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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:fatty alcohol
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Accession:CHEBI:24026 term browser browse the term
Definition:An aliphatic alcohol consisting of a chain of 8 to 22 carbon atoms. Fatty alcohols may be saturated or unsaturated and may be branched or unbranched.
Synonyms:related_synonym: Fettalkohol;   Fettalkohole;   alcool gras;   fatty alcohols
 xref: LIPID_MAPS_class:LMFA05


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3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluoro-1-decanol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 decreases expression ISO 1H,1H,2H,2H-perfluorodecanol results in decreased expression of CYP11A1 mRNA; 1H,1H,2H,2H-perfluorodecanol results in decreased expression of CYP11A1 protein CTD PMID:20615422 NCBI chr 9:57,998,024...58,027,031
Ensembl chr 9:58,006,411...58,027,023
JBrowse link
G Cyp11b2 cytochrome P450, family 11, subfamily b, polypeptide 2 decreases expression ISO 1H,1H,2H,2H-perfluorodecanol results in decreased expression of CYP11B2 mRNA; 1H,1H,2H,2H-perfluorodecanol results in decreased expression of CYP11B2 protein CTD PMID:20615422 NCBI chr15:74,850,618...74,856,231
Ensembl chr15:74,851,010...74,856,318
JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 decreases expression ISO 1H,1H,2H,2H-perfluorodecanol results in decreased expression of CYP17A1 mRNA; 1H,1H,2H,2H-perfluorodecanol results in decreased expression of CYP17A1 protein CTD PMID:20615422 NCBI chr19:46,667,165...46,673,000
Ensembl chr19:46,667,165...46,673,172
JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 decreases expression ISO 1H,1H,2H,2H-perfluorodecanol results in decreased expression of ERBB2 mRNA CTD PMID:16393665 NCBI chr11:98,412,484...98,437,716
Ensembl chr11:98,412,470...98,437,716
JBrowse link
G Esr1 estrogen receptor 1 (alpha) increases activity
increases expression
multiple interactions
ISO 1H,1H,2H,2H-perfluorodecanol results in increased activity of ESR1 protein
1H,1H,2H,2H-perfluorodecanol results in increased expression of ESR1 mRNA
1H,1H,2H,2H-perfluorodecanol promotes the reaction [ESR1 protein binds to NCOA2 protein]
CTD PMID:16393665, PMID:17603182 NCBI chr10:4,611,989...5,005,633
Ensembl chr10:4,611,593...5,005,614
JBrowse link
G Esr2 estrogen receptor 2 (beta) multiple interactions
increases activity
ISO 1H,1H,2H,2H-perfluorodecanol promotes the reaction [ESR2 protein binds to NCOA2 protein]
1H,1H,2H,2H-perfluorodecanol results in increased activity of ESR2 protein
CTD PMID:17603182 NCBI chr12:76,120,419...76,177,259
Ensembl chr12:76,120,419...76,177,259
JBrowse link
G Ncoa2 nuclear receptor coactivator 2 multiple interactions ISO 1H,1H,2H,2H-perfluorodecanol promotes the reaction [ESR1 protein binds to NCOA2 protein]; 1H,1H,2H,2H-perfluorodecanol promotes the reaction [ESR2 protein binds to NCOA2 protein] CTD PMID:17603182 NCBI chr 1:13,139,105...13,374,227
Ensembl chr 1:13,139,105...13,374,083
JBrowse link
G Pdzk1 PDZ domain containing 1 increases expression ISO 1H,1H,2H,2H-perfluorodecanol results in increased expression of PDZK1 mRNA CTD PMID:16393665 NCBI chr 3:96,829,456...96,870,926
Ensembl chr 3:96,829,284...96,870,926
JBrowse link
G Pgr progesterone receptor increases expression ISO 1H,1H,2H,2H-perfluorodecanol results in increased expression of PGR mRNA CTD PMID:16393665 NCBI chr 9:8,898,900...8,968,611
Ensembl chr 9:8,899,833...8,968,611
JBrowse link
G Slc22a7 solute carrier family 22 (organic anion transporter), member 7 increases expression ISO 1H,1H,2H,2H-perfluorodecanol results in increased expression of SLC22A7 mRNA CTD PMID:21530637 NCBI chr17:46,432,185...46,438,477
Ensembl chr17:46,432,183...46,438,457
JBrowse link
G Star steroidogenic acute regulatory protein decreases expression ISO 1H,1H,2H,2H-perfluorodecanol results in decreased expression of STAR mRNA; 1H,1H,2H,2H-perfluorodecanol results in decreased expression of STAR protein CTD PMID:20615422 NCBI chr 8:25,808,474...25,815,982
