893,018...45,918,254
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
increases expression
EXP
ISO
[Carmustine co-treated with Buthionine Sulfoximine] inhibits the reaction [TNF protein results in increased expression of NOS2 protein]; Buthionine Sulfoximine inhibits the reaction [TNF protein results in increased expression of NOS2 mRNA]; Buthionine Sulfoximine promotes the reaction [Carmustine inhibits the reaction [TNF protein results in increased expression of NOS2 mRNA]]; Buthionine Sulfoximine promotes the reaction [Potassium Cyanide results in increased expression of NOS2 protein]; Nitrites inhibits the reaction [[TNF protein results in increased activity of NOS2 protein] which results in increased chemical synthesis of Buthionine Sulfoximine]
Buthionine Sulfoximine results in increased expression of NOS2 mRNA
[ferric ammonium citrate co-treated with Buthionine Sulfoximine] results in increased expression of NOS2 mRNA; Acetylcysteine inhibits the reaction [[ferric ammonium citrate co-treated with Buthionine Sulfoximine] results in increased expression of NOS2 mRNA]
Buthionine Sulfoximine promotes the reaction [Trioxsalen analog results in decreased expression of NOS2 mRNA]
CTD PMID:7532384 PMID:9826428 PMID:16259964 PMID:16933320 PMID:23939143 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Npc1 NPC intracellular cholesterol transporter 1 decreases expression ISO Buthionine Sulfoximine results in decreased expression of NPC1 mRNA CTD PMID:15878706 NCBI chr18:3,616,878...3,662,656
Ensembl chr18:3,616,878...3,662,683
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases activity
increases expression
multiple interactions
EXP
ISO
Buthionine Sulfoximine results in increased activity of NQO1 protein
Buthionine Sulfoximine results in increased expression of NQO1 mRNA
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[Buthionine Sulfoximine results in decreased abundance of Glutathione] which results in increased expression of NQO1 mRNA]; [Buthionine Sulfoximine results in decreased abundance of Glutathione] which results in increased expression of NQO1 mRNA; Buthionine Sulfoximine promotes the reaction [pterostilbene results in increased expression of NQO1 mRNA]; TNF protein inhibits the reaction [[Buthionine Sulfoximine results in decreased abundance of Glutathione] which results in increased expression of NQO1 mRNA]
[Buthionine Sulfoximine co-treated with chromium trioxide] results in increased activity of NQO1 protein; [Buthionine Sulfoximine co-treated with chromium trioxide] results in increased expression of NQO1 mRNA; [Tetrachlorodibenzodioxin co-treated with chromium trioxide co-treated with Buthionine Sulfoximine] results in increased expression of NQO1 mRNA; Buthionine Sulfoximine inhibits the reaction [chromium trioxide inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of NQO1 protein]]; Buthionine Sulfoximine inhibits the reaction [sodium arsenite promotes the reaction [Tetrachlorodibenzodioxin results in increased activity of NQO1 protein]]; Buthionine Sulfoximine inhibits the reaction [sodium arsenite results in increased activity of NQO1 protein]; Buthionine Sulfoximine promotes the reaction [[Benzene co-treated with Toluene] results in increased activity of NQO1 protein]; Buthionine Sulfoximine promotes the reaction [Arsenic Trioxide promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of NQO1 mRNA]]; Buthionine Sulfoximine promotes the reaction [Benzene results in increased activity of NQO1 protein]; Buthionine Sulfoximine promotes the reaction [Cadmium Chloride promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of NQO1 mRNA]]; Buthionine Sulfoximine promotes the reaction [Cadmium Chloride results in increased activity of NQO1 protein]; Buthionine Sulfoximine promotes the reaction [Cadmium Chloride results in increased expression of NQO1 mRNA]; Buthionine Sulfoximine promotes the reaction [Copper results in increased expression of NQO1 mRNA]; Buthionine Sulfoximine promotes the reaction [Copper results in increased expression of NQO1 protein]; Buthionine Sulfoximine promotes the reaction [Lead results in increased expression of NQO1 mRNA]; Buthionine Sulfoximine promotes the reaction [Lead results in increased expression of NQO1 protein]; Buthionine Sulfoximine promotes the reaction [Mercury results in increased expression of NQO1 mRNA]; Buthionine Sulfoximine promotes the reaction [Mercury results in increased expression of NQO1 protein]; Buthionine Sulfoximine promotes the reaction [sodium arsenite results in increased expression of NQO1 mRNA]
[Buthionine Sulfoximine co-treated with Endosulfan] results in increased expression of NQO1 mRNA; Buthionine Sulfoximine promotes the reaction [Methylcholanthrene results in increased activity of NQO1 protein]; Methylcholanthrene promotes the reaction [Buthionine Sulfoximine results in increased activity of NQO1 protein]
CTD PMID:16274885 PMID:16906435 PMID:18752316 PMID:20079720 PMID:21971136 PMID:22146149 PMID:25341683 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Nr2f2 nuclear receptor subfamily 2, group F, member 2 increases expression ISO Buthionine Sulfoximine results in increased expression of NR2F2 mRNA CTD PMID:15878706 NCBI chr 1:131,447,671...131,465,749
Ensembl chr 1:131,448,447...131,460,473
JBrowse link
G Ntrk1 neurotrophic receptor tyrosine kinase 1 multiple interactions ISO Acetylcysteine inhibits the reaction [Buthionine Sulfoximine results in increased phosphorylation of and results in increased activity of NTRK1 protein]; Buthionine Sulfoximine results in increased phosphorylation of and results in increased activity of NTRK1 protein; NGF protein affects the reaction [Buthionine Sulfoximine results in increased phosphorylation of and results in increased activity of NTRK1 protein] CTD PMID:23472850 NCBI chr 2:187,143,568...187,160,373
