N-ethyl-N-nitrosourea - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	N-ethyl-N-nitrosourea	go back to main search page
Accession:	CHEBI:23995	browse the term
Definition:	A member of the class of N-nitrosoureas that is urea in which one of the nitrogens is substituted by ethyl and nitroso groups.
Synonyms:	related_synonym:	1-(Aminocarbonyl)-1-ethyl-2-oxohydrazine; 1-Ethyl-1-nitrosourea; Aethylnitroso-harnstoff; ENU; Ethyl nitrosourea; Formula=C3H7N3O2; InChI=1S/C3H7N3O2/c1-2-6(5-8)3(4)7/h2H2,1H3,(H2,4,7); InChIKey=FUSGACRLAFQQRL-UHFFFAOYSA-N; N-Ethyl-N-nitroso carbamide; N-Ethyl-N-nitroso-urea; N-Ethylnitrosourea; NEU; SMILES=CCN(N=O)C(N)=O
	xref:	CAS:759-73-9; KEGG:C19178
	xref_mesh:	MESH:D005038
	xref:	PMID:11732210; PMID:11853764; PMID:11880538; PMID:16423555; PMID:21861612; PMID:22012195; PMID:22238669; PMID:23551873; PMID:24175309; PMID:8603364; Reaxys:1761174; Wikipedia:ENU

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Genes (513)

N-ethyl-N-nitrosourea

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

alanyl-tRNA synthetase 1

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of AARS1 mRNA

NCBI chr19:55,906,694...55,930,499
Ensembl chr19:38,999,163...39,021,147

G

ATP binding cassette subfamily D member 1

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of ABCD1 mRNA

NCBI chr X:156,579,669...156,601,448
Ensembl chr X:151,428,578...151,450,115

G

ATP binding cassette subfamily G member 5

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of ABCG5 gene

NCBI chr 6:15,717,936...15,743,376
Ensembl chr 6:9,965,118...9,990,563

G

acetyl-CoA carboxylase alpha

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of ACACA intron

NCBI chr10:69,511,627...69,773,888
Ensembl chr10:69,014,170...69,276,457

G

acyl-CoA dehydrogenase, long chain

increases expression

Ethylnitrosourea results in increased expression of ACADL mRNA

NCBI chr 9:75,783,689...75,822,077
Ensembl chr 9:68,333,980...68,372,220

G

actinin alpha 4

increases expression

Ethylnitrosourea results in increased expression of ACTN4 mRNA

NCBI chr 1:93,310,294...93,379,369
Ensembl chr 1:84,182,788...84,251,847

G

ADAM metallopeptidase domain 1a

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of ADAM1A mRNA

NCBI chr12:40,674,460...40,680,988
Ensembl chr12:35,017,315...35,020,311

G

adhesion G protein-coupled receptor F4

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of ADGRF4 gene

NCBI chr 9:25,769,265...25,800,438
Ensembl chr 9:18,272,050...18,303,217

G

adhesion G protein-coupled receptor V1

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of ADGRV1 gene

NCBI chr 2:13,067,149...13,647,407
Ensembl chr 2:11,331,442...11,911,688

G

adrenoceptor alpha 2B

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of ADRA2B gene

NCBI chr 3:135,038,481...135,042,527
Ensembl chr 3:114,585,169...114,589,355

G

apoptosis enhancing nuclease

increases expression

Ethylnitrosourea results in increased expression of AEN mRNA

NCBI chr 1:142,224,499...142,233,902
Ensembl chr 1:132,815,142...132,824,523

G

ALF transcription elongation factor 1

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of AFF1 gene

NCBI chr14:6,165,864...6,328,848
Ensembl chr14:5,863,961...6,024,729

G

ArfGAP with GTPase domain, ankyrin repeat and PH domain 1

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of AGAP1 mRNA

NCBI chr 9:97,487,382...97,922,870
Ensembl chr 9:90,039,605...90,470,958

G

aryl-hydrocarbon receptor-interacting protein

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of AIP gene

NCBI chr 1:210,837,473...210,848,691
Ensembl chr 1:201,407,288...201,419,122

G

AKT serine/threonine kinase 1

increases phosphorylation

Ethylnitrosourea results in increased phosphorylation of AKT1 protein

NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:131,713,720...131,733,921

G

aldehyde dehydrogenase 1 family, member L2

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of ALDH1L2 mRNA

NCBI chr 7:22,141,872...22,193,403
Ensembl chr 7:20,254,233...20,305,776

G

ALG5, dolichyl-phosphate beta-glucosyltransferase

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of ALG5 gene

NCBI chr 2:141,087,126...141,101,397
Ensembl chr 2:138,936,993...138,951,216

G

ALK receptor tyrosine kinase

multiple interactions
increases mutagenesis

[Ethylnitrosourea results in increased mutagenesis of ALK protein] inhibits the reaction [crizotinib results in decreased phosphorylation of ALK protein]; [Ethylnitrosourea results in increased mutagenesis of ALK protein] which results in decreased susceptibility to crizotinib; [Ethylnitrosourea results in increased mutagenesis of ALK protein] which results in decreased susceptibility to NVP-TAE684

PMID:21948233 PMID:22034911

NCBI chr 6:28,631,431...29,351,321
Ensembl chr 6:22,880,625...23,598,034

G

ALMS1, centrosome and basal body associated protein

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of ALMS1 mRNA

NCBI chr 4:119,683,085...119,783,471
Ensembl chr 4:118,125,607...118,226,005

G

ankyrin repeat domain containing 11

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of ANKRD11 gene

NCBI chr19:67,848,836...68,007,491
Ensembl chr19:50,940,299...51,098,962

G

ankyrin repeat domain 35

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of ANKRD35 intron

NCBI chr 2:186,895,896...186,915,903
Ensembl chr 2:184,207,071...184,227,063

G

ankyrin repeat domain 6

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of ANKRD6 mRNA

NCBI chr 5:51,999,225...52,139,623
Ensembl chr 5:47,202,873...47,343,090

G

ANTXR cell adhesion molecule 1

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of ANTXR1 intron

NCBI chr 4:121,148,102...121,335,549
Ensembl chr 4:119,590,771...119,778,232

G

amine oxidase, copper containing 3

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of AOC3 intron

NCBI chr10:86,773,018...86,780,961

G

adaptor related protein complex 2 subunit alpha 1

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of AP2A1 exon

NCBI chr 1:104,520,789...104,550,655
Ensembl chr 1:95,384,309...95,414,147

G

adaptor related protein complex 2 subunit mu 1

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of AP2M1 gene

NCBI chr11:93,859,690...93,868,600
Ensembl chr11:80,328,041...80,364,140

G

APC regulator of WNT signaling pathway

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of APC gene

NCBI chr18:26,138,382...26,196,021
Ensembl chr18:25,864,222...25,922,696

G

apelin receptor

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of APLNR 3' UTR

NCBI chr 3:90,624,055...90,627,700
Ensembl chr 3:70,217,385...70,221,050

G

aquaporin 2

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of AQP2 exon

NCBI chr 7:132,590,286...132,595,321
Ensembl chr 7:130,711,413...130,716,468

G

archain 1

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of ARCN1 gene

NCBI chr 8:53,954,401...53,979,005
Ensembl chr 8:45,057,619...45,082,247

G

ARF like GTPase 13B

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of ARL13B gene

NCBI chr11:13,597,538...13,663,681
Ensembl chr11:150,955...217,197

G

agouti signaling protein

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of A gene

PMID:9475716 PMID:10517996

NCBI chr 3:163,933,768...164,021,377
Ensembl chr 3:143,555,696...143,561,171

G

activating transcription factor 7 interacting protein

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of ATF7IP mRNA

NCBI chr 4:171,117,122...171,202,871
Ensembl chr 4:169,385,872...169,471,650

G

autophagy related 12

multiple interactions
decreases expression

Quercetin inhibits the reaction [Ethylnitrosourea results in decreased expression of ATG12 protein]

NCBI chr18:41,638,841...41,649,311
Ensembl chr18:39,452,191...39,462,418

G

ATRX, chromatin remodeler

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of ATRX gene

NCBI chr X:74,916,548...75,062,880
Ensembl chr X:70,850,981...70,997,330

G

arginine vasopressin receptor 1A

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of AVPR1A gene

NCBI chr 7:59,999,743...60,003,667
Ensembl chr 7:58,114,284...58,122,215

G

BCL2-associated agonist of cell death

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of BAD gene

NCBI chr 1:213,562,719...213,572,034
Ensembl chr 1:204,131,501...204,142,823

G

bromo adjacent homology domain containing 1

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of BAHD1 gene

NCBI chr 3:126,341,853...126,368,281
Ensembl chr 3:105,892,478...105,914,410

G

BCL2 associated X, apoptosis regulator

increases expression
affects expression

Ethylnitrosourea results in increased expression of BAX mRNA
Ethylnitrosourea affects the expression of BAX mRNA

PMID:11356909 PMID:15954086 PMID:19100860 PMID:30944280

NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368

G

B-cell receptor-associated protein 31

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of BCAP31 gene

NCBI chr X:156,548,911...156,581,002
Ensembl chr X:151,397,576...151,428,506

G

branched chain amino acid transaminase 2

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of BCAT2 gene

NCBI chr 1:105,175,157...105,196,474
Ensembl chr 1:96,042,625...96,060,007

G

BCL2, apoptosis regulator

increases expression

Ethylnitrosourea results in increased expression of BCL2 mRNA

NCBI chr13:23,204,464...23,366,900
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

Bcl2-like 1

increases expression

Ethylnitrosourea results in increased expression of BCL2L1 mRNA

NCBI chr 3:161,713,777...161,764,844
Ensembl chr 3:141,253,523...141,303,479
Ensembl chr 1:141,253,523...141,303,479

G

brain-derived neurotrophic factor

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of BDNF gene

NCBI chr 3:116,619,633...116,670,212
Ensembl chr 3:96,165,042...96,215,615

G

beclin 1

decreases phosphorylation
multiple interactions

Ethylnitrosourea results in decreased phosphorylation of BECN1 protein
Quercetin inhibits the reaction [Ethylnitrosourea results in decreased phosphorylation of BECN1 protein]

NCBI chr10:86,731,649...86,747,002
Ensembl chr10:86,231,388...86,246,742

G

bone morphogenetic protein 5

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of BMP5 gene

PMID:9475716 PMID:9825669 PMID:10517996

NCBI chr 8:85,397,629...85,520,374
Ensembl chr 8:76,517,164...76,639,925

G

BOP1 ribosomal biogenesis factor

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of BOP1 gene

NCBI chr 7:110,052,716...110,076,529
Ensembl chr 7:108,172,066...108,195,931

G

bromodomain and WD repeat domain containing 1

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of BRWD1 gene

NCBI chr11:48,756,174...48,853,692
Ensembl chr11:35,288,313...35,378,768

G

BTG anti-proliferation factor 2

increases expression

Ethylnitrosourea results in increased expression of BTG2 mRNA

NCBI chr13:48,083,931...48,087,690
Ensembl chr13:45,531,925...45,535,628

G

complement C3

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of C3 mRNA

NCBI chr 9:2,174,412...2,201,339
Ensembl chr 9:2,087,437...2,114,429

G

ciliary associated calcium binding coiled-coil 1

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of CABCOCO1 mRNA

NCBI chr20:20,057,462...20,166,732
Ensembl chr20:20,058,454...20,167,725

G

calcium voltage-gated channel subunit alpha1 A

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of CACNA1A exon; Ethylnitrosourea results in increased mutagenesis of CACNA1A gene

PMID:16724327 PMID:17376154

NCBI chr19:40,425,560...40,724,810
Ensembl chr19:23,520,741...23,823,225

G

calcium voltage-gated channel auxiliary subunit alpha2delta 2

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of CACNA2D2 gene

NCBI chr 8:116,950,860...117,082,159
Ensembl chr 8:108,072,454...108,203,173

G

calcyphosine-like

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of CAPSL exon; Ethylnitrosourea results in increased mutagenesis of CAPSL intron

NCBI chr 2:60,122,162...60,152,692
Ensembl chr 2:58,411,424...58,424,980

G

caspase recruitment domain family, member 11

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of CARD11 gene

NCBI chr12:18,735,088...18,872,045
Ensembl chr12:13,621,087...13,758,112

G

caspase 3

increases cleavage

Ethylnitrosourea results in increased cleavage of CASP3 protein

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648

G

cholecystokinin B receptor

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of CCKBR gene

NCBI chr 1:169,183,578...169,193,583
Ensembl chr 1:159,771,733...159,814,881

G

cyclin D1

increases expression

Ethylnitrosourea results in increased expression of CCND1 mRNA

NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:200,089,002...200,098,602

G

cyclin E2

multiple interactions
decreases expression

DICER1 protein affects the reaction [Ethylnitrosourea results in decreased expression of CCNE2 mRNA]; Ethylnitrosourea affects the reaction [DICER1 protein affects the expression of CCNE2 mRNA]

