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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:fatty alcohol
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Accession:CHEBI:24026 term browser browse the term
Definition:An aliphatic alcohol consisting of a chain of 8 to 22 carbon atoms. Fatty alcohols may be saturated or unsaturated and may be branched or unbranched.
Synonyms:related_synonym: Fettalkohol;   Fettalkohole;   alcool gras;   fatty alcohols
 xref: LIPID_MAPS_class:LMFA05


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3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluoro-1-decanol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP11A1 cytochrome P450 family 11 subfamily A member 1 decreases expression EXP 1H,1H,2H,2H-perfluorodecanol results in decreased expression of CYP11A1 mRNA; 1H,1H,2H,2H-perfluorodecanol results in decreased expression of CYP11A1 protein CTD PMID:20615422 NCBI chr15:74,337,762...74,367,646
Ensembl chr15:74,337,759...74,367,646
JBrowse link
G CYP11B1 cytochrome P450 family 11 subfamily B member 1 decreases expression EXP 1H,1H,2H,2H-perfluorodecanol results in decreased expression of CYP11B1 mRNA; 1H,1H,2H,2H-perfluorodecanol results in decreased expression of CYP11B1 protein CTD PMID:20615422 NCBI chr 8:142,872,357...142,879,825
Ensembl chr 8:142,872,354...142,879,846
Ensembl chr 8:142,872,354...142,879,846
JBrowse link
G CYP11B2 cytochrome P450 family 11 subfamily B member 2 decreases expression EXP 1H,1H,2H,2H-perfluorodecanol results in decreased expression of CYP11B2 mRNA; 1H,1H,2H,2H-perfluorodecanol results in decreased expression of CYP11B2 protein CTD PMID:20615422 NCBI chr 8:142,910,559...142,917,843
Ensembl chr 8:142,910,559...142,917,843
JBrowse link
G CYP17A1 cytochrome P450 family 17 subfamily A member 1 decreases expression EXP 1H,1H,2H,2H-perfluorodecanol results in decreased expression of CYP17A1 mRNA; 1H,1H,2H,2H-perfluorodecanol results in decreased expression of CYP17A1 protein CTD PMID:20615422 NCBI chr10:102,830,531...102,837,413
Ensembl chr10:102,830,531...102,837,472
JBrowse link
G ERBB2 erb-b2 receptor tyrosine kinase 2 decreases expression EXP 1H,1H,2H,2H-perfluorodecanol results in decreased expression of ERBB2 mRNA CTD PMID:16393665 NCBI chr17:39,688,094...39,728,660
Ensembl chr17:39,687,914...39,730,426
JBrowse link
G ESR1 estrogen receptor 1 increases activity
increases expression
multiple interactions
EXP 1H,1H,2H,2H-perfluorodecanol results in increased activity of ESR1 protein
1H,1H,2H,2H-perfluorodecanol results in increased expression of ESR1 mRNA
1H,1H,2H,2H-perfluorodecanol promotes the reaction [ESR1 protein binds to NCOA2 protein]
CTD PMID:16393665, PMID:17603182 NCBI chr 6:151,654,148...152,129,619
Ensembl chr 6:151,656,691...152,129,619
JBrowse link
G ESR2 estrogen receptor 2 multiple interactions
increases activity
EXP 1H,1H,2H,2H-perfluorodecanol promotes the reaction [ESR2 protein binds to NCOA2 protein]
1H,1H,2H,2H-perfluorodecanol results in increased activity of ESR2 protein
CTD PMID:17603182 NCBI chr14:64,226,707...64,338,631
Ensembl chr14:64,084,232...64,338,112
JBrowse link
G NCOA2 nuclear receptor coactivator 2 multiple interactions EXP 1H,1H,2H,2H-perfluorodecanol promotes the reaction [ESR1 protein binds to NCOA2 protein]; 1H,1H,2H,2H-perfluorodecanol promotes the reaction [ESR2 protein binds to NCOA2 protein] CTD PMID:17603182 NCBI chr 8:70,109,770...70,405,390
Ensembl chr 8:70,109,782...70,403,808
JBrowse link
G PDZK1 PDZ domain containing 1 increases expression EXP 1H,1H,2H,2H-perfluorodecanol results in increased expression of PDZK1 mRNA CTD PMID:16393665 NCBI chr 1:145,670,852...145,708,201
Ensembl chr 1:145,670,852...145,708,148
JBrowse link
G PGR progesterone receptor increases expression EXP 1H,1H,2H,2H-perfluorodecanol results in increased expression of PGR mRNA CTD PMID:16393665 NCBI chr11:101,029,624...101,130,681
Ensembl chr11:101,029,624...101,129,813
JBrowse link