Ensembl chr 2:187,143,568...187,160,373
JBrowse link
G Nupr1 nuclear protein 1, transcriptional regulator decreases expression ISO Buthionine Sulfoximine results in decreased expression of NUPR1 mRNA CTD PMID:15878706 NCBI chr 1:194,767,484...194,769,519
Ensembl chr 1:194,767,474...194,769,524
JBrowse link
G Odc1 ornithine decarboxylase 1 increases expression EXP Buthionine Sulfoximine results in increased expression of ODC1 protein CTD PMID:9763232 NCBI chr 6:42,852,529...42,859,142
Ensembl chr 6:42,852,683...42,859,927
JBrowse link
G Ogg1 8-oxoguanine DNA glycosylase multiple interactions
affects response to substance
ISO Buthionine Sulfoximine affects the reaction [OGG1 protein affects the expression of SOD2 mRNA]
OGG1 protein affects the susceptibility to Buthionine Sulfoximine
CTD PMID:32585298 NCBI chr 4:145,282,828...145,289,367
Ensembl chr 4:145,282,797...145,289,326
JBrowse link
G Orm1 orosomucoid 1 increases expression EXP Buthionine Sulfoximine results in increased expression of ORM1 mRNA; Buthionine Sulfoximine results in increased expression of ORM1 protein CTD PMID:11841787 NCBI chr 5:79,179,668...79,182,820
Ensembl chr 5:79,179,417...79,182,820
JBrowse link
G P4ha1 prolyl 4-hydroxylase subunit alpha 1 decreases expression ISO Buthionine Sulfoximine results in decreased expression of P4HA1 mRNA CTD PMID:15878706 NCBI chr20:28,920,616...28,972,576
Ensembl chr20:28,920,616...28,971,966
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO Buthionine Sulfoximine promotes the reaction [O(2)-(2,4-dinitrophenyl) 1-((4-ethoxycarbonyl)piperazin-1-yl)diazen-1-ium-1,2-diolate affects the cleavage of PARP1 protein]; Buthionine Sulfoximine promotes the reaction [wedelolactone results in increased cleavage of PARP1 protein] CTD PMID:20962031 PMID:22733624 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1 increases expression
multiple interactions
EXP Buthionine Sulfoximine results in increased expression of PCK1 mRNA
SB 203580 inhibits the reaction [Buthionine Sulfoximine results in increased expression of PCK1 mRNA]
CTD PMID:16960379 NCBI chr 3:171,213,936...171,219,885
Ensembl chr 3:171,213,936...171,219,871
JBrowse link
G Pcna proliferating cell nuclear antigen increases expression EXP
ISO
Buthionine Sulfoximine results in increased expression of PCNA protein
Buthionine Sulfoximine results in increased expression of PCNA mRNA
CTD PMID:9763232 PMID:15707499 NCBI chr 3:124,880,698...124,884,570
Ensembl chr 3:124,880,698...124,884,570
JBrowse link
G Pdgfrb platelet derived growth factor receptor beta multiple interactions ISO Buthionine Sulfoximine inhibits the reaction [Acetylcysteine inhibits the reaction [Copper Sulfate results in increased expression of PDGFRB mRNA]]; Buthionine Sulfoximine inhibits the reaction [Acetylcysteine inhibits the reaction [Copper Sulfate results in increased expression of PDGFRB protein]] CTD PMID:23392711 NCBI chr18:56,364,586...56,406,381
Ensembl chr18:56,364,620...56,406,381
JBrowse link
G Pdia3 protein disulfide isomerase family A, member 3 increases expression EXP Buthionine Sulfoximine results in increased expression of PDIA3 protein CTD PMID:23736079 NCBI chr 3:113,376,983...113,400,707
Ensembl chr 3:113,376,983...113,400,707
JBrowse link
G Pdk1 pyruvate dehydrogenase kinase 1 multiple interactions ISO Buthionine Sulfoximine promotes the reaction [Curcumin results in increased phosphorylation of PDK1 protein] CTD PMID:17171638 NCBI chr 3:58,530,870...58,561,494
Ensembl chr 3:58,530,870...58,558,027
JBrowse link
G Pfas phosphoribosylformylglycinamidine synthase increases expression EXP Buthionine Sulfoximine results in increased expression of PFAS protein CTD PMID:23736079 NCBI chr10:55,571,881...55,593,384
Ensembl chr10:55,571,118...55,589,978
JBrowse link
G Phtf1 putative homeodomain transcription factor 1 increases expression ISO Buthionine Sulfoximine results in increased expression of PHTF1 mRNA CTD PMID:15878706 NCBI chr 2:206,452,115...206,518,387
Ensembl chr 2:206,454,208...206,493,030
JBrowse link
G Plxna3 plexin A3 decreases expression ISO Buthionine Sulfoximine results in decreased expression of PLXNA3 mRNA CTD PMID:15878706 NCBI chr  X:156,363,400...156,379,433
Ensembl chr  X:156,363,405...156,379,189
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions
increases expression
ISO
EXP
PPARG mRNA promotes the reaction [Tamoxifen inhibits the reaction [Buthionine Sulfoximine results in increased expression of CD36 protein]]; S-ethyl glutathione inhibits the reaction [Buthionine Sulfoximine results in increased expression of PPARG mRNA]
Buthionine Sulfoximine inhibits the reaction [Acetylcysteine results in increased expression of PPARG mRNA]; Buthionine Sulfoximine inhibits the reaction [Acetylcysteine results in increased expression of PPARG protein]; Buthionine Sulfoximine inhibits the reaction [Curcumin results in increased expression of PPARG mRNA]; Buthionine Sulfoximine inhibits the reaction [Curcumin results in increased expression of PPARG protein]
CTD PMID:17602960 PMID:21520053 PMID:27358406 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Ppm1g protein phosphatase, Mg2+/Mn2+ dependent, 1G decreases expression ISO Buthionine Sulfoximine results in decreased expression of PPM1G mRNA CTD PMID:15878706 NCBI chr 6:26,517,840...26,537,292
