CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: hexahydroxyflavone
Accession: CHEBI:24561
browse the term
Definition: Members of the class of hydroxyflavone that is flavone substituted by 6 hydroxy groups.
Synonyms: related_synonym: hexahydroxyflavones
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Mapk1
mitogen activated protein kinase 1
multiple interactions
EXP
ampelopsin analog inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in increased phosphorylation of MAPK1 protein]
CTD
PMID:21871475
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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Mapk3
mitogen activated protein kinase 3
multiple interactions
EXP
ampelopsin analog inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in increased phosphorylation of MAPK3 protein]
CTD
PMID:21871475
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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Pdgfb
platelet derived growth factor subunit B
multiple interactions
EXP
ampelopsin analog inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in increased phosphorylation of MAPK1 protein]; ampelopsin analog inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in increased phosphorylation of MAPK3 protein]; ampelopsin analog inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in increased phosphorylation of PDGFRB protein]; ampelopsin analog inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in increased phosphorylation of PLCG1 protein]
CTD
PMID:21871475
NCBI chr 7:111,539,444...111,557,984
Ensembl chr 7:111,540,345...111,557,984
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Pdgfrb
platelet derived growth factor receptor beta
multiple interactions
EXP
ampelopsin analog inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in increased phosphorylation of PDGFRB protein]
CTD
PMID:21871475
NCBI chr18:54,499,962...54,538,840
Ensembl chr18:54,499,964...54,538,843
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Plcg1
phospholipase C, gamma 1
multiple interactions
EXP
ampelopsin analog inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in increased phosphorylation of PLCG1 protein]
CTD
PMID:21871475
NCBI chr 3:149,385,587...149,416,330
Ensembl chr 3:149,385,587...149,416,330
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Sphk1
sphingosine kinase 1
decreases expression decreases activity
ISO
ampelopsin results in decreased expression of SPHK1 protein ampelopsin results in decreased activity of SPHK1 protein
CTD
PMID:22251058
NCBI chr10:101,758,567...101,764,240
Ensembl chr10:101,758,711...101,764,240
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Abcc5
ATP binding cassette subfamily C member 5
increases expression
ISO
casticin results in increased expression of ABCC5 mRNA
CTD
PMID:28444820
NCBI chr11:80,473,809...80,567,257
Ensembl chr11:80,473,872...80,567,253
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Adam10
ADAM metallopeptidase domain 10
increases expression
ISO
casticin results in increased expression of ADAM10 mRNA
CTD
PMID:28444820
NCBI chr 8:71,346,008...71,477,889
Ensembl chr 8:71,345,837...71,477,889
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Aftph
aftiphilin
decreases expression
ISO
casticin results in decreased expression of AFTPH mRNA
CTD
PMID:28444820
NCBI chr14:94,871,429...94,925,625
Ensembl chr14:94,871,429...94,925,376
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Agap1
ArfGAP with GTPase domain, ankyrin repeat and PH domain 1
decreases expression
ISO
casticin results in decreased expression of AGAP1 mRNA
CTD
PMID:28444820
NCBI chr 9:90,039,720...90,475,196
Ensembl chr 9:90,039,605...90,470,958
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Aifm1
apoptosis inducing factor, mitochondria associated 1
increases expression multiple interactions
ISO
casticin results in increased expression of AIFM1 protein [Fluorouracil co-treated with casticin] results in increased expression of AIFM1 protein
CTD
PMID:29098808 PMID:32270916
NCBI chr X:127,650,223...127,689,356
Ensembl chr X:127,650,226...127,689,256
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Akirin2
akirin 2
decreases expression
ISO
casticin results in decreased expression of AKIRIN2 mRNA
CTD
PMID:28444820
NCBI chr 5:49,108,231...49,122,566
Ensembl chr 5:49,108,220...49,122,568
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Akt1
AKT serine/threonine kinase 1
decreases expression
ISO
casticin results in decreased expression of AKT1 protein
CTD
PMID:28444820
NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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Akt3
AKT serine/threonine kinase 3
decreases expression
ISO
casticin results in decreased expression of AKT3 mRNA
CTD
PMID:27862857
NCBI chr13:88,943,708...89,225,831
Ensembl chr13:88,946,091...89,225,708
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Aldh1a1
aldehyde dehydrogenase 1 family, member A1
increases expression
ISO
casticin results in increased expression of ALDH1A1 mRNA
CTD
PMID:27862857
NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961
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Alx1
ALX homeobox 1
decreases expression
ISO
casticin results in decreased expression of ALX1 mRNA
CTD
PMID:28444820
NCBI chr 7:38,157,626...38,177,220
Ensembl chr 7:38,147,117...38,177,220
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Apaf1
apoptotic peptidase activating factor 1
increases expression
ISO
casticin results in increased expression of APAF1 protein
CTD
PMID:27862857
NCBI chr 7:25,494,143...25,579,540
Ensembl chr 7:25,494,609...25,579,540
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Arl6ip4
ADP-ribosylation factor like GTPase 6 interacting protein 4
decreases expression
ISO
casticin results in decreased expression of ARL6IP4 mRNA
CTD
PMID:28444820
NCBI chr12:32,479,623...32,481,768
Ensembl chr12:32,479,625...32,481,799
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Armc9
armadillo repeat containing 9
decreases expression
ISO
casticin results in decreased expression of ARMC9 mRNA
CTD
PMID:28444820
NCBI chr 9:86,802,791...86,928,611
Ensembl chr 9:86,802,868...86,928,860
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Arpc5l
actin related protein 2/3 complex, subunit 5-like
decreases expression
ISO
casticin results in decreased expression of ARPC5L mRNA
CTD
PMID:28444820
NCBI chr 3:22,758,710...22,767,520
Ensembl chr 3:22,759,876...22,767,538 Ensembl chr 9:22,759,876...22,767,538
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Asns
asparagine synthetase (glutamine-hydrolyzing)
decreases expression
ISO
casticin results in decreased expression of ASNS mRNA
CTD
PMID:28444820
NCBI chr 4:35,784,995...35,803,474
Ensembl chr 4:35,785,237...35,803,423
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Atf5
activating transcription factor 5
decreases expression
ISO
casticin results in decreased expression of ATF5 mRNA
CTD
PMID:28444820
NCBI chr 1:95,295,602...95,299,755
Ensembl chr 1:95,295,610...95,299,707
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Atf6
activating transcription factor 6
increases expression
ISO
casticin results in increased expression of ATF6 protein
CTD
PMID:27862857
NCBI chr13:82,927,579...83,106,381
Ensembl chr13:82,930,034...83,107,177
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Atm
ATM serine/threonine kinase
decreases expression
ISO
casticin results in decreased expression of ATM protein
CTD
PMID:29098808
NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437
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Atox1
antioxidant 1 copper chaperone
increases expression
ISO
casticin results in increased expression of ATOX1 mRNA
CTD
PMID:28444820
NCBI chr10:39,564,855...39,579,892
Ensembl chr10:39,564,857...39,579,950
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Atp6v1g1
ATPase H+ transporting V1 subunit G1
decreases expression
ISO
casticin results in decreased expression of ATP6V1G1 mRNA
CTD
PMID:28444820
NCBI chr 5:76,961,462...76,967,642
Ensembl chr 5:76,961,499...76,969,463
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Atp8a1
ATPase phospholipid transporting 8A1
increases expression
ISO
casticin results in increased expression of ATP8A1 mRNA
CTD
PMID:28444820
NCBI chr14:40,315,013...40,557,572
Ensembl chr14:40,315,049...40,554,611
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Atr
ATR serine/threonine kinase
decreases expression
ISO
casticin results in decreased expression of ATR protein
CTD
PMID:29098808
NCBI chr 8:96,426,704...96,524,152
Ensembl chr 8:96,426,724...96,524,136
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Atxn7l3b
ataxin 7-like 3B
decreases expression
ISO
casticin results in decreased expression of ATXN7L3B mRNA
CTD
PMID:28444820
NCBI chr 7:48,322,451...48,325,975
Ensembl chr 7:48,321,755...48,328,878
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Avpr1a
arginine vasopressin receptor 1A
decreases expression
ISO
casticin results in decreased expression of AVPR1A mRNA
CTD
PMID:28444820
NCBI chr 7:58,114,306...58,118,230
Ensembl chr 7:58,114,284...58,122,215
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Axin2
axin 2
increases expression
ISO
casticin results in increased expression of AXIN2 mRNA
CTD
PMID:27862857
NCBI chr10:93,893,830...93,927,042
Ensembl chr10:93,899,245...93,926,231
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Bak1
BCL2-antagonist/killer 1
increases expression
ISO
casticin results in increased expression of BAK1 protein
CTD
PMID:27862857
NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264
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Bambi
BMP and activin membrane-bound inhibitor
increases expression
ISO
casticin results in increased expression of BAMBI mRNA
CTD
PMID:27862857
NCBI chr17:54,121,251...54,125,816
Ensembl chr17:54,121,255...54,126,060
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Basp1
brain abundant, membrane attached signal protein 1
decreases expression
ISO
casticin results in decreased expression of BASP1 mRNA
CTD
PMID:28444820
NCBI chr 2:75,816,130...75,863,801
Ensembl chr 2:75,816,122...75,864,043
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Bax
BCL2 associated X, apoptosis regulator
increases expression multiple interactions
ISO
casticin results in increased expression of BAX protein casticin inhibits the reaction [Fluorouracil results in increased expression of BAX protein]
CTD
PMID:27862857 PMID:29098808 PMID:32270916
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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Bcl11a
BCL11 transcription factor A
decreases expression
ISO
casticin results in decreased expression of BCL11A mRNA
CTD
PMID:28444820
NCBI chr14:98,029,018...98,124,181
Ensembl chr14:98,030,461...98,124,180
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Bcl2
BCL2, apoptosis regulator
decreases expression multiple interactions
ISO
casticin results in decreased expression of BCL2 protein [Fluorouracil co-treated with casticin] results in decreased expression of BCL2 protein
CTD
PMID:27862857 PMID:29098808 PMID:32270916
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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Bcl2l1
Bcl2-like 1
decreases expression multiple interactions increases expression
ISO
casticin results in decreased expression of BCL2L1 protein casticin promotes the reaction [Fluorouracil results in decreased expression of BCL2L1 protein]; Fluorouracil promotes the reaction [casticin results in decreased expression of BCL2L1 protein] casticin results in increased expression of BCL2L1 mRNA
CTD
PMID:27862857 PMID:29098808 PMID:32270916
NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
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Bid
BH3 interacting domain death agonist
increases expression multiple interactions decreases expression
ISO
casticin results in increased expression of BID protein casticin inhibits the reaction [Fluorouracil results in increased expression of BID protein] casticin results in decreased expression of BID protein
CTD
PMID:27862857 PMID:29098808 PMID:32270916
NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720
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Bmal1
basic helix-loop-helix ARNT like 1
decreases expression
ISO
casticin results in decreased expression of BMAL1 mRNA
CTD
PMID:28444820
NCBI chr 1:167,331,756...167,430,235
Ensembl chr 1:167,331,633...167,430,231
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Bmi1
BMI1 proto-oncogene, polycomb ring finger
multiple interactions decreases expression
ISO
casticin promotes the reaction [MIR148A mRNA results in decreased expression of BMI1 mRNA]; DNMT1 protein inhibits the reaction [casticin results in decreased expression of BMI1 protein]; MIR148A mRNA promotes the reaction [casticin results in decreased expression of BMI1 mRNA]
CTD
PMID:32268151
NCBI chr17:81,332,175...81,341,625
Ensembl chr17:81,332,214...81,388,690
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Bmp4
bone morphogenetic protein 4
increases expression
ISO
casticin results in increased expression of BMP4 mRNA
CTD
PMID:27862857
NCBI chr15:19,618,538...19,633,494
Ensembl chr15:19,618,542...19,623,306
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Bnip2
BCL2 interacting protein 2
decreases expression
ISO
casticin results in decreased expression of BNIP2 mRNA
CTD
PMID:27862857
NCBI chr 8:70,640,436...70,661,782
Ensembl chr 8:70,640,445...70,675,590
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Brca1
BRCA1, DNA repair associated
increases expression
ISO
casticin results in increased expression of BRCA1 protein
CTD
PMID:29098808
NCBI chr10:86,417,441...86,477,762
Ensembl chr10:86,418,000...86,477,304
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Btf3
basic transcription factor 3
decreases expression
ISO
casticin results in decreased expression of BTF3 mRNA
CTD
PMID:28444820
NCBI chr 2:29,659,764...29,666,898
Ensembl chr 2:29,659,231...29,666,879
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Btg1
BTG anti-proliferation factor 1
decreases expression
ISO
casticin results in decreased expression of BTG1 mRNA
CTD
PMID:28444820
NCBI chr 7:31,341,391...31,343,649
Ensembl chr 7:31,341,027...31,343,649
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Cadm1
cell adhesion molecule 1
increases expression
ISO
casticin results in increased expression of CADM1 mRNA
CTD
PMID:28444820
NCBI chr 8:47,847,836...48,178,703
Ensembl chr 8:47,847,325...48,182,833
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Calcoco1
calcium binding and coiled coil domain 1
decreases expression
ISO
casticin results in decreased expression of CALCOCO1 mRNA
CTD
PMID:28444820
NCBI chr 7:133,834,705...133,849,515
Ensembl chr 7:133,834,707...133,849,422
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Calm1
calmodulin 1
decreases expression
ISO
casticin results in decreased expression of CALM1 mRNA
CTD
PMID:28444820
NCBI chr 6:119,487,691...119,495,759
Ensembl chr 6:119,487,621...119,498,227
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Camk4
calcium/calmodulin-dependent protein kinase IV
decreases expression
ISO
casticin results in decreased expression of CAMK4 mRNA
CTD
PMID:27862857
NCBI chr18:24,582,988...24,811,918
Ensembl chr18:24,585,269...24,802,487
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Capn1
calpain 1
multiple interactions
ISO
casticin results in increased expression of and results in increased cleavage of CAPN1 protein
CTD
PMID:27862857
NCBI chr 1:203,275,912...203,300,848
Ensembl chr 1:203,277,344...203,300,177
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Capn2
calpain 2
increases expression
ISO
casticin results in increased expression of CAPN2 protein
CTD
PMID:27862857
NCBI chr13:94,150,244...94,200,969
Ensembl chr13:94,150,240...94,200,969
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Casp2
caspase 2
increases expression
ISO
casticin results in increased expression of CASP2 protein
CTD
PMID:27862857
NCBI chr 4:71,149,632...71,167,388
Ensembl chr 4:71,149,669...71,167,379
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Casp3
caspase 3
multiple interactions increases activity
ISO
casticin results in increased cleavage of and results in increased activity of CASP3 protein casticin inhibits the reaction [Fluorouracil results in increased activity of CASP3 protein] casticin results in increased activity of CASP3 protein
