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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:dehydrocostus lactone
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Accession:CHEBI:244418 term browser browse the term
Definition:An organic heterotricyclic compound and guaianolide sesquiterpene lactone that is acrylic acid which is substituted at position 2 by a 4-hydroxy-3,8-bis(methylene)decahydoazulen-5-yl group and in which the hydroxy group and the carboxy group have undergone formal condensation to afford the corresponding gamma-lactone.
Synonyms:exact_synonym: (3aR,6aS,9aS,9bR)-3,6,9-tris(methylene)octahydroazuleno[4,5-b]furan-2,8(3H,4H)-dione;   (3aR,6aS,9aS,9bR)-3,6,9-tris(methylidene)octahydroazuleno[4,5-b]furan-2,8(3H,4H)-dione
 related_synonym: (3aS,6aR,9aR,9bS)-decahydro-3,6,9-tris(methylene)azuleno[4,5-b]furan-2(3H)-one;   Formula=C15H18O2;   InChI=1S/C15H18O2/c1-8-4-7-12-10(3)15(16)17-14(12)13-9(2)5-6-11(8)13/h11-14H,1-7H2/t11-,12-,13-,14-/m0/s1;   InChIKey=NETSQGRTUNRXEO-XUXIUFHCSA-N;   SMILES=[H][C@@]12CCC(=C)[C@]1([H])[C@H]1OC(=O)C(=C)[C@@H]1CCC2=C;   dehydrocostuslactone
 alt_id: CHEBI:4359;   CHEBI:467325
 xref: Beilstein:4733740;   CAS:477-43-0;   KEGG:C09387;   KNApSAcK:C00003245
 xref_mesh: MESH:C083030
 xref: PMID:10193198;   PMID:12419922;   PMID:14192430;   PMID:15209353;   PMID:15881118;   PMID:17391667;   PMID:19148545;   PMID:19188481;   PMID:19457452;   PMID:19700217;   PMID:21353686;   PMID:21472220;   PMID:21596031;   PMID:22359572;   PMID:23047249;   PMID:6476889;   PMID:8541643;   PMID:9784148;   PMID:9917276;   Patent:CN102058579;   Reaxys:4733740



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dehydrocostus lactone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hmox1 heme oxygenase 1 increases expression ISO dehydrocostus lactone results in increased expression of HMOX1 protein CTD PMID:23942037 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Il6 interleukin 6 multiple interactions ISO dehydrocostus lactone inhibits the reaction [Hydrogen Peroxide results in increased secretion of IL6 protein] CTD PMID:19457452 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO dehydrocostus lactone inhibits the reaction [Ethanol results in increased expression of NOS2 protein] CTD PMID:26970604 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO dehydrocostus lactone inhibits the reaction [Ethanol results in increased expression of PTGS2 protein] CTD PMID:26970604 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO dehydrocostus lactone inhibits the reaction [Ethanol results in increased expression of TNF protein] CTD PMID:26970604 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tnfsf11 TNF superfamily member 11 multiple interactions ISO dehydrocostus lactone inhibits the reaction [Hydrogen Peroxide results in increased secretion of TNFSF11 protein] CTD PMID:19457452 NCBI chr15:53,673,850...53,705,325
Ensembl chr15:53,673,877...53,705,445
JBrowse link

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Path 1
Term Annotations click to browse term
  CHEBI ontology 19911
    role 19887
      biological role 19885
        biochemical role 19581
          metabolite 19567
            dehydrocostus lactone 6
Path 2
Term Annotations click to browse term
  CHEBI ontology 19911
    subatomic particle 19909
      composite particle 19909
        hadron 19909
          baryon 19909
            nucleon 19909
              atomic nucleus 19909
                atom 19909
                  main group element atom 19859
                    p-block element atom 19859
                      carbon group element atom 19803
                        carbon atom 19799
                          organic molecular entity 19799
                            organic group 18986
                              organic divalent group 18961
                                organodiyl group 18961
                                  carbonyl group 18917
                                    carbonyl compound 18917
                                      carboxylic ester 16333
                                        lactone 11588
                                          terpene lactone 2174
                                            sesquiterpene lactone 2028
                                              dehydrocostus lactone 6
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