Ensembl chr 8:25,806,555...25,815,982
JBrowse link
G Tff1 trefoil factor 1 increases expression ISO 1H,1H,2H,2H-perfluorodecanol results in increased expression of TFF1 mRNA CTD PMID:16393665 NCBI chr17:31,161,395...31,165,060
Ensembl chr17:31,161,395...31,165,277
JBrowse link
decan-1-ol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1b8 aldo-keto reductase family 1, member B8 multiple interactions ISO [AKR1B8 protein co-treated with NADP] affects the oxidation of n-decyl alcohol CTD PMID:18845131 NCBI chr 6:34,354,146...34,368,461
Ensembl chr 6:34,354,119...34,368,463
JBrowse link
G Cftr cystic fibrosis transmembrane conductance regulator increases activity ISO n-decyl alcohol results in increased activity of CFTR protein CTD PMID:14967738 NCBI chr 6:18,170,687...18,322,770
Ensembl chr 6:18,170,687...18,322,768
JBrowse link
dodecan-1-ol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atf3 activating transcription factor 3 increases expression ISO Dodecanol analog results in increased expression of ATF3 mRNA CTD PMID:27965148 NCBI chr 1:191,170,296...191,183,333
Ensembl chr 1:191,170,296...191,218,039
JBrowse link
G Cxcl15 chemokine (C-X-C motif) ligand 15 increases expression ISO Dodecanol analog results in increased expression of CXCL8 mRNA CTD PMID:27965148 NCBI chr 5:90,794,534...90,803,067
Ensembl chr 5:90,794,534...90,803,067
JBrowse link
G Dnajb4 DnaJ heat shock protein family (Hsp40) member B4 increases expression ISO Dodecanol analog results in increased expression of DNAJB4 mRNA CTD PMID:27965148 NCBI chr 3:152,181,580...152,210,432
Ensembl chr 3:152,178,511...152,210,302
JBrowse link
G Gclm glutamate-cysteine ligase, modifier subunit increases expression ISO Dodecanol analog results in increased expression of GCLM mRNA CTD PMID:27965148 NCBI chr 3:122,245,487...122,267,215
Ensembl chr 3:122,245,557...122,270,732
JBrowse link
hexacosan-1-ol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Chrm2 cholinergic receptor, muscarinic 2, cardiac multiple interactions ISO 1-hexacosanol inhibits the reaction [Streptozocin affects the expression of CHRM2 mRNA] CTD PMID:17989502 NCBI chr 6:36,387,991...36,528,638
Ensembl chr 6:36,388,084...36,528,414
JBrowse link
G Chrm3 cholinergic receptor, muscarinic 3, cardiac multiple interactions ISO 1-hexacosanol inhibits the reaction [Streptozocin affects the expression of CHRM3 mRNA] CTD PMID:17989502 NCBI chr13:9,875,486...10,361,062
Ensembl chr13:9,875,486...10,360,847
JBrowse link
G Nos1 nitric oxide synthase 1, neuronal multiple interactions ISO 1-hexacosanol inhibits the reaction [Streptozocin results in decreased expression of NOS1 mRNA]; 1-hexacosanol inhibits the reaction [Streptozocin results in decreased expression of NOS1 protein] CTD PMID:18528636 NCBI chr 5:117,866,839...117,958,840
Ensembl chr 5:117,781,032...117,958,840
JBrowse link
G Nos2 nitric oxide synthase 2, inducible multiple interactions ISO 1-hexacosanol inhibits the reaction [Streptozocin results in increased expression of NOS2 mRNA]; 1-hexacosanol inhibits the reaction [Streptozocin results in increased expression of NOS2 protein] CTD PMID:18528636 NCBI chr11:78,920,787...78,960,226
Ensembl chr11:78,920,787...78,960,254
JBrowse link
G Nos3 nitric oxide synthase 3, endothelial cell multiple interactions ISO 1-hexacosanol inhibits the reaction [Streptozocin results in decreased expression of NOS3 protein] CTD PMID:18528636 NCBI chr 5:24,364,816...24,384,474
Ensembl chr 5:24,364,810...24,384,474
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO 1-hexacosanol inhibits the reaction [Streptozocin results in increased expression of TGFB1 protein] CTD PMID:16859672 NCBI chr 7:25,687,002...25,705,077
Ensembl chr 7:25,687,002...25,705,077
JBrowse link
monooctyl phthalate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ppara peroxisome proliferator activated receptor alpha affects binding ISO mono-n-octyl phthalate binds to PPARA protein CTD PMID:23843199 NCBI chr15:85,734,910...85,806,851
Ensembl chr15:85,734,983...85,802,819