G SLC22A7 solute carrier family 22 member 7 increases expression ISO 1H,1H,2H,2H-perfluorodecanol results in increased expression of SLC22A7 mRNA CTD PMID:21530637 NCBI chr 6:43,295,710...43,305,538
Ensembl chr 6:43,295,694...43,305,538
JBrowse link
G STAR steroidogenic acute regulatory protein decreases expression EXP 1H,1H,2H,2H-perfluorodecanol results in decreased expression of STAR mRNA; 1H,1H,2H,2H-perfluorodecanol results in decreased expression of STAR protein CTD PMID:20615422 NCBI chr 8:38,142,700...38,150,952
Ensembl chr 8:38,142,700...38,150,992
JBrowse link
G TFF1 trefoil factor 1 increases expression EXP 1H,1H,2H,2H-perfluorodecanol results in increased expression of TFF1 mRNA CTD PMID:16393665 NCBI chr21:42,362,282...42,366,535
Ensembl chr21:42,362,282...42,366,535
JBrowse link
decan-1-ol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CFTR CF transmembrane conductance regulator increases activity EXP n-decyl alcohol results in increased activity of CFTR protein CTD PMID:14967738 NCBI chr 7:117,480,025...117,668,665
Ensembl chr 7:117,287,120...117,715,971
Ensembl chr 7:117,287,120...117,715,971
JBrowse link
dodecan-1-ol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATF3 activating transcription factor 3 increases expression EXP Dodecanol analog results in increased expression of ATF3 mRNA CTD PMID:27965148 NCBI chr 1:212,565,407...212,620,777
Ensembl chr 1:212,565,334...212,620,777
JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 increases expression EXP Dodecanol analog results in increased expression of CXCL8 mRNA CTD PMID:27965148 NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,541...73,743,716
JBrowse link
G DNAJB4 DnaJ heat shock protein family (Hsp40) member B4 increases expression EXP Dodecanol analog results in increased expression of DNAJB4 mRNA CTD PMID:27965148 NCBI chr 1:77,979,175...78,017,964
Ensembl chr 1:77,979,175...78,017,964
JBrowse link
G GCLM glutamate-cysteine ligase modifier subunit increases expression EXP Dodecanol analog results in increased expression of GCLM mRNA CTD PMID:27965148 NCBI chr 1:93,885,199...93,910,370
Ensembl chr 1:93,885,199...93,909,456
JBrowse link
hexacosan-1-ol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CHRM2 cholinergic receptor muscarinic 2 multiple interactions ISO 1-hexacosanol inhibits the reaction [Streptozocin affects the expression of CHRM2 mRNA] CTD PMID:17989502 NCBI chr 7:136,868,652...137,020,213
Ensembl chr 7:136,868,669...137,020,255
JBrowse link
G CHRM3 cholinergic receptor muscarinic 3 multiple interactions ISO 1-hexacosanol inhibits the reaction [Streptozocin affects the expression of CHRM3 mRNA] CTD PMID:17989502 NCBI chr 1:239,386,565...239,915,450
Ensembl chr 1:239,386,565...239,915,452
JBrowse link
G NOS1 nitric oxide synthase 1 multiple interactions ISO 1-hexacosanol inhibits the reaction [Streptozocin results in decreased expression of NOS1 mRNA]; 1-hexacosanol inhibits the reaction [Streptozocin results in decreased expression of NOS1 protein] CTD PMID:18528636 NCBI chr12:117,208,142...117,361,626
Ensembl chr12:117,208,142...117,452,170
JBrowse link
G NOS2 nitric oxide synthase 2 multiple interactions ISO 1-hexacosanol inhibits the reaction [Streptozocin results in increased expression of NOS2 mRNA]; 1-hexacosanol inhibits the reaction [Streptozocin results in increased expression of NOS2 protein] CTD PMID:18528636 NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529
JBrowse link
G NOS3 nitric oxide synthase 3 multiple interactions ISO 1-hexacosanol inhibits the reaction [Streptozocin results in decreased expression of NOS3 protein] CTD PMID:18528636 NCBI chr 7:150,991,017...151,014,588
Ensembl chr 7:150,991,017...151,014,588
JBrowse link
G TGFB1 transforming growth factor beta 1 multiple interactions ISO 1-hexacosanol inhibits the reaction [Streptozocin results in increased expression of TGFB1 protein] CTD PMID:16859672 NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922
JBrowse link
