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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:dimethoxyflavone
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Accession:CHEBI:23798 term browser browse the term
Definition:Any methoxyflavone with two methoxy substituents.
Synonyms:related_synonym: dimethoxyflavones


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3',4',5-trihydroxy-3,7-dimethoxyflavone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccnb1 cyclin B1 affects phosphorylation
increases expression
ISO 5,7,3'-trihydroxy-3,4'-dimethoxyflavone affects the phosphorylation of CCNB1 protein
5,7,3'-trihydroxy-3,4'-dimethoxyflavone results in increased expression of CCNB1 protein
CTD PMID:21229608 NCBI chr13:100,778,739...100,786,486
Ensembl chr13:100,778,650...100,786,570
JBrowse link
G Cdc25c cell division cycle 25C affects phosphorylation ISO 5,7,3'-trihydroxy-3,4'-dimethoxyflavone affects the phosphorylation of CDC25C protein CTD PMID:21229608 NCBI chr18:34,732,993...34,751,564
Ensembl chr18:34,732,993...34,751,533
JBrowse link
G Cdk1 cyclin-dependent kinase 1 affects phosphorylation ISO 5,7,3'-trihydroxy-3,4'-dimethoxyflavone affects the phosphorylation of CDK1 protein CTD PMID:21229608 NCBI chr10:69,335,146...69,352,912
Ensembl chr10:69,335,146...69,352,938
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A (P21) increases expression ISO 5,7,3'-trihydroxy-3,4'-dimethoxyflavone results in increased expression of CDKN1A protein CTD PMID:21229608 NCBI chr17:29,090,979...29,100,722
Ensembl chr17:29,090,976...29,100,727
JBrowse link
G Foxm1 forkhead box M1 affects phosphorylation ISO 5,7,3'-trihydroxy-3,4'-dimethoxyflavone affects the phosphorylation of FOXM1 protein CTD PMID:21229608 NCBI chr 6:128,362,994...128,375,886
Ensembl chr 6:128,362,967...128,376,146
JBrowse link
G Smpd1 sphingomyelin phosphodiesterase 1, acid lysosomal increases activity ISO 5,7,3'-trihydroxy-3,4'-dimethoxyflavone results in increased activity of SMPD1 protein CTD PMID:21229608 NCBI chr 7:105,554,360...105,558,389
Ensembl chr 7:105,554,360...105,558,389
JBrowse link
3',5'-di-O-methyltricetin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO tricin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 protein] CTD PMID:16552572 NCBI chr 1:150,100,031...150,108,234
Ensembl chr 1:150,100,031...150,108,227
JBrowse link
3',5'-dimethoxyflavone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl-hydrocarbon receptor multiple interactions EXP 3',5'-dimethoxyflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein] CTD PMID:12644593 NCBI chr12:35,497,979...35,534,989
Ensembl chr12:35,497,974...35,535,038
JBrowse link
chrysin 5,7-dimethyl ether term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2-associated X protein multiple interactions ISO [5,7-dimethoxyflavone co-treated with Diethylnitrosamine] results in increased expression of BAX protein CTD PMID:21554863 NCBI chr 7:45,461,695...45,466,903
Ensembl chr 7:45,461,697...45,466,898
JBrowse link
G Bcl2l1 BCL2-like 1 multiple interactions ISO 5,7-dimethoxyflavone inhibits the reaction [Diethylnitrosamine results in increased expression of BCL2L1 protein] CTD PMID:21554863 NCBI chr 2:152,758,732...152,833,803
Ensembl chr 2:152,780,668...152,831,728
JBrowse link
G Casp3 caspase 3 multiple interactions ISO 5,7-dimethoxyflavone promotes the reaction [Diethylnitrosamine results in increased expression of CASP3 protein] CTD PMID:21554863 NCBI chr 8:46,617,291...46,639,698
Ensembl chr 8:46,617,291...46,639,689
JBrowse link
G Ccl2 chemokine (C-C motif) ligand 2 multiple interactions ISO 5,7-dimethoxyflavone inhibits the reaction [IL1B protein results in increased secretion of CCL2 protein] CTD PMID:24134915 NCBI chr11:82,035,577...82,037,452
Ensembl chr11:82,035,571...82,037,453
JBrowse link