NCBI chr 5:29,082,169...29,094,879
Ensembl chr 5:24,284,922...24,297,632

G

cyclin G1

increases expression

Ethylnitrosourea results in increased expression of CCNG1 mRNA

PMID:15954086 PMID:19100860

NCBI chr10:25,678,503...25,684,876
Ensembl chr10:25,176,234...25,181,641

G

chaperonin containing TCP1 subunit 8

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of CCT8 mRNA

NCBI chr11:40,196,619...40,208,328
Ensembl chr11:26,710,370...26,722,079

G

CD302 molecule

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of CD302 intron

NCBI chr 3:65,131,017...65,164,737
Ensembl chr 3:44,722,325...44,756,045

G

CD36 molecule

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of CD36 gene

PMID:15690042 PMID:16724327

NCBI chr 4:18,209,088...18,302,142
Ensembl chr 4:17,354,466...17,513,903

G

Cd4 molecule

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of CD4 intron

NCBI chr 4:159,355,147...159,381,636
Ensembl chr 4:157,668,878...157,695,191

G

CD59b molecule

increases mutagenesis
multiple interactions
decreases lipidation

Ethylnitrosourea results in increased mutagenesis of CD59 protein
[Ethylnitrosourea results in increased mutagenesis of and results in decreased activity of PIGA protein] which affects the localization of CD59 protein; [Ethylnitrosourea results in increased mutagenesis of PIGA gene] which results in decreased expression of CD59 protein
Ethylnitrosourea results in decreased lipidation of CD59 protein

PMID:17045307 PMID:19965957 PMID:20202993 PMID:27931811

NCBI chr 3:110,914,008...110,932,489
Ensembl chr 3:90,459,162...90,478,847

G

CD83 molecule

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of CD83 gene

NCBI chr17:21,093,281...21,113,223
Ensembl chr17:20,887,309...20,907,083

G

codanin 1

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of CDAN1 mRNA

NCBI chr 3:128,129,664...128,143,520
Ensembl chr 3:107,673,645...107,689,773

G

cyclin-dependent kinase inhibitor 1A

increases expression
multiple interactions
decreases expression

Ethylnitrosourea results in increased expression of CDKN1A mRNA
DICER1 protein affects the reaction [Ethylnitrosourea results in decreased expression of CDKN1A mRNA]

PMID:15954086 PMID:19100860 PMID:24211769 PMID:24478143

NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,149,217...7,159,585

G

cyclin-dependent kinase inhibitor 2A

increases response to substance
decreases expression
multiple interactions

CDKN2A gene mutant form results in increased susceptibility to Ethylnitrosourea
Ethylnitrosourea results in decreased expression of CDKN2A
Phytic Acid inhibits the reaction [Ethylnitrosourea results in decreased expression of CDKN2A]

PMID:17943659 PMID:21154115

NCBI chr 5:109,100,763...109,114,448
Ensembl chr 5:103,984,949...104,003,149

G

cyclin-dependent kinase inhibitor 2C

decreases expression

Ethylnitrosourea results in decreased expression of CDKN2C protein

NCBI chr 5:129,639,736...129,645,564
Ensembl chr 5:124,411,124...124,416,278

G

cadherin, EGF LAG seven-pass G-type receptor 1

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of CELSR1 gene

NCBI chr 7:118,867,450...119,004,859
Ensembl chr 7:116,987,605...117,125,164

G

centrosomal protein 104

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of CEP104 gene

NCBI chr 5:169,817,383...169,849,681
Ensembl chr 5:164,534,782...164,567,248

G

centrosomal protein 95

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of CEP95 mRNA

NCBI chr10:92,231,829...92,259,813
Ensembl chr10:91,732,111...91,760,092

G

chromodomain helicase DNA binding protein 9

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of CHD9 mRNA

NCBI chr19:32,114,379...32,337,488
Ensembl chr19:15,942,687...16,164,556

G

checkpoint kinase 2

decreases expression

Ethylnitrosourea results in decreased expression of CHEK2 protein

NCBI chr12:51,448,838...51,481,159
Ensembl chr12:45,788,827...45,821,286

G

chromogranin B

increases expression

Ethylnitrosourea results in increased expression of CHGB mRNA

NCBI chr 3:140,496,712...140,510,057
Ensembl chr 3:120,043,738...120,057,166

G

cholinergic receptor, muscarinic 5

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of CHRM5 gene

NCBI chr 3:119,739,229...119,791,630
Ensembl chr 3:99,284,846...99,337,252

G

cholinergic receptor nicotinic alpha 6 subunit

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of CHRNA6 gene

NCBI chr16:71,400,615...71,407,315
Ensembl chr16:64,697,741...64,704,441

G

cholinergic receptor nicotinic delta subunit

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of CHRND gene

NCBI chr 9:95,310,316...95,318,734
Ensembl chr 9:87,862,407...87,870,833

G

carbohydrate sulfotransferase 14

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of CHST14 intron; Ethylnitrosourea results in increased mutagenesis of CHST14 mRNA

NCBI chr 3:126,370,348...126,372,405
Ensembl chr 3:105,916,466...105,918,548

G

collagen type I alpha 2 chain

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of COL1A2 intron

NCBI chr 4:33,518,557...33,553,484
Ensembl chr 4:32,563,381...32,598,867

G

collagen type IV alpha 1 chain

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of COL4A1 gene

NCBI chr16:84,885,597...84,996,482
Ensembl chr16:78,183,533...78,294,412

G

collagen type VI alpha 3 chain

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of COL6A3 mRNA

NCBI chr 9:98,809,171...98,887,060
Ensembl chr 9:91,361,583...91,439,471

G

COMM domain containing 4

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of COMMD4 gene

NCBI chr 8:66,462,188...66,465,700
Ensembl chr 8:57,566,236...57,569,760

G

cytochrome c oxidase copper chaperone COX11

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of COX11 mRNA

NCBI chr10:75,955,825...75,962,398
Ensembl chr10:75,458,749...75,465,322

G

carboxypeptidase N subunit 1

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of CPN1 mRNA

NCBI chr 1:252,793,786...252,822,675
Ensembl chr 1:242,844,212...242,873,465

G

crystallin, alpha A

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of CRYAA gene

NCBI chr20:9,784,872...9,788,656
Ensembl chr20:9,783,605...9,787,349

G

crystallin beta-gamma domain containing 2

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of CRYBG2 intron

NCBI chr 5:151,570,154...151,602,164
Ensembl chr 5:146,286,925...146,323,666

G

crystallin, gamma B

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of CRYGB exon

NCBI chr 9:73,955,204...73,957,264
Ensembl chr 9:66,461,460...66,463,520

G

catenin alpha 1

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of CTNNA1 intron

NCBI chr18:27,002,330...27,135,009
Ensembl chr18:26,728,485...26,860,910

G

chymotrypsin-like

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of CTRB1 intron

NCBI chr19:50,737,078...50,740,659
Ensembl chr19:33,827,229...33,833,626

G

cut-like homeobox 2

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of CUX2 intron

NCBI chr12:40,168,402...40,368,303
Ensembl chr12:34,520,959...34,705,806

G

cytochrome P450, family 17, subfamily a, polypeptide 1

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of CYP17A1 mRNA

NCBI chr 1:255,476,861...255,484,547
Ensembl chr 1:245,535,462...245,541,573

G

cytochrome P450, family 46, subfamily a, polypeptide 1

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of CYP46A1 mRNA

NCBI chr 6:133,011,948...133,039,167
Ensembl chr 6:127,243,315...127,274,760

G

cysteinyl leukotriene receptor 2

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of CYSLTR2 gene

NCBI chr15:54,599,043...54,638,314
Ensembl chr15:48,189,073...48,304,136

G

DALR anticodon binding domain containing 3

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of DALRD3 mRNA

NCBI chr 8:118,142,009...118,147,082
Ensembl chr 8:109,265,676...109,268,568

G

dopamine beta-hydroxylase

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of DBH gene

NCBI chr 3:30,886,313...30,903,313
Ensembl chr 3:10,488,260...10,505,248

G

discoidin, CUB and LCCL domain containing 2

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of DCBLD2 gene

NCBI chr11:55,594,691...55,649,113
Ensembl chr11:42,125,787...42,179,697

G

dachsous cadherin-related 1

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of DCHS1 mRNA

NCBI chr 1:169,516,758...169,550,789
Ensembl chr 1:160,104,931...160,124,808

G

DNA cross-link repair 1B

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of DCLRE1B mRNA

NCBI chr 2:193,998,350...194,006,873
Ensembl chr 2:191,309,913...191,318,423

G

decapping mRNA 1B

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of DCP1B mRNA

NCBI chr 4:154,030,181...154,068,038
Ensembl chr 4:152,358,241...152,397,145

G

DEAD-box helicase 5

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of DDX5 gene

NCBI chr10:92,224,393...92,231,928
Ensembl chr10:91,723,508...91,732,283

G

DEP domain containing 1B

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of DEPDC1B intron

NCBI chr 2:41,605,686...41,697,207
Ensembl chr 2:39,891,481...39,963,779

G

derlin 3

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of DERL3 mRNA

NCBI chr20:12,753,926...12,766,478
Ensembl chr20:12,763,543...12,767,027

G

DNA fragmentation factor subunit beta

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of DFFB intron

NCBI chr 5:169,804,873...169,817,157
Ensembl chr 5:164,522,463...164,534,628

G

DEAH-box helicase 37

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of DHX37 mRNA

NCBI chr12:36,856,119...36,876,245
Ensembl chr12:31,194,859...31,216,802

G

DEAH-box helicase 38

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of DHX38 mRNA

NCBI chr19:54,422,418...54,439,434
Ensembl chr19:37,512,891...37,530,140

G

dicer 1 ribonuclease III

multiple interactions

DICER1 protein affects the reaction [Ethylnitrosourea results in decreased expression of CCNE2 mRNA]; DICER1 protein affects the reaction [Ethylnitrosourea results in decreased expression of CDKN1A mRNA]; DICER1 protein affects the reaction [Ethylnitrosourea results in decreased expression of GADD45B mRNA]; DICER1 protein affects the reaction [Ethylnitrosourea results in decreased expression of JUN mRNA]; Ethylnitrosourea affects the reaction [DICER1 protein affects the expression of CCNE2 mRNA]

NCBI chr 6:129,392,298...129,457,252
Ensembl chr 6:123,631,250...123,693,965

G

disco-interacting protein 2 homolog A

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of DIP2A intron

NCBI chr20:12,284,037...12,373,519
Ensembl chr20:12,284,654...12,370,217

G

dispatched RND transporter family member 1

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of DISP1 gene

PMID:15755804 PMID:16724327

NCBI chr13:97,252,574...97,398,329
Ensembl chr13:94,720,928...94,866,702

G

dystrophin

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of DMD gene

NCBI chr X:51,070,098...53,437,845
Ensembl chr X:47,272,331...49,504,207

G

dynein, axonemal, heavy chain 5

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of DNAH5 mRNA

NCBI chr 2:80,668,182...80,985,918
Ensembl chr 2:78,937,800...79,254,890

G

DnaJ heat shock protein family (Hsp40) member C2

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of DNAJC2 gene

NCBI chr 4:14,162,490...14,189,662
Ensembl chr 4:13,270,191...13,297,431

G

dynamin 3

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of DNM3 gene

NCBI chr13:76,892,381...77,371,346
Ensembl chr13:74,359,213...74,838,108

G

DNA methyltransferase 1

increases expression

Ethylnitrosourea results in increased expression of DNMT1

NCBI chr 8:27,716,797...27,763,405
Ensembl chr 8:19,440,611...19,486,659

G

dopamine receptor D1

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of DRD1 gene

NCBI chr17:10,545,488...10,550,029
Ensembl chr17:10,540,558...10,545,002

G

DS cell adhesion molecule

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of DSCAM mRNA

NCBI chr11:49,391,385...49,976,861
Ensembl chr11:35,926,896...36,507,415

G

dystonin

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of DST gene

NCBI chr 9:43,631,716...44,025,535
Ensembl chr 9:36,135,284...36,529,615

G

deltex E3 ubiquitin ligase 3L

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of DTX3L mRNA

NCBI chr11:78,320,225...78,329,837
Ensembl chr11:64,814,926...64,824,538

G

dishevelled segment polarity protein 3

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of DVL3 mRNA

NCBI chr11:93,869,834...93,887,013
Ensembl chr11:80,366,117...80,382,462

G

dynein cytoplasmic 1 heavy chain 1

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of DYNC1H1 gene

NCBI chr 6:135,436,375...135,502,117
Ensembl chr 6:129,609,397...129,680,883

G

dynein cytoplasmic 2 heavy chain 1

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of DYNC2H1 gene

NCBI chr 8:12,473,955...12,697,075
Ensembl chr 8:4,189,257...4,412,183

G

endothelin 3

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of EDN3 exon

NCBI chr 3:183,980,458...184,004,958
Ensembl chr 3:163,562,520...163,585,093

G

endothelin receptor type B

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of EDNRB gene

PMID:9475716 PMID:17174358

NCBI chr15:87,055,490...87,086,765
Ensembl chr15:80,643,043...80,672,115

G

epidermal growth factor receptor

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of EGFR gene

PMID:15366372 PMID:16724327

NCBI chr14:95,378,626...95,551,358
Ensembl chr14:91,177,067...91,344,382

G

eukaryotic translation initiation factor 3, subunit J

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of EIF3J gene

NCBI chr 3:129,438,715...129,460,953
Ensembl chr 3:108,985,118...109,007,953

G

empty spiracles homeobox 2

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of EMX2 gene

NCBI chr 1:268,612,663...268,619,671
Ensembl chr 1:258,626,584...258,633,594

G

enamelin

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of ENAM exon; Ethylnitrosourea results in increased mutagenesis of ENAM intron