monooctyl phthalate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PPARA peroxisome proliferator activated receptor alpha affects binding EXP mono-n-octyl phthalate binds to PPARA protein CTD PMID:23843199 NCBI chr22:46,150,526...46,243,756
Ensembl chr22:46,150,521...46,243,756
JBrowse link
G PPARD peroxisome proliferator activated receptor delta affects binding EXP mono-n-octyl phthalate binds to PPARB protein CTD PMID:23843199 NCBI chr 6:35,342,558...35,428,180
Ensembl chr 6:35,342,558...35,428,191
JBrowse link
G PPARG peroxisome proliferator activated receptor gamma affects binding EXP mono-n-octyl phthalate binds to PPARG protein CTD PMID:23843199 NCBI chr 3:12,287,368...12,434,344
Ensembl chr 3:12,287,368...12,434,356
JBrowse link
nonan-1-ol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NR1I3 nuclear receptor subfamily 1 group I member 3 multiple interactions EXP 1-nonanol binds to and results in increased activity of NR1I3 protein alternative form CTD PMID:20869355 NCBI chr 1:161,229,666...161,238,623
Ensembl chr 1:161,229,666...161,238,302
Ensembl chr 1:161,229,666...161,238,302
JBrowse link
octan-1-ol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide increases metabolic processing
multiple interactions
EXP ADH5 protein results in increased metabolism of 1-Octanol
Pentachlorophenol inhibits the reaction [ADH5 protein results in increased metabolism of 1-Octanol]
CTD PMID:19822198 NCBI chr 4:99,070,978...99,088,788
Ensembl chr 4:99,070,978...99,088,801
JBrowse link
G CFTR CF transmembrane conductance regulator increases activity
multiple interactions
EXP 1-Octanol results in increased activity of CFTR protein; 1-Octanol results in increased activity of CFTR protein mutant form
Glyburide inhibits the reaction [1-Octanol results in increased activity of CFTR protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [1-Octanol results in increased activity of CFTR protein]
CTD PMID:14967738 NCBI chr 7:117,480,025...117,668,665
Ensembl chr 7:117,287,120...117,715,971
Ensembl chr 7:117,287,120...117,715,971
JBrowse link
G TNF tumor necrosis factor increases expression EXP 1-Octanol results in increased expression of TNF protein CTD PMID:29953848 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
JBrowse link
octan-2-ol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CFTR CF transmembrane conductance regulator increases activity EXP 2-octanol results in increased activity of CFTR protein CTD PMID:14967738 NCBI chr 7:117,480,025...117,668,665
Ensembl chr 7:117,287,120...117,715,971
Ensembl chr 7:117,287,120...117,715,971
JBrowse link
Panaxynol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BAX BCL2 associated X, apoptosis regulator decreases expression ISO falcarinol results in decreased expression of BAX protein CTD PMID:19800326 NCBI chr19:48,954,825...48,961,798
Ensembl chr19:48,954,815...48,961,798
JBrowse link
G BCL2 BCL2 apoptosis regulator increases expression ISO falcarinol results in increased expression of BCL2 protein CTD PMID:19800326 NCBI chr18:63,123,346...63,320,280
Ensembl chr18:63,123,346...63,320,128
JBrowse link
G CASP3 caspase 3 multiple interactions
decreases expression
ISO falcarinol results in decreased expression of and results in decreased activity of CASP3 protein
falcarinol results in decreased expression of CASP3 protein modified form
CTD PMID:19800326 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,649,509
JBrowse link
G CREB1 cAMP responsive element binding protein 1 multiple interactions ISO falcarinol inhibits the reaction [PDGFB protein results in increased phosphorylation of CREB1 protein] CTD PMID:18199429 NCBI chr 2:207,529,943...207,605,988
Ensembl chr 2:207,529,737...207,605,988
JBrowse link
G HIF1A hypoxia inducible factor 1 subunit alpha increases expression ISO falcarinol results in increased expression of HIF1A protein CTD PMID:19800326 NCBI chr14:61,695,513...61,748,259
Ensembl chr14:61,695,513...61,748,259
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions ISO falcarinol inhibits the reaction [PDGFB protein results in increased phosphorylation of MAPK1 protein] CTD PMID:18199429 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,754,500...21,867,680