JBrowse link
G Ppard peroxisome proliferator activator receptor delta affects binding ISO mono-n-octyl phthalate binds to PPARB protein CTD PMID:23843199 NCBI chr17:28,232,754...28,301,469
Ensembl chr17:28,232,700...28,301,474
JBrowse link
G Pparg peroxisome proliferator activated receptor gamma affects binding ISO mono-n-octyl phthalate binds to PPARG protein CTD PMID:23843199 NCBI chr 6:115,360,879...115,490,404
Ensembl chr 6:115,360,951...115,490,399
JBrowse link
nonan-1-ol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1b8 aldo-keto reductase family 1, member B8 multiple interactions ISO [AKR1B8 protein co-treated with NADP] affects the oxidation of 1-nonanol CTD PMID:18845131 NCBI chr 6:34,354,146...34,368,461
Ensembl chr 6:34,354,119...34,368,463
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions ISO 1-nonanol binds to and results in increased activity of NR1I3 protein alternative form CTD PMID:20869355 NCBI chr 1:171,213,934...171,218,845
Ensembl chr 1:171,213,970...171,220,701
JBrowse link
octan-1-ol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adh5 alcohol dehydrogenase 5 (class III), chi polypeptide increases metabolic processing
multiple interactions
ISO ADH5 protein results in increased metabolism of 1-Octanol
Pentachlorophenol inhibits the reaction [ADH5 protein results in increased metabolism of 1-Octanol]
CTD PMID:19822198 NCBI chr 3:138,437,200...138,455,499
Ensembl chr 3:138,443,093...138,455,499
JBrowse link
G Cftr cystic fibrosis transmembrane conductance regulator increases activity
multiple interactions
ISO 1-Octanol results in increased activity of CFTR protein; 1-Octanol results in increased activity of CFTR protein mutant form
Glyburide inhibits the reaction [1-Octanol results in increased activity of CFTR protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [1-Octanol results in increased activity of CFTR protein]
CTD PMID:14967738 NCBI chr 6:18,170,687...18,322,770
Ensembl chr 6:18,170,687...18,322,768
JBrowse link
G Tnf tumor necrosis factor increases expression ISO 1-Octanol results in increased expression of TNF protein CTD PMID:29953848 NCBI chr17:35,199,367...35,202,007
Ensembl chr17:35,199,381...35,202,007
JBrowse link
octan-2-ol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cftr cystic fibrosis transmembrane conductance regulator increases activity ISO 2-octanol results in increased activity of CFTR protein CTD PMID:14967738 NCBI chr 6:18,170,687...18,322,770
Ensembl chr 6:18,170,687...18,322,768
JBrowse link
Panaxynol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2-associated X protein decreases expression ISO falcarinol results in decreased expression of BAX protein CTD PMID:19800326 NCBI chr 7:45,461,695...45,466,903
Ensembl chr 7:45,461,697...45,466,898
JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 increases expression ISO falcarinol results in increased expression of BCL2 protein CTD PMID:19800326 NCBI chr 1:106,538,176...106,714,290
Ensembl chr 1:106,538,178...106,714,274
JBrowse link
G Casp3 caspase 3 multiple interactions
decreases expression
ISO falcarinol results in decreased expression of and results in decreased activity of CASP3 protein
falcarinol results in decreased expression of CASP3 protein modified form
CTD PMID:19800326 NCBI chr 8:46,617,291...46,639,698
Ensembl chr 8:46,617,291...46,639,689
JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions ISO falcarinol inhibits the reaction [PDGFB protein results in increased phosphorylation of CREB1 protein] CTD PMID:18199429 NCBI chr 1:64,532,794...64,604,548
Ensembl chr 1:64,532,645...64,604,548
JBrowse link
G Hif1a hypoxia inducible factor 1, alpha subunit increases expression ISO falcarinol results in increased expression of HIF1A protein CTD PMID:19800326 NCBI chr12:73,901,324...73,947,554
Ensembl chr12:73,901,375...73,947,530
JBrowse link
G Mapk1 mitogen-activated protein kinase 1 multiple interactions ISO falcarinol inhibits the reaction [PDGFB protein results in increased phosphorylation of MAPK1 protein] CTD PMID:18199429 NCBI chr16:16,983,382...17,047,453