G Ccnd1 cyclin D1 multiple interactions ISO 5,7-dimethoxyflavone inhibits the reaction [Diethylnitrosamine results in increased expression of CCND1 mRNA]; 5,7-dimethoxyflavone inhibits the reaction [Diethylnitrosamine results in increased expression of CCND1 protein] CTD PMID:21554863 NCBI chr 7:144,929,931...144,939,831
Ensembl chr 7:144,929,931...144,939,925
JBrowse link
G Csnk2b casein kinase 2, beta polypeptide multiple interactions ISO 5,7-dimethoxyflavone inhibits the reaction [Diethylnitrosamine results in increased expression of CSNK2B mRNA]; 5,7-dimethoxyflavone inhibits the reaction [Diethylnitrosamine results in increased expression of CSNK2B protein] CTD PMID:21554863 NCBI chr17:35,116,195...35,122,053
Ensembl chr17:35,116,196...35,122,053
JBrowse link
G Ctnnb1 catenin (cadherin associated protein), beta 1 multiple interactions ISO 5,7-dimethoxyflavone inhibits the reaction [Diethylnitrosamine affects the localization of CTNNB1 protein modified form]; 5,7-dimethoxyflavone inhibits the reaction [Diethylnitrosamine results in increased expression of CTNNB1 mRNA] CTD PMID:21554863 NCBI chr 9:120,933,400...120,960,507
Ensembl chr 9:120,929,216...120,960,507
JBrowse link
G Cxcl15 chemokine (C-X-C motif) ligand 15 multiple interactions ISO 5,7-dimethoxyflavone inhibits the reaction [IL1B protein results in increased secretion of CXCL8 protein] CTD PMID:24134915 NCBI chr 5:90,794,534...90,803,067
Ensembl chr 5:90,794,534...90,803,067
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
decreases activity
ISO 5,7-dimethoxyflavone inhibits the reaction [Benzo(a)pyrene results in increased expression of and results in increased activity of CYP1A1 protein]; 5,7-dimethoxyflavone inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; 5,7-dimethoxyflavone inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]
5,7-dimethoxyflavone results in decreased activity of CYP1A1 protein
CTD PMID:15661813 PMID:15905203 PMID:16484233 NCBI chr 9:57,687,928...57,703,824
Ensembl chr 9:57,687,928...57,703,824
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 multiple interactions
decreases activity
ISO 5,7-dimethoxyflavone inhibits the reaction [Benzo(a)pyrene results in increased activity of CYP1B1 protein]; 5,7-dimethoxyflavone inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1B1 mRNA]; 5,7-dimethoxyflavone inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1B1 protein]
5,7-dimethoxyflavone results in decreased activity of CYP1B1 protein
CTD PMID:15905203 PMID:16484233 PMID:16530937 NCBI chr17:79,706,940...79,715,061
Ensembl chr17:79,701,537...79,715,061
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions ISO 5,7-dimethoxyflavone promotes the reaction [Diethylnitrosamine results in increased phosphorylation of GSK3B protein] CTD PMID:21554863 NCBI chr16:38,089,001...38,246,084
Ensembl chr16:38,089,001...38,246,084
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO 5,7-dimethoxyflavone inhibits the reaction [IL1B protein results in increased secretion of CCL2 protein]; 5,7-dimethoxyflavone inhibits the reaction [IL1B protein results in increased secretion of CXCL8 protein]; 5,7-dimethoxyflavone inhibits the reaction [IL1B protein results in increased secretion of IL6 protein] CTD PMID:24134915 NCBI chr 2:129,364,569...129,371,164
Ensembl chr 2:129,364,570...129,371,139
JBrowse link
G Il6 interleukin 6 multiple interactions ISO 5,7-dimethoxyflavone inhibits the reaction [IL1B protein results in increased secretion of IL6 protein] CTD PMID:24134915 NCBI chr 5:30,013,114...30,019,975
Ensembl chr 5:30,013,114...30,019,981
JBrowse link
G Nos2 nitric oxide synthase 2, inducible multiple interactions ISO 5,7-dimethoxyflavone inhibits the reaction [Diethylnitrosamine results in increased expression of NOS2 protein] CTD PMID:21554863 NCBI chr11:78,920,787...78,960,226
Ensembl chr11:78,920,787...78,960,254
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO 5,7-dimethoxyflavone inhibits the reaction [Diethylnitrosamine results in increased expression of PTGS2 mRNA]; 5,7-dimethoxyflavone inhibits the reaction [Diethylnitrosamine results in increased expression of PTGS2 protein] CTD PMID:21554863 NCBI chr 1:150,100,031...150,108,234
