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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:fluorine molecular entity
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Accession:CHEBI:24062 term browser browse the term
Synonyms:related_synonym: fluorine compounds;   fluorine molecular entities



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cisapride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G KCNH2 potassium voltage-gated channel subfamily H member 2 multiple interactions EXP Cisapride binds to and results in decreased activity of KCNH2 protein CTD PMID:12388285 NCBI chr16:15,009,031...15,041,786
Ensembl chr16:15,009,031...15,041,504
JBrowse link
dexamethasone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AVP arginine vasopressin decreases expression EXP Dexamethasone results in decreased expression of AVP protein CTD PMID:1934541 NCBI chr24:18,183,057...18,184,827
Ensembl chr24:18,183,057...18,184,883
JBrowse link
G HSD11B1 hydroxysteroid 11-beta dehydrogenase 1 increases expression EXP Dexamethasone results in increased expression of HSD11B1 mRNA CTD PMID:21798686 NCBI chr 7:8,344,380...8,409,901
Ensembl chr 7:8,344,447...8,409,897
JBrowse link
G NPPA natriuretic peptide A increases expression EXP Dexamethasone results in increased expression of NPPA protein CTD PMID:1934541 NCBI chr 2:84,406,317...84,408,115
Ensembl chr 2:84,396,073...84,408,385
JBrowse link
fenfluramine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G EDN1 endothelin 1 increases activity EXP Fenfluramine results in increased activity of EDN1 protein CTD PMID:9918753 NCBI chr35:11,808,892...11,815,383
Ensembl chr35:11,808,892...11,815,383
JBrowse link
flufenamic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CPNE6 copine 6 decreases activity EXP Flufenamic Acid results in decreased activity of DHRS4 protein CTD PMID:17827741 NCBI chr 8:4,046,532...4,058,498
Ensembl chr 8:4,046,544...4,084,744
JBrowse link
marbofloxacin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CASP8 caspase 8 multiple interactions
increases expression
EXP TNFRSF1A mRNA promotes the reaction [marbofloxacin results in increased expression of CASP8 mRNA] CTD PMID:31005593 NCBI chr37:10,362,071...10,402,108
Ensembl chr37:10,391,048...10,401,822
JBrowse link
G FADD Fas associated via death domain increases expression EXP marbofloxacin results in increased expression of FADD mRNA CTD PMID:31005593 NCBI chr18:48,087,447...48,094,497 JBrowse link
G TNF tumor necrosis factor increases expression EXP marbofloxacin results in increased expression of TNF mRNA; marbofloxacin results in increased expression of TNF protein CTD PMID:31005593 NCBI chr12:1,074,561...1,076,425
Ensembl chr12:1,074,552...1,076,425
JBrowse link
G TNFRSF1A TNF receptor superfamily member 1A multiple interactions
increases expression
EXP TNFRSF1A mRNA promotes the reaction [marbofloxacin results in increased expression of CASP8 mRNA]; TNFRSF1A mRNA promotes the reaction [marbofloxacin results in increased expression of TRADD mRNA]
marbofloxacin results in increased expression of TNFRSF1A mRNA; marbofloxacin results in increased expression of TNFRSF1A protein
CTD PMID:31005593 NCBI chr27:38,641,837...38,654,693
Ensembl chr27:38,638,753...38,700,282
JBrowse link
G TRADD TNFRSF1A associated via death domain multiple interactions
increases expression
EXP TNFRSF1A mRNA promotes the reaction [marbofloxacin results in increased expression of TRADD mRNA] CTD PMID:31005593 NCBI chr 5:82,200,430...82,211,430
Ensembl chr 5:82,206,111...82,210,963
JBrowse link
midazolam term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4 affects metabolic processing EXP CYP3A4 protein affects the metabolism of Midazolam CTD PMID:15801540 NCBI chr 6:9,836,685...9,869,520
Ensembl chr 6:9,777,659...9,869,352
JBrowse link
G TBXAS1 thromboxane A synthase 1 affects metabolic processing EXP CYP3A5 protein affects the metabolism of Midazolam CTD PMID:15801540 NCBI chr16:8,870,283...9,032,105
Ensembl chr16:8,870,284...9,023,462
JBrowse link
ofloxacin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CAPN1 calpain 1 increases expression EXP Ofloxacin results in increased expression of CAPN1 mRNA CTD PMID:24582689 NCBI chr18:51,983,266...52,010,831
Ensembl chr18:51,983,824...52,010,757
JBrowse link
G CASP12 caspase 12 increases expression EXP Ofloxacin results in increased expression of CASP12 mRNA; Ofloxacin results in increased expression of CASP12 protein CTD PMID:24582689 NCBI chr 5:27,162,840...27,176,964
Ensembl chr 5:27,161,700...27,177,683
JBrowse link
G CASP8 caspase 8 multiple interactions
increases expression
EXP TNFRSF1A mutant form inhibits the reaction [Ofloxacin results in increased expression of CASP8 mRNA] CTD PMID:24582689 NCBI chr37:10,362,071...10,402,108
Ensembl chr37:10,391,048...10,401,822
JBrowse link
G DDIT3 DNA damage inducible transcript 3 increases expression EXP Ofloxacin results in increased expression of DDIT3 mRNA CTD PMID:24582689 NCBI chr10:1,606,693...1,612,410
Ensembl chr10:1,606,693...1,611,303
JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 increases expression EXP Ofloxacin results in increased expression of HSPA5 mRNA CTD PMID:24582689 NCBI chr 9:57,850,870...57,855,607
Ensembl chr 9:57,850,922...57,855,257
JBrowse link