Ensembl chr16:16,983,382...17,047,453
JBrowse link
G Mapk3 mitogen-activated protein kinase 3 multiple interactions ISO falcarinol inhibits the reaction [PDGFB protein results in increased phosphorylation of MAPK3 protein] CTD PMID:18199429 NCBI chr 7:126,759,626...126,765,816
Ensembl chr 7:126,759,601...126,765,819
JBrowse link
G Pdgfb platelet derived growth factor, B polypeptide multiple interactions ISO falcarinol inhibits the reaction [PDGFB protein results in increased phosphorylation of CREB1 protein]; falcarinol inhibits the reaction [PDGFB protein results in increased phosphorylation of MAPK1 protein]; falcarinol inhibits the reaction [PDGFB protein results in increased phosphorylation of MAPK3 protein] CTD PMID:18199429 NCBI chr15:79,995,865...80,024,614
Ensembl chr15:79,995,874...80,014,977
JBrowse link
perifosine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aifm1 apoptosis-inducing factor, mitochondrion-associated 1 multiple interactions ISO [perifosine co-treated with Butyrates] results in increased secretion of AIFM1 protein; [perifosine co-treated with trichostatin A] results in increased secretion of AIFM1 protein; [perifosine co-treated with vorinostat] results in increased secretion of AIFM1 protein CTD PMID:15781658 NCBI chr  X:48,474,944...48,513,563
Ensembl chr  X:48,474,944...48,513,563
JBrowse link
G Akt1 thymoma viral proto-oncogene 1 multiple interactions
decreases phosphorylation
ISO
EXP
[perifosine co-treated with Butyrates] results in decreased activity of AKT1 protein; [perifosine co-treated with trichostatin A] results in decreased activity of AKT1 protein; [perifosine co-treated with Vorinostat] results in decreased activity of AKT1 protein; AKT1 protein modified form results in decreased activity of [perifosine co-treated with Butyrates]; AKT1 protein modified form results in decreased activity of [perifosine co-treated with trichostatin A]; AKT1 protein modified form results in decreased activity of [perifosine co-treated with Vorinostat]; perifosine inhibits the reaction [cyadox results in increased phosphorylation of AKT1 protein]
perifosine results in decreased phosphorylation of AKT1 protein
[perifosine co-treated with temsirolimus] results in decreased activity of AKT1 protein
CTD PMID:15781658, PMID:21267448, PMID:30265530, PMID:31445927 NCBI chr12:112,653,821...112,674,884
Ensembl chr12:112,653,821...112,674,884
JBrowse link
G Bak1 BCL2-antagonist/killer 1 multiple interactions ISO [perifosine co-treated with Butyrates] results in decreased expression of BAK1 protein; [perifosine co-treated with trichostatin A] results in decreased expression of BAK1 protein; [perifosine co-treated with vorinostat] results in decreased expression of BAK1 protein CTD PMID:15781658 NCBI chr17:27,019,812...27,028,627
Ensembl chr17:27,019,810...27,029,009
JBrowse link
G Bax BCL2-associated X protein multiple interactions ISO [perifosine co-treated with Butyrates] results in increased activity of BAX protein; [perifosine co-treated with trichostatin A] results in increased activity of BAX protein; [perifosine co-treated with vorinostat] results in increased activity of BAX protein CTD PMID:15781658 NCBI chr 7:45,461,695...45,466,903
Ensembl chr 7:45,461,697...45,466,898
JBrowse link
G Casp3 caspase 3 multiple interactions
decreases expression
ISO [perifosine co-treated with Butyrates] results in increased activity of CASP3 protein; [perifosine co-treated with trichostatin A] results in increased activity of CASP3 protein; [perifosine co-treated with vorinostat] results in increased activity of CASP3 protein
perifosine results in decreased expression of CASP3 protein
CTD PMID:15781658, PMID:25416439 NCBI chr 8:46,617,291...46,639,698
Ensembl chr 8:46,617,291...46,639,689
JBrowse link
G Casp8 caspase 8 multiple interactions ISO [perifosine co-treated with Butyrates] results in increased activity of CASP8 protein; [perifosine co-treated with trichostatin A] results in increased activity of CASP8 protein; [perifosine co-treated with vorinostat] results in increased activity of CASP8 protein CTD PMID:15781658 NCBI chr 1:58,795,233...58,847,503
