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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:guanosines
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Accession:CHEBI:24458 term browser browse the term
Definition:Any purine ribonucleoside that is a derivative of guanosine.


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2'-deoxyguanosine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 multiple interactions ISO [9-deaza-9-(3-thienylmethyl)guanine co-treated with Deoxyguanosine] results in increased activity of CASP3 protein; Deoxycytidine inhibits the reaction [[9-deaza-9-(3-thienylmethyl)guanine co-treated with Deoxyguanosine] results in increased activity of CASP3 protein] CTD PMID:9297556 PMID:9403342 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO CYP1A1 protein promotes the reaction [Aflatoxin B1 binds to Deoxyguanosine] CTD PMID:21907773 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions ISO CYP1A2 protein promotes the reaction [Aflatoxin B1 binds to Deoxyguanosine]; CYP1A2 protein promotes the reaction [Estrone binds to Deoxyguanosine] CTD PMID:21907773 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 multiple interactions ISO CYP1B1 protein promotes the reaction [Aflatoxin B1 binds to Deoxyguanosine] CTD PMID:21907773 NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722
JBrowse link
G Cyp3a62 cytochrome P450, family 3, subfamily a, polypeptide 62 multiple interactions ISO CYP3A4 protein promotes the reaction [Aflatoxin B1 binds to Deoxyguanosine]; CYP3A4 protein promotes the reaction [Estrone binds to Deoxyguanosine] CTD PMID:21907773 NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397
JBrowse link
G Mgmt O-6-methylguanine-DNA methyltransferase decreases activity ISO Deoxyguanosine analog results in decreased activity of MGMT protein CTD PMID:17880193 NCBI chr 1:209,237,255...209,464,189
Ensembl chr 1:209,237,233...209,464,190
JBrowse link
8-chloro-2'-deoxyguanosine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl5 C-C motif chemokine ligand 5 decreases expression ISO 8-chloro-2'-deoxyguanosine results in decreased expression of CCL5 mRNA CTD PMID:31066272 NCBI chr10:70,739,764...70,744,303
Ensembl chr10:70,739,800...70,744,315
JBrowse link
G Il18 interleukin 18 increases expression ISO 8-chloro-2'-deoxyguanosine results in increased expression of IL18 mRNA CTD PMID:31066272 NCBI chr 8:55,009,666...55,016,286
Ensembl chr 8:54,993,859...55,016,299
JBrowse link
G Il1b interleukin 1 beta increases expression
increases secretion
ISO 8-chloro-2'-deoxyguanosine results in increased expression of IL1B mRNA
8-chloro-2'-deoxyguanosine results in increased secretion of IL1B protein
CTD PMID:31066272 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
8-hydroxy-2'-deoxyguanosine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen increases abundance ISO AGT protein modified form results in increased abundance of 8-Hydroxy-2'-Deoxyguanosine CTD PMID:30354818 NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433
JBrowse link
G Apex1 apurinic/apyrimidinic endodeoxyribonuclease 1 affects abundance ISO APEX1 gene SNP affects the abundance of 8-Hydroxy-2'-Deoxyguanosine CTD PMID:19896490 NCBI chr15:27,849,943...27,852,083
Ensembl chr15:27,849,979...27,852,082
JBrowse link
G Brca1 BRCA1, DNA repair associated multiple interactions ISO [BRCA1 gene mutant form results in increased susceptibility to Ethanol] which results in increased abundance of 8-Hydroxy-2'-Deoxyguanosine CTD PMID:26629949 NCBI chr10:89,394,821...89,455,093
Ensembl chr10:89,394,803...89,454,681
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 multiple interactions ISO [Eugenol co-treated with Copper co-treated with CYP2D6 protein] results in increased abundance of 8-Hydroxy-2'-Deoxyguanosine CTD PMID:15576237 NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436
JBrowse link
G Dnmt1 DNA methyltransferase 1 affects abundance ISO DNMT1 gene SNP affects the abundance of 8-Hydroxy-2'-Deoxyguanosine CTD PMID:19896490 NCBI chr 8:21,922,515...21,968,495
Ensembl chr 8:21,922,515...21,968,495
JBrowse link
G Dnmt3b DNA methyltransferase 3 beta affects abundance ISO DNMT3B gene SNP affects the abundance of 8-Hydroxy-2'-Deoxyguanosine CTD PMID:19896490 NCBI chr 3:149,131,541...149,170,061
Ensembl chr 3:149,131,785...149,208,786
JBrowse link
G Glrx glutaredoxin affects abundance ISO GLRX gene SNP affects the abundance of 8-Hydroxy-2'-Deoxyguanosine CTD PMID:19896490 NCBI chr 2:2,606,032...2,615,944
Ensembl chr 2:2,605,996...2,615,944
JBrowse link
G Hras HRas proto-oncogene, GTPase multiple interactions
increases abundance
