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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:fatty alcohol
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Accession:CHEBI:24026 term browser browse the term
Definition:An aliphatic alcohol consisting of a chain of 8 to 22 carbon atoms. Fatty alcohols may be saturated or unsaturated and may be branched or unbranched.
Synonyms:related_synonym: Fettalkohol;   Fettalkohole;   alcool gras;   fatty alcohols
 xref: LIPID_MAPS_class:LMFA05


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3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluoro-1-decanol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 decreases expression ISO 1H,1H,2H,2H-perfluorodecanol results in decreased expression of CYP11A1 mRNA; 1H,1H,2H,2H-perfluorodecanol results in decreased expression of CYP11A1 protein CTD PMID:20615422 NCBI chr 8:62,798,317...62,809,848
Ensembl chr 8:62,779,875...62,809,893
JBrowse link
G Cyp11b2 cytochrome P450, family 11, subfamily b, polypeptide 2 decreases expression ISO 1H,1H,2H,2H-perfluorodecanol results in decreased expression of CYP11B1 mRNA; 1H,1H,2H,2H-perfluorodecanol results in decreased expression of CYP11B1 protein CTD PMID:20615422 NCBI chr 7:116,248,759...116,255,205
Ensembl chr 7:116,156,219...116,255,167
JBrowse link
G Cyp11b3 cytochrome P450, family 11, subfamily b, polypeptide 3 decreases expression ISO 1H,1H,2H,2H-perfluorodecanol results in decreased expression of CYP11B2 mRNA; 1H,1H,2H,2H-perfluorodecanol results in decreased expression of CYP11B2 protein CTD PMID:20615422 NCBI chr 7:116,155,928...116,161,781
Ensembl chr 7:116,156,219...116,255,167
JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 decreases expression ISO 1H,1H,2H,2H-perfluorodecanol results in decreased expression of CYP17A1 mRNA; 1H,1H,2H,2H-perfluorodecanol results in decreased expression of CYP17A1 protein CTD PMID:20615422 NCBI chr 1:266,422,127...266,429,947
Ensembl chr 1:266,422,132...266,428,239
JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 decreases expression ISO 1H,1H,2H,2H-perfluorodecanol results in decreased expression of ERBB2 mRNA CTD PMID:16393665 NCBI chr10:86,367,596...86,391,728
Ensembl chr10:86,367,596...86,391,728
JBrowse link
G Esr1 estrogen receptor 1 increases activity
increases expression
multiple interactions
ISO 1H,1H,2H,2H-perfluorodecanol results in increased activity of ESR1 protein
1H,1H,2H,2H-perfluorodecanol results in increased expression of ESR1 mRNA
1H,1H,2H,2H-perfluorodecanol promotes the reaction [ESR1 protein binds to NCOA2 protein]
CTD PMID:16393665, PMID:17603182 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Esr2 estrogen receptor 2 multiple interactions
increases activity
ISO 1H,1H,2H,2H-perfluorodecanol promotes the reaction [ESR2 protein binds to NCOA2 protein]
1H,1H,2H,2H-perfluorodecanol results in increased activity of ESR2 protein
CTD PMID:17603182 NCBI chr 6:99,163,953...99,214,711
Ensembl chr 6:99,164,357...99,214,251
JBrowse link
G Ncoa2 nuclear receptor coactivator 2 multiple interactions ISO 1H,1H,2H,2H-perfluorodecanol promotes the reaction [ESR1 protein binds to NCOA2 protein]; 1H,1H,2H,2H-perfluorodecanol promotes the reaction [ESR2 protein binds to NCOA2 protein] CTD PMID:17603182 NCBI chr 5:5,466,544...5,696,540
Ensembl chr 5:5,616,483...5,694,598
JBrowse link
G Pdzk1 PDZ domain containing 1 increases expression ISO 1H,1H,2H,2H-perfluorodecanol results in increased expression of PDZK1 mRNA CTD PMID:16393665 NCBI chr 2:198,965,685...198,999,323
Ensembl chr 2:198,965,685...198,999,323
JBrowse link
G Pgr progesterone receptor increases expression ISO 1H,1H,2H,2H-perfluorodecanol results in increased expression of PGR mRNA CTD PMID:16393665 NCBI chr 8:7,128,656...7,187,796
Ensembl chr 8:7,128,656...7,187,796
JBrowse link
G Slc22a7 solute carrier family 22 member 7 increases expression EXP 1H,1H,2H,2H-perfluorodecanol results in increased expression of SLC22A7 mRNA CTD PMID:21530637 NCBI chr 9:16,925,321...16,931,119
Ensembl chr 9:16,924,520...16,931,766
JBrowse link
G Star steroidogenic acute regulatory protein decreases expression ISO 1H,1H,2H,2H-perfluorodecanol results in decreased expression of STAR mRNA; 1H,1H,2H,2H-perfluorodecanol results in decreased expression of STAR protein CTD PMID:20615422 NCBI chr16:71,036,204...71,040,847