Ensembl chr 1:58,795,374...58,847,503
JBrowse link
G Cycs cytochrome c, somatic multiple interactions ISO [perifosine co-treated with Butyrates] affects the localization of CYCS protein; [perifosine co-treated with trichostatin A] affects the localization of CYCS protein; [perifosine co-treated with vorinostat] affects the localization of CYCS protein CTD PMID:15781658 NCBI chr 6:50,562,563...50,566,569
Ensembl chr 6:50,562,563...50,566,538
JBrowse link
G Egf epidermal growth factor multiple interactions ISO perifosine inhibits the reaction [cyadox results in increased expression of EGF]; perifosine inhibits the reaction [Hydrogen Peroxide results in increased expression of EGF] CTD PMID:30265530 NCBI chr 3:129,677,574...129,755,322
Ensembl chr 3:129,677,565...129,755,316
JBrowse link
G Fas Fas (TNF receptor superfamily member 6) affects response to substance ISO perifosine affects the susceptibility to FAS protein CTD PMID:31445927 NCBI chr19:34,290,647...34,327,775
Ensembl chr19:34,290,666...34,327,772
JBrowse link
G Foxo1 forkhead box O1 multiple interactions ISO [perifosine co-treated with cyadox] results in increased expression of FOXO1 mRNA; [perifosine co-treated with Hydrogen Peroxide] results in increased expression of FOXO1 mRNA CTD PMID:30265530 NCBI chr 3:52,268,337...52,350,109
Ensembl chr 3:52,268,336...52,353,221
JBrowse link
G Lat2 linker for activation of T cells family, member 2 multiple interactions
decreases expression
decreases response to substance
ISO ixazomib inhibits the reaction [perifosine results in decreased expression of LAT2 protein]
LAT2 protein results in decreased susceptibility to perifosine
CTD PMID:23001822 NCBI chr 5:134,600,103...134,619,783
Ensembl chr 5:134,600,022...134,615,025
JBrowse link
G Map2k1 mitogen-activated protein kinase kinase 1 multiple interactions ISO MAP2K1 protein mutant form results in decreased activity of [perifosine co-treated with Butyrates]; MAP2K1 protein mutant form results in decreased activity of [perifosine co-treated with trichostatin A]; MAP2K1 protein mutant form results in decreased activity of [perifosine co-treated with vorinostat] CTD PMID:15781658 NCBI chr 9:64,185,769...64,253,605
Ensembl chr 9:64,185,770...64,253,631
JBrowse link
G Mapk1 mitogen-activated protein kinase 1 multiple interactions ISO [perifosine co-treated with Butyrates] results in decreased activity of MAPK1 protein; [perifosine co-treated with trichostatin A] results in decreased activity of MAPK1 protein; [perifosine co-treated with vorinostat] results in decreased activity of MAPK1 protein CTD PMID:15781658 NCBI chr16:16,983,382...17,047,453
Ensembl chr16:16,983,382...17,047,453
JBrowse link
G Mapk3 mitogen-activated protein kinase 3 multiple interactions ISO [perifosine co-treated with Butyrates] results in decreased activity of MAPK3 protein; [perifosine co-treated with trichostatin A] results in decreased activity of MAPK3 protein; [perifosine co-treated with vorinostat] results in decreased activity of MAPK3 protein CTD PMID:15781658 NCBI chr 7:126,759,626...126,765,816
Ensembl chr 7:126,759,601...126,765,819
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO [perifosine co-treated with Butyrates] results in increased activity of MAPK8 protein; [perifosine co-treated with trichostatin A] results in increased activity of MAPK8 protein; [perifosine co-treated with vorinostat] results in increased activity of MAPK8 protein CTD PMID:15781658 NCBI chr14:33,377,898...33,447,353
Ensembl chr14:33,377,898...33,447,158
JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions EXP [perifosine co-treated with temsirolimus] results in decreased activity of MTOR protein CTD PMID:21267448 NCBI chr 4:148,448,582...148,557,685
Ensembl chr 4:148,448,611...148,557,683
JBrowse link
G Tnf tumor necrosis factor increases response to substance ISO perifosine results in increased susceptibility to TNF protein CTD PMID:31445927 NCBI chr17:35,199,367...35,202,007
