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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:acyclovir
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Accession:CHEBI:2453 term browser browse the term
Definition:An oxopurine that is guanine substituted by a (2-hydroxyethoxy)methyl substituent at position 9. Used in the treatment of viral infections.
Synonyms:exact_synonym: 2-amino-9-[(2-hydroxyethoxy)methyl]-1,9-dihydro-6H-purin-6-one
 related_synonym: Formula=C8H11N5O3;   InChI=1S/C8H11N5O3/c9-8-11-6-5(7(15)12-8)10-3-13(6)4-16-2-1-14/h3,14H,1-2,4H2,(H3,9,11,12,15);   InChIKey=MKUXAQIIEYXACX-UHFFFAOYSA-N;   SMILES=Nc1nc2n(COCCO)cnc2c(=O)[nH]1;   Zovir;   aciclovir;   aciclovirum;   acycloguanosine
 alt_id: CHEBI:40459
 xref: Beilstein:1219402;   CAS:59277-89-3;   DrugBank:DB00787;   Drug_Central:85;   HMDB:HMDB0014925;   KEGG:C06810;   KEGG:D00222;   LINCS:LSM-5459
 xref_mesh: MESH:D000212
 xref: PDBeChem:AC2;   PMID:11687127;   PMID:11994034;   PMID:24346595;   PMID:26024233;   PMID:28166217;   PMID:8308511;   Patent:DE2539963;   Patent:US4199574;   Reaxys:1219402;   Wikipedia:Acyclovir



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acyclovir term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcg2 ATP binding cassette subfamily G member 2 affects transport
multiple interactions
ISO ABCG2 protein affects the transport of Acyclovir
tryptoquivaline inhibits the reaction [ABCG2 protein affects the transport of Acyclovir]
CTD PMID:21859328 NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409
JBrowse link
G Aqp2 aquaporin 2 decreases expression EXP Acyclovir results in decreased expression of AQP2 protein CTD PMID:14675048 NCBI chr 7:130,711,433...130,716,468
Ensembl chr 7:130,711,413...130,716,468
JBrowse link
G Haao 3-hydroxyanthranilate 3,4-dioxygenase decreases activity ISO Acyclovir results in decreased activity of HAAO protein CTD PMID:17174341 NCBI chr 6:10,845,235...10,864,863
Ensembl chr 6:10,845,771...10,864,877
JBrowse link
G Ido1 indoleamine 2,3-dioxygenase 1 decreases activity ISO Acyclovir results in decreased activity of IDO1 protein CTD PMID:17174341 NCBI chr16:67,430,684...67,442,459
Ensembl chr16:67,430,578...67,442,730
JBrowse link
G Il1a interleukin 1 alpha increases expression ISO Acyclovir results in increased expression of IL1A mRNA CTD PMID:32816093 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
JBrowse link
G Il1b interleukin 1 beta increases expression ISO Acyclovir results in increased expression of IL1B mRNA CTD PMID:32816093 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il24 interleukin 24 increases expression ISO Acyclovir results in increased expression of IL24 mRNA CTD PMID:32816093 NCBI chr13:42,353,089...42,358,487
Ensembl chr13:42,353,090...42,358,487
JBrowse link
G Mr1 major histocompatibility complex, class I-related affects expression ISO Acyclovir affects the expression of MR1 mRNA CTD PMID:25811541 NCBI chr13:67,298,362...67,317,985
Ensembl chr13:67,299,585...67,317,970
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression ISO Acyclovir results in increased expression of PTGS2 mRNA CTD PMID:32816093 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Slc12a1 solute carrier family 12 member 1 decreases expression EXP Acyclovir results in decreased expression of SLC12A1 mRNA; Acyclovir results in decreased expression of SLC12A1 protein CTD PMID:14675048 NCBI chr 3:112,406,140...112,482,913
Ensembl chr 3:112,406,140...112,482,899
JBrowse link
G Slc17a1 solute carrier family 17 member 1 decreases expression EXP Acyclovir results in decreased expression of SLC17A1 mRNA; Acyclovir results in decreased expression of SLC17A1 protein CTD PMID:14675048 NCBI chr17:41,219,461...41,255,199
Ensembl chr17:41,222,049...41,253,304
JBrowse link
G Slc7a11 solute carrier family 7 member 11 increases expression ISO Acyclovir results in increased expression of SLC7A11 mRNA CTD PMID:32816093 NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536
JBrowse link
G Slpi secretory leukocyte peptidase inhibitor increases expression ISO Acyclovir results in increased expression of SLPI mRNA CTD PMID:32816093 NCBI chr 3:153,082,208...153,084,457
Ensembl chr 3:153,082,369...153,084,453
JBrowse link
G Tdo2 tryptophan 2,3-dioxygenase decreases activity EXP Acyclovir results in decreased activity of TDO2 protein CTD PMID:18665439 NCBI chr 2:167,269,581...167,287,511
Ensembl chr 2:167,269,579...167,287,511
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20056
    role 20008
      biological role 20007
        biochemical role 19640
          antimetabolite 8548
            acyclovir 14
Path 2
Term Annotations click to browse term
  CHEBI ontology 20056
    subatomic particle 20054
      composite particle 20054
        hadron 20054
          baryon 20054
            nucleon 20054
              atomic nucleus 20054
                atom 20054
                  main group element atom 19956
                    p-block element atom 19956
                      carbon group element atom 19882
                        carbon atom 19875
                          organic molecular entity 19875
                            organic molecule 19822
                              organic cyclic compound 19575
                                organic heterocyclic compound 18798
                                  organic heteropolycyclic compound 18272
                                    organic heterobicyclic compound 17159
                                      imidazopyrimidine 5633
                                        purines 5631
                                          aminopurine 4459
                                            2-aminopurines 4049
                                              guanine 4013
                                                acyclovir 14
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