Ensembl chr16:71,036,204...71,040,847
JBrowse link
G Tff1 trefoil factor 1 increases expression ISO 1H,1H,2H,2H-perfluorodecanol results in increased expression of TFF1 mRNA CTD PMID:16393665 NCBI chr20:9,892,124...9,895,984
Ensembl chr20:9,892,124...9,895,984
JBrowse link
decan-1-ol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1b8 aldo-keto reductase family 1, member B8 multiple interactions EXP [AKR1B8 protein co-treated with NADP] affects the oxidation of n-decyl alcohol CTD PMID:18845131 NCBI chr 4:61,772,064...61,784,637
Ensembl chr 4:61,771,970...61,828,657
JBrowse link
G Cftr CF transmembrane conductance regulator increases activity ISO n-decyl alcohol results in increased activity of CFTR protein CTD PMID:14967738 NCBI chr 4:42,693,263...42,860,679
Ensembl chr 4:42,692,836...42,860,676
JBrowse link
dodecan-1-ol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atf3 activating transcription factor 3 increases expression ISO Dodecanol analog results in increased expression of ATF3 mRNA CTD PMID:27965148 NCBI chr13:109,817,892...109,849,632
Ensembl chr13:109,817,728...109,849,632
JBrowse link
G Dnajb4 DnaJ heat shock protein family (Hsp40) member B4 increases expression ISO Dodecanol analog results in increased expression of DNAJB4 mRNA CTD PMID:27965148 NCBI chr 2:257,394,692...257,425,344
Ensembl chr 2:257,394,818...257,425,242
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression ISO Dodecanol analog results in increased expression of GCLM mRNA CTD PMID:27965148 NCBI chr 2:225,827,504...225,847,876
Ensembl chr 2:225,827,504...225,847,874
JBrowse link
hexacosan-1-ol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Chrm2 cholinergic receptor, muscarinic 2 multiple interactions EXP 1-hexacosanol inhibits the reaction [Streptozocin affects the expression of CHRM2 mRNA] CTD PMID:17989502 NCBI chr 4:64,089,028...64,091,090
Ensembl chr 4:64,088,900...64,091,090
JBrowse link
G Chrm3 cholinergic receptor, muscarinic 3 multiple interactions EXP 1-hexacosanol inhibits the reaction [Streptozocin affects the expression of CHRM3 mRNA] CTD PMID:17989502 NCBI chr17:63,990,599...64,463,222
Ensembl chr17:63,990,599...63,994,169
JBrowse link
G Nos1 nitric oxide synthase 1 multiple interactions EXP 1-hexacosanol inhibits the reaction [Streptozocin results in decreased expression of NOS1 mRNA]; 1-hexacosanol inhibits the reaction [Streptozocin results in decreased expression of NOS1 protein] CTD PMID:18528636 NCBI chr12:44,214,949...44,405,530
Ensembl chr12:44,213,943...44,520,341
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP 1-hexacosanol inhibits the reaction [Streptozocin results in increased expression of NOS2 mRNA]; 1-hexacosanol inhibits the reaction [Streptozocin results in increased expression of NOS2 protein] CTD PMID:18528636 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions EXP 1-hexacosanol inhibits the reaction [Streptozocin results in decreased expression of NOS3 protein] CTD PMID:18528636 NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP 1-hexacosanol inhibits the reaction [Streptozocin results in increased expression of TGFB1 protein] CTD PMID:16859672 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
monooctyl phthalate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ppara peroxisome proliferator activated receptor alpha affects binding ISO mono-n-octyl phthalate binds to PPARA protein CTD PMID:23843199 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752
JBrowse link
G Ppard peroxisome proliferator-activated receptor delta affects binding ISO mono-n-octyl phthalate binds to PPARB protein CTD PMID:23843199 NCBI chr20:7,818,289...7,883,482
Ensembl chr20:7,818,289...7,885,333
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma affects binding ISO mono-n-octyl phthalate binds to PPARG protein CTD PMID:23843199 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
nonan-1-ol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1b8 aldo-keto reductase family 1, member B8 multiple interactions EXP [AKR1B8 protein co-treated with NADP] affects the oxidation of 1-nonanol CTD PMID:18845131 NCBI chr 4:61,772,064...61,784,637
Ensembl chr 4:61,771,970...61,828,657