PMID:15649948 PMID:17652207

NCBI chr14:19,840,773...19,865,476
Ensembl chr14:19,556,729...19,581,425

G

erythrocyte membrane protein band 4.1 like 5

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of EPB41L5 gene

NCBI chr13:33,221,705...33,321,400
Ensembl chr13:30,669,764...30,768,360

G

epoxide hydrolase 1

increases expression

Ethylnitrosourea results in increased expression of EPHX1 mRNA

NCBI chr13:95,246,079...95,275,852
Ensembl chr13:92,714,315...92,790,235

G

erb-b2 receptor tyrosine kinase 2

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of ERBB2 gene

NCBI chr10:83,907,491...83,931,365
Ensembl chr10:83,411,313...83,435,078

G

exosome component 5

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of EXOSC5 gene

NCBI chr 1:90,295,495...90,305,047
Ensembl chr 1:81,166,023...81,177,265

G

fumarylacetoacetate hydrolase

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of FAH gene

PMID:16180137 PMID:16724327

NCBI chr 1:147,957,931...147,980,708
Ensembl chr 1:138,548,834...138,571,505

G

family with sequence similarity 216, member A

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of FAM216A gene

NCBI chr12:39,859,307...39,868,450
Ensembl chr12:34,198,526...34,207,665

G

family with sequence similarity 98, member A

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of FAM98A mRNA

NCBI chr 6:25,626,108...25,640,767
Ensembl chr 6:19,874,071...19,888,742

G

FA complementation group C

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of FANCC mRNA

NCBI chr17:1,686,374...1,818,672
Ensembl chr17:1,681,324...1,829,376

G

FAT atypical cadherin 2

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of FAT2 mRNA

NCBI chr10:39,864,765...39,957,027
Ensembl chr10:39,364,073...39,456,216

G

farnesyl diphosphate farnesyl transferase 1

decreases expression

Ethylnitrosourea results in decreased expression of FDFT1 mRNA

NCBI chr15:41,588,114...41,616,168
Ensembl chr15:37,412,146...37,440,287

G

ferrochelatase

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of FECH gene

NCBI chr18:60,215,325...60,248,525
Ensembl chr18:57,945,122...57,979,348

G

formin 2

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of FMN2 mRNA

NCBI chr13:88,986,863...89,303,789
Ensembl chr13:86,453,926...86,771,411

G

Fos proto-oncogene, AP-1 transcription factor subunit

increases expression

Ethylnitrosourea results in increased expression of FOS mRNA

NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:105,121,170...105,124,036

G

forkhead box F2

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of FOXF2 gene

NCBI chr17:33,044,446...33,051,259
Ensembl chr17:32,836,777...32,842,176

G

forkhead box N1

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of FOXN1 gene

NCBI chr10:63,749,461...63,778,468
Ensembl chr10:63,251,400...63,273,710

G

forkhead box O1

increases expression

Ethylnitrosourea results in increased expression of FOXO1 protein

NCBI chr 2:138,462,974...138,541,420
Ensembl chr 2:136,312,168...136,387,790

G

Fras1 related extracellular matrix 1

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of FREM1 gene

NCBI chr 5:102,367,201...102,515,464
Ensembl chr 5:97,322,538...97,469,543

G

FRY like transcription coactivator

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of FRYL mRNA

NCBI chr14:34,956,623...35,189,738
Ensembl chr14:34,956,620...35,190,222

G

follicle stimulating hormone receptor

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of FSHR gene

NCBI chr 6:10,952,329...11,160,288
Ensembl chr 6:5,198,825...5,406,785

G

growth arrest and DNA-damage-inducible, beta

increases expression
multiple interactions
decreases expression

Ethylnitrosourea results in increased expression of GADD45B mRNA
DICER1 protein affects the reaction [Ethylnitrosourea results in decreased expression of GADD45B mRNA]

PMID:19100860 PMID:24478143

NCBI chr 7:9,428,689...9,430,991
Ensembl chr 7:8,778,007...8,780,046

G

galactose-3-O-sulfotransferase 3

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of GAL3ST3 gene

NCBI chr 1:212,022,989...212,032,802
Ensembl chr 1:202,593,692...202,603,445

G

GATA binding protein 1

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of GATA1 gene

NCBI chr X:17,193,291...17,209,462
Ensembl chr X:14,529,702...14,537,530

G

GATA binding protein 6

multiple interactions
increases activity

Ethylnitrosourea promotes the reaction [GATA6 protein binds to KRAS exon]
Ethylnitrosourea results in increased activity of GATA6 protein

NCBI chr18:2,460,909...2,492,322
Ensembl chr18:2,188,121...2,219,532

G

glucokinase

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of GCK exon; Ethylnitrosourea results in increased mutagenesis of GCK gene

PMID:15102714 PMID:15161764 PMID:16724327 PMID:18056790

NCBI chr14:84,999,019...85,041,098
Ensembl chr14:80,785,060...80,826,995

G

glial cells missing transcription factor 2

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of GCM2 mRNA

NCBI chr17:23,858,379...23,867,495
Ensembl chr17:23,652,637...23,661,754

G

growth differentiation factor 15

increases expression

Ethylnitrosourea results in increased expression of GDF15 mRNA

NCBI chr16:18,838,436...18,842,022
Ensembl chr16:18,805,239...18,808,055

G

growth factor independent 1 transcriptional repressor

decreases expression

Ethylnitrosourea results in decreased expression of GFI1 protein

NCBI chr14:2,185,489...2,204,191
Ensembl chr14:2,042,434...2,051,814

G

gamma-glutamyltransferase 1

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of GGT1 gene

NCBI chr20:13,074,141...13,103,551
Ensembl chr20:13,074,700...13,108,442

G

gap junction protein, alpha 1

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of GJA1 exon; Ethylnitrosourea results in increased mutagenesis of GJA1 gene

PMID:15548583 PMID:16155213 PMID:16724327

NCBI chr20:36,302,490...36,315,010
Ensembl chr20:35,755,991...35,768,582

G

gap junction protein, alpha 8

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of GJA8 gene

NCBI chr 2:187,179,668...187,181,284
Ensembl chr 2:184,490,840...184,492,456

G

gap junction protein, beta 1

multiple interactions

[Ethylnitrosourea co-treated with chlorendic acid] results in decreased expression of GJB1 protein; [Ethylnitrosourea co-treated with ciprofibrate] results in decreased expression of GJB1 protein; [Ethylnitrosourea co-treated with Dioxins] results in decreased expression of GJB1 protein; [Ethylnitrosourea co-treated with Phenobarbital] results in decreased expression of GJB1 protein; [Ethylnitrosourea co-treated with pirinixic acid] results in decreased expression of GJB1 protein; [Ethylnitrosourea co-treated with Tamoxifen] results in decreased expression of GJB1 protein

NCBI chr X:70,541,845...70,549,776
Ensembl chr X:66,501,820...66,509,925

G

gap junction protein, beta 2

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of GJB2 gene

NCBI chr15:35,375,977...35,393,817
Ensembl chr15:31,260,357...31,278,177

G

GLI family zinc finger 1

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of GLI1 mRNA

NCBI chr 7:65,042,237...65,054,888
Ensembl chr 7:63,156,926...63,169,251

G

GLI family zinc finger 3

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of GLI3 gene

NCBI chr17:54,134,064...54,405,198
Ensembl chr17:49,438,567...49,709,712

G

glycine receptor, alpha 1

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of GLRA1 exon

NCBI chr10:40,128,284...40,228,612
Ensembl chr10:39,629,459...39,727,162

G

G protein subunit alpha 11

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of GNA11 gene

NCBI chr 7:8,814,285...8,828,628
Ensembl chr 7:8,162,750...8,179,812

G

G protein subunit alpha q

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of GNAQ gene

NCBI chr 1:222,852,453...223,098,754
Ensembl chr 1:213,424,465...213,667,672

G

GNAS complex locus

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of GNAS gene

NCBI chr 3:183,489,648...183,554,570
Ensembl chr 3:163,071,417...163,127,262
Ensembl chr 3:163,071,417...163,127,262

G

N-acetylglucosamine-1-phosphate transferase subunit gamma

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of GNPTG intron

NCBI chr10:14,756,685...14,761,636
Ensembl chr10:14,251,136...14,257,096

G

gonadotropin releasing hormone receptor

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of GNRHR gene

NCBI chr14:22,211,666...22,229,654
Ensembl chr14:21,856,871...21,874,861

G

G patch domain containing 2

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of GPATCH2 mRNA

NCBI chr13:101,316,413...101,457,109
Ensembl chr13:98,784,969...98,925,661

G

G patch domain and KOW motifs

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of GPKOW mRNA

NCBI chr X:17,463,521...17,478,298
Ensembl chr X:14,791,610...14,806,384

G

G protein-coupled receptor 137

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of GPR137 intron

NCBI chr 1:213,558,846...213,562,422
Ensembl chr 1:204,129,636...204,133,082

G

G protein-coupled receptor 153

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of GPR153 gene

NCBI chr 5:168,064,134...168,075,697
Ensembl chr 5:162,781,587...162,792,971

G

G protein-coupled receptor 33, pseudogene 1

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of GPR33 gene

NCBI chr 6:75,209,776...75,210,781
Ensembl chr 6:69,474,435...69,475,440

G

glutamate ionotropic receptor delta type subunit 2

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of GRID2 gene

NCBI chr 4:93,745,165...95,222,354
Ensembl chr 4:92,415,230...93,889,355

G

glutamate ionotropic receptor kainate type subunit 1

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of GRIK1 gene

NCBI chr11:40,655,974...41,056,966
Ensembl chr11:27,169,740...27,570,645

G

glutamate metabotropic receptor 6

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of GRM6 exon

NCBI chr10:35,669,003...35,683,729
Ensembl chr10:35,167,985...35,182,717

G

glutamate metabotropic receptor 8

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of GRM8 gene

NCBI chr 4:56,771,247...57,696,951
Ensembl chr 4:55,805,955...56,730,831

G

gastrin releasing peptide receptor

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of GRPR gene

NCBI chr X:34,630,238...34,670,245
Ensembl chr X:30,998,416...31,038,442

G

gasdermin E

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of GSDME mRNA

NCBI chr 4:80,590,344...80,651,943
Ensembl chr 4:79,257,804...79,320,806

G

glycogen synthase kinase 3 beta

decreases expression

Ethylnitrosourea results in decreased expression of GSK3B protein

NCBI chr11:76,004,502...76,154,665
Ensembl chr11:62,504,316...62,648,646

G

glutathione S-transferase theta 1

affects response to substance

GSTT1 gene polymorphism affects the susceptibility to Ethylnitrosourea

NCBI chr20:12,856,068...12,873,020
Ensembl chr20:12,856,669...12,873,585

G

H2A.X variant histone

increases phosphorylation

Ethylnitrosourea results in increased phosphorylation of H2AX protein

NCBI chr 8:53,568,718...53,570,072
Ensembl chr 8:44,671,786...44,673,239
Ensembl chr 4:44,671,786...44,673,239

G

hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of HADHB exon

NCBI chr 6:31,873,404...31,907,557
Ensembl chr 6:26,153,578...26,184,869

G

histone deacetylase 1

increases expression

Ethylnitrosourea results in increased expression of HDAC1

NCBI chr 5:147,138,328...147,165,387
Ensembl chr 5:141,853,989...141,881,111

G

HECT domain E3 ubiquitin protein ligase 1

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of HECTD1 gene

NCBI chr 6:74,916,803...75,003,408
Ensembl chr 6:69,181,436...69,268,053

G

hes family bHLH transcription factor 3

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of HES3 mRNA

NCBI chr 5:168,076,337...168,082,270
Ensembl chr 5:162,794,367...162,796,261

G

homeostatic iron regulator

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of HFE mRNA

NCBI chr17:41,841,302...41,849,359
Ensembl chr17:41,413,451...41,421,502

G

heat shock protein nuclear import factor hikeshi

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of HIKESHI gene

NCBI chr 1:153,237,948...153,261,856
Ensembl chr 1:143,825,923...143,849,363

G

hemicentin 2

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of HMCN2 3' UTR; Ethylnitrosourea results in increased mutagenesis of HMCN2 intron; Ethylnitrosourea results in increased mutagenesis of HMCN2 mRNA