CTD
PMID:27862857 PMID:29098808 PMID:32270916
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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Casp4
caspase 4
increases expression
ISO
casticin results in increased expression of CASP4 protein
CTD
PMID:27862857
NCBI chr 8:2,599,017...2,635,097
Ensembl chr 8:2,598,876...2,635,092
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Casp6
caspase 6
increases expression
ISO
casticin results in increased expression of CASP6 protein
CTD
PMID:27862857
NCBI chr 2:218,466,063...218,478,503
Ensembl chr 2:218,466,076...218,478,502
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Casp7
caspase 7
increases expression
ISO
casticin results in increased expression of CASP7 protein
CTD
PMID:27862857
NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729
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Casp8
caspase 8
multiple interactions
ISO
casticin results in increased cleavage of and results in increased activity of CASP8 protein; casticin results in increased expression of and results in increased activity of CASP8 protein
CTD
PMID:27862857 PMID:29098808
NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
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Casp9
caspase 9
multiple interactions increases activity
ISO
casticin results in increased cleavage of and results in increased activity of CASP9 protein casticin promotes the reaction [Fluorouracil results in increased activity of CASP9 protein] casticin results in increased activity of CASP9 protein
CTD
PMID:27862857 PMID:29098808 PMID:32270916
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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Cat
catalase
increases expression multiple interactions
ISO
casticin results in increased expression of CAT protein Fluorouracil inhibits the reaction [casticin results in increased expression of CAT protein]
CTD
PMID:32270916
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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Ccdc122
coiled-coil domain containing 122
increases expression
ISO
casticin results in increased expression of CCDC122 mRNA
CTD
PMID:28444820
NCBI chr15:52,407,717...52,470,163
Ensembl chr15:52,407,717...52,470,163
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Ccdc174
coiled-coil domain containing 174
decreases expression
ISO
casticin results in decreased expression of CCDC174 mRNA
CTD
PMID:28444820
NCBI chr 4:124,392,183...124,419,035
Ensembl chr 4:124,392,274...124,419,035
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Ccdc90b
coiled-coil domain containing 90B
decreases expression
ISO
casticin results in decreased expression of CCDC90B mRNA
CTD
PMID:28444820
NCBI chr 1:146,632,756...146,646,314
Ensembl chr 1:146,633,036...146,647,338
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Ccn1
cellular communication network factor 1
increases expression
ISO
casticin results in increased expression of CCN1 mRNA
CTD
PMID:28444820
NCBI chr 2:234,562,410...234,565,370
Ensembl chr 2:234,562,408...234,565,484
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Ccnb1
cyclin B1
decreases expression
ISO
casticin results in decreased expression of CCNB1 protein
CTD
PMID:29098808
NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172
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Cct4
chaperonin containing TCP1 subunit 4
decreases expression
ISO
casticin results in decreased expression of CCT4 mRNA
CTD
PMID:28444820
NCBI chr14:96,991,853...97,004,732
Ensembl chr14:96,991,859...97,005,267
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Cd24
CD24 molecule
increases expression
ISO
casticin results in increased expression of CD24 mRNA
CTD
PMID:27862857
NCBI chr20:47,074,353...47,079,662
Ensembl chr20:47,073,512...47,079,662
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Cd44
CD44 molecule
decreases expression multiple interactions
ISO
casticin results in decreased expression of CD44 mRNA; casticin results in decreased expression of CD44 protein casticin affects the reaction [MIR148A mRNA affects the expression of CD44 mRNA]; casticin promotes the reaction [MIR148A mRNA results in decreased expression of CD44 protein]; DNMT1 protein inhibits the reaction [casticin results in decreased expression of CD44 protein]; MIR148A mRNA promotes the reaction [casticin results in decreased expression of CD44 protein]
CTD
PMID:32268151
NCBI chr 3:89,155,850...89,244,615
Ensembl chr 3:89,157,058...89,244,620
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Cd83
CD83 molecule
decreases expression
ISO
casticin results in decreased expression of CD83 mRNA
CTD
PMID:27862857
NCBI chr17:20,887,309...20,907,009
Ensembl chr17:20,887,309...20,907,083
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Cdc25c
cell division cycle 25C
decreases expression
ISO
casticin results in decreased expression of CDC25C protein
CTD
PMID:29098808
NCBI chr18:26,335,156...26,356,199
Ensembl chr18:26,335,834...26,356,185
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Cdc42
cell division cycle 42
decreases expression
ISO
casticin results in decreased expression of CDC42 mRNA
CTD
PMID:28444820
NCBI chr 5:149,555,069...149,593,239
Ensembl chr 5:149,553,724...149,593,111
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Cdh17
cadherin 17
increases expression
ISO
casticin results in increased expression of CDH17 mRNA
CTD
PMID:27862857
NCBI chr 5:25,262,820...25,314,884
Ensembl chr 5:25,262,758...25,314,884
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Cdk2
cyclin dependent kinase 2
increases expression
ISO
casticin results in increased expression of CDK2 protein
CTD
PMID:29098808
NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403
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Cdkn1a
cyclin-dependent kinase inhibitor 1A
decreases expression
ISO
casticin results in decreased expression of CDKN1A mRNA; casticin results in decreased expression of CDKN1A protein
CTD
PMID:27862857 PMID:29098808
NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
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Cdkn1b
cyclin-dependent kinase inhibitor 1B
increases expression
ISO
casticin results in increased expression of CDKN1B mRNA
CTD
PMID:27862857
NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982
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Cdkn2a
cyclin-dependent kinase inhibitor 2A
increases expression
ISO
casticin results in increased expression of CDKN2A protein
CTD
PMID:29098808
NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149
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Chek2
checkpoint kinase 2
increases expression
ISO
casticin results in increased expression of CHEK2 protein
CTD
PMID:29098808
NCBI chr12:45,788,823...45,821,382
Ensembl chr12:45,788,827...45,821,286
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Chic2
cysteine-rich hydrophobic domain 2
decreases expression
ISO
casticin results in decreased expression of CHIC2 mRNA
CTD
PMID:28444820
NCBI chr14:33,157,669...33,192,015
Ensembl chr14:33,157,537...33,191,895
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Cldn1
claudin 1
decreases expression
ISO
casticin results in decreased expression of CLDN1 mRNA
CTD
PMID:27862857
NCBI chr11:74,421,569...74,436,728
Ensembl chr11:74,421,569...74,436,724
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Cnbp
CCHC-type zinc finger, nucleic acid binding protein
decreases expression
ISO
casticin results in decreased expression of CNBP mRNA
CTD
PMID:28444820
NCBI chr 4:120,302,768...120,311,694
Ensembl chr 4:120,302,771...120,311,637
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Col1a1
collagen type I alpha 1 chain
decreases expression
ISO
casticin results in decreased expression of COL1A1 mRNA
CTD
PMID:27862857
NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
G
Cpe
carboxypeptidase E
increases expression
ISO
casticin results in increased expression of CPE mRNA
CTD
PMID:28444820
NCBI chr16:25,030,276...25,142,231
Ensembl chr16:25,030,276...25,142,233
G
Creb1
cAMP responsive element binding protein 1
increases expression
ISO
casticin results in increased expression of CREB1 mRNA
CTD
PMID:27862857
NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
G
Crhbp
corticotropin releasing hormone binding protein
decreases expression
ISO
casticin results in decreased expression of CRHBP mRNA
CTD
PMID:28444820
NCBI chr 2:26,692,403...26,704,710
Ensembl chr 2:26,692,403...26,704,710
G
Crls1
cardiolipin synthase 1
decreases expression
ISO
casticin results in decreased expression of CRLS1 mRNA
CTD
PMID:28444820
NCBI chr 3:120,119,822...120,138,674
Ensembl chr 3:120,119,852...120,138,655
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Cryab
crystallin, alpha B
increases expression
ISO
casticin results in increased expression of CRYAB mRNA
CTD
PMID:28444820
NCBI chr 8:51,093,441...51,099,161
Ensembl chr 8:51,093,441...51,099,157
G
Csnk1a1
casein kinase 1, alpha 1
decreases expression
ISO
casticin results in decreased expression of CSNK1A1 mRNA
CTD
PMID:28444820
NCBI chr18:55,017,049...55,050,184
Ensembl chr18:55,017,055...55,049,271
G
Cyb5r1
cytochrome b5 reductase 1
decreases expression
ISO
casticin results in decreased expression of CYB5R1 mRNA
CTD
PMID:28444820
NCBI chr13:45,849,017...45,855,458
Ensembl chr13:45,849,091...45,855,458
G
Cycs
cytochrome c, somatic
increases expression
ISO
casticin results in increased expression of CYCS protein
CTD
PMID:27862857 PMID:29098808
NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054 Ensembl chr18:79,651,378...79,654,054
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Ddit3
DNA-damage inducible transcript 3
decreases expression
ISO
casticin results in decreased expression of DDIT3 mRNA
CTD
PMID:28444820
NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
G
Ddx27
DEAD-box helicase 27
decreases expression
ISO
casticin results in decreased expression of DDX27 mRNA
CTD
PMID:28444820
NCBI chr 3:155,744,182...155,763,380
Ensembl chr 3:155,744,150...155,763,372
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Dip2c
disco-interacting protein 2 homolog C
decreases expression
ISO
casticin results in decreased expression of DIP2C mRNA
CTD
PMID:28444820
NCBI chr17:60,647,346...61,032,467
Ensembl chr17:60,649,065...61,032,305
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Dkk3
dickkopf WNT signaling pathway inhibitor 3
decreases expression
ISO
casticin results in decreased expression of DKK3 mRNA
CTD
PMID:27862857
NCBI chr 1:166,237,969...166,281,271
Ensembl chr 1:166,238,238...166,280,590
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Dnmt1
DNA methyltransferase 1
multiple interactions decreases activity decreases expression
ISO
casticin affects the reaction [MIR148A mRNA affects the activity of DNMT1 protein]; casticin affects the reaction [MIR148A mRNA affects the expression of DNMT1 mRNA]; casticin promotes the reaction [MIR148A mRNA results in decreased activity of DNMT1 protein]; casticin results in decreased expression of and results in decreased activity of DNMT1 protein; DNMT1 protein inhibits the reaction [casticin results in decreased activity of DNMT1 protein]; DNMT1 protein inhibits the reaction [casticin results in decreased expression of BMI1 protein]; DNMT1 protein inhibits the reaction [casticin results in decreased expression of CD44 protein]; DNMT1 protein inhibits the reaction [casticin results in decreased expression of EPCAM protein]; DNMT1 protein inhibits the reaction [casticin results in decreased expression of NANOG protein]; DNMT1 protein inhibits the reaction [casticin results in decreased expression of POU5F1 protein]; DNMT1 protein inhibits the reaction [casticin results in increased expression of MIR148A mRNA]; MIR148A mRNA affects the reaction [casticin results in decreased activity of DNMT1 protein]; MIR148A mRNA affects the reaction [casticin results in decreased expression of DNMT1 mRNA]; MIR148A mRNA promotes the reaction [casticin results in decreased activity of DNMT1 protein]
CTD
PMID:32268151
NCBI chr 8:19,440,611...19,486,659
Ensembl chr 8:19,440,611...19,486,659
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Dusp6
dual specificity phosphatase 6
decreases expression
ISO
casticin results in decreased expression of DUSP6 mRNA
CTD
PMID:28444820
NCBI chr 7:34,092,848...34,097,186
Ensembl chr 7:34,092,943...34,097,185
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Dyrk1a
dual specificity tyrosine phosphorylation regulated kinase 1A
decreases expression
ISO
casticin results in decreased expression of DYRK1A mRNA
CTD
PMID:28444820
NCBI chr11:33,890,706...34,009,420
Ensembl chr11:33,890,490...34,009,420
G
Egfr
epidermal growth factor receptor
decreases expression
ISO
casticin results in decreased expression of EGFR protein
CTD
PMID:28444820
NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382
G
Eif2s2
eukaryotic translation initiation factor 2 subunit beta
decreases expression
ISO
casticin results in decreased expression of EIF2S2 mRNA
CTD
PMID:28444820
NCBI chr 3:143,374,652...143,395,460
Ensembl chr 3:143,373,686...143,395,432
G
Eif5
eukaryotic translation initiation factor 5
decreases expression
ISO
casticin results in decreased expression of EIF5 mRNA
CTD
PMID:28444820
NCBI chr 6:130,589,162...130,597,656
Ensembl chr 6:130,589,143...130,597,656
G
Enc1
ectodermal-neural cortex 1
increases expression
ISO
casticin results in increased expression of ENC1 mRNA
CTD
PMID:27862857
NCBI chr 2:28,550,670...28,562,591
Ensembl chr 2:28,550,464...28,562,713
G
Endog
endonuclease G
decreases expression increases expression multiple interactions
ISO
casticin results in decreased expression of ENDOG protein casticin results in increased expression of ENDOG protein casticin inhibits the reaction [Fluorouracil results in increased expression of ENDOG protein]
CTD
PMID:29098808 PMID:32270916
NCBI chr 3:13,449,113...13,451,715
Ensembl chr 3:13,449,086...13,451,932
G
Ep300
E1A binding protein p300
decreases expression
ISO
casticin results in decreased expression of EP300 mRNA
CTD
PMID:27862857
NCBI chr 7:113,108,476...113,178,529
Ensembl chr 7:113,106,247...113,136,088 Ensembl chr 7:113,106,247...113,136,088
G
Epb41l4b
erythrocyte membrane protein band 4.1 like 4B
decreases expression
ISO
casticin results in decreased expression of EPB41L4B mRNA
CTD
PMID:28444820
NCBI chr 5:71,691,706...71,852,583
Ensembl chr 5:71,694,331...71,851,990
G
Epcam
epithelial cell adhesion molecule
multiple interactions decreases expression
ISO
casticin promotes the reaction [MIR148A mRNA results in decreased expression of EPCAM mRNA]; DNMT1 protein inhibits the reaction [casticin results in decreased expression of EPCAM protein]; MIR148A mRNA promotes the reaction [casticin results in decreased expression of EPCAM mRNA]
CTD
PMID:32268151
NCBI chr 6:6,880,142...6,896,103
Ensembl chr 6:6,878,237...6,896,127
G
Erbb3
erb-b2 receptor tyrosine kinase 3
increases expression
ISO
casticin results in increased expression of ERBB3 mRNA
CTD
PMID:27862857
NCBI chr 7:994,549...1,015,876
Ensembl chr 7:996,225...1,015,525
G
Esf1
ESF1 nucleolar pre-rRNA processing protein homolog
decreases expression
ISO
casticin results in decreased expression of ESF1 mRNA
CTD
PMID:28444820
NCBI chr 3:127,454,744...127,507,941
Ensembl chr 3:127,454,811...127,507,817
G
Exosc3
exosome component 3
decreases expression
ISO
casticin results in decreased expression of EXOSC3 mRNA
CTD
PMID:28444820
NCBI chr 5:59,573,849...59,579,065
Ensembl chr 5:59,573,886...59,579,060
G
Ext1
exostosin glycosyltransferase 1
increases expression
ISO
casticin results in increased expression of EXT1 mRNA
CTD
PMID:28444820
NCBI chr 7:84,375,769...84,654,625
Ensembl chr 7:84,375,784...84,655,357
G
Fadd
Fas associated via death domain
increases expression
ISO
casticin results in increased expression of FADD protein
CTD
PMID:27862857 PMID:29098808
NCBI chr 1:199,743,200...199,745,746
Ensembl chr 1:199,739,994...199,745,653
G
Fam227a
family with sequence similarity 227, member A
increases expression
ISO
casticin results in increased expression of FAM227A mRNA
CTD
PMID:28444820
NCBI chr 7:111,174,362...111,216,513
Ensembl chr 7:111,174,362...111,216,483
G
Fas
Fas cell surface death receptor
increases expression
ISO
casticin results in increased expression of FAS protein
CTD
PMID:27862857 PMID:29098808
NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
G
Faslg
Fas ligand
