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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:glycosphingolipid
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Accession:CHEBI:24402 term browser browse the term
Definition:A glycosphingolipid is a glycolipid that is a carbohydrate-containing derivative of a sphingoid or ceramide. It is understood that the carbohydrate residue is attached by a glycosidic linkage to O-1 of the sphingoid.
Synonyms:related_synonym: glycosphingolipids
 alt_id: CHEBI:5498
 xref: PMID:18845618;   PMID:19303901;   PMID:26954668;   PMID:26976737;   PMID:27253729;   PMID:27325407;   Wikipedia:Glycosphingolipid


show annotations for term's descendants           Sort by:
1-O-(alpha-D-galactosyl)-N-hexacosanoylphytosphingosine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cxcl10 C-X-C motif chemokine ligand 10 increases expression ISO KRN 7000 results in increased expression of CXCL10 protein CTD PMID:15867097 NCBI chr 5:92,494,497...92,496,748
Ensembl chr 5:92,494,497...92,496,748 		JBrowse link
G Il12b interleukin 12b increases expression ISO KRN 7000 results in increased expression of IL12B protein CTD PMID:15867097 NCBI chr11:44,290,890...44,305,504
Ensembl chr11:44,290,890...44,304,860 		JBrowse link
alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosylceramide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP-binding cassette, sub-family B member 1A increases chemical synthesis
multiple interactions		 ISO ABCB1 protein results in increased chemical synthesis of globotriaosylceramide
Cyclosporine inhibits the reaction [ABCB1 protein results in increased chemical synthesis of globotriaosylceramide]; Ketoconazole inhibits the reaction [ABCB1 protein results in increased chemical synthesis of globotriaosylceramide]		 CTD PMID:14662772 NCBI chr 5:8,617,091...8,798,575
Ensembl chr 5:8,710,077...8,798,575 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Curcumin inhibits the reaction [IL1B protein promotes the reaction [Shiga Toxin binds to globotriaosylceramide]]; IL1B protein promotes the reaction [Shiga Toxin binds to globotriaosylceramide]; TNF protein promotes the reaction [IL1B protein promotes the reaction [Shiga Toxin binds to globotriaosylceramide]] CTD PMID:16819191 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Curcumin inhibits the reaction [TNF protein promotes the reaction [Shiga Toxin binds to globotriaosylceramide]]; TNF protein promotes the reaction [IL1B protein promotes the reaction [Shiga Toxin binds to globotriaosylceramide]]; TNF protein promotes the reaction [Shiga Toxin binds to globotriaosylceramide] CTD PMID:16819191 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
alpha-galactosylceramide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gata3 GATA binding protein 3 multiple interactions EXP [Ovalbumin co-treated with alpha-galactosylceramide] results in decreased expression of GATA3 mRNA CTD PMID:30803854 NCBI chr 2:9,861,889...9,894,845
Ensembl chr 2:9,861,889...9,894,845 		JBrowse link
G Gpt glutamic pyruvic transaminase, soluble multiple interactions EXP [Floxacillin co-treated with alpha-galactosylceramide] results in increased expression of GPT protein CTD PMID:30993380 NCBI chr15:76,580,926...76,583,875
Ensembl chr15:76,579,916...76,583,886 		JBrowse link
G Ifng interferon gamma multiple interactions
increases secretion		 EXP [Alcohols co-treated with alpha-galactosylceramide] results in increased expression of IFNG protein; [Ovalbumin co-treated with alpha-galactosylceramide] results in increased secretion of IFNG protein
alpha-galactosylceramide results in increased secretion of IFNG protein		 CTD PMID:12482940 PMID:25499027 PMID:30803854 NCBI chr10:118,276,951...118,281,799
Ensembl chr10:118,276,951...118,281,797 		JBrowse link
G Il10 interleukin 10 multiple interactions EXP [Ovalbumin co-treated with alpha-galactosylceramide] results in decreased secretion of IL10 protein CTD PMID:30803854 NCBI chr 1:130,947,459...130,952,707
Ensembl chr 1:130,947,582...130,952,711 		JBrowse link
G Il13 interleukin 13 multiple interactions EXP [Ovalbumin co-treated with alpha-galactosylceramide] results in decreased secretion of IL13 protein CTD PMID:30803854 NCBI chr11:53,522,150...53,525,529
Ensembl chr11:53,522,151...53,525,529 		JBrowse link