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions ISO 1-nonanol binds to and results in increased activity of NR1I3 protein alternative form CTD PMID:20869355 NCBI chr13:89,585,072...89,591,278
Ensembl chr13:89,586,283...89,591,277
JBrowse link
octan-1-ol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adh5 alcohol dehydrogenase 5 (class III), chi polypeptide increases metabolic processing
multiple interactions
ISO ADH5 protein results in increased metabolism of 1-Octanol
Pentachlorophenol inhibits the reaction [ADH5 protein results in increased metabolism of 1-Octanol]
CTD PMID:19822198 NCBI chr 2:243,728,500...243,740,907
Ensembl chr 2:243,700,784...243,740,899
JBrowse link
G Cftr CF transmembrane conductance regulator increases activity
multiple interactions
ISO 1-Octanol results in increased activity of CFTR protein; 1-Octanol results in increased activity of CFTR protein mutant form
Glyburide inhibits the reaction [1-Octanol results in increased activity of CFTR protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [1-Octanol results in increased activity of CFTR protein]
CTD PMID:14967738 NCBI chr 4:42,693,263...42,860,679
Ensembl chr 4:42,692,836...42,860,676
JBrowse link
G Tnf tumor necrosis factor increases expression ISO 1-Octanol results in increased expression of TNF protein CTD PMID:29953848 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
octan-2-ol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cftr CF transmembrane conductance regulator increases activity ISO 2-octanol results in increased activity of CFTR protein CTD PMID:14967738 NCBI chr 4:42,693,263...42,860,679
Ensembl chr 4:42,692,836...42,860,676
JBrowse link
Panaxynol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator decreases expression EXP falcarinol results in decreased expression of BAX protein CTD PMID:19800326 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator increases expression EXP falcarinol results in increased expression of BCL2 protein CTD PMID:19800326 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Casp3 caspase 3 multiple interactions
decreases expression
EXP falcarinol results in decreased expression of and results in decreased activity of CASP3 protein
falcarinol results in decreased expression of CASP3 protein modified form
CTD PMID:19800326 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions EXP falcarinol inhibits the reaction [PDGFB protein results in increased phosphorylation of CREB1 protein] CTD PMID:18199429 NCBI chr 9:71,229,753...71,298,994
Ensembl chr 9:71,230,108...71,293,435
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha increases expression EXP falcarinol results in increased expression of HIF1A protein CTD PMID:19800326 NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions EXP falcarinol inhibits the reaction [PDGFB protein results in increased phosphorylation of MAPK1 protein] CTD PMID:18199429 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions EXP falcarinol inhibits the reaction [PDGFB protein results in increased phosphorylation of MAPK3 protein] CTD PMID:18199429 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Pdgfb platelet derived growth factor subunit B multiple interactions EXP falcarinol inhibits the reaction [PDGFB protein results in increased phosphorylation of CREB1 protein]; falcarinol inhibits the reaction [PDGFB protein results in increased phosphorylation of MAPK1 protein]; falcarinol inhibits the reaction [PDGFB protein results in increased phosphorylation of MAPK3 protein] CTD PMID:18199429 NCBI chr 7:121,215,458...121,233,092
Ensembl chr 7:121,214,628...121,232,741
JBrowse link
perifosine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aifm1 apoptosis inducing factor, mitochondria associated 1 multiple interactions ISO [perifosine co-treated with Butyrates] results in increased secretion of AIFM1 protein; [perifosine co-treated with trichostatin A] results in increased secretion of AIFM1 protein; [perifosine co-treated with vorinostat] results in increased secretion of AIFM1 protein CTD PMID:15781658 NCBI chr  X:135,304,063...135,343,062
Ensembl chr  X:135,304,066...135,343,087
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
decreases phosphorylation
