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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:acetochlor
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Accession:CHEBI:2394 term browser browse the term
Definition:A monocarboxylic acid amide that is N-phenylacetamide carrying an ethyl and a methyl group at positions 2 and 6 respectively on the benzene ring while one of the methyl hydrogens as well as the hydrogen attached to the nitrogen atom have been replaced by a chloro and an ethoxymethyl group respectively.
Synonyms:exact_synonym: 2-chloro-N-(ethoxymethyl)-N-(2-ethyl-6-methylphenyl)acetamide
 related_synonym: 2-Chloro-2'-methyl-6-ethyl-N-ethoxymethylacetanilide;   2-Chloro-N-(ethoxymethyl)-6'-ethyl-o-acetotoluidide;   2-Chloro-N-(ethoxymethyl)-6'-ethylacet-o-toluidide;   Acetochlore;   Formula=C14H20ClNO2;   InChI=1S/C14H20ClNO2/c1-4-12-8-6-7-11(3)14(12)16(10-18-5-2)13(17)9-15/h6-8H,4-5,9-10H2,1-3H3;   InChIKey=VTNQPKFIQCLBDU-UHFFFAOYSA-N;   SMILES=CCOCN(C(=O)CCl)c1c(C)cccc1CC
 xref: Beilstein:2859702;   CAS:34256-82-1;   KEGG:C10925
 xref_mesh: MESH:C043377
 xref: PMID:16646021;   PMID:17534384;   PPDB:12;   Pesticides:acetochlor;   Reaxys:2859702;   Wikipedia:Acetochlor



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acetochlor term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A increases activity
multiple interactions
ISO acetochlor results in increased activity of ABCB1 protein
ABCB1 protein affects the reaction [acetochlor results in increased susceptibility to Paclitaxel]
CTD PMID:18433974 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 increases export ISO ABCC1 protein results in increased export of acetochlor metabolite CTD PMID:18433974 NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114
JBrowse link
G Aplf aprataxin and PNKP like factor affects response to substance ISO APLF gene SNP affects the susceptibility to acetochlor CTD PMID:25622337 NCBI chr 4:120,070,471...120,122,656
Ensembl chr 4:120,070,471...120,122,633
JBrowse link
G Ar androgen receptor multiple interactions ISO acetochlor inhibits the reaction [[6-fluorotestosterone co-treated with Norgestrel] binds to and results in increased activity of AR protein] CTD PMID:33049310 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925
JBrowse link
G Bad BCL2-associated agonist of cell death increases expression ISO acetochlor results in increased expression of BAD protein CTD PMID:25291404 NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823
JBrowse link
G Bak1 BCL2-antagonist/killer 1 increases expression ISO acetochlor results in increased expression of BAK1 protein CTD PMID:25291404 NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO acetochlor results in increased expression of BAX protein CTD PMID:25291404 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2l1 Bcl2-like 1 affects expression ISO acetochlor affects the expression of BCL2L1 protein CTD PMID:25291404 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
JBrowse link
G Bid BH3 interacting domain death agonist increases expression ISO acetochlor results in increased expression of BID protein CTD PMID:25291404 NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720
JBrowse link
G Casp3 caspase 3 multiple interactions
increases expression
ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [acetochlor results in increased expression of CASP3 protein modified form] CTD PMID:25291404 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp9 caspase 9 multiple interactions
increases cleavage
ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [acetochlor results in increased cleavage of CASP9 protein] CTD PMID:25291404 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases metabolic processing ISO CYP2B6 protein results in increased metabolism of acetochlor CTD PMID:11133395 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases metabolic processing ISO CYP3A4 protein results in increased metabolism of acetochlor CTD PMID:11133395 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO acetochlor binds to and results in decreased activity of ESR1 protein CTD PMID:33049310 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Esr2 estrogen receptor 2 multiple interactions ISO acetochlor binds to and results in decreased activity of ESR2 protein CTD PMID:33049310 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919
JBrowse link
G Gfral GDNF family receptor alpha like affects response to substance ISO GFRAL gene SNP affects the susceptibility to acetochlor CTD PMID:25622337 NCBI chr 8:76,917,894...76,963,349
Ensembl chr 8:76,918,657...76,959,425
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation
ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [acetochlor results in increased phosphorylation of MAPK1 protein] CTD PMID:25291404 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation
multiple interactions
ISO acetochlor results in increased phosphorylation of MAPK3 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [acetochlor results in increased phosphorylation of MAPK3 protein]
CTD PMID:25291404 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member affects expression ISO acetochlor affects the expression of MCL1 protein CTD PMID:25291404 NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO acetochlor binds to and results in increased activity of NR1I2 protein CTD PMID:33049310 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases cleavage
ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [acetochlor results in increased cleavage of PARP1 protein] CTD PMID:25291404 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO acetochlor binds to and results in increased activity of PPARG protein CTD PMID:33049310 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
JBrowse link
G Rimklb ribosomal modification protein rimK-like family member B affects response to substance ISO RIMKLB gene SNP affects the susceptibility to acetochlor CTD PMID:25622337 NCBI chr 4:155,664,392...155,706,888 JBrowse link
G Thrb thyroid hormone receptor beta affects binding
multiple interactions
ISO acetochlor binds to THRB protein
acetochlor binds to and results in decreased activity of THRB protein
CTD PMID:28973306 PMID:33049310 NCBI chr15:7,685,180...8,031,920
Ensembl chr15:7,685,180...7,882,916
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19795
    role 19746
      biological role 19746
        xenobiotic 18434
          acetochlor 24
Path 2
Term Annotations click to browse term
  CHEBI ontology 19795
    subatomic particle 19794
      composite particle 19794
        hadron 19794
          baryon 19794
            nucleon 19794
              atomic nucleus 19794
                atom 19794
                  main group element atom 19693
                    main group molecular entity 19693
                      s-block molecular entity 19474
                        hydrogen molecular entity 19466
                          hydrides 18830
                            inorganic hydride 17688
                              pnictogen hydride 17668
                                nitrogen hydride 17540
                                  azane 17273
                                    ammonia 17272
                                      organic amino compound 17272
                                        amine 7897
                                          primary amine 5830
                                            primary arylamine 3129
                                              aniline 2976
                                                anilide 498
                                                  N-phenylacetamide 223
                                                    acetochlor 24
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