Ensembl chr 1:150,100,031...150,108,227
JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) multiple interactions ISO 5,7-dimethoxyflavone inhibits the reaction [Diethylnitrosamine results in increased expression of RELA mRNA]; 5,7-dimethoxyflavone inhibits the reaction [Diethylnitrosamine results in increased expression of RELA protein modified form] CTD PMID:21554863 NCBI chr19:5,637,442...5,648,134
Ensembl chr19:5,637,483...5,648,130
JBrowse link
G Trp53 transformation related protein 53 multiple interactions ISO [5,7-dimethoxyflavone co-treated with Diethylnitrosamine] results in increased expression of TP53 mRNA; [5,7-dimethoxyflavone co-treated with Diethylnitrosamine] results in increased expression of TP53 protein CTD PMID:21554863 NCBI chr11:69,580,348...69,591,873
Ensembl chr11:69,580,359...69,591,873
JBrowse link
G Wnt3a wingless-type MMTV integration site family, member 3A multiple interactions ISO 5,7-dimethoxyflavone inhibits the reaction [Diethylnitrosamine results in increased expression of WNT3A protein] CTD PMID:21554863 NCBI chr11:59,248,036...59,290,751
Ensembl chr11:59,248,033...59,290,752
JBrowse link
cirsiliol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases activity
increases metabolic processing
increases expression
ISO cirsiliol results in decreased activity of CYP1A1 protein
CYP1A1 protein results in increased metabolism of cirsiliol
cirsiliol results in increased expression of CYP1A1 mRNA
CTD PMID:19601638 PMID:21482471 NCBI chr 9:57,687,928...57,703,824
Ensembl chr 9:57,687,928...57,703,824
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 increases expression
decreases activity
increases metabolic processing
ISO cirsiliol results in increased expression of CYP1B1 mRNA
cirsiliol results in decreased activity of CYP1B1 protein
CYP1B1 protein results in increased metabolism of cirsiliol
CTD PMID:19601638 PMID:21482471 NCBI chr17:79,706,940...79,715,061
Ensembl chr17:79,701,537...79,715,061
JBrowse link
jaceosidin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2-associated X protein multiple interactions ISO jaceosidin results in increased expression of and results in increased activity of BAX protein CTD PMID:27729209 NCBI chr 7:45,461,695...45,466,903
Ensembl chr 7:45,461,697...45,466,898
JBrowse link
G Casp3 caspase 3 increases activity ISO jaceosidin results in increased activity of CASP3 protein CTD PMID:27729209 NCBI chr 8:46,617,291...46,639,698
Ensembl chr 8:46,617,291...46,639,689
JBrowse link
G Cflar CASP8 and FADD-like apoptosis regulator decreases expression
multiple interactions
ISO jaceosidin results in decreased expression of CFLAR mRNA; jaceosidin results in decreased expression of CFLAR protein
CFLAR protein inhibits the reaction [jaceosidin results in increased cleavage of PARP1 protein]; RELA protein inhibits the reaction [jaceosidin results in decreased expression of CFLAR protein]; SP1 protein inhibits the reaction [jaceosidin results in decreased expression of CFLAR protein]
CTD PMID:27729209 NCBI chr 1:58,711,311...58,758,884
Ensembl chr 1:58,711,508...58,758,884
JBrowse link
G Mcl1 myeloid cell leukemia sequence 1 decreases expression
multiple interactions
ISO jaceosidin results in decreased expression of MCL1 mRNA; jaceosidin results in decreased expression of MCL1 protein
MCL1 protein inhibits the reaction [jaceosidin results in increased cleavage of PARP1 protein]; RELA protein inhibits the reaction [jaceosidin results in decreased expression of MCL1 protein]; SP1 protein inhibits the reaction [jaceosidin results in decreased expression of MCL1 protein]
CTD PMID:27729209 NCBI chr 3:95,656,944...95,663,179
Ensembl chr 3:95,658,788...95,663,176
JBrowse link
G Parp1 poly (ADP-ribose) polymerase family, member 1 increases cleavage
multiple interactions
ISO jaceosidin results in increased cleavage of PARP1 protein
benzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [jaceosidin results in increased cleavage of PARP1 protein]; CFLAR protein inhibits the reaction [jaceosidin results in increased cleavage of PARP1 protein]; MCL1 protein inhibits the reaction [jaceosidin results in increased cleavage of PARP1 protein]
CTD PMID:27729209 NCBI chr 1:180,568,891...180,600,999
Ensembl chr 1:180,568,924...180,601,254
JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) multiple interactions ISO RELA protein inhibits the reaction [jaceosidin results in decreased expression of CFLAR protein]; RELA protein inhibits the reaction [jaceosidin results in decreased expression of MCL1 protein] CTD PMID:27729209 NCBI chr19:5,637,442...5,648,134
Ensembl chr19:5,637,483...5,648,130
JBrowse link
G Sp1 trans-acting transcription factor 1 multiple interactions ISO SP1 protein inhibits the reaction [jaceosidin results in decreased expression of CFLAR protein]; SP1 protein inhibits the reaction [jaceosidin results in decreased expression of MCL1 protein] CTD PMID:27729209 NCBI chr15:102,406,316...102,436,404
Ensembl chr15:102,406,143...102,436,404
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 21552
    chemical entity 21550
      atom 21537
        nonmetal atom 21418
          oxygen atom 20492
            oxygen molecular entity 20492
              organooxygen compound 19910
                ether 16345
                  methoxyflavone 416
                    dimethoxyflavone 29
                      3',4',5,6-tetrahydroxy-3,7-dimethoxyflavone 0
                      3',4',5-trihydroxy-3,7-dimethoxyflavone 6
                      3',5'-di-O-methyltricetin + 1
                      3',5'-dimethoxyflavone + 1
                      3,3'-dimethylquercetin 0
                      3,4'-dimethylkaempferol 0
                      4',6-dihydroxy-5,7-dimethoxyflavone 0
                      4'-O-beta-glucosyl-7-O-(6-O-sinapoylglucosyl)tricin 0
                      5,3'-di-O-methylluteolin 0
                      5,7,3',5'-tetrahydroxy-3,4'-dimethyoxyflavone 0
                      5,7,3'-trihydroxy-3,5'-dimethoxy-2'-(3'-methylbut-2-enyl)flavone 0
                      7,3',4'-trihydroxy-3,8-dimethoxyflavone 0
                      7,4'-dimethylkaempferol 0
                      apigenin 7,4'-dimethyl ether 0
                      axillarin 0
                      chrysin 5,7-dimethyl ether 18
                      cirsiliol 2
                      cirsimaritin 0
                      eupatolitin 0
                      isoorientin 7,3'-dimethyl ether 0
                      jaceosidin 7
                      ombuin 0
                      pectolinarigenin + 0
                      pectolinarin 0
                      quercetin 3,4'-dimethyl ether 0
                      rhamnacene + 0
                      syringetin 0
                      syringetin 3-glucoside 0
                      tricin 4'-O-(erythro-beta-guaiacylglyceryl) ether 7''-O-beta-D-glucopyranoside 0
                      tricin 4'-O-(erythro-beta-guaiacylglyceryl) ether 7-O-beta-D-glucopyranoside 0
                      tricin 4'-O-(erythro-beta-guaiacylglyceryl) ether 9''-O-beta-D-glucopyranoside 0
                      tricin 4'-O-(threo-beta-guaiacylglyceryl) ether 7-O-beta-D-glucopyranoside 0
                      tricin 5-O-beta-D-glucoside 0
                      tricin 7-O-(6''-O-malonyl)-beta-D-glucopyranoside 0
                      tricin 7-O-[sinapoyl]-glucoside 0
                      tricin 7-O-beta-D-glucoside 0
                      tricin 7-O-glucoside + 0
                      tricin 7-O-neohesperidoside 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 21552
    subatomic particle 21537
      composite particle 21537
        hadron 21537
          baryon 21537
            nucleon 21537
              atomic nucleus 21537
                atom 21537
                  main group element atom 21442
