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G |
Adcyap1 |
adenylate cyclase activating polypeptide 1 |
decreases expression |
EXP |
diepoxybutane results in decreased expression of ADCYAP1 mRNA |
CTD |
PMID:12242682 |
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NCBI chr 9:121,705,897...121,725,736
Ensembl chr 9:121,706,979...121,725,716
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G |
Apaf1 |
apoptotic peptidase activating factor 1 |
increases expression |
ISO |
diepoxybutane results in increased expression of APAF1 mRNA |
CTD |
PMID:29792945 |
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NCBI chr 7:31,699,309...31,784,192
Ensembl chr 7:31,699,885...31,784,192
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G |
Atm |
ATM serine/threonine kinase |
multiple interactions increases phosphorylation increases response to substance |
ISO |
ATM protein affects the reaction [diepoxybutane results in increased phosphorylation of TP53 protein] diepoxybutane results in increased phosphorylation of ATM protein ATM protein results in increased susceptibility to diepoxybutane |
CTD |
PMID:20024960 PMID:25633853 |
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NCBI chr 8:58,015,938...58,119,973
Ensembl chr 8:58,015,940...58,120,045
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G |
Bak1 |
BCL2-antagonist/killer 1 |
increases expression |
ISO |
diepoxybutane results in increased expression of BAK1; diepoxybutane results in increased expression of BAK1 mRNA |
CTD |
PMID:17693053 PMID:29792945 |
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NCBI chr20:5,609,620...5,618,899
Ensembl chr20:5,609,625...5,618,260
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G |
Bax |
BCL2 associated X, apoptosis regulator |
increases expression |
ISO |
diepoxybutane results in increased expression of BAX; diepoxybutane results in increased expression of BAX mRNA |
CTD |
PMID:17693053 PMID:29792945 |
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NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
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G |
Bbc3 |
Bcl-2 binding component 3 |
increases expression |
ISO |
diepoxybutane results in increased expression of BBC3 mRNA |
CTD |
PMID:29792945 |
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NCBI chr 1:78,261,491...78,267,802
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Bcl2 |
BCL2, apoptosis regulator |
increases expression |
ISO |
diepoxybutane results in increased expression of BCL2 mRNA |
CTD |
PMID:29792945 |
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NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
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G |
Bcl2l11 |
BCL2 like 11 |
increases expression |
ISO |
diepoxybutane results in increased expression of BCL2L11 mRNA |
CTD |
PMID:29792945 |
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NCBI chr 3:120,726,906...120,764,192
Ensembl chr 3:120,726,906...120,764,192
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G |
Bok |
BCL2 family apoptosis regulator BOK |
increases expression |
ISO |
diepoxybutane results in increased expression of BOK mRNA |
CTD |
PMID:29792945 |
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NCBI chr 9:100,829,593...100,840,498
Ensembl chr 9:100,829,552...100,840,504
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G |
Casp2 |
caspase 2 |
increases expression |
ISO |
diepoxybutane results in increased expression of CASP2 mRNA |
CTD |
PMID:29792945 |
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NCBI chr 4:71,652,358...71,670,228
Ensembl chr 4:71,652,354...71,670,239
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G |
Casp3 |
caspase 3 |
increases activity multiple interactions |
ISO |
diepoxybutane results in increased activity of CASP3 protein benzoylcarbonyl-aspartyl-glutamyl-valyl-aspartyl-fluoromethyl ketone inhibits the reaction [diepoxybutane results in increased activity of CASP3 protein] |
CTD |
PMID:14998682 |
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NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
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G |
Casp8 |
caspase 8 |
increases expression |
ISO |
diepoxybutane results in increased expression of CASP8 mRNA |
CTD |
PMID:29792945 |
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NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
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G |
Casp9 |
caspase 9 |
multiple interactions increases expression increases activity |
ISO |
benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone inhibits the reaction [diepoxybutane results in increased activity of CASP9 protein] diepoxybutane results in increased expression of CASP9 mRNA |
CTD |
PMID:14998682 PMID:29792945 |
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NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
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G |
Ccnb1 |
cyclin B1 |
multiple interactions increases expression |
ISO |
Acetylcysteine inhibits the reaction [diepoxybutane results in increased expression of CCNB1 protein] |
CTD |
PMID:25633853 |
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NCBI chr 2:30,782,133...30,791,106
