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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:acarbose
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Accession:CHEBI:2376 term browser browse the term
Definition:A tetrasaccharide derivative consisting of a dideoxy-4-{[4,5,6-trihydroxy-3-(hydroxymethyl)cyclohex-2-en-1-yl C7 cyclitol moiety [called valienol (or valienamine)] linked via nitrogen to isomaltotriose.
Synonyms:exact_synonym: 4,6-dideoxy-4-{[(1S,4R,5S,6S)-4,5,6-trihydroxy-3-(hydroxymethyl)cyclohex-2-en-1-yl]amino}-alpha-D-glucopyranosyl-(1->4)-alpha-D-glucopyranosyl-(1->4)-D-glucopyranose
 related_synonym: Formula=C25H43NO18;   Glucobay;   InChI=1S/C25H43NO18/c1-6-11(26-8-2-7(3-27)12(30)15(33)13(8)31)14(32)19(37)24(40-6)43-22-10(5-29)42-25(20(38)17(22)35)44-21-9(4-28)41-23(39)18(36)16(21)34/h2,6,8-39H,3-5H2,1H3/t6-,8+,9-,10-,11-,12+,13+,14+,15+,16-,17-,18-,19-,20-,21-,22-,23-,24-,25-/m1/s1;   InChIKey=XUFXOAAUWZOOIT-UGEKTDRHSA-N;   Precose;   SMILES=C[C@H]1O[C@H](O[C@@H]2[C@@H](CO)O[C@H](O[C@@H]3[C@@H](CO)OC(O)[C@H](O)[C@H]3O)[C@H](O)[C@H]2O)[C@H](O)[C@@H](O)[C@@H]1N[C@H]1C=C(CO)[C@@H](O)[C@H](O)[C@H]1O;   acarbosa;   acarbosum
 alt_id: CHEBI:40513
 xref: CAS:56180-94-0;   Chemspider:38116;   DrugBank:DB00284;   Drug_Central:39;   HMDB:HMDB0014429;   KEGG:C06802;   KEGG:D00216;   KNApSAcK:C00016021;   LINCS:LSM-4345
 xref_mesh: MESH:D020909
 xref: PMID:11937512;   PMID:18248270;   PMID:24245565;   PMID:25044702;   PMID:8893066;   PMID:9805641;   Patent:DE2347782;   Patent:US4062950;   Wikipedia:Acarbose
 cyclic_relationship: is_conjugate_base_of CHEBI:84363



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acarbose term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace2 angiotensin I converting enzyme 2 decreases expression ISO Acarbose results in decreased expression of ACE2 mRNA CTD PMID:32808185 NCBI chr  X:30,293,597...30,340,961
Ensembl chr  X:30,293,589...30,340,977
JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing increases expression EXP Acarbose results in increased expression of ADIPOQ protein CTD PMID:18290871 NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions EXP Acarbose inhibits the reaction [Fructose results in increased expression of CCL2 mRNA]; Acarbose inhibits the reaction [Fructose results in increased expression of CCL2 protein] CTD PMID:17133782 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 decreases expression EXP Acarbose results in decreased expression of CYP2E1 mRNA CTD PMID:14975757 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
JBrowse link
G Fasn fatty acid synthase decreases expression EXP Acarbose results in decreased expression of FASN mRNA; Acarbose results in decreased expression of FASN protein CTD PMID:8101498 NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261
JBrowse link
G Lep leptin decreases expression EXP Acarbose results in decreased expression of LEP protein CTD PMID:18290871 NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262
JBrowse link
G Mgam maltase-glucoamylase decreases activity ISO Acarbose results in decreased activity of MGAM protein CTD PMID:17585022 PMID:20349118 NCBI chr 4:69,624,024...69,715,782
Ensembl chr 4:69,637,799...69,683,742
JBrowse link
G Npy neuropeptide Y decreases expression EXP Acarbose results in decreased expression of NPY protein CTD PMID:18290871 NCBI chr 4:78,881,294...78,888,495
Ensembl chr 4:78,881,264...78,888,495
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha affects response to substance ISO PPARGC1A protein polymorphism affects the susceptibility to Acarbose CTD PMID:15592662 NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656
JBrowse link
G Slc2a1 solute carrier family 2 member 1 increases expression EXP Acarbose results in increased expression of SLC2A1 protein CTD PMID:11779583 NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416
JBrowse link
G Slc2a4 solute carrier family 2 member 4 increases expression EXP Acarbose results in increased expression of SLC2A4 mRNA; Acarbose results in increased expression of SLC2A4 protein CTD PMID:1767839 NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565
JBrowse link
G Sqstm1 sequestosome 1 affects response to substance ISO SQSTM1 affects the susceptibility to Acarbose CTD PMID:19207582 NCBI chr10:34,525,517...34,536,685
Ensembl chr10:34,525,519...34,536,673
JBrowse link
G Tnf tumor necrosis factor decreases expression
multiple interactions
ISO
EXP
Acarbose results in decreased expression of TNF mRNA
Acarbose results in decreased expression of TNF mRNA; Acarbose results in decreased expression of TNF protein
Acarbose inhibits the reaction [Oxygen deficiency results in increased expression of TNF mRNA]
CTD PMID:12717270 PMID:14975757 PMID:20703014 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link

Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 20050
    role 20001
      application 19737
        pharmaceutical 19610
          drug 19610
            hypoglycemic agent 4147
              acarbose 13
                acarbose 7(IV)-phosphate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 20050
    subatomic particle 20048
      composite particle 20048
        hadron 20048
          baryon 20048
            nucleon 20048
              atomic nucleus 20048
                atom 20048
                  main group element atom 19948
                    p-block element atom 19948
                      carbon group element atom 19872
                        carbon atom 19863
                          organic molecular entity 19863
                            heteroorganic entity 19544
                              organochalcogen compound 19283
                                organooxygen compound 19228
                                  carbohydrates and carbohydrate derivatives 13915
                                    carbohydrate 13915
                                      oligosaccharide 578
                                        tetrasaccharide 16
                                          tetrasaccharide derivative 14
                                            acarbose 13
                                              acarbose 7(IV)-phosphate 0
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