increases expression decreases expression
ISO
casticin results in increased expression of FASLG protein casticin results in decreased expression of FASLG protein
CTD
PMID:27862857 PMID:29098808
NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215
G
Fbxo11
F-box protein 11
decreases expression
ISO
casticin results in decreased expression of FBXO11 mRNA
CTD
PMID:28444820
NCBI chr 6:6,486,761...6,562,664
Ensembl chr 6:6,486,015...6,562,662
G
Fbxo44
F-box protein 44
decreases expression
ISO
casticin results in decreased expression of FBXO44 mRNA
CTD
PMID:28444820
NCBI chr 5:158,583,363...158,592,510
Ensembl chr 5:158,583,366...158,592,363
G
Fez1
fasciculation and elongation protein zeta 1
decreases expression
ISO
casticin results in decreased expression of FEZ1 mRNA
CTD
PMID:28444820
NCBI chr 8:36,544,462...36,589,684
Ensembl chr 8:36,544,535...36,589,683
G
Foxo3
forkhead box O3
decreases expression
ISO
casticin results in decreased expression of FOXO3 mRNA
CTD
PMID:27862857
NCBI chr20:45,669,708...45,764,606
Ensembl chr20:45,672,995...45,764,561
G
Foxp2
forkhead box P2
decreases expression
ISO
casticin results in decreased expression of FOXP2 mRNA
CTD
PMID:28444820
NCBI chr 4:43,133,827...43,712,442
Ensembl chr 4:43,133,912...43,711,683
G
Gadd45a
growth arrest and DNA-damage-inducible, alpha
decreases expression
ISO
casticin results in decreased expression of GADD45A mRNA
CTD
PMID:28444820
NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115
G
Glud1
glutamate dehydrogenase 1
decreases expression
ISO
casticin results in decreased expression of GLUD1 mRNA
CTD
PMID:28444820
NCBI chr16:9,640,312...9,673,961
Ensembl chr16:9,640,312...9,673,957
G
Gphn
gephyrin
decreases expression
ISO
casticin results in decreased expression of GPHN mRNA
CTD
PMID:28444820
NCBI chr 6:96,954,365...97,483,617
Ensembl chr 6:96,892,148...97,483,612
G
Gpr85
G protein-coupled receptor 85
decreases expression
ISO
casticin results in decreased expression of GPR85 mRNA
CTD
PMID:28444820
NCBI chr 4:42,100,138...42,109,584
Ensembl chr 4:42,102,941...42,109,566
G
Grb2
growth factor receptor bound protein 2
decreases expression
ISO
casticin results in decreased expression of GRB2 protein
CTD
PMID:28444820
NCBI chr10:100,881,404...100,949,193
Ensembl chr10:100,869,718...100,949,309
G
Grid2
glutamate ionotropic receptor delta type subunit 2
decreases expression
ISO
casticin results in decreased expression of GRID2 mRNA
CTD
PMID:27862857
NCBI chr 4:92,415,019...93,892,472
Ensembl chr 4:92,415,230...93,889,355
G
Gtf2h2
general transcription factor IIH subunit 2
decreases expression
ISO
casticin results in decreased expression of GTF2H2 mRNA
CTD
PMID:28444820
NCBI chr 2:31,623,752...31,652,697
Ensembl chr 2:31,624,678...31,652,592
G
Hcn2
hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2
decreases expression
ISO
casticin results in decreased expression of HCN2 mRNA
CTD
PMID:27862857
NCBI chr 7:9,969,801...9,988,839
Ensembl chr 7:9,970,368...9,988,841
G
Hoxb8
homeo box B8
decreases expression
ISO
casticin results in decreased expression of HOXB8 mRNA
CTD
PMID:28444820
NCBI chr10:81,248,313...81,251,261
Ensembl chr10:81,248,887...81,250,638
G
Hoxb9
homeo box B9
decreases expression
ISO
casticin results in decreased expression of HOXB9 mRNA
CTD
PMID:27862857
NCBI chr10:81,237,312...81,240,818
Ensembl chr10:81,237,312...81,240,818
G
Hspa4
heat shock protein family A (Hsp70) member 4
decreases expression
ISO
casticin results in decreased expression of HSPA4 mRNA
CTD
PMID:28444820
NCBI chr10:37,408,025...37,449,080
Ensembl chr10:37,408,025...37,449,001
G
Hspa5
heat shock protein family A (Hsp70) member 5
increases expression
ISO
casticin results in increased expression of HSPA5 protein
CTD
PMID:27862857
NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
G
Hspa8
heat shock protein family A (Hsp70) member 8
increases expression
ISO
casticin results in increased expression of HSPA8 mRNA
CTD
PMID:28444820
NCBI chr 8:41,183,397...41,187,260
Ensembl chr 8:41,183,264...41,187,259
G
Hspa9
heat shock protein family A (Hsp70) member 9
decreases expression
ISO
casticin results in decreased expression of HSPA9 mRNA
CTD
PMID:28444820
NCBI chr18:26,536,131...26,554,294
Ensembl chr18:26,535,798...26,554,292
G
Il12a
interleukin 12A
decreases expression
ISO
casticin results in decreased expression of IL12A mRNA
CTD
PMID:27862857
NCBI chr 2:152,965,769...152,973,035
Ensembl chr 2:152,965,769...152,972,734
G
Il6
interleukin 6
decreases expression
ISO
casticin results in decreased expression of IL6 mRNA
CTD
PMID:27862857
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
G
Ints6
integrator complex subunit 6
decreases expression
ISO
casticin results in decreased expression of INTS6 mRNA
CTD
PMID:28444820
NCBI chr15:36,908,966...37,048,043
Ensembl chr15:36,933,724...37,021,527
G
Irak4
interleukin-1 receptor-associated kinase 4
increases expression
ISO
casticin results in increased expression of IRAK4 mRNA
CTD
PMID:27862857
NCBI chr 7:125,682,502...125,708,294
Ensembl chr 7:125,682,488...125,717,837
G
Irf2bp2
interferon regulatory factor 2 binding protein 2
decreases expression
ISO
casticin results in decreased expression of IRF2BP2 mRNA
CTD
PMID:28444820
NCBI chr19:54,559,417...54,565,096
Ensembl chr19:54,560,128...54,566,642
G
Kcnh2
potassium voltage-gated channel subfamily H member 2
decreases expression
ISO
casticin results in decreased expression of KCNH2 mRNA
CTD
PMID:28444820
NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
G
Kctd9
potassium channel tetramerization domain containing 9
decreases expression
ISO
casticin results in decreased expression of KCTD9 mRNA
CTD
PMID:28444820
NCBI chr15:41,942,165...41,969,862
Ensembl chr15:41,942,381...41,969,862
G
Kirrel3
kirre like nephrin family adhesion molecule 3
decreases expression
ISO
casticin results in decreased expression of KIRREL3 mRNA
CTD
PMID:28444820
NCBI chr 8:32,865,779...33,407,555
Ensembl chr 8:32,862,776...33,405,676
G
Klf9
KLF transcription factor 9
decreases expression
ISO
casticin results in decreased expression of KLF9 mRNA
CTD
PMID:28444820
NCBI chr 1:220,700,108...220,725,110
Ensembl chr 1:220,700,108...220,725,037
G
Krt16
keratin 16
increases expression
ISO
casticin results in increased expression of KRT16 mRNA
CTD
PMID:28444820
NCBI chr10:85,168,357...85,171,816
Ensembl chr10:85,066,802...85,171,799
G
Ldhb
lactate dehydrogenase B
decreases expression
ISO
casticin results in decreased expression of LDHB mRNA
CTD
PMID:27862857
NCBI chr 4:175,428,382...175,446,403
Ensembl chr 4:175,428,385...175,446,403
G
Lef1
lymphoid enhancer binding factor 1
decreases expression
ISO
casticin results in decreased expression of LEF1 mRNA
CTD
PMID:27862857
NCBI chr 2:219,666,549...219,779,815
Ensembl chr 2:219,666,592...219,779,794
G
Lhfpl6
LHFPL tetraspan subfamily member 6
increases expression
ISO
casticin results in increased expression of LHFPL6 mRNA
CTD
PMID:28444820
NCBI chr 2:137,126,485...137,324,442
Ensembl chr 2:137,126,509...137,324,443
G
Limch1
LIM and calponin homology domains 1
increases expression
ISO
casticin results in increased expression of LIMCH1 mRNA
CTD
PMID:28444820
NCBI chr14:41,112,579...41,425,001
Ensembl chr14:41,114,803...41,425,191
G
Lpl
lipoprotein lipase
decreases expression
ISO
casticin results in decreased expression of LPL mRNA
CTD
PMID:27862857
NCBI chr16:20,830,055...20,853,855
Ensembl chr16:20,829,465...20,855,249
G
Lrp5
LDL receptor related protein 5
increases expression
ISO
casticin results in increased expression of LRP5 mRNA
CTD
PMID:27862857
NCBI chr 1:200,814,247...200,917,581
Ensembl chr 1:200,814,250...200,917,581
G
Ltv1
LTV1 ribosome biogenesis factor
decreases expression
ISO
casticin results in decreased expression of LTV1 mRNA
CTD
PMID:28444820
NCBI chr 1:7,565,673...7,578,398
Ensembl chr 1:7,565,669...7,578,563
G
Maf
MAF bZIP transcription factor
decreases expression
ISO
casticin results in decreased expression of MAF mRNA
CTD
PMID:28444820
NCBI chr19:43,353,867...43,713,162
Ensembl chr19:43,360,342...43,712,365
G
Magoh
mago homolog, exon junction complex subunit
decreases expression
ISO
casticin results in decreased expression of MAGOH mRNA
CTD
PMID:28444820
NCBI chr 5:122,639,268...122,646,650
Ensembl chr 5:122,639,308...122,646,617
G
Map3k7
mitogen activated protein kinase kinase kinase 7
increases expression
ISO
casticin results in increased expression of MAP3K7 mRNA
CTD
PMID:27862857
NCBI chr 5:46,356,973...46,415,597
Ensembl chr 5:46,357,931...46,415,597
G
Mapre2
microtubule-associated protein, RP/EB family, member 2
increases expression
ISO
casticin results in increased expression of MAPRE2 mRNA
CTD
PMID:28444820
NCBI chr18:15,028,675...15,169,553
Ensembl chr18:15,029,041...15,168,044
G
Mark3
microtubule affinity regulating kinase 3
decreases expression
ISO
casticin results in decreased expression of MARK3 mRNA
CTD
PMID:28444820
NCBI chr 6:130,626,612...130,716,245
Ensembl chr 6:130,627,482...130,716,647
G
Max
MYC associated factor X
decreases expression
ISO
casticin results in decreased expression of MAX mRNA
CTD
PMID:28444820
NCBI chr 6:95,636,859...95,662,204
Ensembl chr 6:95,636,858...95,662,137
G
Mbp
myelin basic protein
increases expression
ISO
casticin results in increased expression of MBP mRNA
CTD
PMID:28444820
NCBI chr18:75,855,878...75,966,404
Ensembl chr18:75,855,878...75,966,404
G
Mcl1
MCL1 apoptosis regulator, BCL2 family member
decreases expression
ISO
casticin results in decreased expression of MCL1 protein
CTD
PMID:27862857
NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303
G
Mdc1
mediator of DNA damage checkpoint 1
increases expression
ISO
casticin results in increased expression of MDC1 protein
CTD
PMID:29098808
NCBI chr20:2,893,693...2,912,394
Ensembl chr20:2,895,505...2,910,240
G
Mecom
MDS1 and EVI1 complex locus
decreases expression
ISO
casticin results in decreased expression of MECOM mRNA
CTD
PMID:28444820
NCBI chr 2:112,909,353...113,464,583
Ensembl chr 2:112,909,321...113,464,590
G
Mest
mesoderm specific transcript
increases expression
ISO
casticin results in increased expression of MEST mRNA
CTD
PMID:28444820
NCBI chr 4:59,354,445...59,364,919
Ensembl chr 4:59,354,447...59,366,145
G
Mettl3
methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit
decreases expression
ISO
casticin results in decreased expression of METTL3 mRNA
CTD
PMID:28444820
NCBI chr15:25,002,505...25,014,097
Ensembl chr15:25,003,172...25,014,041
G
Mir148a
microRNA 148a
increases expression multiple interactions
ISO
casticin results in increased expression of MIR148A mRNA casticin affects the reaction [MIR148A mRNA affects the activity of DNMT1 protein]; casticin affects the reaction [MIR148A mRNA affects the expression of CD44 mRNA]; casticin affects the reaction [MIR148A mRNA affects the expression of DNMT1 mRNA]; casticin affects the reaction [MIR148A mRNA results in increased expression of MIR148A mRNA]; casticin promotes the reaction [MIR148A mRNA results in decreased activity of DNMT1 protein]; casticin promotes the reaction [MIR148A mRNA results in decreased expression of BMI1 mRNA]; casticin promotes the reaction [MIR148A mRNA results in decreased expression of CD44 protein]; casticin promotes the reaction [MIR148A mRNA results in decreased expression of EPCAM mRNA]; casticin promotes the reaction [MIR148A mRNA results in decreased expression of NANOG mRNA]; casticin promotes the reaction [MIR148A mRNA results in decreased expression of POU5F1 mRNA]; DNMT1 protein inhibits the reaction [casticin results in increased expression of MIR148A mRNA]; MIR148A mRNA affects the reaction [casticin results in decreased activity of DNMT1 protein]; MIR148A mRNA affects the reaction [casticin results in decreased expression of DNMT1 mRNA]; MIR148A mRNA affects the reaction [casticin results in increased expression of MIR148A mRNA]; MIR148A mRNA promotes the reaction [casticin results in decreased activity of DNMT1 protein]; MIR148A mRNA promotes the reaction [casticin results in decreased expression of BMI1 mRNA]; MIR148A mRNA promotes the reaction [casticin results in decreased expression of CD44 protein]; MIR148A mRNA promotes the reaction [casticin results in decreased expression of EPCAM mRNA]; MIR148A mRNA promotes the reaction [casticin results in decreased expression of NANOG mRNA]; MIR148A mRNA promotes the reaction [casticin results in decreased expression of POU5F1 mRNA]
CTD
PMID:32268151
NCBI chr 4:80,333,762...80,333,858
Ensembl chr 4:80,333,762...80,333,858
G
Mmp2
matrix metallopeptidase 2
decreases expression
ISO
casticin results in decreased expression of MMP2 mRNA casticin results in decreased expression of MMP2 protein
CTD
PMID:27862857 PMID:28444820
NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
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Mmp9
matrix metallopeptidase 9
decreases expression
ISO
casticin results in decreased expression of MMP9 protein
CTD
PMID:28444820
NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
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Mplkip
M-phase specific PLK1 interacting protein
decreases expression
ISO
casticin results in decreased expression of MPLKIP mRNA
CTD
PMID:28444820
NCBI chr17:47,373,624...47,376,199
Ensembl chr17:47,373,845...47,376,204
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mrpl9
mitochondrial ribosomal protein L9
increases expression
ISO
casticin results in increased expression of MRPL9 mRNA
CTD
PMID:28444820
NCBI chr 2:182,082,012...182,086,758
Ensembl chr 2:182,076,369...182,087,095
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Muc13
mucin 13, cell surface associated
increases expression
ISO
casticin results in increased expression of MUC13 mRNA
CTD
PMID:27862857
NCBI chr11:66,957,208...66,980,264
Ensembl chr11:66,960,595...66,984,727
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Myd88
MYD88, innate immune signal transduction adaptor
increases expression
ISO
casticin results in increased expression of MYD88 mRNA
CTD
PMID:27862857
NCBI chr 8:119,074,439...119,078,508
Ensembl chr 8:119,074,437...119,079,415
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Myo7a
myosin VIIA
increases expression
ISO
casticin results in increased expression of MYO7A mRNA
CTD
PMID:28444820
NCBI chr 1:152,342,611...152,414,171
Ensembl chr 1:152,344,448...152,414,157
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Nanog
Nanog homeobox
multiple interactions decreases expression
ISO
casticin promotes the reaction [MIR148A mRNA results in decreased expression of NANOG mRNA]; DNMT1 protein inhibits the reaction [casticin results in decreased expression of NANOG protein]; MIR148A mRNA promotes the reaction [casticin results in decreased expression of NANOG mRNA]
CTD
PMID:32268151
NCBI chr 4:155,943,737...155,951,116
Ensembl chr 4:155,943,737...155,951,116
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Nars1
asparaginyl-tRNA synthetase 1
decreases expression
ISO
casticin results in decreased expression of NARS1 mRNA
CTD
PMID:28444820
NCBI chr18:57,989,308...58,005,584
Ensembl chr18:57,989,308...58,005,622
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Ndufs4
NADH:ubiquinone oxidoreductase subunit S4
decreases expression
ISO
casticin results in decreased expression of NDUFS4 mRNA
CTD
PMID:28444820
NCBI chr 2:45,951,327...46,061,829
Ensembl chr 2:45,951,313...46,061,846
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Nfkb1
nuclear factor kappa B subunit 1
decreases expression
ISO
casticin results in decreased expression of NFKB1 mRNA
CTD
PMID:27862857
NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
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Nfkb2
nuclear factor kappa B subunit 2
decreases expression
ISO
casticin results in decreased expression of NFKB2 mRNA
CTD
PMID:27862857
NCBI chr 1:245,164,586...245,173,225
Ensembl chr 1:245,165,950...245,173,213
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Nfkbia
NFKB inhibitor alpha
decreases expression
ISO
casticin results in decreased expression of NFKBIA mRNA
CTD
PMID:27862857
NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
G
Nfkbib
NFKB inhibitor beta
decreases expression
ISO
casticin results in decreased expression of NFKBIB mRNA
CTD
PMID:27862857
NCBI chr 1:84,046,292...84,053,862
Ensembl chr 1:84,046,295...84,053,862
G
Nfkbid
NFKB inhibitor delta
decreases expression
ISO
casticin results in decreased expression of NFKBID mRNA
CTD
PMID:27862857