Ensembl chr 2:30,783,915...30,791,221
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G |
Cdc25c |
cell division cycle 25C |
multiple interactions increases phosphorylation increases expression |
ISO |
7-hydroxystaurosporine inhibits the reaction [diepoxybutane results in increased expression of CDC25C protein modified form]; Acetylcysteine inhibits the reaction [diepoxybutane results in increased expression of CDC25C protein modified form]; CHEK1 protein promotes the reaction [diepoxybutane results in increased expression of CDC25C protein modified form] diepoxybutane results in increased phosphorylation of CDC25C protein |
CTD |
PMID:25633853 |
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NCBI chr18:27,528,768...27,550,316
Ensembl chr18:27,528,354...27,550,224
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G |
Cdk1 |
cyclin-dependent kinase 1 |
multiple interactions increases expression |
ISO |
7-hydroxystaurosporine inhibits the reaction [diepoxybutane results in increased expression of CDK1 protein modified form]; Acetylcysteine inhibits the reaction [diepoxybutane results in increased expression of CDK1 protein]; CHEK1 protein promotes the reaction [diepoxybutane results in increased expression of CDK1 protein modified form] diepoxybutane results in increased expression of CDK1 protein; diepoxybutane results in increased expression of CDK1 protein modified form |
CTD |
PMID:25633853 |
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NCBI chr20:20,576,341...20,591,510
Ensembl chr20:20,576,377...20,591,549
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G |
Chek1 |
checkpoint kinase 1 |
multiple interactions increases expression increases phosphorylation |
ISO |
7-hydroxystaurosporine inhibits the reaction [diepoxybutane results in increased expression of CHEK1 protein modified form]; Acetylcysteine inhibits the reaction [diepoxybutane results in increased expression of CHEK1 protein modified form]; CHEK1 protein promotes the reaction [diepoxybutane results in increased expression of CDC25C protein modified form]; CHEK1 protein promotes the reaction [diepoxybutane results in increased expression of CDK1 protein modified form] diepoxybutane results in increased phosphorylation of CHEK1 protein |
CTD |
PMID:25633853 |
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NCBI chr 8:39,181,162...39,201,588
Ensembl chr 8:39,181,163...39,243,882
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G |
Cyp2e1 |
cytochrome P450, family 2, subfamily e, polypeptide 1 |
affects response to substance increases response to substance |
ISO |
CYP2E1 gene polymorphism affects the susceptibility to diepoxybutane CYP2E1 gene polymorphism results in increased susceptibility to diepoxybutane |
CTD |
PMID:15036125 PMID:17078101 |
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NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
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G |
Diablo |
diablo, IAP-binding mitochondrial protein |
increases expression |
ISO |
diepoxybutane results in increased expression of DIABLO mRNA |
CTD |
PMID:29792945 |
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NCBI chr12:38,490,230...38,503,344
Ensembl chr12:38,490,230...38,503,330
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G |
Ephx1 |
epoxide hydrolase 1 |
affects response to substance increases response to substance |
ISO |
EPHX1 gene polymorphism affects the susceptibility to diepoxybutane EPHX1 gene mutant form results in increased susceptibility to diepoxybutane |
CTD |
PMID:12929123 PMID:15036125 |
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NCBI chr13:99,271,390...99,300,580
Ensembl chr13:99,271,366...99,300,579
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G |
Fancd2 |
FA complementation group D2 |
multiple interactions |
ISO |
[Arsenic Trioxide results in decreased activity of FANCD2 protein] which results in increased susceptibility to diepoxybutane; [monomethylarsonic acid results in decreased activity of FANCD2 protein] which results in increased susceptibility to diepoxybutane |
CTD |
PMID:25092648 |
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NCBI chr 4:145,489,869...145,551,479
Ensembl chr 4:145,489,869...145,551,479
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G |
Gstt1 |
glutathione S-transferase theta 1 |
affects response to substance multiple interactions decreases activity increases response to substance |
ISO EXP |
GSTT1 gene polymorphism affects the susceptibility to diepoxybutane GSTT1 protein affects the metabolism of and results in increased activity of diepoxybutane GSTT1 protein results in decreased activity of diepoxybutane GSTT1 gene polymorphism results in increased susceptibility to diepoxybutane |
CTD |
PMID:7578934 PMID:8565128 PMID:12694746 PMID:15036125 PMID:17078101 |
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NCBI chr20:13,799,102...13,816,527
Ensembl chr20:13,799,102...13,816,526
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G |
H2ax |
H2A.X variant histone |
multiple interactions increases expression |
ISO |
Acetylcysteine inhibits the reaction [diepoxybutane results in increased expression of H2AX protein modified form] |