ISO PRDX1 protein inhibits the reaction [HRAS protein mutant form results in increased abundance of 8-Hydroxy-2'-Deoxyguanosine] CTD PMID:27517622 NCBI chr 1:214,178,404...214,181,841
Ensembl chr 1:214,178,407...214,181,686
JBrowse link
G Ogg1 8-oxoguanine DNA glycosylase multiple interactions
increases cleavage
ISO thymidine glycol inhibits the reaction [OGG1 protein results in increased cleavage of 8-Hydroxy-2'-Deoxyguanosine]; thymidine glycol promotes the reaction [OGG1 protein results in increased cleavage of 8-Hydroxy-2'-Deoxyguanosine] CTD PMID:19193190 NCBI chr 4:145,282,828...145,289,367
Ensembl chr 4:145,282,797...145,289,326
JBrowse link
G Por cytochrome p450 oxidoreductase multiple interactions EXP [Nitrofurazone co-treated with POR protein co-treated with Copper] results in increased abundance of 8-Hydroxy-2'-Deoxyguanosine CTD PMID:15488632 NCBI chr12:23,998,411...24,017,063
Ensembl chr12:23,998,411...24,046,814
JBrowse link
G Prdx1 peroxiredoxin 1 multiple interactions ISO PRDX1 protein inhibits the reaction [HRAS protein mutant form results in increased abundance of 8-Hydroxy-2'-Deoxyguanosine] CTD PMID:27517622 NCBI chr 5:135,536,413...135,551,986
Ensembl chr 5:135,536,413...135,551,990
JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 multiple interactions ISO [[Arachidonic Acid results in increased activity of PTGS1 protein] which results in increased susceptibility to 3,4-Methylenedioxyamphetamine] which results in increased abundance of 8-Hydroxy-2'-Deoxyguanosine; [[Arachidonic Acid results in increased activity of PTGS1 protein] which results in increased susceptibility to Methamphetamine] which results in increased abundance of 8-Hydroxy-2'-Deoxyguanosine CTD PMID:21163909 NCBI chr 3:15,560,685...15,582,339
Ensembl chr 3:15,560,712...15,582,344
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO [[Arachidonic Acid results in increased activity of PTGS2 protein] which results in increased susceptibility to 3,4-Methylenedioxyamphetamine] which results in increased abundance of 8-Hydroxy-2'-Deoxyguanosine; [[Arachidonic Acid results in increased activity of PTGS2 protein] which results in increased susceptibility to Methamphetamine] which results in increased abundance of 8-Hydroxy-2'-Deoxyguanosine CTD PMID:21163909 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Txnrd1 thioredoxin reductase 1 affects abundance ISO TXNRD1 gene SNP affects the abundance of 8-Hydroxy-2'-Deoxyguanosine CTD PMID:19896490 NCBI chr 7:26,946,124...26,984,400
Ensembl chr 7:26,946,125...26,984,400
JBrowse link
G Txnrd2 thioredoxin reductase 2 affects abundance ISO TXNRD2 gene SNP affects the abundance of 8-Hydroxy-2'-Deoxyguanosine CTD PMID:19896490 NCBI chr11:86,667,994...86,716,063
Ensembl chr11:86,667,997...86,716,254
JBrowse link
guanosine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 multiple interactions EXP Guanosine inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased activity of CASP3 protein] CTD PMID:25174304 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Eif4e eukaryotic translation initiation factor 4E affects binding
multiple interactions
ISO Guanosine analog binds to EIF4E protein
Guanosine analog inhibits the reaction [7-methylguanosine 5'-diphosphate analog binds to EIF4E protein]; Guanosine analog inhibits the reaction [RNA Caps binds to EIF4E protein]
CTD PMID:27592390 NCBI chr 2:243,819,616...243,853,987
Ensembl chr 2:243,820,661...243,852,631
JBrowse link
G H2ax H2A.X variant histone multiple interactions ISO Guanosine inhibits the reaction [Cesium-137 results in increased expression of and affects the localization of H2AX protein modified form] CTD PMID:32941855 NCBI chr 8:48,665,652...48,666,981
Ensembl chr 8:48,665,652...48,666,981
JBrowse link
G Impdh2 inosine monophosphate dehydrogenase 2 decreases expression EXP Guanosine results in decreased expression of IMPDH2 mRNA CTD PMID:11145582 NCBI chr 8:117,346,983...117,351,619
Ensembl chr 8:117,347,029...117,351,610
JBrowse link
G Kras KRAS proto-oncogene, GTPase multiple interactions ISO Guanosine inhibits the reaction [tiazofurin results in decreased expression of KRAS] CTD PMID:9381980 NCBI chr 4:179,482,562...179,515,483
Ensembl chr 4:179,486,105...179,515,558
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO Guanosine results in increased phosphorylation of and results in increased activity of MAPK1 protein CTD PMID:18456249 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO Guanosine results in increased phosphorylation of and results in increased activity of MAPK3 protein CTD PMID:18456249 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions ISO Guanosine inhibits the reaction [tiazofurin results in decreased expression of MYC] CTD PMID:9381980 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