ISO [perifosine co-treated with Butyrates] results in decreased activity of AKT1 protein; [perifosine co-treated with trichostatin A] results in decreased activity of AKT1 protein; [perifosine co-treated with Vorinostat] results in decreased activity of AKT1 protein; AKT1 protein modified form results in decreased activity of [perifosine co-treated with Butyrates]; AKT1 protein modified form results in decreased activity of [perifosine co-treated with trichostatin A]; AKT1 protein modified form results in decreased activity of [perifosine co-treated with Vorinostat]; perifosine inhibits the reaction [cyadox results in increased phosphorylation of AKT1 protein]
perifosine results in decreased phosphorylation of AKT1 protein
[perifosine co-treated with temsirolimus] results in decreased activity of AKT1 protein
CTD PMID:15781658, PMID:21267448, PMID:30265530, PMID:31445927 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Bak1 BCL2-antagonist/killer 1 multiple interactions ISO [perifosine co-treated with Butyrates] results in decreased expression of BAK1 protein; [perifosine co-treated with trichostatin A] results in decreased expression of BAK1 protein; [perifosine co-treated with vorinostat] results in decreased expression of BAK1 protein CTD PMID:15781658 NCBI chr20:5,609,620...5,618,899
Ensembl chr20:5,609,625...5,618,260
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO [perifosine co-treated with Butyrates] results in increased activity of BAX protein; [perifosine co-treated with trichostatin A] results in increased activity of BAX protein; [perifosine co-treated with vorinostat] results in increased activity of BAX protein CTD PMID:15781658 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Casp3 caspase 3 multiple interactions
decreases expression
ISO [perifosine co-treated with Butyrates] results in increased activity of CASP3 protein; [perifosine co-treated with trichostatin A] results in increased activity of CASP3 protein; [perifosine co-treated with vorinostat] results in increased activity of CASP3 protein
perifosine results in decreased expression of CASP3 protein
CTD PMID:15781658, PMID:25416439 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp8 caspase 8 multiple interactions ISO [perifosine co-treated with Butyrates] results in increased activity of CASP8 protein; [perifosine co-treated with trichostatin A] results in increased activity of CASP8 protein; [perifosine co-treated with vorinostat] results in increased activity of CASP8 protein CTD PMID:15781658 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Cycs cytochrome c, somatic multiple interactions ISO [perifosine co-treated with Butyrates] affects the localization of CYCS protein; [perifosine co-treated with trichostatin A] affects the localization of CYCS protein; [perifosine co-treated with vorinostat] affects the localization of CYCS protein CTD PMID:15781658 NCBI chr 4:80,331,226...80,333,326
Ensembl chr 4:80,331,227...80,333,326
JBrowse link
G Egf epidermal growth factor multiple interactions ISO perifosine inhibits the reaction [cyadox results in increased expression of EGF]; perifosine inhibits the reaction [Hydrogen Peroxide results in increased expression of EGF] CTD PMID:30265530 NCBI chr 2:68,820,616...68,895,537 JBrowse link
G Fas Fas cell surface death receptor affects response to substance ISO perifosine affects the susceptibility to FAS protein CTD PMID:31445927 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790
JBrowse link
G Foxo1 forkhead box O1 multiple interactions ISO [perifosine co-treated with cyadox] results in increased expression of FOXO1 mRNA; [perifosine co-treated with Hydrogen Peroxide] results in increased expression of FOXO1 mRNA CTD PMID:30265530 NCBI chr 2:141,451,234...141,527,016
Ensembl chr 2:141,451,234...141,527,016
JBrowse link
G Lat2 linker for activation of T cells family, member 2 multiple interactions
decreases expression
decreases response to substance
ISO ixazomib inhibits the reaction [perifosine results in decreased expression of LAT2 protein]
LAT2 protein results in decreased susceptibility to perifosine
CTD PMID:23001822 NCBI chr12:25,114,099...25,128,381
Ensembl chr12:25,119,355...25,125,749
JBrowse link