Ensembl chr22:21,754,500...21,867,680
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions ISO falcarinol inhibits the reaction [PDGFB protein results in increased phosphorylation of MAPK3 protein] CTD PMID:18199429 NCBI chr16:30,114,105...30,123,309
Ensembl chr16:30,114,105...30,123,506
JBrowse link
G PDGFB platelet derived growth factor subunit B multiple interactions ISO falcarinol inhibits the reaction [PDGFB protein results in increased phosphorylation of CREB1 protein]; falcarinol inhibits the reaction [PDGFB protein results in increased phosphorylation of MAPK1 protein]; falcarinol inhibits the reaction [PDGFB protein results in increased phosphorylation of MAPK3 protein] CTD PMID:18199429 NCBI chr22:39,223,359...39,244,982
Ensembl chr22:39,223,359...39,244,982
JBrowse link
perifosine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AIFM1 apoptosis inducing factor mitochondria associated 1 multiple interactions EXP [perifosine co-treated with Butyrates] results in increased secretion of AIFM1 protein; [perifosine co-treated with trichostatin A] results in increased secretion of AIFM1 protein; [perifosine co-treated with vorinostat] results in increased secretion of AIFM1 protein CTD PMID:15781658 NCBI chr  X:130,129,362...130,165,841
Ensembl chr  X:130,124,666...130,165,879
Ensembl chr  X:130,124,666...130,165,879
JBrowse link
G AKT1 AKT serine/threonine kinase 1 multiple interactions
decreases phosphorylation
EXP
ISO
[perifosine co-treated with Butyrates] results in decreased activity of AKT1 protein; [perifosine co-treated with trichostatin A] results in decreased activity of AKT1 protein; [perifosine co-treated with Vorinostat] results in decreased activity of AKT1 protein; AKT1 protein modified form results in decreased activity of [perifosine co-treated with Butyrates]; AKT1 protein modified form results in decreased activity of [perifosine co-treated with trichostatin A]; AKT1 protein modified form results in decreased activity of [perifosine co-treated with Vorinostat]; perifosine inhibits the reaction [cyadox results in increased phosphorylation of AKT1 protein]
perifosine results in decreased phosphorylation of AKT1 protein
[perifosine co-treated with temsirolimus] results in decreased activity of AKT1 protein
CTD PMID:15781658, PMID:21267448, PMID:30265530, PMID:31445927 NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,751
JBrowse link
G BAK1 BCL2 antagonist/killer 1 multiple interactions EXP [perifosine co-treated with Butyrates] results in decreased expression of BAK1 protein; [perifosine co-treated with trichostatin A] results in decreased expression of BAK1 protein; [perifosine co-treated with vorinostat] results in decreased expression of BAK1 protein CTD PMID:15781658 NCBI chr 6:33,572,552...33,580,296
Ensembl chr 6:33,572,547...33,580,293
JBrowse link
G BAX BCL2 associated X, apoptosis regulator multiple interactions EXP [perifosine co-treated with Butyrates] results in increased activity of BAX protein; [perifosine co-treated with trichostatin A] results in increased activity of BAX protein; [perifosine co-treated with vorinostat] results in increased activity of BAX protein CTD PMID:15781658 NCBI chr19:48,954,825...48,961,798
Ensembl chr19:48,954,815...48,961,798
JBrowse link
G CASP3 caspase 3 multiple interactions
decreases expression
EXP [perifosine co-treated with Butyrates] results in increased activity of CASP3 protein; [perifosine co-treated with trichostatin A] results in increased activity of CASP3 protein; [perifosine co-treated with vorinostat] results in increased activity of CASP3 protein
perifosine results in decreased expression of CASP3 protein
CTD PMID:15781658, PMID:25416439 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,649,509
JBrowse link
G CASP8 caspase 8 multiple interactions EXP [perifosine co-treated with Butyrates] results in increased activity of CASP8 protein; [perifosine co-treated with trichostatin A] results in increased activity of CASP8 protein; [perifosine co-treated with vorinostat] results in increased activity of CASP8 protein CTD PMID:15781658 NCBI chr 2:201,233,443...201,287,711