Ensembl chr17:35,199,381...35,202,007
JBrowse link
G Trp53 transformation related protein 53 multiple interactions ISO perifosine inhibits the reaction [cyadox results in increased expression of TP53 mRNA]; perifosine inhibits the reaction [cyadox results in increased expression of TP53 protein]; perifosine inhibits the reaction [Hydrogen Peroxide results in increased expression of TP53 mRNA] CTD PMID:30265530 NCBI chr11:69,580,348...69,591,873
Ensembl chr11:69,580,359...69,591,873
JBrowse link
phytol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh3a2 aldehyde dehydrogenase family 3, subfamily A2 increases expression
multiple interactions
EXP Phytol results in increased expression of ALDH3A2 protein
PPARA protein affects the reaction [Phytol results in increased expression of ALDH3A2 protein]
CTD PMID:17015885 NCBI chr11:61,223,417...61,267,528
Ensembl chr11:61,223,417...61,267,464
JBrowse link
G Bax BCL2-associated X protein multiple interactions EXP Phytol inhibits the reaction [Benzo(a)pyrene results in increased expression of BAX protein] CTD PMID:30520250 NCBI chr 7:45,461,695...45,466,903
Ensembl chr 7:45,461,697...45,466,898
JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 multiple interactions EXP Phytol inhibits the reaction [Benzo(a)pyrene results in decreased expression of BCL2 protein] CTD PMID:30520250 NCBI chr 1:106,538,176...106,714,290
Ensembl chr 1:106,538,178...106,714,274
JBrowse link
G Casp3 caspase 3 multiple interactions EXP Phytol inhibits the reaction [Benzo(a)pyrene results in increased expression of CASP3 protein] CTD PMID:30520250 NCBI chr 8:46,617,291...46,639,698
Ensembl chr 8:46,617,291...46,639,689
JBrowse link
G Casp9 caspase 9 multiple interactions EXP [Phytol co-treated with Benzo(a)pyrene] results in decreased expression of CASP9 protein CTD PMID:30520250 NCBI chr 4:141,793,612...141,815,978
Ensembl chr 4:141,793,612...141,815,976
JBrowse link
G Cat catalase increases expression
multiple interactions
EXP Phytol results in increased expression of CAT
Phytol inhibits the reaction [Benzo(a)pyrene results in increased expression of CAT protein]
CTD PMID:19188468, PMID:30520250 NCBI chr 2:103,453,904...103,485,153
Ensembl chr 2:103,453,849...103,485,160
JBrowse link
G Gsr glutathione reductase multiple interactions EXP Phytol inhibits the reaction [Benzo(a)pyrene results in increased expression of GSR protein] CTD PMID:30520250 NCBI chr 8:33,653,238...33,698,162
Ensembl chr 8:33,652,523...33,698,163
JBrowse link
G Mapk1 mitogen-activated protein kinase 1 multiple interactions EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phytol promotes the reaction [alpha-MSH results in increased phosphorylation of MAPK1 protein]]; Acetylcysteine affects the reaction [Phytol promotes the reaction [alpha-MSH results in increased phosphorylation of MAPK1 protein]]; Phytol promotes the reaction [alpha-MSH results in increased phosphorylation of MAPK1 protein] CTD PMID:29486182 NCBI chr16:16,983,382...17,047,453
Ensembl chr16:16,983,382...17,047,453
JBrowse link
G Mapk3 mitogen-activated protein kinase 3 multiple interactions EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phytol promotes the reaction [alpha-MSH results in increased phosphorylation of MAPK3 protein]]; Acetylcysteine affects the reaction [Phytol promotes the reaction [alpha-MSH results in increased phosphorylation of MAPK3 protein]]; Phytol promotes the reaction [alpha-MSH results in increased phosphorylation of MAPK3 protein] CTD PMID:29486182 NCBI chr 7:126,759,626...126,765,816
Ensembl chr 7:126,759,601...126,765,819
JBrowse link