NCBI chr 1:85,679,353...85,690,415
Ensembl chr 1:85,680,861...85,690,447
G
Nfkbie
NFKB inhibitor epsilon
decreases expression
ISO
casticin results in decreased expression of NFKBIE mRNA
CTD
PMID:27862857
NCBI chr 9:15,443,600...15,450,437
Ensembl chr 9:15,436,941...15,450,437
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Nfx1
nuclear transcription factor, X-box binding 1
increases expression
ISO
casticin results in increased expression of NFX1 mRNA
CTD
PMID:28444820
NCBI chr 5:56,104,945...56,162,912
Ensembl chr 5:56,105,234...56,162,912
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Nkd1
NKD inhibitor of WNT signaling pathway 1
increases expression
ISO
casticin results in increased expression of NKD1 mRNA
CTD
PMID:27862857
NCBI chr19:18,476,344...18,549,380
Ensembl chr19:18,476,344...18,549,380
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Nme9
NME/NM23 family member 9
increases expression
ISO
casticin results in increased expression of NME9 mRNA
CTD
PMID:28444820
NCBI chr 8:100,013,190...100,034,511
G
Nmt1
N-myristoyltransferase 1
decreases expression
ISO
casticin results in decreased expression of NMT1 mRNA
CTD
PMID:28444820
NCBI chr10:87,988,826...88,025,405
Ensembl chr10:87,988,826...88,022,648
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Nol4l
nucleolar protein 4-like
decreases expression
ISO
casticin results in decreased expression of NOL4L mRNA
CTD
PMID:28444820
NCBI chr 3:141,884,840...142,007,668
Ensembl chr 3:141,884,840...142,008,976
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Nop58
NOP58 ribonucleoprotein
decreases expression
ISO
casticin results in decreased expression of NOP58 mRNA
CTD
PMID:28444820
NCBI chr 9:61,120,939...61,144,810
Ensembl chr 9:61,120,929...61,144,810
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Npas3
neuronal PAS domain protein 3
decreases expression
ISO
casticin results in decreased expression of NPAS3 mRNA
CTD
PMID:28444820
NCBI chr 6:70,702,773...71,527,928
Ensembl chr 6:70,703,170...71,524,884
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Nrg3
neuregulin 3
decreases expression
ISO
casticin results in decreased expression of NRG3 mRNA
CTD
PMID:27862857
NCBI chr16:14,229,270...15,352,505
Ensembl chr16:14,235,157...15,352,368
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Nup205
nucleoporin 205
decreases expression
ISO
casticin results in decreased expression of NUP205 mRNA
CTD
PMID:28444820
NCBI chr 4:63,854,934...63,920,852
Ensembl chr 4:63,854,783...63,920,844
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Nup37
nucleoporin 37
decreases expression
ISO
casticin results in decreased expression of NUP37 mRNA
CTD
PMID:28444820
NCBI chr 7:22,556,544...22,609,622
Ensembl chr 7:22,573,764...22,609,616
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Olig2
oligodendrocyte transcription factor 2
decreases expression
ISO
casticin results in decreased expression of OLIG2 mRNA
CTD
PMID:27862857
NCBI chr11:30,475,510...30,478,886
Ensembl chr11:30,475,398...30,480,152
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Orc5
origin recognition complex, subunit 5
decreases expression
ISO
casticin results in decreased expression of ORC5 mRNA
CTD
PMID:28444820
NCBI chr 4:12,548,007...12,612,611
Ensembl chr 4:12,548,007...12,612,568
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Otub2
OTU deubiquitinase, ubiquitin aldehyde binding 2
decreases expression
ISO
casticin results in decreased expression of OTUB2 mRNA
CTD
PMID:28444820
NCBI chr 6:122,545,067...122,563,657
Ensembl chr 6:122,545,061...122,563,644
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P2rx7
purinergic receptor P2X 7
increases expression
ISO
casticin results in increased expression of P2RX7 mRNA
CTD
PMID:28444820
NCBI chr12:33,889,709...33,934,168
Ensembl chr12:33,879,745...33,934,619
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Paip1
poly(A) binding protein interacting protein 1
decreases expression
ISO
casticin results in decreased expression of PAIP1 mRNA
CTD
PMID:28444820
NCBI chr 2:51,523,190...51,550,241
Ensembl chr 2:51,522,921...51,550,241
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Pak3
p21 (RAC1) activated kinase 3
decreases expression
ISO
casticin results in decreased expression of PAK3 mRNA
CTD
PMID:27862857
NCBI chr X:107,116,308...107,374,342
Ensembl chr X:107,260,898...107,368,314
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Papola
poly (A) polymerase alpha
decreases expression
ISO
casticin results in decreased expression of PAPOLA mRNA
CTD
PMID:28444820
NCBI chr 6:124,682,015...124,734,706
Ensembl chr 6:124,682,105...124,734,468
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Parp1
poly (ADP-ribose) polymerase 1
increases expression
ISO
casticin results in increased expression of PARP1 protein
CTD
PMID:32270916
NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
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Pcdha1
protocadherin alpha 1
increases expression
ISO
casticin results in increased expression of PCDHA1 mRNA
CTD
PMID:28444820
Ensembl chr18:28,581,225...28,846,211
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Phf10
PHD finger protein 10
decreases expression
ISO
casticin results in decreased expression of PHF10 mRNA
CTD
PMID:28444820
NCBI chr 1:55,952,249...55,968,994
Ensembl chr 1:55,952,253...55,969,038
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Picalm
phosphatidylinositol binding clathrin assembly protein
decreases expression
ISO
casticin results in decreased expression of PICALM mRNA
CTD
PMID:28444820
NCBI chr 1:144,056,415...144,138,045
Ensembl chr 1:144,056,721...144,137,557
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Plau
plasminogen activator, urokinase
decreases expression
ISO
casticin results in decreased expression of PLAU protein
CTD
PMID:28444820
NCBI chr15:3,456,230...3,462,732
Ensembl chr15:3,456,232...3,462,775
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Pmp22
peripheral myelin protein 22
increases expression
ISO
casticin results in increased expression of PMP22 mRNA
CTD
PMID:28444820
NCBI chr10:47,795,709...47,825,715
Ensembl chr10:47,795,709...47,825,714
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Pou5f1
POU class 5 homeobox 1
multiple interactions decreases expression
ISO
casticin promotes the reaction [MIR148A mRNA results in decreased expression of POU5F1 mRNA]; DNMT1 protein inhibits the reaction [casticin results in decreased expression of POU5F1 protein]; MIR148A mRNA promotes the reaction [casticin results in decreased expression of POU5F1 mRNA]
CTD
PMID:32268151
NCBI chr20:3,223,128...3,227,891
Ensembl chr20:3,223,129...3,227,891
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Ppard
peroxisome proliferator-activated receptor delta
decreases expression
ISO
casticin results in decreased expression of PPARD mRNA
CTD
PMID:27862857
NCBI chr20:6,298,785...6,363,970
Ensembl chr20:6,298,785...6,363,968
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Pparg
peroxisome proliferator-activated receptor gamma
increases expression
ISO
casticin results in increased expression of PPARG mRNA
CTD
PMID:27862857
NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
G
Ppargc1a
PPARG coactivator 1 alpha
decreases expression
ISO
casticin results in decreased expression of PPARGC1A mRNA
CTD
PMID:28444820
NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656
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Ppp1r11
protein phosphatase 1, regulatory (inhibitor) subunit 11
decreases expression
ISO
casticin results in decreased expression of PPP1R11 mRNA
CTD
PMID:28444820
NCBI chr20:1,601,350...1,604,857
Ensembl chr20:1,601,346...1,604,846
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Ppp6r3
protein phosphatase 6, regulatory subunit 3
decreases expression
ISO
casticin results in decreased expression of PPP6R3 mRNA
CTD
PMID:28444820
NCBI chr 1:200,693,128...200,807,578
Ensembl chr 1:200,693,440...200,807,548
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Prkar2b
protein kinase cAMP-dependent type II regulatory subunit beta
decreases expression
ISO
casticin results in decreased expression of PRKAR2B mRNA
CTD
PMID:27862857
NCBI chr 6:48,563,659...48,653,933
Ensembl chr 6:48,563,662...48,653,933
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Prkdc
protein kinase, DNA-activated, catalytic subunit
decreases expression
ISO
casticin results in decreased expression of PRKDC protein
CTD
PMID:29098808
NCBI chr11:85,040,790...85,258,357
Ensembl chr11:85,040,792...85,257,952
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Prss44
serine protease 44
increases expression
ISO
casticin results in increased expression of PRSS44 mRNA
CTD
PMID:28444820
NCBI chr 8:110,791,698...110,805,303
Ensembl chr 8:110,791,698...110,805,303
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Ptk2
protein tyrosine kinase 2
decreases expression
ISO
casticin results in decreased expression of PTK2 protein
CTD
PMID:28444820
NCBI chr 7:105,126,725...105,331,848
Ensembl chr 7:105,126,728...105,331,783
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Ptpra
protein tyrosine phosphatase, receptor type, A
increases expression
ISO
casticin results in increased expression of PTPRA mRNA
CTD
PMID:28444820
NCBI chr 3:117,650,146...117,759,744
Ensembl chr 3:117,650,183...117,759,728
G
Ptprd
protein tyrosine phosphatase, receptor type, D
decreases expression
ISO
casticin results in decreased expression of PTPRD mRNA
CTD
PMID:28444820
NCBI chr 5:90,046,993...90,698,977 NCBI chr 5:91,122,354...91,641,754
Ensembl chr 5:90,048,966...92,369,396
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Ptprf
protein tyrosine phosphatase, receptor type, F
decreases expression
ISO
casticin results in decreased expression of PTPRF mRNA
CTD
PMID:28444820
NCBI chr 5:131,741,959...131,824,000
Ensembl chr 5:131,742,754...131,810,023
G
Qki
QKI, KH domain containing RNA binding
decreases expression
ISO
casticin results in decreased expression of QKI mRNA
CTD
PMID:28444820
NCBI chr 1:50,387,716...50,501,568
Ensembl chr 1:50,387,698...50,498,831
G
Rapgef4
Rap guanine nucleotide exchange factor 4
decreases expression
ISO
casticin results in decreased expression of RAPGEF4 mRNA
CTD
PMID:28444820
NCBI chr 3:56,809,388...57,101,332
Ensembl chr 3:56,809,270...57,102,316
G
Rars1
arginyl-tRNA synthetase 1
decreases expression
ISO
casticin results in decreased expression of RARS1 mRNA
CTD
PMID:28444820
NCBI chr10:20,270,744...20,295,192
Ensembl chr10:20,270,483...20,295,196
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Rbmx2
RNA binding motif protein, X-linked 2
decreases expression
ISO
casticin results in decreased expression of RBMX2 mRNA
CTD
PMID:28444820
NCBI chr X:127,888,514...127,896,239
Ensembl chr X:127,888,438...127,896,869
G
Rcor3
REST corepressor 3
decreases expression
ISO
casticin results in decreased expression of RCOR3 mRNA
CTD
PMID:28444820
NCBI chr13:103,624,966...103,665,565
Ensembl chr13:103,624,971...103,665,565
G
Rela
RELA proto-oncogene, NF-kB subunit
decreases expression
ISO
casticin results in decreased expression of RELA protein
CTD
PMID:28444820
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
G
Rexo2
RNA exonuclease 2
decreases expression
ISO
casticin results in decreased expression of REXO2 mRNA
CTD
PMID:28444820
NCBI chr 8:48,811,900...48,823,622
Ensembl chr 8:48,811,900...48,823,622
G
Rhoa
ras homolog family member A
decreases expression
ISO
casticin results in decreased expression of RHOA protein
CTD
PMID:28444820
NCBI chr 8:108,991,926...109,025,746
Ensembl chr 8:108,991,954...109,025,746
G
Rpl22l1
ribosomal protein L22 like 1
decreases expression
ISO
casticin results in decreased expression of RPL22L1 mRNA
CTD
PMID:28444820
NCBI chr 2:111,754,687...111,756,623
Ensembl chr 2:111,754,687...111,756,625
G
S100a13
S100 calcium binding protein A13
increases expression
ISO
casticin results in increased expression of S100A13 mRNA
CTD
PMID:28444820
NCBI chr 2:175,999,439...176,005,933
G
Scn1b
sodium voltage-gated channel beta subunit 1
increases expression
ISO
casticin results in increased expression of SCN1B mRNA
CTD
PMID:28444820
NCBI chr 1:86,353,917...86,363,820
Ensembl chr 1:86,353,917...86,363,739
G
Slc31a1
solute carrier family 31 member 1
increases expression
ISO
casticin results in increased expression of SLC31A1 mRNA
CTD
PMID:28444820
NCBI chr 5:75,814,744...75,844,241
Ensembl chr 5:75,814,743...75,844,228
G
Slc6a9
solute carrier family 6 member 9
decreases expression
ISO
casticin results in decreased expression of SLC6A9 mRNA
CTD
PMID:28444820
NCBI chr 5:131,374,562...131,408,733
Ensembl chr 5:131,374,542...131,408,728
G
Smad1
SMAD family member 1
increases expression
ISO
casticin results in increased expression of SMAD1 mRNA
CTD
PMID:27862857
NCBI chr19:28,513,130...28,573,665
Ensembl chr19:28,513,131...28,573,651
G
Smad3
SMAD family member 3
increases expression
ISO
casticin results in increased expression of SMAD3 mRNA
CTD
PMID:27862857
NCBI chr 8:64,126,829...64,236,960
Ensembl chr 8:64,110,039...64,236,960
G
Snrpg
small nuclear ribonucleoprotein polypeptide G
decreases expression
ISO
casticin results in decreased expression of SNRPG mRNA
CTD
PMID:28444820
NCBI chr 4:118,812,278...118,819,827
Ensembl chr 4:118,812,252...118,819,826
G
Snw1
SNW domain containing 1
decreases expression
ISO
casticin results in decreased expression of SNW1 mRNA
CTD
PMID:28444820
NCBI chr 6:107,095,450...107,119,536
Ensembl chr 6:107,095,457...107,119,536
G
Sod1
superoxide dismutase 1
multiple interactions increases expression
ISO
casticin promotes the reaction [Fluorouracil results in increased expression of SOD1 protein]; Fluorouracil promotes the reaction [casticin results in increased expression of SOD1 protein]
CTD
PMID:32270916
NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
G
Sos1
SOS Ras/Rac guanine nucleotide exchange factor 1
decreases expression
ISO
casticin results in decreased expression of SOS1 protein
CTD
PMID:28444820
NCBI chr 6:14,533,870...14,613,348
Ensembl chr 6:14,533,360...14,611,107
G
Sparc
secreted protein acidic and cysteine rich
decreases expression increases expression
ISO
casticin results in decreased expression of SPARC mRNA casticin results in increased expression of SPARC mRNA
CTD
PMID:27862857 PMID:28444820
NCBI chr10:39,516,394...39,538,252
Ensembl chr10:39,516,406...39,538,396
G
Sparcl1
SPARC like 1
increases expression
ISO
casticin results in increased expression of SPARCL1 mRNA
CTD
PMID:28444820
NCBI chr14:5,632,816...5,663,866
Ensembl chr14:5,632,569...5,663,865
G
St13
ST13, Hsp70 interacting protein
increases expression
ISO
casticin results in increased expression of ST13 mRNA
CTD
PMID:28444820
NCBI chr 7:112,891,007...112,925,727
Ensembl chr 7:112,844,375...112,925,945
G
St3gal3
ST3 beta-galactoside alpha-2,3-sialyltransferase 3
decreases expression
ISO
casticin results in decreased expression of ST3GAL3 mRNA
CTD
PMID:28444820
NCBI chr 5:131,470,348...131,670,794
Ensembl chr 5:131,470,348...131,670,810
G
Strbp
spermatid perinuclear RNA binding protein
decreases expression
ISO
casticin results in decreased expression of STRBP mRNA
CTD
PMID:28444820
NCBI chr 3:21,328,310...21,467,753
Ensembl chr 3:21,337,855...21,414,949
G
Sugp1
SURP and G patch domain containing 1
decreases expression
ISO
casticin results in decreased expression of SUGP1 mRNA
CTD
PMID:28444820
NCBI chr16:19,352,659...19,383,533
Ensembl chr16:19,351,793...19,383,756
G
Syncrip
synaptotagmin binding, cytoplasmic RNA interacting protein
decreases expression
ISO
casticin results in decreased expression of SYNCRIP mRNA
CTD
PMID:28444820
NCBI chr 8:89,402,487...89,435,517
Ensembl chr 8:89,402,866...89,435,515
G
Syt9
synaptotagmin 9
decreases expression
ISO
casticin results in decreased expression of SYT9 mRNA
CTD
PMID:28444820
NCBI chr 1:161,275,882...161,456,384
Ensembl chr 1:161,275,734...161,455,007
G
Tab2
TGF-beta activated kinase 1/MAP3K7 binding protein 2
decreases expression
ISO
casticin results in decreased expression of TAB2 mRNA
CTD
PMID:27862857
NCBI chr 1:2,375,026...2,425,115
Ensembl chr 1:2,375,490...2,424,756
G
Tcf7
transcription factor 7
decreases expression
ISO
casticin results in decreased expression of TCF7 mRNA
CTD
PMID:28444820
NCBI chr10:36,423,443...36,454,350
Ensembl chr10:36,423,445...36,453,535
G
Thra
thyroid hormone receptor alpha
decreases expression
ISO
casticin results in decreased expression of THRA mRNA
CTD
PMID:28444820