Ensembl chr 2:201,233,443...201,287,711
JBrowse link
G CYCS cytochrome c, somatic multiple interactions EXP [perifosine co-treated with Butyrates] affects the localization of CYCS protein; [perifosine co-treated with trichostatin A] affects the localization of CYCS protein; [perifosine co-treated with Vorinostat] affects the localization of CYCS protein CTD PMID:15781658 NCBI chr 7:25,118,656...25,125,260
Ensembl chr 7:25,118,656...25,125,260
Ensembl chr 7:25,118,656...25,125,260
JBrowse link
G EGF epidermal growth factor multiple interactions EXP perifosine inhibits the reaction [cyadox results in increased expression of EGF]; perifosine inhibits the reaction [Hydrogen Peroxide results in increased expression of EGF] CTD PMID:30265530 NCBI chr 4:109,912,883...110,013,766
Ensembl chr 4:109,912,883...110,013,766
JBrowse link
G FAS Fas cell surface death receptor affects response to substance EXP perifosine affects the susceptibility to FAS protein CTD PMID:31445927 NCBI chr10:88,968,429...89,017,059
Ensembl chr10:88,990,531...89,017,059
JBrowse link
G FOXO1 forkhead box O1 multiple interactions EXP [perifosine co-treated with cyadox] results in increased expression of FOXO1 mRNA; [perifosine co-treated with Hydrogen Peroxide] results in increased expression of FOXO1 mRNA CTD PMID:30265530 NCBI chr13:40,555,667...40,666,641
Ensembl chr13:40,555,667...40,666,641
Ensembl chr13:40,555,667...40,666,641
JBrowse link
G LAT2 linker for activation of T cells family member 2 multiple interactions
decreases response to substance
decreases expression
EXP ixazomib inhibits the reaction [perifosine results in decreased expression of LAT2 protein]
LAT2 protein results in decreased susceptibility to perifosine
CTD PMID:23001822 NCBI chr 7:74,210,006...74,229,834
Ensembl chr 7:74,199,652...74,229,834
JBrowse link
G MAP2K1 mitogen-activated protein kinase kinase 1 multiple interactions EXP MAP2K1 protein mutant form results in decreased activity of [perifosine co-treated with Butyrates]; MAP2K1 protein mutant form results in decreased activity of [perifosine co-treated with trichostatin A]; MAP2K1 protein mutant form results in decreased activity of [perifosine co-treated with Vorinostat] CTD PMID:15781658 NCBI chr15:66,386,912...66,491,544
Ensembl chr15:66,386,817...66,492,312
Ensembl chr15:66,386,817...66,492,312
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions EXP [perifosine co-treated with Butyrates] results in decreased activity of MAPK1 protein; [perifosine co-treated with trichostatin A] results in decreased activity of MAPK1 protein; [perifosine co-treated with vorinostat] results in decreased activity of MAPK1 protein CTD PMID:15781658 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,754,500...21,867,680
Ensembl chr22:21,754,500...21,867,680
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions EXP [perifosine co-treated with Butyrates] results in decreased activity of MAPK3 protein; [perifosine co-treated with trichostatin A] results in decreased activity of MAPK3 protein; [perifosine co-treated with vorinostat] results in decreased activity of MAPK3 protein CTD PMID:15781658 NCBI chr16:30,114,105...30,123,309
Ensembl chr16:30,114,105...30,123,506
JBrowse link
G MAPK8 mitogen-activated protein kinase 8 multiple interactions EXP [perifosine co-treated with Butyrates] results in increased activity of MAPK8 protein; [perifosine co-treated with trichostatin A] results in increased activity of MAPK8 protein; [perifosine co-treated with vorinostat] results in increased activity of MAPK8 protein CTD PMID:15781658 NCBI chr10:48,306,673...48,439,360
Ensembl chr10:48,306,639...48,439,360
JBrowse link
G MTOR mechanistic target of rapamycin kinase multiple interactions ISO [perifosine co-treated with temsirolimus] results in decreased activity of MTOR protein CTD PMID:21267448 NCBI chr 1:11,106,535...11,273,497