CTD |
PMID:25633853 |
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NCBI chr 8:48,665,652...48,666,981
Ensembl chr 8:48,665,652...48,666,981
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G |
Hprt1 |
hypoxanthine phosphoribosyltransferase 1 |
increases mutagenesis |
ISO |
diepoxybutane results in increased mutagenesis of HPRT1 gene |
CTD |
PMID:20853577 |
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NCBI chr X:158,196,640...158,228,815
Ensembl chr X:158,197,149...158,228,749 Ensembl chr X:158,197,149...158,228,749
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G |
Mdm2 |
MDM2 proto-oncogene |
multiple interactions |
ISO |
diepoxybutane inhibits the reaction [TP53 protein binds to MDM2 protein] |
CTD |
PMID:20024960 |
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NCBI chr 7:60,719,060...60,743,618
Ensembl chr 7:60,719,066...60,743,328
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G |
Mmp9 |
matrix metallopeptidase 9 |
decreases activity |
EXP |
diepoxybutane results in decreased activity of MMP9 protein |
CTD |
PMID:12242682 |
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NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
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G |
Nat2 |
N-acetyltransferase 2 |
decreases response to substance |
ISO |
NAT2 gene polymorphism results in decreased susceptibility to diepoxybutane |
CTD |
PMID:17078101 |
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NCBI chr16:23,960,709...23,991,570
Ensembl chr16:23,961,067...23,991,570
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G |
Parp1 |
poly (ADP-ribose) polymerase 1 |
increases cleavage |
ISO |
diepoxybutane results in increased cleavage of PARP1 protein |
CTD |
PMID:14998682 |
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NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
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G |
Polb |
DNA polymerase beta |
multiple interactions |
ISO |
[diepoxybutane binds to 2'-deoxyadenosine] which results in decreased activity of POLB protein |
CTD |
PMID:26098310 |
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NCBI chr16:74,237,001...74,260,272
Ensembl chr16:74,237,001...74,260,271
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G |
Poli |
DNA polymerase iota |
multiple interactions |
ISO |
[diepoxybutane binds to 2'-deoxyadenosine] which results in decreased activity of POLI protein; POLN protein inhibits the reaction [[diepoxybutane binds to 2'-deoxyadenosine] which results in decreased activity of POLI protein] |
CTD |
PMID:26098310 |
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NCBI chr18:65,749,107...65,768,805
Ensembl chr18:65,748,908...65,768,781
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G |
Polk |
DNA polymerase kappa |
multiple interactions |
ISO |
[diepoxybutane binds to 2'-deoxyadenosine] which results in decreased activity of POLK protein |
CTD |
PMID:26098310 |
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NCBI chr 2:27,305,718...27,364,906
Ensembl chr 2:27,305,728...27,364,906
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G |
Poln |
DNA polymerase nu |
multiple interactions |
ISO |
[diepoxybutane binds to 2'-deoxyadenosine] which results in decreased activity of POLN protein; POLN protein inhibits the reaction [[diepoxybutane binds to 2'-deoxyadenosine] which results in decreased activity of POLI protein] |
CTD |
PMID:26098310 |
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NCBI chr14:81,837,764...82,037,999
Ensembl chr14:81,858,737...82,037,747
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G |
Tank |
TRAF family member-associated NFKB activator |
increases expression |
ISO |
diepoxybutane results in increased expression of TANK mRNA |
CTD |
PMID:29792945 |
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NCBI chr 3:47,439,007...47,515,706
Ensembl chr 3:47,439,076...47,515,700
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G |
Tp53 |
tumor protein p53 |
increases expression multiple interactions |
ISO |
diepoxybutane results in increased expression of TP53 protein ATM protein affects the reaction [diepoxybutane results in increased phosphorylation of TP53 protein]; diepoxybutane inhibits the reaction [TP53 protein binds to MDM2 protein]; diepoxybutane results in increased acetylation of and results in increased phosphorylation of TP53 protein; diepoxybutane results in increased expression of and results in increased stability of TP53 protein; TP53 protein affects the reaction [diepoxybutane results in increased expression of XCL1 mRNA] |
CTD |
PMID:14998682 PMID:20024960 PMID:31953984 |
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NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
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G |
Xcl1 |
X-C motif chemokine ligand 1 |
multiple interactions increases expression |
ISO |
TP53 protein affects the reaction [diepoxybutane results in increased expression of XCL1 mRNA] |
CTD |
PMID:31953984 |
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NCBI chr13:83,199,402...83,202,845
Ensembl chr13:83,199,264...83,202,864
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