JBrowse link
G Slc29a1 solute carrier family 29 member 1 multiple interactions ISO
EXP
Guanosine inhibits the reaction [SLC29A1 protein results in increased uptake of Uridine] CTD PMID:9353301 PMID:11085929 NCBI chr 9:17,784,468...17,799,008
Ensembl chr 9:17,784,468...17,799,005
JBrowse link
G Slc29a2 solute carrier family 29 member 2 multiple interactions ISO Guanosine inhibits the reaction [SLC29A2 protein results in increased uptake of Uridine] CTD PMID:11085929 NCBI chr 1:220,306,622...220,314,631
Ensembl chr 1:220,400,855...220,407,189
Ensembl chr 1:220,400,855...220,407,189
JBrowse link
G Slc29a3 solute carrier family 29 member 3 affects transport ISO SLC29A3 protein affects the transport of Guanosine CTD PMID:19164483 NCBI chr20:30,289,527...30,327,343
Ensembl chr20:30,287,424...30,327,361
JBrowse link
G Tp53bp1 tumor protein p53 binding protein 1 multiple interactions ISO Guanosine inhibits the reaction [Cesium-137 results in increased expression of and affects the localization of TP53BP1 protein] CTD PMID:32941855 NCBI chr 3:113,160,030...113,259,701
Ensembl chr 3:113,160,000...113,231,790
JBrowse link
G Upp1 uridine phosphorylase 1 increases metabolic processing ISO UPP1 protein results in increased metabolism of Guanosine CTD PMID:15772079 NCBI chr14:89,314,234...89,334,060
Ensembl chr14:89,314,176...89,334,276
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19770
    role 19720
      biological role 19720
        biochemical role 19310
          metabolite 19292
            eukaryotic metabolite 18963
              algal metabolite 13646
                guanine 3991
                  guanosines 36
                    3'-deoxyguanosine 0
                    8-bromo-2'-deoxyguanosine 0
                    8-chloro-2'-deoxyguanosine 3
                    8-hydroxy-2'-deoxyguanosine 15
                    L-lactyl-2-diphospho-5'-guanosine 0
                    N(2)-carboxyethylguanosine + 0
                    N(2)-carboxymethylguanosine 0
                    N-(deoxyguanosin-8-yl)-2-acetylaminofluorene 0
                    N-(deoxyguanosin-8-yl)-2-aminofluorene 0
                    guanosine + 18
                    methylguanosine + 0
                    nitroguanosine + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19770
    subatomic particle 19768
      composite particle 19768
        hadron 19768
          baryon 19768
            nucleon 19768
              atomic nucleus 19768
                atom 19768
                  main group element atom 19662
                    p-block element atom 19662
                      carbon group element atom 19580
                        carbon atom 19571
                          organic molecular entity 19571
                            heteroorganic entity 19206
                              organochalcogen compound 18951
                                organooxygen compound 18877
                                  carbohydrates and carbohydrate derivatives 12259
                                    carbohydrate 12259
                                      carbohydrate derivative 11889
                                        glycosyl compound 10958
                                          N-glycosyl compound 5480
                                            nucleoside 5342
                                              ribonucleoside 667
                                                purine ribonucleoside 560
                                                  guanosines 36
                                                    3'-deoxyguanosine 0
                                                    8-bromo-2'-deoxyguanosine 0
                                                    8-chloro-2'-deoxyguanosine 3
                                                    8-hydroxy-2'-deoxyguanosine 15
                                                    L-lactyl-2-diphospho-5'-guanosine 0
                                                    N(2)-carboxyethylguanosine + 0
                                                    N(2)-carboxymethylguanosine 0
                                                    N-(deoxyguanosin-8-yl)-2-acetylaminofluorene 0
                                                    N-(deoxyguanosin-8-yl)-2-aminofluorene 0
                                                    guanosine + 18
                                                    methylguanosine + 0
                                                    nitroguanosine + 0
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