NCBI chr10:83,701,885...83,729,408
Ensembl chr10:83,700,755...83,729,936
G
Timp2
TIMP metallopeptidase inhibitor 2
increases expression
ISO
casticin results in increased expression of TIMP2 mRNA
CTD
PMID:28444820
NCBI chr10:103,541,199...103,590,611
Ensembl chr10:103,531,505...103,590,611
G
Tlk2
tousled-like kinase 2
decreases expression
ISO
casticin results in decreased expression of TLK2 mRNA
CTD
PMID:28444820
NCBI chr10:90,154,449...90,248,562
Ensembl chr10:90,156,813...90,248,561
G
Tlr4
toll-like receptor 4
decreases expression
ISO
casticin results in decreased expression of TLR4 mRNA
CTD
PMID:27862857
NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
G
Tmbim4
transmembrane BAX inhibitor motif containing 4
increases expression
ISO
casticin results in increased expression of TMBIM4 mRNA
CTD
PMID:27862857
NCBI chr 7:55,718,690...55,733,277
Ensembl chr 7:55,718,699...55,742,773
G
Tmem45b
transmembrane protein 45b
increases expression
ISO
casticin results in increased expression of TMEM45B mRNA
CTD
PMID:27862857
NCBI chr 8:29,865,276...29,910,453
Ensembl chr 8:29,865,278...29,910,453
G
Tmsb10
thymosin, beta 10
increases expression
ISO
casticin results in increased expression of TMSB10 mRNA
CTD
PMID:28444820
NCBI chr 4:105,009,959...105,011,095
Ensembl chr 4:105,009,212...105,011,028
G
Tnfsf10
TNF superfamily member 10
increases expression
ISO
casticin results in increased expression of TNFSF10 protein
CTD
PMID:27862857
NCBI chr 2:110,199,835...110,227,239
Ensembl chr 2:110,207,916...110,225,135
G
Tnpo1
transportin 1
decreases expression
ISO
casticin results in decreased expression of TNPO1 mRNA
CTD
PMID:28444820
NCBI chr 2:30,207,529...30,300,162
Ensembl chr 2:30,211,510...30,300,375
G
Tor1aip2
torsin 1A interacting protein 2
decreases expression
ISO
casticin results in decreased expression of TOR1AIP2 mRNA
CTD
PMID:28444820
NCBI chr13:68,225,226...68,256,536
Ensembl chr13:68,230,009...68,256,536 Ensembl chr13:68,230,009...68,256,536
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Tp53
tumor protein p53
increases expression decreases expression
ISO
casticin results in increased expression of TP53 protein modified form casticin results in decreased expression of TP53 protein
CTD
PMID:29098808
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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Tpi1
triosephosphate isomerase 1
increases expression
ISO
casticin results in increased expression of TPI1 mRNA
CTD
PMID:28444820
NCBI chr 4:157,615,283...157,618,813
Ensembl chr 4:157,615,386...157,619,541
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Tpra1
transmembrane protein adipocyte associated 1
increases expression
ISO
casticin results in increased expression of TPRA1 mRNA
CTD
PMID:28444820
NCBI chr 4:121,364,093...121,375,275
Ensembl chr 4:121,364,091...121,375,269
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Tra2b
transformer 2 beta
decreases expression
ISO
casticin results in decreased expression of TRA2B mRNA
CTD
PMID:28444820
NCBI chr11:78,788,880...78,807,252
Ensembl chr11:78,788,884...78,807,249
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Trap1
TNF receptor-associated protein 1
increases expression
ISO
casticin results in increased expression of TRAP1 mRNA
CTD
PMID:27862857
NCBI chr10:11,464,882...11,498,931
Ensembl chr10:11,464,821...11,498,981
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Trio
trio Rho guanine nucleotide exchange factor
increases expression
ISO
casticin results in increased expression of TRIO mRNA
CTD
PMID:28444820
NCBI chr 2:78,505,069...78,801,384
Ensembl chr 2:78,505,070...78,803,135
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Ube2d3
ubiquitin-conjugating enzyme E2D 3
decreases expression
ISO
casticin results in decreased expression of UBE2D3 mRNA
CTD
PMID:28444820
NCBI chr 2:223,868,397...223,899,606
Ensembl chr 2:223,868,730...223,898,081
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Ube2f
ubiquitin-conjugating enzyme E2F (putative)
decreases expression
ISO
casticin results in decreased expression of UBE2F mRNA
CTD
PMID:28444820
NCBI chr 9:91,845,975...91,881,145
Ensembl chr 9:91,845,987...91,880,594
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Ube2w
ubiquitin-conjugating enzyme E2W
decreases expression
ISO
casticin results in decreased expression of UBE2W mRNA
CTD
PMID:28444820
NCBI chr 5:2,690,742...2,754,491
Ensembl chr 5:2,690,763...2,814,965
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Vegfa
vascular endothelial growth factor A
decreases expression
ISO
casticin results in decreased expression of VEGFA mRNA
CTD
PMID:28444820
NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
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Vezf1
vascular endothelial zinc finger 1
decreases expression
ISO
casticin results in decreased expression of VEZF1 mRNA
CTD
PMID:28444820
NCBI chr10:72,859,669...72,876,111
Ensembl chr10:72,859,877...72,876,111
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Vim
vimentin
decreases expression increases expression
ISO
casticin results in decreased expression of VIM mRNA casticin results in increased expression of VIM mRNA
CTD
PMID:27862857 PMID:28444820
NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187
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Vldlr
very low density lipoprotein receptor
decreases expression
ISO
casticin results in decreased expression of VLDLR mRNA
CTD
PMID:28444820
NCBI chr 1:224,813,539...224,850,400
Ensembl chr 1:224,814,377...224,845,920
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Wac
WW domain containing adaptor with coiled-coil
decreases expression
ISO
casticin results in decreased expression of WAC mRNA
CTD
PMID:28444820
NCBI chr17:55,922,686...55,984,286
Ensembl chr17:55,923,123...55,982,301
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Wee1
WEE1 G2 checkpoint kinase
decreases expression
ISO
casticin results in decreased expression of WEE1 protein
CTD
PMID:29098808
NCBI chr 1:164,173,681...164,197,688
Ensembl chr 1:164,174,779...164,197,688
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Wnt5a
Wnt family member 5A
decreases expression
ISO
casticin results in decreased expression of WNT5A mRNA
CTD
PMID:27862857
NCBI chr16:3,697,032...3,718,230
Ensembl chr16:3,697,032...3,718,234
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Wsb1
WD repeat and SOCS box-containing 1
decreases expression
ISO
casticin results in decreased expression of WSB1 mRNA
CTD
PMID:28444820
NCBI chr10:64,202,761...64,219,039
Ensembl chr10:64,202,763...64,219,019
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Wtap
WT1 associated protein
decreases expression
ISO
casticin results in decreased expression of WTAP mRNA
CTD
PMID:28444820
NCBI chr 1:47,665,965...47,691,067
Ensembl chr 1:47,665,965...47,691,065
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Xbp1
X-box binding protein 1
increases expression
ISO
casticin results in increased expression of XBP1 mRNA
CTD
PMID:27862857
NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693
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Xiap
X-linked inhibitor of apoptosis
decreases expression
ISO
casticin results in decreased expression of XIAP protein
CTD
PMID:29098808
NCBI chr X:120,890,537...120,938,413
Ensembl chr X:120,897,907...120,934,700
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Ywhab
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta
increases expression
ISO
casticin results in increased expression of YWHAB protein
CTD
PMID:29098808
NCBI chr 3:152,659,663...152,682,105
Ensembl chr 3:152,659,651...152,682,105
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Ywhag
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma
decreases expression
ISO
casticin results in decreased expression of YWHAG mRNA
CTD
PMID:28444820
NCBI chr12:20,744,500...20,772,828
Ensembl chr12:20,744,535...20,772,827
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Zbtb18
zinc finger and BTB domain containing 18
decreases expression
ISO
casticin results in decreased expression of ZBTB18 mRNA
CTD
PMID:28444820
NCBI chr13:89,439,501...89,447,958
Ensembl chr13:89,439,420...89,448,862
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Zfhx4
zinc finger homeobox 4
decreases expression
ISO
casticin results in decreased expression of ZFHX4 mRNA
CTD
PMID:28444820
NCBI chr 2:96,224,763...96,408,245
Ensembl chr 2:96,224,767...96,408,228
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Zfp384
zinc finger protein 384
decreases expression
ISO
casticin results in decreased expression of ZFP384 mRNA
CTD
PMID:28444820
NCBI chr 4:157,810,263...157,840,052
Ensembl chr 4:157,810,352...157,839,766
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Zfp711
zinc finger protein 711
decreases expression
ISO
casticin results in decreased expression of ZFP711 mRNA
CTD
PMID:28444820
NCBI chr X:77,646,300...77,679,398
Ensembl chr X:77,646,558...77,678,045
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Zfr
zinc finger RNA binding protein
decreases expression
ISO
casticin results in decreased expression of ZFR mRNA
CTD
PMID:28444820
NCBI chr 2:61,137,611...61,200,322
Ensembl chr 2:61,137,611...61,200,322
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Zkscan1
zinc finger with KRAB and SCAN domains 1
increases expression
ISO
casticin results in increased expression of ZKSCAN1 mRNA
CTD
PMID:28444820
NCBI chr12:16,966,287...16,987,680
Ensembl chr12:16,966,654...16,983,865
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Zscan2
zinc finger and SCAN domain containing 2
increases expression
ISO
casticin results in increased expression of ZSCAN2 mRNA
CTD
PMID:28444820
NCBI chr 1:134,833,701...134,848,957
Ensembl chr 1:134,833,871...134,848,952
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Zswim6
zinc finger, SWIM-type containing 6
increases expression
ISO
casticin results in increased expression of ZSWIM6 mRNA
CTD
PMID:28444820
NCBI chr 2:39,211,131...39,378,877
Ensembl chr 2:39,212,949...39,378,924
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Cyp2c6
cytochrome P450, family 2, subfamily C, polypeptide 6
decreases activity
ISO
chrysosplenetin results in decreased activity of CYP2C19 protein
CTD
PMID:29753067
NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
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Cyp3a2
cytochrome P450, family 3, subfamily a, polypeptide 2
affects activity
ISO
chrysosplenetin affects the activity of CYP3A4 protein
CTD
PMID:29753067
NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
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Atg12
autophagy related 12
multiple interactions
ISO
gossypetin promotes the reaction [malondialdehyde-low density lipoprotein, human promotes the reaction [ATG5 protein binds to ATG12 protein]]
CTD
PMID:25622137
NCBI chr18:39,452,247...39,462,424
Ensembl chr18:39,452,191...39,462,418
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Atg5
autophagy related 5
multiple interactions
ISO
gossypetin promotes the reaction [malondialdehyde-low density lipoprotein, human promotes the reaction [ATG5 protein binds to ATG12 protein]]
CTD
PMID:25622137
NCBI chr20:47,798,217...47,889,216
Ensembl chr20:47,798,290...47,889,209
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Becn1
beclin 1
multiple interactions increases response to substance
ISO
3-methyladenine inhibits the reaction [gossypetin promotes the reaction [malondialdehyde-low density lipoprotein, human promotes the reaction [BECN1 protein binds to PIK3C3 protein]]]; gossypetin promotes the reaction [malondialdehyde-low density lipoprotein, human promotes the reaction [BECN1 protein binds to PIK3C3 protein]]; gossypetin promotes the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of BECN1 protein] BECN1 protein results in increased susceptibility to gossypetin
CTD
PMID:25622137
NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742
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Casp3
caspase 3
multiple interactions
ISO
gossypetin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased cleavage of CASP3 protein]
CTD
PMID:25622137
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
increases expression
ISO
gossypetin results in increased expression of CYP1A1 mRNA
CTD
PMID:29584932
NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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Mtor
mechanistic target of rapamycin kinase
multiple interactions
ISO
gossypetin promotes the reaction [malondialdehyde-low density lipoprotein, human results in decreased phosphorylation of MTOR protein]
CTD
PMID:25622137
NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
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Parp1
poly (ADP-ribose) polymerase 1
decreases activity multiple interactions
ISO
gossypetin results in decreased activity of PARP1 protein gossypetin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased cleavage of PARP1 protein]
CTD
PMID:17884996 PMID:25622137
NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
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Pik3c3
phosphatidylinositol 3-kinase, catalytic subunit type 3
multiple interactions
ISO
3-methyladenine inhibits the reaction [gossypetin promotes the reaction [malondialdehyde-low density lipoprotein, human promotes the reaction [BECN1 protein binds to PIK3C3 protein]]]; 3-methyladenine inhibits the reaction [gossypetin promotes the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of PIK3C3 protein]]; gossypetin promotes the reaction [malondialdehyde-low density lipoprotein, human promotes the reaction [BECN1 protein binds to PIK3C3 protein]]; gossypetin promotes the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of PIK3C3 protein]
CTD
PMID:25622137
NCBI chr18:21,845,282...21,934,387
Ensembl chr18:21,845,295...21,929,048
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Ppara
peroxisome proliferator activated receptor alpha
affects response to substance
ISO
PPARA protein affects the susceptibility to gossypetin
CTD
PMID:23845592
NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
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Pparg
peroxisome proliferator-activated receptor gamma
affects response to substance
ISO
PPARG protein affects the susceptibility to gossypetin
CTD
PMID:23845592
NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
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Pten
phosphatase and tensin homolog
increases expression multiple interactions
ISO
gossypetin results in increased expression of PTEN protein Enzyme Inhibitors inhibits the reaction [gossypetin results in increased expression of PTEN protein]
CTD
PMID:25622137
NCBI chr 1:230,630,443...230,697,070
Ensembl chr 1:230,630,338...230,696,838
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Sqstm1
sequestosome 1
multiple interactions
ISO
gossypetin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of SQSTM1 protein]
CTD
PMID:25622137
NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673
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Atf1
activating transcription factor 1
multiple interactions decreases phosphorylation
ISO
gossypin inhibits the reaction [EGF protein results in increased phosphorylation of ATF1 protein] gossypin results in decreased phosphorylation of ATF1 protein
CTD
PMID:30536456
NCBI chr 7:131,361,962...131,404,677
Ensembl chr 7:131,362,450...131,404,670
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Aurka
aurora kinase A
multiple interactions
ISO
gossypin binds to and results in decreased activity of AURKA protein
CTD
PMID:30536456
NCBI chr 3:161,128,309...161,144,524
Ensembl chr 3:161,128,313...161,144,390
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Bcl2l1
Bcl2-like 1
decreases expression
ISO
gossypin results in decreased expression of BCL2L1 protein
CTD
PMID:30536456
NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
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Casp3
caspase 3
increases cleavage
ISO
gossypin results in increased cleavage of CASP3 protein
CTD
PMID:30536456
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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Casp7
caspase 7
increases cleavage
ISO
gossypin results in increased cleavage of CASP7 protein
CTD
PMID:30536456
NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729
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Casp9
