Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:dimethoxyflavone
go back to main search page
Accession:CHEBI:23798 term browser browse the term
Definition:Any methoxyflavone with two methoxy substituents.
Synonyms:related_synonym: dimethoxyflavones


show annotations for term's descendants           Sort by:
 
3',4',5-trihydroxy-3,7-dimethoxyflavone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccnb1 cyclin B1 affects phosphorylation
increases expression
ISO 5,7,3'-trihydroxy-3,4'-dimethoxyflavone affects the phosphorylation of CCNB1 protein
5,7,3'-trihydroxy-3,4'-dimethoxyflavone results in increased expression of CCNB1 protein
CTD PMID:21229608 NCBI chr 2:30,782,133...30,791,106
Ensembl chr 2:30,783,915...30,791,221
JBrowse link
G Cdc25c cell division cycle 25C affects phosphorylation ISO 5,7,3'-trihydroxy-3,4'-dimethoxyflavone affects the phosphorylation of CDC25C protein CTD PMID:21229608 NCBI chr18:27,528,768...27,550,316
Ensembl chr18:27,528,354...27,550,224
JBrowse link
G Cdk1 cyclin-dependent kinase 1 affects phosphorylation ISO 5,7,3'-trihydroxy-3,4'-dimethoxyflavone affects the phosphorylation of CDK1 protein CTD PMID:21229608 NCBI chr20:20,576,341...20,591,510
Ensembl chr20:20,576,377...20,591,549
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO 5,7,3'-trihydroxy-3,4'-dimethoxyflavone results in increased expression of CDKN1A protein CTD PMID:21229608 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Foxm1 forkhead box M1 affects phosphorylation ISO 5,7,3'-trihydroxy-3,4'-dimethoxyflavone affects the phosphorylation of FOXM1 protein CTD PMID:21229608 NCBI chr 4:161,685,236...161,697,633
Ensembl chr 4:161,685,258...161,696,305
JBrowse link
G Smpd1 sphingomyelin phosphodiesterase 1 increases activity ISO 5,7,3'-trihydroxy-3,4'-dimethoxyflavone results in increased activity of SMPD1 protein CTD PMID:21229608 NCBI chr 1:170,383,682...170,387,525
Ensembl chr 1:170,383,682...170,387,524
JBrowse link
3',5'-di-O-methyltricetin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO tricin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 protein] CTD PMID:16552572 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
3',5'-dimethoxyflavone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor multiple interactions ISO 3',5'-dimethoxyflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein] CTD PMID:12644593 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
chrysin 5,7-dimethyl ether term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP [5,7-dimethoxyflavone co-treated with Diethylnitrosamine] results in increased expression of BAX protein CTD PMID:21554863 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions EXP 5,7-dimethoxyflavone inhibits the reaction [Diethylnitrosamine results in increased expression of BCL2L1 protein] CTD PMID:21554863 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Casp3 caspase 3 multiple interactions EXP 5,7-dimethoxyflavone promotes the reaction [Diethylnitrosamine results in increased expression of CASP3 protein] CTD PMID:21554863 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO 5,7-dimethoxyflavone inhibits the reaction [IL1B protein results in increased secretion of CCL2 protein] CTD PMID:24134915 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccnd1 cyclin D1 multiple interactions EXP 5,7-dimethoxyflavone inhibits the reaction [Diethylnitrosamine results in increased expression of CCND1 mRNA]; 5,7-dimethoxyflavone inhibits the reaction [Diethylnitrosamine results in increased expression of CCND1 protein] CTD PMID:21554863 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Csnk2b casein kinase 2 beta multiple interactions EXP 5,7-dimethoxyflavone inhibits the reaction [Diethylnitrosamine results in increased expression of CSNK2B mRNA]; 5,7-dimethoxyflavone inhibits the reaction [Diethylnitrosamine results in increased expression of CSNK2B protein] CTD PMID:21554863 NCBI chr20:5,108,692...5,113,675
Ensembl chr20:5,106,890...5,113,112
JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions EXP 5,7-dimethoxyflavone inhibits the reaction [Diethylnitrosamine affects the localization of CTNNB1 protein modified form]; 5,7-dimethoxyflavone inhibits the reaction [Diethylnitrosamine results in increased expression of CTNNB1 mRNA] CTD PMID:21554863 NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
decreases activity