G TNF tumor necrosis factor increases expression EXP Ofloxacin results in increased expression of TNF mRNA; Ofloxacin results in increased expression of TNF protein CTD PMID:24582689 NCBI chr12:1,074,561...1,076,425
Ensembl chr12:1,074,552...1,076,425
JBrowse link
G TNFRSF1A TNF receptor superfamily member 1A multiple interactions
increases expression
EXP TNFRSF1A mutant form inhibits the reaction [Ofloxacin results in increased expression of CASP8 mRNA]; TNFRSF1A mutant form inhibits the reaction [Ofloxacin results in increased expression of TRADD mRNA]
Ofloxacin results in increased expression of TNFRSF1A mRNA; Ofloxacin results in increased expression of TNFRSF1A protein
CTD PMID:24582689 NCBI chr27:38,641,837...38,654,693
Ensembl chr27:38,638,753...38,700,282
JBrowse link
G TRADD TNFRSF1A associated via death domain multiple interactions
increases expression
EXP TNFRSF1A mutant form inhibits the reaction [Ofloxacin results in increased expression of TRADD mRNA] CTD PMID:24582689 NCBI chr 5:82,200,430...82,211,430
Ensembl chr 5:82,206,111...82,210,963
JBrowse link
pitavastatin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NCF1 neutrophil cytosolic factor 1 decreases expression EXP pitavastatin results in decreased expression of NCF1 mRNA CTD PMID:15502390 NCBI chr 6:5,702,222...5,719,515
Ensembl chr 6:5,605,694...5,719,458
JBrowse link
G NOS3 nitric oxide synthase 3 increases activity
increases expression
EXP pitavastatin results in increased activity of NOS3 protein
pitavastatin results in increased expression of NOS3 mRNA
CTD PMID:15502390 NCBI chr16:15,054,196...15,072,454
Ensembl chr16:15,011,344...15,072,277
JBrowse link
G NOX4 NADPH oxidase 4 decreases expression EXP pitavastatin results in decreased expression of NOX4 mRNA CTD PMID:15502390 NCBI chr21:10,615,153...10,782,927
Ensembl chr21:10,615,970...10,775,277
JBrowse link
risperidone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DRD2 dopamine receptor D2 multiple interactions EXP Risperidone binds to and results in decreased activity of DRD2 protein CTD PMID:16948927 NCBI chr 5:19,732,842...19,795,241
Ensembl chr 5:19,732,836...19,795,241
JBrowse link
sarin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACHE acetylcholinesterase decreases activity
multiple interactions
EXP Sarin results in decreased activity of ACHE protein
[Obidoxime Chloride co-treated with Atropine] inhibits the reaction [Sarin results in decreased activity of ACHE protein]
CTD PMID:16915560 NCBI chr 6:8,874,747...8,879,926
Ensembl chr 6:8,873,584...8,879,702
JBrowse link
G BCHE butyrylcholinesterase decreases activity EXP Sarin results in decreased activity of BCHE protein CTD PMID:16915560 NCBI chr34:30,912,632...30,977,624
Ensembl chr34:30,912,632...30,977,583
JBrowse link
sulindac term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PTGS2 prostaglandin-endoperoxide synthase 2 decreases expression EXP Sulindac results in decreased expression of PTGS2 protein CTD PMID:12857884 NCBI chr 7:19,668,079...19,674,903
Ensembl chr 7:19,668,082...19,674,903
JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit decreases localization EXP Sulindac results in decreased localization of RELA protein CTD PMID:12857884 NCBI chr18:51,550,003...51,558,861
Ensembl chr18:51,550,040...51,558,875
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 402
    chemical entity 402
      molecular entity 402
        main group molecular entity 395
          p-block molecular entity 395
            halogen molecular entity 114
              fluorine molecular entity 25
                A-230 nerve agent 0
                A-232 nerve agent 0
                A-234 nerve agent 0
                BODIPY dye + 0
                difluoridohydrogenate(1-) 0
                fluoride salt + 0
                fluoridophosphate 0
                fluorine insecticide 0
                fluorine oxoacid + 0
                fluorine oxoanion + 0
                fluorine-18 molecular entity + 0
                fluorophosphoric acid 0
                flupenthixol + 0
                isopropyl methylphosphonofluoridate + 2
                organofluorine compound + 23
                sodium fluorate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 402
    subatomic particle 402
      composite particle 402
        hadron 402
          baryon 402
            nucleon 402
              atomic nucleus 402
                atom 402
                  main group element atom 395
                    p-block element atom 395
                      p-block molecular entity 395
                        halogen molecular entity 114
                          fluorine molecular entity 25
                            A-230 nerve agent 0
                            A-232 nerve agent 0
                            A-234 nerve agent 0
                            BODIPY dye + 0
                            difluoridohydrogenate(1-) 0
                            fluoride salt + 0
                            fluoridophosphate 0
                            fluorine insecticide 0
                            fluorine oxoacid + 0
                            fluorine oxoanion + 0
                            fluorine-18 molecular entity + 0
                            fluorophosphoric acid 0
                            flupenthixol + 0
                            isopropyl methylphosphonofluoridate + 2
                            organofluorine compound + 23
                            sodium fluorate 0
paths to the root