Ensembl chr 6:26,517,840...26,537,290
JBrowse link
G Ppp3ca protein phosphatase 3 catalytic subunit alpha increases expression ISO Buthionine Sulfoximine results in increased expression of PPP3CA mRNA CTD PMID:15878706 NCBI chr 2:241,909,332...242,186,861
Ensembl chr 2:241,909,832...242,184,854
JBrowse link
G Ppp5c protein phosphatase 5, catalytic subunit decreases expression ISO Buthionine Sulfoximine results in decreased expression of PPP5C mRNA CTD PMID:15878706 NCBI chr 1:78,944,054...78,968,361
Ensembl chr 1:78,944,040...78,968,329
JBrowse link
G Prdx1 peroxiredoxin 1 increases expression
affects expression
ISO Buthionine Sulfoximine results in increased expression of PRDX1 mRNA
Buthionine Sulfoximine affects the expression of PRDX1 mRNA
CTD PMID:9506838 PMID:15707499 NCBI chr 5:135,536,413...135,551,986
Ensembl chr 5:135,536,413...135,551,990
JBrowse link
G Prim2 DNA primase subunit 2 decreases expression ISO Buthionine Sulfoximine results in decreased expression of PRIM2 mRNA CTD PMID:15878706 NCBI chr 9:38,535,435...38,745,058
Ensembl chr 9:38,536,920...38,745,099
JBrowse link
G Prkca protein kinase C, alpha decreases activity EXP Buthionine Sulfoximine results in decreased activity of PRKCA protein CTD PMID:11118818 NCBI chr10:96,186,509...96,585,168
Ensembl chr10:96,191,133...96,584,947
JBrowse link
G Prkcb protein kinase C, beta decreases activity EXP Buthionine Sulfoximine results in decreased activity of PRKCB protein CTD PMID:11118818 NCBI chr 1:192,233,569...192,575,339
Ensembl chr 1:192,233,910...192,574,831
JBrowse link
G Prkcd protein kinase C, delta multiple interactions ISO
EXP
Buthionine Sulfoximine promotes the reaction [Curcumin results in increased phosphorylation of PRKCD protein]
Buthionine Sulfoximine results in increased expression of and results in increased activity of PRKCD protein; Cycloheximide inhibits the reaction [Buthionine Sulfoximine results in increased expression of PRKCD protein]
CTD PMID:11118818 PMID:17171638 NCBI chr16:6,655,131...6,675,746
Ensembl chr16:6,655,120...6,675,746
JBrowse link
G Prkce protein kinase C, epsilon multiple interactions EXP Buthionine Sulfoximine results in increased expression of and results in increased activity of PRKCE protein; Cycloheximide inhibits the reaction [Buthionine Sulfoximine results in increased expression of PRKCE protein] CTD PMID:11118818 NCBI chr 6:9,483,400...9,973,396
Ensembl chr 6:9,790,422...9,973,396
JBrowse link
G Prpf19 pre-mRNA processing factor 19 increases expression EXP Buthionine Sulfoximine results in increased expression of PRPF19 protein CTD PMID:23736079 NCBI chr 1:226,947,065...226,958,147
Ensembl chr 1:226,947,105...226,958,144
JBrowse link
G Pten phosphatase and tensin homolog multiple interactions ISO Buthionine Sulfoximine promotes the reaction [Cadmium Chloride results in increased degradation of and results in decreased expression of PTEN protein]; Buthionine Sulfoximine promotes the reaction [Cadmium results in increased degradation of and results in decreased expression of PTEN protein] CTD PMID:24449419 NCBI chr 1:251,421,814...251,487,634
Ensembl chr 1:251,421,596...251,487,832
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO Buthionine Sulfoximine promotes the reaction [sodium arsenite results in increased expression of PTGS2 mRNA] CTD PMID:23376440 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Ptk2 protein tyrosine kinase 2 increases expression ISO Buthionine Sulfoximine results in increased expression of PTK2 mRNA CTD PMID:15878706 NCBI chr 7:114,436,419...114,611,317
Ensembl chr 7:114,437,361...114,590,119
JBrowse link
G Ptpn1 protein tyrosine phosphatase, non-receptor type 1 increases oxidation EXP Buthionine Sulfoximine results in increased oxidation of PTPN1 protein CTD PMID:20482862 NCBI chr 3:164,665,462...164,711,936
Ensembl chr 3:164,665,532...164,711,848
JBrowse link
G Pttg1 PTTG1 regulator of sister chromatid separation, securin increases expression ISO Buthionine Sulfoximine results in increased expression of PTTG1 mRNA CTD PMID:15878706 NCBI chr10:29,014,332...29,026,088
Ensembl chr10:29,020,049...29,026,002
JBrowse link
G Rbbp6 RB binding protein 6, ubiquitin ligase decreases expression ISO Buthionine Sulfoximine results in decreased expression of RBBP6 mRNA CTD PMID:15878706 NCBI chr 1:192,933,264...192,965,160
Ensembl chr 1:192,933,540...192,965,158
JBrowse link
G Rel REL proto-oncogene, NF-kB subunit multiple interactions EXP Buthionine Sulfoximine inhibits the reaction [Lipopolysaccharides affects the localization of REL protein] CTD PMID:11970852 PMID:12433058 NCBI chr14:108,490,794...108,517,582
Ensembl chr14:108,491,069...108,509,892
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
increases expression
ISO
EXP
[Buthionine Sulfoximine results in decreased abundance of Glutathione] inhibits the reaction [cinnamic aldehyde results in increased glutathionylation of RELA protein]; Buthionine Sulfoximine inhibits the reaction [carnosol inhibits the reaction [TNF protein affects the localization of RELA protein]]; Buthionine Sulfoximine inhibits the reaction [carnosol results in increased glutathionylation of RELA protein]; Buthionine Sulfoximine inhibits the reaction [cinnamic aldehyde inhibits the reaction [TNF protein affects the localization of RELA protein]]
Buthionine Sulfoximine inhibits the reaction [Lipopolysaccharides affects the localization of RELA protein]; Buthionine Sulfoximine inhibits the reaction [Lipopolysaccharides results in increased activity of [NFKB1 protein binds to RELA protein]]