G Map2k1 mitogen activated protein kinase kinase 1 multiple interactions ISO MAP2K1 protein mutant form results in decreased activity of [perifosine co-treated with Butyrates]; MAP2K1 protein mutant form results in decreased activity of [perifosine co-treated with trichostatin A]; MAP2K1 protein mutant form results in decreased activity of [perifosine co-treated with vorinostat] CTD PMID:15781658 NCBI chr 8:69,134,218...69,722,573
Ensembl chr 8:69,134,223...69,164,758
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO [perifosine co-treated with Butyrates] results in decreased activity of MAPK1 protein; [perifosine co-treated with trichostatin A] results in decreased activity of MAPK1 protein; [perifosine co-treated with vorinostat] results in decreased activity of MAPK1 protein CTD PMID:15781658 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO [perifosine co-treated with Butyrates] results in decreased activity of MAPK3 protein; [perifosine co-treated with trichostatin A] results in decreased activity of MAPK3 protein; [perifosine co-treated with vorinostat] results in decreased activity of MAPK3 protein CTD PMID:15781658 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO [perifosine co-treated with Butyrates] results in increased activity of MAPK8 protein; [perifosine co-treated with trichostatin A] results in increased activity of MAPK8 protein; [perifosine co-treated with vorinostat] results in increased activity of MAPK8 protein CTD PMID:15781658 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions ISO [perifosine co-treated with temsirolimus] results in decreased activity of MTOR protein CTD PMID:21267448 NCBI chr 5:165,263,813...165,373,967
Ensembl chr 5:165,263,800...165,373,967
JBrowse link
G Tnf tumor necrosis factor increases response to substance ISO perifosine results in increased susceptibility to TNF protein CTD PMID:31445927 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO perifosine inhibits the reaction [cyadox results in increased expression of TP53 mRNA]; perifosine inhibits the reaction [cyadox results in increased expression of TP53 protein]; perifosine inhibits the reaction [Hydrogen Peroxide results in increased expression of TP53 mRNA] CTD PMID:30265530 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
phytol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh3a2 aldehyde dehydrogenase 3 family, member A2 increases expression
multiple interactions
ISO Phytol results in increased expression of ALDH3A2 protein
PPARA protein affects the reaction [Phytol results in increased expression of ALDH3A2 protein]
CTD PMID:17015885 NCBI chr10:47,525,486...47,546,535
Ensembl chr10:47,525,493...47,546,345
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO Phytol inhibits the reaction [Benzo(a)pyrene results in increased expression of BAX protein] CTD PMID:30520250 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO Phytol inhibits the reaction [Benzo(a)pyrene results in decreased expression of BCL2 protein] CTD PMID:30520250 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Casp3 caspase 3 multiple interactions ISO Phytol inhibits the reaction [Benzo(a)pyrene results in increased expression of CASP3 protein] CTD PMID:30520250 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp9 caspase 9 multiple interactions ISO [Phytol co-treated with Benzo(a)pyrene] results in decreased expression of CASP9 protein CTD PMID:30520250 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cat catalase increases expression
multiple interactions
ISO Phytol results in increased expression of CAT
Phytol inhibits the reaction [Benzo(a)pyrene results in increased expression of CAT protein]
CTD PMID:19188468, PMID:30520250 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions ISO Phytol inhibits the reaction [Benzo(a)pyrene results in increased expression of GSR protein] CTD PMID:30520250 NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phytol promotes the reaction [alpha-MSH results in increased phosphorylation of MAPK1 protein]]; Acetylcysteine affects the reaction [Phytol promotes the reaction [alpha-MSH results in increased phosphorylation of MAPK1 protein]]; Phytol promotes the reaction [alpha-MSH results in increased phosphorylation of MAPK1 protein] CTD PMID:29486182 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phytol promotes the reaction [alpha-MSH results in increased phosphorylation of MAPK3 protein]]; Acetylcysteine affects the reaction [Phytol promotes the