Ensembl chr 1:11,106,535...11,262,551
JBrowse link
G TNF tumor necrosis factor increases response to substance EXP perifosine results in increased susceptibility to TNF protein CTD PMID:31445927 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
JBrowse link
G TP53 tumor protein p53 multiple interactions EXP perifosine inhibits the reaction [cyadox results in increased expression of TP53 mRNA]; perifosine inhibits the reaction [cyadox results in increased expression of TP53 protein]; perifosine inhibits the reaction [Hydrogen Peroxide results in increased expression of TP53 mRNA] CTD PMID:30265530 NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,538
Ensembl chr17:7,661,779...7,687,538
JBrowse link
phytol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALDH3A2 aldehyde dehydrogenase 3 family member A2 increases expression
multiple interactions
ISO Phytol results in increased expression of ALDH3A2 protein
PPARA protein affects the reaction [Phytol results in increased expression of ALDH3A2 protein]
CTD PMID:17015885 NCBI chr17:19,648,136...19,677,596
Ensembl chr17:19,648,136...19,685,760
JBrowse link
G BAX BCL2 associated X, apoptosis regulator multiple interactions ISO Phytol inhibits the reaction [Benzo(a)pyrene results in increased expression of BAX protein] CTD PMID:30520250 NCBI chr19:48,954,825...48,961,798
Ensembl chr19:48,954,815...48,961,798
JBrowse link
G BCL2 BCL2 apoptosis regulator multiple interactions ISO Phytol inhibits the reaction [Benzo(a)pyrene results in decreased expression of BCL2 protein] CTD PMID:30520250 NCBI chr18:63,123,346...63,320,280
Ensembl chr18:63,123,346...63,320,128
JBrowse link
G CASP3 caspase 3 multiple interactions ISO Phytol inhibits the reaction [Benzo(a)pyrene results in increased expression of CASP3 protein] CTD PMID:30520250 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,649,509
JBrowse link
G CASP9 caspase 9 multiple interactions ISO [Phytol co-treated with Benzo(a)pyrene] results in decreased expression of CASP9 protein CTD PMID:30520250 NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534
JBrowse link
G CAT catalase increases expression
multiple interactions
ISO Phytol results in increased expression of CAT
Phytol inhibits the reaction [Benzo(a)pyrene results in increased expression of CAT protein]
CTD PMID:19188468, PMID:30520250 NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060
JBrowse link
G GSR glutathione-disulfide reductase multiple interactions ISO Phytol inhibits the reaction [Benzo(a)pyrene results in increased expression of GSR protein] CTD PMID:30520250 NCBI chr 8:30,678,066...30,727,846
Ensembl chr 8:30,678,066...30,727,846
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phytol promotes the reaction [alpha-MSH results in increased phosphorylation of MAPK1 protein]]; Acetylcysteine affects the reaction [Phytol promotes the reaction [alpha-MSH results in increased phosphorylation of MAPK1 protein]]; Phytol promotes the reaction [alpha-MSH results in increased phosphorylation of MAPK1 protein] CTD PMID:29486182 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,754,500...21,867,680
Ensembl chr22:21,754,500...21,867,680
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phytol promotes the reaction [alpha-MSH results in increased phosphorylation of MAPK3 protein]]; Acetylcysteine affects the reaction [Phytol promotes the reaction [alpha-MSH results in increased phosphorylation of MAPK3 protein]]; Phytol promotes the reaction [alpha-MSH results in increased phosphorylation of MAPK3 protein] CTD PMID:29486182 NCBI chr16:30,114,105...30,123,309
Ensembl chr16:30,114,105...30,123,506
JBrowse link