G Il17a interleukin 17A multiple interactions EXP [Ovalbumin co-treated with alpha-galactosylceramide] results in decreased secretion of IL17A protein CTD PMID:30803854 NCBI chr 1:20,801,129...20,804,720
Ensembl chr 1:20,801,129...20,804,720 		JBrowse link
G Il4 interleukin 4 increases secretion
multiple interactions		 EXP alpha-galactosylceramide results in increased secretion of IL4 protein
[Ovalbumin co-treated with alpha-galactosylceramide] results in decreased secretion of IL4 protein		 CTD PMID:12482940 PMID:30803854 NCBI chr11:53,503,287...53,509,492
Ensembl chr11:53,493,809...53,509,496 		JBrowse link
G Il5 interleukin 5 multiple interactions EXP [Ovalbumin co-treated with alpha-galactosylceramide] results in decreased secretion of IL5 protein CTD PMID:30803854 NCBI chr11:53,611,621...53,615,930
Ensembl chr11:53,611,621...53,615,933 		JBrowse link
G Klrb1c killer cell lectin-like receptor subfamily B member 1C decreases expression EXP alpha-galactosylceramide results in decreased expression of KLRB1C protein CTD PMID:30993380 NCBI chr 6:128,755,448...128,765,514
Ensembl chr 6:128,755,448...128,766,178 		JBrowse link
G Rorc RAR-related orphan receptor gamma multiple interactions EXP [Ovalbumin co-treated with alpha-galactosylceramide] results in decreased expression of RORC mRNA alternative form CTD PMID:30803854 NCBI chr 3:94,280,106...94,305,583
Ensembl chr 3:94,280,101...94,305,583 		JBrowse link
G Tbx21 T-box 21 multiple interactions EXP [Ovalbumin co-treated with alpha-galactosylceramide] results in increased expression of TBX21 mRNA CTD PMID:30803854 NCBI chr11:96,988,833...97,006,157
Ensembl chr11:96,988,897...97,006,157 		JBrowse link
beta-D-Gal-(1->3)-beta-D-GalNAc-(1->4)-[alpha-Neu5Ac-(2->8)-alpha-Neu5Ac-(2->3)]-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1')-Cer term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nos2 nitric oxide synthase 2, inducible multiple interactions EXP ganglioside, GD1b analog inhibits the reaction [[lipopolysaccharide, E. coli O26-B6 results in increased activity of NOS2 protein] which results in increased secretion of Nitrites]; ganglioside, GD1b inhibits the reaction [[lipopolysaccharide, E. coli O26-B6 results in increased activity of NOS2 protein] which results in increased secretion of Nitrites] CTD PMID:31202640 NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080 		JBrowse link
ganglioside GM1 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd14 CD14 antigen multiple interactions ISO CD14 protein affects the reaction [G(M1) Ganglioside results in increased secretion of Nitric Oxide] CTD PMID:16651628 NCBI chr18:36,858,117...36,859,868
Ensembl chr18:36,858,120...36,859,851 		JBrowse link
G Cdkn1a cyclin dependent kinase inhibitor 1A increases expression ISO G(M1) Ganglioside results in increased expression of CDKN1A protein CTD PMID:15654767 NCBI chr17:29,309,953...29,319,696
Ensembl chr17:29,309,950...29,319,701 		JBrowse link
G Cdkn1b cyclin dependent kinase inhibitor 1B decreases expression ISO G(M1) Ganglioside results in decreased expression of CDKN1B protein CTD PMID:15654767 NCBI chr 6:134,897,364...134,902,488
Ensembl chr 6:134,897,364...134,902,476 		JBrowse link
G Npc1 NPC intracellular cholesterol transporter 1 affects localization EXP NPC1 affects the localization of G(M1) Ganglioside CTD PMID:12183525 NCBI chr18:12,322,751...12,369,851
Ensembl chr18:12,322,749...12,369,457 		JBrowse link
G Ntrk1 neurotrophic tyrosine kinase, receptor, type 1 multiple interactions ISO G(M1) Ganglioside inhibits the reaction [Methylmercury Compounds results in decreased phosphorylation of NTRK1 protein]; G(M1) Ganglioside inhibits the reaction [staurosporine aglycone results in decreased phosphorylation of NTRK1 protein] CTD PMID:25545984 NCBI chr 3:87,685,551...87,702,549
Ensembl chr 3:87,685,551...87,702,469 		JBrowse link
G Pld1 phospholipase D1 multiple interactions ISO PLD1 protein affects the reaction [dinitrophenyl-bovine serum albumin affects the localization of G(M1) Ganglioside] CTD PMID:19794068 NCBI chr 3:27,992,636...28,187,388
Ensembl chr 3:27,992,844...28,187,511 		JBrowse link
G Pld2 phospholipase D2 multiple interactions ISO PLD2 protein affects the reaction [dinitrophenyl-bovine serum albumin affects the localization of G(M1) Ganglioside] CTD PMID:19794068 NCBI chr11:70,430,318...70,448,936