reaction [alpha-MSH results in increased phosphorylation of MAPK3 protein]]; Phytol promotes the reaction [alpha-MSH results in increased phosphorylation of MAPK3 protein] CTD PMID:29486182 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mitf melanocyte inducing transcription factor multiple interactions ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[Phytol inhibits the reaction [alpha-MSH results in increased expression of MITF protein]] which results in decreased ubiquitination of MITF protein]]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phytol inhibits the reaction [alpha-MSH results in increased expression of MITF protein]]; [Phytol inhibits the reaction [alpha-MSH results in increased expression of MITF protein]] which results in decreased ubiquitination of MITF protein; Acetylcysteine inhibits the reaction [Phytol inhibits the reaction [alpha-MSH results in increased expression of MITF protein]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[Phytol inhibits the reaction [alpha-MSH results in increased expression of MITF protein]] which results in decreased ubiquitination of MITF protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Phytol inhibits the reaction [alpha-MSH results in increased expression of MITF protein]]; Phytol inhibits the reaction [alpha-MSH results in increased expression of MITF protein] CTD PMID:29486182 NCBI chr 4:130,172,484...130,425,496
Ensembl chr 4:130,172,727...130,425,532
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha affects metabolic processing
multiple interactions
ISO PPARA protein affects the metabolism of Phytol
PPARA protein affects the reaction [Phytol results in increased expression of ALDH3A2 protein]
CTD PMID:17015885 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752
JBrowse link
G Ppargc1b PPARG coactivator 1 beta increases activity ISO Phytol results in increased activity of PPARGC1B protein CTD PMID:17015885 NCBI chr18:56,626,725...56,650,524
Ensembl chr18:56,626,712...56,728,968
JBrowse link
G Tyr tyrosinase multiple interactions ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phytol inhibits the reaction [alpha-MSH results in increased expression of TYR protein]]; Phytol inhibits the reaction [alpha-MSH results in increased expression of TYR protein] CTD PMID:29486182 NCBI chr 1:151,012,598...151,106,802
Ensembl chr 1:151,012,598...151,106,802
JBrowse link
G Tyrp1 tyrosinase-related protein 1 multiple interactions ISO Phytol inhibits the reaction [alpha-MSH results in increased expression of TYRP1 protein] CTD PMID:29486182 NCBI chr 5:98,387,291...98,406,083
Ensembl chr 5:98,387,291...98,406,083
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19816
    chemical entity 19816
      atom 19814
        nonmetal atom 19690
          carbon atom 19597
            organic molecular entity 19597
              lipid 17059
                fatty alcohol 59
                  (2S)-2-heptanol 0
                  (E)-3-decen-1-ol 0
                  (E)-dec-3-en-2-ol 0
                  10-undecen-1-ol 0
                  2-butyl-1-octanol + 0
                  3,7,11-trimethyldodecan-1-ol 0
                  3,7-dimethyl-3-octanol 0
                  4-hydroxynonenol + 0
                  6-[5]-ladderane-1-hexanol 0
                  9-methyldecan-1-ol 0
                  Fatty alcohol 22:2 0
                  decan-1-ol + 15
                  dodecan-1-ol + 3
                  dodecanols + 3
                  dodecenol 0
                  fatty alcohol 13:0 + 0
                  fatty alcohol 13:1 0
                  fatty alcohol 14:0 + 0
                  fatty alcohol 14:1 0
                  fatty alcohol 15:0 + 0
                  fatty alcohol 15:1 0
                  fatty alcohol 16:0 + 0
                  fatty alcohol 16:1 0
                  fatty alcohol 17:0 + 0
                  fatty alcohol 17:1 0
                  fatty alcohol 18:0 + 18
                  fatty alcohol 18:1 + 0
                  fatty alcohol 18:2 + 0
                  fatty alcohol 18:3 0
                  fatty alcohol 20:0 + 0
                  fatty alcohol 20:2 0
                  fatty alcohol 22:0 + 0
                  fatty alcohol 22:1 + 0
                  fatty alcohol 24:0 + 0
                  fatty alcohol 24:1 0
                  fatty alcohol 26:0 + 6
