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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:acyclovir
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Accession:CHEBI:2453 term browser browse the term
Definition:An oxopurine that is guanine substituted by a (2-hydroxyethoxy)methyl substituent at position 9. Used in the treatment of viral infections.
Synonyms:exact_synonym: 2-amino-9-[(2-hydroxyethoxy)methyl]-1,9-dihydro-6H-purin-6-one
 related_synonym: Formula=C8H11N5O3;   InChI=1S/C8H11N5O3/c9-8-11-6-5(7(15)12-8)10-3-13(6)4-16-2-1-14/h3,14H,1-2,4H2,(H3,9,11,12,15);   InChIKey=MKUXAQIIEYXACX-UHFFFAOYSA-N;   SMILES=Nc1nc2n(COCCO)cnc2c(=O)[nH]1;   Zovir;   aciclovir;   aciclovirum;   acycloguanosine
 alt_id: CHEBI:40459
 xref: Beilstein:1219402;   CAS:59277-89-3;   DrugBank:DB00787;   Drug_Central:85;   HMDB:HMDB0014925;   KEGG:C06810;   KEGG:D00222;   LINCS:LSM-5459
 xref_mesh: MESH:D000212
 xref: PDBeChem:AC2;   PMID:11687127;   PMID:11994034;   PMID:24346595;   PMID:26024233;   PMID:28166217;   PMID:8308511;   Patent:DE2539963;   Patent:US4199574;   Reaxys:1219402;   Wikipedia:Acyclovir


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acyclovir term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcg2 ATP binding cassette subfamily G member 2 affects transport
multiple interactions
ISO ABCG2 protein affects the transport of Acyclovir
tryptoquivaline inhibits the reaction [ABCG2 protein affects the transport of Acyclovir]
CTD PMID:21859328 NCBI chr 4:88,765,441...88,890,268
Ensembl chr 4:88,832,178...88,890,621
JBrowse link
G Aqp2 aquaporin 2 decreases expression EXP Acyclovir results in decreased expression of AQP2 protein CTD PMID:14675048 NCBI chr 7:141,237,802...141,242,837
Ensembl chr 7:141,237,768...141,245,165
JBrowse link
G Haao 3-hydroxyanthranilate 3,4-dioxygenase decreases activity ISO Acyclovir results in decreased activity of HAAO protein CTD PMID:17174341 NCBI chr 6:7,045,145...7,059,227
Ensembl chr 6:7,045,152...7,058,314
JBrowse link
G Ido1 indoleamine 2,3-dioxygenase 1 decreases activity ISO Acyclovir results in decreased activity of IDO1 protein CTD PMID:17174341 NCBI chr16:72,216,326...72,228,098
Ensembl chr16:72,216,326...72,228,098
JBrowse link
G Il1a interleukin 1 alpha increases expression ISO Acyclovir results in increased expression of IL1A mRNA CTD PMID:32816093 NCBI chr 3:121,824,712...121,836,122
Ensembl chr 3:121,825,412...121,836,086
JBrowse link
G Il1b interleukin 1 beta increases expression ISO Acyclovir results in increased expression of IL1B mRNA CTD PMID:32816093 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il24 interleukin 24 increases expression ISO Acyclovir results in increased expression of IL24 mRNA CTD PMID:32816093 NCBI chr13:47,618,451...47,623,849
Ensembl chr13:47,618,452...47,623,849
JBrowse link
G Mr1 major histocompatibility complex, class I-related affects expression ISO Acyclovir affects the expression of MR1 mRNA CTD PMID:25811541 NCBI chr13:72,771,992...72,789,861
Ensembl chr13:72,771,984...72,789,841
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression ISO Acyclovir results in increased expression of PTGS2 mRNA CTD PMID:32816093 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Slc12a1 solute carrier family 12 member 1 decreases expression EXP Acyclovir results in decreased expression of SLC12A1 mRNA; Acyclovir results in decreased expression of SLC12A1 protein CTD PMID:14675048 NCBI chr 3:117,421,531...117,498,372
Ensembl chr 3:117,421,604...117,498,367
JBrowse link
G Slc17a1 solute carrier family 17 member 1 decreases expression EXP Acyclovir results in decreased expression of SLC17A1 mRNA; Acyclovir results in decreased expression of SLC17A1 protein CTD PMID:14675048 NCBI chr17:43,473,048...43,504,645 JBrowse link
G Slc7a11 solute carrier family 7 member 11 increases expression ISO Acyclovir results in increased expression of SLC7A11 mRNA CTD PMID:32816093 NCBI chr 2:139,453,774...139,528,479
Ensembl chr 2:139,453,774...139,528,162
JBrowse link
G Slpi secretory leukocyte peptidase inhibitor increases expression ISO Acyclovir results in increased expression of SLPI mRNA CTD PMID:32816093 NCBI chr 3:160,799,979...160,802,228
Ensembl chr 3:160,799,981...160,802,433
JBrowse link
G Tdo2 tryptophan 2,3-dioxygenase decreases activity EXP Acyclovir results in decreased activity of TDO2 protein CTD PMID:18665439 NCBI chr 2:180,897,059...180,914,919
Ensembl chr 2:180,897,011...180,914,940
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19773
    role 19719
      biological role 19719
        biochemical role 19312
          antimetabolite 8514
            acyclovir 14
Path 2
Term Annotations click to browse term
  CHEBI ontology 19773
    subatomic particle 19772
      composite particle 19772
        hadron 19772
          baryon 19772
            nucleon 19772
              atomic nucleus 19772
                atom 19772
                  main group element atom 19662
                    p-block element atom 19662
                      carbon group element atom 19579
                        carbon atom 19569
                          organic molecular entity 19569
                            organic molecule 19502
                              organic cyclic compound 19329
                                organic heterocyclic compound 18544
                                  organic heteropolycyclic compound 18035
                                    organic heterobicyclic compound 16783
                                      imidazopyrimidine 5609
                                        purines 5607
                                          aminopurine 4425
                                            2-aminopurines 4033
                                              guanine 3997
                                                acyclovir 14
paths to the root