NCBI chr 3:34,986,246...35,136,047
Ensembl chr 3:14,588,662...14,738,025

G

3-hydroxy-3-methylglutaryl-CoA synthase 1

decreases expression

Ethylnitrosourea results in decreased expression of HMGCS1 mRNA

NCBI chr 2:53,379,457...53,399,807
Ensembl chr 2:51,649,497...51,667,100

G

heme oxygenase 1

increases expression

Ethylnitrosourea results in increased expression of HMOX1 mRNA

NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,467,244...13,474,079

G

homeo box D12

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of HOXD12 gene

NCBI chr 3:79,985,106...79,986,227
Ensembl chr 3:59,577,677...59,578,798

G

hypoxanthine phosphoribosyltransferase 1

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of HPRT1 gene

PMID:22167886 PMID:32529823

NCBI chr X:137,655,744...137,687,718
Ensembl chr X:132,736,096...132,768,154

G

HR, lysine demethylase and nuclear receptor corepressor

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of HR exon; Ethylnitrosourea results in increased mutagenesis of HR gene

PMID:16455232 PMID:16461637 PMID:16724327

NCBI chr15:52,036,540...52,056,019
Ensembl chr15:45,626,835...45,646,313

G

HRas proto-oncogene, GTPase

increases response to substance

HRAS protein results in increased susceptibility to Ethylnitrosourea

PMID:11182032 PMID:26558449

NCBI chr 1:205,712,625...205,729,406
Ensembl chr 1:196,296,263...196,300,615

G

histidine rich calcium binding protein

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of HRC mRNA

NCBI chr 1:104,949,750...104,953,475
Ensembl chr 1:95,813,253...95,816,984

G

heat shock transcription factor 1

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of HSF1 3' UTR

NCBI chr 7:110,076,710...110,103,665
Ensembl chr 7:108,196,056...108,223,011

G

heat shock protein 90 alpha family class B member 1

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of HSP90AB1 gene

NCBI chr 9:22,930,249...22,935,929
Ensembl chr 9:15,433,691...15,438,488

G

huntingtin

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of HTT gene

NCBI chr14:80,070,456...80,219,668
Ensembl chr14:75,845,836...75,995,070

G

inhibitor of DNA binding 1

increases expression

Ethylnitrosourea results in increased expression of ID1 mRNA

NCBI chr 3:161,671,525...161,672,691
Ensembl chr 3:141,211,267...141,212,419

G

inhibitor of DNA binding 3

increases expression

Ethylnitrosourea results in increased expression of ID3 mRNA

NCBI chr 5:153,656,253...153,657,860
Ensembl chr 5:148,372,762...148,374,349

G

interferon-induced protein 35

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of IFI35 gene

NCBI chr10:86,881,270...86,889,523
Ensembl chr10:86,381,010...86,389,952

G

intraflagellar transport 172

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of IFT172 gene

NCBI chr 6:30,801,841...30,841,239
Ensembl chr 6:25,081,980...25,120,860

G

intraflagellar transport 88

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of IFT88 gene

PMID:15755804 PMID:16724327

NCBI chr15:35,685,678...35,786,875
Ensembl chr15:31,573,376...31,672,147

G

insulin-like growth factor 1 receptor

increases mutagenesis
increases phosphorylation

Ethylnitrosourea results in increased mutagenesis of IGF1R gene
Ethylnitrosourea results in increased phosphorylation of IGF1R protein

PMID:16461637 PMID:32902906

NCBI chr 1:130,959,787...131,248,664
Ensembl chr 1:121,550,743...121,831,777

G

IKAROS family zinc finger 1

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of IKZF1 gene

NCBI chr14:90,468,696...90,556,522
Ensembl chr14:86,255,065...86,342,416

G

interleukin 7

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of IL7 exon

PMID:17151827 PMID:17179092

NCBI chr 2:96,142,523...96,186,282
Ensembl chr 2:94,234,766...94,280,075

G

internexin neuronal intermediate filament protein, alpha

increases expression

Ethylnitrosourea results in increased expression of INA mRNA

NCBI chr 1:255,838,129...255,849,680
Ensembl chr 1:245,896,775...245,908,330

G

inositol polyphosphate-5-phosphatase D

decreases expression

Ethylnitrosourea results in decreased expression of INPP5D protein

NCBI chr 9:95,735,533...95,840,584
Ensembl chr 9:88,287,677...88,392,746

G

insulin 2

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of INS2 gene

NCBI chr 1:207,272,738...207,421,998
Ensembl chr 1:197,843,281...197,864,775

G

insulin induced gene 1

decreases expression

Ethylnitrosourea results in decreased expression of INSIG1 mRNA

NCBI chr 4:8,049,339...8,057,812
Ensembl chr 4:7,315,495...7,323,952

G

insulin receptor

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of INSR gene

NCBI chr12:5,991,135...6,129,275
Ensembl chr12:1,197,100...1,330,883

G

IQ motif containing K

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of IQCK mRNA

NCBI chr 1:182,630,678...182,748,325
Ensembl chr 1:173,199,316...173,316,984

G

iroquois homeobox 6

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of IRX6 mRNA

NCBI chr19:30,503,416...30,509,396
Ensembl chr19:14,330,440...14,336,403

G

inositol-trisphosphate 3-kinase B

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of ITPKB gene

NCBI chr13:94,601,072...94,696,180
Ensembl chr13:92,069,216...92,162,004

G

jagged canonical Notch ligand 1

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of JAG1 gene

NCBI chr 3:144,859,453...144,894,883
Ensembl chr 3:124,406,794...124,442,209

G

Janus kinase 1

increases phosphorylation

Ethylnitrosourea results in increased phosphorylation of JAK1 protein

NCBI chr 5:120,895,606...121,004,207
Ensembl chr 5:115,780,248...115,888,926

G

Janus kinase 3

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of JAK3 gene

NCBI chr16:18,418,807...18,432,515
Ensembl chr16:18,386,405...18,398,536

G

joining chain of multimeric IgA and IgM

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of JCHAIN gene

NCBI chr14:19,822,976...19,831,072
Ensembl chr14:19,538,952...19,546,298

G

Jun proto-oncogene, AP-1 transcription factor subunit

increases expression
multiple interactions
decreases expression

Ethylnitrosourea results in increased expression of JUN mRNA
DICER1 protein affects the reaction [Ethylnitrosourea results in decreased expression of JUN mRNA]

PMID:19100860 PMID:24478143

NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:109,893,145...109,897,656

G

potassium voltage-gated channel subfamily A member 2

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of KCNA2 mRNA

NCBI chr 2:197,392,746...197,406,606
Ensembl chr 2:194,704,639...194,718,400

G

potassium voltage-gated channel subfamily E regulatory subunit 1

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of KCNE1 gene

NCBI chr11:45,066,875...45,080,024
Ensembl chr11:31,580,742...31,593,901

G

potassium voltage-gated channel subfamily H member 3

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of KCNH3 gene

NCBI chr 7:132,244,492...132,262,725
Ensembl chr 7:130,366,011...130,383,855

G

potassium inwardly-rectifying channel, subfamily J, member 11

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of KCNJ11 gene

NCBI chr 1:105,727,473...105,731,167
Ensembl chr 1:96,591,049...96,594,082

G

potassium inwardly-rectifying channel, subfamily J, member 8

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of KCNJ8 gene

NCBI chr 4:177,240,692...177,246,548
Ensembl chr 4:175,508,912...175,515,603

G

potassium two pore domain channel subfamily K member 4

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of KCNK4 gene

NCBI chr 1:213,547,577...213,558,706
Ensembl chr 1:204,114,572...204,125,925

G

potassium voltage-gated channel subfamily Q member 1

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of KCNQ1 gene

NCBI chr 1:207,721,134...208,054,073
Ensembl chr 1:198,291,766...198,624,669

G

potassium voltage-gated channel subfamily Q member 2

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of KCNQ2 exon

NCBI chr 3:188,572,345...188,631,391
Ensembl chr 3:168,195,357...168,275,071

G

kinase insert domain receptor

increases expression

Ethylnitrosourea results in increased expression of KDR protein

NCBI chr14:32,572,031...32,615,204
Ensembl chr14:32,217,871...32,261,018

G

kinesin family member 3a

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of KIF3A gene

PMID:15755804 PMID:16724327

NCBI chr10:38,226,388...38,263,062
Ensembl chr10:37,725,970...37,759,191

G

KISS1 receptor

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of KISS1R gene

NCBI chr 7:10,435,766...10,439,424
Ensembl chr 7:9,785,135...9,788,793

G

KIT proto-oncogene receptor tyrosine kinase

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of KIT exon; Ethylnitrosourea results in increased mutagenesis of KIT gene

PMID:15731517 PMID:15820307

NCBI chr14:32,901,615...32,978,895
Ensembl chr14:32,548,877...32,624,652

G

kallikrein related-peptidase 8

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of KLK8 mRNA

NCBI chr 1:103,388,352...103,395,195
Ensembl chr 1:94,251,803...94,258,646

G

lysine methyltransferase 2B

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of KMT2B gene

NCBI chr 1:94,949,144...94,969,239
Ensembl chr 1:85,821,753...85,841,326

G

KRAS proto-oncogene, GTPase

multiple interactions
increases mutagenesis

Ethylnitrosourea promotes the reaction [GATA6 protein binds to KRAS exon]; Ethylnitrosourea promotes the reaction [NFYA protein binds to KRAS exon]
Ethylnitrosourea results in increased mutagenesis of KRAS gene

PMID:15790496 PMID:16271038

NCBI chr 4:179,916,255...179,949,613

G

keratin 35

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of KRT35 mRNA

NCBI chr10:85,026,171...85,029,568
Ensembl chr10:85,026,171...85,029,568

G

keratin 71

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of KRT71 gene

NCBI chr 7:134,752,240...134,778,765
Ensembl chr 7:132,873,540...132,882,325

G

keratin associated protein 5-1

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of KRTAP5-3 mRNA

NCBI chr 1:206,708,389...206,709,396

G

laminin subunit alpha 2

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of LAMA2 gene

NCBI chr 1:19,492,126...20,140,056
Ensembl chr 1:17,672,536...18,320,530

G

laminin subunit beta 3

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of LAMB3 mRNA

NCBI chr13:107,362,514...107,404,081
Ensembl chr13:104,833,873...104,875,405

G

laminin subunit gamma 2

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of LAMC2 intron

NCBI chr13:67,835,199...67,894,694
Ensembl chr13:65,284,664...65,344,200

G

LARGE xylosyl- and glucuronyltransferase 1

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of LARGE1 gene

NCBI chr19:11,609,004...12,057,174
Ensembl chr19:11,603,129...12,048,930

G

lactate dehydrogenase A

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of LDHA exon; Ethylnitrosourea results in increased mutagenesis of LDHA gene

PMID:7534515 PMID:16180137

NCBI chr 1:106,508,092...106,517,512
Ensembl chr 1:97,366,021...97,433,472

G

leptin receptor

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of LEPR gene

NCBI chr 5:121,409,735...121,593,201
Ensembl chr 5:116,289,823...116,475,908

G

galectin 3

increases expression

Ethylnitrosourea results in increased expression of LGALS3 mRNA

NCBI chr15:23,099,795...23,111,731
Ensembl chr15:20,607,692...20,632,025

G

luteinizing hormone/choriogonadotropin receptor

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of LHCGR gene

NCBI chr 6:11,415,361...11,480,834
Ensembl chr 6:5,661,871...5,724,521

G

LIM homeobox 2

decreases expression

Ethylnitrosourea results in decreased expression of LHX2 mRNA

NCBI chr 3:42,523,345...42,553,646
Ensembl chr 3:22,126,007...22,143,908

G

LIM homeobox 4

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of LHX4 mRNA

NCBI chr13:70,423,768...70,477,337
Ensembl chr13:67,877,109...67,927,003

G

LIF, interleukin 6 family cytokine

increases expression

Ethylnitrosourea results in increased expression of LIF mRNA

NCBI chr14:83,354,602...83,364,053
Ensembl chr14:79,134,574...79,140,482

G

limb development membrane protein 1

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of LMBR1 intron

NCBI chr 4:6,649,824...6,820,525
Ensembl chr 4:5,974,750...6,146,368

G

ligand of numb-protein X 2

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of LNX2 mRNA

NCBI chr12:8,005,202...8,070,494
Ensembl chr12:8,005,227...8,070,494

G

lysophosphatidic acid receptor 3

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of LPAR3 mRNA

NCBI chr 2:237,785,371...237,854,199
Ensembl chr 2:235,149,065...235,193,357

G

LDL receptor related protein 2

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of LRP2 mRNA

NCBI chr 3:74,597,148...74,754,535
Ensembl chr 3:54,189,308...54,346,708

G

LDL receptor related protein 5

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of LRP5 gene

NCBI chr 1:210,243,499...210,346,886
Ensembl chr 1:200,814,250...200,917,581

G

LDL receptor related protein 8

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of LRP8 mRNA

NCBI chr 5:127,792,236...127,864,207
Ensembl chr 5:122,563,453...122,631,352

G

leucine rich repeat containing 14

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of LRRC14 mRNA

NCBI chr 7:110,311,384...110,317,757
Ensembl chr 7:108,430,792...108,437,111

G

LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of LSM3 3' UTR; Ethylnitrosourea results in increased mutagenesis of LSM3 gene