Buthionine Sulfoximine promotes the reaction [Sodium Selenite results in increased expression of RELA mRNA]
Buthionine Sulfoximine results in increased expression of RELA mRNA
CTD PMID:11970852 PMID:12433058 PMID:18449455 PMID:20116392 PMID:20351055 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Relb RELB proto-oncogene, NF-kB subunit multiple interactions EXP Buthionine Sulfoximine inhibits the reaction [Lipopolysaccharides affects the localization of RELB protein] CTD PMID:11970852 PMID:12433058 NCBI chr 1:80,517,081...80,545,019
Ensembl chr 1:80,517,411...80,544,825
JBrowse link
G Rorc RAR-related orphan receptor C increases expression EXP Buthionine Sulfoximine results in increased expression of RORC mRNA CTD PMID:26177832 NCBI chr 2:195,612,471...195,636,797
Ensembl chr 2:195,617,021...195,637,630
JBrowse link
G Rpl10a ribosomal protein L10A increases expression ISO Buthionine Sulfoximine results in increased expression of RPL10A mRNA CTD PMID:15878706 NCBI chr20:7,908,309...7,910,867
Ensembl chr20:7,908,304...7,910,867
JBrowse link
G Rpl12 ribosomal protein L12 increases expression ISO Buthionine Sulfoximine results in increased expression of RPL12 mRNA CTD PMID:15878706 NCBI chr 3:12,009,578...12,011,952
Ensembl chr 3:12,009,578...12,011,666
JBrowse link
G Rpl3 ribosomal protein L3 decreases expression ISO Buthionine Sulfoximine results in decreased expression of RPL3 mRNA CTD PMID:15878706 NCBI chr 7:121,297,365...121,302,739
Ensembl chr 7:121,297,355...121,311,565
JBrowse link
G Rpl6 ribosomal protein L6 increases expression ISO Buthionine Sulfoximine results in increased expression of RPL6 mRNA CTD PMID:15707499 NCBI chr12:40,877,578...40,882,032
Ensembl chr12:40,877,613...40,881,124
JBrowse link
G Rpl8 ribosomal protein L8 increases expression ISO Buthionine Sulfoximine results in increased expression of RPL8 mRNA CTD PMID:15878706 NCBI chr 7:117,967,608...117,969,886
Ensembl chr 7:118,507,224...118,509,256
Ensembl chr 3:118,507,224...118,509,256
Ensembl chr 7:118,507,224...118,509,256
JBrowse link
G Rplp0 ribosomal protein lateral stalk subunit P0 increases expression ISO Buthionine Sulfoximine results in increased expression of RPLP0 mRNA CTD PMID:15878706 NCBI chr12:46,791,528...46,794,797
Ensembl chr12:46,791,528...46,794,797
JBrowse link
G Rplp1 ribosomal protein lateral stalk subunit P1 increases expression ISO Buthionine Sulfoximine results in increased expression of RPLP1 mRNA CTD PMID:15878706 NCBI chr 8:66,862,143...66,863,476
Ensembl chr 8:66,862,143...66,863,476
JBrowse link
G Rps12 ribosomal protein S12 increases expression ISO Buthionine Sulfoximine results in increased expression of RPS12 mRNA CTD PMID:15878706 NCBI chr 1:22,758,214...22,760,370
Ensembl chr 1:22,758,212...22,760,370
JBrowse link
G Rps14 ribosomal protein S14 increases expression ISO Buthionine Sulfoximine results in increased expression of RPS14 mRNA CTD PMID:15878706 NCBI chr18:56,042,532...56,047,316
Ensembl chr18:56,044,369...56,047,316
JBrowse link
G Rps15 ribosomal protein S15 increases expression ISO Buthionine Sulfoximine results in increased expression of RPS15 mRNA CTD PMID:15878706 NCBI chr 7:12,282,134...12,283,573
Ensembl chr 7:12,282,109...12,283,608
JBrowse link
G Rps20 ribosomal protein S20 increases expression ISO Buthionine Sulfoximine results in increased expression of RPS20 mRNA CTD PMID:15878706 NCBI chr 5:16,706,052...16,707,214
Ensembl chr 5:16,706,082...16,706,909
JBrowse link
G Rps26 ribosomal protein S26 increases expression ISO Buthionine Sulfoximine results in increased expression of RPS26 mRNA CTD PMID:15878706 NCBI chr 7:3,052,112...3,053,662 JBrowse link
G Rps6 ribosomal protein S6 increases expression ISO Buthionine Sulfoximine results in increased expression of RPS6 mRNA CTD PMID:15878706 NCBI chr 5:105,197,821...105,200,681
Ensembl chr 5:105,197,857...105,200,148
Ensembl chr 5:105,197,857...105,200,148
JBrowse link
G Rps7 ribosomal protein S7 increases expression ISO Buthionine Sulfoximine results in increased expression of RPS7 mRNA CTD PMID:15878706 NCBI chr 6:47,899,525...47,904,389
Ensembl chr 6:47,899,525...47,904,437
JBrowse link
G Rps8 ribosomal protein S8 increases expression ISO Buthionine Sulfoximine results in increased expression of RPS8 mRNA CTD PMID:15878706 NCBI chr 5:136,020,941...136,023,511
Ensembl chr 5:136,020,941...136,023,511
JBrowse link
G S100a8 S100 calcium binding protein A8 multiple interactions ISO
EXP
[Buthionine Sulfoximine co-treated with Lovastatin co-treated with Gemfibrozil] results in increased expression of S100A8 mRNA; [Phenytoin co-treated with Buthionine Sulfoximine] results in increased expression of S100A8 mRNA; [Pioglitazone co-treated with Buthionine Sulfoximine] results in increased expression of S100A8 mRNA
[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased expression of S100A8 mRNA; gadolinium chloride inhibits the reaction [[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased expression of S100A8 mRNA]
CTD PMID:23986454 PMID:26177832 PMID:28263783 PMID:30853469 NCBI chr 2:190,073,239...190,074,333
Ensembl chr 2:190,073,815...190,074,354
JBrowse link
G S100a9 S100 calcium binding protein A9 multiple interactions ISO
EXP
[Buthionine Sulfoximine co-treated with Lovastatin co-treated with Gemfibrozil] results in increased expression of S100A9 mRNA; [Phenytoin co-treated with Buthionine Sulfoximine] results in increased expression of S100A9 mRNA; [Pioglitazone co-treated with Buthionine Sulfoximine] results in increased expression of S100A9 mRNA; [zomepirac co-treated with Buthionine Sulfoximine co-treated with tri-o-cresyl phosphate] results in increased expression of S100A9 mRNA