caspase 9
increases cleavage
ISO
gossypin results in increased cleavage of CASP9 protein
CTD
PMID:30536456
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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Cat
catalase
multiple interactions
EXP
gossypin inhibits the reaction [Lipopolysaccharides results in decreased expression of CAT protein]; gossypin inhibits the reaction [Oleic Acid results in increased activity of CAT protein]
CTD
PMID:37148149 PMID:37696682
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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Ccna2
cyclin A2
decreases expression
ISO
gossypin results in decreased expression of CCNA2 protein
CTD
PMID:30536456
NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577
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Ccnb1
cyclin B1
decreases expression
ISO
gossypin results in decreased expression of CCNB1 protein
CTD
PMID:30536456
NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172
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Cdk1
cyclin-dependent kinase 1
decreases phosphorylation
ISO
gossypin results in decreased phosphorylation of CDK1 protein
CTD
PMID:30536456
NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408
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Crp
C-reactive protein
multiple interactions
EXP
gossypin inhibits the reaction [Lipopolysaccharides results in increased expression of CRP protein]
CTD
PMID:37148149
NCBI chr13:85,135,384...85,175,178
Ensembl chr13:85,124,977...85,175,178
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Egf
epidermal growth factor
multiple interactions
ISO
gossypin inhibits the reaction [EGF protein results in increased phosphorylation of ATF1 protein]
CTD
PMID:30536456
NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064
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Hmox1
heme oxygenase 1
multiple interactions
EXP
gossypin inhibits the reaction [Lipopolysaccharides results in decreased expression of HMOX1 protein]
CTD
PMID:37148149
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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Il10
interleukin 10
multiple interactions
EXP
gossypin inhibits the reaction [Lipopolysaccharides results in decreased expression of IL10 protein]
CTD
PMID:37148149
NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
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Il13
interleukin 13
multiple interactions
EXP
gossypin inhibits the reaction [Lipopolysaccharides results in increased expression of IL13 protein]
CTD
PMID:37148149
NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737
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Il17a
interleukin 17A
multiple interactions
EXP
gossypin inhibits the reaction [Lipopolysaccharides results in increased expression of IL17A protein]
CTD
PMID:37148149
NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889
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Il18
interleukin 18
multiple interactions
EXP
gossypin inhibits the reaction [Lipopolysaccharides results in increased expression of IL18 protein]
CTD
PMID:37148149
NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
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Il1b
interleukin 1 beta
multiple interactions
EXP
gossypin inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]; gossypin inhibits the reaction [Oleic Acid results in increased expression of IL1B mRNA]
CTD
PMID:37148149 PMID:37696682
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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Il4
interleukin 4
multiple interactions
EXP
gossypin inhibits the reaction [Lipopolysaccharides results in decreased expression of IL4 protein]
CTD
PMID:37148149
NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
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Il5
interleukin 5
multiple interactions
EXP
gossypin inhibits the reaction [Lipopolysaccharides results in increased expression of IL5 protein]
CTD
PMID:37148149
NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213
G
Il6
interleukin 6
multiple interactions
EXP
gossypin inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]; gossypin inhibits the reaction [Oleic Acid results in increased expression of IL6 mRNA]
CTD
PMID:37148149 PMID:37696682
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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Jun
Jun proto-oncogene, AP-1 transcription factor subunit
decreases phosphorylation
ISO
gossypin results in decreased phosphorylation of JUN protein
CTD
PMID:30536456
NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
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Mpo
myeloperoxidase
multiple interactions
EXP
gossypin inhibits the reaction [Lipopolysaccharides results in increased expression of MPO protein]
CTD
PMID:37148149
NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819
G
Nfe2l2
NFE2 like bZIP transcription factor 2
multiple interactions
EXP
gossypin inhibits the reaction [Lipopolysaccharides results in decreased expression of NFE2L2 protein]
CTD
PMID:37148149
NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
G
Parp1
poly (ADP-ribose) polymerase 1
increases cleavage
ISO
gossypin results in increased cleavage of PARP1 protein
CTD
PMID:30536456
NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
G
Ptgs2
prostaglandin-endoperoxide synthase 2
multiple interactions
EXP
gossypin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]
CTD
PMID:37148149
NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
G
Rps6ka3
ribosomal protein S6 kinase A3
multiple interactions
ISO
gossypin binds to and results in decreased activity of RPS6KA3 protein
CTD
PMID:30536456
NCBI chr X:35,517,306...35,623,296
Ensembl chr X:35,517,306...35,623,207
G
Tgfb1
transforming growth factor, beta 1
multiple interactions
EXP
gossypin inhibits the reaction [Lipopolysaccharides results in increased expression of TGFB1 protein]
CTD
PMID:37148149
NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
G
Tnf
tumor necrosis factor
multiple interactions
EXP
gossypin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; gossypin inhibits the reaction [Oleic Acid results in increased expression of TNF mRNA]; gossypin inhibits the reaction [Oleic Acid results in increased expression of TNF protein]
CTD
PMID:37148149 PMID:37696682
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
G
Abcb1a
ATP binding cassette subfamily B member 1A
increases expression multiple interactions increases activity
ISO
myricetin results in increased expression of ABCB1 protein myricetin inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123] myricetin results in increased activity of ABCB1 protein
CTD
PMID:34217736
NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
G
Abcc1
ATP binding cassette subfamily C member 1
decreases activity multiple interactions
ISO
myricetin results in decreased activity of ABCC1 protein myricetin inhibits the reaction [ABCC1 protein affects the export of and results in decreased susceptibility to Vincristine]; myricetin inhibits the reaction [ABCC1 protein affects the export of Vincristine]; myricetin inhibits the reaction [ABCC1 protein results in decreased susceptibility to Vincristine]; myricetin inhibits the reaction [ABCC1 protein results in increased uptake of Leukotriene C4]
CTD
PMID:11306701 PMID:15670588 PMID:15896345
NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114
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Abcc2
ATP binding cassette subfamily C member 2
multiple interactions decreases activity
ISO
myricetin inhibits the reaction [ABCC2 protein affects the export of and results in decreased susceptibility to Vincristine]; myricetin inhibits the reaction [ABCC2 protein affects the export of Vincristine]; myricetin inhibits the reaction [ABCC2 protein results in decreased susceptibility to Vincristine] myricetin results in decreased activity of ABCC2 protein
CTD
PMID:15670588 PMID:15896345
NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
G
Afp
alpha-fetoprotein
affects binding
EXP
myricetin binds to AFP protein
CTD
PMID:23013281 PMID:25349334
NCBI chr14:17,573,412...17,591,476
Ensembl chr14:17,573,412...17,591,480
G
Alb
albumin
multiple interactions
EXP
myricetin inhibits the reaction [[Streptozocin co-treated with Cadmium] results in increased expression of ALB protein]
CTD
PMID:24923654 PMID:25240712
NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
G
Arhgdib
Rho GDP dissociation inhibitor beta
increases cleavage
ISO
myricetin results in increased cleavage of ARHGDIB protein
CTD
PMID:15748703
NCBI chr 4:169,822,951...169,841,884
Ensembl chr 4:169,822,952...169,841,658
G
Atr
ATR serine/threonine kinase
multiple interactions
ISO
myricetin affects the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine affects the expression of ATR mRNA]
CTD
PMID:32342131
NCBI chr 8:96,426,704...96,524,152
Ensembl chr 8:96,426,724...96,524,136
G
Bax
BCL2 associated X, apoptosis regulator
decreases expression multiple interactions
ISO
myricetin results in decreased expression of BAX protein Tetradecanoylphorbol Acetate inhibits the reaction [myricetin results in decreased expression of BAX protein]
CTD
PMID:15748703
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
G
Bcl2
BCL2, apoptosis regulator
decreases expression multiple interactions
ISO
myricetin results in decreased expression of BCL2 protein Tetradecanoylphorbol Acetate inhibits the reaction [myricetin results in decreased expression of BCL2 protein]
CTD
PMID:15748703 PMID:29698783
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
G
Casp3
caspase 3
increases activity increases cleavage
ISO
myricetin results in increased activity of CASP3 protein myricetin results in increased cleavage of CASP3 protein
CTD
PMID:15748703 PMID:19397994 PMID:29698783
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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Casp8
caspase 8
decreases expression
ISO
myricetin results in decreased expression of CASP8 protein
CTD
PMID:29698783
NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
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Casp9
caspase 9
increases activity increases cleavage
ISO
myricetin results in increased activity of CASP9 protein myricetin results in increased cleavage of CASP9 protein
CTD
PMID:15748703 PMID:29698783
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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Cat
catalase
multiple interactions
ISO EXP
myricetin inhibits the reaction [Rotenone results in increased activity of CAT protein] myricetin inhibits the reaction [Ethanol results in decreased activity of CAT protein]
CTD
PMID:15904944 PMID:35156864
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
G
Ccnb1
cyclin B1
decreases expression
ISO
myricetin results in decreased expression of CCNB1 mRNA; myricetin results in decreased expression of CCNB1 protein
CTD
PMID:19397994
NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172
G
Cdkn1a
cyclin-dependent kinase inhibitor 1A
increases expression
ISO
myricetin results in increased expression of CDKN1A mRNA; myricetin results in increased expression of CDKN1A protein
CTD
PMID:19397994
NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
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Cdkn2c
cyclin-dependent kinase inhibitor 2C
increases expression
ISO
myricetin results in increased expression of CDKN2C mRNA
CTD
PMID:18331776
NCBI chr 5:124,411,123...124,416,278
Ensembl chr 5:124,411,124...124,416,278
G
Cfl1
cofilin 1
increases expression
ISO
myricetin results in increased expression of CFL1 protein
CTD
PMID:29698783
NCBI chr 1:202,796,012...202,801,337
Ensembl chr 1:202,786,627...202,817,587
G
Cldn1
claudin 1
multiple interactions
EXP
myricetin inhibits the reaction [Indomethacin results in decreased expression of CLDN1 mRNA]; myricetin inhibits the reaction [Indomethacin results in decreased expression of CLDN1 protein]
CTD
PMID:33276066
NCBI chr11:74,421,569...74,436,728
Ensembl chr11:74,421,569...74,436,724
G
Comt
catechol-O-methyltransferase
multiple interactions
ISO
[myricetin co-treated with COMT protein] results in decreased activity of DNMT1 protein
CTD
PMID:16037419
NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642
G
Cox5b
cytochrome c oxidase subunit 5B
increases expression
ISO
myricetin results in increased expression of COX5B protein
CTD
PMID:29698783
NCBI chr 9:38,921,980...38,923,806
Ensembl chr 9:38,921,967...38,925,052
G
Ctnnb1
catenin beta 1
decreases expression multiple interactions
ISO
myricetin results in decreased expression of CTNNB1 protein [myricetin results in increased activity of SIRT1 protein] which results in decreased expression of CTNNB1 protein
CTD
PMID:22245592
NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
G
Cycs
cytochrome c, somatic
affects localization multiple interactions
ISO
myricetin affects the localization of CYCS protein Tetradecanoylphorbol Acetate inhibits the reaction [myricetin affects the localization of CYCS protein]
CTD
PMID:15748703
NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054 Ensembl chr18:79,651,378...79,654,054
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Cyp11a1
cytochrome P450, family 11, subfamily a, polypeptide 1
multiple interactions
ISO
myricetin promotes the reaction [Cyclic AMP results in increased expression of CYP11A1 mRNA]
CTD
PMID:28668616
NCBI chr 8:58,422,807...58,434,342
Ensembl chr 8:58,404,669...58,434,338
G
Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
decreases activity increases expression multiple interactions
ISO
myricetin results in decreased activity of CYP1A1 protein myricetin results in increased expression of CYP1A1 mRNA myricetin inhibits the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]
CTD
PMID:16271822 PMID:20930378 PMID:21482471 PMID:29584932
NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
G
Cyp1a2
cytochrome P450, family 1, subfamily a, polypeptide 2
decreases activity
ISO
myricetin results in decreased activity of CYP1A2 protein
CTD
PMID:29753067
NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
G
Cyp1b1
cytochrome P450, family 1, subfamily b, polypeptide 1
decreases activity
ISO
myricetin results in decreased activity of CYP1B1 protein
CTD
PMID:16271822 PMID:21482471
NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
G
Cyp2c6
cytochrome P450, family 2, subfamily C, polypeptide 6
decreases activity
ISO
myricetin results in decreased activity of CYP2C19 protein
CTD
PMID:29753067
NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
G
Cyp2d4
cytochrome P450, family 2, subfamily d, polypeptide 4
decreases activity
ISO
myricetin results in decreased activity of CYP2D6 protein
CTD
PMID:29753067
NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
G
Cyp2e1
cytochrome P450, family 2, subfamily e, polypeptide 1
decreases activity
ISO
myricetin results in decreased activity of CYP2E1 protein
CTD
PMID:29753067
NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
G
Cyp3a2
cytochrome P450, family 3, subfamily a, polypeptide 2
decreases activity
ISO
myricetin results in decreased activity of CYP3A4 protein
CTD
PMID:29753067
NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
G
Dnmt1
DNA methyltransferase 1
multiple interactions decreases activity
ISO
[myricetin co-treated with COMT protein] results in decreased activity of DNMT1 protein myricetin results in decreased activity of DNMT1 protein
CTD
PMID:16037419
NCBI chr 8:19,440,611...19,486,659
Ensembl chr 8:19,440,611...19,486,659
G
Egf
epidermal growth factor
multiple interactions
ISO
myricetin inhibits the reaction [EGF protein results in increased expression of FOS mRNA]; myricetin inhibits the reaction [EGF protein results in increased expression of STAT3 mRNA]; myricetin inhibits the reaction [EGF protein results in increased phosphorylation of JAK1 protein]; myricetin inhibits the reaction [EGF protein results in increased phosphorylation of MAPK1 protein]; myricetin inhibits the reaction [EGF protein results in increased phosphorylation of MAPK3 protein]; myricetin inhibits the reaction [EGF protein results in increased phosphorylation of MAPK9 protein]; myricetin inhibits the reaction [EGF protein results in increased phosphorylation of RPS6KA1 protein]; myricetin inhibits the reaction [EGF protein results in increased phosphorylation of STAT3 protein]; myricetin promotes the reaction [EGF protein results in increased phosphorylation of EGFR protein]