Ensembl chr11:70,430,890...70,448,936 		JBrowse link
G Slc18a2 solute carrier family 18 (vesicular monoamine), member 2 increases expression ISO G(M1) Ganglioside results in increased expression of SLC18A2 mRNA CTD PMID:14552908 NCBI chr19:59,249,310...59,284,444
Ensembl chr19:59,249,328...59,284,444 		JBrowse link
G Slc6a3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 increases expression ISO G(M1) Ganglioside results in increased expression of SLC6A3 mRNA CTD PMID:14552908 NCBI chr13:73,684,270...73,726,791
Ensembl chr13:73,684,866...73,726,791 		JBrowse link
G Th tyrosine hydroxylase increases activity ISO G(M1) Ganglioside results in increased activity of TH protein CTD PMID:14552908 NCBI chr 7:142,446,516...142,453,732
Ensembl chr 7:142,446,489...142,484,865 		JBrowse link
G Tlr4 toll-like receptor 4 decreases expression ISO G(M1) Ganglioside results in decreased expression of TLR4 protein CTD PMID:16651628 NCBI chr 4:66,745,788...66,765,338
Ensembl chr 4:66,745,821...66,848,521 		JBrowse link
phytosphingosine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aifm1 apoptosis-inducing factor, mitochondrion-associated 1 affects localization
multiple interactions		 ISO phytosphingosine affects the localization of AIFM1 protein
3,4-dihydro-5-(4-(1-piperidinyl)butoxy)-1(2H)-isoquinolinone inhibits the reaction [phytosphingosine affects the localization of AIFM1 protein]		 CTD PMID:15486061 NCBI chr  X:47,563,821...47,602,440
Ensembl chr  X:47,563,821...47,602,440 		JBrowse link
G Bax BCL2-associated X protein multiple interactions
affects localization
increases expression		 ISO 3,4-dihydro-5-(4-(1-piperidinyl)butoxy)-1(2H)-isoquinolinone inhibits the reaction [[arsenic trioxide co-treated with phytosphingosine] results in increased localization of BAX protein]; [arsenic trioxide co-treated with phytosphingosine] results in increased localization of BAX protein; Acetylcysteine inhibits the reaction [[arsenic trioxide co-treated with phytosphingosine] results in increased localization of BAX protein]; SB 203580 inhibits the reaction [[arsenic trioxide co-treated with phytosphingosine] results in increased localization of BAX protein]
phytosphingosine affects the localization of BAX protein
phytosphingosine results in increased expression of BAX protein		 CTD PMID:15486061 PMID:17237268 PMID:36334778 PMID:37956922 NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322 		JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 increases expression ISO phytosphingosine results in increased expression of BCL2 protein CTD PMID:36334778 NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases expression		 ISO 3,4-dihydro-5-(4-(1-piperidinyl)butoxy)-1(2H)-isoquinolinone inhibits the reaction [[Arsenic Trioxide co-treated with phytosphingosine] results in increased activity of CASP3 protein]; [Arsenic Trioxide co-treated with phytosphingosine] results in increased activity of CASP3 protein; phytosphingosine results in increased expression of and results in increased cleavage of CASP3 protein; SB 203580 inhibits the reaction [[Arsenic Trioxide co-treated with phytosphingosine] results in increased activity of CASP3 protein]
phytosphingosine results in increased expression of CASP3 protein		 CTD PMID:17237268 PMID:36334778 PMID:37956922 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724 		JBrowse link
G Casp9 caspase 9 multiple interactions
increases expression		 ISO 3,4-dihydro-5-(4-(1-piperidinyl)butoxy)-1(2H)-isoquinolinone inhibits the reaction [[arsenic trioxide co-treated with phytosphingosine] results in increased activity of CASP9 protein]; [arsenic trioxide co-treated with phytosphingosine] results in increased activity of CASP9 protein; SB 203580 inhibits the reaction [[arsenic trioxide co-treated with phytosphingosine] results in increased activity of CASP9 protein]
phytosphingosine results in increased expression of CASP9 protein		 CTD PMID:17237268 PMID:37956922 NCBI chr 4:141,520,923...141,543,289
Ensembl chr 4:141,520,923...141,543,287 		JBrowse link
G Ccnb1 cyclin B1 decreases expression ISO phytosphingosine results in decreased expression of CCNB1 protein CTD PMID:37956922 NCBI chr13:100,915,247...100,922,994
Ensembl chr13:100,915,158...100,923,078 		JBrowse link