[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased expression of S100A9 mRNA; gadolinium chloride inhibits the reaction [[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased expression of S100A9 mRNA]
CTD PMID:23986454 PMID:26177832 PMID:28263783 PMID:29154782 PMID:30853469 NCBI chr 2:190,097,436...190,100,209
Ensembl chr 2:190,097,554...190,100,276
JBrowse link
G Scarna15 small Cajal body-specific RNA 15 multiple interactions ISO [Methimazole co-treated with Buthionine Sulfoximine] results in increased expression of MIR1839 mRNA CTD PMID:27421576 NCBI chr 1:143,360,224...143,360,287
Ensembl chr 1:143,360,224...143,360,287
JBrowse link
G Sele selectin E multiple interactions ISO [Buthionine Sulfoximine results in decreased abundance of Glutathione] inhibits the reaction [TNF protein results in increased expression of SELE mRNA] CTD PMID:21971136 NCBI chr13:82,355,234...82,365,323
Ensembl chr13:82,355,471...82,365,341
JBrowse link
G Selenow selenoprotein W decreases expression
multiple interactions
ISO Buthionine Sulfoximine results in decreased expression of SELENOW mRNA
[Buthionine Sulfoximine results in decreased abundance of Glutathione] which results in decreased expression of SELENOW mRNA
CTD PMID:15823556 NCBI chr 1:77,530,692...77,535,765
Ensembl chr 1:77,533,148...77,535,681
Ensembl chr 1:77,533,148...77,535,681
JBrowse link
G Serpina3n serine (or cysteine) peptidase inhibitor, clade A, member 3N decreases expression ISO Buthionine Sulfoximine results in decreased expression of SERPINA3N mRNA CTD PMID:15707499 NCBI chr 6:128,073,344...128,080,878
Ensembl chr 6:127,941,526...128,080,889
JBrowse link
G Serpine1 serpin family E member 1 increases expression EXP Buthionine Sulfoximine results in increased expression of SERPINE1 mRNA CTD PMID:23939143 NCBI chr12:22,641,104...22,651,482
Ensembl chr12:22,641,104...22,651,482
JBrowse link
G Sesn2 sestrin 2 increases expression ISO Buthionine Sulfoximine results in increased expression of SESN2 protein CTD PMID:31323261 NCBI chr 5:150,684,891...150,703,846
Ensembl chr 5:150,684,133...150,704,117
JBrowse link
G Shank3 SH3 and multiple ankyrin repeat domains 3 decreases expression ISO Buthionine Sulfoximine results in decreased expression of SHANK3 mRNA CTD PMID:15878706 NCBI chr 7:130,474,278...130,534,679
Ensembl chr 7:130,474,279...130,534,679
JBrowse link
G Siah2 siah E3 ubiquitin protein ligase 2 decreases expression ISO Buthionine Sulfoximine results in decreased expression of SIAH2 mRNA CTD PMID:15878706 NCBI chr 2:148,874,151...148,891,900
Ensembl chr 2:148,874,151...148,891,900
JBrowse link
G Slc31a1 solute carrier family 31 member 1 multiple interactions ISO [Buthionine Sulfoximine results in decreased abundance of Glutathione] inhibits the reaction [SLC31A1 protein results in increased import of Copper]; Buthionine Sulfoximine inhibits the reaction [SLC31A1 protein results in increased import of Copper]; glutathione diethyl ester inhibits the reaction [Buthionine Sulfoximine inhibits the reaction [SLC31A1 protein results in increased import of Copper]] CTD PMID:23426973 NCBI chr 5:78,222,504...78,249,358
Ensembl chr 5:78,222,504...78,249,358
JBrowse link
G Snca synuclein alpha increases expression ISO Buthionine Sulfoximine results in increased expression of SNCA protein CTD PMID:15114628 NCBI chr 4:90,782,412...90,883,236
Ensembl chr 4:90,782,374...90,882,285
JBrowse link
G Snta1 syntrophin, alpha 1 decreases expression ISO Buthionine Sulfoximine results in decreased expression of SNTA1 mRNA CTD PMID:15878706 NCBI chr 3:149,874,023...149,905,980
Ensembl chr 3:149,874,030...149,905,944
JBrowse link
G Sod1 superoxide dismutase 1 increases expression ISO Buthionine Sulfoximine results in increased expression of SOD1 mRNA CTD PMID:15707499 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions
increases response to substance
ISO [Buthionine Sulfoximine co-treated with SOD2 protein] results in increased expression of MMP1 mRNA; Deferoxamine inhibits the reaction [[Buthionine Sulfoximine co-treated with SOD2 protein] results in increased expression of MMP1 mRNA]
Buthionine Sulfoximine affects the reaction [OGG1 protein affects the expression of SOD2 mRNA]
SOD2 protein results in increased susceptibility to Buthionine Sulfoximine
CTD PMID:8877099 PMID:10464329 PMID:15130278 PMID:32585298 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Sord sorbitol dehydrogenase multiple interactions ISO Buthionine Sulfoximine promotes the reaction [Diclofenac results in increased secretion of SORD protein] CTD PMID:12763371 NCBI chr 3:114,176,127...114,207,368
Ensembl chr 3:114,176,309...114,207,366
JBrowse link
G Sox4 SRY-box transcription factor 4 multiple interactions ISO [Methimazole co-treated with Buthionine Sulfoximine] results in decreased expression of SOX4 mRNA; [Methimazole co-treated with Buthionine Sulfoximine] results in decreased expression of SOX4 protein CTD PMID:27421576 NCBI chr17:37,615,022...37,619,728 JBrowse link
G Sp1 Sp1 transcription factor increases activity
multiple interactions
ISO Buthionine Sulfoximine results in increased activity of SP1 protein
mithramycin A inhibits the reaction [Buthionine Sulfoximine results in increased activity of SP1 protein]
CTD PMID:11261509 NCBI chr 7:144,014,173...144,044,635
Ensembl chr 7:144,014,173...144,044,629
JBrowse link
G Sp3 Sp3 transcription factor multiple interactions
increases activity
ISO mithramycin A inhibits the reaction [Buthionine Sulfoximine results in increased activity of SP3 protein] CTD PMID:11261509 NCBI chr 3:59,644,579...59,689,011