                    p-block element atom 21442
                      carbon group element atom 21235
                        carbon atom 21133
                          organic molecular entity 21133
                            organic molecule 21027
                              organic cyclic compound 20588
                                organic heterocyclic compound 19444
                                  oxacycle 17573
                                    benzopyran 10460
                                      1-benzopyran 10183
                                        flavonoid 6499
                                          flavones 4232
                                            methoxyflavone 416
                                              dimethoxyflavone 29
                                                3',4',5,6-tetrahydroxy-3,7-dimethoxyflavone 0
                                                3',4',5-trihydroxy-3,7-dimethoxyflavone 6
                                                3',5'-di-O-methyltricetin + 1
                                                3',5'-dimethoxyflavone + 1
                                                3,3'-dimethylquercetin 0
                                                3,4'-dimethylkaempferol 0
                                                4',6-dihydroxy-5,7-dimethoxyflavone 0
                                                4'-O-beta-glucosyl-7-O-(6-O-sinapoylglucosyl)tricin 0
                                                5,3'-di-O-methylluteolin 0
                                                5,7,3',5'-tetrahydroxy-3,4'-dimethyoxyflavone 0
                                                5,7,3'-trihydroxy-3,5'-dimethoxy-2'-(3'-methylbut-2-enyl)flavone 0
                                                7,3',4'-trihydroxy-3,8-dimethoxyflavone 0
                                                7,4'-dimethylkaempferol 0
                                                apigenin 7,4'-dimethyl ether 0
                                                axillarin 0
                                                chrysin 5,7-dimethyl ether 18
                                                cirsiliol 2
                                                cirsimaritin 0
                                                eupatolitin 0
                                                isoorientin 7,3'-dimethyl ether 0
                                                jaceosidin 7
                                                ombuin 0
                                                pectolinarigenin + 0
                                                pectolinarin 0
                                                quercetin 3,4'-dimethyl ether 0
                                                rhamnacene + 0
                                                syringetin 0
                                                syringetin 3-glucoside 0
                                                tricin 4'-O-(erythro-beta-guaiacylglyceryl) ether 7''-O-beta-D-glucopyranoside 0
                                                tricin 4'-O-(erythro-beta-guaiacylglyceryl) ether 7-O-beta-D-glucopyranoside 0
                                                tricin 4'-O-(erythro-beta-guaiacylglyceryl) ether 9''-O-beta-D-glucopyranoside 0
                                                tricin 4'-O-(threo-beta-guaiacylglyceryl) ether 7-O-beta-D-glucopyranoside 0
                                                tricin 5-O-beta-D-glucoside 0
                                                tricin 7-O-(6''-O-malonyl)-beta-D-glucopyranoside 0
                                                tricin 7-O-[sinapoyl]-glucoside 0
                                                tricin 7-O-beta-D-glucoside 0
                                                tricin 7-O-glucoside + 0
                                                tricin 7-O-neohesperidoside 0
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