G Mitf melanogenesis associated transcription factor multiple interactions EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[Phytol inhibits the reaction [alpha-MSH results in increased expression of MITF protein]] which results in decreased ubiquitination of MITF protein]]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phytol inhibits the reaction [alpha-MSH results in increased expression of MITF protein]]; [Phytol inhibits the reaction [alpha-MSH results in increased expression of MITF protein]] which results in decreased ubiquitination of MITF protein; Acetylcysteine inhibits the reaction [Phytol inhibits the reaction [alpha-MSH results in increased expression of MITF protein]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[Phytol inhibits the reaction [alpha-MSH results in increased expression of MITF protein]] which results in decreased ubiquitination of MITF protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Phytol inhibits the reaction [alpha-MSH results in increased expression of MITF protein]]; Phytol inhibits the reaction [alpha-MSH results in increased expression of MITF protein] CTD PMID:29486182 NCBI chr 6:97,807,002...98,021,360
Ensembl chr 6:97,807,052...98,021,349
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha affects metabolic processing
multiple interactions
EXP PPARA protein affects the metabolism of Phytol
PPARA protein affects the reaction [Phytol results in increased expression of ALDH3A2 protein]
CTD PMID:17015885 NCBI chr15:85,734,910...85,806,851
Ensembl chr15:85,734,983...85,802,819
JBrowse link
G Ppargc1b peroxisome proliferative activated receptor, gamma, coactivator 1 beta increases activity EXP Phytol results in increased activity of PPARGC1B protein CTD PMID:17015885 NCBI chr18:61,291,445...61,400,756
Ensembl chr18:61,298,136...61,400,431
JBrowse link
G Tyr tyrosinase multiple interactions EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phytol inhibits the reaction [alpha-MSH results in increased expression of TYR protein]]; Phytol inhibits the reaction [alpha-MSH results in increased expression of TYR protein] CTD PMID:29486182 NCBI chr 7:87,424,771...87,493,512
Ensembl chr 7:87,424,771...87,493,512
JBrowse link
G Tyrp1 tyrosinase-related protein 1 multiple interactions EXP Phytol inhibits the reaction [alpha-MSH results in increased expression of TYRP1 protein] CTD PMID:29486182 NCBI chr 4:80,834,123...80,851,736
Ensembl chr 4:80,834,123...80,851,719
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 21538
    chemical entity 21537
      atom 21525
        nonmetal atom 21402
          carbon atom 21111
            organic molecular entity 21111
              lipid 17775
                fatty alcohol 59
                  (2S)-2-heptanol 0
                  (E)-3-decen-1-ol 0
                  (E)-dec-3-en-2-ol 0
                  10-undecen-1-ol 0
                  2-butyl-1-octanol + 0
                  3,7,11-trimethyldodecan-1-ol 0
                  3,7-dimethyl-3-octanol 0
                  4-hydroxynonenol + 0
                  6-[5]-ladderane-1-hexanol 0
                  9-methyldecan-1-ol 0
                  Fatty alcohol 22:2 0
                  decan-1-ol + 14
                  dodecan-1-ol + 4
                  dodecanols + 4
                  dodecenol 0
                  fatty alcohol 13:0 + 0
                  fatty alcohol 13:1 0
                  fatty alcohol 14:0 + 0
                  fatty alcohol 14:1 0
                  fatty alcohol 15:0 + 0
                  fatty alcohol 15:1 0
                  fatty alcohol 16:0 + 0
                  fatty alcohol 16:1 0
                  fatty alcohol 17:0 + 0
                  fatty alcohol 17:1 0
                  fatty alcohol 18:0 + 18
                  fatty alcohol 18:1 + 0
                  fatty alcohol 18:2 + 0
                  fatty alcohol 18:3 0
                  fatty alcohol 20:0 + 0
                  fatty alcohol 20:2 0
                  fatty alcohol 22:0 + 0
                  fatty alcohol 22:1 + 0
                  fatty alcohol 24:0 + 0
                  fatty alcohol 24:1 0
                  fatty alcohol 26:0 + 6
                  fatty alcohol 26:1 0
                  fatty alcohol 28:0 + 0
                  fatty alcohol 28:1 0
                  fatty alcohol 30:0 + 0
                  fatty alcohol 30:1 0
                  long-chain fatty alcohol + 31