Ensembl chr 3:59,646,015...59,688,692
JBrowse link
G Spp1 secreted phosphoprotein 1 decreases expression ISO Buthionine Sulfoximine results in decreased expression of SPP1 mRNA CTD PMID:15707499 PMID:15878706 NCBI chr14:6,673,686...6,679,965
Ensembl chr14:6,673,686...6,679,901
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 decreases expression EXP Buthionine Sulfoximine results in decreased expression of SREBF1 mRNA CTD PMID:20482862 NCBI chr10:46,570,996...46,593,021
Ensembl chr10:46,570,996...46,593,009
JBrowse link
G Srebf2 sterol regulatory element binding transcription factor 2 multiple interactions ISO Buthionine Sulfoximine inhibits the reaction [Metformin inhibits the reaction [Hydrogen Peroxide results in increased cleavage of SREBF2 protein]]; Buthionine Sulfoximine promotes the reaction [Hydrogen Peroxide results in increased cleavage of SREBF2 protein] CTD PMID:29499335 NCBI chr 7:123,381,082...123,438,605
Ensembl chr 7:123,381,077...123,438,603
JBrowse link
G Srxn1 sulfiredoxin 1 increases expression ISO Buthionine Sulfoximine results in increased expression of SRXN1 protein CTD PMID:27358234 NCBI chr 3:147,608,850...147,614,410
Ensembl chr 3:147,609,095...147,632,801
JBrowse link
G Stat3 signal transducer and activator of transcription 3 increases activity
increases expression
EXP Buthionine Sulfoximine results in increased activity of STAT3 protein
Buthionine Sulfoximine results in increased expression of STAT3 mRNA
CTD PMID:11841787 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233
JBrowse link
G Syn1 synapsin I increases expression ISO Buthionine Sulfoximine results in increased expression of SYN1 mRNA CTD PMID:15878706 NCBI chr  X:1,321,315...1,379,202
Ensembl chr  X:1,321,315...1,379,198
JBrowse link
G Tbca tubulin folding cofactor A increases expression ISO Buthionine Sulfoximine results in increased expression of TBCA mRNA CTD PMID:15878706 NCBI chr 2:24,449,498...24,505,351
Ensembl chr 2:24,449,485...24,505,334
JBrowse link
G Tbx21 T-box transcription factor 21 multiple interactions ISO [Phenytoin co-treated with Buthionine Sulfoximine] results in decreased expression of TBX21 mRNA CTD PMID:23986454 NCBI chr10:85,032,799...85,049,331
Ensembl chr10:85,032,799...85,049,331
JBrowse link
G Tgfbr1 transforming growth factor, beta receptor 1 multiple interactions EXP Buthionine Sulfoximine inhibits the reaction [Acetylcysteine results in decreased expression of TGFBR1 mRNA]; Buthionine Sulfoximine inhibits the reaction [Acetylcysteine results in decreased expression of TGFBR1 protein]; Buthionine Sulfoximine inhibits the reaction [Curcumin results in decreased expression of TGFBR1 mRNA]; Buthionine Sulfoximine inhibits the reaction [Curcumin results in decreased expression of TGFBR1 protein] CTD PMID:17602960 NCBI chr 5:63,056,071...63,119,635
Ensembl chr 5:63,050,758...63,119,635
JBrowse link
G Tgfbr2 transforming growth factor, beta receptor 2 multiple interactions EXP Buthionine Sulfoximine inhibits the reaction [Acetylcysteine results in decreased expression of TGFBR2 mRNA]; Buthionine Sulfoximine inhibits the reaction [Acetylcysteine results in decreased expression of TGFBR2 protein]; Buthionine Sulfoximine inhibits the reaction [Curcumin results in decreased expression of TGFBR2 mRNA]; Buthionine Sulfoximine inhibits the reaction [Curcumin results in decreased expression of TGFBR2 protein] CTD PMID:17602960 NCBI chr 8:124,310,288...124,399,345
Ensembl chr 8:124,312,754...124,399,494
JBrowse link
G Thrsp thyroid hormone responsive decreases expression EXP Buthionine Sulfoximine results in decreased expression of THRSP mRNA CTD PMID:20482862 NCBI chr 1:162,381,251...162,385,575
Ensembl chr 1:162,381,253...162,385,575
JBrowse link
G Tinf2 TERF1 interacting nuclear factor 2 increases expression ISO Buthionine Sulfoximine results in increased expression of TINF2 mRNA CTD PMID:15878706 NCBI chr15:34,358,697...34,365,085
Ensembl chr15:34,360,974...34,364,081
JBrowse link
G Tle5 TLE family member 5, transcriptional modulator increases expression ISO Buthionine Sulfoximine results in increased expression of TLE5 mRNA CTD PMID:15878706 NCBI chr 7:11,012,843...11,018,156
Ensembl chr 7:11,013,681...11,018,160
JBrowse link
G Tlr2 toll-like receptor 2 multiple interactions ISO [Phenytoin co-treated with Buthionine Sulfoximine] results in increased expression of TLR2 mRNA CTD PMID:23986454 NCBI chr 2:182,840,171...182,846,061
Ensembl chr 2:182,840,727...182,846,061
JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions ISO
EXP
[Phenytoin co-treated with Buthionine Sulfoximine] results in decreased expression of TLR4 mRNA
[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased expression of TLR4 protein; gadolinium chloride inhibits the reaction [[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased expression of TLR4 protein]
CTD PMID:23986454 PMID:26177832 NCBI chr 5:82,587,424...82,601,056
Ensembl chr 5:82,587,420...82,601,052
JBrowse link
G Tlr9 toll-like receptor 9 multiple interactions ISO [Phenytoin co-treated with Buthionine Sulfoximine] results in decreased expression of TLR9 mRNA CTD PMID:23986454 NCBI chr 8:114,916,122...114,920,171
Ensembl chr 8:114,916,122...114,920,171
JBrowse link
G Tmsb10 thymosin, beta 10 increases expression ISO Buthionine Sulfoximine results in increased expression of TMSB10 mRNA CTD PMID:15707499 NCBI chr 4:100,882,216...100,883,303
Ensembl chr 4:100,882,216...100,883,275
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases secretion
ISO
EXP