G Cdk1 cyclin dependent kinase 1 decreases expression ISO phytosphingosine results in decreased expression of CDK1 protein CTD PMID:37956922 NCBI chr10:69,170,976...69,188,742
Ensembl chr10:69,170,976...69,188,768 		JBrowse link
G Cycs cytochrome c, somatic increases expression ISO phytosphingosine results in increased expression of CYCS protein CTD PMID:36334778 NCBI chr 6:50,539,543...50,543,549
Ensembl chr 6:50,539,543...50,543,518 		JBrowse link
G Mapk1 mitogen-activated protein kinase 1 multiple interactions ISO [arsenic trioxide co-treated with phytosphingosine] results in decreased phosphorylation of MAPK1 protein CTD PMID:17237268 NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317 		JBrowse link
G Mapk14 mitogen-activated protein kinase 14 multiple interactions ISO 3,4-dihydro-5-(4-(1-piperidinyl)butoxy)-1(2H)-isoquinolinone inhibits the reaction [[arsenic trioxide co-treated with phytosphingosine] results in increased phosphorylation of MAPK14 protein]; [arsenic trioxide co-treated with phytosphingosine] results in increased phosphorylation of MAPK14 protein; Acetylcysteine inhibits the reaction [[arsenic trioxide co-treated with phytosphingosine] results in increased phosphorylation of MAPK14 protein] CTD PMID:17237268 NCBI chr17:28,910,316...28,967,379
Ensembl chr17:28,910,303...28,967,380 		JBrowse link
G Mapk3 mitogen-activated protein kinase 3 multiple interactions ISO [arsenic trioxide co-treated with phytosphingosine] results in decreased phosphorylation of MAPK3 protein CTD PMID:17237268 NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase family, member 1 multiple interactions
increases cleavage
increases activity		 ISO 3,4-dihydro-5-(4-(1-piperidinyl)butoxy)-1(2H)-isoquinolinone inhibits the reaction [[arsenic trioxide co-treated with phytosphingosine] results in increased activity of PARP1 protein]; [arsenic trioxide co-treated with phytosphingosine] results in increased activity of PARP1 protein; [arsenic trioxide co-treated with phytosphingosine] results in increased cleavage of PARP1 protein; Acetylcysteine inhibits the reaction [[arsenic trioxide co-treated with phytosphingosine] results in increased activity of PARP1 protein]
phytosphingosine results in increased cleavage of PARP1 protein
phytosphingosine results in increased activity of PARP1 protein		 CTD PMID:15486061 PMID:17237268 PMID:37956922 NCBI chr 1:180,396,456...180,428,564
Ensembl chr 1:180,396,489...180,428,819 		JBrowse link
G Pink1 PTEN induced putative kinase 1 decreases expression ISO phytosphingosine results in decreased expression of PINK1 protein CTD PMID:36334778 NCBI chr 4:138,040,718...138,053,631
Ensembl chr 4:138,040,720...138,053,618 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 22178
    chemical entity 22208
      atom 22170
        nonmetal atom 22055
          carbon atom 21859
            organic molecular entity 21830
              lipid 18859
                sphingolipid 218
                  glycosphingolipid 41
                    (3R,4S,5S,6R)-2-\{[(4E)-2-amino-3-hydroxyoctadec-4-en-1-yl]oxy\}-6-(hydroxymethyl)oxane-3,4,5-triol 0
                    3-O-Sulfogalactosylceramide (d18:1/18:0) 0
                    Allantoside 0
                    Alpha-D-Galactouronosylceramide II 0
                    Araliacerebroside 0
                    Asperiamide B 0
                    Catacerebroside B 0
                    Catacerebroside C 0
                    Cerebroside 1 0
                    Culinariside 0
                    Deformin 0
                    Galactosylceramide (d18:1/18:0) 0
                    Galactosylceramide (d18:1/20:0) 0
                    Ganglioside GA2 (d18:1/12:0) 0
                    Ganglioside GD2 (d18:1/25:0) 0
                    GlcAbeta-Cer(d18:1/18:0) 0
                    GlcCer d42:1 0
                    GlcCer d42:2 0
                    GlcCer(d18:0/16:0(2OH[R])) 0
                    GlcCer(d18:1(8Z)/16:0(2OH[R])) 0
                    LacCer(d18:0/14:0) 0
                    Lacto-series glycosphingolipid 0
                    Lucyobroside 0
                    N-[(2S,3S)-3-Hydroxy-1-\{[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy\}nonadecan-2-yl]octadecanimidic acid 0
                    N-[(2S,3S,4R)-1-(alpha-D-galactosyloxy)-3,4-dihydroxyoctadecan-2-yl]hexacosanethioamide 0