CTD
PMID:17693661 PMID:18995957
NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064
G
Egfr
epidermal growth factor receptor
multiple interactions decreases phosphorylation
ISO
myricetin promotes the reaction [EGF protein results in increased phosphorylation of EGFR protein] myricetin results in decreased phosphorylation of EGFR protein
CTD
PMID:18995957
NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382
G
Egln1
egl-9 family hypoxia-inducible factor 1
decreases expression multiple interactions
ISO
myricetin results in decreased expression of EGLN1 protein [myricetin results in increased activity of SIRT1 protein] which results in decreased expression of EGLN1 protein
CTD
PMID:22245592
NCBI chr19:52,867,900...52,907,308
Ensembl chr19:52,869,486...52,907,777
G
Ep300
E1A binding protein p300
multiple interactions
ISO
myricetin promotes the reaction [Oxygen deficiency promotes the reaction [HIF1A protein binds to EP300 protein]]
CTD
PMID:20153296
NCBI chr 7:113,108,476...113,178,529
Ensembl chr 7:113,106,247...113,136,088 Ensembl chr 7:113,106,247...113,136,088
G
Fbp1
fructose-bisphosphatase 1
decreases expression
ISO
myricetin results in decreased expression of FBP1 mRNA
CTD
PMID:18331776
NCBI chr17:2,207,271...2,230,076
Ensembl chr17:2,208,031...2,230,071
G
Fdx1
ferredoxin 1
multiple interactions
ISO
myricetin promotes the reaction [Cyclic AMP results in increased expression of FDX1 mRNA]
CTD
PMID:28668616
NCBI chr 8:52,268,536...52,287,344
Ensembl chr 8:52,268,536...52,287,414
G
Fn1
fibronectin 1
multiple interactions
EXP
myricetin inhibits the reaction [[Streptozocin co-treated with Cadmium] results in increased expression of FN1 protein]
CTD
PMID:25240712
NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678
G
Fos
Fos proto-oncogene, AP-1 transcription factor subunit
multiple interactions
ISO
myricetin inhibits the reaction [EGF protein results in increased expression of FOS mRNA]; myricetin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of FOS mRNA]
CTD
PMID:17693661
NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
G
G6pd
glucose-6-phosphate dehydrogenase
multiple interactions
EXP
myricetin inhibits the reaction [[Streptozocin co-treated with Cadmium] results in decreased activity of G6PD protein]
CTD
PMID:24923654
NCBI chr X:152,201,081...152,220,863
Ensembl chr X:152,201,098...152,220,801
G
Gpt
glutamic--pyruvic transaminase
multiple interactions
EXP
myricetin inhibits the reaction [Ethanol results in increased activity of GPT protein]
CTD
PMID:35156864
NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
G
Gsr
glutathione-disulfide reductase
multiple interactions
EXP
myricetin inhibits the reaction [Ethanol results in decreased activity of GSR protein]
CTD
PMID:35156864
NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
G
H2ax
H2A.X variant histone
multiple interactions
ISO
myricetin inhibits the reaction [Doxorubicin results in increased expression of H2AX protein]
CTD
PMID:32107588
NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239
G
Hbegf
heparin-binding EGF-like growth factor
multiple interactions
ISO
myricetin affects the reaction [Sodium Chloride results in increased expression of HBEGF mRNA]
CTD
PMID:26800359
NCBI chr18:28,106,284...28,116,167
Ensembl chr18:28,105,760...28,116,441
G
Hgf
hepatocyte growth factor
multiple interactions
ISO
myricetin inhibits the reaction [HGF protein results in increased phosphorylation of MET protein]
CTD
PMID:19244381
NCBI chr 4:18,673,736...18,745,582
Ensembl chr 4:18,677,101...18,745,409
G
Hif1a
hypoxia inducible factor 1 subunit alpha
increases expression decreases activity multiple interactions
ISO
myricetin results in increased expression of HIF1A protein myricetin results in decreased activity of HIF1A protein [myricetin results in increased activity of SIRT1 protein] which results in increased expression of HIF1A protein; Deferoxamine inhibits the reaction [myricetin inhibits the reaction [Formaldehyde results in increased expression of HIF1A mRNA]]; Deferoxamine inhibits the reaction [myricetin inhibits the reaction [Formaldehyde results in increased expression of HIF1A protein]]; myricetin inhibits the reaction [Formaldehyde results in increased expression of HIF1A mRNA]; myricetin inhibits the reaction [Formaldehyde results in increased expression of HIF1A protein]; myricetin promotes the reaction [Oxygen deficiency promotes the reaction [HIF1A protein binds to EP300 protein]]
CTD
PMID:19958256 PMID:20153296 PMID:22245592 PMID:36116563
NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
G
Hk2
hexokinase 2
multiple interactions
ISO
Deferoxamine inhibits the reaction [myricetin inhibits the reaction [Formaldehyde results in increased expression of HK2 mRNA]]; Deferoxamine inhibits the reaction [myricetin inhibits the reaction [Formaldehyde results in increased expression of HK2 protein]]; myricetin inhibits the reaction [Formaldehyde results in increased expression of HK2 mRNA]; myricetin inhibits the reaction [Formaldehyde results in increased expression of HK2 protein]
CTD
PMID:36116563
NCBI chr 4:115,234,509...115,283,530
Ensembl chr 4:115,234,509...115,283,530
G
Hmgcr
3-hydroxy-3-methylglutaryl-CoA reductase
multiple interactions
EXP
myricetin inhibits the reaction [[Streptozocin co-treated with Cadmium] results in increased activity of HMGCR protein]
CTD
PMID:25240712
NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703
G
Hmox1
heme oxygenase 1
increases expression
ISO
myricetin results in increased expression of HMOX1 protein
CTD
PMID:16799064
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
G
Hras
HRas proto-oncogene, GTPase
decreases activity
ISO
myricetin results in decreased activity of HRAS protein
CTD
PMID:17693661
NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615
G
Il6
interleukin 6
multiple interactions
ISO EXP
myricetin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased secretion of IL6 protein] myricetin inhibits the reaction [Ethanol results in increased expression of IL6 protein]
CTD
PMID:18958421 PMID:35156864
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
G
Ins1
insulin 1
multiple interactions
EXP
myricetin inhibits the reaction [[Streptozocin co-treated with Cadmium] results in decreased expression of INS1 protein]
CTD
PMID:24923654
NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536
G
Irs1
insulin receptor substrate 1
multiple interactions
EXP
myricetin inhibits the reaction [[Streptozocin co-treated with Cadmium] results in decreased expression of IRS1 protein]
CTD
PMID:24923654
NCBI chr 9:83,552,964...83,605,797
Ensembl chr 9:83,548,944...83,606,122
G
Irs2
insulin receptor substrate 2
multiple interactions
EXP
myricetin inhibits the reaction [[Streptozocin co-treated with Cadmium] results in decreased expression of IRS2 protein]
CTD
PMID:24923654
NCBI chr16:78,488,249...78,512,482
Ensembl chr16:78,485,045...78,512,482
G
Jak1
Janus kinase 1
affects binding multiple interactions
ISO
myricetin binds to JAK1 protein myricetin inhibits the reaction [EGF protein results in increased phosphorylation of JAK1 protein]
CTD
PMID:18995957
NCBI chr 5:115,780,248...115,888,841
Ensembl chr 5:115,780,248...115,888,926
G
Lcat
lecithin cholesterol acyltransferase
multiple interactions
EXP
myricetin inhibits the reaction [[Streptozocin co-treated with Cadmium] results in decreased activity of LCAT protein]
CTD
PMID:25240712
NCBI chr19:33,834,748...33,838,214
Ensembl chr19:33,834,403...33,838,231
G
Ldha
lactate dehydrogenase A
multiple interactions
ISO
Deferoxamine inhibits the reaction [myricetin inhibits the reaction [Formaldehyde results in increased expression of LDHA mRNA]]; Deferoxamine inhibits the reaction [myricetin inhibits the reaction [Formaldehyde results in increased expression of LDHA protein]]; myricetin inhibits the reaction [Formaldehyde results in increased expression of LDHA mRNA]; myricetin inhibits the reaction [Formaldehyde results in increased expression of LDHA protein]
CTD
PMID:36116563
NCBI chr 1:97,371,823...97,381,247
Ensembl chr 1:97,366,021...97,433,472
G
Lpl
lipoprotein lipase
multiple interactions
EXP
myricetin inhibits the reaction [[Streptozocin co-treated with Cadmium] results in decreased activity of LPL protein]
CTD
PMID:25240712
NCBI chr16:20,830,055...20,853,855
Ensembl chr16:20,829,465...20,855,249
G
Ltf
lactotransferrin
increases expression
EXP
myricetin results in increased expression of LTF protein
CTD
PMID:24487097
NCBI chr 8:110,999,948...111,022,795
Ensembl chr 8:110,999,948...111,022,795
G
Ltn1
listerin E3 ubiquitin protein ligase 1
decreases expression
ISO
myricetin results in decreased expression of LTN1 protein
CTD
PMID:29698783
NCBI chr11:26,603,903...26,660,871
Ensembl chr11:26,603,903...26,660,886
G
Map2k1
mitogen activated protein kinase kinase 1
multiple interactions
ISO
myricetin binds to and results in decreased activity of MAP2K1 protein; myricetin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of MAP2K1 protein]
CTD
PMID:17693661
NCBI chr 8:64,683,449...64,754,900
Ensembl chr 8:64,683,449...64,755,147
G
Map3k7
mitogen activated protein kinase kinase kinase 7
decreases phosphorylation
ISO
Myricetin decreases phosphorylation of Map3k7 protein in the heart
RGD
PMID:31885808
RGD:155791644
NCBI chr 5:46,356,973...46,415,597
Ensembl chr 5:46,357,931...46,415,597
G
Mapk1
mitogen activated protein kinase 1
multiple interactions decreases activity
ISO
myricetin inhibits the reaction [EGF protein results in increased phosphorylation of MAPK1 protein]; myricetin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK1 protein] myricetin results in decreased activity of MAPK1 protein
CTD
PMID:17693661
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
G
Mapk3
mitogen activated protein kinase 3
multiple interactions
ISO
myricetin inhibits the reaction [EGF protein results in increased phosphorylation of MAPK3 protein]; myricetin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK3 protein]
CTD
PMID:17693661
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
G
Mapk9
mitogen-activated protein kinase 9
multiple interactions
ISO
myricetin inhibits the reaction [EGF protein results in increased phosphorylation of MAPK9 protein]; myricetin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK9 protein]
CTD
PMID:17693661
NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178
G
Met
MET proto-oncogene, receptor tyrosine kinase
multiple interactions
ISO
myricetin inhibits the reaction [HGF protein results in increased phosphorylation of MET protein]
CTD
PMID:19244381
NCBI chr 4:45,790,456...45,898,139
Ensembl chr 4:45,790,791...45,897,876
G
Mmp9
matrix metallopeptidase 9
multiple interactions
ISO
myricetin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of MMP9 protein]
CTD
PMID:19804834
NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
G
Myc
MYC proto-oncogene, bHLH transcription factor
decreases expression multiple interactions
ISO
myricetin results in decreased expression of MYC protein [myricetin results in increased activity of SIRT1 protein] which results in decreased expression of MYC protein
CTD
PMID:22245592
NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
G
Nfe2l2
NFE2 like bZIP transcription factor 2
increases expression
ISO
myricetin results in increased expression of NFE2L2 protein
CTD
PMID:16799064
NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
G
Nme1
NME/NM23 nucleoside diphosphate kinase 1
increases expression
ISO
myricetin results in increased expression of NME1 protein
CTD
PMID:29698783
NCBI chr10:78,907,036...78,929,659
Ensembl chr10:78,906,083...78,916,408
G
Ocln
occludin
multiple interactions
EXP
myricetin inhibits the reaction [Indomethacin results in decreased expression of OCLN mRNA]; myricetin inhibits the reaction [Indomethacin results in decreased expression of OCLN protein]
CTD
PMID:33276066
NCBI chr 2:31,657,217...31,707,466
Ensembl chr 2:31,657,220...31,764,150
G
Parg
poly (ADP-ribose) glycohydrolase
decreases activity
ISO
myricetin results in decreased activity of PARG protein
CTD
PMID:19840838
NCBI chr16:7,436,429...7,544,276
Ensembl chr16:7,436,476...7,544,273
G
Parp1
poly (ADP-ribose) polymerase 1
increases cleavage decreases activity
ISO
myricetin results in increased cleavage of PARP1 protein myricetin results in decreased activity of PARP1 protein
CTD
PMID:15748703 PMID:17884996 PMID:29698783
NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
G
Pik3c2b
phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
decreases expression
ISO
myricetin results in decreased expression of PIK3C2B protein
CTD
PMID:29698783
NCBI chr13:44,494,673...44,555,663
Ensembl chr13:44,495,050...44,555,612
G
Ppara
peroxisome proliferator activated receptor alpha
multiple interactions
EXP
myricetin inhibits the reaction [[Streptozocin co-treated with Cadmium] results in increased expression of PPARA protein]
CTD
PMID:25240712
NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
G
Psca
prostate stem cell antigen
decreases expression
ISO
myricetin results in decreased expression of PSCA mRNA
CTD
PMID:18331776
NCBI chr 7:106,598,203...106,603,114
Ensembl chr 7:106,595,284...106,609,746
G
Ptgs2
prostaglandin-endoperoxide synthase 2
multiple interactions
ISO
myricetin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 protein] myricetin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 mRNA]; myricetin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 protein]
CTD
PMID:17944529 PMID:19804834
NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
G
Rela
RELA proto-oncogene, NF-kB subunit
multiple interactions
ISO
myricetin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] affects the localization of and results in increased activity of RELA protein]
CTD
PMID:18958421
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
G
Rps12
ribosomal protein S12
decreases expression
ISO
myricetin results in decreased expression of RPS12 protein
CTD
PMID:29698783
NCBI chr 1:21,680,854...21,683,010
Ensembl chr 1:21,680,852...21,683,014
G
Rps6ka1
ribosomal protein S6 kinase A1
multiple interactions
ISO
myricetin inhibits the reaction [EGF protein results in increased phosphorylation of RPS6KA1 protein]; myricetin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of RPS6KA1 protein]
CTD
PMID:17693661
NCBI chr 5:146,079,018...146,118,272
Ensembl chr 5:146,079,021...146,118,272
G
Rps6kb2
ribosomal protein S6 kinase B2
increases expression
ISO
myricetin results in increased expression of RPS6KB2 protein
CTD
PMID:29698783
NCBI chr 1:201,451,265...201,458,096
Ensembl chr 1:201,451,265...201,458,078
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Sirt1
sirtuin 1
increases activity increases expression multiple interactions
ISO
myricetin results in increased activity of SIRT1 protein myricetin results in increased expression of SIRT1 protein [myricetin results in increased activity of SIRT1 protein] which results in decreased expression of CTNNB1 protein; [myricetin results in increased activity of SIRT1 protein] which results in decreased expression of EGLN1 protein; [myricetin results in increased activity of SIRT1 protein] which results in decreased expression of MYC protein; [myricetin results in increased activity of SIRT1 protein] which results in increased expression of HIF1A protein
CTD
PMID:22245592
NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260
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Slc2a1
solute carrier family 2 member 1
multiple interactions decreases activity
ISO
Deferoxamine inhibits the reaction [myricetin inhibits the reaction [Formaldehyde results in increased expression of SLC2A1 mRNA]]; Deferoxamine inhibits the reaction [myricetin inhibits the reaction [Formaldehyde results in increased expression of SLC2A1 protein]]; myricetin inhibits the reaction [Formaldehyde results in increased expression of SLC2A1 mRNA]; myricetin inhibits the reaction [Formaldehyde results in increased expression of SLC2A1 protein]; myricetin inhibits the reaction [SLC2A1 protein affects the transport of Glucose] myricetin results in decreased activity of SLC2A1 protein
CTD
PMID:14642735 PMID:36116563
NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416
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Slc2a2
solute carrier family 2 member 2
multiple interactions
EXP