G MITF melanocyte inducing transcription factor multiple interactions ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[Phytol inhibits the reaction [alpha-MSH results in increased expression of MITF protein]] which results in decreased ubiquitination of MITF protein]]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phytol inhibits the reaction [alpha-MSH results in increased expression of MITF protein]]; [Phytol inhibits the reaction [alpha-MSH results in increased expression of MITF protein]] which results in decreased ubiquitination of MITF protein; Acetylcysteine inhibits the reaction [Phytol inhibits the reaction [alpha-MSH results in increased expression of MITF protein]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[Phytol inhibits the reaction [alpha-MSH results in increased expression of MITF protein]] which results in decreased ubiquitination of MITF protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Phytol inhibits the reaction [alpha-MSH results in increased expression of MITF protein]]; Phytol inhibits the reaction [alpha-MSH results in increased expression of MITF protein] CTD PMID:29486182 NCBI chr 3:69,739,464...69,968,332
Ensembl chr 3:69,739,464...69,968,336
Ensembl chr 3:69,739,464...69,968,336
JBrowse link
G PPARA peroxisome proliferator activated receptor alpha affects metabolic processing
multiple interactions
ISO PPARA protein affects the metabolism of Phytol
PPARA protein affects the reaction [Phytol results in increased expression of ALDH3A2 protein]
CTD PMID:17015885 NCBI chr22:46,150,526...46,243,756
Ensembl chr22:46,150,521...46,243,756
JBrowse link
G PPARGC1B PPARG coactivator 1 beta increases activity ISO Phytol results in increased activity of PPARGC1B protein CTD PMID:17015885 NCBI chr 5:149,730,302...149,857,861
Ensembl chr 5:149,730,298...149,855,022
JBrowse link
G TYR tyrosinase multiple interactions ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phytol inhibits the reaction [alpha-MSH results in increased expression of TYR protein]]; Phytol inhibits the reaction [alpha-MSH results in increased expression of TYR protein] CTD PMID:29486182 NCBI chr11:89,177,565...89,295,759
Ensembl chr11:89,177,875...89,295,759
JBrowse link
G TYRP1 tyrosinase related protein 1 multiple interactions ISO Phytol inhibits the reaction [alpha-MSH results in increased expression of TYRP1 protein] CTD PMID:29486182 NCBI chr 9:12,693,375...12,710,285
Ensembl chr 9:12,685,439...12,710,285
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 24370
    chemical entity 24338
      atom 24327
        nonmetal atom 24029
          carbon atom 23906
            organic molecular entity 23906
              lipid 19679
                fatty alcohol 59
                  (2S)-2-heptanol 0
                  (E)-3-decen-1-ol 0
                  (E)-dec-3-en-2-ol 0
                  10-undecen-1-ol 0
                  2-butyl-1-octanol + 0
                  3,7,11-trimethyldodecan-1-ol 0
                  3,7-dimethyl-3-octanol 0
                  4-hydroxynonenol + 0
                  6-[5]-ladderane-1-hexanol 0
                  9-methyldecan-1-ol 0
                  Fatty alcohol 22:2 0
                  decan-1-ol + 14
                  dodecan-1-ol + 4
                  dodecanols + 4
                  dodecenol 0
                  fatty alcohol 13:0 + 0
                  fatty alcohol 13:1 0
                  fatty alcohol 14:0 + 0
                  fatty alcohol 14:1 0
                  fatty alcohol 15:0 + 0
                  fatty alcohol 15:1 0
                  fatty alcohol 16:0 + 0
                  fatty alcohol 16:1 0
                  fatty alcohol 17:0 + 0
                  fatty alcohol 17:1 0
                  fatty alcohol 18:0 + 18
                  fatty alcohol 18:1 + 0
                  fatty alcohol 18:2 + 0
                  fatty alcohol 18:3 0
                  fatty alcohol 20:0 + 0
                  fatty alcohol 20:2 0
                  fatty alcohol 22:0 + 0
                  fatty alcohol 22:1 + 0
                  fatty alcohol 24:0 + 0
                  fatty alcohol 24:1 0
                  fatty alcohol 26:0 + 6
                  fatty alcohol 26:1 0
                  fatty alcohol 28:0 + 0
                  fatty alcohol 28:1 0
                  fatty alcohol 30:0 + 0
                  fatty alcohol 30:1 0
                  long-chain fatty alcohol + 31