                    Neolacto-series glycosphingolipid 0
                    acidic glycosphingolipid + 12
                    artificial glycosphingolipid + 0
                    globoside + 3
                    glycosylceramide + 26
                    lyso-GM2 0
                    neoglycosphingolipid + 0
                    neutral glycosphingolipid + 29
                    oceanalin A 0
                    psychosine 3-sulfate zwitterion 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 22178
    subatomic particle 22170
      composite particle 22170
        hadron 22201
          baryon 22170
            nucleon 22170
              atomic nucleus 22170
                atom 22170
                  main group element atom 22104
                    p-block element atom 22104
                      carbon group element atom 21904
                        carbon atom 21859
                          organic molecular entity 21830
                            heteroorganic entity 21482
                              organochalcogen compound 20966
                                organooxygen compound 20806
                                  carbohydrates and carbohydrate derivatives 16021
                                    carbohydrate 16041
                                      carbohydrate derivative 14790
                                        liposaccharide 4177
                                          glycolipid 59
                                            glycosphingolipid 41
                                              (3R,4S,5S,6R)-2-\{[(4E)-2-amino-3-hydroxyoctadec-4-en-1-yl]oxy\}-6-(hydroxymethyl)oxane-3,4,5-triol 0
                                              3-O-Sulfogalactosylceramide (d18:1/18:0) 0
                                              Allantoside 0
                                              Alpha-D-Galactouronosylceramide II 0
                                              Araliacerebroside 0
                                              Asperiamide B 0
                                              Catacerebroside B 0
                                              Catacerebroside C 0
                                              Cerebroside 1 0
                                              Culinariside 0
                                              Deformin 0
                                              Galactosylceramide (d18:1/18:0) 0
                                              Galactosylceramide (d18:1/20:0) 0
                                              Ganglioside GA2 (d18:1/12:0) 0
                                              Ganglioside GD2 (d18:1/25:0) 0
                                              GlcAbeta-Cer(d18:1/18:0) 0
                                              GlcCer d42:1 0
                                              GlcCer d42:2 0
                                              GlcCer(d18:0/16:0(2OH[R])) 0
                                              GlcCer(d18:1(8Z)/16:0(2OH[R])) 0
                                              LacCer(d18:0/14:0) 0
                                              Lacto-series glycosphingolipid 0
                                              Lucyobroside 0
                                              N-[(2S,3S)-3-Hydroxy-1-\{[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy\}nonadecan-2-yl]octadecanimidic acid 0
                                              N-[(2S,3S,4R)-1-(alpha-D-galactosyloxy)-3,4-dihydroxyoctadecan-2-yl]hexacosanethioamide 0
                                              Neolacto-series glycosphingolipid 0
                                              acidic glycosphingolipid + 12
                                              artificial glycosphingolipid + 0
                                              globoside + 3
                                              glycosylceramide + 26
                                              lyso-GM2 0
                                              neoglycosphingolipid + 0
                                              neutral glycosphingolipid + 29
                                              oceanalin A 0
                                              psychosine 3-sulfate zwitterion 0
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