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[Buthionine Sulfoximine results in decreased abundance of Glutathione] which results in decreased susceptibility to TNF protein]; [[Buthionine Sulfoximine results in decreased abundance of Glutathione] which co-treated with arsenite] inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]; [Buthionine Sulfoximine results in decreased abundance of Glutathione] inhibits the reaction [TNF protein results in increased expression of SELE mRNA]; [Buthionine Sulfoximine results in decreased abundance of Glutathione] inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]; [Buthionine Sulfoximine results in decreased abundance of Glutathione] which results in decreased susceptibility to TNF protein; Acetylcysteine inhibits the reaction [Buthionine Sulfoximine results in increased secretion of TNF protein]; Buthionine Sulfoximine inhibits the reaction [carnosol inhibits the reaction [TNF protein affects the localization of RELA protein]]; Buthionine Sulfoximine inhibits the reaction [carnosol inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]]; Buthionine Sulfoximine inhibits the reaction [cinnamic aldehyde inhibits the reaction [TNF protein affects the localization of RELA protein]]; Buthionine Sulfoximine inhibits the reaction [cinnamic aldehyde inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]]; Buthionine Sulfoximine promotes the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Buthionine Sulfoximine promotes the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; Buthionine Sulfoximine promotes the reaction [TNF protein results in increased expression of CCL5 protein]; SB 203580 inhibits the reaction [Buthionine Sulfoximine promotes the reaction [TNF protein results in increased expression of CCL5 protein]]; TNF protein inhibits the reaction [[Buthionine Sulfoximine results in decreased abundance of Glutathione] which results in increased expression of HMOX1 mRNA]; TNF protein inhibits the reaction [[Buthionine Sulfoximine results in decreased abundance of Glutathione] which results in increased expression of NQO1 mRNA]
[pioglitazone co-treated with Buthionine Sulfoximine] results in increased expression of TNF mRNA; Buthionine Sulfoximine inhibits the reaction [manganese chloride promotes the reaction [Lipopolysaccharides results in increased expression of TNF protein]]
[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased expression of TNF mRNA; [Carmustine co-treated with Buthionine Sulfoximine] inhibits the reaction [TNF protein results in increased expression of NOS2 protein]; Acetylcysteine inhibits the reaction [[Buthionine Sulfoximine co-treated with Lipopolysaccharides] results in increased secretion of TNF protein]; Acetylcysteine inhibits the reaction [Buthionine Sulfoximine results in increased secretion of TNF protein]; Buthionine Sulfoximine inhibits the reaction [TNF protein results in increased expression of NOS2 mRNA]; Buthionine Sulfoximine promotes the reaction [Carmustine inhibits the reaction [TNF protein results in increased expression of NOS2 mRNA]]; Buthionine Sulfoximine promotes the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; Nitrites inhibits the reaction [[TNF protein results in increased activity of NOS2 protein] which results in increased chemical synthesis of Buthionine Sulfoximine]
CTD PMID:7532384 PMID:11167962 PMID:11970852 PMID:12433058 PMID:15601679 PMID:16271621 PMID:18755394 PMID:20116392 PMID:20351055 PMID:21971136 PMID:26177832 PMID:28263783 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Top2b DNA topoisomerase II beta decreases expression ISO Buthionine Sulfoximine results in decreased expression of TOP2B mRNA CTD PMID:15707499 NCBI chr15:10,262,972...10,319,741
Ensembl chr15:10,262,651...10,320,233
JBrowse link
G Tp53 tumor protein p53 multiple interactions
increases expression
ISO
EXP
[Buthionine Sulfoximine results in decreased abundance of Glutathione] inhibits the reaction [Benzo(a)pyrene results in increased activity of TP53 protein]
[cyanoginosin LR co-treated with Buthionine Sulfoximine] results in increased expression of TP53 protein
Buthionine Sulfoximine results in increased expression of TRP53 protein
CTD PMID:12807757 PMID:18552690 PMID:25410294 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Tpi1 triosephosphate isomerase 1 increases expression EXP Buthionine Sulfoximine results in increased expression of TPI1 protein CTD PMID:23736079 NCBI chr 4:157,328,375...157,331,905
Ensembl chr 4:157,328,379...157,331,905
Ensembl chr 9:157,328,379...157,331,905
JBrowse link
G Trap1 TNF receptor-associated protein 1 increases expression EXP Buthionine Sulfoximine results in increased expression of TRAP1 protein CTD PMID:23736079 NCBI chr10:11,724,032...11,757,682
Ensembl chr10:11,724,032...11,757,681
JBrowse link
G Trpm2 transient receptor potential cation channel, subfamily M, member 2 multiple interactions ISO 4-amylcinnamoylanthranilic acid inhibits the reaction [[Buthionine Sulfoximine co-treated with Adenosine Diphosphate Ribose] results in increased activity of TRPM2 protein]; [Buthionine Sulfoximine co-treated with Adenosine Diphosphate Ribose] results in increased activity of TRPM2 protein; Glutathione inhibits the reaction [[Buthionine Sulfoximine co-treated with Adenosine Diphosphate Ribose] results in increased activity of TRPM2 protein] CTD PMID:33309544 NCBI chr20:11,434,062...11,482,880
Ensembl chr20:11,436,267...11,482,051
JBrowse link