NCBI chr 4:125,578,185...125,584,429
Ensembl chr 4:124,021,023...124,027,269

G

lymphotoxin alpha

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of LTA gene

NCBI chr20:3,622,291...3,625,852
Ensembl chr20:3,618,853...3,620,859

G

lumican

increases expression

Ethylnitrosourea results in increased expression of LUM mRNA

NCBI chr 7:34,245,323...34,252,510
Ensembl chr 7:32,358,614...32,365,793

G

latexin

increases expression

Ethylnitrosourea results in increased expression of LXN mRNA

NCBI chr 2:154,037,604...154,043,473
Ensembl chr 2:151,727,102...151,733,460

G

lymphocyte antigen 9

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of LY9 mRNA

NCBI chr13:86,610,762...86,633,314
Ensembl chr13:84,079,458...84,100,823

G

Ly6/Plaur domain containing 2

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of LYPD2 mRNA

NCBI chr 7:108,506,545...108,508,582
Ensembl chr 7:106,617,561...106,619,598

G

MAP-kinase activating death domain

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of MADD mRNA

NCBI chr 3:97,570,141...97,613,688
Ensembl chr 3:77,114,314...77,157,701

G

mannosidase, alpha, class 2C, member 1

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of MAN2C1 gene

NCBI chr 8:66,434,480...66,445,649
Ensembl chr 8:57,537,321...57,549,690

G

mitogen-activated protein kinase 6

increases expression

Ethylnitrosourea results in increased expression of MAPK6 mRNA

NCBI chr 8:85,027,141...85,050,236
Ensembl chr 8:76,146,690...76,169,720

G

methyl-CpG binding domain protein 1

increases expression

Ethylnitrosourea results in increased expression of MBD1; Ethylnitrosourea results in increased expression of MBD1 mRNA

PMID:19100860 PMID:21154115

NCBI chr18:70,145,093...70,159,744
Ensembl chr18:67,869,992...67,886,554

G

melanocortin 1 receptor

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of MC1R exon; Ethylnitrosourea results in increased mutagenesis of MC1R promoter

NCBI chr19:68,360,950...68,363,877
Ensembl chr19:51,453,239...51,454,192

G

melanocortin 3 receptor

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of MC3R gene

NCBI chr 3:181,434,776...181,435,873
Ensembl chr 3:161,016,347...161,017,444

G

melanocortin 4 receptor

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of MC4R gene

PMID:16720677 PMID:17143585

NCBI chr18:62,689,798...62,691,685
Ensembl chr18:60,419,832...60,421,719

G

minichromosome maintenance complex component 3 associated protein

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of MCM3AP gene

NCBI chr20:12,127,060...12,164,651
Ensembl chr20:12,127,570...12,165,165

G

microspherule protein 1

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of MCRS1 intron

NCBI chr 7:132,262,719...132,271,533
Ensembl chr 7:130,383,853...130,392,685

G

MDM2 proto-oncogene

increases expression

Ethylnitrosourea results in increased expression of MDM2 mRNA

PMID:15954086 PMID:19100860

NCBI chr 7:55,176,558...55,201,757
Ensembl chr 7:53,290,664...53,314,915

G

methyl CpG binding protein 2

increases expression

Ethylnitrosourea results in increased expression of MECP2

NCBI chr X:156,932,481...156,995,981
Ensembl chr X:151,789,930...151,844,689

G

mediator complex subunit 12L

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of MED12L mRNA

NCBI chr 2:145,403,318...145,726,317
Ensembl chr 2:143,252,139...143,573,741

G

methyltransferase like 24

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of METTL24 mRNA

NCBI chr20:45,724,506...45,847,300
Ensembl chr20:44,142,396...44,261,310

G

major facilitator superfamily domain containing 3

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of MFSD3 gene

NCBI chr 7:110,300,254...110,304,108
Ensembl chr 7:108,421,350...108,423,461

G

major facilitator superfamily domain containing 4B1

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of MFSD4B1 mRNA

NCBI chr20:44,991,384...45,004,590
Ensembl chr20:43,436,857...43,450,064

G

alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

increases expression

Ethylnitrosourea results in increased expression of MGAT2 mRNA

NCBI chr 6:93,392,416...93,394,905
Ensembl chr 6:87,656,349...87,658,177

G

alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of MGAT5B intron

NCBI chr10:102,619,559...102,689,023
Ensembl chr10:102,120,445...102,190,233

G

O-6-methylguanine-DNA methyltransferase

increases alkylation
increases expression

Ethylnitrosourea results in increased alkylation of MGMT protein
Ethylnitrosourea results in increased expression of MGMT mRNA

PMID:8823159 PMID:11599795 PMID:15954086

NCBI chr 1:201,140,832...201,367,481
Ensembl chr 1:191,710,930...191,937,756

G

microRNA 22

increases expression

Ethylnitrosourea results in increased expression of MIR22 mRNA

NCBI chr10:60,805,331...60,805,425
Ensembl chr10:60,307,039...60,307,133

G

microRNA 34a

increases expression

Ethylnitrosourea results in increased expression of MIR34A mRNA

NCBI chr 5:165,815,952...165,816,053
Ensembl chr 5:160,533,002...160,533,103

G

microRNA 409

increases expression

Ethylnitrosourea results in increased expression of MIR409 mRNA

NCBI chr 6:134,579,185...134,579,261
Ensembl chr 6:128,757,779...128,757,858

G

microRNA 425

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of MIR425 gene

NCBI chr 8:118,143,084...118,143,166
Ensembl chr 8:109,264,555...109,264,637

G

microRNA 96

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of MIR96 gene

NCBI chr 4:59,755,841...59,755,946
Ensembl chr 4:58,788,411...58,788,516

G

mutL homolog 1

increases expression
multiple interactions

Ethylnitrosourea results in increased expression of MLH1
Phytic Acid inhibits the reaction [Ethylnitrosourea results in increased expression of MLH1]

NCBI chr 8:120,074,871...120,112,109
Ensembl chr 8:111,196,468...111,233,617

G

myeloperoxidase

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of MPO mRNA

NCBI chr10:73,092,124...73,102,057
Ensembl chr10:72,594,661...72,604,819

G

mutS homolog 2

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of MSH2 gene

NCBI chr 6:12,567,368...12,626,534
Ensembl chr 6:6,813,795...6,872,938

G

mutS homolog 6

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of MSH6 gene

PMID:16495775 PMID:18417481

NCBI chr 6:12,316,190...12,333,505
Ensembl chr 6:6,562,632...6,579,956

G

mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 1

decreases expression

Ethylnitrosourea results in decreased expression of ND1 mRNA

NCBI chr MT:2,740...3,694
Ensembl chr MT:2,740...3,694

G

mechanistic target of rapamycin kinase

increases mutagenesis
decreases expression

Ethylnitrosourea results in increased mutagenesis of MTOR gene
Ethylnitrosourea results in decreased expression of MTOR protein

PMID:15485918 PMID:16724327 PMID:32902906

NCBI chr 5:164,167,985...164,277,438
Ensembl chr 5:158,884,804...158,994,311

G

mucin 4, cell surface associated

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of MUC4 mRNA

NCBI chr11:81,513,321...81,575,200

G

mucin 6, oligomeric mucus/gel-forming

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of MUC6 mRNA

NCBI chr 1:206,155,826...206,194,384
Ensembl chr 1:196,726,807...196,764,842

G

MYB proto-oncogene, transcription factor

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of MYB gene

NCBI chr 1:17,759,309...17,793,306
Ensembl chr 1:15,939,761...15,973,057

G

MYC proto-oncogene, bHLH transcription factor

increases expression

Ethylnitrosourea results in increased expression of MYC mRNA

NCBI chr 7:95,483,105...95,488,031
Ensembl chr 7:93,593,705...93,598,630

G

MYD88, innate immune signal transduction adaptor

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of MYD88 exon

NCBI chr 8:127,952,161...127,956,230
Ensembl chr 8:119,074,437...119,079,415

G

myosin heavy chain 2

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of MYH2 mRNA

NCBI chr10:52,355,739...52,382,235
Ensembl chr10:51,856,738...51,883,236

G

myosin IF

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of MYO1F intron

NCBI chr 7:15,065,530...15,116,087
Ensembl chr 7:14,363,350...14,413,911

G

myosin VA

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of MYO5A gene

PMID:9475716 PMID:9825669 PMID:10517996 PMID:17174358

NCBI chr 8:84,692,524...84,860,564
Ensembl chr 8:75,812,412...75,975,918

G

myosin VI

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of MYO6 gene

NCBI chr 8:89,967,351...90,122,219
Ensembl chr 8:81,087,139...81,239,292

G

myosin VIIA

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of MYO7A gene

NCBI chr 1:161,755,110...161,825,397
Ensembl chr 1:152,344,448...152,414,157

G

myocilin

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of MYOC gene

NCBI chr13:77,509,963...77,520,361
Ensembl chr13:74,976,730...74,987,127

G

myelin regulatory factor-like

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of MYRFL intron

NCBI chr 7:54,289,430...54,406,097
Ensembl chr 7:52,403,650...52,519,907

G

myelin transcription factor 1

decreases expression

Ethylnitrosourea results in decreased expression of MYT1 protein

NCBI chr 3:189,263,569...189,327,844
Ensembl chr 3:168,886,089...168,950,341

G

non-SMC condensin II complex, subunit H2

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of NCAPH2 gene

NCBI chr 7:122,302,550...122,319,570
Ensembl chr 7:120,422,956...120,439,938

G

NCK-associated protein 1

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of NCKAP1 gene

NCBI chr 3:85,824,333...85,898,748
Ensembl chr 3:65,417,453...65,492,217

G

necdin, MAGE family member

decreases expression

Ethylnitrosourea results in decreased expression of NDN protein

NCBI chr 1:125,261,059...125,262,658
Ensembl chr 1:115,849,105...115,850,767

G

nei-like DNA glycosylase 1

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of NEIL1 intron

NCBI chr 8:66,446,106...66,452,844
Ensembl chr 8:57,550,147...57,556,258

G

neuroepithelial cell transforming 1

increases expression

Ethylnitrosourea results in increased expression of NET1 mRNA

NCBI chr17:71,251,145...71,280,345
Ensembl chr17:66,340,728...66,370,441

G

neuralized E3 ubiquitin protein ligase 2

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of NEURL2 mRNA

NCBI chr 3:173,985,996...173,988,717
Ensembl chr 3:153,566,660...153,569,380

G

nuclear factor I X

decreases expression

Ethylnitrosourea results in decreased expression of NFIX mRNA

NCBI chr19:40,259,873...40,356,966
Ensembl chr19:23,355,498...23,448,265

G

nuclear transcription factor Y subunit alpha

multiple interactions
increases activity

Ethylnitrosourea promotes the reaction [NFYA protein binds to KRAS exon]
Ethylnitrosourea results in increased activity of NFYA protein