                  fatty alcohol 26:1 0
                  fatty alcohol 28:0 + 0
                  fatty alcohol 28:1 0
                  fatty alcohol 30:0 + 0
                  fatty alcohol 30:1 0
                  long-chain fatty alcohol + 31
                  nonacosan-10-ol + 0
                  nonan-1-ol + 2
                  oct-1-en-3-ol + 0
                  octanol + 6
                  primary fatty alcohol + 34
                  tetradecan-2-ol 0
                  undec-1-en-1-ol 0
                  undecan-2-ol 0
                  undecanol 0
                  wax ester + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19816
    subatomic particle 19814
      composite particle 19814
        hadron 19814
          baryon 19814
            nucleon 19814
              atomic nucleus 19814
                atom 19814
                  main group element atom 19702
                    p-block element atom 19702
                      chalcogen 19399
                        oxygen atom 19361
                          oxygen molecular entity 19361
                            hydroxides 19107
                              organic hydroxy compound 18661
                                alcohol 15008
                                  fatty alcohol 59
                                    (2S)-2-heptanol 0
                                    (E)-3-decen-1-ol 0
                                    (E)-dec-3-en-2-ol 0
                                    10-undecen-1-ol 0
                                    2-butyl-1-octanol + 0
                                    3,7,11-trimethyldodecan-1-ol 0
                                    3,7-dimethyl-3-octanol 0
                                    4-hydroxynonenol + 0
                                    6-[5]-ladderane-1-hexanol 0
                                    9-methyldecan-1-ol 0
                                    Fatty alcohol 22:2 0
                                    decan-1-ol + 15
                                    dodecan-1-ol + 3
                                    dodecanols + 3
                                    dodecenol 0
                                    fatty alcohol 13:0 + 0
                                    fatty alcohol 13:1 0
                                    fatty alcohol 14:0 + 0
                                    fatty alcohol 14:1 0
                                    fatty alcohol 15:0 + 0
                                    fatty alcohol 15:1 0
                                    fatty alcohol 16:0 + 0
                                    fatty alcohol 16:1 0
                                    fatty alcohol 17:0 + 0
                                    fatty alcohol 17:1 0
                                    fatty alcohol 18:0 + 18
                                    fatty alcohol 18:1 + 0
                                    fatty alcohol 18:2 + 0
                                    fatty alcohol 18:3 0
                                    fatty alcohol 20:0 + 0
                                    fatty alcohol 20:2 0
                                    fatty alcohol 22:0 + 0
                                    fatty alcohol 22:1 + 0
                                    fatty alcohol 24:0 + 0
                                    fatty alcohol 24:1 0
                                    fatty alcohol 26:0 + 6
                                    fatty alcohol 26:1 0
                                    fatty alcohol 28:0 + 0
                                    fatty alcohol 28:1 0
                                    fatty alcohol 30:0 + 0
                                    fatty alcohol 30:1 0
                                    long-chain fatty alcohol + 31
                                    nonacosan-10-ol + 0
                                    nonan-1-ol + 2
                                    oct-1-en-3-ol + 0
                                    octanol + 6
                                    primary fatty alcohol + 34
                                    tetradecan-2-ol 0
                                    undec-1-en-1-ol 0
                                    undecan-2-ol 0
                                    undecanol 0
                                    wax ester + 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.