ISO 5,7-dimethoxyflavone inhibits the reaction [Benzo(a)pyrene results in increased expression of and results in increased activity of CYP1A1 protein]; 5,7-dimethoxyflavone inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; 5,7-dimethoxyflavone inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]
5,7-dimethoxyflavone results in decreased activity of CYP1A1 protein
CTD PMID:15661813, PMID:15905203, PMID:16484233 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 multiple interactions
decreases activity
ISO 5,7-dimethoxyflavone inhibits the reaction [Benzo(a)pyrene results in increased activity of CYP1B1 protein]; 5,7-dimethoxyflavone inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1B1 mRNA]; 5,7-dimethoxyflavone inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1B1 protein]
5,7-dimethoxyflavone results in decreased activity of CYP1B1 protein
CTD PMID:15905203, PMID:16484233, PMID:16530937 NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions EXP 5,7-dimethoxyflavone promotes the reaction [Diethylnitrosamine results in increased phosphorylation of GSK3B protein] CTD PMID:21554863 NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO 5,7-dimethoxyflavone inhibits the reaction [IL1B protein results in increased secretion of CCL2 protein]; 5,7-dimethoxyflavone inhibits the reaction [IL1B protein results in increased secretion of CXCL8 protein]; 5,7-dimethoxyflavone inhibits the reaction [IL1B protein results in increased secretion of IL6 protein] CTD PMID:24134915 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 multiple interactions ISO 5,7-dimethoxyflavone inhibits the reaction [IL1B protein results in increased secretion of IL6 protein] CTD PMID:24134915 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP 5,7-dimethoxyflavone inhibits the reaction [Diethylnitrosamine results in increased expression of NOS2 protein] CTD PMID:21554863 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP 5,7-dimethoxyflavone inhibits the reaction [Diethylnitrosamine results in increased expression of PTGS2 mRNA]; 5,7-dimethoxyflavone inhibits the reaction [Diethylnitrosamine results in increased expression of PTGS2 protein] CTD PMID:21554863 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP 5,7-dimethoxyflavone inhibits the reaction [Diethylnitrosamine results in increased expression of RELA mRNA]; 5,7-dimethoxyflavone inhibits the reaction [Diethylnitrosamine results in increased expression of RELA protein modified form] CTD PMID:21554863 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Tp53 tumor protein p53 multiple interactions EXP [5,7-dimethoxyflavone co-treated with Diethylnitrosamine] results in increased expression of TP53 mRNA; [5,7-dimethoxyflavone co-treated with Diethylnitrosamine] results in increased expression of TP53 protein CTD PMID:21554863 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Wnt3a Wnt family member 3A multiple interactions EXP 5,7-dimethoxyflavone inhibits the reaction [Diethylnitrosamine results in increased expression of WNT3A protein] CTD PMID:21554863 NCBI chr10:45,598,898...45,643,151
Ensembl chr10:45,598,912...45,638,035
JBrowse link
cirsiliol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases activity
increases metabolic processing
increases expression
ISO cirsiliol results in decreased activity of CYP1A1 protein
CYP1A1 protein results in increased metabolism of cirsiliol
cirsiliol results in increased expression of CYP1A1 mRNA
CTD PMID:19601638, PMID:21482471 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 increases expression
decreases activity
increases metabolic processing
ISO cirsiliol results in increased expression of CYP1B1 mRNA
cirsiliol results in decreased activity of CYP1B1 protein
CYP1B1 protein results in increased metabolism of cirsiliol
CTD PMID:19601638, PMID:21482471 NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722
JBrowse link
jaceosidin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO jaceosidin results in increased expression of and results in increased activity of BAX protein CTD PMID:27729209 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Casp3 caspase 3 increases activity ISO jaceosidin results in increased activity of CASP3 protein CTD PMID:27729209 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Cflar CASP8 and FADD-like apoptosis regulator decreases expression
multiple interactions
ISO jaceosidin results in decreased expression of CFLAR mRNA; jaceosidin results in decreased expression of CFLAR protein