NCBI chr 9:20,085,067...20,111,521
Ensembl chr 9:12,586,259...12,613,898

G

neuroligin 3

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of NLGN3 gene

NCBI chr X:70,469,251...70,497,380
Ensembl chr X:66,429,458...66,451,876

G

neuromedin U receptor 2

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of NMUR2 gene

NCBI chr10:40,666,824...40,682,679
Ensembl chr10:40,166,226...40,182,078

G

nucleolar protein 9

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of NOL9 intron

NCBI chr 5:167,829,249...167,849,364
Ensembl chr 5:162,546,541...162,566,191

G

nitric oxide synthase 1

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of NOS1 gene

NCBI chr12:44,276,011...44,456,371
Ensembl chr12:38,626,714...38,710,945

G

natriuretic peptide receptor 3

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of NPR3 gene

NCBI chr 2:62,592,557...62,660,497
Ensembl chr 2:60,870,594...60,932,955

G

neuropeptide Y receptor Y2

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of NPY2R gene

NCBI chr 2:170,200,027...170,210,286
Ensembl chr 2:167,903,879...167,905,024

G

neuropeptide Y receptor Y4

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of NPY4R gene

NCBI chr16:9,474,051...9,475,307
Ensembl chr16:9,467,801...9,469,057

G

nuclear receptor subfamily 0, group B, member 2

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of NR0B2 gene

NCBI chr 5:151,063,160...151,066,475
Ensembl chr 5:145,779,294...145,782,609

G

nuclear receptor subfamily 1, group D, member 1

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of NR1D1 gene

NCBI chr10:84,224,599...84,231,812
Ensembl chr10:83,728,318...83,735,705

G

NOP2/Sun RNA methyltransferase family member 7

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of NSUN7 gene

NCBI chr14:42,233,062...42,289,013
Ensembl chr14:41,879,293...41,934,949

G

neurotrophic receptor tyrosine kinase 2

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of NTRK2 gene

NCBI chr17:5,560,558...5,875,899
Ensembl chr17:5,559,043...5,869,136

G

neurotensin

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of NTS gene

NCBI chr 7:39,451,484...39,460,888
Ensembl chr 7:37,564,533...37,574,423

G

nucleoporin 133

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of NUP133 gene

NCBI chr19:68,789,065...68,838,692
Ensembl chr19:51,891,629...51,941,239

G

obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of OBSCN mRNA

NCBI chr10:44,273,686...44,419,275
Ensembl chr10:43,789,293...43,919,723

G

OCA2 melanosomal transmembrane protein

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of OCA2 gene

NCBI chr 1:116,252,026...116,581,838
Ensembl chr 1:107,116,278...107,446,074

G

opioid related nociceptin receptor 1

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of OPRL1 gene

NCBI chr 3:189,209,495...189,225,406
Ensembl chr 3:168,834,003...168,839,920

G

opioid receptor, mu 1

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of OPRM1 gene

NCBI chr 1:45,565,371...45,818,722
Ensembl chr 1:43,160,057...43,413,409

G

olfactory receptor family 10 subfamily D member 3

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of OR10D3 mRNA

NCBI chr 8:48,734,800...48,735,738
Ensembl chr 8:39,837,661...39,838,599

G

olfactory receptor family 5 subfamily E member 1

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of OR5E1 mRNA

NCBI chr 1:162,724,328...162,725,263
Ensembl chr 1:162,718,237...162,727,919

G

oxysterol binding protein 2

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of OSBP2 mRNA

NCBI chr14:82,808,693...82,970,386
Ensembl chr14:78,585,089...78,746,786

G

oxysterol binding protein-like 6

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of OSBPL6 mRNA

NCBI chr 3:81,751,020...81,948,186
Ensembl chr 3:61,343,809...61,537,102

G

otoferlin

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of OTOF exon; Ethylnitrosourea results in increased mutagenesis of OTOF gene

PMID:17329413 PMID:17967520

NCBI chr 6:31,647,869...31,744,476
Ensembl chr 6:25,928,055...26,024,631

G

otopetrin 1

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of OTOP1 gene

NCBI chr14:76,717,330...76,744,785
Ensembl chr14:72,503,592...72,532,497

G

p21 (RAC1) activated kinase 4

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of PAK4 exon

NCBI chr 1:92,977,437...93,016,721
Ensembl chr 1:83,849,904...83,859,413

G

poly (ADP-ribose) polymerase family, member 9

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of PARP9 gene

NCBI chr11:78,286,282...78,320,409
Ensembl chr11:64,780,981...64,815,455

G

paired box 3

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of PAX3 gene

NCBI chr 9:87,015,960...87,112,531
Ensembl chr 9:79,568,634...79,664,042

G

paired box 6

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of PAX6 exon; Ethylnitrosourea results in increased mutagenesis of PAX6 gene; Ethylnitrosourea results in increased mutagenesis of PAX6 intron

PMID:16303964 PMID:16724327

NCBI chr 3:112,590,034...112,611,771
Ensembl chr 3:92,135,637...92,157,014

G

protocadherin related 15

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of PCDH15 gene

NCBI chr20:13,996,383...15,495,206
Ensembl chr20:13,963,565...15,494,719

G

protocadherin alpha 4

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of PCDHA4 intron

NCBI chr18:28,688,274...29,120,227
Ensembl chr18:28,581,225...28,846,211

G

protocadherin beta 19

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of PCDHB19 mRNA

NCBI chr18:29,478,848...29,481,656

G

proliferating cell nuclear antigen

increases expression

Ethylnitrosourea results in increased expression of PCNA mRNA
Ethylnitrosourea results in increased expression of PCNA protein

PMID:15954086 PMID:28549617

NCBI chr 3:139,951,948...139,955,820
Ensembl chr 3:119,498,810...119,502,995

G

proprotein convertase subtilisin/kexin type 5

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of PCSK5 gene

NCBI chr 1:224,263,823...224,694,350
Ensembl chr 1:214,837,927...215,267,600

G

phosphodiesterase 4C

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of PDE4C mRNA

NCBI chr16:18,724,703...18,745,528
Ensembl chr16:18,691,700...18,710,640

G

phosphodiesterase 6B

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of PDE6B gene

NCBI chr14:1,468,302...1,511,435
Ensembl chr14:1,323,310...1,366,450

G

pyruvate dehydrogenase phosphatase catalytic subunit 1

increases expression

Ethylnitrosourea results in increased expression of PDP1 mRNA

NCBI chr 5:30,245,699...30,252,494
Ensembl chr 5:25,446,272...25,455,217

G

3-phosphoinositide dependent protein kinase-1

increases expression

Ethylnitrosourea results in increased expression of PDPK1 protein

NCBI chr10:13,610,000...13,687,226
Ensembl chr10:13,105,498...13,174,623

G

PHD finger protein 2

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of PHF2 intron

NCBI chr17:15,989,594...16,057,583
Ensembl chr17:15,781,864...15,851,208

G

phosphatidylinositol glycan anchor biosynthesis, class A

multiple interactions
increases mutagenesis

[Ethylnitrosourea results in increased mutagenesis of and results in decreased activity of PIGA protein] which affects the localization of CD59 protein; [Ethylnitrosourea results in increased mutagenesis of PIGA gene] which results in decreased expression of CD59 protein; Ethylnitrosourea results in increased mutagenesis of and results in decreased activity of PIGA protein
Ethylnitrosourea results in increased mutagenesis of PIGA; Ethylnitrosourea results in increased mutagenesis of PIGA gene

PMID:19965957 PMID:20202993 PMID:20857433 PMID:21729764 PMID:22167886 More...

NCBI chr X:33,672,832...33,687,747
Ensembl chr X:30,042,343...30,055,804

G

PTEN induced kinase 1

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of PINK1 gene

NCBI chr 5:155,813,838...155,825,950
Ensembl chr 5:150,530,523...150,542,635

G

phosphatidylinositol transfer protein, membrane-associated 1

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of PITPNM1 gene; Ethylnitrosourea results in increased mutagenesis of PITPNM1 intron

NCBI chr 1:210,823,568...210,836,989
Ensembl chr 1:201,394,149...201,407,522

G

pejvakin

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of PJVK gene

NCBI chr 3:82,002,106...82,012,273
Ensembl chr 3:61,596,641...61,605,045

G

polycystin 1, transient receptor potential channel interacting

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of PKD1 gene; Ethylnitrosourea results in increased mutagenesis of PKD1 mRNA

PMID:16724327 PMID:27776689

NCBI chr10:14,077,733...14,125,682
Ensembl chr10:13,573,021...13,621,128

G

polycystin family receptor for egg jelly

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of PKDREJ mRNA

NCBI chr 7:116,909,094...116,915,468
Ensembl chr 7:116,909,094...116,915,468

G

phospholipase A2, activating protein

increases expression

Ethylnitrosourea results in increased expression of PLAA mRNA

NCBI chr 5:114,544,327...114,576,023
Ensembl chr 5:109,428,265...109,460,282

G

phospholipase C beta 3

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of PLCB3 mRNA

NCBI chr 1:213,572,499...213,589,585
Ensembl chr 1:204,144,956...204,160,228

G

phospholipase C, gamma 2

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of PLCG2 gene

NCBI chr19:62,456,196...62,592,684
Ensembl chr19:45,547,416...45,683,930

G

pleckstrin homology domain containing M3

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of PLEKHM3 mRNA

NCBI chr 9:73,659,998...73,819,079
Ensembl chr 9:66,166,321...66,325,294

G

perilipin 1

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of PLIN1 mRNA

NCBI chr 1:143,073,612...143,086,199
Ensembl chr 1:133,664,892...133,676,828

G

perilipin 3

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of PLIN3 mRNA

NCBI chr 9:1,198,336...1,210,212
Ensembl chr 9:1,102,366...1,123,147

G

polo-like kinase 2

increases expression

Ethylnitrosourea results in increased expression of PLK2 mRNA

NCBI chr 2:43,702,536...43,708,305
Ensembl chr 2:41,969,176...41,974,947

G

plexin B2

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of PLXNB2 intron; Ethylnitrosourea results in increased mutagenesis of PLXNB2 mRNA

NCBI chr 7:122,111,917...122,138,201
Ensembl chr 7:120,232,331...120,258,330

G

pro-melanin-concentrating hormone

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of PMCH gene

NCBI chr 7:24,399,404...24,400,720
Ensembl chr 7:22,511,934...22,513,250

G

peripheral myelin protein 22

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of PMP22 gene

NCBI chr10:48,294,932...48,324,941
Ensembl chr10:47,795,709...47,825,714

G

protein O-glucosyltransferase 1

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of POGLUT1 gene

NCBI chr11:75,704,119...75,731,964
Ensembl chr11:62,198,513...62,226,434

G

DNA polymerase delta 1, catalytic subunit

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of POLD1 3' UTR; Ethylnitrosourea results in increased mutagenesis of POLD1 gene

NCBI chr 1:104,161,984...104,178,074
Ensembl chr 1:95,025,499...95,036,465

G

DNA polymerase theta

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of POLQ gene

NCBI chr11:77,179,190...77,281,270
Ensembl chr11:63,673,816...63,775,878

G

RNA polymerase I subunit E

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of POLR1E mRNA

NCBI chr 5:64,075,123...64,090,900
Ensembl chr 5:59,279,460...59,295,369

G

protein-O-mannosyltransferase 1

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of POMT1 gene

NCBI chr 3:35,918,370...35,936,330
Ensembl chr 3:15,520,481...15,538,581

G

peroxisome proliferator activated receptor alpha

decreases expression
decreases activity

Ethylnitrosourea results in decreased expression of PPARA mRNA
Ethylnitrosourea results in decreased activity of PPARA protein

PMID:25689681 PMID:30203046

NCBI chr 7:118,712,261...118,780,723
Ensembl chr 7:116,832,756...116,895,346

G

PTPRF interacting protein alpha 3

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of PPFIA3 gene

NCBI chr 1:104,953,598...104,982,373
Ensembl chr 1:95,817,110...95,845,798

G

peptidylprolyl isomerase A

increases expression

Ethylnitrosourea results in increased expression of PPIA mRNA

NCBI chr14:85,491,223...85,496,884
Ensembl chr14:81,275,091...81,299,601

G

protein phosphatase 1, regulatory subunit 21

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of PPP1R21 intron

NCBI chr 6:11,655,059...11,724,219
Ensembl chr 6:5,901,518...5,970,684

G

protein phosphatase 1, regulatory subunit 3C

increases expression

Ethylnitrosourea results in increased expression of PPP1R3C mRNA

NCBI chr 1:243,873,524...243,878,527
Ensembl chr 1:234,460,652...234,465,961

G

DNA primase subunit 1

increases expression

Ethylnitrosourea results in increased expression of PRIM1 mRNA

NCBI chr 7:1,031,436...1,047,134
Ensembl chr 7:431,805...462,526

G

protein kinase cAMP-dependent type I regulatory subunit beta

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of PRKAR1B mRNA

NCBI chr12:20,606,066...20,738,766
Ensembl chr12:15,511,801...15,624,942

G

protein kinase cAMP-dependent type II regulatory subunit beta

increases expression

Ethylnitrosourea results in increased expression of PRKAR2B mRNA

NCBI chr 6:54,291,143...54,381,639
Ensembl chr 6:48,563,662...48,653,933

G

serine protease 1

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of TRY10 intron

NCBI chr 4:71,331,249...71,334,452
Ensembl chr 4:70,364,586...70,367,792

G

proteasome 26S subunit, ATPase 2

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of PSMC2 intron

NCBI chr 4:14,148,080...14,162,390
Ensembl chr 4:13,255,856...13,270,185

G

proteasome 26S subunit, non-ATPase 13

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of PSMD13 intron

NCBI chr 1:205,394,248...205,406,525
Ensembl chr 1:195,964,138...195,976,905

G

phosphatase and tensin homolog

increases mutagenesis
decreases expression

Ethylnitrosourea results in increased mutagenesis of PTEN gene
Ethylnitrosourea results in decreased expression of PTEN protein

PMID:15755804 PMID:16724327 PMID:32902906

NCBI chr 1:240,043,707...240,110,330
Ensembl chr 1:230,630,338...230,696,838

G

prostaglandin-endoperoxide synthase 2

increases expression
multiple interactions

Ethylnitrosourea results in increased expression of PTGS2
Phytic Acid inhibits the reaction [Ethylnitrosourea results in increased expression of PTGS2]