myricetin inhibits the reaction [[Streptozocin co-treated with Cadmium] results in decreased expression of SLC2A2 protein]
CTD
PMID:24923654
NCBI chr 2:111,609,798...111,639,930
Ensembl chr 2:111,611,774...111,639,933
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Src
SRC proto-oncogene, non-receptor tyrosine kinase
multiple interactions
EXP
myricetin inhibits the reaction [Indomethacin results in increased phosphorylation of SRC protein]
CTD
PMID:33276066
NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476
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Srebf1
sterol regulatory element binding transcription factor 1
multiple interactions
EXP
myricetin inhibits the reaction [[Streptozocin co-treated with Cadmium] results in increased expression of SREBF1 protein]
CTD
PMID:25240712
NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650
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Srebf2
sterol regulatory element binding transcription factor 2
multiple interactions
EXP
myricetin inhibits the reaction [[Streptozocin co-treated with Cadmium] results in increased expression of SREBF2 protein]
CTD
PMID:25240712
NCBI chr 7:113,663,202...113,720,850
Ensembl chr 7:113,663,202...113,720,848
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Star
steroidogenic acute regulatory protein
multiple interactions
ISO
myricetin promotes the reaction [Cyclic AMP results in increased expression of STAR mRNA]
CTD
PMID:28668616
NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672
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Stat3
signal transducer and activator of transcription 3
multiple interactions
ISO
myricetin inhibits the reaction [EGF protein results in increased expression of STAT3 mRNA]; myricetin inhibits the reaction [EGF protein results in increased phosphorylation of STAT3 protein]
CTD
PMID:18995957
NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
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Stk38l
serine/threonine kinase 38 like
decreases expression
ISO
myricetin results in decreased expression of STK38L protein
CTD
PMID:29698783
NCBI chr 4:179,616,288...179,693,177
Ensembl chr 4:179,634,275...179,690,983
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Tgfb1
transforming growth factor, beta 1
multiple interactions
EXP
myricetin inhibits the reaction [[Streptozocin co-treated with Cadmium] results in increased expression of TGFB1 protein]
CTD
PMID:25240712
NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
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Tjp1
tight junction protein 1
multiple interactions
EXP
myricetin inhibits the reaction [Indomethacin results in decreased expression of TJP1 mRNA]; myricetin inhibits the reaction [Indomethacin results in decreased expression of TJP1 protein]
CTD
PMID:33276066
NCBI chr 1:118,849,838...119,094,492
Ensembl chr 1:118,849,838...119,094,432
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Tnf
tumor necrosis factor
multiple interactions
ISO EXP
myricetin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased secretion of TNF protein] myricetin inhibits the reaction [Ethanol results in increased expression of TNF protein]
CTD
PMID:18958421 PMID:35156864
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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Top2a
DNA topoisomerase II alpha
decreases activity
ISO
myricetin results in decreased activity of TOP2A protein
CTD
PMID:16536579
NCBI chr10:83,945,731...83,976,874
Ensembl chr10:83,945,735...83,976,874
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Tp53
tumor protein p53
increases expression multiple interactions
ISO
myricetin analog results in increased expression of TP53 mRNA; myricetin analog results in increased expression of TP53 protein; myricetin results in increased expression of TP53 protein myricetin affects the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine affects the expression of TP53 mRNA]
CTD
PMID:32220605 PMID:32342131
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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Tp53i3
tumor protein p53 inducible protein 3
increases expression
ISO
myricetin results in increased expression of TP53I3 mRNA; myricetin results in increased expression of TP53I3 protein
CTD
PMID:19397994
NCBI chr 6:27,818,327...27,825,753
G
Tp63
tumor protein p63
increases expression
ISO
myricetin results in increased expression of TP63 protein
CTD
PMID:19397994
NCBI chr11:74,838,858...75,049,764
Ensembl chr11:74,838,859...75,049,398
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Tp73
tumor protein p73
increases expression
ISO
myricetin results in increased expression of TP73 protein
CTD
PMID:19397994
NCBI chr 5:164,621,377...164,703,958
Ensembl chr 5:164,621,377...164,681,128
G
Txnrd1
thioredoxin reductase 1
decreases activity multiple interactions
EXP
myricetin results in decreased activity of TXNRD1 protein modified form [Xanthine co-treated with XDH protein] promotes the reaction [myricetin results in decreased activity of TXNRD1 protein modified form]; Nitrogen inhibits the reaction [myricetin results in decreased activity of TXNRD1 protein modified form]
CTD
PMID:16618767
NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863
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Ugt1a1
UDP glucuronosyltransferase family 1 member A1
decreases activity
ISO
myricetin results in decreased activity of UGT1A1 protein
CTD
PMID:35063619
NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465
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Ugt1a2
UDP glucuronosyltransferase 1 family, polypeptide A2
decreases activity
ISO
myricetin results in decreased activity of UGT1A3 protein
CTD
PMID:35063619
NCBI chr 9:88,791,216...88,808,465
Ensembl chr 9:88,713,184...88,808,465
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Ugt1a6
UDP glucuronosyltransferase family 1 member A6
decreases activity
ISO
myricetin results in decreased activity of UGT1A6 protein
CTD
PMID:35063619
NCBI chr 9:88,747,213...88,808,465
Ensembl chr 9:88,713,184...88,808,465
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Ugt1a9
UDP glucuronosyltransferase family 1 member A9
decreases activity
ISO
myricetin results in decreased activity of UGT1A9 protein
CTD
PMID:35063619
NCBI chr 9:88,696,981...88,808,465
Ensembl chr 9:88,713,184...88,808,465
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Ugt2b7
UDP glucuronosyltransferase family 2 member B7
decreases activity
ISO
myricetin results in decreased activity of UGT2B7 protein
CTD
PMID:35063619
NCBI chr14:20,896,682...20,919,604
Ensembl chr14:20,896,682...20,919,604
G
Vegfa
vascular endothelial growth factor A
multiple interactions
EXP ISO
myricetin inhibits the reaction [[Streptozocin co-treated with Cadmium] results in increased expression of VEGFA protein] myricetin inhibits the reaction [cobaltous chloride results in increased expression of VEGFA mRNA]; myricetin promotes the reaction [Oxygen deficiency results in increased secretion of VEGFA protein]
CTD
PMID:20153296 PMID:25240712 PMID:26800359
NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
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Xdh
xanthine dehydrogenase
multiple interactions
EXP
[Xanthine co-treated with XDH protein] promotes the reaction [myricetin results in decreased activity of TXNRD1 protein modified form]; myricetin inhibits the reaction [Ethanol results in increased activity of XDH protein]
CTD
PMID:16618767 PMID:35156864
NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268
G
Acta2
actin alpha 2, smooth muscle
multiple interactions
ISO
myricitrin inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein]
CTD
PMID:25656916
NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
G
Alpl
alkaline phosphatase, biomineralization associated
multiple interactions
ISO
myricitrin inhibits the reaction [Hydrogen Peroxide results in decreased expression of ALPL mRNA]
CTD
PMID:25130202
NCBI chr 5:149,951,397...150,006,424
Ensembl chr 5:149,951,409...150,006,446
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Apoe
apolipoprotein E
multiple interactions
ISO
myricitrin inhibits the reaction [APOE gene mutant form results in decreased activity of CAT protein]; myricitrin inhibits the reaction [APOE gene mutant form results in increased activity of CASP3 protein]; myricitrin inhibits the reaction [APOE gene mutant form results in increased expression of CCL2 protein]; myricitrin inhibits the reaction [APOE gene mutant form results in increased expression of CRP protein]; myricitrin inhibits the reaction [APOE gene mutant form results in increased expression of ICAM1 protein]
CTD
PMID:23639522
NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932
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Bax
BCL2 associated X, apoptosis regulator
multiple interactions
ISO
myricitrin inhibits the reaction [Hydrogen Peroxide results in increased expression of BAX protein]
CTD
PMID:23639522
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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Bcl2
BCL2, apoptosis regulator
multiple interactions
ISO
myricitrin inhibits the reaction [Hydrogen Peroxide results in decreased expression of BCL2 protein]
CTD
PMID:23639522
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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Bglap
bone gamma-carboxyglutamate protein
multiple interactions
ISO
myricitrin inhibits the reaction [Hydrogen Peroxide results in decreased expression of BGLAP mRNA]
CTD
PMID:25130202
NCBI chr 2:173,838,518...173,839,495
Ensembl chr 2:173,838,518...173,839,495
G
Casp3
caspase 3
multiple interactions
ISO
myricitrin inhibits the reaction [Hydrogen Peroxide results in increased activity of CASP3 protein] myricitrin inhibits the reaction [APOE gene mutant form results in increased activity of CASP3 protein]
CTD
PMID:23639522
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
G
Cat
catalase
multiple interactions
ISO
myricitrin inhibits the reaction [Hydrogen Peroxide results in decreased activity of CAT protein] myricitrin inhibits the reaction [APOE gene mutant form results in decreased activity of CAT protein]
CTD
PMID:23639522
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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Ccl2
C-C motif chemokine ligand 2
multiple interactions
ISO
myricitrin inhibits the reaction [APOE gene mutant form results in increased expression of CCL2 protein]
CTD
PMID:23639522
NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
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Col1a1
collagen type I alpha 1 chain
multiple interactions
ISO
myricitrin inhibits the reaction [Hydrogen Peroxide results in decreased expression of COL1A1 mRNA]
CTD
PMID:25130202
NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
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Crp
C-reactive protein
multiple interactions
ISO
myricitrin inhibits the reaction [APOE gene mutant form results in increased expression of CRP protein]
CTD
PMID:23639522
NCBI chr13:85,135,384...85,175,178
Ensembl chr13:85,124,977...85,175,178
G
Cyp2e1
cytochrome P450, family 2, subfamily e, polypeptide 1
multiple interactions
ISO
myricitrin inhibits the reaction [Carbon Tetrachloride results in decreased expression of CYP2E1 protein]
CTD
PMID:25656916
NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
G
Gpt
glutamic--pyruvic transaminase
multiple interactions
ISO
myricitrin inhibits the reaction [Carbon Tetrachloride results in increased activity of GPT protein]
CTD
PMID:25656916
NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
G
Gpx1
glutathione peroxidase 1
multiple interactions
ISO
myricitrin inhibits the reaction [Hydrogen Peroxide results in decreased activity of GPX1 protein]
CTD
PMID:23639522
NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024
G
Icam1
intercellular adhesion molecule 1
multiple interactions
ISO
myricitrin inhibits the reaction [APOE gene mutant form results in increased expression of ICAM1 protein]
CTD
PMID:23639522
NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
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Il6
interleukin 6
multiple interactions
ISO
myricitrin inhibits the reaction [Hydrogen Peroxide results in increased expression of IL6 protein]
CTD
PMID:25130202
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
G
Mapk1
mitogen activated protein kinase 1
multiple interactions
ISO
myricitrin inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK1 protein]
CTD
PMID:23639522
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
G
Mapk3
mitogen activated protein kinase 3
multiple interactions
ISO
myricitrin inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK3 protein]
CTD
PMID:23639522
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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Mapk8
mitogen-activated protein kinase 8
multiple interactions
ISO
myricitrin inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK8 protein]
CTD
PMID:23639522
NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
G
Nos3
nitric oxide synthase 3
multiple interactions
ISO
myricitrin inhibits the reaction [Hydrogen Peroxide results in decreased activity of NOS3 protein]
CTD
PMID:23639522
NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
G
Pcna
proliferating cell nuclear antigen
multiple interactions
ISO
myricitrin promotes the reaction [Carbon Tetrachloride results in increased expression of PCNA protein]
CTD
PMID:25656916
NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
G
Pparg
peroxisome proliferator-activated receptor gamma
multiple interactions
ISO
myricitrin inhibits the reaction [Hydrogen Peroxide results in increased expression of PPARG mRNA]
CTD
PMID:25130202
NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
G
Ptgs2
prostaglandin-endoperoxide synthase 2
multiple interactions
ISO
myricitrin inhibits the reaction [Carbon Tetrachloride results in increased expression of PTGS2 protein]
CTD
PMID:25656916
NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
G
Tgfb1
transforming growth factor, beta 1
multiple interactions
ISO
myricitrin inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 protein]
CTD
PMID:25656916
NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
G
Tnf
tumor necrosis factor
multiple interactions
ISO
myricitrin inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF protein]
CTD
PMID:25656916
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
G
Tnfsf11
TNF superfamily member 11
multiple interactions
ISO
myricitrin inhibits the reaction [Hydrogen Peroxide results in increased expression of TNFSF11 protein]
CTD
PMID:25130202
NCBI chr15:53,673,850...53,705,325
Ensembl chr15:53,673,877...53,705,445
G
Tp53
tumor protein p53
multiple interactions
ISO
myricitrin inhibits the reaction [Hydrogen Peroxide results in increased expression of TP53 protein]
CTD
PMID:23639522
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
G
Akt1
AKT serine/threonine kinase 1
multiple interactions
EXP
quercetagetin inhibits the reaction [lipoteichoic acid results in increased phosphorylation of AKT1 protein]
CTD
PMID:20685402
NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
G
Ar
androgen receptor
multiple interactions
EXP
quercetagetin inhibits the reaction [decamethrin results in increased phosphorylation of AR protein]
CTD
PMID:25299849
NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925
G
Il1b
interleukin 1 beta
multiple interactions
EXP
quercetagetin inhibits the reaction [lipoteichoic acid results in increased expression of IL1B]
CTD
PMID:20685402
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
G
Mapk1
mitogen activated protein kinase 1
multiple interactions
EXP
quercetagetin inhibits the reaction [lipoteichoic acid results in increased phosphorylation of MAPK1 protein]
CTD
PMID:20685402
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
G
Mapk3
mitogen activated protein kinase 3
multiple interactions
EXP
quercetagetin inhibits the reaction [lipoteichoic acid results in increased phosphorylation of MAPK3 protein]
CTD
PMID:20685402
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
G
Pla2g2a
phospholipase A2 group IIA
affects activity
ISO
quercetagetin affects the activity of PLA2G2A protein
CTD
PMID:8190018
NCBI chr 5:151,076,442...151,079,019
Ensembl chr 5:151,076,442...151,079,014
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