G Trpv4 transient receptor potential cation channel, subfamily V, member 4 multiple interactions EXP [Gadolinium results in decreased activity of TRPV4 protein] which results in decreased susceptibility to Buthionine Sulfoximine; [Ruthenium Red results in decreased activity of TRPV4 protein] which results in decreased susceptibility to Buthionine Sulfoximine CTD PMID:20064552 NCBI chr12:47,698,915...47,737,902
Ensembl chr12:47,698,947...47,737,902
JBrowse link
G Txn1 thioredoxin 1 increases expression
multiple interactions
ISO Buthionine Sulfoximine results in increased expression of TXN1 mRNA
NGF protein affects the reaction [Buthionine Sulfoximine results in increased expression of TXN1 mRNA]
CTD PMID:23472850 NCBI chr 5:75,049,735...75,057,731
Ensembl chr 5:75,049,747...75,057,752
JBrowse link
G Txnrd1 thioredoxin reductase 1 multiple interactions
increases response to substance
increases expression
ISO
EXP
Buthionine Sulfoximine inhibits the reaction [sulforaphane results in increased expression of TXNRD1 mRNA]; Buthionine Sulfoximine promotes the reaction [Sodium Selenite results in increased activity of TXNRD1 protein]
TXNRD1 gene mutant form results in increased susceptibility to Buthionine Sulfoximine
Buthionine Sulfoximine results in increased expression of TXNRD1 mRNA
[Carmustine co-treated with Buthionine Sulfoximine] results in decreased activity of TXNRD1 protein
CTD PMID:12663510 PMID:16288907 PMID:19010381 PMID:24853413 NCBI chr 7:26,946,124...26,984,400
Ensembl chr 7:26,946,125...26,984,400
JBrowse link
G U2af2 U2 small nuclear RNA auxiliary factor 2 increases expression EXP Buthionine Sulfoximine results in increased expression of U2AF2 protein CTD PMID:23736079 NCBI chr 1:72,312,260...72,329,828
Ensembl chr 1:72,312,727...72,329,856
JBrowse link
G Ubc ubiquitin C increases expression ISO Buthionine Sulfoximine results in increased expression of UBC mRNA CTD PMID:15878706 NCBI chr12:36,638,457...36,642,734
Ensembl chr12:36,638,457...36,642,734
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO [[Buthionine Sulfoximine results in decreased abundance of Glutathione] which co-treated with arsenite] inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]; [Buthionine Sulfoximine results in decreased abundance of Glutathione] inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA] CTD PMID:16271621 PMID:21971136 NCBI chr 2:219,071,193...219,090,931
Ensembl chr 2:219,071,193...219,097,619
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO Buthionine Sulfoximine promotes the reaction [sodium arsenite results in increased expression of VEGFA mRNA] CTD PMID:11641398 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
G Vps26c VPS26 endosomal protein sorting factor C decreases expression ISO Buthionine Sulfoximine results in decreased expression of VPS26C mRNA CTD PMID:15878706 NCBI chr11:34,764,053...34,792,446
Ensembl chr11:34,764,721...34,791,993
JBrowse link
G Xirp1 xin actin-binding repeat containing 1 multiple interactions ISO [Buthionine Sulfoximine co-treated with Atorvastatin co-treated with Ciprofloxacin] results in increased expression of XIRP1 mRNA CTD PMID:29679711 NCBI chr 8:128,694,809...128,712,092
Ensembl chr 8:128,702,133...128,711,221
JBrowse link
G Zfp422 zinc finger protein 422 decreases expression ISO Buthionine Sulfoximine results in decreased expression of ZFP422 mRNA CTD PMID:15878706 NCBI chr 4:148,757,362...148,761,594
Ensembl chr 4:148,757,363...148,761,547
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19771
    role 19716
      application 19406
        refrigerant 17478
          ammonia 17016
            organic amino compound 17015
              amino acid 14113
                alpha-amino acid 11600
                  non-proteinogenic alpha-amino acid 1563
                    homocysteines 398
                      S-(5-deoxy-D-ribos-5-yl)-L-homocysteine + 0
                      S-adenosyl-L-homocysteine 23
                      S-butyl-DL-homocysteine (S,R)-sulfoximine 314
                      S-inosyl-L-homocysteine 0
                      cystathionines + 3
                      homocysteine + 123
Path 2
Term Annotations click to browse term
  CHEBI ontology 19771
    subatomic particle 19770
      composite particle 19770
        hadron 19770
          baryon 19770
            nucleon 19770
              atomic nucleus 19770
                atom 19770
                  main group element atom 19658
                    p-block element atom 19658
                      carbon group element atom 19574
                        carbon atom 19564
                          organic molecular entity 19564
                            organic group 18599
                              organic divalent group 18590
                                organodiyl group 18590
                                  carbonyl group 18505
                                    carbonyl compound 18505
                                      carboxylic acid 18157
                                        amino acid 14113
                                          alpha-amino acid 11600
                                            non-proteinogenic alpha-amino acid 1563
                                              homocysteines 398
                                                S-(5-deoxy-D-ribos-5-yl)-L-homocysteine + 0
                                                S-adenosyl-L-homocysteine 23
                                                S-butyl-DL-homocysteine (S,R)-sulfoximine 314
                                                S-inosyl-L-homocysteine 0
                                                cystathionines + 3
                                                homocysteine + 123
paths to the root