                  nonacosan-10-ol + 0
                  nonan-1-ol + 1
                  oct-1-en-3-ol + 0
                  octanol + 6
                  primary fatty alcohol + 34
                  tetradecan-2-ol 0
                  undec-1-en-1-ol 0
                  undecan-2-ol 0
                  undecanol 0
                  wax ester + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 24370
    subatomic particle 24327
      composite particle 24327
        hadron 24327
          baryon 24327
            nucleon 24327
              atomic nucleus 24327
                atom 24327
                  main group element atom 24173
                    p-block element atom 24173
                      chalcogen 23198
                        oxygen atom 23071
                          oxygen molecular entity 23071
                            hydroxides 22317
                              organic hydroxy compound 20691
                                alcohol 15768
                                  fatty alcohol 59
                                    (2S)-2-heptanol 0
                                    (E)-3-decen-1-ol 0
                                    (E)-dec-3-en-2-ol 0
                                    10-undecen-1-ol 0
                                    2-butyl-1-octanol + 0
                                    3,7,11-trimethyldodecan-1-ol 0
                                    3,7-dimethyl-3-octanol 0
                                    4-hydroxynonenol + 0
                                    6-[5]-ladderane-1-hexanol 0
                                    9-methyldecan-1-ol 0
                                    Fatty alcohol 22:2 0
                                    decan-1-ol + 14
                                    dodecan-1-ol + 4
                                    dodecanols + 4
                                    dodecenol 0
                                    fatty alcohol 13:0 + 0
                                    fatty alcohol 13:1 0
                                    fatty alcohol 14:0 + 0
                                    fatty alcohol 14:1 0
                                    fatty alcohol 15:0 + 0
                                    fatty alcohol 15:1 0
                                    fatty alcohol 16:0 + 0
                                    fatty alcohol 16:1 0
                                    fatty alcohol 17:0 + 0
                                    fatty alcohol 17:1 0
                                    fatty alcohol 18:0 + 18
                                    fatty alcohol 18:1 + 0
                                    fatty alcohol 18:2 + 0
                                    fatty alcohol 18:3 0
                                    fatty alcohol 20:0 + 0
                                    fatty alcohol 20:2 0
                                    fatty alcohol 22:0 + 0
                                    fatty alcohol 22:1 + 0
                                    fatty alcohol 24:0 + 0
                                    fatty alcohol 24:1 0
                                    fatty alcohol 26:0 + 6
                                    fatty alcohol 26:1 0
                                    fatty alcohol 28:0 + 0
                                    fatty alcohol 28:1 0
                                    fatty alcohol 30:0 + 0
                                    fatty alcohol 30:1 0
                                    long-chain fatty alcohol + 31
                                    nonacosan-10-ol + 0
                                    nonan-1-ol + 1
                                    oct-1-en-3-ol + 0
                                    octanol + 6
                                    primary fatty alcohol + 34
                                    tetradecan-2-ol 0
                                    undec-1-en-1-ol 0
                                    undecan-2-ol 0
                                    undecanol 0
                                    wax ester + 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.