                  nonacosan-10-ol + 0
                  nonan-1-ol + 2
                  oct-1-en-3-ol + 0
                  octanol + 6
                  primary fatty alcohol + 34
                  tetradecan-2-ol 0
                  undec-1-en-1-ol 0
                  undecan-2-ol 0
                  undecanol 0
                  wax ester + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 21538
    subatomic particle 21525
      composite particle 21525
        hadron 21525
          baryon 21525
            nucleon 21525
              atomic nucleus 21525
                atom 21525
                  main group element atom 21426
                    p-block element atom 21426
                      chalcogen 20480
                        oxygen atom 20458
                          oxygen molecular entity 20458
                            hydroxides 20113
                              organic hydroxy compound 19122
                                alcohol 15282
                                  fatty alcohol 59
                                    (2S)-2-heptanol 0
                                    (E)-3-decen-1-ol 0
                                    (E)-dec-3-en-2-ol 0
                                    10-undecen-1-ol 0
                                    2-butyl-1-octanol + 0
                                    3,7,11-trimethyldodecan-1-ol 0
                                    3,7-dimethyl-3-octanol 0
                                    4-hydroxynonenol + 0
                                    6-[5]-ladderane-1-hexanol 0
                                    9-methyldecan-1-ol 0
                                    Fatty alcohol 22:2 0
                                    decan-1-ol + 14
                                    dodecan-1-ol + 4
                                    dodecanols + 4
                                    dodecenol 0
                                    fatty alcohol 13:0 + 0
                                    fatty alcohol 13:1 0
                                    fatty alcohol 14:0 + 0
                                    fatty alcohol 14:1 0
                                    fatty alcohol 15:0 + 0
                                    fatty alcohol 15:1 0
                                    fatty alcohol 16:0 + 0
                                    fatty alcohol 16:1 0
                                    fatty alcohol 17:0 + 0
                                    fatty alcohol 17:1 0
                                    fatty alcohol 18:0 + 18
                                    fatty alcohol 18:1 + 0
                                    fatty alcohol 18:2 + 0
                                    fatty alcohol 18:3 0
                                    fatty alcohol 20:0 + 0
                                    fatty alcohol 20:2 0
                                    fatty alcohol 22:0 + 0
                                    fatty alcohol 22:1 + 0
                                    fatty alcohol 24:0 + 0
                                    fatty alcohol 24:1 0
                                    fatty alcohol 26:0 + 6
                                    fatty alcohol 26:1 0
                                    fatty alcohol 28:0 + 0
                                    fatty alcohol 28:1 0
                                    fatty alcohol 30:0 + 0
                                    fatty alcohol 30:1 0
                                    long-chain fatty alcohol + 31
                                    nonacosan-10-ol + 0
                                    nonan-1-ol + 2
                                    oct-1-en-3-ol + 0
                                    octanol + 6
                                    primary fatty alcohol + 34
                                    tetradecan-2-ol 0
                                    undec-1-en-1-ol 0
                                    undecan-2-ol 0
                                    undecanol 0
                                    wax ester + 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.