CFLAR protein inhibits the reaction [jaceosidin results in increased cleavage of PARP1 protein]; RELA protein inhibits the reaction [jaceosidin results in decreased expression of CFLAR protein]; SP1 protein inhibits the reaction [jaceosidin results in decreased expression of CFLAR protein]
CTD PMID:27729209 NCBI chr 9:65,534,608...65,586,395
Ensembl chr 9:65,534,704...65,587,251
JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member decreases expression
multiple interactions
ISO jaceosidin results in decreased expression of MCL1 mRNA; jaceosidin results in decreased expression of MCL1 protein
MCL1 protein inhibits the reaction [jaceosidin results in increased cleavage of PARP1 protein]; RELA protein inhibits the reaction [jaceosidin results in decreased expression of MCL1 protein]; SP1 protein inhibits the reaction [jaceosidin results in decreased expression of MCL1 protein]
CTD PMID:27729209 NCBI chr 2:197,786,212...197,788,992 JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage
multiple interactions
ISO jaceosidin results in increased cleavage of PARP1 protein
benzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [jaceosidin results in increased cleavage of PARP1 protein]; CFLAR protein inhibits the reaction [jaceosidin results in increased cleavage of PARP1 protein]; MCL1 protein inhibits the reaction [jaceosidin results in increased cleavage of PARP1 protein]
CTD PMID:27729209 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO RELA protein inhibits the reaction [jaceosidin results in decreased expression of CFLAR protein]; RELA protein inhibits the reaction [jaceosidin results in decreased expression of MCL1 protein] CTD PMID:27729209 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Sp1 Sp1 transcription factor multiple interactions ISO SP1 protein inhibits the reaction [jaceosidin results in decreased expression of CFLAR protein]; SP1 protein inhibits the reaction [jaceosidin results in decreased expression of MCL1 protein] CTD PMID:27729209 NCBI chr 7:144,014,173...144,044,635
Ensembl chr 7:144,014,173...144,044,629
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19816
    chemical entity 19816
      atom 19814
        nonmetal atom 19690
          oxygen atom 19361
            oxygen molecular entity 19361
              organooxygen compound 18816
                ether 16076
                  methoxyflavone 416
                    dimethoxyflavone 28
                      3',4',5,6-tetrahydroxy-3,7-dimethoxyflavone 0
                      3',4',5-trihydroxy-3,7-dimethoxyflavone 6
                      3',5'-di-O-methyltricetin + 1
                      3',5'-dimethoxyflavone + 1
                      3,3'-dimethylquercetin 0
                      3,4'-dimethylkaempferol 0
                      4',6-dihydroxy-5,7-dimethoxyflavone 0
                      4'-O-beta-glucosyl-7-O-(6-O-sinapoylglucosyl)tricin 0
                      5,3'-di-O-methylluteolin 0
                      5,7,3',5'-tetrahydroxy-3,4'-dimethyoxyflavone 0
                      5,7,3'-trihydroxy-3,5'-dimethoxy-2'-(3'-methylbut-2-enyl)flavone 0
                      7,3',4'-trihydroxy-3,8-dimethoxyflavone 0
                      7,4'-dimethylkaempferol 0
                      apigenin 7,4'-dimethyl ether 0
                      axillarin 0
                      chrysin 5,7-dimethyl ether 17
                      cirsiliol 2
                      cirsimaritin 0
                      eupatolitin 0
                      isoorientin 7,3'-dimethyl ether 0
                      jaceosidin 7
                      ombuin 0
                      pectolinarigenin + 0
                      pectolinarin 0
                      quercetin 3,4'-dimethyl ether 0
                      rhamnacene + 0
                      syringetin 0
                      syringetin 3-glucoside 0
                      tricin 4'-O-(erythro-beta-guaiacylglyceryl) ether 7''-O-beta-D-glucopyranoside 0
                      tricin 4'-O-(erythro-beta-guaiacylglyceryl) ether 7-O-beta-D-glucopyranoside 0
                      tricin 4'-O-(erythro-beta-guaiacylglyceryl) ether 9''-O-beta-D-glucopyranoside 0
                      tricin 4'-O-(threo-beta-guaiacylglyceryl) ether 7-O-beta-D-glucopyranoside 0
                      tricin 5-O-beta-D-glucoside 0
                      tricin 7-O-(6''-O-malonyl)-beta-D-glucopyranoside 0
                      tricin 7-O-[sinapoyl]-glucoside 0