NCBI chr13:64,714,063...64,722,320
Ensembl chr13:62,163,932...62,172,188

G

protein tyrosine phosphatase, non-receptor type 18

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of PTPN18 mRNA

NCBI chr 9:36,672,325...36,689,963
Ensembl chr 9:36,672,362...36,690,995

G

protein tyrosine phosphatase, receptor type, C

increases mutagenesis
decreases expression

Ethylnitrosourea results in increased mutagenesis of PTPRC gene
Ethylnitrosourea results in decreased expression of PTPRC protein

PMID:16724327 PMID:27725143

NCBI chr13:52,147,717...52,259,810
Ensembl chr13:49,596,193...49,708,692

G

PTTG1 regulator of sister chromatid separation, securin

decreases expression

Ethylnitrosourea results in decreased expression of PTTG1 mRNA

NCBI chr10:28,394,940...28,406,410
Ensembl chr10:27,893,689...27,904,837

G

QKI, KH domain containing RNA binding

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of QKI gene

NCBI chr 1:52,935,357...53,047,338
Ensembl chr 1:50,387,698...50,498,831

G

RAB14, member RAS oncogene family

decreases expression

Ethylnitrosourea results in decreased expression of RAB14 mRNA

NCBI chr 3:38,899,430...38,920,572
Ensembl chr 3:18,501,963...18,523,172

G

RAB23, member RAS oncogene family

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of RAB23 gene

NCBI chr 9:43,440,047...43,463,327
Ensembl chr 9:35,944,085...35,966,927

G

RAB3A, member RAS oncogene family

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of RAB3A gene

NCBI chr16:18,718,164...18,722,273
Ensembl chr16:18,684,188...18,688,336

G

Rap guanine nucleotide exchange factor 6

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of RAPGEF6 intron

NCBI chr10:39,156,573...39,324,947
Ensembl chr10:38,655,867...38,823,211

G

RAS p21 protein activator 3

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of RASA3 intron

NCBI chr16:75,855,360...75,969,349
Ensembl chr16:75,855,265...75,970,804

G

RAS protein-specific guanine nucleotide-releasing factor 1

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of RASGRF1 gene

NCBI chr 8:99,324,986...99,454,099
Ensembl chr 8:90,445,154...90,574,269

G

RB transcriptional corepressor 1

increases expression

Ethylnitrosourea results in increased expression of RB1 mRNA

NCBI chr15:54,780,858...54,911,989
Ensembl chr15:48,371,296...48,502,302

G

RNA binding motif protein 22

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of RBM22 mRNA

NCBI chr18:56,283,807...56,294,615
Ensembl chr18:54,013,351...54,024,569

G

regulator of calcineurin 1

increases expression

Ethylnitrosourea results in increased expression of RCAN1 mRNA

NCBI chr11:45,108,123...45,188,065
Ensembl chr11:31,622,210...31,702,045

G

retinol dehydrogenase 10

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of RDH10 mRNA

NCBI chr 5:7,969,931...7,998,834
Ensembl chr 5:3,188,445...3,215,572

G

RecQ like helicase 4

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of RECQL4 mRNA

NCBI chr 7:110,304,092...110,311,426
Ensembl chr 7:108,423,455...108,430,619

G

reelin

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of RELN gene

NCBI chr 4:13,628,440...14,055,201
Ensembl chr 4:12,736,130...13,162,211

G

replication initiator 1

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of REPIN1 3' UTR

NCBI chr 4:78,879,910...78,885,143
Ensembl chr 4:77,548,849...77,554,257

G

regulatory factor X4

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of RFX4 mRNA

NCBI chr 7:20,740,760...20,903,355
Ensembl chr 7:18,853,322...19,014,967

G

regulator of G-protein signaling 2

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of RGS2 gene

NCBI chr13:58,350,063...58,352,666
Ensembl chr13:55,798,829...55,802,385

G

rhodopsin

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of RHO gene

NCBI chr 4:150,653,205...150,658,367
Ensembl chr 4:148,980,611...148,985,773

G

ring finger protein 38

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of RNF38 intron

NCBI chr 5:63,154,507...63,263,138
Ensembl chr 5:58,361,976...58,467,446

G

ribosomal protein L27A

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of RPL27A gene

NCBI chr 1:172,971,957...172,977,591

G

ribosomal protein L7

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of RPL7 mRNA

NCBI chr 5:8,000,446...8,003,454

G

regulation of nuclear pre-mRNA domain containing 1A

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of RPRD1A gene

NCBI chr18:15,791,418...15,839,338
Ensembl chr18:15,791,418...15,839,338

G

regulatory associated protein of MTOR, complex 1

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of RPTOR intron

NCBI chr10:105,376,943...105,675,416
Ensembl chr10:104,878,487...105,176,983

G

ribonucleotide reductase regulatory TP53 inducible subunit M2B

increases expression

Ethylnitrosourea results in increased expression of RRM2B mRNA

NCBI chr 7:70,962,008...70,993,726
Ensembl chr 7:69,078,291...69,108,633

G

retinoschisin 1

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of RS1 intron

NCBI chr X:37,771,135...37,800,894
Ensembl chr X:33,963,657...33,992,115

G

regulator of telomere elongation helicase 1

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of RTEL1 mRNA

NCBI chr 3:188,778,329...188,842,877
Ensembl chr 3:168,419,579...168,465,348

G

Rtf1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of RTF1 mRNA

NCBI chr 3:127,113,171...127,172,761
Ensembl chr 3:106,659,308...106,718,970

G

stearoyl-CoA desaturase

decreases expression

Ethylnitrosourea results in decreased expression of SCD1 mRNA

NCBI chr 1:253,218,968...253,232,101
Ensembl chr 1:243,269,747...243,282,562

G

sodium voltage-gated channel alpha subunit 8

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of SCN8A exon; Ethylnitrosourea results in increased mutagenesis of SCN8A gene

PMID:15170223 PMID:19261867

NCBI chr 7:133,860,901...134,034,809
Ensembl chr 7:131,982,480...132,151,292

G

sodium channel epithelial 1 subunit gamma

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of SCNN1G intron

NCBI chr 1:185,736,225...185,770,099
Ensembl chr 1:176,304,942...176,338,816

G

signal peptide, CUB domain and EGF like domain containing 2

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of SCUBE2 intron

NCBI chr 1:173,264,862...173,341,323
Ensembl chr 1:163,832,015...163,899,393

G

semaphorin 3C

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of SEMA3C gene

NCBI chr 4:18,538,452...18,702,453
Ensembl chr 4:17,583,212...17,746,534

G

splicing factor 3b, subunit 2

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of SF3B2 intron

NCBI chr 1:211,999,777...212,040,686
Ensembl chr 1:202,570,423...202,590,759

G

SFI1 centrin binding protein

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of SFI1 gene; Ethylnitrosourea results in increased mutagenesis of SFI1 intron

NCBI chr14:82,215,423...82,272,811
Ensembl chr14:77,990,965...78,048,255

G

serum/glucocorticoid regulated kinase 1

increases expression

Ethylnitrosourea results in increased expression of SGK1 mRNA

NCBI chr 1:24,799,391...24,916,886
Ensembl chr 1:22,980,261...23,098,283

G

SH2 domain containing 4A

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of SH2D4A intron

NCBI chr16:26,106,721...26,176,069
Ensembl chr16:21,340,015...21,409,260

G

sonic hedgehog signaling molecule

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of SHH enhancer

NCBI chr 4:7,687,872...7,697,025
Ensembl chr 4:6,954,017...6,963,170

G

SIM bHLH transcription factor 1

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of SIM1 gene

NCBI chr20:55,409,814...55,489,450
Ensembl chr20:53,828,364...53,907,212

G

solute carrier family 4 member 1 (Diego blood group)

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of SLC4A1 gene

NCBI chr10:87,807,010...87,823,274
Ensembl chr10:87,306,872...87,323,117

G

solute carrier family 6 member 3

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of SLC6A3 gene

NCBI chr 1:31,537,990...31,578,962
Ensembl chr 1:29,709,443...29,750,413

G

solute carrier family 6 member 4

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of SLC6A4 gene

NCBI chr10:62,322,688...62,357,060
Ensembl chr10:61,826,123...61,858,384

G

solute carrier family 6 member 8

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of SLC6A8 gene

NCBI chr X:156,536,017...156,545,321
Ensembl chr X:151,384,675...151,393,979

G

solute carrier family 8 member B1

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of SLC8B1 mRNA

NCBI chr12:41,690,333...41,713,657
Ensembl chr12:36,029,760...36,053,031

G

solute carrier organic anion transporter family, member 2a1

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of SLCO2A1 mRNA

NCBI chr 8:112,467,739...112,551,923
Ensembl chr 8:103,588,916...103,672,546

G

schlafen family member 5

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of SLFN5 mRNA

NCBI chr10:68,378,440...68,392,515
Ensembl chr10:67,880,009...67,893,109

G

SMAD family member 2

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of SMAD2 gene

NCBI chr18:72,124,792...72,193,345
Ensembl chr18:69,850,377...69,912,323

G

SMAD family member 4

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of SMAD4 gene

NCBI chr18:69,518,988...69,549,684
Ensembl chr18:67,243,742...67,274,438

G

SWI/SNF related BAF chromatin remodeling complex subunit B1

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of SMARCB1 gene

NCBI chr20:12,740,105...12,763,054
Ensembl chr20:12,741,477...12,763,620

G

smoothened, frizzled class receptor

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of SMO gene

PMID:15755804 PMID:16724327

NCBI chr 4:59,311,084...59,341,280
Ensembl chr 4:58,343,529...58,373,829

G

stannin

increases expression

Ethylnitrosourea results in increased expression of SNN mRNA

NCBI chr10:5,079,885...5,088,565
Ensembl chr10:4,572,376...4,584,021
Ensembl chr 1:4,572,376...4,584,021

G

small nucleolar RNA, H/ACA box 75

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of SNORA75 gene

NCBI chr 9:87,000,248...87,000,384
Ensembl chr 9:87,000,248...87,000,384

G

superoxide dismutase 1

decreases expression

Ethylnitrosourea results in decreased expression of SOD1 mRNA

NCBI chr11:42,942,742...42,948,399
Ensembl chr11:29,456,558...29,462,249

G

sosondowah ankyrin repeat domain family member B

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of SOWAHB mRNA

NCBI chr14:15,313,561...15,317,396
Ensembl chr14:15,029,395...15,031,698

G

secreted protein acidic and cysteine rich

increases expression

Ethylnitrosourea results in increased expression of SPARC mRNA

NCBI chr10:40,017,065...40,038,816
Ensembl chr10:39,516,406...39,538,396

G

spermatogenesis associated 25

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of SPATA25 gene

NCBI chr 3:173,981,863...173,983,818
Ensembl chr 3:153,562,528...153,564,480

G

striated muscle enriched protein kinase

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of SPEG mRNA

NCBI chr 9:84,314,387...84,371,816
Ensembl chr 9:76,865,754...76,923,144

G

SPG11 vesicle trafficking associated, spatacsin

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of SPG11 mRNA

NCBI chr 3:129,453,118...129,526,469
Ensembl chr 3:109,008,135...109,072,911

G

Spi-B transcription factor

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of SPIB gene

NCBI chr 1:104,155,456...104,161,311
Ensembl chr 1:95,018,947...95,024,780

G

serine peptidase inhibitor, Kunitz type 1

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of SPINT1 intron

NCBI chr 3:126,685,017...126,697,957
Ensembl chr 3:106,231,444...106,244,119

G

spondin 2

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of SPON2 intron

NCBI chr14:81,713,070...81,742,510
Ensembl chr14:77,511,901...77,517,996

G

secreted phosphoprotein 1

increases expression

Ethylnitrosourea results in increased expression of SPP1 mRNA

NCBI chr14:5,613,569...5,620,695
Ensembl chr14:5,308,885...5,315,162

G

signal transducer and activator of transcription 1

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of STAT1 gene

PMID:16688530 PMID:16724327

NCBI chr 9:56,911,522...56,951,926
Ensembl chr 9:49,419,340...49,588,540

G

signal transducer and activator of transcription 3

decreases phosphorylation
increases mutagenesis

Ethylnitrosourea results in decreased phosphorylation of STAT3 protein
Ethylnitrosourea results in increased mutagenesis of STAT3 mRNA