                      tricin 7-O-beta-D-glucoside 0
                      tricin 7-O-glucoside + 0
                      tricin 7-O-neohesperidoside 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19816
    subatomic particle 19814
      composite particle 19814
        hadron 19814
          baryon 19814
            nucleon 19814
              atomic nucleus 19814
                atom 19814
                  main group element atom 19702
                    p-block element atom 19702
                      carbon group element atom 19608
                        carbon atom 19597
                          organic molecular entity 19597
                            organic molecule 19522
                              organic cyclic compound 19320
                                organic heterocyclic compound 18432
                                  oxacycle 17200
                                    benzopyran 10142
                                      1-benzopyran 9858
                                        flavonoid 6376
                                          flavones 4169
                                            methoxyflavone 416
                                              dimethoxyflavone 28
                                                3',4',5,6-tetrahydroxy-3,7-dimethoxyflavone 0
                                                3',4',5-trihydroxy-3,7-dimethoxyflavone 6
                                                3',5'-di-O-methyltricetin + 1
                                                3',5'-dimethoxyflavone + 1
                                                3,3'-dimethylquercetin 0
                                                3,4'-dimethylkaempferol 0
                                                4',6-dihydroxy-5,7-dimethoxyflavone 0
                                                4'-O-beta-glucosyl-7-O-(6-O-sinapoylglucosyl)tricin 0
                                                5,3'-di-O-methylluteolin 0
                                                5,7,3',5'-tetrahydroxy-3,4'-dimethyoxyflavone 0
                                                5,7,3'-trihydroxy-3,5'-dimethoxy-2'-(3'-methylbut-2-enyl)flavone 0
                                                7,3',4'-trihydroxy-3,8-dimethoxyflavone 0
                                                7,4'-dimethylkaempferol 0
                                                apigenin 7,4'-dimethyl ether 0
                                                axillarin 0
                                                chrysin 5,7-dimethyl ether 17
                                                cirsiliol 2
                                                cirsimaritin 0
                                                eupatolitin 0
                                                isoorientin 7,3'-dimethyl ether 0
                                                jaceosidin 7
                                                ombuin 0
                                                pectolinarigenin + 0
                                                pectolinarin 0
                                                quercetin 3,4'-dimethyl ether 0
                                                rhamnacene + 0
                                                syringetin 0
                                                syringetin 3-glucoside 0
                                                tricin 4'-O-(erythro-beta-guaiacylglyceryl) ether 7''-O-beta-D-glucopyranoside 0
                                                tricin 4'-O-(erythro-beta-guaiacylglyceryl) ether 7-O-beta-D-glucopyranoside 0
                                                tricin 4'-O-(erythro-beta-guaiacylglyceryl) ether 9''-O-beta-D-glucopyranoside 0
                                                tricin 4'-O-(threo-beta-guaiacylglyceryl) ether 7-O-beta-D-glucopyranoside 0
                                                tricin 5-O-beta-D-glucoside 0
                                                tricin 7-O-(6''-O-malonyl)-beta-D-glucopyranoside 0
                                                tricin 7-O-[sinapoyl]-glucoside 0
                                                tricin 7-O-beta-D-glucoside 0
                                                tricin 7-O-glucoside + 0
                                                tricin 7-O-neohesperidoside 0
paths to the root

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.