PMID:27725143 PMID:27776689

NCBI chr10:86,311,528...86,363,513
Ensembl chr10:85,811,218...85,863,057

G

signal transducer and activator of transcription 5A

increases phosphorylation

Ethylnitrosourea results in increased phosphorylation of STAT5 protein

NCBI chr10:86,285,859...86,310,187
Ensembl chr10:85,785,537...85,809,866

G

signal transducer and activator of transcription 5B

increases activity

Ethylnitrosourea results in increased activity of STAT5B protein

NCBI chr10:86,205,148...86,276,178
Ensembl chr10:85,705,670...85,775,668

G

striatin interacting protein 1

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of STRIP1 intron

NCBI chr 2:197,936,569...197,956,515
Ensembl chr 2:195,248,386...195,268,481

G

syntaxin 2

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of STX2 gene

NCBI chr12:33,315,447...33,350,788
Ensembl chr12:27,689,819...27,714,751

G

syntaxin binding protein 4

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of STXBP4 gene

NCBI chr10:75,798,938...75,955,817
Ensembl chr10:75,305,463...75,458,663

G

spectrin repeat containing nuclear envelope protein 2

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of SYNE2 intron

NCBI chr 6:100,272,729...100,586,364
Ensembl chr 6:94,537,088...94,848,064

G

synaptophysin

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of SYP gene

NCBI chr X:17,521,348...17,536,449
Ensembl chr X:14,849,444...14,864,745

G

tubulin folding cofactor D

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of TBCD intron

NCBI chr10:107,215,626...107,372,398
Ensembl chr10:106,717,367...106,874,122

G

T-box transcription factor 6

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of TBX6 gene

PMID:15755804 PMID:16724327

NCBI chr 1:190,818,397...190,823,824
Ensembl chr 1:181,388,684...181,392,593

G

TEK receptor tyrosine kinase

increases expression

Ethylnitrosourea results in increased expression of TEK protein

NCBI chr 5:114,722,815...114,849,535
Ensembl chr 5:109,607,077...109,733,804

G

testis expressed 46

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of TEX46 mRNA

NCBI chr 5:148,849,307...148,853,742
Ensembl chr 5:148,849,307...148,853,742

G

transcription factor CP2-like 1

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of TFCP2L1 intron

NCBI chr13:32,286,643...32,346,671
Ensembl chr13:29,733,840...29,793,870

G

transferrin receptor

increases expression

Ethylnitrosourea results in increased expression of TFRC protein

NCBI chr11:81,668,478...81,690,318
Ensembl chr11:68,163,413...68,185,257

G

tyrosine hydroxylase

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of TH gene

NCBI chr 1:207,500,959...207,508,276
Ensembl chr 1:198,071,503...198,109,767

G

TIR domain containing adaptor molecule 1

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of TICAM1 gene

PMID:16724327 PMID:27776689

NCBI chr 9:1,189,717...1,197,730
Ensembl chr 9:1,102,366...1,123,147

G

toll-like receptor 8

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of TLR8 mRNA

NCBI chr X:30,708,714...30,733,104
Ensembl chr X:27,091,778...27,116,549

G

toll-like receptor 9

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of TLR9 gene

NCBI chr 8:115,743,407...115,747,523
Ensembl chr 8:106,864,680...106,868,796

G

transmembrane p24 trafficking protein 4

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of TMED4 gene; Ethylnitrosourea results in increased mutagenesis of TMED4 intron

NCBI chr14:85,338,980...85,343,577
Ensembl chr14:81,125,053...81,129,631

G

transmembrane protein 8B

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of TMEM8B intron

NCBI chr 5:62,715,238...62,744,187
Ensembl chr 5:57,919,804...57,946,772

G

transmembrane protein 91

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of TMEM91 3' UTR; Ethylnitrosourea results in increased mutagenesis of TMEM91 mRNA

NCBI chr 1:90,307,264...90,314,796
Ensembl chr 1:81,179,156...81,185,164

G

transmembrane serine protease 7

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of TMPRSS7 mRNA

NCBI chr11:68,583,710...68,629,200
Ensembl chr11:55,128,998...55,164,882

G

tumor necrosis factor

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of TNF exon

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629

G

tumor protein p53

increases mutagenesis
affects response to substance
increases response to substance
increases expression
multiple interactions
decreases expression

Ethylnitrosourea results in increased mutagenesis of TP53 gene
Ethylnitrosourea results in increased mutagenesis of TRP53 exon; Ethylnitrosourea results in increased mutagenesis of TRP53 gene
TRP53 affects the susceptibility to Ethylnitrosourea
TRP53 gene mutant form results in increased susceptibility to Ethylnitrosourea
Ethylnitrosourea results in increased expression of TRP53 protein
[Ethylnitrosourea results in increased mutagenesis of TP53 gene] which results in decreased activity of TP53 protein
Ethylnitrosourea results in decreased expression of TRP53 protein

PMID:9667752 PMID:11053539 PMID:14715658 PMID:15790496 PMID:16357521 More...

NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,300,048...54,311,524

G

tripartite motif-containing 11

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of TRIM11 gene

NCBI chr10:44,255,019...44,270,711
Ensembl chr10:43,758,354...43,771,138

G

tripartite motif containing 60

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of TRIM60 intron

NCBI chr16:24,722,770...24,724,188

G

transient receptor potential cation channel, subfamily M, member 4

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of TRPM4 gene

NCBI chr 1:104,918,462...104,949,453
Ensembl chr 1:95,782,000...95,812,532

G

TSR3 ribosome maturation factor

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of TSR3 gene

NCBI chr10:14,761,656...14,764,061
Ensembl chr10:14,257,171...14,259,561

G

tetratricopeptide repeat domain 13

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of TTC13 mRNA

NCBI chr19:69,534,989...69,589,590
Ensembl chr19:52,637,431...52,692,198

G

tetratricopeptide repeat domain 21B

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of TTC21B gene

NCBI chr 3:71,269,425...71,343,936
Ensembl chr 3:50,861,367...50,935,903

G

tetratricopeptide repeat domain 8

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of TTC8 mRNA

NCBI chr 6:123,927,657...124,025,354
Ensembl chr 6:118,198,201...118,252,418

G

tubulin tyrosine ligase like 10

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of TTLL10 intron

NCBI chr 5:171,912,371...171,937,733
Ensembl chr 5:166,630,152...166,653,707

G

tubulin, beta 4B class IVb

increases expression

Ethylnitrosourea results in increased expression of TUBB4B mRNA

NCBI chr 3:28,435,999...28,438,455
Ensembl chr 3:8,037,799...8,040,296

G

twist family bHLH transcription factor 1

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of TWIST1 gene

NCBI chr 6:56,402,309...56,404,303
Ensembl chr 6:50,674,678...50,677,653

G

thioredoxin reductase 3

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of TXNRD3 intron

NCBI chr 4:123,629,768...123,669,713
Ensembl chr 4:122,072,548...122,112,491

G

tyrosinase

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of TYR gene

PMID:9475716 PMID:16180137 PMID:17174358

NCBI chr 1:150,527,687...150,622,857
Ensembl chr 1:141,115,036...141,210,207

G

tyrosinase-related protein 1

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of TYRP1 gene

PMID:9475716 PMID:10517996 PMID:17174358

NCBI chr 5:100,327,111...100,345,657
Ensembl chr 5:95,280,982...95,299,516

G

U2 small nuclear RNA auxiliary factor 1-like 4

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of U2AF1L4 mRNA

NCBI chr 1:94,943,684...94,945,906
Ensembl chr 1:85,815,101...85,818,462

G

ubiquitin associated and SH3 domain containing, A

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of UBASH3A intron

NCBI chr20:9,292,819...9,336,036
Ensembl chr20:9,292,139...9,329,224

G

UDP-glucose ceramide glucosyltransferase

increases expression

Ethylnitrosourea results in increased expression of UGCG mRNA

NCBI chr 5:78,828,006...78,860,725
Ensembl chr 5:74,032,978...74,065,393

G

UDP-glucose 6-dehydrogenase

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of UGDH gene

NCBI chr14:43,202,480...43,226,002
Ensembl chr14:42,848,854...42,872,354

G

UDP glycosyltransferase family 3 member A1

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of UGT3A1 mRNA

NCBI chr 2:60,062,257...60,077,354
Ensembl chr 2:58,334,603...58,350,186

G

unc-51 like autophagy activating kinase 1

decreases phosphorylation
multiple interactions

Ethylnitrosourea results in decreased phosphorylation of ULK1 protein
Quercetin inhibits the reaction [Ethylnitrosourea results in decreased phosphorylation of ULK1 protein]

NCBI chr12:51,511,492...51,537,746
Ensembl chr12:45,851,710...45,877,966

G

unc-13 homolog D

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of UNC13D mRNA

NCBI chr10:101,795,652...101,810,409
Ensembl chr10:101,296,776...101,311,687

G

unk like zinc finger

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of UNKL gene

NCBI chr10:14,710,627...14,756,725
Ensembl chr10:14,206,189...14,252,225

G

UPF1, RNA helicase and ATPase

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of UPF1 intron

NCBI chr16:19,110,531...19,131,327
Ensembl chr16:19,076,322...19,096,568

G

ubiquitin specific peptidase 16

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of USP16 gene

NCBI chr11:40,166,651...40,196,792
Ensembl chr11:26,681,414...26,710,539

G

ubiquitin specific peptidase 29

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of USP29 exon

NCBI chr 1:75,907,331...75,959,896
Ensembl chr 1:66,874,017...67,097,686

G

UTP20 small subunit processome component

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of UTP20 intron

NCBI chr 7:25,022,029...25,103,024
Ensembl chr 7:23,134,637...23,215,632

G

vesicle amine transport 1

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of VAT1 mRNA

NCBI chr10:86,889,793...86,897,411
Ensembl chr10:86,389,545...86,397,224

G

vitamin K epoxide reductase complex, subunit 1-like 1

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of VKORC1L1 mRNA

NCBI chr12:32,354,078...32,404,327
Ensembl chr12:26,623,976...26,768,225

G

WD repeat and FYVE domain containing 3

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of WDFY3 intron

NCBI chr14:7,873,946...8,115,002
Ensembl chr14:7,606,628...7,810,482

G

WD repeat domain 6

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of WDR6 gene

NCBI chr 8:118,146,608...118,153,024
Ensembl chr 8:109,268,079...109,274,499

G

X-ray repair cross complementing 1

decreases expression

Ethylnitrosourea results in decreased expression of XRCC1 mRNA

NCBI chr 1:89,268,721...89,296,619
Ensembl chr 1:80,141,207...80,168,701

G

X-ray repair cross complementing 3

affects response to substance

XRCC3 gene polymorphism affects the susceptibility to Ethylnitrosourea

NCBI chr 6:136,684,558...136,694,822
Ensembl chr 6:130,863,959...130,872,444

G

xyloside xylosyltransferase 1

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of XXYLT1 mRNA

NCBI chr11:83,163,432...83,295,879
Ensembl chr11:69,658,460...69,790,730

G

ybeY metalloendoribonuclease

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of YBEY intron

NCBI chr20:12,164,678...12,175,150
Ensembl chr20:12,165,237...12,174,713

G

zeta chain of T cell receptor associated protein kinase 70

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of ZAP70 gene

NCBI chr 9:46,485,605...46,507,552
Ensembl chr 9:38,989,750...39,011,700

G

zinc finger DHHC-type palmitoyltransferase 14

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of ZDHHC14 intron

NCBI chr 1:48,473,860...48,746,201
Ensembl chr 1:46,069,127...46,330,488

G

zinc finger protein 110

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of ZFP110 mRNA

NCBI chr 1:82,509,563...82,533,294
Ensembl chr 1:73,445,336...73,461,086

G

zinc finger protein 319

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of ZFP319 mRNA

NCBI chr19:9,708,881...9,712,860
Ensembl chr19:9,702,144...9,713,198

G

zinc finger protein 568

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of ZFP568 gene

NCBI chr 1:94,334,011...94,385,166
Ensembl chr 1:85,207,579...85,257,505

G

zinc finger protein, multitype 2

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of ZFPM2 gene

NCBI chr 7:73,563,732...74,001,041
Ensembl chr 7:71,678,880...72,116,205

G

Zic family member 2

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of ZIC2 gene

NCBI chr15:105,982,711...105,988,167
Ensembl chr15:99,576,697...99,581,522

G

zinc finger, MIZ-type containing 1

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of ZMIZ1 intron

NCBI chr16:1,033,983...1,239,425
Ensembl chr16:1,027,325...1,232,597

G

zinc finger protein 750

increases mutagenesis

Ethylnitrosourea results in increased mutagenesis of ZFP750 mRNA

NCBI chr10:107,270,926...107,279,904
Ensembl chr10:106,772,669...106,781,200

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	19909
role	19880
biological role	19878
aetiopathogenetic role	19245
genotoxin	17693
N-ethyl-N-nitrosourea	513
Path 2
Term	Annotations
CHEBI ontology	19909
subatomic particle	19907
composite particle	19907
hadron	19907
baryon	19907
nucleon	19907
atomic nucleus	19907
atom	19907
main group element atom	19846
p-block element atom	19846
carbon group element atom	19784
carbon atom	19781
organic molecular entity	19781
heteroorganic entity	19540
organochalcogen compound	19301
organooxygen compound	19216
carbon oxoacid	18696
carboxylic acid	18693
carboacyl group	17718
univalent carboacyl group	17718
carbamoyl group	17564
carboxamide	17564
monocarboxylic acid amide	15744
urea	6236
ureas	6234
N-nitrosoureas	2131
N-ethyl-N-nitrosourea	513

paths to the root